Global initiative for asthma classification of asthma control derived from theasthma control questionnaire dataJC Virchow 1 , A Bufe 2 , D Seitzberg 3 , ED Bateman 41Department of Pneumology, University of Rostock, Rostock, Germany; 2 Experimental Pneumology, Ruhr University Bochum, Bochum, Germany; 3 Research &Development, <strong>ALK</strong>, Hørsholm, Denmark; 4 Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South AfricaHouse Dust Mite AITBackgroundThe asthma control questionnaire (ACQ) is a useful scientifictool for assessing levels of asthma control in clinical trialsettings. However, clinicians may be unfamiliar with the ACQscores. Therefore, we aimed to translate ACQ scores intothe global initiative for asthma (GINA) treatment guidelineterminology for asthma control, i.e. “controlled”, “partlycontrolled” or “uncontrolled” to make them more easilyinterpretable. This may be useful for both understandingclinical trial data and for interpreting it for clinical use. Datafrom a large, randomised, double-blind, placebo-controlledtrial with 3 doses of the house dust mite (HDM) allergyimmunotherapy tablet (AIT) (<strong>ALK</strong>, Denmark) was used.MethodThe trial population comprised 604 subjects, aged 14years or older with evidence of HDM induced mild tomoderate persistent asthma according to the GINA 2006guideline and with daily use of low-medium dose inhaledcorticosteroid (ICS). Prior to randomisation, the use of ICSwas standardised and tapered to the lowest dose providingadequate asthma control. ACQ scores were obtained atrandomisation. Post hoc an algorithm was constructed totranslate the 7 ACQ questions into GINA terminology.ResultAt randomisation, 21% (N=127) of the trial population hadcontrolled asthma according to GINA terminology, with amean ACQ score of 0.24 [CI: 0.20-0.28] and mean FEV1 of96% of predicted value. Another 69% (N=412) had partlycontrolled asthma, with a mean ACQ score of 0.86 [CI: 0.82-0.90] and a mean FEV1 of 94%. Finally, 10% (N=60) haduncontrolled asthma, with a mean ACQ score of 1.54[CI: 1.41-1.66] and a mean FEV1 of 90%. In the trialpopulation overall, the HDM AIT was well tolerated andefficacious in terms of ICS reduction.ConclusionFrom the ACQ, it is possible to classify the patients’levels of asthma control into the GINA 2009 definitionsof “controlled”, “partly controlled” or “uncontrolled”. Theselection of subjects with HDM induced mild to moderatepersistent asthma and low-medium ICS use resulted ina trial population comprising 69% of subjects with partlycontrolled asthma according to GINA terminology and10% with uncontrolled asthma. The data confirmedthat lung function in terms of FEV1 contributes little tothe asthma control classification. Our data suggest thatin patients with partly or even uncontrolled asthma,whose lung function is not severely impaired, treatmentwith HDM AIT may be well tolerated.30Abstract number: 1673. Session date and time: Tuesday 14 June, 12.00 - 13.30Session: Poster session – Patient recorded outcomes and other paraclinical aspects in immunology. Session room: Rumeli Hall
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