âThe evolution of the classification of nephrotic syndrome and the ...

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The role of the renopoietic systemHierarchical distribution of CD133+CD24+PDX- andCD133+CD24+PDX+ cells within human glomeruliRonconi, E. et al. J Am Soc Nephrol 2009;20:322-332Copyright ©2009 American Society of Nephrology
Hypothesis #2The role of CD24+CD133+ renal progenitors in FSGS & CG.Podocyte injuryAlteredphenotypePodocytedeathDevelopmentalarrestPodocytedeathNo change inpodocyte numberCD24+CD133+Repair activityProliferation(low)ExuberantCD24+CD133+ActivityNo changeSegmentalsclerosisMesangialsclerosispseudocrescentsMCNFSGSDMSCG
Page 1 and 2: “The evolution of the classificat
Page 3 and 4: Nephrotic syndrome - the 80’s and
Page 5 and 6: Limitations of the morphologicclass
Page 7 and 8: PodocytopathiesDEFINITION: Proteinu
Page 9: Podocytopathies:4 morphologic patte
Page 13: Hypothesis #1:Injured podocytes can
Page 17 and 18: Minimal Change NephropathyDEFINITIO
Page 19 and 20: Can pathologists discriminatebetwee
Page 21 and 22: DG staining in steroid sensitive an
Page 23 and 24: FOCAL SEGMENTALGLOMERULOSCLEROSIS
Page 25 and 26: Idiopathic FSGSIs idiopathic really
Page 27 and 28: Reactive forms:Hyperfiltration-medi
Page 29 and 30: FSGS: From podocyte hypertrophy to
Page 31 and 32: DMSDEFINITION:Diffuse increase of m
Page 33 and 34: NPHS3-PLCE1Chromosome 10q23.32-q24.
Page 35 and 36: CG Definition: GBM collapse andpseu
Page 37 and 38: TAXONOMY OF PODOCYTOPATHIESidiopath

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