2nd annual MGSE Symposium - Institute for Evolution and ...

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18 biograPhy Richard Goldstein Public lecture by richard goldstein 1989 PhD, Stanford Biophysics 1989- 1990 Foreign teacher, Shanghai 1990- 1993 Post doc - Peter Wolynes - U of Illinois - 1993- 2002 Asst/Assoc Professor, Chemistry and Biophysics, U of Michigan 2002-2003 Head of bioinformatics, Siena Biotech 2003-present Programme Leader, National Institute for Medical Research, London, UK
DecoDing the evolutionary recorD: What aDvanceD moDels of sequence change reveal to us about proteins Nature has been performing ultra high throughput in vivo site-directed mutagenesis studies for the past few billion years. The resulting evolutionary record contains a wealth of information about proteins, their structure, function, and physiological context, and how proteins adapt to changing circumstances. Unfortunately, standard phenomenological models used to analyse sequence change generally assume the effects we are most interested in do not exist. By constructing more mechanistic models that explicitly consider the process of mutation and selection we can decipher the resulting patterns of sequence variation and conservation, providing us access to Nature’s lab notebook. We use these models to represent the nature of the selective constraints acting on protein sequences, to examine how protein sequences in influenza adapt to changes of host, and to characterise the effect of mutations on proteins - what proportions are deleterious, neutral, advantageous - an important distribution for modelling of population genetics. Publications Liberles, et. al. (2012) The interface of protein structure, protein biophysics, and molecular evolution. Protein Science Pollock, et al. (2012) Amino acid coevolution induces an evolutionary Stokes shift. PNAS Tamuri, et al. (2012) Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutationselection models. Genetics 19
Page 1: 2 nd annual MGSE Symposium INTERDIS
Page 4 and 5: 4 Impressum 2 nd MGSE Symposium Abs
Page 7 and 8: programme 7
Page 9 and 10: 17:00 17:15 18:00 18:30 Short break
Page 13: Evolution is not only the change ac
Page 17: publIc lectures 17
Page 21: genome plasticity in ehec The bacte
Page 24 and 25: Prof. Dr. Joachim Kurtz 1 Prof. Dr.
Page 26 and 27: Alexander Christian 1 1 Institute f
Page 28 and 29: Felipe Torres 1 1 Institute for Mat
Page 30: Dr. Christoph Preuss Westfälische-
Page 33 and 34: Adaptive conflicts in protein evolu
Page 35 and 36: Transcriptomic resilience to global
Page 37 and 38: along these N gradients, we have fo
Page 40 and 41: Denise Meister 1 Harald Strauss 1 1
Page 42 and 43: Katharina Siedenberg 1 Harald Strau
Page 44: Gesellschaft für Arteriosklerosefo
Page 47 and 48: The effects of genotype and social
Page 49: Discovering the genetic background
Page 52 and 53: 52 the hIstory of the botanIcal gar
Page 54 and 55: 54 In 1913 he managed to make the g
Page 56 and 57: 56 A newly built pavilion is erecte
Page 58 and 59: 58 map & contact Botanischer Garten
Page 61 and 62: members of the mgse 61
Page 63 and 64: the mgse Junior Professor Francesco
Page 65: Schulze-Bahr, Prof. Eric Towards ev
Page 68 and 69:
68 addresses of Presenters Bohle, D
Page 71:
notes 71
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