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2nd annual MGSE Symposium - Institute for Evolution and ...

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Tobias Sikosek 1<br />

34<br />

Furthermore, bi-stable proteins may provide an additional advantage after gene<br />

duplication, because they provide excellent starting points <strong>for</strong> subfunctionalisation<br />

(functional divergence driven by adaptation <strong>and</strong>/or genotype space entropy), as<br />

consistent with the recently proposed Escape from Adaptive Conflict model. The potential<br />

<strong>for</strong> increased evolvability due to bi-stable proteins is thus two-fold by allowing adaptation<br />

be<strong>for</strong>e <strong>and</strong> after gene duplication.

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