2nd annual MGSE Symposium - Institute for Evolution and ...

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Mona Reimenschneider 1 Monika Stoll 1 Christoph Preuss 2 1 Leibniz-Institute for Arteriosclerosis Research, University of Münster 2 Institute for Evolution and Biodiversity, Westfälische Wilhelms-University, Münster mona.riemenschneider @lifa-muenster.de 46 Coordinate evolution of co-expression networks among linked gene clusters Gene order along chromosomes is not random in eukaryotic genomes. Several studies have revealed that genes sharing similar expression patterns are functionally related and tend to form linked gene cluster. Structural, regulatory and functional factors might play a role in the formation of these linked gene clusters. Only little is known regarding the mechanisms of gene cluster formation and if natural selection had an impact in maintaining favorable allele combinations. We are interested in deciphering the possible consequences of gene cluster formation in regards to complex traits, such as diseases. Therefore, we performed evolutionary analysis across multiple vertebrate genomes in order to test whether co-regulated genes are wired de novo or whether disease related genes are co-opted into different regulatory networks along vertebrate evolution. Also the impact of recent adaptation in distinct human populations and patterns of recent selection within linked gene clusters is studied.
The effects of genotype and social experience during adolescence on aggressiveness and anxiety later in life: pathology, constraint or adaptation Across mammalian species, behavioral traits like anxiety and aggressiveness are means to optimally cope with environmental challenges. However, in their exaggerated forms both traits pose serious psychiatric problems to human societies. Levels of aggressiveness and anxiety can be shaped by genotype and experiences during development and recent findings suggest that, in particular the time of adolescence can be of importance. From a biomedical point of view, high levels of anxiety and aggressiveness are regarded as ‘pathological’ (nonadaptive) consequences or constraints of adverse conditions. But from an evolutionary perspective these traits might be adaptive to the present environment and would be an effective epigenetic mechanism for repeated and rapid adaptations [1]. To elucidate (1) how levels of anxiety and aggressiveness are shaped by genotype and experience during adolescence and (2) whether the resulting traits adjust the individuals to the current environmental conditions, experiments are conducted with serotonintransporter (5-HTT) knockout mice, a well established model for the study of anxiety and aggression [2]. Male wildtype, heterozygous, and homozygous 5-HTT knockout mice, which are known to differ in inborn levels of anxiety and aggressiveness, are compared. During adolescence males of all three genotypes either experience an excellent social situation in which important resources are freely available (e.g., access to mating partner) or they will find themselves in an adverse situation (e.g., chronic subordination). In adulthood, aggressiveness and anxiety-related behaviour is assessed in a battery of tests. In addition, it will be studied whether individual differences in behavioural profiles are related to epigenetic modification of gene promoters in the central nervous system. Finally, match-mismatch experiments [3] will be conducted to find out whether males indeed cope better and have higher reproductive success under conditions comparable to those they have experienced during adolescence. Neele Meyer 1 1 Institute for Evolution and Biodiversity, Westfälische Wilhelms-University, Münster [1) Sachser et al. 2011 Neurosci. Biobehav. Rev. 35:1518–1533 [2] Canli and Lesch 2007 Nature Neurosci 10:1103-1109 [3] Bateson et al. 2004 Nature 430:419-421 neele.meyer1@gmail. com 47
Page 1: 2 nd annual MGSE Symposium INTERDIS
Page 4 and 5: 4 Impressum 2 nd MGSE Symposium Abs
Page 7 and 8: programme 7
Page 9 and 10: 17:00 17:15 18:00 18:30 Short break
Page 13: Evolution is not only the change ac
Page 17 and 18: publIc lectures 17
Page 19 and 20: DecoDing the evolutionary recorD: W
Page 21: genome plasticity in ehec The bacte
Page 24 and 25: Prof. Dr. Joachim Kurtz 1 Prof. Dr.
Page 26 and 27: Alexander Christian 1 1 Institute f
Page 28 and 29: Felipe Torres 1 1 Institute for Mat
Page 30: Dr. Christoph Preuss Westfälische-
Page 33 and 34: Adaptive conflicts in protein evolu
Page 35 and 36: Transcriptomic resilience to global
Page 37 and 38: along these N gradients, we have fo
Page 40 and 41: Denise Meister 1 Harald Strauss 1 1
Page 42 and 43: Katharina Siedenberg 1 Harald Strau
Page 44: Gesellschaft für Arteriosklerosefo
Page 49: Discovering the genetic background
Page 52 and 53: 52 the hIstory of the botanIcal gar
Page 54 and 55: 54 In 1913 he managed to make the g
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Page 58 and 59: 58 map & contact Botanischer Garten
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Page 63 and 64: the mgse Junior Professor Francesco
Page 65: Schulze-Bahr, Prof. Eric Towards ev
Page 68 and 69: 68 addresses of Presenters Bohle, D
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