2nd annual MGSE Symposium - Institute for Evolution and ...

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20 biograPhy Helge Karch Public lecture by helge Karch 1979 Dipl. Biol., University of Darmstadt 1982 PhD, University of Darmstadt, Prof. Dr. K. Nixdorff 1982 - 1984 Fellow, Ruhr-University Bochum 1984 - 1989 Fellow, University of Hamburg 1989 Habilitation in Medical Microbiology, University of Hamburg 1990 - 2001 Professor at the Institute for Hygiene and Microbiology, Bayrische Julius-Maximilians-University Würzburg 2001 - present Professor and Director of the Institute for Hygiene, Westfälische Wilhelms-University Münster
genome plasticity in ehec The bacterial genome size and organization is considerably variable. Bacterial chromosomes are not fixed molecules, either in evolution over long periods, or even in microevolution during human infection. Throughout infection, strong selective pressures are exerted on EHEC. The resulting genetic changes of these pathogens might influence clinical outcome and have impact on diagnosis and epidemiology. EHEC are an excellent example of this process. These bacteria cause diarrhea, bloody diarrhea, and hemolytic uremic syndrome (HUS) in humans, whereas in their natural habitat they are mostly asymptomatic colonizers of animals. Thus, EHEC have to react quickly in their ability to change from one milieu to another, and the greatest challenge might ensue when infecting humans. Transferable genetic elements such as bacteriophages and plasmids can function as vehicles laterally transporting genetic information, thus playing an important role in EHEC evolution. All EHEC possess Shiga toxin-converting bacteriophages, which can genetically modify its host after insertion into the chromosome rendering strains highly pathogenic. We have demonstrated that profound chromosomal changes occur during the brief period that EHEC pass through the human gut leading to gain and loss of virulence determinants. The role of transferable elements as vectors as well as the constantly ongoing recombination between different mobilizable and transferable DNA elements is exemplified by the description of the association of a multidrug resistance plasmid and by a large virulence plasmid in the 2011 outbreak strain O104:H4. This pathogen caused the largest outbreak of HUS in recorded history which centered in northern Germany in May and June 2011. The intensive study of human enteric factors that induce or modulate pathogen chromosome instability could open new vistas into host-microbial interactions. Publications Bielaszewska M. et al., ( 2012), Effects of Antibiotics on Shiga Toxin 2 Production and Bacteriophage Induction by Epidemic Escherichia coli O104:H4 Strain, AAC Zhang W. et al. (2012), Real-time multiplex PCR for detecting Shiga toxin 2-producing Escherichia coli O104:H4 in human stools., JCM Müthing J. et al. (2012), Promiscuous Shiga toxin 2e and its intimate relationship to Forssman, Glycobiology 21
Page 1: 2 nd annual MGSE Symposium INTERDIS
Page 4 and 5: 4 Impressum 2 nd MGSE Symposium Abs
Page 7 and 8: programme 7
Page 9 and 10: 17:00 17:15 18:00 18:30 Short break
Page 13: Evolution is not only the change ac
Page 17 and 18: publIc lectures 17
Page 19: DecoDing the evolutionary recorD: W
Page 24 and 25: Prof. Dr. Joachim Kurtz 1 Prof. Dr.
Page 26 and 27: Alexander Christian 1 1 Institute f
Page 28 and 29: Felipe Torres 1 1 Institute for Mat
Page 30: Dr. Christoph Preuss Westfälische-
Page 33 and 34: Adaptive conflicts in protein evolu
Page 35 and 36: Transcriptomic resilience to global
Page 37 and 38: along these N gradients, we have fo
Page 40 and 41: Denise Meister 1 Harald Strauss 1 1
Page 42 and 43: Katharina Siedenberg 1 Harald Strau
Page 44: Gesellschaft für Arteriosklerosefo
Page 47 and 48: The effects of genotype and social
Page 49: Discovering the genetic background
Page 52 and 53: 52 the hIstory of the botanIcal gar
Page 54 and 55: 54 In 1913 he managed to make the g
Page 56 and 57: 56 A newly built pavilion is erecte
Page 58 and 59: 58 map & contact Botanischer Garten
Page 61 and 62: members of the mgse 61
Page 63 and 64: the mgse Junior Professor Francesco
Page 65: Schulze-Bahr, Prof. Eric Towards ev
Page 68 and 69: 68 addresses of Presenters Bohle, D
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notes 71
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