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CG123 Common mental health disorders - National Institute for ...

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Further assessment of risk and need <strong>for</strong> treatment, and routine outcome monitoringTable 26: Study in<strong>for</strong>mation table <strong>for</strong> systematic reviews of predictors of responseStudy ID DODD2004 FEKADU2009 HARDEVELD2010 MITCHELL2005 NELSON2009 POMPILI2009Predictor Biological, Clinical factors Psychosocial and Age Presence of Psychosocial andpsychosocial, clinical factors anxiety clinical factorsclinical factorsOutcome Response to Treatment response/ Recurrence of major Treatment response Response to second Medicationantidepressant readmission depressive disorder and remission/ generation adherencetreatment (MDD) recurrence of antidepressantdepression treatmentMethod used to Narrative Narrative Narrative Narrative Meta-analysis NarrativesynthesiseevidenceDesign of Preference <strong>for</strong> Observational and Naturalistic Comparative studies Randomised, Primary research,included studies clinically relevant longitudinal longitudinal study of mid- and late-life double-blind review articles andprimary research (minimum (minimum follow-up first-epsiode placebo-controlled descriptive papersarticles follow-up 6 months) 6 months and depression (minimum trials that measuredsample size of 50) sample size of 20 in adherenceeach group)Dates searched 1966 to 2004 Inception to 2008 1980 to 2008 1966 to 2004 1966 to 2006 1975 to 2009Diagnosis Depression Treatment-resistant MDD Depression Late-life depression Unipolar anddepression bipolar depressionNo. of included 95 9 (4 with relevant 27 36 primary articles 10 104studies data)Review quality High risk of bias (only Low risk bias Low risk of bias Low risk of bias Low risk of bias Moderate risk ofMEDLINE searched, bias (quality ofquality of included included studies notstudies not assessed/ assessed/reported)reported, poordescription ofmethodology)147

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