CG123 Common mental health disorders - National Institute for ...

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Methods used to develop this guideline● MEDLINE/MEDLINE In-Process● NHS EED● PsycINFO.Again, any relevant economic evidence arising from the clinical searches was alsomade available to the health economist during the same period.The search strategies were initially developed for MEDLINE before being translatedfor use in other databases/interfaces. Strategies were built up through a numberof trial searches, and through discussions of the results of the searches with the reviewteam/GDG, to ensure that all possible relevant search terms were covered.Reference ManagerCitations from each search were downloaded into Reference Manager and duplicatesremoved. Records were then screened against the inclusion criteria of the reviewsbefore being quality appraised. The unfiltered search results were saved andretained for future potential re-analysis to help keep the process both replicable andtransparent.Search filtersThe search filter for health economics is an adaptation of a pre-tested strategydesigned by the NHS Centre for Reviews and Dissemination (2007). The search filteris designed to retrieve records of economic evidence (including full and partialeconomic evaluations) from the vast amount of literature indexed to major medicaldatabases such as MEDLINE. The filter, which comprises a combination ofcontrolled vocabulary and free-text retrieval methods, maximises sensitivity (orrecall) to ensure that as many potentially relevant records as possible are retrievedfrom a search. Full details of the filter are provided in Appendix 8.Date and language restrictionsSystematic database searches were initially conducted in January 2010 up to the mostrecent searchable date, with the final re-runs carried out in September 2010. After thispoint, studies were included only if they were judged by the GDG to be exceptional(for example, the evidence was likely to change a recommendation).Although no language restrictions were applied at the searching stage, foreignlanguage papers were not requested or reviewed unless they were of particularimportance to an area under review. All the searches were restricted to researchpublished from 1995 onwards in order to obtain data relevant to current healthcaresettings and costs.Other search methodsOther search methods involved scanning the reference lists of all eligible publications(systematic reviews, stakeholder evidence and included studies from the economicand clinical reviews) to identify further studies for consideration.Full details of the search strategies and filters used for the systematic review ofhealth economic evidence are provided in Appendix 8.53
Methods used to develop this guideline3.6.2 Inclusion criteria for economic studiesThe following inclusion criteria were applied to select studies identified by theeconomic searches for further consideration:● Only studies from the Organisation for Economic Co-operation and Developmentcountries were included because the aim of the review was to identify economicinformation transferable to the UK context.● Selection criteria based on types of clinical conditions and patients as well asinterventions assessed were identical to the clinical literature review.● Studies were included provided that sufficient details regarding methods andresults were available to enable the methodological quality of the study to beassessed, and provided that the study’s data and results were extractable. Posterpresentations of abstracts were excluded.● Full economic evaluations that compared two or more relevant options andconsidered both costs and consequences (that is, cost–consequence analysis, costeffectivenessanalysis, cost–utility analysis or cost–benefit analysis), as well ascosting analyses that compared only costs between two or more interventions,were included in the review.● Economic studies were included if they used clinical effectiveness data from anRCT, a prospective cohort study, or a systematic review and meta-analysis of clinicalstudies. Studies that had a mirror-image or other retrospective design wereexcluded from the review.● Studies were included only if the examined interventions were clearly described.This involved the dosage and route of administration and the duration of treatmentin the case of pharmacological therapies, and the types of health professionalsinvolved, as well as the frequency and duration of treatment in the case of psychologicalinterventions. Evaluations in which medications were treated as a classwere excluded from further consideration.● Studies that adopted a very narrow perspective, ignoring major categories of coststo the NHS, were excluded; for example, studies that estimated exclusively drugacquisition costs or hospitalisation costs were considered non-informative to theguideline development process.3.6.3 Applicability and quality criteria for economic studiesAll economic papers eligible for inclusion were appraised for their applicability andquality using the methodology checklist for economic evaluations recommended byNICE (2009d), which is shown in Appendix 9 of this guideline. The methodologychecklist for economic evaluations was also applied to the economic models developedspecifically for this guideline. All studies that fully or partially met the applicabilityand quality criteria described in the methodology checklist were considered during theguideline development process, along with the results of the economic modellingconducted specifically for this guideline. The completed methodology checklists forall economic evaluations considered in the guideline are provided in Appendix 12.54
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Commonmental healthdisordersTHE NIC
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Further assessment of risk and need
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Summary of recommendations8.1.1.6 S
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Summary of recommendationsFigure 12
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Summary of recommendations●Genera
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Summary of recommendations8.4 STEPS
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Summary of recommendationsinclude p
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Appendices9 APPENDICESAppendix 1: S
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Appendix 1of a depressive disorder
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Appendix 1b) Assessment of anxiety
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Appendix 2APPENDIX 2:DECLARATIONS O
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Appendix 2Mr Mike BessantEmployment
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Appendix 2Personal non-pecuniary in
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Appendix 2Actions takenMr Rupert Su
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Appendix 2Personal family interestN
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Appendix 3APPENDIX 3:STAKEHOLDERS A
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Appendix 4ClinicalpopulationPeople
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Appendix 4Case identificationNo. Pr
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Appendix 5APPENDIX 5:REVIEW PROTOCO
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Appendix 7APPENDIX 7:METHODOLOGY CH
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Appendix 9APPENDIX 9:METHODOLOGY CH
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Appendix 92.10 Are all important pa
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Appendix 9case also excludes costs
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Appendix 9For consistency, the EQ-5
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Appendix 9Answer ‘yes’ if the a
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Appendix 9Answer ‘yes’ if the e
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Appendix 9Answer ‘yes’ if appro
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Appendix 10APPENDIX 10: EVIDENCE TA
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Appendix 11APPENDIX 11:HIGH PRIORIT
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Appendix 11discussion of options bu
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Appendix 13APPENDIX 13:GENERALIZED
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ReferencesAndlin-Sobocki, P., Jöns
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ReferencesBower, P., Gilbody, S., R
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ReferencesCooper, S., Smiley, E., M
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ReferencesEhlers A., Gene-Cos N. &
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ReferencesGiles, D. E., Jarrett, R.
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ReferencesHorowitz, M. J., Wilner,
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ReferencesKnapp, M. & Ilson, S. (20
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ReferencesMarks, J., Goldberg, D. P
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ReferencesNCCMH (forthcoming) Self-
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ReferencesOzer, E. J., Best, S. R.,
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ReferencesSartorius, N. (2002) Eine
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ReferencesTiemens, B. G., Ormel, J.
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ReferencesWilkinson, M. J. B. & Bar
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Glossarybeliefs and interpretations
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Glossaryto learn to become more awa
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Abbreviations12 ABBREVIATIONSADDADS
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AbbreviationsOASISOCDONSORPHQ (-A,
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