“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
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EGF receptor mutations<br />
• ErbB mutants may:<br />
– Have impaired internalization<br />
– Show decreased de-phosphorylation<br />
– Have altered affinity for gefitinib<br />
• Used the model to simulate options<br />
• Compared output with published data<br />
Adriano M Henney PhD
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