“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
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ErbB pathway model<br />
• Adopted existing models:<br />
• ERK model from Asthagiri & Lauffenburger Biotechnol<br />
Prog (2001) 17:227-239<br />
• AKT model from Hatakeyama, et al. Biochem J (2003)<br />
373: 451-463.<br />
• Adapted & further developed to include<br />
receptor trafficking:<br />
• Hendriks et al., IEE Proc.-Syst. Biol., (2006) 153: 22-33<br />
• Modelling used to:<br />
– predict therapeutic efficacy<br />
– ErbB1 mutants<br />
• understanding mechanism of action<br />
Adriano M Henney PhD
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