“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
“Top-Down” “Middle-Out” “Bottom-Up” - mcisb
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The Pharma Challenge:<br />
Can Systems Biology help?<br />
Potential Applications in Drug Discovery & Development:<br />
Target<br />
Validation<br />
Target<br />
Prioritization<br />
Pathophysiology<br />
Insights<br />
Target<br />
ID/Validation<br />
Adriano M Henney PhD<br />
Patient sub-type<br />
PK/PD optimization<br />
Lead Activity<br />
Characterization<br />
Thresholds Biomarker<br />
Identification<br />
Biomarker<br />
Identification<br />
Candidate<br />
Prioritization<br />
Candidate<br />
Selection<br />
Translational<br />
Medicine<br />
Compound<br />
Development<br />
Phase I Study<br />
Optimization<br />
Phase II Study<br />
Optimization<br />
Alternative<br />
Mechanism of Action<br />
In-licensing<br />
evaluation<br />
Clinical<br />
Development<br />
Phase III/IV<br />
Study Optimization<br />
Biomarker<br />
Identification<br />
Life Cycle<br />
Management<br />
New Medical Claim<br />
Clinical/<br />
Launch
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