Biochemie-Zentrum der Universität Heidelberg (BZH)
Biochemie-Zentrum der Universität Heidelberg (BZH)
Biochemie-Zentrum der Universität Heidelberg (BZH)
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2006). These factors were used to draw a model<br />
showing their putative sites of action (Fig. 2).<br />
We also continued to investigate the effect of PL<br />
deficiency on CNS myelination in cortex and cer-<br />
ebellum. In both regions we noted a delay in my-<br />
elination that was most conspicuous in peripheral<br />
cortical layers (Fig. 3).<br />
Fig. 3: Dysmyelination in cortex and cerebellum of P20<br />
control (+/+) and EL-deficient mice (-/-).<br />
Dysmyelination was accompanied by reduced<br />
concentrations of MBP as well as a significantly<br />
impaired nerve conduction velocity as determined<br />
in fibers of the corpus callosum (Gorgas K. et<br />
al., 2006; Liu D. et al., 2005). Whereas Nav- and<br />
Kv-channels were normally distributed, axonal<br />
swellings and formation of axon varicosities suggest<br />
defects in organelle transport and/or Ca2+signaling<br />
(Fig. 4).<br />
Fig. 4: Varicosities (arrows, and inset) in Purkinje cell<br />
axons of P45 EL-deficient mice.<br />
Selected Publications 2004 - 2007<br />
S. Wiese, T. Gronemeyer, R. Ofman, M. Kunze, C P. Grou,<br />
J. A. Almeida, M. Eisenacher, C. Stephan, H. Hayen, L.<br />
Schollenberger, T. Korosec, H. R. Waterham, W. Schliebs, R.<br />
Erdmann, J. Berger, H. E. Meyer, W. W. Just, J. E. Azevedo,<br />
R. J. A. Wan<strong>der</strong>s, B. Warscheid. 2007. Proteomic characterization<br />
of mouse kidney peroxisomes by tandem mass spectrometry<br />
and protein correlation profiling. Mol Cell Proteomics.<br />
6, 2045-57.<br />
Lay, D, K. Gorgas, W. W. Just. 2006. Peroxisome biogenesis:<br />
Where Arf and coatomer might be involved. BBAMCR, 1763,<br />
1678-1687.<br />
Jeynov B, D. Lay, F. Schmidt, S. Tahirovic, W. W. Just. 2006.<br />
Phosphoinositide synthesis and degradation in isolated rat<br />
liver peroxisomes. FEBS Lett. 580, 5917-5924.<br />
Gorgas, K, A. Teigler, D. Komljenovic, W. W. Just. 2006. The<br />
ether lipid-deficient mouse: Tracking down plasmalogen<br />
functions. BBAMCR, 1763, 1511-1526.<br />
Lay D, B. L. Grosshans, H. Heid, K. Gorgas, W. W. Just.<br />
2005. Binding and functions of ARF on mammalian and yeast<br />
peroxisomes. J Biol Chem. 280, 34489-34499.<br />
Liu D, N. Nagan, W. W. Just, C. Rodemer, T-P. Thai, R. A.<br />
Zoeller. 2005. Role of dihydroxyacetonephosphate acyltransferase<br />
in the biosynthesis of plasmalogens and nonether<br />
glycerolipids. J Lipid Res. 46, 727-735.<br />
Wilhelm Just<br />
<strong>Biochemie</strong>-<strong>Zentrum</strong> <strong>der</strong><br />
<strong>Universität</strong> <strong>Heidelberg</strong> (<strong>BZH</strong>)<br />
Im Neuenheimer Feld 328<br />
D-69120 <strong>Heidelberg</strong><br />
Phone Office: +49 (0)6221-54 4151<br />
Phone Lab: +49 (0)6221-54 5419<br />
Fax: +49 (0)6221-54 4366<br />
E-mail: wilhelm.just@bzh.uni-heidelberg.de<br />
Wilhelm Just<br />
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