62 of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells. J Biol Chem. 2004, 279(8): 6244-51. Backhaus R, Zehe C, Wegehingel S, Kehlenbach A, Schwappach B, Nickel W. Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding. J Cell Sci. 2004, 117(Pt 9):1727-36. Ulschmid JK, Rahlfs S, Schirmer RH, Becker K. Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasite Plasmodium falciparum. Central players in cellular energy metabolism. Mol Biochem Parasitol. 2004, 136(2):211-20. Gromer S, Urig S, Becker K. The thioredoxin system - from science to clinic.Med Res Rev. 2004, 24(1):40-89. Ziebuhr W, Xiao K, Coulibaly B, Schwarz R, Dandekar T. Pharmacogenomic strategies against resistance development in microbial infections. Pharmacogenomics. 2004, 5(4):361-79. Coulibaly B, Eubel J, Gromer S, Schirmer RH. Biochemistry-based health care research. Methylene blue, malaria, methemoglobin, and malnutrition. Health Research in Developing Countries (Becher H, Kouyaté B eds). Springer Verlag, Berlin-<strong>Heidelberg</strong>. 2004, 285-297. Schirmer H, Medikamente für die Armen - Die Biomedizin des 21. Jahrhun<strong>der</strong>ts darf nicht nur für die Min<strong>der</strong>heit <strong>der</strong> Wohlhabenden forschen. Spektrum <strong>der</strong> Wissenschaft. 2004, 110-113. Steiner M, Schmidt H, Lindahl S, Kossel AH, Schuff-Werner P, Schirmer H. Die Entdeckung <strong>der</strong> Nukleinsäure-Bausteine: ein Beitrag zum 150. Geburtstag Albrecht Kossels, Nobelpreisträger für Physiologie o<strong>der</strong> Medizin 1910. Klinische Chemie Mitteilungen. 2004, 35(3/4):46-54. Schlieker C, Tews I, Bukau B, Mogk A. Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides. FEBS Lett. 2004, 578(3):351-6. Costagliola S, Bonomi M, Morgenthaler NG, Van Durme J, Panneels V, Refetoff S, Vassart G. Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity. Mol Endocrinol. 2004, 18(12):3020-34. Luirink J, Sinning I. SRP-mediated protein Publications targeting: structure and function revisited. Biochim Biophys Acta. 2004, 1694(1-3):17-35. Wild K, Halic M, Sinning I, Beckmann R. SRP meets the ribosome. Nat Struct Mol Biol. 2004, 11(11):1049-53. Abell BM, Pool MR, Schlenker O, Sinning I, High S. Signal recognition particle mediates posttranslational targeting in eukaryotes. EMBO J. 2004, 23(14):2755-64. Wild K, Rosendal KR, Sinning I. A structural step into the SRP cycle. Mol Microbiol. 2004, 53(2):357-63. Serrano RL, Kuhn A, Hendricks A, Helms JB, Sinning I, Groves MR. Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism. J Mol Biol. 2004, 339(1):173-83. Groves MR, Kuhn A, Hendricks A, Radke S, Serrano RL, Helms JB, Sinning I. Crystallization of a Golgi-associated PR-1-related protein (GAPR-1) that localizes to lipid-enriched microdomains. Acta Crystallogr D Biol Crystallogr. 2004, 60(Pt 4):730-2. Dobberstein B, Sinning I. Structural biology. Surprising news from the PCC. Science. 2004, 303(5656):320-2. Rosendal KR, Sinning I, Wild K. Crystallization of the crenarchaeal SRP core. Acta Crystallogr D Biol Crystallogr. 2004, 60(Pt 1):140-3. Vasiljev A, Ahting U, Nargang FE, Go NE, Habib SJ, Kozany C, Panneels V, Sinning I, Prokisch H, Neupert W, Nussberger S, Rapaport D. Reconstituted TOM core complex and Tim9/ Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranes. Mol Biol Cell. 2004, 15(3):1445-58. Dietrich LE, Ungermann C. On the mechanism of protein palmitoylation. EMBO Rep. 2004, 5(11):1053-7. Dietrich LE, Gurezka R, Veit M, Ungermann C. The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion. EMBO J. 2004, 23(1):45-53. Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D’Esposito M, Galli T, Filippini F. Longins and their longin domains: regulated
SNAREs and multifunctional SNARE regulators. Trends Biochem Sci. 2004, 29(12):682-8. Faergeman NJ, Fed<strong>der</strong>sen S, Christiansen JK, Larsen MK, Schneiter R, Ungermann C, Mutenda K, Roepstorff P, Knudsen J. Acyl-CoAbinding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae. Biochem J. 2004, 380(Pt 3):907-18. Theis MG, Knorre A, Kellersch B, Moelleken J, Wieland F, Kolanus W, Famulok M. Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2. Proc Natl Acad Sci U S A. 2004, 101(31):11221-6. Schneiter R, Brügger B, Amann CM, Prestwich GD, Epand RF, Zellnig G, Wieland FT, Epand RM. Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes. Biochem J. 2004, 381(Pt 3):941-9. Wegmann D, Hess P, Baier C, Wieland FT, Reinhard C. Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals. Mol Cell Biol. 2004, 24(3):1070-80. Brügger B, Graham C, Leibrecht I, Mombelli E, Jen A, Wieland F, Morris R. The membrane domains occupied by glycosylphosphatidylinositolanchored prion protein and Thy-1 differ in lipid composition. J Biol Chem. 2004, 279(9):7530-6. B. Brügger and F. T. Wieland. Mechanismen <strong>der</strong> COPI-Vesikelbiogenese. Biospektrum I. 2004, 30-33. Publications 63
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BZH Report 2004 - 2007
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Introduction 4 Research Groups Mich
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During the past four years the BZH
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Fig. 1: Interconnected negative and
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activated and frq transcription set
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