RIBOFLAVIN

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Documentazione distribuita da A.I.CHE. - Associazione Italiana CHEratoconici ONLUS (www.assocheratocono.org)• The clinical evidence that diabeticpatients are rarely affected bykeratoconus supported these studies.In affected patients the natural cross-linking effect of glucose produces anincrease of corneal resistance(Maillard’s reaction).• An increase in corneal resistance, dueto natural collagen glycosilation,occurs also with ageing.
Documentazione distribuita da A.I.CHE. - Associazione Italiana CHEratoconici ONLUS (www.assocheratocono.org)Cross-Linkingtypes• Enzymatic Cross-linkinglinking:-thephysiological cross-linkingis performed byLysyl-oxidaseenzyme-theAGEs (AdvancedGlycation Endproducts) areliable for cross-linkingin diabetes• Chemical Cross-linkinglinking:-glutaraldehyde, formaldehyde• Photochemical Cross-linkinglinking:-UVrays, ionizing radiation• Photo-oxidativeoxidative Cross-linkinglinking:-<strong>RIBOFLAVIN</strong>- UVA
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