PROTOCOLS

ALS PRACTITIONER PROTOCOLS2 ADRENERGIC STIMULANTSDESCRIPTION:• Classification• Schedule: Bronchodilators: 2 – Aerosol3 – Inhalant solutions and unit dose vials4 – AmpoulesPHARMACOLOGICAL ACTION:• Hexoprenaline, Fenoterol & Salbutamol are selective 2 stimulantsacting on the 2 receptors in the lungs:bronchial smooth muscle : broncho-dilation• At higher/repeated dosages, the systemic absorption progressivelyincreases, thus acting on other organs with 2 receptors e.g.- Skeletal muscle : contraction- Vascular smooth muscle : vasodilation- Bladder smooth muscle : relaxation- Intestinal smooth muscle : decreased peristalsis- Uterine smooth muscle : tocolysis- Glycogen stores : break down of glycogen to glucose• At higher/repeated dosages, the selectivity is also progressively lostand 1 effects (myocardium) are experienced:- Positive inotrope- Positive chronotrope- Positive dromotrope- Increased myocardial oxygen consumptionPHARMACO-KINETICS:• Onset of action• Duration of action: 5-15 minutes: 3-6 hours38 SEPTEMBER 2006