Pharmacology

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Dose Response Relationships• Threshold (minimal) dose– Least amount needed to to produce desired effects• Maximum effect– Greatest response produced regardless of of doseused
Dose Response RelationshipsBEffectATherapeuticEffectDoseWhich drug has the lower threshold dose?Which has the greater maximum effect?ABB
Page 1 and 2: PharmacologyPharmacokineticsPharmac
Page 3 and 4: Pharmacokinetic Processes“LADME
Page 5 and 6: Absorption• Movement from adminis
Page 7 and 8: Membranes and AbsorptionSmall,uncha
Page 9: 4. System 3. 2. 1. System Stress Sy
Page 12 and 13: A real live, actual clinicalquestio
Page 14 and 15: Moral of the story...Acidic drugs a
Page 16 and 17: Distribution• Rate of perfusion
Page 18 and 19: Blood-Brain Brain BarrierThe blood
Page 20 and 21: Hepatic ‘First-Pass’Metabolism
Page 22 and 23: Active Tubular TransportProbenecid
Page 24 and 25: How will this affect phenobarbitalr
Page 26 and 27: Biological Half-life life (t 1/2 )
Page 28 and 29: Administration Routes• Intravenou
Page 30 and 31: Pharmacodynamics• The biochemical
Page 32 and 33: Receptor InteractionsLock and key m
Page 34 and 35: Receptor InteractionsCompetitiveInh
Page 36 and 37: Non-receptor Mechanisms• Actions
Page 38 and 39: Non-receptor Mechanisms• Changing
Page 40 and 41: Non-receptor Mechanisms• Anti-met
Page 42 and 43: Time Response RelationshipsMaximal
Page 44 and 45: Dose Response Relationships• Pote
Page 48 and 49: Dose Response Relationships• Load
Page 50 and 51: Therapeutic IndexWhy don’t we use
Page 52 and 53: Factors Altering DrugResponses• E
Page 54 and 55: Influencing factors• Genetic effe
Page 56 and 57: Geriatric Patients• Chronic disea
Page 58 and 59: Web Resources• Merk Manual: Facto

Pharmacology

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