A review of production technologies for ... - World Health Organization
A review of production technologies for ... - World Health Organization
A review of production technologies for ... - World Health Organization
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Influenza vaccine <strong>production</strong> <strong>technologies</strong><br />
Figure 1: Timelines <strong>for</strong> establishing influenza vaccine <strong>production</strong> facilities<br />
Inactivated vaccine,<br />
egg-based<br />
manufacturing<br />
Inactivated vaccine,<br />
cell-culture-based<br />
manufacturing<br />
Live-attenuated<br />
vaccine,<br />
egg-based<br />
manufacturing<br />
Year 1 Year 2 Year 3 Year 4 Year 5<br />
Establish lab scale process<br />
& produce clinical lot<br />
Establish lab scale process<br />
& produce clinical lot<br />
Lab scale process<br />
& clinical lot<br />
Reg. approval &<br />
phase 1 trial<br />
Reg. approval & phase 1<br />
trial<br />
Reg. approval &<br />
phase 1 trial<br />
Scale-up &<br />
validate<br />
Build and equip large scale facility<br />
Build and equip large scale facility<br />
Seasonal vaccine<br />
<strong>production</strong><br />
Page 31 <strong>of</strong> 34<br />
Validate largescale<br />
facility<br />
Seasonal vaccine<br />
<strong>production</strong><br />
Validate large-scale facility<br />
Seasonal vaccine<br />
<strong>production</strong>
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