A review of production technologies for ... - World Health Organization
A review of production technologies for ... - World Health Organization
A review of production technologies for ... - World Health Organization
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Influenza vaccine <strong>production</strong> <strong>technologies</strong> 20 December 2006<br />
8 Live-attenuated influenza vaccines: cell-culture-based manufacture. ............... 23<br />
8.1 Introduction................................................................................................................. 23<br />
8.2 LAIV <strong>production</strong> in cell-culture: summary................................................................... 23<br />
9 Production <strong>of</strong> influenza vaccines in chicken-embryo fibroblasts....................... 24<br />
9.1 Introduction................................................................................................................. 24<br />
9.2 Laboratory scale ......................................................................................................... 24<br />
9.2.1 Manufacturing process and resource required ...........................................................24<br />
9.3 Industrial scale............................................................................................................ 24<br />
9.3.1 Manufacturing process ...............................................................................................24<br />
9.3.2 Resource required......................................................................................................24<br />
9.4 LAIV <strong>production</strong> in CEFs; summary ........................................................................... 24<br />
9.4.1 General considerations...............................................................................................24<br />
9.4.2 Advantages ................................................................................................................25<br />
9.4.3 Disadvantages............................................................................................................25<br />
9.4.4 Outstanding issues and questions..............................................................................25<br />
10 Conclusions .............................................................................................................. 25<br />
10.1 Egg-based manufacture <strong>of</strong> IIV ............................................................................... 27<br />
10.2 Cell-culture-based manufacture <strong>of</strong> IIV.................................................................... 27<br />
10.3 Egg-based manufacture <strong>of</strong> LAIV ............................................................................ 27<br />
10.4 Action points and next steps .................................................................................. 28<br />
11 References................................................................................................................. 29<br />
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