18 Annual Meeting Society of Virology - Gesellschaft für Virologie ...

18 th Annual Meeting
Society of Virology
Heidelberg, Germany
March 5-8, 2008
In cooperation with DVV e.V.
Hygiene-Institut Deutsches
Universitätsklinikum Krebsforschungszentrum
Heidelberg DKFZ Heidelberg
I

Imprint
Convenors
Prof. Dr. Ralf Bartenschlager, Hygiene-Institut, Universitätsklinikum Heidelberg
Prof. Dr. Lutz Gissmann, Deutsches Krebsforschungszentrum
Prof. Dr. Hans-Georg Kräusslich, Hygiene-Institut, Universitätsklinikum Heidelberg
Organization
GNW gGmbH, Heidelberg
Layout, Abstract Management
Dr. Antje Keppler, Hygiene-Institut, Universitätsklinikum Heidelberg
Online Abstract Submission and Selection System
Printed by
Neumann Druck, Heidelberg
Editorial Deadline
February 5, 2008
Mathias Halama, www.system08.de, Heidelberg
Please note: Citations of abstracts are only permitted with the corresponding
author’s authorization.
© All rights reserved.
II

Table of Contents
Contents
Maps IV
Welcome VI
Convenors VII
Scientific and organizing committee VII
Executive Committee GfV X
GfV study groups XI
Business meetings of GfV XI
Keynote and Lunch Symposia Speakers XIV
Chairpersons XIV
Poster Prize Committee XV
Sponsors and exhibiting companies XVI
General Information XIX
Scientific Programme
Wednesday, March 5, 2008 XXIII
Thursday, March 6, 2008 XXIV
Friday, March 7, 2008 XXVI
Saturday, March 8, 2008 XXVIII
Workshops – Oral presentations
Abstracts
Author Index
III
XXIX
XLIX
p. 526

Maps
Map: Congress Venue – Neuenheimer Feld
IV

Maps
Map: Heidelberg – Neuenheimer Feld, Main Station (HBF) and Altstadt
V

Welcome
Welcome to the 18 th Annual Meeting of the GfV –
Society of Virology
Dear Colleagues,
On behalf of the Organizing Committee we welcome you to the 2008 annual meeting of
the Society of Virology (GfV). This meeting has been organised by virologists working at
the Hygiene-Institute of the Heidelberg University Hospital and at the German Cancer
Research Center (DKFZ).
With approximately 800 participants and 530 submitted abstracts this meeting reflects
the strength of experimental virology in Germany, Switzerland and Austria and the
important role of the Society of Virology as home of virology in these countries. We are
convinced that the scientific programme of this meeting will provide many new ideas and
stimulating discussions - be it in response to lectures by invited speakers, as a result of
participating in the lunch symposia on recent developments in imaging technologies and
HPV vaccination, after listening to submitted talks or after studying one of the many
posters. There will also be many opportunities for setting up new collaborations and
renewing old links. In this context we would also like to point out that various committees
and study groups will have their individual meetings during this conference as indicated
in the programme. If you wish to participate in one of these study groups please join
their discussions. If you are thinking of forming study groups, this could be brought up at
the Annual General Meeting of the GfV on Thursday evening.
Organizing this meeting would not have been possible without the generous sponsorship
of many companies whose names are listed in this programme. Furthermore, we thank
the many unnamed colleagues and students from all participating institutions whose
active support and energy made this meeting possible. We are looking forward to an
exciting conference and a pleasant reunion with our fellow virologists. We sincerely hope
that you will have a great time in Heidelberg and a most enjoyable and stimulating
meeting.
Ralf Bartenschlager Lutz Gissmann Hans-Georg Kräusslich
VI

Convenors
General Information
Ralf Bartenschlager (Hygiene-Institut, Universitätsklinikum Heidelberg)
Lutz Gissmann (Deutsches Krebsforschungszentrum, Heidelberg)
Hans-Georg Kräusslich (Hygiene-Institut, Universitätsklinikum Heidelberg)
Scientific and organizing committee Heidelberg
Ralf Bartenschlager
Oliver Fackler
Lutz Gissmann
Thomas Holz
Antje Keppler
Oliver Keppler
Hans-Georg Kräusslich
Jacomine Krijnse-Locker
Martin Löchelt
Volker Lohmann
Barbara Müller
Martin Müller
Dirk Nettelbeck
Stephan Urban
Organization by
GNW gGmbH, Heidelberg
VII

VIII

General Information
Executive Committee of the Gesellschaft für Virologie GfV
President Nikolaus Müller-Lantzsch (Homburg)
1. Vice president Franz Xaver Heinz (Wien)
2. Vice president Ulrich Koszinowski (München)
Former presidents
Hans-Dieter Klenk (Marburg)
Otto Haller (Freiburg)
Bernhard Fleckenstein (Erlangen)
Secretary Thomas Mertens (Ulm)
Treasurer Detlev Krüger (Berlin)
Advisory Board Ralf Bartenschlager (Heidelberg)
Otto Haller (Freiburg)
Detlev Krüger (Berlin)
Thomas Mettenleiter (Insel Riems)
Susanne Modrow (Regensburg)
Karin Mölling (Zürich)
Matthias J. Reddehase (Mainz)
Axel Rethwilm (Würzburg)
Hans Will (Hamburg)
Hans Wolf (Regensburg)
For more information and for becoming a member – go to: www.g-f-v.org
Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten DVV e.V.
President Peter Wutzler (Jena)
X

Meetings of GfV - study groups
Wednesday, March 5 th , 19.00
KIP-SR1
Thursday, March 6 th , 13.00
KIP-SR1
Friday, March 7 th , 13.45
Bib-Virology (INF 324)
General Information
Meetings of the Society of Virology GfV
Wednesday, March 5 th
GfV Board Meeting (19.00 at DKFZ, room K1/K2)
Thursday, March 6 th
General assembly (19.00, CH – Großer Saal)
Cell Biology of Virus Infection
Kay Grünewald, Stephan Urban
Virusvektoren und Gentherapie
Toni Cathomen, Jens Bohne
Immunbiologie von Virusinfektionen
Sigrun Smola
Friday, March 7 th
Conference Dinner (20.00, Zeughaus – Altstadt Heidelberg)
Abbreviations
Bib-Virology Seminar room Virology (4th floor, room 404, INF 324)
CH Chemie Hörsaalgebäude (INF 252)
DKFZ Deutsches Krebsforschungszentrum
DVV Deutsche Vereinigung zur Bekämpfung der
Viruskrankheiten
GfV Gesellschaft für Virologie
INF Im Neuenheimer Feld
KIP Kirchhoff Institute for Physics (INF 227)
SR1 Seminar room 1 (KIP, INF 227)
XI

General Information
XII

General Information
XIII

Keynote Speakers
Paul Ahlquist (Madison)
John Doorbar (London)
Lynn Enquist (Princeton)
Katherine A. High (Philadephia)
Yoshihiro Kawaoka (Madison)
Stanley M. Lemon (Galveston)
Grant McFadden (Gainesville)
Walther Mothes (New Haven)
Mario Stevenson (Worcester)
Lunch Symposia Speakers
Daniel Gerlich (Zürich)
Stefan Hell (Göttingen)
Peter Hillemanns (Hannover)
Hans Ikenberg (Frankfurt)
Ulrich Nienhaus (Ulm)
Sigrun Smola (Köln)
General Information
Chairpersons Keynote Lectures and Workshops
Martin Beer (Greifswald)
Paul Becher (Gießen)
Jens Bohne (Hannover)
Wolfram Brune (Berlin)
Maren Eggers (Stuttgart)
Anja Ehrhardt (München)
Christine Ehrhardt (Münster)
Armin Ensser (Erlangen)
Dirk Grimm (Heidelberg)
Kay Grünewald (München)
Jürgen Haas (München)
Eberhard Hildt (Freiburg)
Daniela Huzly (Freiburg)
Rolf Kaiser (Köln)
Hans-Dieter Klenk (Marburg)
Barbara Klupp (Greifswald)
Ulrich Koszinowski (München)
Maik Lehmann (Heidelberg)
Astrid Meerbach (Jena)
Elke Mühlberger (Marburg)
Jan Münch (Ulm)
Carsten Münk (Langen)
Ingo Nindl (Berlin)
Klaus Osterrieder (Berlin)
Stefan Pöhlmann (Hannover)
Ulrike Protzer (München)
Jaques Rohayem (Dresden)
Mario Schelhaas (Zürich)
Thomas Schulz (Hannover)
Beate Sodeik (Hannover)
Frank Stubenrauch (Tübingen)
Gerd Sutter (Langen)
Volker Thiel (St. Gallen)
Norbert Tautz (Gießen)
Alexandra Trkola (Zürich)
Alexander Weber (Heidelberg)
Friedemann Weber (Freiburg)
Holger Zimmermann (Wuppertal)
XIV

Poster Prize Committee
Awards
Nicole Fischer (Hamburg)
Michael Schindler (Hamburg)
Christian Sinzger (Tübingen)
Jürgen Stech (Marburg)
General Information
Löffler-Frosch Medal
donated by the Gesellschaft für Virologie (GfV)
Saturday, March 8 th (13:00, CH – Großer Saal)
Awardee: Heinz Schaller (Heidelberg)
Löffler-Frosch Award
donated by the Gesellschaft für Virologie (GfV)
Wednesday, March 5 th (14:50, CH – Großer Saal)
Awardee: Oliver Keppler (Heidelberg)
XV

General Information
Sponsors and exhibiting companies
The organizers wish to thank the following companies for their valuable sponsoring and
their participation in the industrial exhibition.
Sponsors
GlaxoSmithKline GmbH & Co. KG
Theresienhöhe 11, 80339 München, Germany
Sanofi Pasteur MSD GmbH
Paul-Ehrlich-Straße 1, 69181 Leimen, Germany
febit
Im Neuenheimer Feld 519, 69120 Heidelberg
Abbott Molecular GmbH & Co. KG
Max-Planck-Ring 2, 65205 Wiesbaden, Germany
bioMérieux Deutschland GmbH
Weberstrasse 8, 72622 Nürtingen
XVI
Category
Platinum
Platinum
Gold
Silver
Silver

General Information
XVII

Exhibiting companies
in alphabetical order
4Titude LTD.
Max-Dohrn-Straße 10, 10589 Berlin
General Information
Abbott GmbH & co. KG Diagnostik, Molecular
Max-Planck-Ring 2, 65205 Wiesbaden
Acris Antibodies
Im Himmelreich 11, 32120 Hiddenhausen
Biocat GmbH
Im Neuenheimer Feld 581, 69120 Heidelberg
Bioline GmbH
Im Biotechnologiepark TGZ 2, 14943 Luckenwalde
Dade Behring Vertriebs GmbH
Ludwig Erhard Straße 12, 65760 Eschborn
Febit Biomed GmbH
Im Neuenheimer Feld 519, 69120 Heidelberg
Greiner Bio-One GmbH
Maybachstraße 2, 72636 Frickenhausen
GlaxoSmithKline GmbH & Co. KG
Theresienhöhe 11, 80339 München
Integra Biosciences GmbH
Ruhberg 4, 35463 Fernwald
Lehmanns Fachbuchhandlung GmbH
Im Neuenheimer Feld 370, 69120 Heidelberg
New England Biolabs GmbH
Brüningstarße 50, Geb. G810, 65926 Frankfurt am Main
Olympus Deutschland GmbH
Wendenstraße 14-18, 20097 Hamburg
PAA Laboratories GmbH
Unterm Bornrain 2, 35091 Cölbe
Qiagen Hamburg GmbH
Königsstraße 4a, 22767 Hamburg
Roche Diagnostics GmbH
Sandhoferstraße 116, 68305 Mannheim
Serva Electrophoresis GmbH
Carl-Benz-Straße 7, 69115 Heidelberg
XVIII

General Information
General Information
For more detailed information, please visit our websites:
http://www.virology2008.de
http://www.g-f-v.org
Registration
You can register on-site for the whole conference package. We do not offer registrations
for single days. For on-site registration you can pay cash or by credit-card. Proof of
student status is required.
Participation Fees: On-site Registration
Full registration 200 €
GfV Member 140 €
Undergraduate / PhD students 75 €
The participation fee includes:
• Participating in the scientific programme
• Programme/Abstract book
• Congress documents
• Kombi-Ticket for public transport
• Coffee/tea/snacks during morning and afternoon breaks
Registration Counter
Wednesday, March 5 th , 2008 10:00 – 18:00
Thursday, March 6 th , 2008 09:00 – 18:00
Friday, March 7 th , 2008 09:00 – 18:00
Saturday, March 8 th , 2008 09:00 – 14:00
Name Badge
Your personal name badge should be worn during the whole congress. It also includes
the Kombi-Ticket for the public transport in and around Heidelberg (VRN).
Oral presentations
IMPORTANT: Only abstracts whose presenting authors are registered and who have
paid the participation fees can be considered for oral or poster presentations!
The chairmen of the workshops have evaluated all submitted abstracts for oral
presentations. Authors were informed about acceptance of their abstract for an oral
presentation.
The congress language is English. The duration of an oral presentation is limited to 10
minutes plus 5 minutes discussion. All lecture halls will be equipped with a beamer and
a computer. You are requested to bring your presentation on a memory stick or on a
CD-ROM. Personal laptops will not be allowed.
XIX

General Information
Please bring your CD-ROM or your memory stick to the media check-in in the CHEMIE -
seminar room at least two hours prior to your session. For morning sessions you should
provide your presentation already the evening before (before 5 pm). Please do not use
Windows Vista for preparing your presentation (the presentation has to be compatible
with Office 2003).
All presentations will be deleted after the conference.
Poster presentations
All submitted abstracts that have not been selected for oral presentation are presented
as posters. The poster exhibition will take place in the KIP. The poster format should be
A0 (width 0.9 m and height 1.3 m). Larger posters cannot be mounted on the poster
boards. We will have 2 poster exhibitions due to limited space:
Poster session I – Thursday 14:30 – 16:30 h: the posters should be mounted on
Wednesday 10:00 – 15:00 h and removed directly after the first poster session. Note
that posters which have not been removed on Thursday, 18:00 h, will be taken down.
Poster session II – Friday 13:45 – 15:45 h: the posters should be mounted on
Thursday (18:00 – 19:00) and Friday (9:00 – 10:00) and removed on Saturday. Posters
that are not removed until 15:00 will be taken down.
Lunch Symposia
The two lunch-symposia are free of charge, but each of them is restricted to 100
participants only. Therefore, an online-registration was compulsory. Upon successful
registration you will receive a lunch symposium ticket along with your personal congress
documents.
Conference Dinner / Banquet
The Banquet will take place on Friday March 7 th , 2008 at 20:00 at the Zeughaus in
Heidelberg/Altstadt. It is restricted to 450 participants only. Therefore, an onlineregistration
was compulsory. You will receive the banquet ticket along with your personal
conference documents. A party will be organized in the neighbouring “Lesecafé” to
conclude the evening.
Food and Beverages
During the coffee breaks, coffee and tea with small snacks will be offered without
charge. For lunch breaks you can either take the opportunity to go to the Congress
Buffet organized in the Mensa, or visit one of the small restaurants you will find going
from the Mensa in direction to the DKFZ (German Cancer Research Center), but here
the seating is very limited. In the Mensa, a buffet will be reserved for congress
participants exclusively. Mensa tokens will be sold on-site at the registration desk.
If you booked the tokens online, you will receive them along with your personal congress
documents.
Get together
On Wednesday (March 5 th , 2008) at 18:00 h we will organize a get-together for everyone
in the Chemie-Foyer. The registration fee includes this event.
XX

General Information
Continuous Medical Education
The Annual Meeting of the GfV is accredited by the Medical Chamber Baden-
Württemberg as follows:
Wednesday, March 5 th , 2008 3 points
Thursday, March 6 th , 2008 6 points
Friday, March 7 th , 2008 6 points
Saturday, March 8 th , 2008 3 points
Opening hours of the industrial exhibition
Wednesday, March 5 th , 2008 8:30 – 18:00
Thursday, March 6 th , 2008 8:30 – 18:00
Friday, March 7 th , 2008 8:30 – 18:00
Saturday, March 8 th , 2008 8:30 – 14:00
Hotel accommodation:
The GfV meeting organizers do not take any responsibilities for your accommodation.
If you need an accommodation, you will find information about hotels in Heidelberg and
the city here: http://www.heidelberg.de.
Youth hostel:
Heidelberg has a youth hostel close to the conference venue:
http://www.jugendherberge-heidelberg.de/
Please contact the youth hostel directly and as early as possible, as the number of
beds is limited (485 beds) and we do not have a booked contingent for this meeting.
How to reach the GfV Meeting:
The meeting will be held in the Chemiezentrum, Building 252, Neuenheimer Feld. The
Neuenheimer Feld comprises the University Hospital, the German Cancer Research
Center, the Science faculties of Heidelberg University, the Max Planck Institute for
Medical Research, the Technology Park and many other institutions.
You can reach it easily from the main station taking e.g. the tram No. 24 and from the
city center (Bismarckplatz) taking bus No. 31 and 32 (both in direction “University
hospital – Neuenheimer Feld”).
Public transport
Your personal name badge includes the Kombi-Ticket for the public transport in and
around Heidelberg (VRN). It will be valid from Wednesday March 5 th , until Saturday
March 8 th , 2008.
Parking
Please use public transport to reach the Neuenheimer Feld!!!
Parking space will be very limited in Neuenheimer Feld and liable to parking fees (ca. 5
EUR/day). Parking will be possible at the parking sites P10 – P13 (see Map p. IV)
XXI

General Information
How to get connected to the INTERNET during the GfV conference
A) With your own LAPTOP
A1. wireless
The Wireless Network should be accessible from the typical public areas inside the
CHEMIE and the KIP building (and partly also outside the building). These areas are:
the foyer, areas in front of the seminar rooms, and the main lecture halls.
To use it you just need a laptop with a wireless card.
Be sure to switch off the WEP-encryption.
Our SSID is called 'UNI-HEIDELBERG'
A2. via ethernet cable
At some places inside the KIP building we prepared public available network
connection. These are: one desk in the foyer and the areas in front of the seminar rooms
in the first floor. In both cases:
Switch ON the function „Automatic IP address assignment“ (DHCP)
the following protocols are permitted : POP3, IMAP, HTTP, HTTPS, SSH
for SMTP use as SMTP-Server: relay.uni-heidelberg.de
B. In the 'CIP-Pool' (KIP, room 01.401, first floor)
You can use one of the conference accounts to log into the terminals.
If you see the login window, then first select your preferred language:
Do that by selecting 'options' or 'Optionen' and then 'language' or 'Sprachen'.
Then log in with one of the grid-accounts (specified directly at the computer):
username(s): gast01 or gast02 or gast03 or ... or gast20
password: virology
C. If you need assistance...
If you have any problems with the computer network: you can find the computing group
in the northern section of the 3rd floor of the KIP building.
Room 03.103 phone 9131 Lothar Vörg
Room 03.106 phone 9130 Robert Weis
Room 03.102 phone 9137 Thomas von Kiedrowski
XXII

Wednesday March 5 th 2008
13:00
CH-Großer Saal
13:30 – 14:10
CH-Großer Saal
14:10 – 14:50
CH-Großer Saal
14:50 – 15:30
CH-Großer Saal
15:30 – 16:00
CH-Foyer
16:00 – 17:45
CH-Großer Saal
CH-Kleiner Saal
Zool.-Großer Saal
18:00
CH-Foyer
19:00 – 21:00
DKFZ K1/K2
Opening Remarks
Programme
Programme
Chair: Hans-Dieter Klenk (Marburg)
Plenary Talk 1:
Influenza pandemics: past and future
Yoshihiro Kawaoka (Madison)
Plenary Talk 2:
Interactions with cellular tumor suppressor proteins in the
life-cycle of hepatitis C virus
Stanley M. Lemon (Galveston)
Löffler - Frosch Award:
Towards an animal model for HIV - block-by-block
humanization of rats
Awardee: Oliver Keppler (Heidelberg)
Laudatio by Nikolaus Müller-Lantzsch (Homburg)
Coffee Break
Workshops:
Virus entry
Chairs: Stefan Pöhlmann, Mario Schelhaas
Transformation and oncogenesis
Chairs: Armin Ensser, Ingo Nindl
Clinical virology
Chairs: Astrid Meerbach, Jacques Rohayem
Get-together
GfV Board Meeting
XXIII

Thursday March 6 th 2008
8:30 – 9:10
CH-Großer Saal
9:10 – 9:50
CH-Großer Saal
9:50 – 10:30
CH-Großer Saal
10:30 – 11:00
CH-Foyer
11:00 – 12:45
CH-Großer Saal
Zool.-Großer Saal
CH-Kleiner Saal
CH-Kleiner Saal
Programme
Chair: Ulrich Koszinowski (München)
Plenary Talk 3:
The molecular biology of human papillomavirus infection
and disease
John Doorbar (London)
Plenary Talk 4:
Poxvirus tropism: the road from immune evasion to
oncolytic virotherapy
Grant Mc Fadden (Gainesville)
Plenary Talk 5:
Virus and host functions in positive-strand RNA virus
replication
Paul Ahlquist (Madison)
Coffee Break
Workshops:
Adaptive immune response and vaccination I
Chairs: Gerd Sutter, Alexandra Trkola
Viral vectors and gene therapy
Chairs: Anja Ehrhardt, Dirk Grimm
Systems biology of viral infections
Chairs: Jürgen Haas, Maik Lehmann
AND
Innovative diagnostic methods
Chairs: Maren Eggers, Daniela Huzly
XXIV

12:45 – 14:15
DKFZ K1/K2
14:30 – 16:30
KIP
16:30 – 18:45
CH-Großer Saal
Zool.-Großer Saal
Zool.-Großer Saal
CH-Kleiner Saal
19:00 – 20:00
CH-Großer Saal
Programme
Lunch Symposium 1: HPV Vaccination
Chair: Lutz Gissmann (Heidelberg)
HPV Vaccination: clinical studies
Peter Hillemanns (Hannover)
Immunobiology of human papillomavirus infections
Sigrun Smola (Köln)
Prevention of cervical cancer in the age of the HPV vaccine
Hans Ikenberg (Frankfurt)
Sponsored by GlaxoSmithKline GmbH and Sanofi-Pasteur
MSD
Poster Session I
Workshops:
Innate immune response
Chairs: Alexander Weber, Friedemann Weber
Transcription and translation
Chairs: Jens Bohne, Frank Stubenrauch
AND
Viral DNA genome replication
Chairs: Wolfram Brune, Nikolaus Osterrieder
Epidemiology and zoonoses
Chairs: Martin Beer, Paul Becher
Annual general meeting GfV
XXV

Friday March 7 th 2008
8:30 – 9:10
CH-Großer Saal
9:10 – 9:50
CH-Großer Saal
9:50 – 10:15
CH-Foyer
10:15 – 12:00
CH-Großer Saal
Zool.-Großer Saal
CH-Kleiner Saal
12:15 – 13:45
DKFZ K1/K2
13:45 – 15:45
KIP
Programme
Chair: Ulrike Protzer (München)
Plenary Talk 6:
Imaging of retroviral replication in living cells
Walther Mothes (New Haven)
Plenary Talk 7:
AAV-mediated gene transfer for hemophilia: successful
transduction and limitations imposed by the immune
response
Katherine A. High (Philadelphia)
Coffee Break
Workshops:
Virus structure, assembly and egress I
Chairs: Barbara Klupp, Kay Grünewald
Antiviral therapy and resistance
Chairs: Holger Zimmermann, Rolf Kaiser
Signal transduction
Chairs: Christine Ehrhardt, Eberhardt Hildt
Lunch Symposium II: Imaging
Chair: Barbara Müller (Heidelberg)
Far-field fluorescence nanoscopy
Stefan Hell (Göttingen)
High-resolution fluorescence microscopy with novel
fluorescent protein markers
Ulrich Nienhaus (Ulm)
Automated 4-D live cell microscopy and dynamic image
processing
Daniel Gerlich (Zürich)
Poster Session II
XXVI

15:45 – 17:30
CH-Großer Saal
CH-Kleiner Saal
Zool.-Großer Saal
Programme
Workshops:
Adaptive immune response and vaccination II
Chairs: Gerd Sutter, Alexandra Trkola
Host cell factors
Chairs: Beate Sodeik, Carsten Münk
Pathogenesis and persistence I
Chairs: Jan Münch, Norbert Tautz
20:00 Conference Dinner (Zeughaus, Altstadt)
XXVII

Saturday March 8 th 2008
9:15 – 11:00
CH-Großer Saal
Zool.-Großer Saal
CH-Kleiner Saal
11:00 – 11:30
CH-Foyer
11:30 – 12:10
CH-Großer Saal
12:10 – 12:50
CH-Großer Saal
12:50 – 13:00
CH-Großer Saal
13:00 – 13:15
CH-Großer Saal
13:15 – 13:45
CH-Großer Saal
13:45 – 14:00
CH-Großer Saal
14:00
Mensa
Programme
Workshops:
Virus structure, assembly and egress II
Chairs: Barbara Klupp, Kay Grünewald
Pathogenesis and persistence II
Chairs: Jan Münch, Norbert Tautz
Viral RNA genome replication
Chairs: Elke Mühlberger, Volker Thiel
Coffee Break
Chair: Thomas Schulz
Plenary Talk 8:
Infection and spread of herpesvirus infection in the nervous
system
Lynn Enquist (Princeton)
Plenary Talk 9:
Viral attack and cellular defense
Mario Stevenson (Worcester)
Poster prizes
Löffler-Frosch Medal
Awardee: Heinz Schaller (Heidelberg)
Laudatio by Nikolaus Müller-Lantzsch (Homburg)
Die Drittmittelförderung der DFG - Kriterien für eine
erfolgreiche Antragstellung
Dr. Andreas Strecker (DFG)
Concluding remarks
Lunch buffet
XXVIII

Workshops
Workshop: Virus entry
Chairs: Stefan Pöhlmann (Hannover)
Mario Schelhaas (Zürich)
When & Where: Wednesday, March 5th, 2008
16:00-17:45
XXIX
CH - Großer Saal
1. Semen-derived Amyloid Fibrils Drastically Enhance HIV infection
*Jan Münch, Elke Rücker, Ludger Ständker, Knut Adermann, Christine
Goffinet, Oliver Keppler, Michael Schindler, Steffen Wildum, Raghavan
Chinnadurai, Devi Rajan, Walther Mothes, Wolf-Georg Forssmann, Frank
Kirchhoff
2. Adaptation of Hepatitis C Virus to Murine CD81
*Julia Bitzegeio, Eike Steinmann, Ralf Bartenschlager, Thomas
Pietschmann
3. Fine mapping of a Hepatitis B Virus (HBV) receptor binding site
through inhibition of infection with acylated envelope protein-derived
peptides
*Andreas Schulze, Alexa Schieck, Yi Ni, Walter Mier, Stephan Urban
4. Tetraspanin enriched microdomains – entry platforms for human
papillomavirus type 16
*Gilles Spoden, Kirsten Freitag, Matthias Husmann, Martin Sapp, Carsten
Lambert, Luise Florin
5. Vaccinia virus uses macropinocytosis and apoptotic mimicry to
enter host cells
*Jason Mercer, Ari Helenius
6. Kinesin-1 is required for nuclear targeting of incoming Herpes
Simplex Virus capsids
Jessica Janus, Kerstin Radtke, Katinka Döhner, André Wolfstein, Falk
Büttner, Simone Schmidt, *Beate Sodeik
7. Simian Virus 40 Depends on ER Protein Folding and Quality Control
Factors for Entry into Host Cells
*Mario Schelhaas, Johan Malmström, Lucas Pelkmans, Johannes
Haugstetter, Lars Ellgaard, Kay Grünewald, Ari Helenius
*: Presenting author
p. 2
p. 3
p. 5
p. 7
p. 4
p. 6
p. 1

Workshops
Workshop: Clinical virology
Chairs: Astrid Meerbach (Jena)
Jaques Rohayem (Dresden)
When & Where: Wednesday, March 5th, 2008
16:00-17:45
XXX
Zool. - Großer Saal
1. Molecular epidemiology of a large hantavirus outbreak in Germany,
2007
Jörg Hofmann, *Helga Meisel, Boris Klempa, Silvan M. Vesenbeckh,
Robert Beck, Detlef Michel, Jonas Schmidt-Chanasit, Rainer Ulrich,
Sebastian Grund, Gisela Enders, Detlev H. Krüger
2. New insights into BK virus phylogeny and evolution
*Andi Krumbholz , Olaf Bininda-Emonds, Renate Egerer, Roland Zell
3. Characterization of the translation strategy of the human
pathogenic sapovirus in mammalian cells
*Julia Gebhardt, Dorothea Kramer, Jacques Rohayem
4. High-throughput expression of the Varicella-Zoster Virus (VZV)
proteome for serum profiling experiments
*Armin Baiker, Angelika Lueking, Maria Vizoso Pinto, Raveendra
Pothineni, Ann Arvin, Gundula Jaeger
5. Nosocomial hepatitis C: enigmatic transmissions from patient to
patient
*Bernd Kupfer, Anna Maria Eis-Hübinger, Uwe Pöge, Hans Ulrich Klehr,
Gert Schilling, Luba Lendowski, Martin Exner, Steffen Engelhart, Ingvill
Purr, Bertfried Matz
6. Frequent detection of HHV6-, EBV- and CMV-DNA in liver biopsies
of liver transplant recipients
*Ilka Engelmann, Sven Pischke, Juliane Gösling, Cornelia Henke-
Gendo, Albert Heim
7. Prevalence and mean number of cutaneous HPV types increase
with age
Marc Gottschling, Mandy Lehmann, Anja Köhler, Eggert Stockfleth,
*Ingo Nindl
*: Presenting author
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Workshops
Workshop: Transformation and oncogenesis
Chairs: Armin Ensser (Erlangen)
Ingo Nindl (Berlin)
When & Where: Wednesday, March 5th, 2008
16:00-17:45
1. Strong induction of 4-1BB, a growth and survival promoting
receptor, in HTLV-1-infected cultured and patients’ T cells by the
viral Tax oncoprotein
*Klemens Pichler, Tarek Kattan, Juliane Gentzsch, Andrea K Kress,
Graham P Taylor, Charles M Bangham , Ralph Grassmann
2. A Role for the Kaposi’s Sarcoma Herpesvirus FLICE Inhibitory
Protein (vFLIP) in establishment of latency and the Formation of
Endothelial Spindle Cell
*Khaled Alkharsah, Antje Bürger, Oliver Dittrich-Breiholz, Michael
Kracht, Matthias Thurau, Michael Stürzl, Thomas Schulz
XXXI
CH – Kleiner Saal
3. Pro- and anti-apoptotic factors induced by Herpesvirus saimiri and
Herpesvirus ateles oncoproteins
Jill de Jong , Stefan Richter, Anja Glanz, Kerstin Wanke, Stefanie
Heinemann, Jens-Christian Albrecht, Brigitte Biesinger
4. Methylation of the Arginine-Glycine repeat of the Epstein-Barr Virus
Nuclear Antigen 2 (EBNA2) generates functionally different EBNA2
species
*Alfredo Mamiani, Stephanie Barth, Henrik Groß, Jarek Szcyrba,
Christine Hennard, Elisabeth Kremmer, Friedrich A. Grässer
5. Cell cycle independent expression of ie3 leads to G1 and G2 arrest
in MCMV infected cells
*Lüder Wiebusch, Anke Neuwirth, Linus Grabenhenrich, Sebastian
Voigt, Christian Hagemeier
6. HBV replication induces beta-catenin-signalling by activation of Src
kinases
Gesa von Olshausen, Maria Quasdorff, Carien Niessen, *Ulrike Protzer
7. Adenovirus type 5 early region 1B 55-kDa oncoprotein promotes
cell transformation by a mechanism independent from blocking
p53-activated transcription
Barbara Härtl, *Peter Wimmer, Kremmer Elisabeth, Thomas Dobner
*: Presenting author
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Workshops
Workshop: Adaptive immune response and vaccination I
Chairs: Gerd Sutter (Langen)
Alexandra Trkola (Zürich)
When & Where: Thursday, March 6th, 2008
11:00-12:45
1. A New Influenza B Live Vaccine Generated by Modification of the
Haemagglutinin Cleavage Site
*Jürgen Stech, Holger Garn, Astrid Herwig, Bianca Dauber, Thorsten
Wolff, Thomas C. Mettenleiter, Hans-Dieter Klenk
2. Protection of cats against lethal influenza H5N1 challenge
infection.
*Thomas W. Vahlenkamp, Timm C. Harder, Matthias Giese, Jens P.
Teifke, Martin Beer, Thomas C. Mettenleiter
XXXII
CH – Großer Saal
3. Cellular and humoral immune responses correlate with vaccine
protective efficacy against the 1918 (H1N1) influenza virus in
ferrets
*Veronika von Messling, Darwyn Kobasa, Stephane Pillet, Michael Gray,
Jason Gren, Shane Jones, Betty Luy, Tracy Taylor, Dominique Laddy,
David Weiner, Heinz Feldmann, Gary P Kobinger
4. Protective immunity against a retrovirus by immunisation with its
transmembrane envelope (TM) protein
Stefan Langhammer, Janine Huebner, Oswald Jarrett, Reinhard Kurth,
*Joachim Denner
5. Kinetics of CD8+ effector T cell responses and induced CD4+
regulatory T cell responses in different organs during acute
retrovirus infection
*Gennadiy Zelinskyy, Kirsten Esperstedt, Simone Schimmer, Tim
Sparwasser, Ulf Dittmer
6. Antigenic Structure of Tick-Borne Encephalitis Virus and Impact of
Quaternary Organization on the Binding of Neutralizing Monoclonal
Antibodies
*Stefan Kiermayr, Karin Stiasny, Franz X. Heinz
7. Impact of MHC class I-associated selection pressure on the
evolution of HCV NS3 in a single-source outbreak
*Joerg Timm, Manfred Wiese, Jacob Nattermann, Marina Klein, Ulrich
Spengler, Sergei Viazov, Michael Roggendorf
*: Presenting author
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Workshops
Workshop: Viral vectors and gene therapy
Chairs: Anja Ehrhardt (München)
Dirk Grimm (Heidelberg)
When & Where: Thursday, March 6th, 2008
11:00-12:45
XXXIII
Zool. – Großer
Saal
1. Evaluation of infectious laryngotracheitis virus recombinants as
vectored live vaccines against H5N1 avian influenza virus infection
of chickens
*Sophia P. Pavlova, Jutta Veits, Thomas C. Mettenleiter, Walter Fuchs
2. Equine Herpesvirus 1 (EHV-1) - a Promising Tool Regarding
Heterologous Viral Gene Delivery for Vaccination Purposes
*Helga Hofmann-Sieber, Jens Wild, Katharina Boeckl, Karsten Tischer,
Jens von Einem, Nikolaus Osterrieder, Josef Koestler, Ralf Wagner
3. Systemic transfer of delta-sarcoglycan with targeted AAV vectors
prevents heart failure in delta-sarcoglycan knock-out mice
Caroline Goehringer, Desiree Rutschow, Stefanie Schinkel, Ralf Bauer,
Raffi Bekeredjian, Dieter Weichenhan, Hugo A. Katus, Jürgen A.
Kleinschmidt, *Oliver J. Müller
4. Gene-deleted adenoviral vector genomes exist predominantly as
linear monomers: Implications for persistence of recombinant
adenoviral vectors
*Lorenz Jäger, Anja Ehrhardt
5. Effective and flexible cell entry targeting of lentiviral vectors
through pseudotyping with variant measles virus H and F proteins
Sabrina Funke, Andrea Maisner, Manuel Grez, Roberto Cattaneo,
Christian J. Buchholz, *Klaus Cichutek
6. Molecular analysis of AAV concatemers and proviruses
*Ali Nowrouzi, Karim Zaoui, Anna Schneider, Anne Arens, Manfred
Schmidt, Christof von Kalle
7. “Armed” Oncolytic Adenoviruses: Deletion of the E1B19K Gene
Modulates Oncolytic Activity But Does Not Interfere with the
Expression of Transgenes
*Stanimira Rohmer, Andrea Hesse, Christina Quirin, Dirk M. Nettelbeck
*: Presenting author
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Workshops
Workshop: Innovative diagnostic methods
Chairs: Maren Eggers (Stuttgart)
Daniela Huzly (Freiburg)
When & Where: Thursday, March 6th, 2008
11:00-12:45
XXXIV
CH – Kleiner Saal
1. Recombinant expression of all Hepatitis E Virus (HEV) antigens for
the development of novel diagnostic tools
*Andreas Osterman, Rudolf Haase, Anja Ehrhardt, Hans Nitschko,
Armin Baiker
2. Combination of native and recombinant cytomegalovirus antigens
in a new ELISA for detection of CMV-specific antibodies
*Clemens Busse, Andreas Strubel, Paul Schnitzler
3. Rapid in depth diagnostics of viral full length genomes using the
Genome Sequencer technology
*Dirk Höper, Bernd Hoffmann, Martin Beer
4. Detection of contaminations in cell lines by novel multiplex assay
*Markus Schmitt, Michael Pawlita
*: Presenting author
AND
Workshop: Systems biology of viral infections
Chairs: Jürgen Haas (München)
Maik Lehmann (Heidelberg)
When & Where: Thursday, March 6th, 2008
11:00-12:45
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CH – Kleiner Saal
1. Essential impact of NF-kappaB signaling on the H5N1 influenza A
virus mediated cytokine response
*Mirco Schmolke, Dorothee Viemann, Johannes Roth, Stephan Ludwig
2. Analysis of Intraviral Protein-Protein Interactions of the SARS
Coronavirus ORFeome by peptidescanning
*Albrecht von Brunn, Claudia Ester, Julia Schöpf, Frank Ebel, Peter
Uetz, Jürgen Haas
3. High-throughput siRNA screening to identify human host factors
involved in pathogenesis of HIV-1
Maik Jörg Lehmann, *Johannes Hermle, Kathleen Börner, Lars Kaderali,
Holger Erfle, Rainer Pepperkok, Hans-Georg Kräusslich
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Workshops
Workshop: Viral DNA genome replication
Chairs: Wolfram Brune (Berlin)
Nikolaus Osterrieder (Berlin)
When & Where: Thursday, March 6th, 2008
16:30-18:45
1. DHBV epsilon RNA mutants with drastically altered upper stem
regions are still initiation and replication competent
*Markus Gajer, Michael Nassal
2. A Four-Phase Model of Human Cytomegalovirus Chromatin
Assembly and Disassembly During Lytic Infection
*Alexandra Nitzsche, Christina Paulus, Michael Nevels
*: Presenting author
AND
Workshop: Transcription and translation
Chairs: Jens Bohne (Hannover)
Frank Stubenrauch (Tübingen)
When & Where: Thursday, March 6th, 2008
16:30-18:45
1. Epigenetic modification of Epstein-Barr virus DNA is pivotal for
viral latency and reactivation of de novo virus synthesis
*Markus Kalla, Dagmar Pich, Wolfgang Hammerschmidt
XXXV
Zool. – Großer Saal
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Zool. – Großer Saal
2. Non-covalent interaction of the cellular protein sumo with the major
HCMV transactivator IE2p86 affects its transactivation capacity and
sumoylation
*Anja Berndt, Heike Hofmann, Thomas Stamminger
3. Viral Oncogene Promoter and Cell-Specific Transcriptional
Regulation by Papillomavirus E2 Proteins
*Matthias Ottinger, Jennifer A Smith, Michal-Ruth Schweiger, Peter M
Howley
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Workshops
4. Regulated read-through at the first transcription termination site
determines viral protein levels in Borna disease virus infection
*Marion Poenisch, Sandra Wille, Peter Staeheli, Urs Schneider
5. Murine leukemia virus evolved an exceptional strategy to ensure
alternative splicing via dual attenuation of the 5’ splice site
*Daniela Zychlinski, Steffen Erkelenz, Janine Kraunus, Melanie Galla,
Nicole Fischer, Heiner Schaal, Christopher Baum, Jens Bohne
6. Re-enaction of HIV-1 alternative splicing regulation by
simultaneous application of an enhanced MS2- and PP7-tethering
system
*Steffen Erkelenz, Sarah Rosin, Heiner Schaal
7. IRES elements –
tools for attenuation of Mononegavirales translation and
replication
*Adriane Marschalek, Stefan Finke, Martin Schwemmle, Daniel Mayer,
Bernd Heimrich, Lothar Stitz, Karl-Klaus Conzelmann
*: Presenting author
XXXVI
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Workshops
Workshop: Innate immune response
Chairs: Alexander Weber (Heidelberg)
Friedemann Weber (Freiburg)
When & Where: Thursday, March 6th, 2008
16:30-18:45
XXXVII
CH – Großer Saal
1. Defining Substrate Specificities of RIG-I and Mda5
*Marco Binder, Florian Eberle, Volker Lohmann, Alexander Dalpke, Ralf
Bartenschlager
2. Hepatitis A Virus Protein 2B Suppresses IRF-3 Activation by
Interfering with MAVS-Dependent Signaling Resulting in Inhibition
of IFN-beta
*Dajana Paulmann, Thomas Magulski, Rebecca Schwarz, Andreas
Dotzauer, Angelika Vallbracht
3. Measles virus V protein is a decoy substrate for the kinase IKKalpha
and prevents Toll-like receptor 7/9-mediated IFN induction
*Christian Pfaller, Karl-Klaus Conzelmann
4. Interferon-antagonistic ML protein of Thogoto virus targets general
transcription factor IIB
*Carola Vogt, Ellen Preuß, Daniel Mayer, Martin Schwemmle,
Friedemann Weber, Georg Kochs
5. Inhibition of specific cytokine secretion pathways in plasmacytoid
dendritic cells (pDC) by PCV2
*Carole Balmelli, Nadja Peduto, Artur Summerfield, Kenneth
McCullough
6. Inhibition of the IFN-mediated signaling by the M1 protein of
influenza A Virus
*Jovan Pavlovic (1), Bettina Oberle (1), Karin Moelling (1)
7. Neutralization of PKR by the influenza B virus NS1 protein:
Evidence for a crucial NS1-PKR complex that is bridged by dsRNA
Bianca Dauber, Jana Schneider, Zoe Waibler, Ulrich Kalinke, *Thorsten
Wolff
8. Interferon-lambda Contributes to Influenza Virus Resistance
*Markus Mordstein, Georg Kochs, Laure Dumoutier, Jean-Christophe
Renauld, Soren R. Paludan, Kevin Klucher, Peter Staeheli
9. Human papillomavirus type 8 early proteins deregulate immune
homeostasis in skin
Tanya Sperling, Gian Paolo Marcuzzi, Claudia Wickenhauser, Herbert
Pfister, Slawomir Majewski, *Sigrun Smola-Hess
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Workshops
Workshop: Epidemiology and zoonoses
Chairs: Martin Beer (Insel Riems)
Paul Becher (Gießen)
When & Where: Thursday, March 6th, 2008
16:30-18:45
1. PB1-F2 of German porcine and avian influenza A viruses
*Andi Krumbholz, Annett Eitner, Reimar Krieg, Hartmut Oehring, Karl-
Jürgen Halbhuber, Peter Wutzler, Roland Zell
XXXVIII
CH – Kleiner Saal
2. SARS-Coronavirus inhibits interferon induction both at pre- and the
post-transcriptional levels
*Thomas Kuri, Xiaonan Zhang, Louis Martinez-Sobrido, Adolpho García-
Sastre, Zhenghong Yuan, Friedemann Weber
3. First Germany-wide epidemiology of hantavirus infections in rodent
reservoir hosts
*Rainer G. Ulrich, Mathias Schlegel, Jonas Schmidt-Chanasit, Boris
Klempa, Marc Mertens, Daniel Masur, Thomas Büchner, Kati Sevke,
Jona Freise, Jens Jacob, Detlev H. Krüger, Rainer Oehme, Stefan O.
Brockmann, Gerald Heckel, Sandra S. Essbauer
4. Human Papillomavirus 16 is the predominant type etiologically
involved in penile squamous cell carcinoma
Daniëlle A.M. Heideman, *Tim Waterboer, Michael Pawlita, Pien Delisvan
Diemen, Ingo Nindl, Joost A. Leijte, Johannes M.G. Bonfrer, Simon
Horenblas, Chris J.L.M. Meijer, Peter J.F. Snijders
5. Evidence of Interspecies Transmission and Reassortment
Among Avian Group A Rotaviruses
Thomas Schumann, Helmut Hotzel, Peter Otto, *Reimar Johne
6. First isolation and genetic characterization of two tick-borne
encephalitis viruses in Germany since 30 years
*Sandra Essbauer, Gudrun Zöller, Astrid Thomas, Lothar Zöller, C
Klaus, Jochen Suess, B Stark, Martin Pfeffer, Gerhard Dobler
7. Characterisation of a E2-protein mutant of Chikungunya virus and
analysis of the influence of an opal stop codon by a novel
infectious cDNA clone
*Klaus Grywna, Pfefferle Susanne, Nadine Petersen, Christian Drosten
8. Application of rapid pyrosequencing assays for detection of cocirculating
variants of influenza A/H3N2 viruses
Marianne Wedde, Claudia Langnick, *Brunhilde Schweiger
9. Phylogenetic analysis of autochthonous HEV infections in
Germany
*Sven Schimanski, Ole Wichmann, Jürgen Wenzel, Annelie Plentz,
Judith Koch, Klaus Stark, Wolfgang Jilg
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Workshops
Workshop: Virus structure, assembly and egress I
Chairs: Kay Grünewald (München)
Barbara Klupp (Insel Riems)
When & Where: Friday, March 7th, 2008
10:15 – 12:00
XXXIX
CH – Großer Saal
1. Dissecting the Role of Cellular Factors in Retroviral Budding using
Heterodimerizer-mediated Virus-Host Protein Interaction
*Stefanie Jäger, Ivonne Morales, Anja Habermann, Hans-Georg
Kräusslich
2. The nuclear egress complex of human cytomegalovirus: a network
of lamina-associated proteins and protein kinases
*Jens Milbradt, Sabrina Auerochs, Manfred Marschall
3. Systemic screen for dominant negative mutants of M53 gene
reveals effects on both DNA packaging and nuclear egress
*Mirela Popa, Zsolt Ruzsics, Christopher Buser, Paul Walther, Ulrich H.
Koszinowski
4. Concomitant deletion of the pUL11 and gM proteins from herpes
simplex virus 1 does not severely impair virion maturation
*Tobias Leege, Walter Fuchs, Martina Kopp, Harald Granzow, Barbara
G. Klupp, Thomas C. Mettenleiter
5. Parvovirus egress from the infected cell: the role of gelsoline.
*Séverine Bär, Jean Rommelaere, Jürg Nüesch
6. Hepatitis B virus core protein point mutations allowing capsid
formation but blocking packaging of the pregenome/reverse
transcription complex
Alexander Pairan, *Volker Bruss
7. Functionally distinct subtypes of the human hepatitis B virus can
be separated by their heparin binding competence
*Stefan Seitz, Caroline Gähler, Anke Ostertag, Andreas Schulze,
Stephan Urban
*: Presenting author
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Workshops
Workshop: Antiviral therapy and resistance
Chairs: Rolf Kaiser (Köln)
Holger Zimmermann (Wuppertal)
When & Where: Friday, March 7th, 2008
10:15 – 12:00
XL
Zool. – Großer Saal
1. Susceptibility to antiviral drugs of influenza A viruses circulating in
Germany between 1998 and 2007
*Susanne Duwe, Manuela Friedrich, Timm Harder, Brunhilde Schweiger
2. Cox inhibitors; a potential new way to treat HCMV disease
*Joerg Schroeer, Thomas E. Shenk
3. Characterisation of hepatitis C virus variants resistant to the
NS3/4A protease inhibitor telaprevir (VX-950)
*Anna-Lena Gamer, Jennifer Schmitt, Artur Kaul, Ralf Bartenschlager
4. Analysis of Integrase Inhibitor (INI) resistance of HIV-1 Group M in
ART-naïve and -experienced but INI-naïve patients in Germany
Nadine Sichtig, *Martin Däumer, Stefan Esser, Ulf Dittmer, Eugen
Schülter, Mark Oette, Stefan Reuter, Gerd Fätkenheuer, Jürgen
Rockstroh, Herbert Pfister, Rolf Kaiser
5. Comparison of the Slopes of HIV-1 Drug Response Curves to
Antiretrovirals - Addressing NRTI Drug Potency
*Hauke Walter, Karin Metzner
6. Determination of HIV-1 coreceptor preference – Genotype vs.
phenotype
*Martin Obermeier, Stephan Neifer, Thomas Berg
7. The NF-kappaB-inhibitor SC75741 efficiently blocks influenza virus
propagation in vitro and in vivo without the tendency to induce
resistant virus var
*Stephan Ludwig, Christina Ehrhardt, Karoline Droebner, Andrea
Rückle, Carina Banning, Eike Hrincius, Katharina Hoppe, Johann Leban,
Stefan Strobl, Daniel Vitt, Oliver Planz
*: Presenting author
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Workshops
Workshop: Signal transduction
Chairs: Christine Ehrhardt (Münster)
Eberhard Hildt (Freiburg)
When & Where: Friday, March 7th, 2008
10:15 – 12:00
XLI
CH – Kleiner Saal
1. The Epstein-Barr virus oncoprotein LMP1 exploits TRADD for
signaling by masking its apoptotic activity
Frank Schneider, Julia Neugebauer, Janine Griese, Helmut Kutz, *Arnd
Kieser
2. EBV’s latent membrane protein 2A mimics BCR signaling
*Stephanie Medele, Liudmila Matskova, Dagmar Pich, Christoph
Mancao, Wolfgang Hammerschmidt
3. Towards the identification of the GEF activity in the Nef-Pak2
complex
*Susanne Rauch, Kati Pulkkinen, Kalle Saksela, Oliver T. Fackler
4. Absence of apoptosis in Ebola virus-infected cells is not based on
activation of cellular survival signalling pathways
*Judith Küsters, Melanie N. Grosch, Elke Mühlberger
5. Inhibition of HCV replication by Sorafenib/Nexavar: therapeutic
potential of targeting c-Raf
*Kyoshi Himmelsbach, Daniel Sauter, Thomas Baumert, Eberhard Hildt
6. Phosphorylation of the influenza A virus PB1-F2 protein by PKC is
required for efficient virus propagation
*David Mitzner, Igor Mazur, Nicole Studtrucker, Andre Eissmann,
Darisuren Anhlan, Ludmilla Wixler, Josef Wissing, Lothar Jaensch,
Karsten Bruns, Alok Sharma, Victor Wray, Peter Henklein, Stephan
Ludwig, Ulrich Schubert
7. Role of hypercytokinemia in the pathogenesis of H5N1 influenza
virus infection in mice with altered NF-kappaB signalling pathway
*Karoline Droebner, Sarah Reiling, Mathias Buettner, Oliver Planz
*: Presenting author
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Workshops
Workshop: Host cell factors
Chairs: Carsten Münk (Langen)
Beate Sodeik (Hannover)
When & Where: Friday, March 7th, 2008
15:45 – 17:30
XLII
CH – Kleiner Saal
1. Interaction of SARS-CoV Orf7a with the proapoptotic BH3-only
protein bik reduces apoptosis
*Claudia Diemer, Martha Schneider, Hermann Schätzl, Sabine Gilch
2. Human airway trypsin-like protease (HAT) cleaves the influenza
virus hemagglutinin at the cell surface
*Eva Böttcher, Mikhail Matrosovich, Tatyana Matrosovich, Hans-Dieter
Klenk, Wolfgang Garten
3. Large-scale reorganization of host cell chromatin by HCMV
infection
*Christina Paulus, Jörg Schröer, Michael Schnitzbauer, Michael Nevels
4. The human exogenous gammaretrovirus XMRV preferentially uses
the human Xpr1 receptor
*Kristin Stieler, Carol Stocking, Marc Sitbon, Martin Aepfelbacher, Nicole
Fischer
5. Model Structure of APOBEC3C Supports a Critical Role of Protein
Dimerization for Cell-Intrinsic Antiviral Activity
*Benjamin Stauch, Henning Hofmann, Martin Weisel, Klaus Cichutek,
Carsten Münk, Gisbert Schneider
6. HIV-1 Nef Interferes with Triggered Actin Remodelling to Affect Cell
Motility
*Bettina Stolp, Simone Giese, Sebastian Hannemann, Goulimari
Polyxeni, Robert Grosse, Oliver T. Fackler
7. POSH and ALIX cooperate to facilitate efficient HIV-1 budding
*Jörg Votteler, Stefan Sörgel, Liane Neumann, Nicole Studtrucker,
Torsten Walther, Elena Yavnilovitch, Daniel Taglicht, Yuval Reiss, Ulrich
Schubert
*: Presenting author
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Workshops
Workshop: Adaptive immune response and vaccination II
Chairs: Gerd Sutter (Lengen)
Alexandra Trkola (Zürich)
When & Where: Friday, March 7th, 2008
15:45 – 17:30
XLIII
CH – Großer Saal
1. A versatile dendritic cell targeting vaccine based on coronavirus
vectors induces strong and long-lasting antiviral and antitumor
immunity
*Divine Makia, Klara Kristin Eriksson, Luisa Cervantes-Barragán, Roland
Züst, Reinhard Maier, Burkhard Ludewig, Volker Thiel
2. Vaccine efficacy of recombinant Modified Vaccinia Virus Ankara
compared to adenoviral vector expressing both respiratory
syncytial virus F protein
*Sarah Schwannecke, Rebekka Kohlmann, Yasemin Süzer, Tanja
Jürgens, Bettina Tippler, Gerd Sutter, Klaus Überla, Thomas Grunwald
3. Long term immunity against novel shared MVA/smallpox T cell
epitopes as identified by differential stable isotope labeling
*Verena S. Meyer, Wolfgang Kastenmüller, Georg Gasteiger, Mirita
Franz-Wachtel, Tobias Lamkemeyer, Hans-Georg Rammensee, Stefan
Stevanovic, Dagmar Sigurdardottir, Ingo Drexler
4. Conditional antigen expression by replication deficient murine
cytomegalovirus
*Christian A. Mohr, Torsten Sacher, Zsolt Ruzsics, Ulrich H.
Koszinowski
5. Quantization and Imaging of Cytomegalovirus Immune Evasion
*Niels A. W. Lemmermann, Kerstin M. Gergely, Verena Böhm, Petra
Deegen, Matthias J. Reddehase, Natascha K. Grzimek
6. HCMV interferes with the MHC class I peptide loading complex by
inhibiting tapasin expression
*Anne Halenius, Sebastian Hauka , Frank Momburg, Hartmut Hengel
7. Rapid reconstitution of T cell memory and remission of EBV
lymphomas after therapeutic transfer of EBV-specific T cells
*Andreas Moosmann, Iris Bigalke, Stefanie Tippmer, Julitta Urlacher,
Wolfgang Hammerschmidt, Hans-Jochem Kolb
*: Presenting author
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Workshops
Workshop: Pathogenesis and persistence I
Chairs: Jan Münch (Ulm)
Norbert Tautz (Gießen)
When & Where: Friday, March 7th, 2008
15:45 – 17:30
XLIV
Zool. – Großer Saal
1. Processing of genome 5’ termini as a strategy of negative-strand
RNA viruses to avoid RIG-I-dependent interferon induction
*Matthias Habjan, Ida Andersson, Jonas Klingström, Michael
Schümann, Arnold Martin, Petra Zimmermann, Valentina Wagner,
Andreas Pichlmair, Urs Schneider, Elke Mühlberger, Ali Mirazimi,
Friedemann Weber
2. Correlation between cofactor dependency and pestiviral
persistence
*Deborah Basso, Heinz-Jürgen Thiel, Norbert Tautz
3. Identification and characterisation of MCMV encoded miRNAs in
vitro and in vivo
*Lars Dölken, Zsolt Ruzsics, Jonathan Perot, Soutschek Jürgen,
Matthias John, Sébastien Pfeffer, Ulrich H. Koszinowski
4. The murine cytomegalovirus m38.5 protein inhibits Bax-mediated
cell death
*Uwe Schumacher, Igor Jurak, Hrvoje Simic, Sebastian Voigt, Wolfram
Brune
5. Transactivation of cellular genes by the regulatory IE1 protein of
murine cytomegalovirus
*Vanessa Wilhelmi, Christian O. Simon, Verena Böhm, Silke A.
Oehrlein-Karpi, Angelique Renzaho, Matthias J. Reddehase, Natascha
K. A. Grzimek
6. The Epstein-Barr virus-encoded protein BDLF2 is influencing the
actin cytoskeleton resulting in enlarged cell surface and increased
motility
Jens Bernhard Lösing, Klaus Ritter, *Michael Kleines
7. Interferon-gamma influences the pathogenesis after H5N1 influenza
A virus infection in mice
*Emanuel Haasbach, Sarah Reiling, Mathias Buettner, Oliver Planz
*: Presenting author
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Workshops
Workshop: Virus structure, assembly and egress II
Chairs: Kay Grünewald (München)
Barbara Klupp (Insel Riems)
When & Where: Saturday, March 8th, 2008
09:15 – 11:00
1. The role of actin in polarized release of measles virus
*Erik Dietzel, Nicole Runkler, Andrea Maisner
XLV
CH – Großer Saal
2. Studying association of influenza virus HA with membrane-rafts
using fluorescence-resonance-energy transfer (FRET)
*Stephanie Engel, Nils Krebs, Silvia Scolari, Claudia Tielesch, Andreas
Herrmann, Michael Veit
3. Late domains of the Marburg virus nucleoprotein and their role in
Marburg virus-like particle release.
*Olga Dolnik, Florian Zielecki, Lea Stevermann, Larissa Kolesnikova,
Stephan Becker
4. Cryo-Electron Microscopy Reveals that Vaccinia Virus Precursor
Consists of Single Membrane and Scaffold Protein
*Petr Chlanda, Alejandra Carbajal, Gareth Griffiths, Marek Cyrklaff,
Jacomine Krijnse-Locker
5. HIV-1 transframe protein p6*, a spacer protein dispensable for viral
in vitro replication
*Andreas Leiherer, Christine Ludwig, Ralf Wagner
6. Structural and stoichiometrical Studies on Ribonucleoprotein
Complex Components of Borna Disease Virus
Ina Kraus, Guy Schoehn, Marc Jamin, Wolfgang Garten, Winfried
Weissenhorn, *Miriam Hock
7. Essential role of domain III of non-structural protein 5A for
Hepatitis C virus infectious particle assembly
*Margarita Zayas, Nicole Appel, Sven Miller, Jacomine Krijnse-Locker,
Torsten Schaller, Peter Friebe, Stephanie Kallis, Ulrike Engel, Ralf
Bartenschlager
*: Presenting author
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Workshops
Workshop: Pathogenesis and persistence II
Chairs: Jan Münch (Ulm)
Norbert Tautz (Gießen)
When & Where: Saturday, March 8th, 2008
09:15-11:00
1. The role of annexin A2 in the hepatitis C virus life cycle and
potential implications for pathogenesis
*Perdita Backes, Simon Reiss, Doris Quinkert, Thomas Longerich,
Volker Gerke, Ralf Bartenschlager, Volker Lohmann
XLVI
Zool. – Großer Saal
2. Limitation of hepatitis C virus (HCV) escape from a dominant HLA-
B27 restricted CD8+ T-cell epitope by replication fitness
*Eva Dazert, Christoph Neumann-Haefelin, Nicole Appel, Susan
McKiernan, Dermot Kelleher, Robert Thimme, Ralf Bartenschlager
3. Mouse Hepatitis Virus liver pathology is dependent on ADP-ribose
1''-phosphatase, a viral function conserved in the alpha-like
supergroup
Klara Kristin Eriksson, Luisa Cervantes-Barragán, Burkhard Ludewig,
*Volker Thiel
4. Exploring new mechanisms of antiviral activity of APOBEC3C
*Henning Hofmann, Klaus Cichutek, Carsten Münk
5. Evaluation of a HIV integrase inhibitor in the transgenic rat model
of HIV infection
*Christine Goffinet, Ina Allespach, Lena Oberbremer, Pamela Golden,
Scott Foster, Johns Brian, Weatherhead Jason, Novick Steven, Chiswell
Karen, Garvey Edward, Keppler Oliver T.
6. Inhibition of Transferrin-Receptor Uptake by SIV and HIV Nefalleles
*Swantje Gundlach, Carina Banning, Alicja Iwanski, Frank Kirchhoff,
Michael Schindler
7. Determinants of the HIV pathogenesis factor Nef for efficient virus
replication and CD4 T lymphocyte depletion in ex vivo human tonsil
histocultures
*Homann Stefanie, Tibroni Nadine, Baumann Ingo, Sertel Serkan,
Keppler Oliver T. , Oliver T. Fackler
*: Presenting author
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Workshops
Workshop: Viral RNA genome replication
Chairs: Elke Mühlberger (Marburg)
Volker Thiel (St. Gallen)
When & Where: Saturday, March 8th, 2008
09:15 – 11:00
1. RNA replication of Tomato bushy stunt virus in a plant-derived in
vitro system
*Torsten Gursinsky, Beate Schulz, Sven-Erik Behrens
XLVII
CH – Kleiner Saal
2. Genome Organization and Reverse Genetic Analysis of a Type I
Feline Coronavirus
*Gergely Tekes, Regina Hofmann-Lehmann, Iris Stallkamp, Volker Thiel,
Heinz-Jürgen Thiel
3. Structural and functional characterization of the chymotrypsin-like
protease of the human pathogenic sapovirus
Ivonne Robel, Julia Gebhardt, Jeroen Mesters, Alexander Gorbalenya,
Bruno Coutard, Bruno Canard, Rolf Hilgenfeld, *Jacques Rohayem
4. Localization determines function: N-terminally truncated NS5A
fragments accumulate in the nucleus and impair HCV replication
*Daniel Sauter, Kyoshi Himmelsbach, Malte Kriegs, Eberhard Hildt
5. Novel function of the influenza A virus PB1-F2 protein – Regulation
of viral polymerase activity by interaction with the PB1 polymerase
subunit
Igor Mazur, Darisuren Anhlan, David Mitzner, Ludmilla Wixler, Ulrich
Schubert, *Stephan Ludwig
6. Characterization of the Ebola virus VP30 – NP interaction
*Nadine Biedenkopf, Bettina Hartlieb, Stephan Becker
7. Foamy virus protein Bet alters biochemical properties of APOBEC3
proteins
*Mario Perkovic, Benjamin Stauch, Henning Hofmann, Stanislaw
Schmidt, Ferdinand Kopietz, Gisbert Schneider, Martin Löchelt, Klaus
Cichutek, Carsten Münk
*: Presenting author
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XLVIII

Abstract overview
Abb. Workshop Page
VEN Virus entry 1
VDR Viral DNA genome replication 27
SAE Virus structure, assembly and egress 34
TTL Transcription and translation 99
VRR Viral RNA genome replication 121
IIR Innate immune response 146
ATR Antiviral therapy and resistance 193
VGT Viral vectors and gene therapy 228
AIV Adaptive immune response and vaccination 260
STD Signal transduction 321
CLV Clinical virology 341
IDM Innovative diagnostic methods 373
PPT Pathogenesis and persistence 391
TOG Transformation and oncogenesis 438
EZO Epidemiology and zoonoses 460
SBV Systems biology of viral infections 495
HCF Host cell factors 502
*: Presenting author °:Corresponding author
XLIX