Critical Care

intensive care unit; IQR, interquartile range; OR, odds ratio; PROTECT, Prophylaxis for
ThromboEmbolism in Critical Care Trial; SD, standard deviation.
Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
DC, EM, FC, and NZ conceived of the study. DC, EM, FC, NZ, IW, TM, AM, FC, and MCF
designed the study. NZ and SV coordinated the study. DC obtained funding. EM, OS, NZ, IW,
TM, AM, FC, SV and MCF collected data. DC, RF, NA, JM and MM consulted on methods.
DHA performed the analyses. YA, NA, RF and DC designed the figure. DHA, DC, SF, TC, RF,
YA, CW, NO, RH, NA, JM and MM interpreted the data. DC, EM, OS, DHA and MM wrote the
draft. All authors read and approved the final manuscript for publication.
Acknowledgements
This study was funded by a North American Meeting Grant of the Canadian Institutes for Health
Research which had no role in the design, conduct, analysis, interpretation or write up of this
report. D Cook, N Zytaruk and D Heels-Ansdell had full access to all the data in the study and
take responsibility for the integrity of the data and the accuracy of the data analysis.
We appreciate the interest of family members and patients in research, which enabled
the main trial and this study. We thank research coordinators and physicians from all