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Figure 1. Factorial and coenrolment designs. In this figure, we present a schematic for a
factorial design randomized trial, sequential coenrolment in 2 randomized trials and
simultaneous coenrolment in 2 randomized trials.
Figure 2. Coenrolment Schema. In this figure, we outline steps taken to consider coenrolment
of 1 patient into 1 or more additional studies. ABLE Trial, Age of Blood Evaluation Trial;
ANZICS, Australian and New Zealand Intensive Care Society Clinical Trials Group; CCCTG,
Canadian Critical Care Trials Group; Fonda, fondaparinux; REB, Research Ethics Board; UFH,
unfractionated heparin.