Sorachai Srisuma MD PhD Sorachai Srisuma MD PhD ssrisuma@rics.bwh.harvard.edu

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Hypertonic saline-induced sputum Is used to evaluate airway inflammation in the central airway. Can be used to study cellular components from the mucus. Soluble remodeling-associated proteins, such as procollagen synthesis peptides, MMP, TIMP and cytokines, can be detected in the sputum supernatants.
Is a noninvasive method and reflects the composition of the fluid lining the airway. Several markers including hydrogen peroxide, leukotrienes, prostaglandins, isoprostanes, nitro oxide-derived products and hydrogen ions have been measured successfully in EBC.
Page 1: Sorachai Srisuma MD PhD Sorachai Sr
Page 6 and 7: Epithelial Basement Subepithelial a
Page 8 and 9: Resected tissue needs to be preserv
Page 11 and 12: Bronchiole -H&E staining
Page 14 and 15: Hypoxia of airway epithelial cells
Page 16 and 17: SERPINE2 (PN1) localization in mous
Page 18 and 19: It allows detection of specific mRN
Page 20: Is performed under flexible broncho
Page 23: Stained BAL cells
Page 27 and 28: Indirect monitoring of lung inflamm
Page 30 and 31: Protein quantification in fluids us
Page 32 and 33: FEV 1 , FEC, FEV 1 /FVC ◦ Post-br
Page 34 and 35: Airway Hyperreactivity or Airway hy
Page 36 and 37: Plethysmograph is derived from the
Page 38 and 39: The subject makes respiratory effor
Page 40 and 41: Flow signal is positive during expi
Page 42 and 43: At constant temperature, P1V1 = P2V
Page 44 and 45: Body plethysmography is particularl
Page 46 and 47: When normal human expires fully to
Page 48 and 49: Single breath N 2 washout test p.50
Page 50 and 51: When, as a result of dynamic compre

Sorachai Srisuma MD PhD Sorachai Srisuma MD PhD ssrisuma@rics.bwh.harvard.edu

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