La néoangiogenèse tumorale
VEGF - FMC de Tours
VEGF - FMC de Tours
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Cul 2<br />
Elo Elo<br />
B C<br />
α<br />
β<br />
pVHL<br />
Rbx1<br />
E2<br />
OH OH<br />
Pro Asn<br />
Ub<br />
HIF-α<br />
elongin B (Elo B)<br />
elongin C (Elo C)<br />
Ring-box 1 (Rbx1 ou ROC1 or Hrt1)<br />
Cullin 2 (Cul 2)<br />
Cul 2<br />
Elo Elo<br />
B C<br />
pVHL<br />
Rbx1<br />
E2<br />
OH OH<br />
Pro Asn<br />
HIF-α<br />
Complexe VHL<br />
OH OH<br />
Pro Pro<br />
HIF-α<br />
asn<br />
OH<br />
Protéasome<br />
polyubiquitination<br />
P300/CBP<br />
Maladie de VHL<br />
OH<br />
OH Pro<br />
HIF-α<br />
HIF-β<br />
P300/CBP<br />
Angiogenèse<br />
Tumorigenèse
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