MISSION

FAMRI Supported Publications
Albers A, Abe K, Hunt J, Wang J, Lopez-Albaitero A, Schaefer C, Gooding W, Whiteside TL, Ferrone S,
DeLeo A, Ferris RL. Antitumor activity of human papillomavirus type 16 E7-specific T cells against
virally infected squamous cell carcinoma of the head and neck. Cancer Res 2005;65:11146-11155.
Albers AE, Ferris RL, Kim GG, Chikamatsu K, DeLeo AB, Whiteside TL. Immune responses to p53 in
patients with cancer: enrichment in tetramer+ p53 peptide-specific T cells and regulatory CD4+CD25+
T cells at tumor sites. Cancer Immunol Immunother 2005;54:1072-1081.
Kim J, Ferris RL, Whiteside TL. CCR7 protects T lymphocytes from apoptotic cell death in patients with
head and neck cancer. Clin Cancer Res 2005;11:7901-7910.
Kuss I, Hathaway B, Ferris RL, Gooding W, Whiteside TL. Decreased absolute counts of T lymphocyte
subsets and their relation to disease in squamous cell carcinoma of the head and neck. Clin Can Res
2004;10:3755-3762.
Kuss I, Schaefer C, Godfrey TE, Ferris RL, Harris JM, Gooding W, Whiteside TL. Recent thymic
emigrants and subsets of naive and memory T cells in the circulation of patients with head and neck
cancer. Clin Immunol 2005;116:27-36.
Lopez-Albaitero A, Nayak JV, Ogino T, Machandia A, Gooding W, DeLeo AB, Ferrone S, Ferris RL. Role
of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and
neck cells to recognition by CTL. J Immunol 2006;176:3402-3409.
Sirianni NM, Ha PK, Oelke M, Califano J, Gooding W, Westra W, Whiteside TL, Koch WM, Schneck JP,
DeLeo A, Ferris RL. Effect of human papillomavirus-16 infection on CD8+ T cell recognition of a wild
type sequence p53264-272 peptide in head and neck cancer patients. Clin Can Res 2004;10:6929-
6937.
PKC-EPSILON EXPRESSION ON THE OUTCOME OF CHEMOTHERAPY
Lei Xiao, PhD; University of Florida; CIA 2002
Dr. Xiao investigated the relationship between expression of a protein kinase C (PKC)-epsilon isoform
and patient response to lung cancer chemotherapy. The difference in the regulation of PKC-epsilon expression
may be important with respect to the cellular response to lung cancer chemotherapy. Results suggest
that PKC-epsilon-negative lung cancer patients may have a better prognosis.
ADENOVIRAL GENE TRANSFER OF FRNK AND P53 FOR TREATMENT OF HEAD AND NECK CANCER: IN VITRO
STUDIES
Lori J. Kornberg, PhD; University of Florida; CIA 2003
Dr. Kornberg has shown that focal adhesion kinase (FAK), a tyrosine kinase that mediates intracellular
signals produced by the integrin family of adhesion receptors, is overexpressed in oral and laryngeal cancers.
The PI produced an epithelial line that overexpresses FAK-related non-kinase (FRNK), an FAK
inhibitor, for study of these cancers. Her data suggest that expression of p53 and FRNK render cancer cells
exquisitely sensitive to anticancer drugs.
FAMRI Supported Publications
Kornberg LJ, Villaret D, Popp M, Lu L, McLaren R, Brown H, Cohen D, Yun J, McFadden M. Gene
expression profiling in squamous cell carcinoma of the oral cavity shows abnormalities in several signaling
pathways. Laryngoscope 2005;115:690-698.
Kornberg LJ. Adenovirus-mediated transfer of FRNK augments drug-induced cytotoxicity in cultured
SCCHN cells. Anticancer Res 2005;25:4349-4356.
ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND ITS DOWNSTREAM TARGETS IN HEAD AND
NECK CANCERS OF SMOKING PATIENTS
Alexey Fomenkov, PhD; The Johns Hopkins University; CIA 2003
Dr. Fomenkov found that HNSCC from patients affected by both primary smoking and second-hand
smoke exposure displayed induced tyrosine autophosphorylation of the epithelial growth factor receptor
(EGFR) tyrosine and activated the phosphoinositol 3- kinase/protein kinase B (P3IK/Akt) signaling pathway.
Profiling analysis of genes induced and downregulated in human tumor samples of primary smokers
and those exposed to second hand tobacco revealed that the p63 gene was dramatically induced. Dr.
Fomenkov showed that p63, which is a transcriptional regulator of epithelial stratification, is one of the
major downstream targets of EGFR and its expression is specifically modulated by the PI3K/Akt pathway
rather than by Ras/ErkIMAPK pathway. The expression pattern of ANp63a, which is a major p63 isotype
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