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CONTENTS <strong>MISSION</strong> ..............................................................................................................................................................................................1 DEDICATION .......................................................................................................................................................................................2 FOREWORD David Sidransky, MD; Vice-Chairman, FAMRI’s Medical Advisory Board, The Johns Hopkins University 3 CONTENTS ...........................................................................................................................................................................................4 INTRODUCTION..............................................................................................................................................................................12 FAMRI ORGANIZATIONAL STRUCTURE ......................................................................................................................13 FAMRI AWARD CATEGORIES...............................................................................................................................................14 Peer Reviewed Awards ......................................................................................................................................................14 Center Of Excellence Award ........................................................................................................................................14 The Clinical Innovator Award Program ......................................................................................................................14 The Young Clinical Scientist Award Program............................................................................................................14 Board Designated Awards .................................................................................................................................................14 The William Cahan Distinguished Professor Award Program................................................................................14 The Bland Lane InteRNational Distinguished Professor Award Program............................................................14 Other Board Designated Awards.................................................................................................................................14 GEOGRAPHIC DISTRIBUTION .............................................................................................................................................15 International..........................................................................................................................................................................15 United States.........................................................................................................................................................................15 HIGHLIGHTED RESEARCH......................................................................................................................................................16 Second Hand Tobacco Smoke And Cardiovascular Dysfunction In Children..........................................................16 Judith Groner, MD and John A. Bauer, PhD; Ohio State University; CIA 2006 ....................................................16 Research And Education On Smoke-Free Air For Pets And Families........................................................................17 Ronald M. Davis, MD (Sharon A. Milberger, ScD); Henry Ford Health System; CIA 2006.................................17 Effect Of Second Hand Tobacco Smoke On Respiratory And Reproductive Tract Epithelial Cell Production And Release Of Ccl20 ..........................................................................................................................................................17 Mardi Crane-Godreau, PhD; Dartmouth College; YCSA 2006 .................................................................................17 Role Of SHS On Somatic Alterations In Bladder Cancer .............................................................................................18 Carmen J. Marsit, PhD; Brown University;YCSA 2006 .............................................................................................18 Usurping Signaling Characteristics Of Breast, Cervical, And Prostate Cancer To Target Them With A ‘Signal-Smart’ Virus ..................................................................................................................19 Faris Farassati, PhD, PharMD; University of Kansas; YCSA 2006 ..........................................................................19 Elastin Degradation In Pulmonary Diseases ..................................................................................................................20 Yong Y. Lin, PhD and Gerald Turino, MD; St. Luke’s-Roosevelt Hospital Center; BDA 2005 ..............................20 Second Hand Tobacco Smoke And Worker Health.......................................................................................................21 David J. Lee, PhD; University of Miami; CIA 2002, 2003, 2006, 2009.......................................................................21 Rage-Mediated Effects Of Pulmonary Inflammation And Emphysema......................................................................22 Paul R. Reynolds, PhD; University of Utah; YCSA 2007 ............................................................................................22 Functional Characterization Of Sccro..............................................................................................................................22 Bhuvanesh Singh, MD, FAC; Memorial Sloan-Kettering Cancer Center; CIA 2006 ............................................22 Amelioration Of Allergic Rhinitis By Multi-Functional Anti-Inflammatory Drugs: Results Of A Phase Ii Clinical Study ................................................................................................................................23 Saul Yedgar, PhD; Hebrew University of Jerusalem; BDA 2008.............................................................................23 Household Smoking Bans: A Comprehensive Analysis ...............................................................................................23 Nancy Rigotti, MD; Massachusetts General Hospital; CIA 2006, 2009..................................................................23
FAMRI CENTERS OF EXCELLENCE...................................................................................................................................25 FAMRI-BLAND LANE CENTER OF EXCELLENCE ON SECOND HAND SMOKE AT UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, 2002, RENEWED 2007 ...............................................................................25 Director: Neal L. Benowitz, MD..........................................................................................................................................25 Tobacco Gene-Environment Interactions In African American And Latino Asthmatics........................................27 Esteban Gonzalez-Burchard, MD, MPH .....................................................................................................................27 Acute Effects Of Second Hand Tobacco Smoke Exposure In The Upper And Lower Respiratory Tract ............27 John Balmes, MD ...........................................................................................................................................................27 The Impact Of SHS Exposure On Pulmonary Function, Disability, And Cardiovascular Disease........................28 Mark Eisner, MD, MPH..................................................................................................................................................28 Second Hand Tobacco Exposure Assessment Core......................................................................................................28 Neal L. Benowitz, MD ....................................................................................................................................................28 Flight Attendant Medical Research Clinical Practice..................................................................................................29 Rita Redberg, MD............................................................................................................................................................29 Chronic Effects Of Second Hand Tobacco Smoke Exposure On Lung Function Of Flight Attendants.................29 Warren M. Gold, MD ......................................................................................................................................................29 Economic Burden Of Second Hand Tobacco Smoke ....................................................................................................29 Wendy Max, PhD ............................................................................................................................................................29 Implementing The Evidence...............................................................................................................................................30 Lisa A. Bero, PhD............................................................................................................................................................30 FAMRI CENTER OF EXCELLENCE AT THE WEIZMANN INSTITUTE OF SCIENCE, 2004, RENEWED 2009.........................30 Director: Varda Rotter, PhD.................................................................................................................................................30 The Pro-Apoptotic Dap-Kinase Gene: Molecular Basis Of Its Tumor Suppressive Functions And Implications In Lung Cancer Diagnosis/Prognosis/Therapy ...............................................................................................................30 Adi Kimchi, PhD...............................................................................................................................................................30 Correlation Of DNA Polymorphisms And Large-Scale Gene Expression With Susceptibility To Evolution And Progression To Tobacco Smoke-Related Lung Cancer.................................................................................................32 Gideon Rechavi, MD, PhD.............................................................................................................................................32 In Vitro Model For Tumor Progression Of Lung-Derived Cell: Biological And Molecular Characterization And Functional Analysis Of P53 Gene Alterations.................................................................................................................33 Moshe Oren, PhD............................................................................................................................................................33 Reduced Repair Of The Oxidative Dna Lesion 8-Oxyguanine As A Risk Factor In Lung Cancer.........................34 Zvi Livneh, PhD................................................................................................................................................................34 FAMRI CENTER OF EXCELLENCE AT THE SIDNEY KIMMEL COMPREHENSIVE CANCER CENTER, THE THE JOHNS HOPKINS UNIVERSITY, 2005............................................................................................................................35 Director: Charles M. Rudin, MD, PhD ...............................................................................................................................35 Administrative Core .............................................................................................................................................................36 Charles M. Rudin, MD, PhD ..........................................................................................................................................36 Clinical Core..........................................................................................................................................................................36 Charles M. Rudin, MD, PhD ..........................................................................................................................................36 Drug Discovery Core............................................................................................................................................................37 Phillip Cole, MD, PhD .....................................................................................................................................................37 Synthetic Chemistry Core Component Of The Drug Discovery Core..........................................................................37 David Meyers, PhD.........................................................................................................................................................37 Clinical Compound Screening Initiative Core Component Of The Drug Discovery Core.......................................37 Jun Liu, PhD.....................................................................................................................................................................37 Drug Screening Core ...........................................................................................................................................................38 Rhoda Alani, MD .............................................................................................................................................................38 Pharmacokinetic Core.........................................................................................................................................................38 Michelle A. Rudek, PhD, Pharm D ...............................................................................................................................38 Angiogenesis Core...............................................................................................................................................................38 Rhoda Alani, MD .............................................................................................................................................................38 Translation Of Evidence Core ............................................................................................................................................39 David Holtgrave, PhD .....................................................................................................................................................39 Developmental Project 1: Prodrug Strategies For Lung Cancer .................................................................................39 Caren Meyers, PhD ........................................................................................................................................................39
Page 3 and 4: MISSION FAMRI is an Independent Not
Page 5: FOREWORD David Sidransky, MD, Vice-
Page 9 and 10: PAI-1 And Airway Remodeling In Seco
Page 11 and 12: Promoter Hypermethylation As A Mole
Page 13 and 14: Expression Profiling Of Blood In Lu
Page 15 and 16: Inhibition Of Hedgehog Signaling By
Page 17 and 18: Genetic Epidemiology Of Pulmonary F
Page 19 and 20: Reducing Second Hand Tobacco Smoke
Page 21 and 22: SINUSITIS .........................
Page 24 and 25: INTRODUCTION David M. Burns, MD, Pr
Page 26 and 27: FAMRI AWARD CATEGORIES The Board of
Page 28 and 29: HIGHLIGHTED FAMRI FUNDED RESEARCH C
Page 30 and 31: Xia L, Crane-Godreau M, Deng B, Lei
Page 32 and 33: Farassati F, Yang A-D, Lee P WK. On
Page 34 and 35: Nicotine & Tobacco Research 2007;9:
Page 36 and 37: homes where smoking is banned are m
Page 38 and 39: a survey-based COPD severity score.
Page 40 and 41: allergic rhinitis have increased re
Page 42 and 43: However, while the economic costs a
Page 44 and 45: mitochondrial adenosine diphosphate
Page 46 and 47: CHR, and CDE. The promoter architec
Page 48 and 49: Trends Mol Medicine 2007;13:150-157
Page 50 and 51: was also demonstrated to be effecti
Page 52 and 53: and are currently in clinical testi
Page 54 and 55: Academic Societies’ Meeting. Hono
Page 56 and 57:
acceptability, and usefulness of us
Page 58 and 59:
utilize telephone conference call f
Page 60 and 61:
FAMRI-FUNDED RESEARCH COMBATING EFF
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act via limited proteolysis of subs
Page 64 and 65:
was significantly higher in Nic:RSV
Page 66 and 67:
presenting cells (APC) in vitro; an
Page 68 and 69:
FAMRI Supported Publications Collac
Page 70 and 71:
nisms of combostatin and its parent
Page 72 and 73:
Bladder cancer progression involves
Page 74 and 75:
45, NPV = 8%), 3 months (n = 42, NP
Page 76 and 77:
THE EFFECT OF ADENYLATE KINASE 3 ON
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Agency report in 2006 (ftp://ftp.ar
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Narayan S, Jaiswal AS. Structure-ba
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in the duration of the cigarette sm
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ENVIRONMENTAL AND GENETIC RISK FACT
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Estrogen activates the cell cycle b
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Schaeffer MW, Sinha Roy S, Mukherje
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east tumors. When breast cancer cel
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is to identify and characterize key
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of these target genes are regulated
Page 96 and 97:
CANCER, GASTRIC CURRENT RESEARCH GA
Page 98 and 99:
CANCER, HEAD AND NECK CURRENT RESEA
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Tran HM, Shi G, Li G, Carney JP, O
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ANALYSIS OF SERUM PEPTIDES ASSOCIAT
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(BE), gastroesophageal reflux disea
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CANCER, HEAD AND NECK COMPLETED RES
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in normal epithelia, was shown to b
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Commentary: Bonn, D. Urine test for
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disease (COPD), innate immune dysfu
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SCLC. The foundation for this appro
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Witta SE, Gemmill RM, Hirsch FR, Co
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MYC-induced lymphomagenesis. It wil
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PUMA Mediates Intestinal Apoptosis
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leomycin-induced pulmonary fibrosis
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dimensional magnetic resonance micr
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vaccine, Ad.p53-DC, was well tolera
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esults of these studies should also
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prostaglandin E2 in non-small-cell
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were sequenced from NSCLC tissue an
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expression has a protective effect
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evaluate the expression level of Id
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as a target for the sensitization o
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Cancer Biol Ther 2006;5(1):48-53. A
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REGULATION OF TGF BETA SIGNALING IN
Page 144 and 145:
among men exposed to cigarette smok
Page 146 and 147:
FAMRI Supported Publications Gibbs
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or 500 ppm CO for 30 days. Blood pr
Page 150 and 151:
adiponectin signals through activat
Page 152 and 153:
CARDIOVASCULAR COMPLETED RESEARCH S
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EFFECTS OF SECOND HAND TOBACCO SMOK
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nicotine administration in vivo on
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degradation of type III collagen in
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wild-type (WT) mice and mice geneti
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REDUCED NEUTROPHIL DEATH IN TOBACCO
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H 2 O 2 -induced nuclear fragmentat
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The aims of this study are: 1) to d
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tion (GWA) studies of quantitative
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propagation of emphysema by alveola
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duced mainly by alveolar type-II ep
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concentrations of inflammatory indi
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subglottis. Arch Otolaryngol Head N
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detector row CT (MDCT), 2005. Prese
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of smoke-free homes: findings from
Page 182 and 183:
Travers MJ, Hyland A. Wisconsin Air
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understood there would be several v
Page 186 and 187:
Travers MJ, Cummings KM, Repace JL,
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REDUCING SHS: CARDIAC AND ASTHMA OU
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tobacco companies fought tobacco co
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consumer acceptance through Web-bas
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housing, there is a need for scient
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youth to magazine tobacco advertisi
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Stukel JM, Heys JJ, Caplan MR. Opti
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EXPOSURE TO SECOND HAND TOBACCO SMO
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aldosterone, cortisol, corticostero
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the expression of numerous genes th
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and signaling functions), is suppre
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development and behavior, from the
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dams exposed to 75 ppm (1 pack/day)
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Poster Presentation at the 11th Int
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inhibition among Blacks and Whites.
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tobacco exposure (biologic measures
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ularly true for the chemokine GRO-a
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EPITHELIUM AND IMMUNOMODULATION IN
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patency was best assessed using hig
Page 224 and 225:
significant increases in sinusitis
Page 226 and 227:
VISION ONGOING RESEARCH GENE PROFIL
Page 228 and 229:
FAMRI DISTINGUISHED PROFESSORS FAMR
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is a strong motivator for smoking c
Page 232 and 233:
egulations and attitudes towards th
Page 234 and 235:
y the tobacco industry of the harmf
Page 236 and 237:
epair capacity assays. Her collabor
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Society for Research on Nicotine an
Page 240 and 241:
PERSONAL THOUGHTS FROM THE FLIGHT A
Page 242 and 243:
APPENDICES: LIST OF FAMRI GRANTEES
Page 244 and 245:
BDA Butter, Karen A., MLS Universit
Page 246 and 247:
AWARD INVESTIGATOR INSTITUTION TITL
Page 248 and 249:
Page 250 and 251:
Page 252 and 253:
Page 254 and 255:
APPENDICES: ACRONYMS The following
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apoptosis. COPD. c2008;5:153-162. A
Page 258 and 259:
KW, Lengauer C. Identification of c
Page 260 and 261:
Brait M, Begum S, Carvalho AL, Dasg
Page 262 and 263:
Measuring disease-specific quality
Page 264 and 265:
Mukherjee M, Schuldenfrei A, Kowals
Page 266 and 267:
sion attenuates cigarette smoke- or
Page 268 and 269:
Kuck J, Bauer JA. Racial difference
Page 270 and 271:
2008;26:856-862. Helfrich BA, Raben
Page 272 and 273:
acute nephritis. Am J Nephrol 2008
Page 274 and 275:
O’Malley BW. Double DNA repair hi
Page 276 and 277:
of base excision repair pathways. C
Page 278 and 279:
virotherapy of anaplastic thyroid c
Page 280 and 281:
Marsit CJ, Posner MR, McClean MD, K
Page 282 and 283:
2008. Mukhopadhyay S, Mukherjee S,
Page 284 and 285:
Pache JC, Burton DW, Deftos LJ, Has
Page 286 and 287:
2004;114:1248-1259. Rangasamy T, Gu
Page 288 and 289:
Childhood pregnancy (10-14 years ol
Page 290 and 291:
J Public Health 2004;94:1959-1964.
Page 292 and 293:
2007;67(11):5337-5344. Sullivan AK,
Page 294 and 295:
2005;90:5265-5269. Vassallo R, Kroe
Page 296 and 297:
Fong Y. Effective treatment of head
Page 298 and 299:
apoptosis control. Biochem Biophys
Page 300 and 301:
APPENDICES: INDEX BY AUTHOR Abdulla
Page 302 and 303:
Palmer, James N 235 Pan, Quintin 23
Page 304 and 305:
NOTES: 2 9 2 P A G E
Page 306:
ATTRIBUTION FLIGHT ATTENDANT MEDICA
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