Comparative Study on the Function of Genome Regula
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<str<strong>on</strong>g>Comparative</str<strong>on</strong>g> <str<strong>on</strong>g>Study</str<strong>on</strong>g> <strong>on</strong> <strong>the</strong> Functi<strong>on</strong> <strong>of</strong> <strong>Genome</strong> <strong>Regula</strong>ti<strong>on</strong> by<br />
Epigenomics Method<br />
Tags: genome, institute, Illinois,<br />
Human genome sequencing has produced a large number <strong>of</strong> genetic informati<strong>on</strong>, but <strong>the</strong><br />
understanding <strong>of</strong> <strong>the</strong> functi<strong>on</strong> <strong>of</strong> each gene has not been achieved. In a new study, researchers at<br />
<strong>the</strong> University <strong>of</strong> Illinois reported that a new method called "comparative epigenomics" was used<br />
to identify genes functi<strong>on</strong>. The results <strong>of</strong> <strong>the</strong> study were published in <strong>the</strong> journal Cell <strong>on</strong> June 8,<br />
2012.<br />
"<str<strong>on</strong>g>Comparative</str<strong>on</strong>g> genomics is a comparis<strong>on</strong> between DNA and hist<strong>on</strong>e modificati<strong>on</strong>s," said a<br />
researcher at <strong>the</strong> Institute <strong>of</strong> biological engineering and genomics at <strong>the</strong> Illinois University."<br />
Although <strong>the</strong> genome <strong>of</strong> an organism c<strong>on</strong>tains all its genes, it is in fact determined by genes<br />
expressed in <strong>the</strong> genome. Although it has l<strong>on</strong>g focused <strong>on</strong> comparative genomics — <strong>the</strong><br />
comparis<strong>on</strong> <strong>of</strong> <strong>the</strong> genome in similar species, <strong>the</strong> comparative epigenomics provides a more<br />
in-depth understanding <strong>of</strong> <strong>the</strong> regulati<strong>on</strong> functi<strong>on</strong>.<br />
Researchers from University <strong>of</strong> Washingt<strong>on</strong>, Harris Lewin and Franklin West Harris from <strong>the</strong><br />
University <strong>of</strong> Georgia c<strong>on</strong>ducted research. They focused <strong>on</strong> three species: human, mouse and pig.<br />
By analyzing <strong>the</strong> 9 epigenetic markers and pluripotent stem cell, <strong>the</strong>y were able to c<strong>on</strong>struct a<br />
table view genome map for each species.<br />
The research team c<strong>on</strong>cluded that as l<strong>on</strong>g as <strong>the</strong> appropriate analysis procedures were taken,<br />
people could be able to identify <strong>the</strong> species with a c<strong>on</strong>servative marker <strong>of</strong> <strong>the</strong> species. They <strong>the</strong>n<br />
c<strong>on</strong>firmed that <strong>the</strong> c<strong>on</strong>servative epigenetic markers could be effectively used to label <strong>the</strong><br />
genome and to elucidate <strong>the</strong> regulatory functi<strong>on</strong> <strong>of</strong> <strong>the</strong> genome.<br />
Many diseases, such as sickle cell anemia, thalassemia, cystic fibrosis are related to genetic<br />
informati<strong>on</strong>. Comm<strong>on</strong> diseases <strong>of</strong>ten have multiple causes, which are <strong>of</strong>ten caused by multiple<br />
genes and envir<strong>on</strong>mental factors.<br />
One <strong>of</strong> <strong>the</strong> most pressing issues for science is to understand <strong>the</strong> science <strong>of</strong> genomics, which<br />
reveals a promising alternative. "A comparative study <strong>of</strong> <strong>the</strong> c<strong>on</strong>cept <strong>of</strong> genomics allows us to<br />
find more clues about <strong>the</strong> evoluti<strong>on</strong> <strong>of</strong> our genome".