The History of Cell Morphology

In the 1970s and 1980s, cytogenetic techniques have become maturer and streaming phenotype
detection technology also comes into the clinical application. Morphology could meet the clinical
diagnosis (especially blood cancer) to assess prognosis and guide treatment. For example,
ph-positive ALL needs adjust the treatment plan. The process has highlighted the lack of
diagnostics demands, such as in-depth knowledge of atypical diagnosis for difficult cases and
further classification and pathological mechanisms of blood cancer.
In some other aspects, morphology couldn’t drive the development of clinical hematology, and
also occasionally sentences the wrong direction, without providing a better basis for judgment.
Since 1990s, new technology in cellular genetics, cellular immunology and molecular aspects of
cells has made considerable progress; many projects in clinical laboratories can provide better
diagnosis and prognosis as well as individualized molecular targeted therapy of information.
These new technologies can gradually replace cell morphology and then become the leader of
defining blood cancer (especially new diseases) and diagnosis of specific types, which is another
driving force for the rapid development of clinical hematology.
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