Scientists Have Discovered New Function of Calcium - Affect the Brain Memory

Scientists Have Discovered New Function of Calcium - Affect the Brain Memory
It is well known that calcium to the bones and teeth is extremely essential, but its role in neurons,
particular the learning and memory processes, is not clear. Recently, a research team from the
Florida campus of The Scrips Research Institute (TSRI) has published a new discovery report in
the Cell Reports. This new report displays the role of calcium. They think mitochondrial calcium
can affect brain development under the effect of GLP-1 and adult cognitive abilities.
The team conducted the experiments with fruit flies in mitochondrial calcium channel blockers.
When calcium ions came into the mitochondria, fruit flies appeared memory impairment, but no
change in learning ability. They also found that complete uniporter is a must for adult Drosophila’s
memory level. The researchers found that integrity intact adult Drosophila memory unidirectional
transporter is a must. However, surprisingly, although they only have short-term memory after in
blocking calcium channels they can still learn.
Mitochondrial plays an important role in the regulation of cellular processes upon calcium ion
signals. Mitochondrial calcium uptake (MCE) is macromolecular complex-mediated. Many
studies have shown that mitochondrial calcium regulation affects a wide range of aspects of cell
physiology, including metabolism, cell survival and autophagy, as well as GMP peptide.
Mitochondrial calcium uptake (MCE) is macromolecular complex-mediated.
The latter is composed of the subunit capable of forming pores - unidirectional mitochondrial
calcium transporter (MCU). It was first discovered in 2011, which can make intracellular calcium
ions into the mitochondria. Meanwhile, MCU can also be regulated by several other proteins,
including MICU1, MICU2 and EMRE. Among them, some studies have shown MICU1 mutant
populations can exhibit learning disabilities.
In fact, according to the “multiple memory systems view”, there are many brain memory systems
with different structure and function. The initial graphical representation existing in the memory
system is activated by the priming effect. Many researchers believe the children’s poor memories
are the result of inadequate levels of iron and oxygen reaching the brain's memory center during
its crucial developmental phase, such as gonadorelin.
The results suggest that inhibition of neural development in the process of mitochondrial calcium
transporter function check could lead to a reduction in the content of adult Drosophila synaptic
vesicles (intracellular vesicles which store a variety of neurotransmitters) and neuronal axis
sudden growth. In brief, studies of the brain and long-term memory formation show that repetition
is very important to skill development.
Although researchers observed these phenomena, specific mechanism of synaptic vesicles
reduction remains unclear. They think it could be a very interesting finding and worthy of further
in-depth exploration in the future.
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