APP1135277_Rice_Grant Proposal

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GRANT PROPOSAL – 2016 Centres of Research Application ID: 1135277 Excellence funding commencing 2017 CIA Surname: Rice enhance the capacity of the CRE. To further promote the development of future leaders, the CRE will provide five PhD top-up scholarships to exceptional RHD students with clear leadership potential. Building the Translational Pipeline: A strong, long-term multidisciplinary collaborative network has already been established between CRE CIs and AIs that spans multiple national and international organisation. This network provides opportunity for intellectual exchange and the enhancement of the interface between technological advances and patient care. For example, this CRE will establish a translational pipeline between technology and application intensive facilities (e.g. AIBN) and clinical practice. This will be achieved by the placement of research staff and students into clinical development environments (e.g. UQCCR) and their direct engagement with clinical practice in Australian and internationally. New technological achievement thus can be aligned with clinical and patient needs. Building National and International Collaborations: The CIs are well positioned to leverage their existing national and international collaboration to further advance the research and training objective of the CRE. In particular, UQ CIs have extremely productive collaborative clinical research and MD and PhD training programs with the Ochsner Health System in New Orleans (the largest provider of health care services in Louisiana). A similar partnership has been established with one of the largest private hospital networks in Chile through Clinica Davila, Santiago, Chile. Such partnerships provide opportunity to expand collaborative engagement between the members of the CRE and advancement of clinical and scientific enterprise. 5. Record of research and translation achievement – relative to opportunity The CRE comes complete with a built-in capacity to translate its developments and these will represent the lasting legacy of the endeavour. The CI and AI team members each have outstanding records acquired on an international stage, of translating their research into practice within the very field addressed by the CRE. Past successes demonstrate a capacity to navigate and inject value to the service chain of delivery within healthcare systems. These are summarized in the attached table: CI Rice Simmons RECORD OF TRANSLATION IN FIELD More than a decade of experience within the biotechnology sector (both private and public) in the development, evaluation and implementation of diagnostics tests. Conducted phase 2 and 3 biomarker trials to evaluate the clinical utility of an early detection, blood based diagnostic. Industry experience includes being co-founder of biotechnology company HealthLinx, (HTX, 2003), Executive Director (2006), General Manager Science and Operations (2007) and Chairman (2008-2013). This company listed on the ASX in 2006 as a diagnostic company that focuses on the development and delivery of in vitro diagnostics and multivariate index assays. Service as a member of Clinical and Scientific Advisory Committees of ASXlisted companies and as a member of the Technical and Regulatory Standing Committee of IVD Australia (2010-2012). Closely involved in the translation of clinical research findings into clinical practice, in particular through the redefinition of gestational diabetes (member of the WHO working group), establishment/redesign of pre-pregnancy and Page 18
GRANT PROPOSAL – 2016 Centres of Research Application ID: 1135277 Excellence funding commencing 2017 CIA Surname: Rice McIntyre Kumar Trau Mitchell pregnancy services in Australia, New Zealand and UK. Established diabetes peer support across an English county, taken up by Diabetes UK across a further 5 counties (type 2 together)-training and other components now embedded in diabetes UK operations Developed and evaluated diabetes integrated care approach now in place in in parts of Cambridgeshire Part of team that developed/introduced RCT of school based intervention to reduce childhood obesity in the Waikato, NZ-now continued and extended beyond Waikato Study of random blood glucose screening for GDM at booking - now used by many services around the world Regional study of a systems approach to pre-pregnancy planning in T1/T2 diabetes in a number of centres in East Anglia, now extended across more Hospitals Closely involved in the translation of clinical research findings into clinical practice, in particular through the redefinition of gestational diabetes and promotion of optimal diagnosis and treatment of this common pregnancy complication. Development of guidelines including most notably: Queensland Clinical Guidelines Translating evidence into best clinical practice GDM Local GDM implementation International (FIGO) guidelines Updating of guidelines in the light of new evidence Contributed to the most recent set of guidelines put out by the Fetal & Neonatal Transfusion sub-committee of the British Committee for Standards in Haematology (BCSH). Co-author of an RCOG guideline pertaining to the management of women with red cell antibodies in pregnancy. These guidelines influence and guide practice in many different countries. Specialist advice to the National Institute of Clinical Excellence for Fetal Medicine Interventional procedures and review of fetal medicine guidelines prior to publication Clinical advisor to the Healthcare Commission Developed nanoscale biosensors as a strategy for disease management Developed single drop DNA test with capacity to revolutionise the detection of diseases Initiated and led collaboration between leading nanotechnologists, molecular biologists, geneticists and commercial researchers with the goal of creating cutting edge diagnostics. Member Medicine and Public Health Panel (2012) for the Performance Based Research Fund that reviewed “quality” measures for all University Researchers in New Zealand (1,000). Reviewer for three Tommy’s research centres in the United Kingdom to determine their progress and whether the Campaign would continue funding them. Reviewer applications for the Preterm Labour Centre funded by Harris Wellbeing, UK Discovered true cause of Pre-term labour (Discovery in collaboration with Dr Roberto Romero) Page 19
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APP1135277_Rice_Grant Proposal

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