APP1135277_Rice_Grant Proposal

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GRANT PROPOSAL – 2016 Centres of Research Application ID: 1135277 Excellence funding commencing 2017 CIA Surname: Rice Community engagement and participation - Chairman, National Centre for Health Innovation Professional Involvement (selected) 2010-2012 Immediate Past President, International Federation of Placenta Associations 2007-2009 President, International Federation of Placenta Associations 2012-present Member, Editorial Board, Open Journal of Obstetrics and Gynecology 2012- present Member, Editorial Board, Conference Papers in Biology 2011-present Member, Editorial Board, Scientifica Supervision and Mentoring (last 5 year) Honours 8 (1 current); MSc 1(1); PhD 4 (3) Peer Recognition and Service last 5 year (selected): 2013 NHMRC Grant Review Committee 2012 NHMRC Research Translation Faculty 2012 NHMRC Grant Review Committee 2011 NHMRC Fellowship Review Committee Other contributions to NHMRC 2014 NHMRC Assigner Academy Top 5 Publication in the last 5 years 1. Sarker S, Scholz-Romero K, Perez ,. Illanes SE, Mitchell MD, Rice GE , Salomon C. Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. Journal of Translational Medicine. (2014) 12:204 doi:10.1186/1479-5876-12-204 2. Salomon C, Torres MJ, Kobayashi M, Scholz K, Sobrevia L, Sobrevia L, Dobierzewska A, Illanes SE, Mitchell MD, Rice GE (2014) Pregnancy-Associated Changes in Placenta- Derived Exosome Concentration and Bioactivity in Maternal Plasma. PLoS One. DOI: 10.1371/journal.pone.0098667 3. Kobayashi M, Salomon C, Tapia J, Illanes, SE, Mitchell MD, Rice GE (2014) Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200. Journal of Translational Medicine. 12:4. doi:10.1186/1479-5876-12-4 These 3 papers establish leadership in exosome biology and analysis applied to placental development. In particular, through the work of Dr Salomon (a post-doctoral fellow in my group) and Ms Kobayashi (a PhD student in my group), we have improved the “bestpractice” protocol for isolating exosomes and begun to characterise the factors that regulate exosome protein and miRNA content, and their effects on target cells. 4. Peiris HN, Ashman C, Vaswani K, Kvaskoff D, Rice GE, Mitchell MD (2014) Method Development for the Detection of Human Myostatin by High-Resolution and Targeted Mass Spectrometry. J Clin. Endocrinol Metab doi: 10.1210/jc.2014-2615 This paper establishes our expertise in developing and applying mass spectrometry approaches. 5. Rice GE, Scholz-Romero K, Sweeney E, Peiris H, Kobayashi M, Duncombe G, Mitchell MD, Salomon C. (2015) The Effect of Glucose on the Release and Bioactivity of Exosome from First Trimester Trophoblast Cells. J Clin Endocrinol Metab. 2015 Aug 4:jc20152270. [Epub ahead of print] PMID:26241326 This paper delivers proof-of-concept of the involvement of exosomes in glucose homeostatis Page 22
GRANT PROPOSAL – 2016 Centres of Research Application ID: 1135277 Excellence funding commencing 2017 CIA Surname: Rice CI B TRACK RECORD: Prof Paul Colditz Career summary Prof. Colditz is a practicing neonatologist with a DPhil in Medicine from the University of Oxford, UK. He is currently and for the past 20 years has been Director of the Perinatal Research Centre, one of the largest research centres in the School of Medicine and since 2012 also Deputy Director University of Queensland Centre for Clinical Research (UQCCR). His research focuses on clinically important perinatal health problems and translation to clinical practice. It focuses on brain injury, neuroprotection and pathways to improving neurodevelopmental outcomes. Qualifications and dates of award/conferment Institution And Location Degree • Australian Institute Company Directors GAICD 2015 Business • Royal College of Paediatrics and Child Health FRCPCH 1997Medicine • University of Oxford DPhil 1988 Medicine • University of New South Wales, MBiomedE 1985 Engineering • Royal Australasian College of Physicians FRACP 1984 Medicine • University of New South Wales MBBS 1977 Medicine Contribution To The Field/Impact (include translation of research into health outcomes) Prof Colditz has been a lead CI on a number of perinatal randomized controlled trials where the measurement of infant outcomes has been a major component. He was responsible for the acquisition of the southern hemisphere’s first neonatal MRI compatible incubator as an indicator of his interests in accurate determination of outcomes. He has established a multidisciplinary, productive, collaborative, national and international network with paediatricians, neuroscientists, engineers, psychologists and obstetricians. CI Colditz has been granted over AUD$50m in project, equipment and fellowship funding for research, including being CI on 19 NHMRC grants, an NHMRC Practitioner Fellowship, 3 ARC grants and 6 International grants. Prof Colditz’s research group is recognized both nationally and internationally. He has received recognition in both a clinical context (Distinguished Research Medal for Research Excellence (2012) from the Royal Brisbane and Women’s Hospital) and academic context (recipient of University of Queensland of a ‘Top 10’ Q Index Award). Patents He holds an Australian patent (2006 Approved 2006906381) for a method for detecting EEG seizures in a newborn. Collaborations Prof Colditz collaborates with the QLD Cerebral Palsy Research Centre; Children’s Nutrition Research Centre, UQ; the Uni. of Adelaide; Uni. of Sydney; Uni. of Melbourne; Uni. of Cork, and Uni. of Helsinki. He has an ongoing successful collaboration with the Uni. of Qatar, resulting grants >$9M in the last 5 years. Community Engagement & Participation Prof Colditz has a long standing involvement in supporting health consumer and advocacy organisations. He is currently a board member of the national SIDS & Kids Foundation. He has been awarded the Ray Phippard Award for services to medical research by the Lions Medical Research Foundation. In 2013 he was awarded life membership of SIDS & Kids (QLD). Professional Involvement (include committee membership, conference organisation and other service level participation) Page 23
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