APP1135277_Rice_Grant Proposal

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GRANT PROPOSAL – 2016 Centres of Research Application ID: 1135277 Excellence funding commencing 2017 CIA Surname: <strong>Rice</strong> professional achievements and contributions to the NHS in the UK, he was awarded a Bronze/Level 9 Clinical Excellence Award in 2008 at the age of 42 years (The average age to attain this award nationally is 49 years). In 2010/2011, the Times newspaper undertook an exercise to identify Britain's leading specialists based on information from professional bodies. Prof Kumar was one of only 2 fetal medicine specialists on this list. Professional Involvement: In the UK he was a specialist advisor to the National Institute of Clinical Excellence for Fetal Medicine interventional procedures and reviewed some fetal medicine guidelines prior to publication. He was also a clinical advisor to the Healthcare Commission and gave advice on complex cases where local resolution had failed. He organised (since 2008) an annual Clinical Fetal Medicine Course at Imperial College, London which was aimed at advanced and subspecialty trainees in maternal and fetal medicine and specialists involved in perinatal care. This was an extremely popular course and attracted numerous local and international delegates. Prof Kumar has co-authored a RCOG guideline pertaining to the management of women with red cell antibodies in pregnancy. These guidelines influence and guide practice in many different countries. In addition, he was also a member of the Fetal & Neonatal Transfusion sub-committee of the British Committee for Standards in Haematology (BCSH) and contributed to the most recent set of guidelines. At the Mater Mothers’ Hospital/Mater Research Institute he is a member of the Human Research Ethics Committee. International standing: Prof Kumar is regularly invited to speak at international conferences including International Society for Prenatal Diagnosis, RANZCOG/RCOG, International Society of Obstetrics and Gynaecology Ultrasound, Singapore College of Obstetrics & Gynaecology and Hong Kong University. Supervision and/or mentoring: Prof Kumar is currently supervising 7 PhD and 3 Honours students and 8 medical student projects and is leading an RCT investigating the utility of Sildenafil to reduce the risk of intrapartum fetal compromise. In the UK, he has supervised to completion 5 PhD students and 22 Masters students. In the UK, Prof Kumar was Clinical Programme Supervisor for the Maternal & Fetal Medicine Subspecialty training programme at Imperial College as well as preceptor for the Advanced Training Special Skills Module (ATSM) in Fetal Medicine for the Northwest Thames Perinatal Network Peer review involvement: Prof Kumar has reviewed for a number of international journals including Placenta, Prenatal Diagnosis, Journal of Maternal-Fetal Medicine and Neonatology, Journal of Perinatology, Australian & New Zealand Journal of Obstetrics & Gynaecology, Ultrasound in Obstetrics and Gynaecology and PLOSOne. In 2012 he was invited to be an associate editor of the journal Fetal and Maternal Medicine Review, Cambridge University Press. Contribution to the NHMRC and other funding agencies: Prof Kumar has reviewed funding proposals from the NHMRC and Wellcome Trust and other funding bodies. Page 40
GRANT PROPOSAL – 2016 Centres of Research Application ID: 1135277 Excellence funding commencing 2017 CIA Surname: <strong>Rice</strong> Associate Investigator (AI) Contribution, The AI team provides a pathway to end user organisations and will play a significant role within this CRE that will enable to CRE to influence policy and practice locally, nationally and internationally. AI – Professor Leonie Callaway holds a conjoint position as Head, Royal Brisbane Clinical School, and Senior Specialist in Obstetric and Internal Medicine at the Royal Brisbane and Women's Hospital. Prof Callaway is Deputy Chair of the Queensland Maternal and Perinatal Quality Council, and Co-Chair of the Queensland Clinician Scientists Association. Prof Callaway has an outstanding research track record in obesity and inflammation in pregnancy, the role of the maternal metabolism on fetal programming and neonatal body composition, lifestyle interventions in pregnancy, the role of pregnancy in unmasking the risks of future chronic disease and probiotics for the prevention of gestational diabetes mellitus. Prof Callaway is a member of the Council for the Australian Diabetes in Pregnancy Society, and is Deputy Chair of the Queensland Maternal and Perinatal Quality Council. Prof Callaway has an active interest in guideline development to support translation of research into clinical practice. Together with Dekker Nitert is a lead clinical researcher in the SPRING RTC study of probiotics in the prevention of gestational diabetes mellitus in overweight and obese women. Prof Callaway have a critical role in the translation of CRE research outcome into practice and policy change. AI- Professor Alan Rowan is Director of the Australian Institute for Bioengineering and Nanotechnology. He was awarded an ARC laureate in 2016 in the area of biomimetic materials and has active research in the fields of regenerative medicine, wound care, immunotherapy and nanomedicine. He co-director of the UQ StemCare center for stem cell ageing and a board member of the Dow Centre for Sustainable Engineering Innovation. Prof Rowan is co-founder of four spin companies Noviocell, Noviotech, Encapson and Wound-X in the field of biomaterials and their medical applications. Prof Rowan will play a crucial role in the transactional of new technological advances in bio engineering and nanotechnology into clinical practice. In particular, Prof Rowan will contribute to the development of exosome-based diagnostics and the development of new point- of-care medical devices. Prof Rowan will also leverage his extensive industry partnerships to provide in-house opportunities for career development and training for postdoctoral fellows and students involved in the CRE. AI-A/Prof Greg Duncombe is an active clinician scientist, with clinical involvement in many local institutions and access to Australia-wide clinical and basic science collaborations. He is the main clinical lead/connection between the exosome lab scientists at UQCCR and the local obstetric population in regards to fetal and maternal medicine research candidates (including GDM and others) and specimen availability. AI-Duncombe is the current Chair of the Maternal Fetal Medicine Subspecialty (MFM) in Australia and has unparalleled access to subspecialty trainees and colleagues and key responsibilities for development of guidelines. A/Prof Duncombe has played a crucial role in establishing clinical partnerships across the CRE collaborative network. In addition, he has an active collaborator in the exosomes signalling and biomarker aspects of the CRE. AI-A/Prof Anusch Yazdani is Director of Clinical Research and Development at Queensland Fertility Group Research Foundation. He is a distinguished subspecialist in reproductive endocrinology, infertility and minimally invasive pelvic surgery. He is the Program Director for Endoscopic Surgery and Reproductive Endocrinology at Eve Health and Director of Research at the Queensland Fertility Group. A/Prof Yazdani is a collaborator on ART research projects. Within the Queensland Fertility Group (QFG) he has facilitated access to human embryo-conditioned culture media for analysis. QFG staff collect and process these valuable clinical samples for the CRE team Page 41
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APP1135277_Rice_Grant Proposal

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