European Patent Bulletin 2012/30 - European Patent Office
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European Patent Bulletin 2012/30 - European Patent Office

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(A61K) I.1(1)<br />

A61K 31/4709 → (51) A61K 31/40<br />

A61K 31/4745 → (51) C07D 471/04<br />

A61K 31/485 → (51) A61K 9/20<br />

A61K 31/485 → (51) C07D 451/00<br />

(51) A61K 31/495 (11) 2 477 626 A2*<br />

A61K 31/496 A61K 31/4965<br />

A61P 25/24 A61P 25/<strong>30</strong><br />

(25) En (26) En<br />

(21) 10817952.4 (22) 17.09.2010<br />

(84) AL AT BE BG CH CY CZ DE DK EE ES FI FR<br />

GB GR HR HU IE IS IT LI LT LU LV MC MK<br />

MT NL NO PL PT RO SE SI SK SM TR<br />

BA ME RS<br />

(86) US 2010/049405 17.09.2010<br />

(87) WO 2011/035212 2011/12 24.03.2011<br />

(88) 14.07.2011<br />

(<strong>30</strong>) 17.09.2009 US 243464 P<br />

(54) ROLLE VON N-2 HYDROXY-ETHYL-PIPE-<br />

RAZIN-N'-2-ETHAN-SCHWEFELSÄURE<br />

(HEPES) BEI DER SCHMERZSTILLUNG<br />

UND BESEITIGUNG VON DEMYELINISIE-<br />

RUNGSLÄSIONEN<br />

ROLE OF N-2 HYDROXY-ETHYL-<br />

PIPERAZINE-N'-2-ETHANE SULFONIC<br />

ACID (HEPES) IN PAIN CONTROL AND<br />

REVERSAL OF DEMYELINIZATION<br />

INJURY<br />

RÔLE DE L'ACIDE N-2 HYDROXY-ÉTHYL-<br />

PIPÉRAZINE-N'-2-ÉTHANE SULFONIQUE<br />

(HEPES) DANS LA LUTTE CONTRE LA<br />

DOULEUR ET L'INVERSION D'UNE<br />

LÉSION DE DÉMYÉLINISATION<br />

(71) North Texas Medical Associates, 222 Sw 2nd<br />

Street Suite 201, Grand Prairie, TX 75051-<br />

1770, US<br />

(72) DANHOF, Ivan, E., Grand Prairie, TX 75050,<br />

US<br />

(74) Sonn & Partner <strong>Patent</strong>anwälte, Riemergasse<br />

14, 1010 Wien, AT<br />

A61K 31/495 → (51) A01N 43/58<br />

A61K 31/495 → (51) C07D 213/<strong>30</strong><br />

A61K 31/496 → (51) A61K 9/16<br />

A61K 31/496 → (51) A61K 31/495<br />

A61K 31/4965 → (51) A61K 31/495<br />

(51) A61K 31/497 (11) 2 477 627 A1*<br />

A61P 1/10<br />

(25) En (26) En<br />

(21) 10757144.0 (22) 17.09.2010<br />

(84) AL AT BE BG CH CY CZ DE DK EE ES FI FR<br />

GB GR HR HU IE IS IT LI LT LU LV MC MK<br />

MT NL NO PL PT RO SE SI SK SM TR<br />

(86) US 2010/049311 17.09.2010<br />

(87) WO 2011/035142 2011/12 24.03.2011<br />

(<strong>30</strong>) 18.09.2009 US 243616 P<br />

(54) VERWENDUNG EINES OPIODEN REZEP-<br />

TORANTAGONISTEN FÜR ERKRANKEN<br />

DES MAGEN-DARM-TRAKTS<br />

USE OF OPIOID RECEPTOR ANTAGONIST<br />

FOR GASTROINTESTINAL TRACT<br />

DISORDERS<br />

UTILISATION D'UN ANTAGONISTE DE<br />

RÉCEPTEUR D'OPIOÏDE POUR TROU-<br />

BLES DU TRAJET GASTRO-INTESTINAL<br />

(71) Adolor Corporation, 700 Pennsylvania Drive,<br />

Exton, PA 19341, US<br />

(72) WOODWARD, Richard, M., Phoenixville, PA<br />

19460, US<br />

Europäisches <strong>Patent</strong>blatt<br />

<strong>European</strong> <strong>Patent</strong> <strong>Bulletin</strong><br />

<strong>Bulletin</strong> européen des brevets<br />

(74) Cockerton, Bruce Roger, Carpmaels &<br />

Ransford One Southampton Row, London<br />

WC1B 5HA, GB<br />

(51) A61K 31/497 (11) 2 477 628 A1*<br />

A61K 31/675 A61K 31/70<br />

(25) En (26) En<br />

(21) 10817669.4 (22) 02.09.2010<br />

(84) AL AT BE BG CH CY CZ DE DK EE ES FI FR<br />

GB GR HR HU IE IS IT LI LT LU LV MC MK<br />

MT NL NO PL PT RO SE SI SK SM TR<br />

(86) US 2010/047622 02.09.2010<br />

(87) WO 2011/034743 2011/12 24.03.2011<br />

(<strong>30</strong>) 15.09.2009 US 242428 P<br />

12.04.2010 US 32<strong>30</strong>45 P<br />

(54) HERSTELLUNG KRISTALLINER FORMEN<br />

VON DIHYDROPYRAZOLOPYRIMIDINON<br />

PREPARATION OF CRYSTALLINE FORMS<br />

OF DIHYDROPYRAZOLOPYRIMIDINONE<br />

PRÉPARATION DE FORMES CRISTAL-<br />

LINES DE DIHYDROPYRAZOLOPYRIMI-<br />

DINONE<br />

(71) Merck Sharp & Dohme Corp., 126 East<br />

Lincoln Avenue, Rahway, NJ 07065-0907,<br />

US<br />

(72) PETROVA, Rositza, Rahway New Jersey<br />

07065-0907, US<br />

SIROTA, Eric, Rahway New Jersey 07065-<br />

0907, US<br />

WENSLOW, Robert, Rahway New Jersey<br />

07065-0907, US<br />

(74) Hussain, Deeba, et al, Merck & Co., Inc.<br />

<strong>Patent</strong> Department Hertford Road,<br />

Hoddesdon Hertfordshire EN11 9BU, GB<br />

A61K 31/4985 → (51) C07D 471/04<br />

A61K 31/50 → (51) A01N 43/58<br />

A61K 31/513 → (51) A61K 31/5575<br />

A61K 31/517 → (51) C07D 401/12<br />

A61K 31/519 → (51) C07D 498/04<br />

A61K 31/522 → (51) C07D 498/04<br />

(51) A61K 31/535 (11) 2 477 629 A1*<br />

(25) En (26) En<br />

(21) 10817936.7 (22) 17.09.2010<br />

(84) AL AT BE BG CH CY CZ DE DK EE ES FI FR<br />

GB GR HR HU IE IS IT LI LT LU LV MC MK<br />

MT NL NO PL PT RO SE SI SK SM TR<br />

(86) US 2010/049373 17.09.2010<br />

(87) WO 2011/035186 2011/12 24.03.2011<br />

(<strong>30</strong>) 17.09.2009 US 243378 P<br />

(54) SUBSTITUIERTE HETEROARYLAMIDANA-<br />

LOGE ALS MGLUR5-NEGATIVE ALLOS-<br />

TERISCHE MODULATOREN SOWIE VER-<br />

FAHREN ZU IHRER HERSTELLUNG UND<br />

VERWENDUNG<br />

SUBSTITUTED HETEROARYLAMIDE<br />

ANALOGS AS MGLUR5 NEGATIVE<br />

ALLOSTERIC MODULATORS AND<br />

METHODS OF MAKING AND USING THE<br />

SAME<br />

ANALOGUES D'HÉTÉROARYLAMIDE<br />

SUBSTITUÉ EN TANT QUE MODULA-<br />

TEURS ALLOSTÉRIQUES NÉGATIFS DE<br />

MGLUR5, ET LEURS PROCÉDÉS DE<br />

PRÉPARATION ET D'UTILISATION<br />

(71) Vanderbilt University, <strong>Office</strong> Of Technology<br />

Transfer <strong>30</strong>5 Kirkland Hall, Nashville,<br />

Tennessee 37240, US<br />

(72) CONN, P., Jeffrey, Brentwood, TN 37027, US<br />

LINDSLEY, Craig, W., Brentwood, TN 37027,<br />

US<br />

EMMITTE, Kyle, A., Spring Hill, TN 37174,<br />

US<br />

38<br />

Anmeldungen<br />

Applications<br />

Demandes (<strong>30</strong>/<strong>2012</strong>) 25.07.<strong>2012</strong><br />

WEAVER, Charles, David, Franklin, TN<br />

37067, US<br />

RODRIGUEZ, Alice, L., Nashville, TN 37209,<br />

US<br />

FELTS, Andrew, S., Hermitage, TN 37076,<br />

US<br />

JONES, Carrie, K., Nashville, TN 37204, US<br />

BATES, Brittney, S., Nashville, TN 37215, US<br />

(74) Warner, James Alexander, et al, Carpmaels &<br />

Ransford One Southampton Row, London<br />

WC1B 5HA, GB<br />

(51) A61K 31/535 (11) 2 477 6<strong>30</strong> A1*<br />

(25) En (26) En<br />

(21) 10817950.8 (22) 17.09.2010<br />

(84) AL AT BE BG CH CY CZ DE DK EE ES FI FR<br />

GB GR HR HU IE IS IT LI LT LU LV MC MK<br />

MT NL NO PL PT RO SE SI SK SM TR<br />

(86) US 2010/049400 17.09.2010<br />

(87) WO 2011/035209 2011/12 24.03.2011<br />

(<strong>30</strong>) 17.09.2009 US 243378 P<br />

(54) SUBSTITUIERTE BENZAMIDANALOGA<br />

ALS NEGATIVE ALLOSTERISCHE<br />

MGLUR5-MODULATOREN SOWIE VER-<br />

FAHREN ZU IHRER HERSTELLUNG UND<br />

VERWENDUNG<br />

SUBSTITUTED BENZAMIDE ANALOGS AS<br />

MGLUR5 NEGATIVE ALLOSTERIC MODU-<br />

LATORS AND METHODS OF MAKING<br />

AND USING THE SAME<br />

ANALOGUES DE BENZAMIDE SUBSTITUÉ<br />

EN TANT QUE MODULATEURS ALLOSTÉ-<br />

RIQUES NÉGATIFS MGLUR5, ET LEURS<br />

PROCÉDÉS DE PRÉPARATION ET D'UTI-<br />

LISATION<br />

(71) Vanderbilt University, <strong>Office</strong> Of Technology<br />

Transfer <strong>30</strong>5 Kirkland Hall, Nashville,<br />

Tennessee 37240, US<br />

(72) CONN, P., Jeffrey, Brentwood, TN 37027, US<br />

LINDSLEY, Craig, W., Brentwood, TN 37027,<br />

US<br />

EMMITTE, Kyle, A., Spring Hill, TN 37174,<br />

US<br />

WEAVER, Charles, David, Franklin, TN<br />

37067, US<br />

RODRIGUEZ, Alice, L., Nashville, TN 37209,<br />

US<br />

FELTS, Andrew, S., Hermitage, TN 37076,<br />

US<br />

JONES, Carrie, K., Nashville, TN 37221, US<br />

BATES, Brittney, S., Nashville, TN 37215, US<br />

(74) Warner, James Alexander, Carpmaels &<br />

Ransford One Southampton Row, London<br />

WC1B 5HA, GB<br />

(51) A61K 31/535 (11) 2 477 631 A1*<br />

(25) En (26) En<br />

(21) 10817954.0 (22) 17.09.2010<br />

(84) AL AT BE BG CH CY CZ DE DK EE ES FI FR<br />

GB GR HR HU IE IS IT LI LT LU LV MC MK<br />

MT NL NO PL PT RO SE SI SK SM TR<br />

(86) US 2010/049407 17.09.2010<br />

(87) WO 2011/035214 2011/12 24.03.2011<br />

(<strong>30</strong>) 17.09.2009 US 243378 P<br />

(54) SUBSTITUIERTE PHENYLAMIN-CARBO-<br />

XAMID-ANALOGA ALS NEGATIVE AL-<br />

LOSTERISCHE MGLUR5-MODULATOREN<br />

SOWIE VERFAHREN ZU IHRER HER-<br />

STELLUNG UND VERWENDUNG<br />

SUBSTITUTED PHENYLAMINE<br />

CARBOXAMIDE ANALOGS AS MGLUR5<br />

NEGATIVE ALLOSTERIC MODULATORS<br />

AND METHODS OF MAKING AND USING<br />

THE SAME<br />

ANALOGUES DE CARBOXAMIDE<br />

SUBSTITUÉ EN TANT QUE MODULA-<br />

TEURS ALLOSTÉRIQUES NÉGATIFS<br />

MGLUR5 ET LEURS PROCÉDÉS DE<br />

PRÉPARATION ET D'UTILISATION

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