SUMOylation and DeSUMOylation at a Glance - Journal of Cell ...

Journal of Cell Science
4252
Journal of Cell Science 122 (23)
heterodimer acts similarly in budding yeast
(Hunter and Sun, 2008). The functions of Rfp1
and/or Rfp2 and Slx8 are performed by a single
protein in human cells, RING-finger protein 4
(RNF4), which is the only confirmed
mammalian STUbL (Sun et al., 2007).
Perspectives
Findings during the last 5 or 6 years have
provided a much more sophisticated
understanding of the SUMOylation pathway,
revealing some aspects that are unique to this
pathway and others that are probably common
to pathways involving all ubiquitin-like
proteins. However, the picture of SUMOylation
is not yet complete, and we expect that studies of
the SUMO pathway may yet hold more
surprises. In particular, we look forward to
future findings regarding the mechanisms of
SUMO ligases and the possibility that additional
SIMs remain to be discovered. Finally, we still
have much to learn regarding the biological
functions of this pathway and its interaction with
ubiquitin and other regulatory pathways.
This work was supported through Eunice Kennedy
Shriver National Institute of Child Health and Human
Development Intramural funds (Z01 HD001902).
Deposited in PMC for release after 12 months.
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