Oxidative And Nitrosative Modulators In Neuroinflammation
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OXIDATIVEANDNITROSATIVEMODULATORSINNEUROINFLAMMATION<br />
Thepresenceofoligoclonaltape(OKT+)ontheisoelectricfocusingofthecerebrospinalfluidandserum in<br />
relationtothenumberofKISpatients(15patients)withOKT+,p=0.025,wasdemonstratedinalarge<br />
numberofRRMSpatients(54patients).TheKMBdisorder,definedasanincreaseinthealbuminconcentrationinthedrugrelativetoserum<br />
levels>7.0x10-3,wasobservedin7KISand11RRMSpatients.<strong>In</strong>other<br />
patients,thediferencesintheassessmentofpermeabilityofKMBbetweentheKIS(5.9±0.95)andRRMS<br />
(6.2±0.7)patientswerenotstatisticalysignificant(p=0.08).Thetotalproteinconcentrationsinthecere-<br />
brospinalfluidwerehigherinRRMS(0.42±0.23g/L)comparedtopatientsoftheKISgroup(0.32±0.13<br />
g/L),p=0.032.Nostatisticalysignificantdiferenceinalbuminconcentrationinthecerebrospinalfluid<br />
wasobservedbetweenKIS(0.25±0.1g/L)andRRMSpatients(0.27±0.1g/L),p=0.07.Also,comparing<br />
totalplasmaproteinconcentrationsbetweenKIS(64.2±12g/L)andRRMS(60.2±10.2g/L)groups,and<br />
plasmaconcentrationsofalbuminKIS(42.3±9.5g/L)andRRMS(43.9±11.1g/L)groups,statisticaly<br />
significantdiferenceswerenoticed,p=0.072ip=0.084.<br />
-NeurologicalfindingsofKISandRRMSpatients:Themajorityofpatientswerefoundtohavesymptoms<br />
andsignsofafectionofmorethanoneCNSfunctionalsystem,inbothKIS(35patients)andRRMSgroup<br />
(47patients),p=0.035(KISvs.RRMS).<strong>In</strong>otherpatients,bothgroupsofthedominantneurologicalfindings<br />
werepyramidal(KIS-11,RRMS-9patients),p=0.075,andsensory(KIS-3,RRMS-1patient)damage,as<br />
welasvisualimpairment(KIS-1patient).Statisticalsignificancewasobservedinthediferenceinthedu-<br />
rationofthesymptomsuntilthepatientarivedatahospitaltreatmentinaKISpatientwithalarger(me-<br />
dianvalueof1month(1-12months)comparedtoKISpatientswithasmalerEDSS(Medianvalue4<br />
months(1-12months),p=0.025.Bycomparingthedurationofthedisease(from themomentofdiagnosis<br />
ofthedefinitiveRRMS),itwasfoundthatRRMSpatientswithahigherEDSShavealongerdurationofthe<br />
disease(medianvalue96months(8-396months)comparedtothosewithalowerEDSS(medianvalue46<br />
months(1-250months)(p=0.0013).ComparisonofotherobtainedvaluesinsubgroupsofKISandRRMS<br />
patientsdividedbyEDSSfindingsdidnotshowstatisticalysignificantdiferences(p>0.05).<br />
-RadiologicalfindingsofKISandRRMSpatients:Datarelatedtotheradiologicalfindingindicatethatthe<br />
existenceofT2hyperintensesignals(p=0.035,RRMSvs.KIS)wasobservedin37patientsintheKISgroup<br />
andalRRMSpatients.ThesedatawereobtainedbasedontheresultsoftheMRconductedduringthecurrenthospitalization,aswelastheinsightintotheearliermedicalrecordsofpatients.Forthepurposesof<br />
moredetailedanalysisinthisstudy,onlyMRfindingsthatweremadeduringthecurenthospitalization<br />
wereusedin16patientswithKISand15patientsintheRRMSgroup.Itwasfoundthatthetotalnumber<br />
andnumber
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