Oxidative And Nitrosative Modulators In Neuroinflammation

OXIDATIVEANDNITROSATIVEMODULATORSINNEUROINFLAMMATION
ofsupranuclearhyperintensesignalsseenontheT2sequencewasstatisticalysignificantlyhigherinthe
RRMSgroupofpatients(medianvalueforthetotalnumberoflesionsandthenumberofsupratentorallo-
numberofsupratentorallesions-8(0-80),p=0.023ip=0.03.ThevolumeofGdbindinglesionsseenon
theT1sequencewasstatisticalysignificantlyhigherintheRRMSgroup,bothinthebrain(277.7±109.1
mm3)andinthebiomass(641.3±210.2.1mm3),incomparisonwiththesamefindinginthebrain(146.5±
46.8mm3)andcysticmoss(446.6±120.1mm3)ofpatientsintheKISgroup,p=0.031(forthebrain),p=
0.04.
-Concentrationsofexaminedparametersinrelationtopatientage:Itwasfoundthatolderpatientshad
calizationlesions-40(5-84supratentoral,3-70infratentionallocalization)comparedtothesamecharac-
teristicsinKISpatients(medianvalueforthetotalnumberoflesions-9(0-56),medianvalueforthetotal
higherconcentrationsofNO2andNO3comparedtoyoungerpatients,andinKIS(plasma-p=0.034,cere-
brospinalfluid-p=0.04),andintheRRMSgroup(plasma-p=0.03;cerebrospinalfluid-p=0.025).Simi-
larly,theconcentrationofMDAinalinvestigatedmediawashigherintheelderlygroupcomparedto
youngerpatients,inbothexaminedgroups,KIS(plasma-p=0.07;cerebrospinalfluid-p=0.06;hemolysate-p=0.09),andintheRRMSgroup(plasma-p=0.055;cerebrospinalfluid-p=0.065;hemolysate-p=
0.06).AOPPconcentrationsincreasedinthegroupofelderlypatientsandinKIS(plasma-p=0.05;cerebro-
observedinelderlypatientscomparedtoyoungerandKIS(plasma-p=0.025,cerebrospinalfluid-p=0.04,
inKIS(plasma-p=0.065;cerebrospinalfluid-p=0.031;haemolysate-p=0.05)andinRRMSpatients
(plasma-p=0.025;-p=0.07).
-Concentrationsofexaminedparametersinrelationtohalfofpatients:Analysisoftheobtainedvaluesof
thetestedparameters,comparedtohalfofpatients,itwasfoundthatmenhavehighervaluesofNO2and
NO3concentrationsinrelationtowomen,andinKIS(plasma-p=0,06,cerebrospinalfluid-p=0,075),and
spinalfluid-p=0.06;hemolysate-p=0.055),andintheRRMSgroup(plasma-p=0.06;=0.04;hemoly-
sate-p=0.095).Atthesametime,thedecreaseinSHvaluesinplasmaandliver,GSHinhemolysateswas
hemolysate-p=0.9)andinRRMSpatients(plasma-p=0.015;cerebrospinalfluid-p=0.035;hemolysatep=0.75).ThetrendofdeclineintheactivityofSODwiththeincreaseintheyearsoflifewasalsoobserved
intheRRMSgroup(plasma-p=0,065;cerebrospinalfluid-p=0,023).TheconcentrationofMDAinalinvestigatedmediawasselectivelyhigherinwomencomparedtomen,inbothexaminedgroups,KIS(plasma
-p=0.078,cerebrospinalfluid-p=0.045,hemolysate-p=0.9),andintheRRMSgroup(plasma-p=0.85;
cerebrospinalfluid-p=0.95;hemolysate-p=0.6).