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Literature Review on Childhood Obesity Sample

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LITERATURE<br />

REVIEW ON<br />

CHILDHOOD<br />

OBESITY<br />

SAMPLE


<strong>Childhood</strong>obesity-anew multidisciplinary<br />

problem lookingforpreventi<strong>on</strong>programs<br />

Withthedevelopmentofmoderndiagnoscandtherapeucpossibilies,theindicators<br />

ofvitalstascs,thecauseofmorbidityandmortalityofthepopula<strong>on</strong>,arechanged,<br />

withtheincreaseoftheso-caledchr<strong>on</strong>icNIH n<strong>on</strong>-communicablediseases(Rhodes&<br />

Ludwig,2007).<strong>Obesity</strong>becomesan increasinglyimportantpublichealth problem<br />

becauseofthedrascincreaseinitsincidence,not<strong>on</strong>lyinadultsbutinchildrenandadolescents,whichdirectlyandindirectlyaffectsmorbidity,thelifeexpectancy,andalsothe<br />

mortalityofpopula<strong>on</strong>(Bibbins-Domingoetal.,2007;Reuseretal.,2008).<strong>Obesity</strong>in<br />

childrenandadolescentscausesaen<strong>on</strong>asadiseaseitself,butalsobecauseofitssec<strong>on</strong>daryinfluences(Bessesen,2008).Geneinheritance,familyenvir<strong>on</strong>ment,socio-ec<strong>on</strong>omicandculturalc<strong>on</strong>di<strong>on</strong>s,everydayhabitsaffecttheappearanceofobesitythrough<br />

mutualinterac<strong>on</strong>.Theprogram forthepreven<strong>on</strong>ofobesitygainincreasedaen<strong>on</strong><br />

duetothelimitedpossibiliesofitsmedica<strong>on</strong>andsurgicaltreatmentguidelinesin<br />

children(Spearetal.,2007).Byreviewingtheliterature,itmaybenotedthattheviews<br />

<strong>on</strong>obesitypreven<strong>on</strong>programsaredivided.Someauthorsbelievethatobesitypreven-<br />

<strong>on</strong>programs,beginningwithchildhood,arekeytocounteracngthis"pandemicofthe<br />

new milennium"(Goldschmidtetal.,2008;Bovetetal.,2008)whileothersques<strong>on</strong>the<br />

effecvenessandusefulnessofsuchprograms(Bo<strong>on</strong>&Clydesdale,2005;Krukowskiet<br />

al.,2008).<br />

Dataknowledgeofobesityinaparcularpopula<strong>on</strong>isthestarngpointforplanning<br />

andimplemenngprogramsforitspreven<strong>on</strong>.However,itshouldbepointedoutthatit<br />

isoenrelavelydifficulttocomparetheresultsofepidemiologicalstudiesfrom differentgeographicareas,astheydiffersignificantlyinthechoiceofmetabolicanddiagnosc<br />

indicatorsofobesitybutalsobased<strong>on</strong>thevalues ofthereferenceorstandardvalues<br />

withwhichtheyarecompared.Anincreaseintheprevalenceofobesityatanearlyage,<br />

bothdevelopedanddevelopingcountries,raisesthec<strong>on</strong>cernofsocietyasawhole<br />

becauseofitsdirectandindirectimpact<strong>on</strong>popula<strong>on</strong>healthanditssignificant<br />

ec<strong>on</strong>omicc<strong>on</strong>sequences.Changesinthewaylifeandfunc<strong>on</strong>ingofmodernfamiliesas<br />

welasposiveseculargrowthinbodymass,heightandbodymassindex(ITM)favored<br />

theincreaseinobesityinchildhood.Duringthelasttwentyyearsinthedevelopedworld,<br />

inthemajorityofobesity,nearly10% oftheworld'schildrenareobeseorobesefor<br />

obesity(Bessesen,2008).AccordingtoWorldHealthOrganiza<strong>on</strong>(WHO)worldwide,<br />

1.7trili<strong>on</strong>peopleareatriskfordevelopingobesityand310mili<strong>on</strong>areobese.<br />

(Hp:/www.who.int/topics/obesity/en/).Infact,obesityisanincreasinglyprevalent<br />

problem inthepre-schoolage,especialyintheMiddleEast,NorthandLanAmerica,<br />

withanaverageprevalenceof3.3%.


<strong>Childhood</strong>obesity-anew multidisciplinary<br />

problem lookingforpreventi<strong>on</strong>programs<br />

Interesngly,studiesshow agreatercumulaveincidenceofmalnutri<strong>on</strong>andobesity<br />

thanpre-schoolchildrenfrom socialydeprivedintheenvir<strong>on</strong>mentwithappropriate<br />

socio-ec<strong>on</strong>omicopportuniesinwhichchildrengrow up(9.5% to6.9%)(Armstr<strong>on</strong>get<br />

al.,2003).<br />

Analysisofthepresenceof<strong>on</strong>eormoreriskfactorsforobesitydevelopmentisanecessarystepinplanningaprogram<br />

forobesitypreven<strong>on</strong>.Itisknownthattheinheritance,<br />

reindeermass,thelengthofbreaseeding,theageatwhichthefeedingwasintroduced<br />

andtheso-caledsitedwayofourlivesaffectstheappearanceofobesechildren.<br />

Althoughnumerousgenelocusandknownhereditaryobesitymechanisms(lepnmuta-<br />

<strong>on</strong>s,lepnreceptors,neuropepdeY,proopiomelanocorn,prohorm<strong>on</strong>ec<strong>on</strong>vertase1,<br />

melanocornreceptorMCR4 .)havebeendiscovered,theinterpreta<strong>on</strong>ofgenec<br />

obesityresearchisslverycomplex.M<strong>on</strong>ogenousobesity,aswelassec<strong>on</strong>daryobesity<br />

thatappearsaspartofsomeendocrinedisorders(hypothyroidism,Cushing'ssyndrome,<br />

corcosteroid therapy,lackofgrowth horm<strong>on</strong>e,hyperinsulinis,type2 diabetes,<br />

pseudohipoparataireoidism,centralnervoussystem lesi<strong>on</strong>s(tumorsHypothalamus)or<br />

syndrome(Prader-Wili,Laurence-Mo<strong>on</strong>-Biedlsy,Alstrom syndrome,Mauriac<br />

syndrome,Cohensyndrome .),occurrelavelyrarely.From apublichealthpointof<br />

view,aen<strong>on</strong>isdrawntobafflingobesity,whichaccountsformorethan95% ofits<br />

overalprevalence.Analyzingthepathophysiologicalbackgroundforobesitydevelopment,butalsotheresp<strong>on</strong>seofanindividualtotheinterven<strong>on</strong>measurestaken,theinvesgator'saen<strong>on</strong>isparcularlyc<strong>on</strong>ducivetotheinterplayofgenecpredisposi<strong>on</strong>and<br />

envir<strong>on</strong>mentalfactors.Theliteraturedescribesasignificantassocia<strong>on</strong>betweenobesityof<br />

parentsandchildren(Magarey,2003),whichisexplainedbythemutualac<strong>on</strong>ofhereditary<br />

andsocio-ec<strong>on</strong>omicfactors.Childrenwhoseobstetricsareobese,especialyiftheirweightis<br />

greaterthan4000grams,needenhancedsurveilanceinthesenseofpreven<strong>on</strong>forobesity,<br />

asshownbytheresultsofLakeetal.(1997).<br />

ComprehensivereviewworkbyBairdetal.based<strong>on</strong>theresultsof24studies,suggeststhat<br />

thevalueofreindeermass,theform inwhichthechildgrowsduringchildhood,especialythe<br />

rateofgrowth,affectstheappearanceofobesityduringchildhoodbutalsoofadulthood<br />

(2005).Earlyeanghabitsmayalsoaffectobesityinchildrenandadolescents,although<br />

somestudiesd<strong>on</strong>otcorelatetheeffectofbreaseeding<strong>on</strong>thelevelofobesity.<br />

ThestudybyGilmanetal.showedthatbreaseedingandbreastlengthhaveaprotecveeffect<strong>on</strong>obesityduringchildhoodandadolescence(2001).AccordingtoProcter,<br />

theprotecveeffectofl<strong>on</strong>g-term breaseeding<strong>on</strong>theriskofdevelopingobesityatage<br />

4isenhancedbytheac<strong>on</strong>ofculturalyandgeneralyfavorableenvir<strong>on</strong>mentalfactors<br />

(2008).


<strong>Childhood</strong>obesity-anew multidisciplinary<br />

problem lookingforpreventi<strong>on</strong>programs<br />

Pubertyisaperiodduringwhichvariousriskfactorsaregroupedtofavortheenre<br />

rangeoffeedingdisorder,rangingfrom obesitytootherextremiessuchasanorexiaand<br />

bulimia.Itiswelknownthatchildrenareobesetothoselookingforl<strong>on</strong>gertelevisi<strong>on</strong>or<br />

playingcomputergamesthanthosewhod<strong>on</strong>othavethathabit.Byspendinghoursin<br />

fr<strong>on</strong>toftheTV,childrenusualytakealargeamountof"snacks"and"fast"food,andat<br />

thesamemedoesnotc<strong>on</strong>sumeenergyduetophysicalinacvity,whichc<strong>on</strong>tributesto<br />

theappearanceofobesityatalages .<br />

Primaryobesitypreven<strong>on</strong>isfocused<strong>on</strong>theindividual,butalso<strong>on</strong>theenrepopula<strong>on</strong>withanappropriatebodymassforprom<strong>on</strong>g,educangandadopnghealthy<br />

eanghabitsandthegeneralwayoflife.(ITM of18.5to24.9kg/m2foradults,or<br />

equivalentbyageandsexforchildrenorbetween5.and85percentbodyweightofITM<br />

forageandgender).Atthepopula<strong>on</strong>levelaspartofprimaryobesitypreven<strong>on</strong>,popula<strong>on</strong>educa<strong>on</strong><strong>on</strong>theeffectofexcessivebodymass,i.e.obesity<strong>on</strong>theoccurenceof<br />

earlycardiovascularandmetabolicdiseases,aswelas<strong>on</strong>theeffectofobesity<strong>on</strong>the<br />

reduc<strong>on</strong>ofexpectedlifeexpectancyandmortalityofthepopula<strong>on</strong>.Intheulmate<br />

sense,targetgroupsofprimaryobesitypreven<strong>on</strong>arepregnantwomen,pre-schooland<br />

schoolchildren,whoshouldbetaughtthroughl<strong>on</strong>g-lasngeduca<strong>on</strong>withinthedifferentlevelsofhealthandeduca<strong>on</strong>systemstohelptheirfamiliesandcommuniesin<br />

growinguptoadoptpropereanghabitsandageneralyhealthywayoflife.Prenatal<br />

age,earlychildhoodandparcularlyadolescentageduringwhichtheriskfactorsare<br />

grouped,butalsochangesinbehaviorsandthegeneralwayoflifeareknowntoberisky<br />

periodsofobesity.Primaryobesitypreven<strong>on</strong>actualybeginspre-c<strong>on</strong>cep<strong>on</strong>and<br />

duringtheantenatalperiod,educangpregnantwomenabouttheeffectofherbody<br />

weightgain<strong>on</strong>pregnancy<strong>on</strong>obesity.Starngfrom theunderstandingoftheprotecve<br />

effectofbreaseeding<strong>on</strong>childhoodobesity,primarypreven<strong>on</strong>shouldincludeacvi-<br />

estofurthersmulateandpromoteexisngprogramstosmulatebreaseedingand<br />

introducecomplementarydietsaccordingtoexisngexpertadvice.<br />

Primaryobesitypreven<strong>on</strong>duringpre-schoolageisfocused<strong>on</strong>:-Adopnghealthy<br />

nutri<strong>on</strong>habitsandahealthywayoflife:regularityofmeals(threemainandtwosnacks),<br />

Thisisaparcularlycomplexproblem becausethec<strong>on</strong>sequencesofviolencearetransferednot<strong>on</strong>lytootherfamilymembers,buttothenextgenera<strong>on</strong>s,whichisless<br />

comm<strong>on</strong>intheresearchfocusthanthetransferofviolencefrom worktofamilyandvice<br />

versa.<br />

Aggressi<strong>on</strong>andviolencearesocialphenomenathatarehighlycorelated,causally-c<strong>on</strong>sequentlyrelatedt<strong>on</strong>umeroussocio-pathologicalphenomena:


<strong>Childhood</strong>obesity-anew multidisciplinary<br />

problem lookingforpreventi<strong>on</strong>programs<br />

socialdiseases(somac,mental,psychosomac);individualandsocialdisorganiza-<br />

<strong>on</strong>sanddysfunc<strong>on</strong>s(pre-mariage,extra-maritalandmaritalcommunies,family,<br />

school,spiritualinstu<strong>on</strong>s,narow andwidersocialcommunity),socio-pathological<br />

phenomena(smoking,alcoholism,drugaddic<strong>on</strong>,sexualabuseandviolence,aggressi<strong>on</strong>-destruc<strong>on</strong>,murderandsuicide)andcrime.Childrenwhoexperienceviolencemore<br />

oenaremoreviolenttowardsotherchildren.Thisisimportantforunderstandingthe<br />

psychologicalaspectofthephenomen<strong>on</strong>ofviolence,aswelasfordeterminingthe<br />

cause-effectrela<strong>on</strong>shipbetweenexperiencedandcommiedviolence.Interven<strong>on</strong>s<br />

thatpromoteasafe,stableandgentleassocia<strong>on</strong>ofachildwiththeirparentsatanearly<br />

agecanpreventaggressi<strong>on</strong>(WHO,2010).Acvies,rolesandrela<strong>on</strong>shipswithother<br />

peoplewithinthec<strong>on</strong>textoflifedeterminethedevelopmentofanindividualbyspreadingc<strong>on</strong>texts(e.g.school,localcommunity,state,etc.)causingchangesinthepers<strong>on</strong>'s<br />

system,andchangingthesystem leadstoachangeofbehavior.(Br<strong>on</strong>fenbrenner,2005).<br />

Inthetheoryofecologicalsystems,Br<strong>on</strong>fenbrenner(2005)c<strong>on</strong>cludesthattherearefive<br />

ecologicalsystems(biosystem,microsystem,mesosystem,ecosystem andmacrosystem)<br />

betweenwhichthereisacomplexinterac<strong>on</strong>andstr<strong>on</strong>ginterdependenceandacrucial<br />

influence<strong>on</strong>thedevelopmentoftheindividual.Thecharacteriza<strong>on</strong>ofaggressiveness<br />

asanecologicalphenomen<strong>on</strong>istheemphasisandemphasis<strong>on</strong>thecomplexinterac<strong>on</strong><br />

ofintraindividualandinterindividualvariables.Violenceisnotanisolatedphenomen<strong>on</strong>.<br />

Itaffectseverythingthathappensinanarowerandwiderenvir<strong>on</strong>ment,andinorderto<br />

understandit,alaspectsofitsorigin,manifesta<strong>on</strong>andpersistencemustbetakeninto<br />

account.Individualcharacteriscsareinfluencedbydifferentecologicalc<strong>on</strong>texts,such<br />

asschools,peergroups,thewidercommunity,andso<strong>on</strong>.(Br<strong>on</strong>fenbrenner,2005),andits<br />

keysourceiscertainlythefamilyinitsbasicdefini<strong>on</strong>ofexistenceandbiological,psychologicalandsocialfunc<strong>on</strong>ing.Intheorecalc<strong>on</strong>sidera<strong>on</strong>s,asintheprevious<br />

researchplans,severalgroupsoffactorsc<strong>on</strong>sideredasriskyforviolentbehaviorcanbe<br />

observed:familyandgenecfactors,disruptedsocialcogni<strong>on</strong>,socio-ec<strong>on</strong>omicstatus<br />

ofthefamily,waterasadrink,twocupsofmilkaday,wholegrainbread,n<strong>on</strong>-fatmeat,<br />

bluefish,freshseas<strong>on</strong>alfruitsandvegetables,vegetableoilextracts(olive,wheat,corn<br />

oil.)introduceavarietyofnutri<strong>on</strong>,takingintoaccountthechild'senergyandnutri<strong>on</strong>al<br />

needsduringthatgrowthanddevelopmentperiodPrevenngdietaryhabitsinfamiliesand<br />

pre-schoolinstu<strong>on</strong>stoencourageeverydayphysicalacvity,mec<strong>on</strong>straints<strong>on</strong>watching<br />

TV,playingvideogamesandcomputergames.Primarypreven<strong>on</strong>ofobesityduringthe<br />

schoolage:Bychoosingtherightchoiceandquantyoffoodstomeettheincreasedenergy<br />

andnutri<strong>on</strong>alneedsduringthisperiodofintensegrowthandmaintainingdevelopmentand


<strong>Childhood</strong>obesity-anew multidisciplinary<br />

problem lookingforpreventi<strong>on</strong>programs<br />

prom<strong>on</strong>ghealthyeanghabits,restricngtheimplementa<strong>on</strong>ofrestricvedietsinthe<br />

senseofprevenngsome<strong>on</strong>efrom eangdisorders,especialyforgirls,daily,recrea<strong>on</strong>alphysicalacvityofatleast30to60minutes<strong>on</strong>theday,preven<strong>on</strong>ofsmoking,<br />

alcohol,narcoc,unhealthy,unc<strong>on</strong>troleddietarysupplements.<br />

Primaryobesitypreven<strong>on</strong>isal<strong>on</strong>g-lasng,comprehensiveprocessofthesocial<br />

communityasawhole.Thesuccessofprimarypreven<strong>on</strong>requiresthesupportof<br />

variousministries(MinistryofHealthandSocialWelfare,MinistryofEduca<strong>on</strong>,Ministry<br />

ofTransportandCommunica<strong>on</strong>s),butalsotheacvityofn<strong>on</strong>-governmentalorganiza-<br />

<strong>on</strong>sandsociees("OurChildren","HealthyCies"etc.).Primaryobesitypreven<strong>on</strong>is<br />

anextremelydemandingprogram foralparcipantsbecauseitisfounded<strong>on</strong>the<br />

l<strong>on</strong>g-term,immediateworkofhealthandeduca<strong>on</strong>workers,includingthemediawith<br />

individualsaswelaswiththepopula<strong>on</strong>.Theresultsofprimaryobesitypreven<strong>on</strong>can<br />

<strong>on</strong>lybec<strong>on</strong>sideredinthel<strong>on</strong>gterm,whichmaybeitsmainlimita<strong>on</strong>asregardsthe<br />

problem ofsustainingthemova<strong>on</strong>ofalitsparcipants(Stenderetal.,2005).<br />

Theunderlyingsec<strong>on</strong>darypreven<strong>on</strong>ofobesityisthedefini<strong>on</strong>ofriskgroupsfor<br />

obesitydevelopment.Sec<strong>on</strong>darypreven<strong>on</strong> programsincludechildren andyoung<br />

peoplewho,based<strong>on</strong>theirinheritance,anamnesisaboutthefamily'stendencyto<br />

obesity,thesedentarymodeoflifehaveapredisposi<strong>on</strong>tobecomeobese.Sec<strong>on</strong>dary<br />

obesitypreven<strong>on</strong>programsincludechildrenandyoungpeoplewhoseobesityis<strong>on</strong>eof<br />

thedeterminantsoftheunderlyingdisease(endocrinopathy,syndrome).Sec<strong>on</strong>darypreven<strong>on</strong>isdirectedattheindividual,i.e.thepopula<strong>on</strong>oftargetpredisposingagegroups,<br />

whichhasanITM of85to95percenleforageandgender,coresp<strong>on</strong>dingtoanequivalentof25to29.9kg/m2byageandsex.Thedefinedriskgroupsaretaughtaboutthe<br />

importanceofc<strong>on</strong>trolandmaintenanceofbodymasstopreventthedevelopmentof<br />

somechr<strong>on</strong>icdiseasesassociatedwithobesity,whichcansignificantlyaffectnot<strong>on</strong>ly<br />

thelengthbutalsothequalityoftheirfurtherlife.Adopngknowledgeabouttheimportanceofc<strong>on</strong>trolingappropriatebodymassisaprerequisiteformovanganindividual,<br />

butalsoforafamilyenvir<strong>on</strong>ment.Childrenandadolescentsbel<strong>on</strong>gingtothegroupof<br />

obesity-inducedobesityarel<strong>on</strong>gitudinalym<strong>on</strong>itoredbyclinicalandlaboratorym<strong>on</strong>itoringofthebasicparameters(bloodpressure,bloodglucoselevel,lipidogra,hepatogram,<br />

CRP,urine .),whichcouldpointtothedevelopmentofsomediseasesthatmayariseas<br />

aresultofobesity.<br />

C<strong>on</strong>sideringtheproblem ofobesityinchildrenintermsofitsdynamics,itisslanopen<br />

ques<strong>on</strong>inwhichcasesandatwhatagetheprimaryhealthcarepediatricianshouldreferthe<br />

obesechildtosubspecialistsformoredetaileddiagnoscandtherapeucprocedures.


<strong>Childhood</strong>obesity-anew multidisciplinary<br />

problem lookingforpreventi<strong>on</strong>programs<br />

References<br />

Rhodes,E.T.,Ludwig,D.S.(2007).<strong>Childhood</strong>obesityasachr<strong>on</strong>icdiseasekeepingthe<br />

weightoff.JAMA298,p.1695-6.<br />

Bibbins-Domingo,K.,Coxs<strong>on</strong>,P.,Pletcher,M.J.,Lightwood,J.,Goldman,L.(2007)Adolescentoverweightandfutureadultcor<strong>on</strong>aryheartdisease.NEJM<br />

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Bovet,P.,Chiolero,A.,Paccaud,F.(2008)Epidemiologyandpreven<strong>on</strong>ofoverweightin<br />

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Gilman,M.W.,Rifas-Shiman,S.L.,Camargo,C.A.Jr.,Berkey,C.S.,Frazier,A.L.,Rocke,H.<br />

R.,Field,A.E.,Colditz,G.A.(2001)Riskofoverweightam<strong>on</strong>gadolescentswhowerebreased<br />

asinfants.JAMA285,p.2461-7.<br />

Procter,S.B.,Holcomb,C.A.(2008)Breaseedingdura<strong>on</strong>andchildhoodoverweight<br />

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