AG&M annual report 2018
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Michel van Weeghel<br />
After a study in biomedical sciences, I started a PhD in biochemistry and<br />
metabolic diseases and performed a postdoc in analytical chemistry at<br />
the university of Leiden. Currently, I am the manager of the Core Facility<br />
Metabolomics (CFM) at the Amsterdam UMC, location AMC. The focus<br />
of the CFM is to develop and improve analytical methods to measure<br />
a wide range of metabolites in several matrices. My ambition is to<br />
maintain and expand the CFM in terms of state-of-art instrumentation<br />
and personnel. The analytical focus will be on developing new strategies<br />
in the metabolomics research field, including the development of tracerbased<br />
metabolomics. I believe that metabolomics will be able to help us<br />
understand metabolism in a broad sense and will be useful for several<br />
research disciplines within the AG&M, like metabolic diseases, oncology,<br />
immunology, endocrinology, and more.<br />
AG&M Grants <strong>2018</strong><br />
The AG&M innovation grant allows me…<br />
… to develop new analytical methods to understand dynamics in metabolism. The research technician Bauke<br />
Schomakers, who is funded by the AG&M innovation grant, is currently working on the development of tracerbased<br />
metabolomics (fluxomics) in which it should be possible to measure dynamics in metabolism using stable<br />
labeled isotope tracers. With unlabeled metabolomics methods we only measure static metabolism at a certain<br />
timepoint. With fluxomics we are able to trace metabolites through certain pathways in metabolism. This<br />
technique is already applied in several projects and will be better optimized in the future to be able to measure the<br />
severity of several metabolic diseases. This will help in predicting disease severity outcomes and will aid work on<br />
personalized treatments.<br />
More recently, we were awarded grants from the Velux Stiftung and NWO that allowed us to acquire state-of-art<br />
high resolution mass spectrometers. These provided a significant boost to the development of metabolomics and<br />
fluxomics analysis by adding extra mass spectrometry capacity and improved mass spectrometry techniques.<br />
Bauke Schomakers and Michel van Weeghel<br />
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