Turkish Journal of Hematology Volume: 35 - Issue: 4

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LETTERS TO THE EDITOR Turk J Hematol 2018;35:300-314SCT because early therapy for a possible Demodex infestationwould prevent the progression of GVHD.Keywords: Demodex folliculitis, Acute graft-versus-host disease,Post-transplantationAnahtar Sözcükler: Demodeks follikülit, Akut graft versus hosthastalığı, Nakil sonrasıInformed Consent: Informed consent was received from thepatient.Figure 1. A) Demodex mite; B) Civatte body in the follicularepithelium containing Demodexand lymphocyte exocytosis; C)Civatte body in the epithelium far from the follicle; D) diffusebasal vacuolization in epidermis (periodic acid-schiff staining,magnification 40 x ) (159x119 mm; 72x72 DPI).were eruptions on the cheek, forehead, and jaw regions,which can be distinguished in both acute GVHD and Demodexfolliculitis. However, the development of palmar erythema ofthe upper extremities is not a feature of demodicidosis. Asconfirmed by pathological examination, there were findingsof both acute GVHD (presence of Civatte bodies, lymphocyteexocytosis, diffuse basal vacuolization in the epidermis) anddemodicidosis (presence of Demodex folliculorum).It should not be forgotten that GVHD may be associated withdemodicidosis and Demodex infestation should be rememberedin the differential diagnosis of eruptions in patients withhematological malignancies receiving chemotherapy and afterSCT. For this reason, when the diagnosis of acute GVHD isambiguous, an early skin biopsy has to be done after allogeneicConflict of Interest: The authors of this paper have no conflictsof interest, including specific financial interests, relationships,and/or affiliations relevant to the subject matter or materialsincluded.References1. Bearman SI, Applebaum FR, Buckner CD, Petersen FB, Fisher LD, CliftRA,Thomas ED. Regimen-related toxicity in patients undergoing bonemarrow transplantation. J Clin Oncol 1988;6:1562-1568.2. Hillen U, Häusermann P, Massi D, Janin A, Wolff D, Lawitschka A, GreinixH, Meyer R, Ziemer M. Consensus on performing skin biopsies, laboratoryworkup, evaluation of tissue samples and reporting of the results in patientswith suspected cutaneous graft-versus-host disease. J Eur Acad DermatolVenereol 2015;29:948-954.3. Cotliar J, Frankfurt O. Demodex folliculitis mimicking acute graft-vs-hostdisease. JAMA Dermatol 2013;149:1407-14094. Lotze C, Krüger WH, Kiefer T, Swensson O, Herbst EW, Schüler F, BusemannC, Dölken G. Facial rash mimicking cutaneous acute graft-versus-hostdisease after allogeneic stem cell transplantation for osteomyelofibrosis:was Demodex the culprit? Bone Marrow Transplant 2006;37:711-712.5. Aisa Y, Mori T, Tanikawa A, Takae Y, Kato J, Ikeda Y, Okamoto S. Demodicidosisas a cause of facial eruption developing early after allogeneic hematopoieticstem cell transplantation. Transplant Int 2008;21:1192-1193.6. Román-Curto C, Meseguer-Yebra C, Cañueto J, Fraile-Alonso C, Santos-BrizA, Vázquez L, Fernández-López E. Demodicidosis stimulating acute graftversus-hostdisease after allogeneic stem cell transplantation in one patientwith acute lymphoblastic leukemia. Transpl Infect Dis 2012;14:387-390.©Copyright 2018 by Turkish Society of HematologyTurkish Journal of Hematology, Published by Galenos Publishing HouseAddress for Correspondence/Yazışma Adresi: Pelin AYTAN, M.D.,Başkent University Faculty of Medicine, Training and Research Hospital, Bone Marrow and Stem Cell TransplantationCenter, Clinic of Hematology, Adana, TurkeyPhone : +90 322 327 27 27 / 2028 E-mail: drpelinaytan@gmail.com ORCID-ID: orcid.org/0000-0002-4213-1565Received/Geliş tarihi: February 06, 2018Accepted/Kabul tarihi: July 02, 2018DOI: 10.4274/tjh.2018.0057314
Advisory Board of This Issue (December 2018)Ab Latif Wani, IndiaAldo Tomasi, ItalyAslı Çakır, TurkeyBengü Akay, TurkeyBilgül Mete, TurkeyBurhan Ferhanoğlu, TurkeyCan Boğa, TurkeyCem Akkuş, USADaniel Wolff, GermanyDemet Cansaran Duman, TurkeyEbru Koca, TurkeyEmin Kaya, TurkeyEvangelos Terpos, GreeceFrancesca Floredda, USAGünhan Gürman, TurkeyHamdi Akan, TurkeyIrene de Lazaro, USAKarl Welte, GermanyMaria Gamaletsou, United KingdomMaria Jose Teles, PortugalMarije Bartels, NetherlandsMeral Beksaç, TurkeyMustafa Pehlivan, TurkeyMutlu Arat, TurkeyMüfide Okay, TurkeyMünci Yağcı, TurkeyMyungshin Kim, KoreaNaci Tiftik, TurkeyNilay Şen Türk, TurkeyNükhet Tüzüner, TurkeyOktay Bilgir, TurkeyOlga Meltem Akay, TurkeyÖnder Arslan, TurkeyÖzgür Mehtap, TurkeyPervin Topçuoğlu, TurkeyPiero Farruggia, ItalyRauf Haznedar, TurkeySelami Koçak Toprak, TurkeySemra Paydaş, TurkeySinem Civriz Bozdağ, TurkeyTahsin Özpolat, USATuğçe Balcı Okcanoğlu, TurkeyYusuf Baran, TurkeyZeynep Karakaş, TurkeyZühre Kaya, Turkey
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RESEARCH ARTICLEDOI: 10.4274/tjh.20
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Turkish Journal of Hematology Volume: 35 - Issue: 4

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