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2020 Spring/Summer Highlights of Hope

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HIGHLIGHTS OF HOPE | SPRING/SUMMER ’20 ISSUE<br />

2 10 Research Trends 4 MSA Clinical Trial 6 Tackling a Rare Disease 8–9 VAI Employee Spotlights 10–11 Graduate School Spotlights<br />

12 San Juan Diego Academy Pilots Blue Apple 13 VAI <strong>Summer</strong> Camps 14 Events 22 Event Sponsors 24 PC Lunch & Learn<br />

26 Donor Spotlight: Dr. Juan Olivarez 28 Fundraising with VAI 29 Employee Donor Spotlight: Kay Koo 30 Memorials & Tributes


RESEARCH<br />

10 RESEARCH TRENDS WE’RE EXCITED TO<br />

WATCH IN THE NEXT DECADE<br />

With a new decade comes a new world <strong>of</strong> possibility, and<br />

innovation waiting to be unleashed in labs at Van Andel<br />

Institute and across the globe. As we take our first steps into the<br />

<strong>2020</strong>s, here are 10 promising research trends to keep an eye on<br />

now and in the coming years.<br />

Our understanding <strong>of</strong> Parkinson’s disease will continue to<br />

evolve, spurring new research and breakthroughs<br />

Parkinson’s disease has long been considered a movement-related<br />

disorder that originates in the brain. Recent research, however,<br />

suggests that Parkinson’s disease might represent a group <strong>of</strong><br />

closely related disorders. While they share key clinical features,<br />

they may have roots in different anatomical locations, such as the<br />

gut and nose. Even if the anatomical starting points differ, there is<br />

evidence that cell metabolism, inflammation and poor handling <strong>of</strong><br />

certain proteins are common features. In the coming years, these<br />

insights could lead to the development <strong>of</strong> new therapies to slow or<br />

stop its progression.<br />

Breakthroughs in common diseases like Parkinson’s, dementia<br />

with Lewy bodies and Alzheimer’s might help us better<br />

understand rare disorders<br />

It’s become increasingly clear that an improved understanding <strong>of</strong><br />

one disease may provide new insights into another. For rare and<br />

understudied diseases like multiple system atrophy, this provides<br />

a particularly important opportunity to gain the insight required to<br />

develop new diagnostics and treatments.<br />

Inflammation will increasingly be linked to disease — and give<br />

rise to new treatments<br />

Inflammation is a normal part <strong>of</strong> the immune system, responsible<br />

for marshalling resources to the site <strong>of</strong> a wound, infection or<br />

disease (like cancer) to help the body fight back. When inflammation<br />

remains longer than needed, it can cause or contribute to a host <strong>of</strong><br />

health problems. Researchers are hard at work sorting out exactly<br />

how and why this happens, which could be the findings that serve<br />

as the foundation for new therapies for cancer, neurodegenerative<br />

diseases, depression and many others.<br />

Understanding how the body processes, uses and stores<br />

energy will be critically important<br />

Metabolism powers every aspect <strong>of</strong> the human body, from<br />

keeping the immune system running to ensuring our hearts have<br />

enough energy to beat. We’ve known for some time that metabolic<br />

dysfunction plays a central role in diseases like diabetes and even<br />

in cancer, thanks to malignant cells’ voracious appetites for energy.<br />

But new breakthroughs also have linked issues with metabolism<br />

to neurodegenerative diseases like Parkinson’s and Alzheimer’s,<br />

among others. As we better understand our bodies’ incredibly<br />

complex web <strong>of</strong> metabolic processes, it’s likely that we will continue<br />

to find metabolism at the center <strong>of</strong> many disorders — and many<br />

future treatments.<br />

Cancer treatment will harness combinations <strong>of</strong> medications<br />

designed to give cancer a one-two punch<br />

We now know that cancer comprises more than 100 different<br />

diseases, each with its own litany <strong>of</strong> subtypes (for example, breast<br />

cancers can be defined based on the presence or absence <strong>of</strong><br />

certain molecular receptors). This expansive diversity means that<br />

there is likely no silver bullet cure. Instead, we can expect to see<br />

more combination therapies that utilize multiple medications<br />

whose effects complement or enhance each other’s ability to fight<br />

cancers. A prime example is pairing an immunotherapy drug,<br />

which bolsters the body’s natural defenses against cancer, with<br />

an epigenetic drug that makes cancer cells more recognizable,<br />

more susceptible to immune attack, and is thought to reinvigorate<br />

exhausted immune cells and get them back in the fight.<br />

We will better understand how the health and diet <strong>of</strong> one<br />

generation can affect the next<br />

Can a parent’s diet, experiences and lifestyle impact their children?<br />

Or subsequent generations? Mounting evidence suggests that<br />

nutrition does indeed have a ripple effect across generations, even<br />

altering individuals’ predisposition to disease. Efforts are underway<br />

to better understand how nutrition and other environmental<br />

factors reprogram the genome and epigenome, and how this<br />

information traverses generations. The goal: developing ways<br />

to prevent and treat diseases including diabetes, cancer, and<br />

Parkinson’s, and to protect our children from the unwanted<br />

consequences <strong>of</strong> our own lifestyles.<br />

We will see the translation <strong>of</strong> structural findings into<br />

actionable therapies<br />

Structural biology seeks to determine the shape and architecture<br />

<strong>of</strong> life’s smallest building blocks, such as proteins. These efforts<br />

are vitally important, helping us understand in intricate chemical<br />

detail how the body works and laying the earliest foundations for<br />

new medications. In the past five years, there has been a boom<br />

in structural research, based on technological advances in cryoelectron<br />

microscopy (cryo-EM), a technique that helps scientists<br />

view molecules down to the atomic level. In the next decade, we will<br />

continue to build on these foundational discoveries, which could<br />

give rise to new treatments.<br />

2 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


We’ll learn more about microenvironments and microbiomes<br />

and their role in cancer and other diseases<br />

In many ways, the future will be “micro.” Our technology is<br />

miniaturizing; we are able to study the tiniest components <strong>of</strong><br />

life in ways never before possible and scientists are increasingly<br />

understanding the importance and diversity <strong>of</strong> microenvironments,<br />

the mini ecosystems that exist throughout the body. In cancer, the<br />

microenvironment is the area immediately surrounding a tumor,<br />

which can comprise blood vessels, immune cells and structural<br />

cells, among others. These areas <strong>of</strong>fer windows into how specific<br />

cancers grow and proliferate, and may even <strong>of</strong>fer new solutions<br />

for stopping them. We’re also learning more about the role <strong>of</strong><br />

microbiomes, the host <strong>of</strong> microscopic organisms such as bacteria<br />

that inhabit specific areas <strong>of</strong> the body like the gut. For example,<br />

researchers who are sleuthing out the links between the gut and<br />

Parkinson’s disease are taking a look at the gut microbiome as a<br />

possible factor in disease onset.<br />

Technology will spur even more innovation<br />

Editing genes using CRISPR. Determining molecular structures<br />

with high-powered cryo-EM. Decoding the genome through nextgeneration<br />

sequencing. The advent <strong>of</strong> these powerful technological<br />

tools, paired with increasingly robust computational capabilities,<br />

have revolutionized how we study health and disease, and already<br />

have contributed to critical biomedical breakthroughs. With<br />

technology continually advancing, we can only expect the innovation<br />

to continue in years to come.<br />

Big Data will continue to yield new insights<br />

Big Data refers to the massive amounts <strong>of</strong> information generated<br />

by certain types <strong>of</strong> research, such as genomics. With technology<br />

improving every day, the amount <strong>of</strong> data being churned out will only<br />

continue to balloon, presenting opportunities and challenges to<br />

scientists working to get to the root <strong>of</strong> disease. By closely analyzing<br />

large datasets (a monumental task itself), scientists can look for<br />

patterns linked to disease. A prime example is The Cancer Genome<br />

Atlas, a National Institutes <strong>of</strong> Health-led effort that molecularly<br />

mapped 33 different types <strong>of</strong> cancer. These highly detailed and vast<br />

datasets helped identify important variations in cancer types and<br />

subtypes that may form the foundation <strong>of</strong> new targeted therapies.<br />

To read more about Van Andel Institute’s research in these areas, visit<br />

vai.org/10-trends-<strong>2020</strong>s.<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 3


RESEARCH<br />

CAN A DIABETES DRUG SLOW OR STOP A<br />

DEVASTATING NEURODEGENERATIVE DISEASE?<br />

A NEW CLINICAL TRIAL GIVES HOPE TO PEOPLE WITH MULTIPLE SYSTEM ATROPHY<br />

Philip Fortier is on a mission: to find a cure for multiple system<br />

atrophy, a devastating neurodegenerative disease that lacks<br />

an effective way to halt progression.<br />

For him, it’s deeply personal. His brother, Joe, battled MSA for three<br />

years before passing away in 2013. Now, the organization the<br />

Fortier family founded — Defeat MSA Alliance — has teamed up<br />

with Van Andel Institute and others to support a groundbreaking<br />

clinical trial to see if a common diabetes drug called exenatide may<br />

also impede MSA’s rapid course.<br />

“There are a great many people around the world suffering from<br />

MSA and there are no drugs known to slow it down,” Fortier said.<br />

“Anything we can do to help research — to find a drug that can be<br />

repurposed to help people — is something we should and must<br />

do.”<br />

A tough foe<br />

MSA is a quick and cruel disease. Over the course <strong>of</strong> five to<br />

10 years, it ravages the body, shutting down the vital systems<br />

necessary to keep a person healthy and functioning like the ability<br />

to move, to regulate heart rate and to digest food. Between 15,000<br />

and 50,000 people in the U.S. have MSA. The exact number is<br />

tough to pin down because MSA is notoriously difficult to diagnose,<br />

particularly in its early stages when it <strong>of</strong>ten is mistaken for<br />

Parkinson’s disease.<br />

In fact, like Parkinson’s, many scientists also believe MSA is linked to<br />

a buildup <strong>of</strong> abnormal proteins called alpha-synuclein, which clog<br />

critical cells and cause them to die. In MSA, these cells are the glia,<br />

which support and protect the brain’s nerve cells.<br />

“We now know that MSA, Parkinson’s and another related disorder,<br />

Lewy body dementia, are all linked by alpha-synuclein,” Fortier<br />

said. “That has given us new hope that, with more research, we can<br />

possibly find something that gives people with MSA more years<br />

with fewer symptoms.”<br />

New hope<br />

The pilot trial is helmed by Pr<strong>of</strong>. Thomas Foltynie in collaboration<br />

with colleagues at University College London Queen Square<br />

Institute <strong>of</strong> Neurology and the UCLH National Hospital for<br />

Neurology and Neurosurgery in London. Two previous small<br />

clinical trials by Foltynie’s group have shown that exenatide is<br />

well-tolerated in patients and may slow Parkinson’s progression.<br />

Additionally, lab data in models <strong>of</strong> MSA and post-mortem data from<br />

the brains <strong>of</strong> people who had MSA indicate that exenatide may<br />

have positive effects.<br />

“There are a great many people around the<br />

world suffering from MSA and there are no<br />

drugs known to slow it down. Anything we<br />

can do to help research — to find a drug<br />

that can be repurposed to help people — is<br />

something we should and must do.”<br />

— PHILIP FORTIER<br />

The approach — repurposing a medication developed for one<br />

disease to treat another — is an innovative way to maximize<br />

scarce resources and shave <strong>of</strong>f precious time in the search for<br />

new treatments, said Dr. Patrik Brundin, director <strong>of</strong> VAI’s Center for<br />

Neurodegenerative Science and a Parkinson’s expert. Brundin’s lab<br />

also studies the origins <strong>of</strong> MSA and is investigating potential new<br />

therapies, such as another drug developed to treat diabetes as a<br />

possible treatment for Parkinson’s and MSA.<br />

“Although they look different on the surface, many diseases are<br />

linked to similar biological pathways. That’s why a diabetes drug has<br />

potential to treat neurological disorders like MSA and Parkinson’s,”<br />

Brundin said. “Repurposing is another tool for us to work quickly<br />

toward life-changing breakthroughs.”<br />

Fortier sees the trial as a bold new step forward in MSA research,<br />

bolstered by a collaborative group <strong>of</strong> organizations that have united<br />

to take on a particularly challenging adversary.<br />

4 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAI CHIEF DEVELOPMENT OFFICER BRETT HOLLEMAN, PHILIP FORTIER,<br />

DR. PATRIK BRUNDIN & VAI POSTDOCTORAL FELLOW DR. WOUTER PEELAERTS<br />

“If we are going to be successful, we need more research and<br />

we need to bring together people from across the scientific<br />

community,” Fortier said. “It’s a calling — to love and care for one<br />

another and do our best to help people with MSA.”<br />

The study is funded by the John Black Charitable Foundation in the<br />

U.K. and Van Andel Institute and the Defeat MSA Alliance in the U.S. The<br />

study is supported by the MSA Trust (U.K.).<br />

ABOUT MULTIPLE SYSTEM ATROPHY<br />

• Between 15,000 and 50,000 people in the<br />

U.S. have MSA<br />

• Symptoms most frequently appear after age 50<br />

• Early symptoms are frequently difficult to distinguish<br />

from Parkinson’s disease and include tremor, rigidity,<br />

slowed movement and impaired speech<br />

• Like Parkinson’s, MSA is considered to be a<br />

“synucleinopathy,” a disease marked by buildup<br />

<strong>of</strong> the protein alpha-synuclein.<br />

Source: National Institute <strong>of</strong> Neurological<br />

Disorders and Stroke<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 5


RESEARCH<br />

HOW BIG DATA AND COLLABORATION IS<br />

REDEFINING A RARE FORM OF DEMENTIA<br />

Van Andel Institute’s Dr. Rita Guerreiro and Dr. José Brás<br />

have teamed up with more than 100 other scientists from<br />

around the world to take on frontotemporal dementia, a<br />

rare disease that currently has no cure and no treatment<br />

that slows progression.<br />

In late 2019, the group led by Dr. Jonathan Rohrer at University<br />

College London published a wide-ranging study in The Lancet<br />

Neurology that provides new insight into FTD that could one<br />

day shape future treatments. Here’s a quick primer on FTD and<br />

breakdown <strong>of</strong> their findings.<br />

Frontotemporal dementia is rare and tough to define — and<br />

that makes it hard to study<br />

For more than a century, the exact name and definition <strong>of</strong><br />

frontotemporal dementia has been in flux. It is best described as<br />

a syndrome — a set <strong>of</strong> symptoms that <strong>of</strong>ten occur together. While<br />

the exact parameters <strong>of</strong> what constitutes FTD will likely evolve as<br />

we learn more, typical features <strong>of</strong> the disease include progressive<br />

shrinking <strong>of</strong> the frontal and anterior temporal lobes <strong>of</strong> the brain;<br />

that is, the brain’s front and bottom regions.<br />

Other FTD symptoms fall into two categories:<br />

• Behavioral changes, such as impulsive or listless behavior,<br />

inappropriate social behaviors, repetitive or compulsive<br />

behaviors, and agitation.<br />

• Difficulties with language, such as problems comprehending<br />

speech or with speaking. Often, these symptoms occur<br />

alongside behavioral symptoms.<br />

About one-third <strong>of</strong> FTD cases are genetic, meaning the disease can<br />

be directly linked to changes, or mutations, in specific genes.<br />

When it comes to rare diseases, collaboration is critical<br />

Rare diseases like FTD can be tough to study due in large part to<br />

their nature. There <strong>of</strong>ten simply aren’t enough cases from which to<br />

gather sufficient data. Moreover, while FTD is a rare disease, FTD<br />

caused by DNA mutations is even rarer.<br />

To establish what is typical for each mutation or for each gene,<br />

scientists must have enough cases with the same mutation or<br />

mutations in the same gene. This is only achievable by leveraging<br />

the collective power <strong>of</strong> research centers around the world. Each<br />

<strong>of</strong> these centers may only have a handful <strong>of</strong> cases but, when<br />

analyzed all together, scientists can start seeing patterns that<br />

would have been impossible to identify in the individual cohorts<br />

from each center.<br />

In this study, the team was able to compare data from 3,403<br />

individuals representing 1,492 families — far more than would be<br />

accessible at any one center. The result is a powerful overview <strong>of</strong><br />

genetic mutations that contribute to age <strong>of</strong> symptom onset, age <strong>of</strong><br />

death and length <strong>of</strong> disease in people with FTD.<br />

The findings lay an important foundation for future research<br />

and future treatment<br />

The study focused on the three genes most frequently mutated in<br />

FTD: MAPT, GRN and C9orf72. Here are a few examples from their<br />

findings:<br />

• GRN mutations were more likely to affect women than men.<br />

• People with MAPT mutations tended to be younger at symptom<br />

onset and at death.<br />

• People with C9orf72 mutations had the shortest disease<br />

duration, on average.<br />

Rare diseases like FTD can be<br />

tough to study due in large part<br />

to their nature. There <strong>of</strong>ten<br />

simply aren’t enough cases<br />

from which to gather sufficient<br />

data. Moreover, while FTD is a<br />

rare disease, FTD caused by DNA<br />

mutations is even rarer.<br />

Overall, the team was able to better characterize what is typical for<br />

rare mutations. This information is particularly important for people<br />

and families living with these mutations, for clinicians managing FTD<br />

and for drug developers assessing progression <strong>of</strong> disease in clinical<br />

trials.<br />

Additionally, a large-scale, Big Data study such as this allows<br />

scientists to better define disease subtypes by country and,<br />

ultimately, can move the field one step closer to precision medicine.<br />

6 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


DR. JOSÉ BRÁS & DR. RITA GUERREIRO<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 7


RESEARCH<br />

DAN ROGERS — NEW THERAPIES, ONE TRIAL AT A TIME<br />

All new therapies for diseases like cancer and Parkinson’s<br />

began in a lab — the culmination <strong>of</strong> years <strong>of</strong> research,<br />

scientific testing and rigorous clinical trials.<br />

These trials, which evaluate the safety and effectiveness <strong>of</strong> potential<br />

new treatments in real people, are the conduit that translate<br />

discoveries from the lab to a point where they can benefit patients.<br />

For more than five years, Dan Rogers, clinical research manager<br />

at Van Andel Institute, has helped organize and manage the<br />

Van Andel Institute–Stand Up To Cancer Epigenetics Dream<br />

Team, a collaborative effort that brings together leading scientists,<br />

physicians, philanthropic organizations and companies to improve<br />

the standard <strong>of</strong> cancer care. Along with a small but incredibly<br />

talented team <strong>of</strong> experts, Rogers helps the team to propel the<br />

discoveries made in labs into clinical testing — a critical step to<br />

getting new therapies to the patients who need them most.<br />

“When you hear David Van Andel, VAI’s<br />

chairman and CEO, say there are patients<br />

out there right now who are counting on<br />

us to come up with better treatments and<br />

diagnostics, it resonates with me the<br />

urgency <strong>of</strong> our mission.”<br />

— DAN ROGERS<br />

“My dad passed away from cancer in 2016 and was fortunate to<br />

live a long and quality life — even after diagnosis,” Rogers said. “I<br />

<strong>of</strong>ten think about how the work I am involved in now in advancing<br />

better treatment options for cancer patients have and will have an<br />

impact on people like my dad — extending their lives and giving<br />

them more time with their loved ones. When you hear David<br />

Van Andel, VAI’s chairman and CEO, say there are patients out<br />

there right now who are counting on us to come up with better<br />

treatments and diagnostics, it resonates with me the urgency <strong>of</strong><br />

our mission.”<br />

Rogers grew up in a family surrounded by medicine, science and<br />

the concept <strong>of</strong> service. His father worked for many years as an<br />

emergency room physician, which gave Rogers an early insight into<br />

the world <strong>of</strong> patient care.<br />

“As any typical young person, I resisted working in the family<br />

business — medicine — for quite a while. But, after working as an<br />

emergency room tech as a summer job in college, I developed an<br />

understanding <strong>of</strong> the importance <strong>of</strong> helping those in need and<br />

DAN ROGERS<br />

I was hooked,” Rogers said. “Now, I have this great opportunity<br />

to work for an Institute that can benefit human health, and as a<br />

member <strong>of</strong> the team I can play a role in clinical trials that bring<br />

new therapies to patients across the U.S. and the world. And<br />

knowing that is really gratifying and humbling.”<br />

8 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


BRYN EAGLESON — ONE OF THE<br />

INSTITUTE’S ORIGINAL RECRUITS<br />

When Van Andel Institute’s founding<br />

director <strong>of</strong> research, Dr. George<br />

Vande Woude, started the Institute’s<br />

research program in 1999, he recruited<br />

bright, young scientists and experts<br />

to help him build something truly<br />

unique. One <strong>of</strong> those recruits was Bryn<br />

Eagleson. A director in the Institute’s Core<br />

Technologies and Services, her work directly<br />

supports scientists as they uncover new<br />

diagnostics and treatments for cancer,<br />

neurodegenerative disorders and many<br />

other diseases.<br />

Motivated by the Institute’s mission to<br />

benefit human health for current and<br />

future generations, and its collaborative,<br />

innovative work environment, Eagleson has<br />

made VAI her pr<strong>of</strong>essional home for more<br />

than 20 years. After two decades <strong>of</strong> hard<br />

work, she now understands the role her<br />

work has played in helping shape VAI into<br />

a global epicenter for biomedical research<br />

and education. With no plans to slow down,<br />

Eagleson looks forward to serving the<br />

Institute’s mission until she retires.<br />

“My hope is that all <strong>of</strong> this cutting-edge<br />

research can soon become translated into<br />

new ways to help people in the clinic, and<br />

that our work can have a lasting benefit to<br />

human health,” she said. “It’s been amazing<br />

to build something from the beginning and<br />

to know my work has contributed to this<br />

incredible research. It is truly something I<br />

am so proud to be a part <strong>of</strong>.”<br />

BRYN EAGLESON<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 9


RESEARCH<br />

ALFREDO REYES OLIVERAS<br />

FINDS WORLD OF POSSIBILITIES<br />

AT VAI GRADUATE SCHOOL<br />

Two years before Alfredo Reyes Oliveras came to Van Andel<br />

Institute Graduate School, he survived a hurricane.<br />

Reyes Oliveras was at home with family when Hurricane Maria<br />

struck Puerto Rico in September 2017. He and his family made it<br />

through, but the deadly Maria caused extreme damage and left<br />

millions without power for months.<br />

“I woke up during the night to get a glass <strong>of</strong> water and looked<br />

through the window. You could see trees falling,” Reyes Oliveras<br />

said. “The house in front <strong>of</strong> ours disappeared.”<br />

Despite the damage, Reyes Oliveras was able to return to his<br />

studies at University <strong>of</strong> Puerto Rico, Mayagüez Campus, relatively<br />

soon after; the university had escaped the brunt <strong>of</strong> the storm.<br />

He went on to earn two bachelor’s degrees: one in chemistry and<br />

another in molecular biology.<br />

Reyes Oliveras is part <strong>of</strong> VAI’s largest and most international<br />

Graduate School cohort to date. He learned <strong>of</strong> the Graduate<br />

School while researching programs in molecular biology.<br />

The Graduate School stood out from his other two considerations,<br />

Cornell University and University <strong>of</strong> Miami, because he viewed<br />

the Institute’s small size as an asset. “The Institute <strong>of</strong>fers a more<br />

welcoming experience,” Reyes Oliveras said. “You can know<br />

everybody here, and I really like that. You can make connections<br />

easily.”<br />

Reyes Oliveras is interested in further exploring cancer research<br />

at the Institute. His curiosity in the field was piqued during an<br />

undergraduate internship at University <strong>of</strong> Miami, where he studied<br />

pancreatic cancer.<br />

Though he leans toward pursuing cancer research, Reyes Oliveras<br />

had the opportunity to work on immune system research during a<br />

laboratory rotation with Dr. Connie Krawczyk his first semester. The<br />

research he saw impressed him and gave him something to think<br />

about in regard to his future track. Under the Graduate School’s<br />

curriculum, he’ll choose a thesis and select a research adviser in<br />

spring <strong>2020</strong> — his second semester.<br />

Just one semester in, Reyes Oliveras is already excited about the<br />

possibilities ahead.<br />

“The research at VAI is great,” he said, “and so far, I’ve only been<br />

exposed to a little bit <strong>of</strong> the science that’s happening here.”<br />

ALFREDO REYES OLIVERAS<br />

GRADUATE SCHOOL<br />

BY THE NUMBERS<br />

5.3 years average time to Ph.D.<br />

3 seven-week laboratory rotations during<br />

first two semesters<br />

3 years <strong>of</strong> doctoral candidate thesis<br />

research in a faculty mentor’s lab<br />

68% Ph.D. graduation rate<br />

75% total graduation rate (Ph.D. and M.D.)<br />

10 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


GRADUATE SCHOOL ‘A STEP ABOVE<br />

ALL THE OTHER PROGRAMS’ FOR<br />

DR. NIKKI THELLMAN<br />

For Dr. Nikki Thellman, earning a degree in veterinary<br />

medicine wasn’t enough.<br />

A self-described lifelong learner, she wanted to go beyond what<br />

she studied in vet school and tackle pressing problems in the clinic<br />

from a research perspective. “I was already a pr<strong>of</strong>essional with<br />

clinical experience and a vast understanding <strong>of</strong> disease diagnosis<br />

and treatment,” Thellman said. “What was missing was a deep<br />

understanding <strong>of</strong> the underlying mechanisms for disease and the<br />

scientific training to tackle unmet medical needs.”<br />

After four years <strong>of</strong> practicing veterinary medicine, Thellman<br />

researched doctoral programs. At a graduate school fair, she<br />

happened upon a booth for Van Andel Institute Graduate School.<br />

Intrigued by its mission and problem-based curriculum, she<br />

applied and was accepted.<br />

“I felt the Graduate School was unique and was truly a step above<br />

all the other programs,” Thellman said. “I would be building upon<br />

my skill sets and not just be another student number.”<br />

At the Institute, she joined the lab <strong>of</strong> Graduate School Dean<br />

Dr. Steven Triezenberg, whose research has greatly expanded<br />

understanding <strong>of</strong> how viruses “wake up” after lying dormant.<br />

Under Triezenberg’s mentorship, Thellman began studying herpes<br />

simplex virus, a common pathogen whose two types — herpes<br />

simplex virus type 1 and herpes simplex virus type 2 — collectively<br />

affect more than 4 billion people worldwide. Her task? To develop<br />

a laboratory tool growing sensory neurons in order to study the<br />

molecular and genetic factors that allow the virus to establish itself<br />

in a host, fall dormant and later reactivate.<br />

Thellman successfully defended her dissertation in 2017. She<br />

then spent two years as a clinical development manager at<br />

Zoetis, the largest animal health company in the world, running<br />

companion animal clinical trials for novel therapeutics. She recently<br />

transitioned to a senior scientist role there where she continues to<br />

blend her passions for veterinary medicine and scientific discovery<br />

to make a tangible impact on disease management.<br />

“Van Andel Institute Graduate School trained me to think like a<br />

scientist,” she said. “Everyone knows you and is eager to make your<br />

education experience a success.”<br />

For more information on Van Andel Institute Graduate School, visit<br />

vaigs.vai.org.<br />

DR. NIKKI THELLMAN<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 11


EDUCATION<br />

BLUE APPLE BRINGS PROJECT-BASED LEARNING TO LIFE<br />

The fifth-grade students at San Juan Diego Academy faced a<br />

choice: should they protect Earth’s environment or explore<br />

Mars as a potential home?<br />

The fifth-grade students at San Juan Diego Academy faced a<br />

choice: should they protect Earth’s environment or explore Mars<br />

as a potential home?<br />

The students were among the first to pilot a new program called<br />

Blue Apple, created by Van Andel Institute for Education to<br />

increase students’ engagement and help teachers who want to<br />

make a significant difference in their students’ lives. Blue Apple<br />

provides teachers with project plans and supplies, connections to<br />

real-world experts, cross-curricular content, and the opportunity<br />

to collaborate with other classrooms. The Institute also makes<br />

members <strong>of</strong> its staff available as project coaches.<br />

“Working with VAI is just something special for us, and we are<br />

really blessed,” said Christine Wright, a fifth-grade teacher at San<br />

Juan Diego Academy. “If the Institute did not work with us and<br />

give us these opportunities, there would be experiences our<br />

students would miss out on.”<br />

Wright’s students undertook Blue Apple’s “Dirty Truth” project,<br />

and learned the importance <strong>of</strong> protecting Earth’s environment<br />

and researched the potential <strong>of</strong> life on Mars. They studied soils<br />

and fertilizers to grow crops, and filmed commercials to raise<br />

money for their causes.<br />

The class divided into two teams — the Red Team for Mars, the<br />

Blue Team for Earth — researched each option, and then taped<br />

commercials urging people to donate for their causes. For the<br />

students — most <strong>of</strong> them the children <strong>of</strong> recent immigrants from<br />

Mexico, Central America and South America — the exercise was an<br />

engaging, cross-curricular exercise combining English language<br />

arts, math, science, social studies, and social-emotional learning.<br />

The Red Team raised $205 and donated it to Students for the<br />

Exploration and Development <strong>of</strong> Space. The Blue team raised $188<br />

and donated it to the Environmental Defense Fund.<br />

Blue Apple, which launched in 2019, has been adopted by more<br />

than 200 schools throughout the Midwest and beyond. Teachers<br />

who have used Blue Apple projects have been very happy with how<br />

their students became engaged and enthusiastic about learning.<br />

“It’s always been a part <strong>of</strong> our mission to impact education on a<br />

national scale. We think Blue Apple is a productive way to do it.<br />

The project really is built around the idea that engagement leads<br />

to achievement,” said Terra Tarango, VAI’s chief education <strong>of</strong>ficer.<br />

“We’re really pleased that 100 percent <strong>of</strong> the teachers said it<br />

increased critical and creative thinking among their students.”<br />

For more information about Blue Apple, visit blueappleteacher.org.<br />

SAN JUAN DIEGO ACADEMY STUDENTS<br />

ENGAGING WITH BLUE APPLE<br />

12 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAI SUMMER CAMPS<br />

HOW VAI SUMMER CAMPS NURTURE A FAMILY’S LOVE OF LEARNING<br />

Ceci Kovarik, a lively 9-year-old, recently took a trip to Mars.<br />

Ceci attended “Mission to Mars,” one <strong>of</strong> VAI’s summer camps,<br />

where she was able to explore the science, engineering and<br />

technology needed to complete a trip to another planet.<br />

Along with students from West Michigan, Ceci made new friends,<br />

developed an understanding <strong>of</strong> scientific concepts and embraced<br />

her boundless curiosity.<br />

Ceci’s mother, Joanna, is a Polish immigrant who met her husband,<br />

originally from the Czech Republic, on a flight from Prague to<br />

Chicago. After they got married, the couple settled on the north<br />

side <strong>of</strong> Grand Rapids, where they are raising six children together.<br />

Kovarik believes that her children’s future and their success lies in<br />

the power <strong>of</strong> knowledge. “I understood that one <strong>of</strong> the best ways<br />

you can advance yourself in this country is through education, so I<br />

always encourage our kids to work hard and do the best they can,”<br />

Joanna said. Joanna learned about VAI’s educational programs from<br />

a teacher at their middle school, and the recommendation helped<br />

shape the trajectory <strong>of</strong> her children’s lives.<br />

“The Institute really opened up the kids’ horizons and enabled them<br />

to work with students from other schools who were also passionate<br />

about science and focused on learning,” Joanna said. “The kids<br />

involved in these programs are so empowered to learn, and the<br />

teachers really help them view what they are doing as important<br />

and valuable.”<br />

JOANNA, LUCIE & CECI KOVARIK<br />

Lucie Kovarik, a sophomore in high school with a passion for<br />

science, also participated in VAI’s summer camps. She enjoyed the<br />

opportunity to meet like-minded students and explore her interests<br />

so much that she has attended the camp for the past three years.<br />

“I am always looking for opportunities to learn, and I really love the<br />

diversity <strong>of</strong> science,” Lucie said. “When you’re a scientist, there’s just<br />

so much out there to explore.”<br />

Joanna is grateful her children were able to participate in VAI’s<br />

education programs and hopes the Institute will continue to expand<br />

on education initiatives that have given her children such wonderful<br />

opportunities to experience the joy <strong>of</strong> learning, explore new<br />

interests and discover the world.<br />

“I credit Van Andel Institute for a lot <strong>of</strong> my kids’ success in school,”<br />

Joanna said. “It’s worth the commitment, and when you don’t have<br />

access to very many educational resources, a program like this<br />

really means a lot.”<br />

For information on Van Andel Institute’s student programs, visit<br />

vaei.org/student-programs.<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 13


EVENTS<br />

CURIOSITY HOUR<br />

Parents and children got the chance to rekindle their<br />

childhood during Curiosity Hour. Guests explored Van Andel<br />

Institute’s animal habitats, observed science demonstrations<br />

and engaged in hands-on science challenges. The family-focused<br />

event highlighted the many ways VAI is creating classrooms where<br />

curiosity, creativity and critical thinking thrive.<br />

(STARTING AT THE TOP LEFT, GOING CLOCKWISE) KIDS EXPERIMENT WITH FOSSILS AT THE CAN YOU DIG IT STATION;<br />

GUESTS COOL DOWN AT THE KONA ICE TRUCK; TOBY THE TORTOISE IN HER HABITAT; KIDS THINK LIKE ENGINEERS TO BUILD STABLE STRUCTURES;<br />

TESTING STRUCTURE DESIGNS AT THE SHAKE, SHAKE, SHAKE STATION<br />

14 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAI GOLF OUTING<br />

Golfers, donors and Van Andel Institute supporters gathered<br />

for a day <strong>of</strong> fundraising and fun during the Institute’s 12th<br />

annual VAI Golf Outing. Held at the beautiful Wuskowhan Players<br />

Club in West Olive, Michigan, guests enjoyed 18 holes on a beautiful<br />

course, lunch, and a dinner and awards presentation featuring<br />

special guest, hockey player and philanthropist Mike Knuble.<br />

Thank you to the Title Sponsor: The Veldheer, Long, Mackay &<br />

Bernecker Group <strong>of</strong> Merrill Lynch.<br />

(STARTING AT THE TOP LEFT, GOING CLOCKWISE) JACK DOLES, MIKE KNUBLE, DAVID VAN ANDEL & KYLE VAN ANDEL; THE TITLE SPONSOR GROUP<br />

ENJOYING THE DAY; CAROL VAN ANDEL & SUSAN SHAW; SPECIAL GUEST MIKE KNUBLE DISCUSSES THE IMPORTANCE OF THE INSTITUTE’S MISSION;<br />

THE SILENT AUCTION TABLE FEATURING A VARIETY OF RED WINGS MERCHANDISE SIGNED BY MIKE KNUBLE<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 15


EVENTS<br />

COUTURE FOR A CURE<br />

Fashionistas from across West Michigan joined Van Andel<br />

Institute for the 14th annual Couture for a Cure. This year’s<br />

event featured a fashion presentation by Leigh’s, and a runway<br />

show featuring designer Victoria Hayes Fall/Winter ’19 collection,<br />

as well as an Amway Artistry beauty lounge and strolling appetizers<br />

and cocktail stations.<br />

Thank you to the Presenting Sponsor: Leigh’s; and the Title<br />

Sponsor: Amway.<br />

(STARTING AT THE TOP LEFT, GOING CLOCKWISE) THE ARTISTRY BEAUTY LOUNGE FEATURING HAIR & MAKEUP TOUCHUPS; GUESTS ENJOY AN<br />

EXCLUSIVE LOOK AT VICTORIA HAYES’ FALL/WINTER ‘19 COLLECTION; CAROL VAN ANDEL SHARES THE INSTITUTE’S LASTEST RESEARCH UPDATES<br />

16 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


(STARTING AT THE TOP LEFT, GOING CLOCKWISE) AMWAY’S CANDACE MATTHEWS EMCEES THE EVENT; A MODEL WALKS THE RUNWAY; FEATURED<br />

DESIGNER VICTORIA HAYES, LEIGH’S OWNER REBECCA WIERDA, SCOTT WIERDA & LEIGH’S SALES MANAGER JOANNA HADJIYANIS;<br />

CAROL VAN ANDEL WITH JANE ZWIERS & YOUNG SUPPORTERS OF THE INSTITUTE FROM HOPE COLLEGE<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 17


EVENTS<br />

HOPE ON THE HILL GALA —<br />

A NIGHT IN WONDERLAND<br />

Hundreds <strong>of</strong> guests joined Alice, the Mad Hatter, Queen <strong>of</strong><br />

Hearts and Tweedle Dum and Dee for Van Andel Institute’s<br />

<strong>Hope</strong> on the Hill Gala — A Night in Wonderland. Guests enjoyed<br />

gourmet cuisine from Grand Rapids’ finest restaurants, artisan<br />

cocktails served on hand-carved bars <strong>of</strong> chiseled ice, an uproarious<br />

magical performance from Piff the Magic Dragon, and a dance<br />

party hosted by AB.<br />

Thank you to the Title Sponsor: Fifth Third Private Bank.<br />

(STARTING AT THE TOP LEFT, GOING CLOCKWISE) JEFFERY ROBERTS, CAROL VAN ANDEL & DAVID VAN ANDEL; GUESTS BID ON<br />

EXCITING PACKAGES AT THE SILENT AUCTION TABLE; PIFF THE MAGIC DRAGON ENTERTAINS THE AUDIENCE WITH HIS UNIQUE<br />

PERFORMANCE; CO-CHAIRS OF VAI’S JBOARD AMBASSADORS, CHAD BASSETT & RACHEL MRAZ;<br />

GUESTS DANCE THE NIGHT AWAY IN WONDERLAND<br />

18 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


(STARTING AT THE TOP LEFT, GOING CLOCKWISE) THE MAD HATTER ENTICING GUESTS TO A TEA PARTY; VAI’S DR. HEIDI LEMPRADL ENJOYS A<br />

CARD TRICK; THE CHESHIRE CAT SMILES AT GUESTS AS THEY CELEBRATE THE EVENING; WONDERFULLY DELICIOUS DESSERTS<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 19


EVENTS<br />

A CONVERSATION ABOUT<br />

METABOLISM AND NUTRITION—<br />

HOSTED BY CAROL VAN ANDEL<br />

A Conversation About Metabolism and Nurition — Hosted by<br />

Carol Van Andel placed a powerful spotlight on the Institute’s<br />

exciting new research into how metabolism and nutrition<br />

can play a role in diseases like cancer and Parkinson’s.<br />

During this informative event, VAI’s Dr. Russell Jones and Dr. Connie<br />

Krawczyk provided information on their research, and how these<br />

biological functions can both prevent and proliferate disease.<br />

The two esteemed scientists also answered questions from those<br />

in attendance.<br />

Thank you to the Title Sponsor: Howard Miller.<br />

(STARTING AT THE LEFT, GOING CLOCKWISE) DR. RUSSELL JONES, DR. CONNIE KRAWCZYK & WOOD TV’S MARANDA; CAROL VAN ANDEL<br />

HOSTING THE EVENT; GUESTS NETWORK BEFORE THE EVENT; VAI’S CHIEF SCIENTIFIC OFFICER DR. PETER A. JONES MINGLING WITH GUESTS<br />

20 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAI PUBLIC LECTURE: A FOCUS<br />

ON TRANSLATIONAL MEDICINE<br />

Taking scientific discoveries from the lab to the doctor’s <strong>of</strong>fice<br />

requires a complex system <strong>of</strong> testing and trials. Translational<br />

medicine is an important area <strong>of</strong> research which aims to better<br />

understand scientific discoveries that might be beneficial to human<br />

health. Guests attending A Focus on Translational Medicine learned<br />

how data from basic research and clinical trials is translated into new<br />

diagnostics and therapies that might one day benefit patients.<br />

Dr. Matt Steensma, a scientific investigator in the Institute’s Center<br />

for Skeletal Disease Research, and Dr. Stephen Baylin, co-leader <strong>of</strong><br />

the Van Andel Institute–Stand Up To Cancer Epigenetics Dream<br />

Team, both presented their work and answered questions during<br />

this research-focused event.<br />

VAI PUBLIC LECTURE: A FOCUS ON<br />

EDUCATION IN AMERICA<br />

Our world is changing rapidly — new technologies, access<br />

to information and the demands <strong>of</strong> the modern workforce<br />

present students and teachers with an impressive amount<br />

<strong>of</strong> challenges. Van Andel Institute’s chief education <strong>of</strong>ficer, Terra<br />

Tarango, presented the various ways the Institute is creating<br />

classrooms where students are prepared to meet the challenges<br />

<strong>of</strong> the 21st century during A Focus on Education in America. Guests<br />

learned about Common Core Standards, standards-based<br />

grading practices, project-based learning and new ways to create<br />

classrooms that are filled with engaged learners.<br />

(STARTING AT THE LEFT, GOING CLOCKWISE) BRETT HOLLEMAN, DR. MATT STEENSMA & DR. STEPHEN BAYLIN;<br />

TERRA TARANGO; GUESTS PARTICIPATE IN AN INTERACTIVE DISCUSSION<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 21


EVENTS<br />

THANK YOU TO OUR GENEROUS EVENT SPONSORS<br />

To learn more about sponsoring an event, contact Sarah Rollman at sarah.rollman@vai.org.<br />

VAI Golf Outing<br />

Dennis & Barbara Adama<br />

Applied Imaging<br />

Custer Inc.<br />

Erhardt Construction<br />

First National Bank<br />

Gallagher Insurance<br />

Grand Rapids Christian Schools<br />

Ben & Molly Hunting<br />

iHeart Media<br />

Life EMS Ambulance<br />

Macatawa Bank<br />

Making the Turn Against Parkinson’s<br />

Merrill Lynch — Veldheer, Long, Mackay &<br />

Bernecker Group<br />

Metro Health — University <strong>of</strong><br />

Michigan Health<br />

Midwest Capital Advisors, LLC<br />

Pine Rest<br />

Priority Health<br />

Regal Financial Group LLC.<br />

Rockford Construction<br />

John & Therese Rowerdink<br />

Secrest Wardle<br />

Summit Point Ro<strong>of</strong>ing<br />

The John Dykema & Michele Maly-Dykema<br />

Family Foundation<br />

The Sharpe Collection<br />

Thomas & Mary Stuit<br />

US Bank<br />

Dave & Beth Van Portfliet<br />

Brian & Lori Vander Baan<br />

Wells Fargo<br />

Wells Fargo Advisors<br />

West Michigan Woman<br />

Zip Xpress, Inc.<br />

Couture for a Cure<br />

Amway<br />

Bengtson Center for Aesthetics &<br />

Plastic Surgery<br />

Franco & Alessandra Bianchi<br />

Chuck & Christine Boelkins<br />

Cheeky Strut<br />

Consumers Credit Union<br />

Mimi Cummings<br />

Cumulus<br />

CWD Real Estate Investment<br />

David & Carol Van Andel Family Foundation<br />

Deloitte<br />

Brian DeVries & Barbara Pugh<br />

Divani<br />

Eileen DeVries Family Foundation<br />

Eurest<br />

First National Bank<br />

Gallagher Insurance<br />

Jana Hall<br />

Kurt & Madelon Hassberger<br />

Paul & Sheryl Haverkate<br />

Dave & Donna Hockstra<br />

Bill & Starr Humphries<br />

Jandernoa Foundation<br />

Jeffery Roberts Design<br />

Dr. Peter & Veronica Jones<br />

Lake Michigan Credit Union<br />

McAlvey Merchant & Associates<br />

Deb Meijer<br />

Mercy Health<br />

Modern Day Collective<br />

Nothing Bundt Cakes<br />

Tom & Brenda Rinks<br />

Scott Group Studio<br />

The Steve & Amy Van Andel Foundation<br />

Todd Wenzel Automotive<br />

Townsquare Media<br />

Sharon Van Dellen<br />

Mike & Bonnie Walters<br />

West Michigan Woman<br />

Wheelhouse Kitchen & Cocktails<br />

Greg & Meg Willit<br />

Jim & Jane Zwiers<br />

<strong>Hope</strong> on the Hill<br />

Amway<br />

Amway Grand Plaza Hotel<br />

Anonymous<br />

Aon<br />

Aquinas College<br />

Autocam Medical<br />

Betz Industries<br />

BHS Insurance<br />

Dave & Jill Bielema<br />

Bluewater Technologies<br />

Chuck & Christine Boelkins<br />

BRAVO<br />

Buist Electric<br />

Butcher’s Union<br />

Jerry & Suzanne Callahan<br />

Cancer & Hematology Centers <strong>of</strong><br />

Western Michigan<br />

Cascade Rental<br />

Center for Physical Rehabilitation<br />

CityFlatsHotel<br />

Colliers International<br />

Crowe LLP<br />

Cumulus Media<br />

Tom & Tracy Curran<br />

Custer Inc.<br />

Davenport University<br />

David & Carol Van Andel Family Foundation<br />

Deloitte<br />

Divani<br />

Jeff & Mary Dixon<br />

Eenhoorn, LLC<br />

Ellis Parking Company<br />

Erhardt Construction<br />

Ferris C<strong>of</strong>fee & Nut Co.<br />

Fifth Third Bank<br />

Foremost Insurance Company<br />

Fred L. Hansen Corporation<br />

Gallagher Insurance<br />

Grand Valley State University<br />

Martin & Peggy Greydanus<br />

Kurt & Madelon Hassberger<br />

HealthBridge<br />

<strong>Hope</strong> College<br />

<strong>Hope</strong> Network<br />

Howard Miller<br />

Huizenga Group<br />

Ice Sculptures, LTD<br />

ICN Foundation<br />

iHeart Media<br />

Independent Bank<br />

Jandernoa Foundation<br />

Julie & Dan Horning Family FUN’d<br />

Craig & Debra Kinney<br />

Kitchen 67<br />

Al & Robin Koop<br />

Blake & Mary Krueger<br />

Lake Michigan Credit Union<br />

Ray & Jeannine Lanning<br />

Leo’s<br />

Lighthouse Group<br />

Gary & Vicky Ludema<br />

Macatawa Bank<br />

McAlvey Merchant & Associates<br />

Mercy Health<br />

Merrill Lynch — The Veldheer, Long,<br />

Mackay & Bernecker Group<br />

Metro Health<br />

22 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


Michelle Crumback Jewelry<br />

Michigan State University College <strong>of</strong><br />

Human Medicine<br />

MLive Media Group<br />

Modern Day Collective<br />

New Holland Brewing<br />

Norris Perne & French, LLP<br />

Nothing Bundt Cakes<br />

Orthopaedic Associates <strong>of</strong> Michigan<br />

Owens-Ames-Kimball Co.<br />

Peter C. & Emajean Cook Foundation<br />

Pioneer Construction<br />

Pitsch Company<br />

Plastic Surgery Associates<br />

Priority Health<br />

Quality Air Service, Inc.<br />

Rehmann<br />

Reserve Wine & Food<br />

Rockford Construction<br />

Eve Rogus & Paul Becker<br />

Rowerdink Inc.<br />

Tony & Dawn Semple<br />

Slows Bar BQ<br />

Spectrum Health<br />

Rob & Susan Stafford<br />

Steelcase<br />

Stephen Klotz Family Foundation<br />

Sweetie-licious Bakery<br />

Taconic Charitable Foundation<br />

Terra<br />

The Chop House<br />

The Meijer Foundation<br />

The Sharpe Collection<br />

The Steve & Amy Van Andel Foundation<br />

Thomas S. Fox Family<br />

Townsquare Media<br />

US Bank<br />

Mike & Michelle Van Dyke<br />

Van Eerden Food Service Company<br />

Warner Norcross + Judd LLP<br />

Wells Fargo<br />

West Michigan Woman<br />

Wheelhouse Kitchen & Cocktails<br />

Greg & Meg Willit<br />

Wolverine Worldwide<br />

Women’s Lifestyle<br />

Jim & Jane Zwiers<br />

A Conversation About Metabolism<br />

Hosted by Carol Van Andel<br />

Cornerstone University<br />

Gallagher Insurance<br />

Howard Miller<br />

iHeart Media<br />

Jana Hall<br />

Kent County Medical Society Alliance<br />

Leigh’s<br />

Townsquare Media<br />

West Michigan Woman<br />

Dr. Bart & Wendy Williams<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 23


PURPLE COMMUNITY<br />

STUDENTS HONE LEADERSHIP SKILLS AT VAI PURPLE<br />

COMMUNITY LUNCH & LEARN<br />

Katie Tietema first heard about the<br />

Van Andel Institute Purple Community<br />

Leadership Lunch & Learn when a<br />

representative from VAI reached out<br />

to St. Paul the Apostle School, where<br />

Tietema works.<br />

Tietema was immediately intrigued by the<br />

event, which brings together dozens <strong>of</strong><br />

students and educators to learn about the<br />

biomedical research and science education<br />

initiatives happening at VAI. Tietema helped<br />

assemble a group <strong>of</strong> 70 students and<br />

teachers to attend.<br />

“Every single student we brought knows<br />

someone in their family or has a close<br />

friend who has been impacted by one <strong>of</strong> the<br />

diseases being studied at VAI,” Tietema said.<br />

“It’s sad but true, and it makes the Institute’s<br />

mission very relevant to our students.”<br />

The October 2019 PC Lunch & Learn was<br />

the Institute’s fourth annual and the first<br />

to be open to all schools. Approximately<br />

180 students and educators attended, the<br />

largest group in the event’s history.<br />

Attendees were welcomed by WOOD-TV’s<br />

Maranda, who emceed the event. Groups<br />

were given tours <strong>of</strong> Van Andel Institute<br />

for Education’s lab nearby, where chief<br />

education <strong>of</strong>ficer Terra Tarango explained<br />

the Institute’s work and how her team<br />

creates classrooms where curiosity,<br />

creativity and critical thinking thrive.<br />

Students even participated in hands-on<br />

experiments.<br />

WEST MICHIGAN STUDENTS LUNCH & LEARN WITH PURPLE COMMUNITY<br />

Dr. Payton Stevens, a postdoctoral fellow<br />

in the lab <strong>of</strong> Dr. Bart Williams, hosted<br />

a discussion with attendees about the<br />

biomedical research being done at the<br />

Institute. Stevens shared with students how<br />

community support helps scientists at VAI<br />

pursue breakthroughs that may improve<br />

outcomes for patients with diseases like<br />

Parkinson’s and cancer.<br />

Tietema and her group were so impressed<br />

by the event that they decided to partner<br />

with Purple Community for St. Paul the<br />

Apostle’s annual Parish 5K & Festival<br />

fundraiser. Tietema said teachers at the<br />

school also plan to attend future Lunch &<br />

Learn events. This year will be the first time<br />

the Institute will host two Lunch & Learn<br />

events; one is in March and another in<br />

October.<br />

“Our students were so excited and asked so<br />

many great questions during the PC Lunch<br />

& Learn,” she said. “It was great to see how<br />

engaged and interested they were.”<br />

To learn more about Van Andel Institute Purple<br />

Community events, visit purplecommunity.org.<br />

24 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 25


PHILANTHROPY<br />

DR. JUAN OLIVAREZ, DONOR<br />

AND TRUSTEE, IS INSPIRED TO<br />

MAKE A DIFFERENCE<br />

Dr. Juan Olivarez discovered the value <strong>of</strong><br />

education early in life, and he has been<br />

helping others learn ever since.<br />

“I had a brother with Down syndrome,<br />

and when we were growing up, I was his<br />

protector and teacher,” Olivarez said. “I<br />

always loved being there for him and feeling<br />

like I was helping him learn something new.”<br />

medicine, research and education. This<br />

place is a miracle.”<br />

Olivarez and his son both fought battles<br />

against cancer, and this personal<br />

connection to the Institute’s research has<br />

given him a special perspective regarding<br />

the importance <strong>of</strong> science, awareness and<br />

discoveries that can impact human lives.<br />

A former teacher and clinical psychologist,<br />

an accomplished university administrator<br />

and a generous philanthropist, Olivarez has<br />

supported Van Andel Institute’s mission and<br />

education initiatives since 2008, both as a<br />

board member and a donor. While serving<br />

as president <strong>of</strong> Grand Rapids Community<br />

College, Olivarez met David and Carol<br />

Van Andel. He was inspired by their passion<br />

for biomedical research and science<br />

education and became interested in the<br />

Institute they helped found.<br />

“I knew Carol from working with her on<br />

philanthropic events, and when David asked<br />

me to join the Board <strong>of</strong> Trustees for<br />

Van Andel Institute for Education, I proudly<br />

and enthusiastically accepted,” he said. “I<br />

knew from the beginning that the Institute<br />

is a gem in our community and how very<br />

lucky we are to have it here.”<br />

Having lived in Grand Rapids for more than<br />

48 years, Olivarez is amazed by the impact<br />

VAI has had on the region and the city he<br />

and his wife, Mary, call home.<br />

“There is no doubt the establishment <strong>of</strong> the<br />

Institute in 1996 is a marker for a shift in<br />

the city’s skyline, as well as the education<br />

and research infrastructure <strong>of</strong> Grand<br />

Rapids,” Olivarez said. “It’s really hard to<br />

believe everything the Institute has done<br />

in such a short amount <strong>of</strong> time — what<br />

started as the Van Andel family’s dream is<br />

now a national and international hub for<br />

“It’s really hard to believe<br />

everything the Institute has<br />

done in such a short amount<br />

<strong>of</strong> time — what started as<br />

the Van Andel family’s<br />

dream is now a national<br />

and international hub for<br />

medicine, research and<br />

education. This place is a<br />

miracle.”<br />

— DR. JUAN OLIVAREZ<br />

“As a survivor and a person whose family<br />

has been affected by cancer, I am well<br />

aware that we need better treatments and<br />

cures. I also know that if we can continue<br />

to support research with discipline and<br />

tenacity, we will one day find them.”<br />

Join Dr. Olivarez and become a VAI donor<br />

today. Contact Brett Holleman at brett.<br />

holleman@vai.org to learn how you can<br />

support the Institute’s scientists in their<br />

fight against cancer, Parkinson’s and<br />

other diseases.<br />

DR. JUAN & MARY OLIVAREZ<br />

26 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 27


PHILANTHROPY<br />

HOW VAN ANDEL INSTITUTE PURPLE COMMUNITY<br />

HELPS MAKE FUNDRAISING EVENTS A HIT<br />

For 13 years, Pat Ringnalda has been<br />

hosting the Bee Brave 5K to raise money<br />

for breast cancer research. Organizing<br />

the event is a heavy lift, but for the last<br />

three years, that work has been made<br />

easier with help from Van Andel Institute<br />

Purple Community.<br />

Bee Brave, which celebrated its 12th run<br />

in 2019, began partnering with Purple<br />

Community after Ringnalda attended a golf<br />

outing to benefit VAI’s scientific research.<br />

Ringnalda was impressed by the support<br />

Purple Community gives its community<br />

and corporate partners to carry out<br />

such events. The more she learned, the<br />

more she realized the Bee Brave 5K would<br />

benefit greatly from partnering with Purple<br />

Community.<br />

“I have <strong>of</strong>ten said, if God gives you the<br />

nerve to ask people for money to support<br />

great causes, do it!” Ringnalda said. “You<br />

start with the best institutions like VAI,<br />

because they will give you the tools and<br />

support you need to be successful in your<br />

efforts.”<br />

The Bee Brave 5K is one <strong>of</strong> dozens <strong>of</strong><br />

community events hosted each year to<br />

benefit scientific research and education<br />

programs at the Institute. Many people who<br />

organize these events begin by wanting to<br />

donate to a good cause, but are unsure<br />

how to get started.<br />

Purple Community makes it easy using an<br />

online application that outlines each event’s<br />

needs such as expected event location, size<br />

and fundraising goal. Once the application<br />

is received, it’s reviewed to determine how<br />

Purple Community can best support the<br />

event. Examples include setting up online<br />

fundraising portals, designing event fliers<br />

and more.<br />

“Community events are an essential part <strong>of</strong><br />

supporting the important work happening<br />

at VAI,” said Purple Community volunteer<br />

coordinator McKenzie Hollern. “We want<br />

our organizers to know how much we<br />

appreciate their efforts by <strong>of</strong>fering our full<br />

support and resources to make their events<br />

a success.”<br />

To learn more, visit purplecommunity.org.<br />

PAT RINGNALDA (RIGHT)<br />

28 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


KAY KOO HONORS FAMILY LEGACY OF GIVING<br />

When Kay Koo and her husband,<br />

Dr. Han-Mo Koo, arrived in Grand<br />

Rapids from Maryland in 1999, the<br />

city’s downtown was a sparse collection<br />

<strong>of</strong> shuttered businesses, fast food<br />

restaurants and a few beautiful, old<br />

churches. There was not, however, a<br />

research institute back then. Dr. Koo was<br />

one <strong>of</strong> the first scientists asked by Dr.<br />

George Vande Woude, a cancer research<br />

pioneer and Van Andel Institute’s first<br />

director <strong>of</strong> research, to help build<br />

Van Andel Institute from the ground up.<br />

“I feel a connection with what my husband<br />

started 20 years ago,” Koo said. “The<br />

Institute has my heart, and I hope we<br />

continue to grow and come up with new<br />

therapies for diseases that affect the lives<br />

<strong>of</strong> our loved ones. I really think my husband<br />

would be proud <strong>of</strong> what the Institute has<br />

become.”<br />

“We came here because we respected the<br />

work <strong>of</strong> Dr. Vande Woude, and even though<br />

there was not a lot going on in Grand<br />

Rapids at the time, we knew it would be<br />

exciting to be part <strong>of</strong> something new that<br />

didn’t exist yet,” Koo said.<br />

Dr. Koo served as head <strong>of</strong> the Institute’s<br />

Laboratory <strong>of</strong> Cancer Pharmacogenetics<br />

until he lost a six-month battle with<br />

cancer in 2004. His work focused on the<br />

identification <strong>of</strong> genetic targets for anticancer<br />

drug development for melanoma<br />

and pancreatic cancer. He was also<br />

an active contributor to the Institute’s<br />

Employee Impact Campaign that supported<br />

his fellow scientists. After his passing, Koo<br />

began working at the Institute as Dr. Vande<br />

Woude’s administrative assistant. Like<br />

her husband, Koo continued their family’s<br />

legacy <strong>of</strong> generosity as an employee donor.<br />

“I come from a family <strong>of</strong> giving. I grew up as<br />

the daughter <strong>of</strong> a pastor in a family where<br />

giving <strong>of</strong> yourself was just so natural,” Koo<br />

said. “I give to honor my husband’s memory<br />

and to support the people who helped me<br />

when he was so sick.”<br />

Koo recently surpassed her 15th year as<br />

a VAI employee, and after a decade and a<br />

half <strong>of</strong> service to the mission, the Institute<br />

is more than a place to work — it’s a family.<br />

KAY KOO<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 29


PHILANTHROPY<br />

MEMORIALS<br />

We appreciate your trust in us to fight disease in memory or in honor <strong>of</strong><br />

your family and friend s — with hope for a healthier tomorrow. To make a<br />

gift in memory or honor <strong>of</strong> a loved one, please call 616.234.5552.<br />

Alison “Awesome Ali”<br />

Aardema<br />

Steven & Julie Aardema<br />

Shirley Alt<strong>of</strong>t<br />

James & Frieda Jaynes<br />

Lorrie Jaynes<br />

Dominic “Nick” Amante<br />

Gerald & Mary McDermott<br />

Robert Anderson<br />

David & Lynne Robinson<br />

Jean Atkinson<br />

David & Patti Atkinson<br />

David Barney<br />

Bruce & Carolyn Tuttleman<br />

Keith Bassett<br />

Jean Bassett<br />

Jeanne Bergsma<br />

Jean Swaney<br />

James Breay<br />

David Solis<br />

Chester Bush<br />

David & Carol Van Andel<br />

Family Foundation<br />

Robert Bylenga<br />

William & Jackie Bylenga<br />

Peter Bylsma<br />

Carol Bylsma<br />

Frank Campbell<br />

Paul & Lynn Getzin<br />

Robert Campbell<br />

Jean Swaney<br />

David Christie<br />

Roxanne Anderson<br />

Elizabeth Cobb<br />

Jean Swaney<br />

Patti Ditmar<br />

Florence Barrett<br />

Jack & Rhonda Barrett<br />

Rod & Kerri Brandsen<br />

Joseph & Suzanne Dahms<br />

Lois Dickinson<br />

Ryne & Julie Dickinson<br />

Jan Hall<br />

Stephen Heneveld<br />

Steve & Linda Kammeraad<br />

Joel & Karlene Krause<br />

Maureen Dobson<br />

Lake Michigan Dental<br />

Peerless Steel<br />

John & Lisa Wilson<br />

Kathleen Drennan<br />

Brock & Katie Plumb<br />

Robert DuHadway<br />

Richard & Terri MacKeigan<br />

Bill & Linda Peterson<br />

Terry & Laura Reese<br />

John & Judith Wavro<br />

David & Deborah Wurfel<br />

Mary Kate (Katie) Dutcher<br />

Daniel & Mona Morgan<br />

Sam Smits & Edith<br />

Wehrly-Smits<br />

Katherine Williams<br />

Melissa Eden<br />

Keith & Carolyn Murphy<br />

Charles Emmerich<br />

Charles & Nancy Emmerich<br />

Douglas & Nancy Knobloch<br />

Todd & Cynthia Ross<br />

Patrick & Sue Van Duinen<br />

Francine Erb<br />

Wally & Nina Gorak<br />

Bernard Forystek<br />

James & Kimberle Johnson<br />

Fredrick Gleason<br />

David Bevins<br />

Timothy Haak<br />

Mary Haak<br />

Gisela Kah<br />

JoAnn Crary<br />

Dixie Anderson<br />

David & Carol Van Andel<br />

Family Foundation<br />

The Dick & Betsy DeVos<br />

Family Foundation<br />

Fifth Third Bank<br />

Dan & Lou Ann Gaydou<br />

Gerald R. Ford International<br />

Airport<br />

Greg Northrup & Birgit Klohs<br />

Horst & Margot Lach<br />

Michigan State University<br />

College <strong>of</strong> Human Medicine<br />

Jon Nunn<br />

The Right Place, Inc.<br />

Ulrich & Martina Schlagwein<br />

Doug Small<br />

Robert Spohr<br />

Jim Teets<br />

Terryberry Company LLC<br />

Mark Kastner<br />

Brenda Kastner<br />

Nathanael Kastner<br />

Frank Krhovsky<br />

James & Florence Bouwman<br />

Renee Kuipers<br />

Gordon & Mary Buitendorp<br />

Sue Chavron<br />

Frank & Kerrie Doezema<br />

Bruce & Esther Drukker<br />

Carl & Sandy Gronsman<br />

Lake Michigan Dental<br />

Evan & Lois Reinders<br />

Sanford Leestma<br />

David & Linda Male<br />

Irma Leonard<br />

Joseph & Margaret Biersack<br />

Victor Leslie<br />

Jean Swaney<br />

Michelle Lunn<br />

Michelle Lunn <strong>Hope</strong><br />

Foundation<br />

Jane McConnell<br />

Memorial Alternatives<br />

Philip McCorkle<br />

David & Carol Van Andel<br />

Family Foundation<br />

John Moliassa<br />

Matt & Robin Dhaseleer<br />

John & Ann Moliassa<br />

Charlotte Mulder<br />

Roger & Beverly Mulder<br />

Bruce O’Connor<br />

Wally & Nina Gorak<br />

Thomas Peterson<br />

Anonymous<br />

Michael & Barbara Corey<br />

Jody Davis<br />

Stephen & Lynne Kindy<br />

Erik & Sally Klimek<br />

Debra Landers<br />

Jan London<br />

Eric & Ruth McClure<br />

Michelle Oole<br />

Mark & Jill Smith<br />

Denise Picardat<br />

Brian & Denise Picardat<br />

James Ponitz<br />

Kathleen Ponitz<br />

Jean Prose<br />

Wally & Nina Gorak<br />

Richard Pullen<br />

Ruth Kemp<br />

Neda Raterink<br />

Gary & Neda Raterink<br />

Rose Ray<br />

Eugene & Barbara Gutting<br />

David L. Rossi<br />

Anne Rossi<br />

John & Lucille Ryan<br />

Donald & Patricia Patterson<br />

Amy Schneider<br />

JoEllen Schneider<br />

Rajindeer Singh<br />

Puneet Chowdhary<br />

Cynthia Smith<br />

Christa Cook<br />

Daniel & Evelyn Preston<br />

Larry & Barbara Smith<br />

Doug & Maryln Walton<br />

Keith Smith<br />

Carol Smith<br />

Ben Snoeyink<br />

Baker Perkins, Inc.<br />

Dale & Phyllis de Longpre<br />

Allen & Vivian DeJonge<br />

Gary & Terri Dewey<br />

Mark & Donna Dezwarte<br />

Frank & Kerrie Doezema<br />

Timothy & Kristin Gabrielse<br />

Carl & Sandy Gronsman<br />

Curtis & Kristine Hancock<br />

Laura Palsrok<br />

Jay & Beverly Pruim<br />

Burton & Phyllis Rozema<br />

The Rozema Family Fund<br />

Marianne Stehouwer<br />

Robert & Marjorie Stuit<br />

Eric & Pat Symanski<br />

Dean & Carol Vanbruggen<br />

Charlotte Stein<br />

Keith & Theresa Kiel<br />

Susan Suwyn<br />

Scott Cavanaugh<br />

Ronald Swiderek<br />

Ronald & Alice Swiderek<br />

Daniel Terwee<br />

Brian & Dianne Boelens<br />

Fred & Doris Mowery<br />

Lewis & Nancy Travis<br />

Donald Van Artsen<br />

Timothy & Terri Blanch<br />

Sydney Edlund<br />

Jon & Mary Forslund<br />

William & Marilyn Lundquist<br />

30 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE


TRIBUTES<br />

(Donald Van Artsen cont.)<br />

Dick & Connie Murley<br />

James & Lois VanVeghel<br />

Gordon Van Harn<br />

Roger & Susan Bratt<br />

Dale Vanderstelt<br />

Dale & Pamela Vanderstelt<br />

Timothy S. Vanderveen<br />

Ted & Joan Vanderveen<br />

Barbara VanHeulen<br />

Dave & Sally Baker<br />

Shirley Baumgardner<br />

Raymond & Priscilla Becker<br />

Mark & Marcia Borton<br />

Jack & Donna Boukma<br />

Carol Brooks<br />

Gracespring Bible Church<br />

Scott & Peggy Powlus<br />

Karl & Linda Prescher<br />

Susan Reinoehl<br />

Richard & Lori Teft<br />

Frank Vereecken<br />

David & Judy Aniszko<br />

Maribeth Constantine<br />

Frank & Jennifer Edwards<br />

James & Frances Norton<br />

Sally Norton<br />

Arthur & Karen Olson<br />

Sharon Wieland<br />

Albert Walcher<br />

Raymond & Gretchen Meyer<br />

Claudia Azkoul Walters<br />

James & Joy DeBoer<br />

Jennifer Webb<br />

David & Sallie Brinks<br />

Eric Westra<br />

Dianna DeVries<br />

Jack & Sandra Dik<br />

Thomas & Mary Beth Henry<br />

Ben & Robin Ipema<br />

Thomas & Donna Webb<br />

Randy Winchester<br />

Chuck & Lois Winchester<br />

Jerry Wright<br />

John & Andrea Cain<br />

Fishbeck, Thompson, Carr<br />

& Huber, Inc.<br />

Thomas & Julie Wright<br />

Jacob Zagaroli<br />

George & Linda Sharpe<br />

Gabe Amodeo<br />

Catherine Amodeo<br />

Richard Lutz<br />

Margaret Fondren<br />

David & Carol Van Andel<br />

Scott & Maggie Lancaster<br />

Richard & Terri MacKeigan<br />

Evan Beukema<br />

Emma Beukema<br />

Scott Bravata<br />

Universal Forest Products<br />

Inc.<br />

Steven Kruith<strong>of</strong>f<br />

Edward & Karen Bezilla<br />

Victoria Ludema<br />

Crowe LLP<br />

Thomas Newh<strong>of</strong><br />

James & Pamela Hegarty<br />

Ken & Jill Peirce<br />

Christopher & Renee Peirce<br />

George Sharpe<br />

Thomas & Jeannine Rizzo<br />

Greg & Meg Willit<br />

Duke Suwyn<br />

Kimberly Van Stee<br />

Alvin & Joyce Docter<br />

James Veldheer<br />

Greg & Karin McAleenan<br />

These lists represent gifts made between July 1, 2019, and December 31, 2019. The accuracy <strong>of</strong><br />

these lists is very important to us. Please contact 616.234.5552 if an error has been made.<br />

Honoring loved ones with a memorial gift to VAI<br />

Our mother, Gisela Kah, was a vibrant, vital woman who passed away this<br />

summer after a decade-long struggle with dementia. We chose to honor<br />

her by creating a memorial fund at Van Andel Institute. These tributes<br />

fund the important research at VAI in a deeply personal, meaningful<br />

way. We take comfort knowing that a gift in our mother’s name moves<br />

scientists and society ever closer to finding the next breakthroughs in<br />

treating the diseases that take our loved ones too soon.<br />

— Birgit Klohs<br />

— Greg Northrup<br />

— Astrid Müller<br />

— Julia Müller<br />

VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 31

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