2020 Spring/Summer Highlights of Hope
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HIGHLIGHTS OF HOPE | SPRING/SUMMER ’20 ISSUE<br />
2 10 Research Trends 4 MSA Clinical Trial 6 Tackling a Rare Disease 8–9 VAI Employee Spotlights 10–11 Graduate School Spotlights<br />
12 San Juan Diego Academy Pilots Blue Apple 13 VAI <strong>Summer</strong> Camps 14 Events 22 Event Sponsors 24 PC Lunch & Learn<br />
26 Donor Spotlight: Dr. Juan Olivarez 28 Fundraising with VAI 29 Employee Donor Spotlight: Kay Koo 30 Memorials & Tributes
RESEARCH<br />
10 RESEARCH TRENDS WE’RE EXCITED TO<br />
WATCH IN THE NEXT DECADE<br />
With a new decade comes a new world <strong>of</strong> possibility, and<br />
innovation waiting to be unleashed in labs at Van Andel<br />
Institute and across the globe. As we take our first steps into the<br />
<strong>2020</strong>s, here are 10 promising research trends to keep an eye on<br />
now and in the coming years.<br />
Our understanding <strong>of</strong> Parkinson’s disease will continue to<br />
evolve, spurring new research and breakthroughs<br />
Parkinson’s disease has long been considered a movement-related<br />
disorder that originates in the brain. Recent research, however,<br />
suggests that Parkinson’s disease might represent a group <strong>of</strong><br />
closely related disorders. While they share key clinical features,<br />
they may have roots in different anatomical locations, such as the<br />
gut and nose. Even if the anatomical starting points differ, there is<br />
evidence that cell metabolism, inflammation and poor handling <strong>of</strong><br />
certain proteins are common features. In the coming years, these<br />
insights could lead to the development <strong>of</strong> new therapies to slow or<br />
stop its progression.<br />
Breakthroughs in common diseases like Parkinson’s, dementia<br />
with Lewy bodies and Alzheimer’s might help us better<br />
understand rare disorders<br />
It’s become increasingly clear that an improved understanding <strong>of</strong><br />
one disease may provide new insights into another. For rare and<br />
understudied diseases like multiple system atrophy, this provides<br />
a particularly important opportunity to gain the insight required to<br />
develop new diagnostics and treatments.<br />
Inflammation will increasingly be linked to disease — and give<br />
rise to new treatments<br />
Inflammation is a normal part <strong>of</strong> the immune system, responsible<br />
for marshalling resources to the site <strong>of</strong> a wound, infection or<br />
disease (like cancer) to help the body fight back. When inflammation<br />
remains longer than needed, it can cause or contribute to a host <strong>of</strong><br />
health problems. Researchers are hard at work sorting out exactly<br />
how and why this happens, which could be the findings that serve<br />
as the foundation for new therapies for cancer, neurodegenerative<br />
diseases, depression and many others.<br />
Understanding how the body processes, uses and stores<br />
energy will be critically important<br />
Metabolism powers every aspect <strong>of</strong> the human body, from<br />
keeping the immune system running to ensuring our hearts have<br />
enough energy to beat. We’ve known for some time that metabolic<br />
dysfunction plays a central role in diseases like diabetes and even<br />
in cancer, thanks to malignant cells’ voracious appetites for energy.<br />
But new breakthroughs also have linked issues with metabolism<br />
to neurodegenerative diseases like Parkinson’s and Alzheimer’s,<br />
among others. As we better understand our bodies’ incredibly<br />
complex web <strong>of</strong> metabolic processes, it’s likely that we will continue<br />
to find metabolism at the center <strong>of</strong> many disorders — and many<br />
future treatments.<br />
Cancer treatment will harness combinations <strong>of</strong> medications<br />
designed to give cancer a one-two punch<br />
We now know that cancer comprises more than 100 different<br />
diseases, each with its own litany <strong>of</strong> subtypes (for example, breast<br />
cancers can be defined based on the presence or absence <strong>of</strong><br />
certain molecular receptors). This expansive diversity means that<br />
there is likely no silver bullet cure. Instead, we can expect to see<br />
more combination therapies that utilize multiple medications<br />
whose effects complement or enhance each other’s ability to fight<br />
cancers. A prime example is pairing an immunotherapy drug,<br />
which bolsters the body’s natural defenses against cancer, with<br />
an epigenetic drug that makes cancer cells more recognizable,<br />
more susceptible to immune attack, and is thought to reinvigorate<br />
exhausted immune cells and get them back in the fight.<br />
We will better understand how the health and diet <strong>of</strong> one<br />
generation can affect the next<br />
Can a parent’s diet, experiences and lifestyle impact their children?<br />
Or subsequent generations? Mounting evidence suggests that<br />
nutrition does indeed have a ripple effect across generations, even<br />
altering individuals’ predisposition to disease. Efforts are underway<br />
to better understand how nutrition and other environmental<br />
factors reprogram the genome and epigenome, and how this<br />
information traverses generations. The goal: developing ways<br />
to prevent and treat diseases including diabetes, cancer, and<br />
Parkinson’s, and to protect our children from the unwanted<br />
consequences <strong>of</strong> our own lifestyles.<br />
We will see the translation <strong>of</strong> structural findings into<br />
actionable therapies<br />
Structural biology seeks to determine the shape and architecture<br />
<strong>of</strong> life’s smallest building blocks, such as proteins. These efforts<br />
are vitally important, helping us understand in intricate chemical<br />
detail how the body works and laying the earliest foundations for<br />
new medications. In the past five years, there has been a boom<br />
in structural research, based on technological advances in cryoelectron<br />
microscopy (cryo-EM), a technique that helps scientists<br />
view molecules down to the atomic level. In the next decade, we will<br />
continue to build on these foundational discoveries, which could<br />
give rise to new treatments.<br />
2 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
We’ll learn more about microenvironments and microbiomes<br />
and their role in cancer and other diseases<br />
In many ways, the future will be “micro.” Our technology is<br />
miniaturizing; we are able to study the tiniest components <strong>of</strong><br />
life in ways never before possible and scientists are increasingly<br />
understanding the importance and diversity <strong>of</strong> microenvironments,<br />
the mini ecosystems that exist throughout the body. In cancer, the<br />
microenvironment is the area immediately surrounding a tumor,<br />
which can comprise blood vessels, immune cells and structural<br />
cells, among others. These areas <strong>of</strong>fer windows into how specific<br />
cancers grow and proliferate, and may even <strong>of</strong>fer new solutions<br />
for stopping them. We’re also learning more about the role <strong>of</strong><br />
microbiomes, the host <strong>of</strong> microscopic organisms such as bacteria<br />
that inhabit specific areas <strong>of</strong> the body like the gut. For example,<br />
researchers who are sleuthing out the links between the gut and<br />
Parkinson’s disease are taking a look at the gut microbiome as a<br />
possible factor in disease onset.<br />
Technology will spur even more innovation<br />
Editing genes using CRISPR. Determining molecular structures<br />
with high-powered cryo-EM. Decoding the genome through nextgeneration<br />
sequencing. The advent <strong>of</strong> these powerful technological<br />
tools, paired with increasingly robust computational capabilities,<br />
have revolutionized how we study health and disease, and already<br />
have contributed to critical biomedical breakthroughs. With<br />
technology continually advancing, we can only expect the innovation<br />
to continue in years to come.<br />
Big Data will continue to yield new insights<br />
Big Data refers to the massive amounts <strong>of</strong> information generated<br />
by certain types <strong>of</strong> research, such as genomics. With technology<br />
improving every day, the amount <strong>of</strong> data being churned out will only<br />
continue to balloon, presenting opportunities and challenges to<br />
scientists working to get to the root <strong>of</strong> disease. By closely analyzing<br />
large datasets (a monumental task itself), scientists can look for<br />
patterns linked to disease. A prime example is The Cancer Genome<br />
Atlas, a National Institutes <strong>of</strong> Health-led effort that molecularly<br />
mapped 33 different types <strong>of</strong> cancer. These highly detailed and vast<br />
datasets helped identify important variations in cancer types and<br />
subtypes that may form the foundation <strong>of</strong> new targeted therapies.<br />
To read more about Van Andel Institute’s research in these areas, visit<br />
vai.org/10-trends-<strong>2020</strong>s.<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 3
RESEARCH<br />
CAN A DIABETES DRUG SLOW OR STOP A<br />
DEVASTATING NEURODEGENERATIVE DISEASE?<br />
A NEW CLINICAL TRIAL GIVES HOPE TO PEOPLE WITH MULTIPLE SYSTEM ATROPHY<br />
Philip Fortier is on a mission: to find a cure for multiple system<br />
atrophy, a devastating neurodegenerative disease that lacks<br />
an effective way to halt progression.<br />
For him, it’s deeply personal. His brother, Joe, battled MSA for three<br />
years before passing away in 2013. Now, the organization the<br />
Fortier family founded — Defeat MSA Alliance — has teamed up<br />
with Van Andel Institute and others to support a groundbreaking<br />
clinical trial to see if a common diabetes drug called exenatide may<br />
also impede MSA’s rapid course.<br />
“There are a great many people around the world suffering from<br />
MSA and there are no drugs known to slow it down,” Fortier said.<br />
“Anything we can do to help research — to find a drug that can be<br />
repurposed to help people — is something we should and must<br />
do.”<br />
A tough foe<br />
MSA is a quick and cruel disease. Over the course <strong>of</strong> five to<br />
10 years, it ravages the body, shutting down the vital systems<br />
necessary to keep a person healthy and functioning like the ability<br />
to move, to regulate heart rate and to digest food. Between 15,000<br />
and 50,000 people in the U.S. have MSA. The exact number is<br />
tough to pin down because MSA is notoriously difficult to diagnose,<br />
particularly in its early stages when it <strong>of</strong>ten is mistaken for<br />
Parkinson’s disease.<br />
In fact, like Parkinson’s, many scientists also believe MSA is linked to<br />
a buildup <strong>of</strong> abnormal proteins called alpha-synuclein, which clog<br />
critical cells and cause them to die. In MSA, these cells are the glia,<br />
which support and protect the brain’s nerve cells.<br />
“We now know that MSA, Parkinson’s and another related disorder,<br />
Lewy body dementia, are all linked by alpha-synuclein,” Fortier<br />
said. “That has given us new hope that, with more research, we can<br />
possibly find something that gives people with MSA more years<br />
with fewer symptoms.”<br />
New hope<br />
The pilot trial is helmed by Pr<strong>of</strong>. Thomas Foltynie in collaboration<br />
with colleagues at University College London Queen Square<br />
Institute <strong>of</strong> Neurology and the UCLH National Hospital for<br />
Neurology and Neurosurgery in London. Two previous small<br />
clinical trials by Foltynie’s group have shown that exenatide is<br />
well-tolerated in patients and may slow Parkinson’s progression.<br />
Additionally, lab data in models <strong>of</strong> MSA and post-mortem data from<br />
the brains <strong>of</strong> people who had MSA indicate that exenatide may<br />
have positive effects.<br />
“There are a great many people around the<br />
world suffering from MSA and there are no<br />
drugs known to slow it down. Anything we<br />
can do to help research — to find a drug<br />
that can be repurposed to help people — is<br />
something we should and must do.”<br />
— PHILIP FORTIER<br />
The approach — repurposing a medication developed for one<br />
disease to treat another — is an innovative way to maximize<br />
scarce resources and shave <strong>of</strong>f precious time in the search for<br />
new treatments, said Dr. Patrik Brundin, director <strong>of</strong> VAI’s Center for<br />
Neurodegenerative Science and a Parkinson’s expert. Brundin’s lab<br />
also studies the origins <strong>of</strong> MSA and is investigating potential new<br />
therapies, such as another drug developed to treat diabetes as a<br />
possible treatment for Parkinson’s and MSA.<br />
“Although they look different on the surface, many diseases are<br />
linked to similar biological pathways. That’s why a diabetes drug has<br />
potential to treat neurological disorders like MSA and Parkinson’s,”<br />
Brundin said. “Repurposing is another tool for us to work quickly<br />
toward life-changing breakthroughs.”<br />
Fortier sees the trial as a bold new step forward in MSA research,<br />
bolstered by a collaborative group <strong>of</strong> organizations that have united<br />
to take on a particularly challenging adversary.<br />
4 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAI CHIEF DEVELOPMENT OFFICER BRETT HOLLEMAN, PHILIP FORTIER,<br />
DR. PATRIK BRUNDIN & VAI POSTDOCTORAL FELLOW DR. WOUTER PEELAERTS<br />
“If we are going to be successful, we need more research and<br />
we need to bring together people from across the scientific<br />
community,” Fortier said. “It’s a calling — to love and care for one<br />
another and do our best to help people with MSA.”<br />
The study is funded by the John Black Charitable Foundation in the<br />
U.K. and Van Andel Institute and the Defeat MSA Alliance in the U.S. The<br />
study is supported by the MSA Trust (U.K.).<br />
ABOUT MULTIPLE SYSTEM ATROPHY<br />
• Between 15,000 and 50,000 people in the<br />
U.S. have MSA<br />
• Symptoms most frequently appear after age 50<br />
• Early symptoms are frequently difficult to distinguish<br />
from Parkinson’s disease and include tremor, rigidity,<br />
slowed movement and impaired speech<br />
• Like Parkinson’s, MSA is considered to be a<br />
“synucleinopathy,” a disease marked by buildup<br />
<strong>of</strong> the protein alpha-synuclein.<br />
Source: National Institute <strong>of</strong> Neurological<br />
Disorders and Stroke<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 5
RESEARCH<br />
HOW BIG DATA AND COLLABORATION IS<br />
REDEFINING A RARE FORM OF DEMENTIA<br />
Van Andel Institute’s Dr. Rita Guerreiro and Dr. José Brás<br />
have teamed up with more than 100 other scientists from<br />
around the world to take on frontotemporal dementia, a<br />
rare disease that currently has no cure and no treatment<br />
that slows progression.<br />
In late 2019, the group led by Dr. Jonathan Rohrer at University<br />
College London published a wide-ranging study in The Lancet<br />
Neurology that provides new insight into FTD that could one<br />
day shape future treatments. Here’s a quick primer on FTD and<br />
breakdown <strong>of</strong> their findings.<br />
Frontotemporal dementia is rare and tough to define — and<br />
that makes it hard to study<br />
For more than a century, the exact name and definition <strong>of</strong><br />
frontotemporal dementia has been in flux. It is best described as<br />
a syndrome — a set <strong>of</strong> symptoms that <strong>of</strong>ten occur together. While<br />
the exact parameters <strong>of</strong> what constitutes FTD will likely evolve as<br />
we learn more, typical features <strong>of</strong> the disease include progressive<br />
shrinking <strong>of</strong> the frontal and anterior temporal lobes <strong>of</strong> the brain;<br />
that is, the brain’s front and bottom regions.<br />
Other FTD symptoms fall into two categories:<br />
• Behavioral changes, such as impulsive or listless behavior,<br />
inappropriate social behaviors, repetitive or compulsive<br />
behaviors, and agitation.<br />
• Difficulties with language, such as problems comprehending<br />
speech or with speaking. Often, these symptoms occur<br />
alongside behavioral symptoms.<br />
About one-third <strong>of</strong> FTD cases are genetic, meaning the disease can<br />
be directly linked to changes, or mutations, in specific genes.<br />
When it comes to rare diseases, collaboration is critical<br />
Rare diseases like FTD can be tough to study due in large part to<br />
their nature. There <strong>of</strong>ten simply aren’t enough cases from which to<br />
gather sufficient data. Moreover, while FTD is a rare disease, FTD<br />
caused by DNA mutations is even rarer.<br />
To establish what is typical for each mutation or for each gene,<br />
scientists must have enough cases with the same mutation or<br />
mutations in the same gene. This is only achievable by leveraging<br />
the collective power <strong>of</strong> research centers around the world. Each<br />
<strong>of</strong> these centers may only have a handful <strong>of</strong> cases but, when<br />
analyzed all together, scientists can start seeing patterns that<br />
would have been impossible to identify in the individual cohorts<br />
from each center.<br />
In this study, the team was able to compare data from 3,403<br />
individuals representing 1,492 families — far more than would be<br />
accessible at any one center. The result is a powerful overview <strong>of</strong><br />
genetic mutations that contribute to age <strong>of</strong> symptom onset, age <strong>of</strong><br />
death and length <strong>of</strong> disease in people with FTD.<br />
The findings lay an important foundation for future research<br />
and future treatment<br />
The study focused on the three genes most frequently mutated in<br />
FTD: MAPT, GRN and C9orf72. Here are a few examples from their<br />
findings:<br />
• GRN mutations were more likely to affect women than men.<br />
• People with MAPT mutations tended to be younger at symptom<br />
onset and at death.<br />
• People with C9orf72 mutations had the shortest disease<br />
duration, on average.<br />
Rare diseases like FTD can be<br />
tough to study due in large part<br />
to their nature. There <strong>of</strong>ten<br />
simply aren’t enough cases<br />
from which to gather sufficient<br />
data. Moreover, while FTD is a<br />
rare disease, FTD caused by DNA<br />
mutations is even rarer.<br />
Overall, the team was able to better characterize what is typical for<br />
rare mutations. This information is particularly important for people<br />
and families living with these mutations, for clinicians managing FTD<br />
and for drug developers assessing progression <strong>of</strong> disease in clinical<br />
trials.<br />
Additionally, a large-scale, Big Data study such as this allows<br />
scientists to better define disease subtypes by country and,<br />
ultimately, can move the field one step closer to precision medicine.<br />
6 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
DR. JOSÉ BRÁS & DR. RITA GUERREIRO<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 7
RESEARCH<br />
DAN ROGERS — NEW THERAPIES, ONE TRIAL AT A TIME<br />
All new therapies for diseases like cancer and Parkinson’s<br />
began in a lab — the culmination <strong>of</strong> years <strong>of</strong> research,<br />
scientific testing and rigorous clinical trials.<br />
These trials, which evaluate the safety and effectiveness <strong>of</strong> potential<br />
new treatments in real people, are the conduit that translate<br />
discoveries from the lab to a point where they can benefit patients.<br />
For more than five years, Dan Rogers, clinical research manager<br />
at Van Andel Institute, has helped organize and manage the<br />
Van Andel Institute–Stand Up To Cancer Epigenetics Dream<br />
Team, a collaborative effort that brings together leading scientists,<br />
physicians, philanthropic organizations and companies to improve<br />
the standard <strong>of</strong> cancer care. Along with a small but incredibly<br />
talented team <strong>of</strong> experts, Rogers helps the team to propel the<br />
discoveries made in labs into clinical testing — a critical step to<br />
getting new therapies to the patients who need them most.<br />
“When you hear David Van Andel, VAI’s<br />
chairman and CEO, say there are patients<br />
out there right now who are counting on<br />
us to come up with better treatments and<br />
diagnostics, it resonates with me the<br />
urgency <strong>of</strong> our mission.”<br />
— DAN ROGERS<br />
“My dad passed away from cancer in 2016 and was fortunate to<br />
live a long and quality life — even after diagnosis,” Rogers said. “I<br />
<strong>of</strong>ten think about how the work I am involved in now in advancing<br />
better treatment options for cancer patients have and will have an<br />
impact on people like my dad — extending their lives and giving<br />
them more time with their loved ones. When you hear David<br />
Van Andel, VAI’s chairman and CEO, say there are patients out<br />
there right now who are counting on us to come up with better<br />
treatments and diagnostics, it resonates with me the urgency <strong>of</strong><br />
our mission.”<br />
Rogers grew up in a family surrounded by medicine, science and<br />
the concept <strong>of</strong> service. His father worked for many years as an<br />
emergency room physician, which gave Rogers an early insight into<br />
the world <strong>of</strong> patient care.<br />
“As any typical young person, I resisted working in the family<br />
business — medicine — for quite a while. But, after working as an<br />
emergency room tech as a summer job in college, I developed an<br />
understanding <strong>of</strong> the importance <strong>of</strong> helping those in need and<br />
DAN ROGERS<br />
I was hooked,” Rogers said. “Now, I have this great opportunity<br />
to work for an Institute that can benefit human health, and as a<br />
member <strong>of</strong> the team I can play a role in clinical trials that bring<br />
new therapies to patients across the U.S. and the world. And<br />
knowing that is really gratifying and humbling.”<br />
8 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
BRYN EAGLESON — ONE OF THE<br />
INSTITUTE’S ORIGINAL RECRUITS<br />
When Van Andel Institute’s founding<br />
director <strong>of</strong> research, Dr. George<br />
Vande Woude, started the Institute’s<br />
research program in 1999, he recruited<br />
bright, young scientists and experts<br />
to help him build something truly<br />
unique. One <strong>of</strong> those recruits was Bryn<br />
Eagleson. A director in the Institute’s Core<br />
Technologies and Services, her work directly<br />
supports scientists as they uncover new<br />
diagnostics and treatments for cancer,<br />
neurodegenerative disorders and many<br />
other diseases.<br />
Motivated by the Institute’s mission to<br />
benefit human health for current and<br />
future generations, and its collaborative,<br />
innovative work environment, Eagleson has<br />
made VAI her pr<strong>of</strong>essional home for more<br />
than 20 years. After two decades <strong>of</strong> hard<br />
work, she now understands the role her<br />
work has played in helping shape VAI into<br />
a global epicenter for biomedical research<br />
and education. With no plans to slow down,<br />
Eagleson looks forward to serving the<br />
Institute’s mission until she retires.<br />
“My hope is that all <strong>of</strong> this cutting-edge<br />
research can soon become translated into<br />
new ways to help people in the clinic, and<br />
that our work can have a lasting benefit to<br />
human health,” she said. “It’s been amazing<br />
to build something from the beginning and<br />
to know my work has contributed to this<br />
incredible research. It is truly something I<br />
am so proud to be a part <strong>of</strong>.”<br />
BRYN EAGLESON<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 9
RESEARCH<br />
ALFREDO REYES OLIVERAS<br />
FINDS WORLD OF POSSIBILITIES<br />
AT VAI GRADUATE SCHOOL<br />
Two years before Alfredo Reyes Oliveras came to Van Andel<br />
Institute Graduate School, he survived a hurricane.<br />
Reyes Oliveras was at home with family when Hurricane Maria<br />
struck Puerto Rico in September 2017. He and his family made it<br />
through, but the deadly Maria caused extreme damage and left<br />
millions without power for months.<br />
“I woke up during the night to get a glass <strong>of</strong> water and looked<br />
through the window. You could see trees falling,” Reyes Oliveras<br />
said. “The house in front <strong>of</strong> ours disappeared.”<br />
Despite the damage, Reyes Oliveras was able to return to his<br />
studies at University <strong>of</strong> Puerto Rico, Mayagüez Campus, relatively<br />
soon after; the university had escaped the brunt <strong>of</strong> the storm.<br />
He went on to earn two bachelor’s degrees: one in chemistry and<br />
another in molecular biology.<br />
Reyes Oliveras is part <strong>of</strong> VAI’s largest and most international<br />
Graduate School cohort to date. He learned <strong>of</strong> the Graduate<br />
School while researching programs in molecular biology.<br />
The Graduate School stood out from his other two considerations,<br />
Cornell University and University <strong>of</strong> Miami, because he viewed<br />
the Institute’s small size as an asset. “The Institute <strong>of</strong>fers a more<br />
welcoming experience,” Reyes Oliveras said. “You can know<br />
everybody here, and I really like that. You can make connections<br />
easily.”<br />
Reyes Oliveras is interested in further exploring cancer research<br />
at the Institute. His curiosity in the field was piqued during an<br />
undergraduate internship at University <strong>of</strong> Miami, where he studied<br />
pancreatic cancer.<br />
Though he leans toward pursuing cancer research, Reyes Oliveras<br />
had the opportunity to work on immune system research during a<br />
laboratory rotation with Dr. Connie Krawczyk his first semester. The<br />
research he saw impressed him and gave him something to think<br />
about in regard to his future track. Under the Graduate School’s<br />
curriculum, he’ll choose a thesis and select a research adviser in<br />
spring <strong>2020</strong> — his second semester.<br />
Just one semester in, Reyes Oliveras is already excited about the<br />
possibilities ahead.<br />
“The research at VAI is great,” he said, “and so far, I’ve only been<br />
exposed to a little bit <strong>of</strong> the science that’s happening here.”<br />
ALFREDO REYES OLIVERAS<br />
GRADUATE SCHOOL<br />
BY THE NUMBERS<br />
5.3 years average time to Ph.D.<br />
3 seven-week laboratory rotations during<br />
first two semesters<br />
3 years <strong>of</strong> doctoral candidate thesis<br />
research in a faculty mentor’s lab<br />
68% Ph.D. graduation rate<br />
75% total graduation rate (Ph.D. and M.D.)<br />
10 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
GRADUATE SCHOOL ‘A STEP ABOVE<br />
ALL THE OTHER PROGRAMS’ FOR<br />
DR. NIKKI THELLMAN<br />
For Dr. Nikki Thellman, earning a degree in veterinary<br />
medicine wasn’t enough.<br />
A self-described lifelong learner, she wanted to go beyond what<br />
she studied in vet school and tackle pressing problems in the clinic<br />
from a research perspective. “I was already a pr<strong>of</strong>essional with<br />
clinical experience and a vast understanding <strong>of</strong> disease diagnosis<br />
and treatment,” Thellman said. “What was missing was a deep<br />
understanding <strong>of</strong> the underlying mechanisms for disease and the<br />
scientific training to tackle unmet medical needs.”<br />
After four years <strong>of</strong> practicing veterinary medicine, Thellman<br />
researched doctoral programs. At a graduate school fair, she<br />
happened upon a booth for Van Andel Institute Graduate School.<br />
Intrigued by its mission and problem-based curriculum, she<br />
applied and was accepted.<br />
“I felt the Graduate School was unique and was truly a step above<br />
all the other programs,” Thellman said. “I would be building upon<br />
my skill sets and not just be another student number.”<br />
At the Institute, she joined the lab <strong>of</strong> Graduate School Dean<br />
Dr. Steven Triezenberg, whose research has greatly expanded<br />
understanding <strong>of</strong> how viruses “wake up” after lying dormant.<br />
Under Triezenberg’s mentorship, Thellman began studying herpes<br />
simplex virus, a common pathogen whose two types — herpes<br />
simplex virus type 1 and herpes simplex virus type 2 — collectively<br />
affect more than 4 billion people worldwide. Her task? To develop<br />
a laboratory tool growing sensory neurons in order to study the<br />
molecular and genetic factors that allow the virus to establish itself<br />
in a host, fall dormant and later reactivate.<br />
Thellman successfully defended her dissertation in 2017. She<br />
then spent two years as a clinical development manager at<br />
Zoetis, the largest animal health company in the world, running<br />
companion animal clinical trials for novel therapeutics. She recently<br />
transitioned to a senior scientist role there where she continues to<br />
blend her passions for veterinary medicine and scientific discovery<br />
to make a tangible impact on disease management.<br />
“Van Andel Institute Graduate School trained me to think like a<br />
scientist,” she said. “Everyone knows you and is eager to make your<br />
education experience a success.”<br />
For more information on Van Andel Institute Graduate School, visit<br />
vaigs.vai.org.<br />
DR. NIKKI THELLMAN<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 11
EDUCATION<br />
BLUE APPLE BRINGS PROJECT-BASED LEARNING TO LIFE<br />
The fifth-grade students at San Juan Diego Academy faced a<br />
choice: should they protect Earth’s environment or explore<br />
Mars as a potential home?<br />
The fifth-grade students at San Juan Diego Academy faced a<br />
choice: should they protect Earth’s environment or explore Mars<br />
as a potential home?<br />
The students were among the first to pilot a new program called<br />
Blue Apple, created by Van Andel Institute for Education to<br />
increase students’ engagement and help teachers who want to<br />
make a significant difference in their students’ lives. Blue Apple<br />
provides teachers with project plans and supplies, connections to<br />
real-world experts, cross-curricular content, and the opportunity<br />
to collaborate with other classrooms. The Institute also makes<br />
members <strong>of</strong> its staff available as project coaches.<br />
“Working with VAI is just something special for us, and we are<br />
really blessed,” said Christine Wright, a fifth-grade teacher at San<br />
Juan Diego Academy. “If the Institute did not work with us and<br />
give us these opportunities, there would be experiences our<br />
students would miss out on.”<br />
Wright’s students undertook Blue Apple’s “Dirty Truth” project,<br />
and learned the importance <strong>of</strong> protecting Earth’s environment<br />
and researched the potential <strong>of</strong> life on Mars. They studied soils<br />
and fertilizers to grow crops, and filmed commercials to raise<br />
money for their causes.<br />
The class divided into two teams — the Red Team for Mars, the<br />
Blue Team for Earth — researched each option, and then taped<br />
commercials urging people to donate for their causes. For the<br />
students — most <strong>of</strong> them the children <strong>of</strong> recent immigrants from<br />
Mexico, Central America and South America — the exercise was an<br />
engaging, cross-curricular exercise combining English language<br />
arts, math, science, social studies, and social-emotional learning.<br />
The Red Team raised $205 and donated it to Students for the<br />
Exploration and Development <strong>of</strong> Space. The Blue team raised $188<br />
and donated it to the Environmental Defense Fund.<br />
Blue Apple, which launched in 2019, has been adopted by more<br />
than 200 schools throughout the Midwest and beyond. Teachers<br />
who have used Blue Apple projects have been very happy with how<br />
their students became engaged and enthusiastic about learning.<br />
“It’s always been a part <strong>of</strong> our mission to impact education on a<br />
national scale. We think Blue Apple is a productive way to do it.<br />
The project really is built around the idea that engagement leads<br />
to achievement,” said Terra Tarango, VAI’s chief education <strong>of</strong>ficer.<br />
“We’re really pleased that 100 percent <strong>of</strong> the teachers said it<br />
increased critical and creative thinking among their students.”<br />
For more information about Blue Apple, visit blueappleteacher.org.<br />
SAN JUAN DIEGO ACADEMY STUDENTS<br />
ENGAGING WITH BLUE APPLE<br />
12 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAI SUMMER CAMPS<br />
HOW VAI SUMMER CAMPS NURTURE A FAMILY’S LOVE OF LEARNING<br />
Ceci Kovarik, a lively 9-year-old, recently took a trip to Mars.<br />
Ceci attended “Mission to Mars,” one <strong>of</strong> VAI’s summer camps,<br />
where she was able to explore the science, engineering and<br />
technology needed to complete a trip to another planet.<br />
Along with students from West Michigan, Ceci made new friends,<br />
developed an understanding <strong>of</strong> scientific concepts and embraced<br />
her boundless curiosity.<br />
Ceci’s mother, Joanna, is a Polish immigrant who met her husband,<br />
originally from the Czech Republic, on a flight from Prague to<br />
Chicago. After they got married, the couple settled on the north<br />
side <strong>of</strong> Grand Rapids, where they are raising six children together.<br />
Kovarik believes that her children’s future and their success lies in<br />
the power <strong>of</strong> knowledge. “I understood that one <strong>of</strong> the best ways<br />
you can advance yourself in this country is through education, so I<br />
always encourage our kids to work hard and do the best they can,”<br />
Joanna said. Joanna learned about VAI’s educational programs from<br />
a teacher at their middle school, and the recommendation helped<br />
shape the trajectory <strong>of</strong> her children’s lives.<br />
“The Institute really opened up the kids’ horizons and enabled them<br />
to work with students from other schools who were also passionate<br />
about science and focused on learning,” Joanna said. “The kids<br />
involved in these programs are so empowered to learn, and the<br />
teachers really help them view what they are doing as important<br />
and valuable.”<br />
JOANNA, LUCIE & CECI KOVARIK<br />
Lucie Kovarik, a sophomore in high school with a passion for<br />
science, also participated in VAI’s summer camps. She enjoyed the<br />
opportunity to meet like-minded students and explore her interests<br />
so much that she has attended the camp for the past three years.<br />
“I am always looking for opportunities to learn, and I really love the<br />
diversity <strong>of</strong> science,” Lucie said. “When you’re a scientist, there’s just<br />
so much out there to explore.”<br />
Joanna is grateful her children were able to participate in VAI’s<br />
education programs and hopes the Institute will continue to expand<br />
on education initiatives that have given her children such wonderful<br />
opportunities to experience the joy <strong>of</strong> learning, explore new<br />
interests and discover the world.<br />
“I credit Van Andel Institute for a lot <strong>of</strong> my kids’ success in school,”<br />
Joanna said. “It’s worth the commitment, and when you don’t have<br />
access to very many educational resources, a program like this<br />
really means a lot.”<br />
For information on Van Andel Institute’s student programs, visit<br />
vaei.org/student-programs.<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 13
EVENTS<br />
CURIOSITY HOUR<br />
Parents and children got the chance to rekindle their<br />
childhood during Curiosity Hour. Guests explored Van Andel<br />
Institute’s animal habitats, observed science demonstrations<br />
and engaged in hands-on science challenges. The family-focused<br />
event highlighted the many ways VAI is creating classrooms where<br />
curiosity, creativity and critical thinking thrive.<br />
(STARTING AT THE TOP LEFT, GOING CLOCKWISE) KIDS EXPERIMENT WITH FOSSILS AT THE CAN YOU DIG IT STATION;<br />
GUESTS COOL DOWN AT THE KONA ICE TRUCK; TOBY THE TORTOISE IN HER HABITAT; KIDS THINK LIKE ENGINEERS TO BUILD STABLE STRUCTURES;<br />
TESTING STRUCTURE DESIGNS AT THE SHAKE, SHAKE, SHAKE STATION<br />
14 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAI GOLF OUTING<br />
Golfers, donors and Van Andel Institute supporters gathered<br />
for a day <strong>of</strong> fundraising and fun during the Institute’s 12th<br />
annual VAI Golf Outing. Held at the beautiful Wuskowhan Players<br />
Club in West Olive, Michigan, guests enjoyed 18 holes on a beautiful<br />
course, lunch, and a dinner and awards presentation featuring<br />
special guest, hockey player and philanthropist Mike Knuble.<br />
Thank you to the Title Sponsor: The Veldheer, Long, Mackay &<br />
Bernecker Group <strong>of</strong> Merrill Lynch.<br />
(STARTING AT THE TOP LEFT, GOING CLOCKWISE) JACK DOLES, MIKE KNUBLE, DAVID VAN ANDEL & KYLE VAN ANDEL; THE TITLE SPONSOR GROUP<br />
ENJOYING THE DAY; CAROL VAN ANDEL & SUSAN SHAW; SPECIAL GUEST MIKE KNUBLE DISCUSSES THE IMPORTANCE OF THE INSTITUTE’S MISSION;<br />
THE SILENT AUCTION TABLE FEATURING A VARIETY OF RED WINGS MERCHANDISE SIGNED BY MIKE KNUBLE<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 15
EVENTS<br />
COUTURE FOR A CURE<br />
Fashionistas from across West Michigan joined Van Andel<br />
Institute for the 14th annual Couture for a Cure. This year’s<br />
event featured a fashion presentation by Leigh’s, and a runway<br />
show featuring designer Victoria Hayes Fall/Winter ’19 collection,<br />
as well as an Amway Artistry beauty lounge and strolling appetizers<br />
and cocktail stations.<br />
Thank you to the Presenting Sponsor: Leigh’s; and the Title<br />
Sponsor: Amway.<br />
(STARTING AT THE TOP LEFT, GOING CLOCKWISE) THE ARTISTRY BEAUTY LOUNGE FEATURING HAIR & MAKEUP TOUCHUPS; GUESTS ENJOY AN<br />
EXCLUSIVE LOOK AT VICTORIA HAYES’ FALL/WINTER ‘19 COLLECTION; CAROL VAN ANDEL SHARES THE INSTITUTE’S LASTEST RESEARCH UPDATES<br />
16 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
(STARTING AT THE TOP LEFT, GOING CLOCKWISE) AMWAY’S CANDACE MATTHEWS EMCEES THE EVENT; A MODEL WALKS THE RUNWAY; FEATURED<br />
DESIGNER VICTORIA HAYES, LEIGH’S OWNER REBECCA WIERDA, SCOTT WIERDA & LEIGH’S SALES MANAGER JOANNA HADJIYANIS;<br />
CAROL VAN ANDEL WITH JANE ZWIERS & YOUNG SUPPORTERS OF THE INSTITUTE FROM HOPE COLLEGE<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 17
EVENTS<br />
HOPE ON THE HILL GALA —<br />
A NIGHT IN WONDERLAND<br />
Hundreds <strong>of</strong> guests joined Alice, the Mad Hatter, Queen <strong>of</strong><br />
Hearts and Tweedle Dum and Dee for Van Andel Institute’s<br />
<strong>Hope</strong> on the Hill Gala — A Night in Wonderland. Guests enjoyed<br />
gourmet cuisine from Grand Rapids’ finest restaurants, artisan<br />
cocktails served on hand-carved bars <strong>of</strong> chiseled ice, an uproarious<br />
magical performance from Piff the Magic Dragon, and a dance<br />
party hosted by AB.<br />
Thank you to the Title Sponsor: Fifth Third Private Bank.<br />
(STARTING AT THE TOP LEFT, GOING CLOCKWISE) JEFFERY ROBERTS, CAROL VAN ANDEL & DAVID VAN ANDEL; GUESTS BID ON<br />
EXCITING PACKAGES AT THE SILENT AUCTION TABLE; PIFF THE MAGIC DRAGON ENTERTAINS THE AUDIENCE WITH HIS UNIQUE<br />
PERFORMANCE; CO-CHAIRS OF VAI’S JBOARD AMBASSADORS, CHAD BASSETT & RACHEL MRAZ;<br />
GUESTS DANCE THE NIGHT AWAY IN WONDERLAND<br />
18 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
(STARTING AT THE TOP LEFT, GOING CLOCKWISE) THE MAD HATTER ENTICING GUESTS TO A TEA PARTY; VAI’S DR. HEIDI LEMPRADL ENJOYS A<br />
CARD TRICK; THE CHESHIRE CAT SMILES AT GUESTS AS THEY CELEBRATE THE EVENING; WONDERFULLY DELICIOUS DESSERTS<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 19
EVENTS<br />
A CONVERSATION ABOUT<br />
METABOLISM AND NUTRITION—<br />
HOSTED BY CAROL VAN ANDEL<br />
A Conversation About Metabolism and Nurition — Hosted by<br />
Carol Van Andel placed a powerful spotlight on the Institute’s<br />
exciting new research into how metabolism and nutrition<br />
can play a role in diseases like cancer and Parkinson’s.<br />
During this informative event, VAI’s Dr. Russell Jones and Dr. Connie<br />
Krawczyk provided information on their research, and how these<br />
biological functions can both prevent and proliferate disease.<br />
The two esteemed scientists also answered questions from those<br />
in attendance.<br />
Thank you to the Title Sponsor: Howard Miller.<br />
(STARTING AT THE LEFT, GOING CLOCKWISE) DR. RUSSELL JONES, DR. CONNIE KRAWCZYK & WOOD TV’S MARANDA; CAROL VAN ANDEL<br />
HOSTING THE EVENT; GUESTS NETWORK BEFORE THE EVENT; VAI’S CHIEF SCIENTIFIC OFFICER DR. PETER A. JONES MINGLING WITH GUESTS<br />
20 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAI PUBLIC LECTURE: A FOCUS<br />
ON TRANSLATIONAL MEDICINE<br />
Taking scientific discoveries from the lab to the doctor’s <strong>of</strong>fice<br />
requires a complex system <strong>of</strong> testing and trials. Translational<br />
medicine is an important area <strong>of</strong> research which aims to better<br />
understand scientific discoveries that might be beneficial to human<br />
health. Guests attending A Focus on Translational Medicine learned<br />
how data from basic research and clinical trials is translated into new<br />
diagnostics and therapies that might one day benefit patients.<br />
Dr. Matt Steensma, a scientific investigator in the Institute’s Center<br />
for Skeletal Disease Research, and Dr. Stephen Baylin, co-leader <strong>of</strong><br />
the Van Andel Institute–Stand Up To Cancer Epigenetics Dream<br />
Team, both presented their work and answered questions during<br />
this research-focused event.<br />
VAI PUBLIC LECTURE: A FOCUS ON<br />
EDUCATION IN AMERICA<br />
Our world is changing rapidly — new technologies, access<br />
to information and the demands <strong>of</strong> the modern workforce<br />
present students and teachers with an impressive amount<br />
<strong>of</strong> challenges. Van Andel Institute’s chief education <strong>of</strong>ficer, Terra<br />
Tarango, presented the various ways the Institute is creating<br />
classrooms where students are prepared to meet the challenges<br />
<strong>of</strong> the 21st century during A Focus on Education in America. Guests<br />
learned about Common Core Standards, standards-based<br />
grading practices, project-based learning and new ways to create<br />
classrooms that are filled with engaged learners.<br />
(STARTING AT THE LEFT, GOING CLOCKWISE) BRETT HOLLEMAN, DR. MATT STEENSMA & DR. STEPHEN BAYLIN;<br />
TERRA TARANGO; GUESTS PARTICIPATE IN AN INTERACTIVE DISCUSSION<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 21
EVENTS<br />
THANK YOU TO OUR GENEROUS EVENT SPONSORS<br />
To learn more about sponsoring an event, contact Sarah Rollman at sarah.rollman@vai.org.<br />
VAI Golf Outing<br />
Dennis & Barbara Adama<br />
Applied Imaging<br />
Custer Inc.<br />
Erhardt Construction<br />
First National Bank<br />
Gallagher Insurance<br />
Grand Rapids Christian Schools<br />
Ben & Molly Hunting<br />
iHeart Media<br />
Life EMS Ambulance<br />
Macatawa Bank<br />
Making the Turn Against Parkinson’s<br />
Merrill Lynch — Veldheer, Long, Mackay &<br />
Bernecker Group<br />
Metro Health — University <strong>of</strong><br />
Michigan Health<br />
Midwest Capital Advisors, LLC<br />
Pine Rest<br />
Priority Health<br />
Regal Financial Group LLC.<br />
Rockford Construction<br />
John & Therese Rowerdink<br />
Secrest Wardle<br />
Summit Point Ro<strong>of</strong>ing<br />
The John Dykema & Michele Maly-Dykema<br />
Family Foundation<br />
The Sharpe Collection<br />
Thomas & Mary Stuit<br />
US Bank<br />
Dave & Beth Van Portfliet<br />
Brian & Lori Vander Baan<br />
Wells Fargo<br />
Wells Fargo Advisors<br />
West Michigan Woman<br />
Zip Xpress, Inc.<br />
Couture for a Cure<br />
Amway<br />
Bengtson Center for Aesthetics &<br />
Plastic Surgery<br />
Franco & Alessandra Bianchi<br />
Chuck & Christine Boelkins<br />
Cheeky Strut<br />
Consumers Credit Union<br />
Mimi Cummings<br />
Cumulus<br />
CWD Real Estate Investment<br />
David & Carol Van Andel Family Foundation<br />
Deloitte<br />
Brian DeVries & Barbara Pugh<br />
Divani<br />
Eileen DeVries Family Foundation<br />
Eurest<br />
First National Bank<br />
Gallagher Insurance<br />
Jana Hall<br />
Kurt & Madelon Hassberger<br />
Paul & Sheryl Haverkate<br />
Dave & Donna Hockstra<br />
Bill & Starr Humphries<br />
Jandernoa Foundation<br />
Jeffery Roberts Design<br />
Dr. Peter & Veronica Jones<br />
Lake Michigan Credit Union<br />
McAlvey Merchant & Associates<br />
Deb Meijer<br />
Mercy Health<br />
Modern Day Collective<br />
Nothing Bundt Cakes<br />
Tom & Brenda Rinks<br />
Scott Group Studio<br />
The Steve & Amy Van Andel Foundation<br />
Todd Wenzel Automotive<br />
Townsquare Media<br />
Sharon Van Dellen<br />
Mike & Bonnie Walters<br />
West Michigan Woman<br />
Wheelhouse Kitchen & Cocktails<br />
Greg & Meg Willit<br />
Jim & Jane Zwiers<br />
<strong>Hope</strong> on the Hill<br />
Amway<br />
Amway Grand Plaza Hotel<br />
Anonymous<br />
Aon<br />
Aquinas College<br />
Autocam Medical<br />
Betz Industries<br />
BHS Insurance<br />
Dave & Jill Bielema<br />
Bluewater Technologies<br />
Chuck & Christine Boelkins<br />
BRAVO<br />
Buist Electric<br />
Butcher’s Union<br />
Jerry & Suzanne Callahan<br />
Cancer & Hematology Centers <strong>of</strong><br />
Western Michigan<br />
Cascade Rental<br />
Center for Physical Rehabilitation<br />
CityFlatsHotel<br />
Colliers International<br />
Crowe LLP<br />
Cumulus Media<br />
Tom & Tracy Curran<br />
Custer Inc.<br />
Davenport University<br />
David & Carol Van Andel Family Foundation<br />
Deloitte<br />
Divani<br />
Jeff & Mary Dixon<br />
Eenhoorn, LLC<br />
Ellis Parking Company<br />
Erhardt Construction<br />
Ferris C<strong>of</strong>fee & Nut Co.<br />
Fifth Third Bank<br />
Foremost Insurance Company<br />
Fred L. Hansen Corporation<br />
Gallagher Insurance<br />
Grand Valley State University<br />
Martin & Peggy Greydanus<br />
Kurt & Madelon Hassberger<br />
HealthBridge<br />
<strong>Hope</strong> College<br />
<strong>Hope</strong> Network<br />
Howard Miller<br />
Huizenga Group<br />
Ice Sculptures, LTD<br />
ICN Foundation<br />
iHeart Media<br />
Independent Bank<br />
Jandernoa Foundation<br />
Julie & Dan Horning Family FUN’d<br />
Craig & Debra Kinney<br />
Kitchen 67<br />
Al & Robin Koop<br />
Blake & Mary Krueger<br />
Lake Michigan Credit Union<br />
Ray & Jeannine Lanning<br />
Leo’s<br />
Lighthouse Group<br />
Gary & Vicky Ludema<br />
Macatawa Bank<br />
McAlvey Merchant & Associates<br />
Mercy Health<br />
Merrill Lynch — The Veldheer, Long,<br />
Mackay & Bernecker Group<br />
Metro Health<br />
22 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Michelle Crumback Jewelry<br />
Michigan State University College <strong>of</strong><br />
Human Medicine<br />
MLive Media Group<br />
Modern Day Collective<br />
New Holland Brewing<br />
Norris Perne & French, LLP<br />
Nothing Bundt Cakes<br />
Orthopaedic Associates <strong>of</strong> Michigan<br />
Owens-Ames-Kimball Co.<br />
Peter C. & Emajean Cook Foundation<br />
Pioneer Construction<br />
Pitsch Company<br />
Plastic Surgery Associates<br />
Priority Health<br />
Quality Air Service, Inc.<br />
Rehmann<br />
Reserve Wine & Food<br />
Rockford Construction<br />
Eve Rogus & Paul Becker<br />
Rowerdink Inc.<br />
Tony & Dawn Semple<br />
Slows Bar BQ<br />
Spectrum Health<br />
Rob & Susan Stafford<br />
Steelcase<br />
Stephen Klotz Family Foundation<br />
Sweetie-licious Bakery<br />
Taconic Charitable Foundation<br />
Terra<br />
The Chop House<br />
The Meijer Foundation<br />
The Sharpe Collection<br />
The Steve & Amy Van Andel Foundation<br />
Thomas S. Fox Family<br />
Townsquare Media<br />
US Bank<br />
Mike & Michelle Van Dyke<br />
Van Eerden Food Service Company<br />
Warner Norcross + Judd LLP<br />
Wells Fargo<br />
West Michigan Woman<br />
Wheelhouse Kitchen & Cocktails<br />
Greg & Meg Willit<br />
Wolverine Worldwide<br />
Women’s Lifestyle<br />
Jim & Jane Zwiers<br />
A Conversation About Metabolism<br />
Hosted by Carol Van Andel<br />
Cornerstone University<br />
Gallagher Insurance<br />
Howard Miller<br />
iHeart Media<br />
Jana Hall<br />
Kent County Medical Society Alliance<br />
Leigh’s<br />
Townsquare Media<br />
West Michigan Woman<br />
Dr. Bart & Wendy Williams<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 23
PURPLE COMMUNITY<br />
STUDENTS HONE LEADERSHIP SKILLS AT VAI PURPLE<br />
COMMUNITY LUNCH & LEARN<br />
Katie Tietema first heard about the<br />
Van Andel Institute Purple Community<br />
Leadership Lunch & Learn when a<br />
representative from VAI reached out<br />
to St. Paul the Apostle School, where<br />
Tietema works.<br />
Tietema was immediately intrigued by the<br />
event, which brings together dozens <strong>of</strong><br />
students and educators to learn about the<br />
biomedical research and science education<br />
initiatives happening at VAI. Tietema helped<br />
assemble a group <strong>of</strong> 70 students and<br />
teachers to attend.<br />
“Every single student we brought knows<br />
someone in their family or has a close<br />
friend who has been impacted by one <strong>of</strong> the<br />
diseases being studied at VAI,” Tietema said.<br />
“It’s sad but true, and it makes the Institute’s<br />
mission very relevant to our students.”<br />
The October 2019 PC Lunch & Learn was<br />
the Institute’s fourth annual and the first<br />
to be open to all schools. Approximately<br />
180 students and educators attended, the<br />
largest group in the event’s history.<br />
Attendees were welcomed by WOOD-TV’s<br />
Maranda, who emceed the event. Groups<br />
were given tours <strong>of</strong> Van Andel Institute<br />
for Education’s lab nearby, where chief<br />
education <strong>of</strong>ficer Terra Tarango explained<br />
the Institute’s work and how her team<br />
creates classrooms where curiosity,<br />
creativity and critical thinking thrive.<br />
Students even participated in hands-on<br />
experiments.<br />
WEST MICHIGAN STUDENTS LUNCH & LEARN WITH PURPLE COMMUNITY<br />
Dr. Payton Stevens, a postdoctoral fellow<br />
in the lab <strong>of</strong> Dr. Bart Williams, hosted<br />
a discussion with attendees about the<br />
biomedical research being done at the<br />
Institute. Stevens shared with students how<br />
community support helps scientists at VAI<br />
pursue breakthroughs that may improve<br />
outcomes for patients with diseases like<br />
Parkinson’s and cancer.<br />
Tietema and her group were so impressed<br />
by the event that they decided to partner<br />
with Purple Community for St. Paul the<br />
Apostle’s annual Parish 5K & Festival<br />
fundraiser. Tietema said teachers at the<br />
school also plan to attend future Lunch &<br />
Learn events. This year will be the first time<br />
the Institute will host two Lunch & Learn<br />
events; one is in March and another in<br />
October.<br />
“Our students were so excited and asked so<br />
many great questions during the PC Lunch<br />
& Learn,” she said. “It was great to see how<br />
engaged and interested they were.”<br />
To learn more about Van Andel Institute Purple<br />
Community events, visit purplecommunity.org.<br />
24 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 25
PHILANTHROPY<br />
DR. JUAN OLIVAREZ, DONOR<br />
AND TRUSTEE, IS INSPIRED TO<br />
MAKE A DIFFERENCE<br />
Dr. Juan Olivarez discovered the value <strong>of</strong><br />
education early in life, and he has been<br />
helping others learn ever since.<br />
“I had a brother with Down syndrome,<br />
and when we were growing up, I was his<br />
protector and teacher,” Olivarez said. “I<br />
always loved being there for him and feeling<br />
like I was helping him learn something new.”<br />
medicine, research and education. This<br />
place is a miracle.”<br />
Olivarez and his son both fought battles<br />
against cancer, and this personal<br />
connection to the Institute’s research has<br />
given him a special perspective regarding<br />
the importance <strong>of</strong> science, awareness and<br />
discoveries that can impact human lives.<br />
A former teacher and clinical psychologist,<br />
an accomplished university administrator<br />
and a generous philanthropist, Olivarez has<br />
supported Van Andel Institute’s mission and<br />
education initiatives since 2008, both as a<br />
board member and a donor. While serving<br />
as president <strong>of</strong> Grand Rapids Community<br />
College, Olivarez met David and Carol<br />
Van Andel. He was inspired by their passion<br />
for biomedical research and science<br />
education and became interested in the<br />
Institute they helped found.<br />
“I knew Carol from working with her on<br />
philanthropic events, and when David asked<br />
me to join the Board <strong>of</strong> Trustees for<br />
Van Andel Institute for Education, I proudly<br />
and enthusiastically accepted,” he said. “I<br />
knew from the beginning that the Institute<br />
is a gem in our community and how very<br />
lucky we are to have it here.”<br />
Having lived in Grand Rapids for more than<br />
48 years, Olivarez is amazed by the impact<br />
VAI has had on the region and the city he<br />
and his wife, Mary, call home.<br />
“There is no doubt the establishment <strong>of</strong> the<br />
Institute in 1996 is a marker for a shift in<br />
the city’s skyline, as well as the education<br />
and research infrastructure <strong>of</strong> Grand<br />
Rapids,” Olivarez said. “It’s really hard to<br />
believe everything the Institute has done<br />
in such a short amount <strong>of</strong> time — what<br />
started as the Van Andel family’s dream is<br />
now a national and international hub for<br />
“It’s really hard to believe<br />
everything the Institute has<br />
done in such a short amount<br />
<strong>of</strong> time — what started as<br />
the Van Andel family’s<br />
dream is now a national<br />
and international hub for<br />
medicine, research and<br />
education. This place is a<br />
miracle.”<br />
— DR. JUAN OLIVAREZ<br />
“As a survivor and a person whose family<br />
has been affected by cancer, I am well<br />
aware that we need better treatments and<br />
cures. I also know that if we can continue<br />
to support research with discipline and<br />
tenacity, we will one day find them.”<br />
Join Dr. Olivarez and become a VAI donor<br />
today. Contact Brett Holleman at brett.<br />
holleman@vai.org to learn how you can<br />
support the Institute’s scientists in their<br />
fight against cancer, Parkinson’s and<br />
other diseases.<br />
DR. JUAN & MARY OLIVAREZ<br />
26 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 27
PHILANTHROPY<br />
HOW VAN ANDEL INSTITUTE PURPLE COMMUNITY<br />
HELPS MAKE FUNDRAISING EVENTS A HIT<br />
For 13 years, Pat Ringnalda has been<br />
hosting the Bee Brave 5K to raise money<br />
for breast cancer research. Organizing<br />
the event is a heavy lift, but for the last<br />
three years, that work has been made<br />
easier with help from Van Andel Institute<br />
Purple Community.<br />
Bee Brave, which celebrated its 12th run<br />
in 2019, began partnering with Purple<br />
Community after Ringnalda attended a golf<br />
outing to benefit VAI’s scientific research.<br />
Ringnalda was impressed by the support<br />
Purple Community gives its community<br />
and corporate partners to carry out<br />
such events. The more she learned, the<br />
more she realized the Bee Brave 5K would<br />
benefit greatly from partnering with Purple<br />
Community.<br />
“I have <strong>of</strong>ten said, if God gives you the<br />
nerve to ask people for money to support<br />
great causes, do it!” Ringnalda said. “You<br />
start with the best institutions like VAI,<br />
because they will give you the tools and<br />
support you need to be successful in your<br />
efforts.”<br />
The Bee Brave 5K is one <strong>of</strong> dozens <strong>of</strong><br />
community events hosted each year to<br />
benefit scientific research and education<br />
programs at the Institute. Many people who<br />
organize these events begin by wanting to<br />
donate to a good cause, but are unsure<br />
how to get started.<br />
Purple Community makes it easy using an<br />
online application that outlines each event’s<br />
needs such as expected event location, size<br />
and fundraising goal. Once the application<br />
is received, it’s reviewed to determine how<br />
Purple Community can best support the<br />
event. Examples include setting up online<br />
fundraising portals, designing event fliers<br />
and more.<br />
“Community events are an essential part <strong>of</strong><br />
supporting the important work happening<br />
at VAI,” said Purple Community volunteer<br />
coordinator McKenzie Hollern. “We want<br />
our organizers to know how much we<br />
appreciate their efforts by <strong>of</strong>fering our full<br />
support and resources to make their events<br />
a success.”<br />
To learn more, visit purplecommunity.org.<br />
PAT RINGNALDA (RIGHT)<br />
28 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
KAY KOO HONORS FAMILY LEGACY OF GIVING<br />
When Kay Koo and her husband,<br />
Dr. Han-Mo Koo, arrived in Grand<br />
Rapids from Maryland in 1999, the<br />
city’s downtown was a sparse collection<br />
<strong>of</strong> shuttered businesses, fast food<br />
restaurants and a few beautiful, old<br />
churches. There was not, however, a<br />
research institute back then. Dr. Koo was<br />
one <strong>of</strong> the first scientists asked by Dr.<br />
George Vande Woude, a cancer research<br />
pioneer and Van Andel Institute’s first<br />
director <strong>of</strong> research, to help build<br />
Van Andel Institute from the ground up.<br />
“I feel a connection with what my husband<br />
started 20 years ago,” Koo said. “The<br />
Institute has my heart, and I hope we<br />
continue to grow and come up with new<br />
therapies for diseases that affect the lives<br />
<strong>of</strong> our loved ones. I really think my husband<br />
would be proud <strong>of</strong> what the Institute has<br />
become.”<br />
“We came here because we respected the<br />
work <strong>of</strong> Dr. Vande Woude, and even though<br />
there was not a lot going on in Grand<br />
Rapids at the time, we knew it would be<br />
exciting to be part <strong>of</strong> something new that<br />
didn’t exist yet,” Koo said.<br />
Dr. Koo served as head <strong>of</strong> the Institute’s<br />
Laboratory <strong>of</strong> Cancer Pharmacogenetics<br />
until he lost a six-month battle with<br />
cancer in 2004. His work focused on the<br />
identification <strong>of</strong> genetic targets for anticancer<br />
drug development for melanoma<br />
and pancreatic cancer. He was also<br />
an active contributor to the Institute’s<br />
Employee Impact Campaign that supported<br />
his fellow scientists. After his passing, Koo<br />
began working at the Institute as Dr. Vande<br />
Woude’s administrative assistant. Like<br />
her husband, Koo continued their family’s<br />
legacy <strong>of</strong> generosity as an employee donor.<br />
“I come from a family <strong>of</strong> giving. I grew up as<br />
the daughter <strong>of</strong> a pastor in a family where<br />
giving <strong>of</strong> yourself was just so natural,” Koo<br />
said. “I give to honor my husband’s memory<br />
and to support the people who helped me<br />
when he was so sick.”<br />
Koo recently surpassed her 15th year as<br />
a VAI employee, and after a decade and a<br />
half <strong>of</strong> service to the mission, the Institute<br />
is more than a place to work — it’s a family.<br />
KAY KOO<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 29
PHILANTHROPY<br />
MEMORIALS<br />
We appreciate your trust in us to fight disease in memory or in honor <strong>of</strong><br />
your family and friend s — with hope for a healthier tomorrow. To make a<br />
gift in memory or honor <strong>of</strong> a loved one, please call 616.234.5552.<br />
Alison “Awesome Ali”<br />
Aardema<br />
Steven & Julie Aardema<br />
Shirley Alt<strong>of</strong>t<br />
James & Frieda Jaynes<br />
Lorrie Jaynes<br />
Dominic “Nick” Amante<br />
Gerald & Mary McDermott<br />
Robert Anderson<br />
David & Lynne Robinson<br />
Jean Atkinson<br />
David & Patti Atkinson<br />
David Barney<br />
Bruce & Carolyn Tuttleman<br />
Keith Bassett<br />
Jean Bassett<br />
Jeanne Bergsma<br />
Jean Swaney<br />
James Breay<br />
David Solis<br />
Chester Bush<br />
David & Carol Van Andel<br />
Family Foundation<br />
Robert Bylenga<br />
William & Jackie Bylenga<br />
Peter Bylsma<br />
Carol Bylsma<br />
Frank Campbell<br />
Paul & Lynn Getzin<br />
Robert Campbell<br />
Jean Swaney<br />
David Christie<br />
Roxanne Anderson<br />
Elizabeth Cobb<br />
Jean Swaney<br />
Patti Ditmar<br />
Florence Barrett<br />
Jack & Rhonda Barrett<br />
Rod & Kerri Brandsen<br />
Joseph & Suzanne Dahms<br />
Lois Dickinson<br />
Ryne & Julie Dickinson<br />
Jan Hall<br />
Stephen Heneveld<br />
Steve & Linda Kammeraad<br />
Joel & Karlene Krause<br />
Maureen Dobson<br />
Lake Michigan Dental<br />
Peerless Steel<br />
John & Lisa Wilson<br />
Kathleen Drennan<br />
Brock & Katie Plumb<br />
Robert DuHadway<br />
Richard & Terri MacKeigan<br />
Bill & Linda Peterson<br />
Terry & Laura Reese<br />
John & Judith Wavro<br />
David & Deborah Wurfel<br />
Mary Kate (Katie) Dutcher<br />
Daniel & Mona Morgan<br />
Sam Smits & Edith<br />
Wehrly-Smits<br />
Katherine Williams<br />
Melissa Eden<br />
Keith & Carolyn Murphy<br />
Charles Emmerich<br />
Charles & Nancy Emmerich<br />
Douglas & Nancy Knobloch<br />
Todd & Cynthia Ross<br />
Patrick & Sue Van Duinen<br />
Francine Erb<br />
Wally & Nina Gorak<br />
Bernard Forystek<br />
James & Kimberle Johnson<br />
Fredrick Gleason<br />
David Bevins<br />
Timothy Haak<br />
Mary Haak<br />
Gisela Kah<br />
JoAnn Crary<br />
Dixie Anderson<br />
David & Carol Van Andel<br />
Family Foundation<br />
The Dick & Betsy DeVos<br />
Family Foundation<br />
Fifth Third Bank<br />
Dan & Lou Ann Gaydou<br />
Gerald R. Ford International<br />
Airport<br />
Greg Northrup & Birgit Klohs<br />
Horst & Margot Lach<br />
Michigan State University<br />
College <strong>of</strong> Human Medicine<br />
Jon Nunn<br />
The Right Place, Inc.<br />
Ulrich & Martina Schlagwein<br />
Doug Small<br />
Robert Spohr<br />
Jim Teets<br />
Terryberry Company LLC<br />
Mark Kastner<br />
Brenda Kastner<br />
Nathanael Kastner<br />
Frank Krhovsky<br />
James & Florence Bouwman<br />
Renee Kuipers<br />
Gordon & Mary Buitendorp<br />
Sue Chavron<br />
Frank & Kerrie Doezema<br />
Bruce & Esther Drukker<br />
Carl & Sandy Gronsman<br />
Lake Michigan Dental<br />
Evan & Lois Reinders<br />
Sanford Leestma<br />
David & Linda Male<br />
Irma Leonard<br />
Joseph & Margaret Biersack<br />
Victor Leslie<br />
Jean Swaney<br />
Michelle Lunn<br />
Michelle Lunn <strong>Hope</strong><br />
Foundation<br />
Jane McConnell<br />
Memorial Alternatives<br />
Philip McCorkle<br />
David & Carol Van Andel<br />
Family Foundation<br />
John Moliassa<br />
Matt & Robin Dhaseleer<br />
John & Ann Moliassa<br />
Charlotte Mulder<br />
Roger & Beverly Mulder<br />
Bruce O’Connor<br />
Wally & Nina Gorak<br />
Thomas Peterson<br />
Anonymous<br />
Michael & Barbara Corey<br />
Jody Davis<br />
Stephen & Lynne Kindy<br />
Erik & Sally Klimek<br />
Debra Landers<br />
Jan London<br />
Eric & Ruth McClure<br />
Michelle Oole<br />
Mark & Jill Smith<br />
Denise Picardat<br />
Brian & Denise Picardat<br />
James Ponitz<br />
Kathleen Ponitz<br />
Jean Prose<br />
Wally & Nina Gorak<br />
Richard Pullen<br />
Ruth Kemp<br />
Neda Raterink<br />
Gary & Neda Raterink<br />
Rose Ray<br />
Eugene & Barbara Gutting<br />
David L. Rossi<br />
Anne Rossi<br />
John & Lucille Ryan<br />
Donald & Patricia Patterson<br />
Amy Schneider<br />
JoEllen Schneider<br />
Rajindeer Singh<br />
Puneet Chowdhary<br />
Cynthia Smith<br />
Christa Cook<br />
Daniel & Evelyn Preston<br />
Larry & Barbara Smith<br />
Doug & Maryln Walton<br />
Keith Smith<br />
Carol Smith<br />
Ben Snoeyink<br />
Baker Perkins, Inc.<br />
Dale & Phyllis de Longpre<br />
Allen & Vivian DeJonge<br />
Gary & Terri Dewey<br />
Mark & Donna Dezwarte<br />
Frank & Kerrie Doezema<br />
Timothy & Kristin Gabrielse<br />
Carl & Sandy Gronsman<br />
Curtis & Kristine Hancock<br />
Laura Palsrok<br />
Jay & Beverly Pruim<br />
Burton & Phyllis Rozema<br />
The Rozema Family Fund<br />
Marianne Stehouwer<br />
Robert & Marjorie Stuit<br />
Eric & Pat Symanski<br />
Dean & Carol Vanbruggen<br />
Charlotte Stein<br />
Keith & Theresa Kiel<br />
Susan Suwyn<br />
Scott Cavanaugh<br />
Ronald Swiderek<br />
Ronald & Alice Swiderek<br />
Daniel Terwee<br />
Brian & Dianne Boelens<br />
Fred & Doris Mowery<br />
Lewis & Nancy Travis<br />
Donald Van Artsen<br />
Timothy & Terri Blanch<br />
Sydney Edlund<br />
Jon & Mary Forslund<br />
William & Marilyn Lundquist<br />
30 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
TRIBUTES<br />
(Donald Van Artsen cont.)<br />
Dick & Connie Murley<br />
James & Lois VanVeghel<br />
Gordon Van Harn<br />
Roger & Susan Bratt<br />
Dale Vanderstelt<br />
Dale & Pamela Vanderstelt<br />
Timothy S. Vanderveen<br />
Ted & Joan Vanderveen<br />
Barbara VanHeulen<br />
Dave & Sally Baker<br />
Shirley Baumgardner<br />
Raymond & Priscilla Becker<br />
Mark & Marcia Borton<br />
Jack & Donna Boukma<br />
Carol Brooks<br />
Gracespring Bible Church<br />
Scott & Peggy Powlus<br />
Karl & Linda Prescher<br />
Susan Reinoehl<br />
Richard & Lori Teft<br />
Frank Vereecken<br />
David & Judy Aniszko<br />
Maribeth Constantine<br />
Frank & Jennifer Edwards<br />
James & Frances Norton<br />
Sally Norton<br />
Arthur & Karen Olson<br />
Sharon Wieland<br />
Albert Walcher<br />
Raymond & Gretchen Meyer<br />
Claudia Azkoul Walters<br />
James & Joy DeBoer<br />
Jennifer Webb<br />
David & Sallie Brinks<br />
Eric Westra<br />
Dianna DeVries<br />
Jack & Sandra Dik<br />
Thomas & Mary Beth Henry<br />
Ben & Robin Ipema<br />
Thomas & Donna Webb<br />
Randy Winchester<br />
Chuck & Lois Winchester<br />
Jerry Wright<br />
John & Andrea Cain<br />
Fishbeck, Thompson, Carr<br />
& Huber, Inc.<br />
Thomas & Julie Wright<br />
Jacob Zagaroli<br />
George & Linda Sharpe<br />
Gabe Amodeo<br />
Catherine Amodeo<br />
Richard Lutz<br />
Margaret Fondren<br />
David & Carol Van Andel<br />
Scott & Maggie Lancaster<br />
Richard & Terri MacKeigan<br />
Evan Beukema<br />
Emma Beukema<br />
Scott Bravata<br />
Universal Forest Products<br />
Inc.<br />
Steven Kruith<strong>of</strong>f<br />
Edward & Karen Bezilla<br />
Victoria Ludema<br />
Crowe LLP<br />
Thomas Newh<strong>of</strong><br />
James & Pamela Hegarty<br />
Ken & Jill Peirce<br />
Christopher & Renee Peirce<br />
George Sharpe<br />
Thomas & Jeannine Rizzo<br />
Greg & Meg Willit<br />
Duke Suwyn<br />
Kimberly Van Stee<br />
Alvin & Joyce Docter<br />
James Veldheer<br />
Greg & Karin McAleenan<br />
These lists represent gifts made between July 1, 2019, and December 31, 2019. The accuracy <strong>of</strong><br />
these lists is very important to us. Please contact 616.234.5552 if an error has been made.<br />
Honoring loved ones with a memorial gift to VAI<br />
Our mother, Gisela Kah, was a vibrant, vital woman who passed away this<br />
summer after a decade-long struggle with dementia. We chose to honor<br />
her by creating a memorial fund at Van Andel Institute. These tributes<br />
fund the important research at VAI in a deeply personal, meaningful<br />
way. We take comfort knowing that a gift in our mother’s name moves<br />
scientists and society ever closer to finding the next breakthroughs in<br />
treating the diseases that take our loved ones too soon.<br />
— Birgit Klohs<br />
— Greg Northrup<br />
— Astrid Müller<br />
— Julia Müller<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 31