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2007 Annual Report

A Groundbreaking Year

www.vai.org


ground • break • ing (ground’bra’king)

> the act or ceremony of breaking ground for a new construction project > markedly

innovative > originating or pioneering a new endeavor, field of inquiry, or the like

> being or producing something like nothing done or experienced or created before

02 A Letter from David Van Andel, Chairman & CEO

04 VAI Breaks Ground on Phase II

Van Andel Research Institute

06 A Letter from George Vande Woude, VARI Director

08 VARI 2007 Lab Highlights

12 Dr. Eric Xu Receives Third R01 Grant

14 Haab Invention Speeds Research and Saves Resources

16 Behind the Scenes

18 Training Programs

20 Grants Awarded to VARI Researchers - 2007

22 Daniel Nathans Memorial Award

23 Han-Mo Koo Seminar Series

24 Collaborations

26 Labs & Investigators and Core Services

Van Andel Education Institute

28 A Letter from Gordon Van Harn, VAEI Director

30 VAI Graduate School Convocation Commemorates Inaugural School Year

32 Highlighting and Supporting Undergraduate Research

33 Internal Medicine Research Residency Program

34 New Programs at Science Academy

Philanthropy & Development

38 A Letter from Joe Gavan, Vice President, Communications & Development

40 Hope on the Hill Donor Recognition

46 VAI Board & Council Members

48 Celebration of Hope

Van Andel Institute


VAI Phase II


VAI Phase

I

www.vai.org

1


A Letter from David Van Andel

Van Andel Institute Chairman & CEO

The year 2007 was literally a groundbreaking one at

Van Andel Institute (VAI). On April 12, despite the

incursions of an unusual spring snowstorm, we broke

ground on Phase II, a $170 million, 240,000 square-foot, eightstory

building expansion that will significantly increase the

Institute’s capacity to impact human health through basic and

translational research.

The constant activity of cranes and the significant community

investment in the life sciences on Grand Rapids’ Medical Mile

have not gone unnoticed by the national media. In July, the New

York Times published a front-page story in its business section

entitled “Grand Rapids Lays Foundations for a Health Mecca,”

which highlighted the region’s philanthropic efforts and detailed

the private investment that has spurred the development of the

life sciences in West Michigan. We are proud to be recognized

for our crucial role as the anchor of the life sciences industry in

West Michigan.

Both Van Andel Institute and West Michigan are attracting

national and international attention for their expanded role in the

Our Mission: Through biomedical research and

science education, Van Andel Institute is committed to improving

the health and enhancing the lives of generations to come.

Van Andel Institute


life sciences, and this is also evidenced by our growing number of

collaborative efforts with business, academia, clinical partners and

other researchers throughout the world.

In January, we signed an agreement with the National Cancer

Centre of Singapore forming the NCCS-VARI Translational Research

Program in Singapore. The three-year, $1.2 million program is funded

by the government of Singapore, and operates under the direction

of VARI Distinguished Investigator Bin Tean Teh, M.D., Ph.D. The

program focuses on the biology

behind varying drug responses in

Asian versus non-Asian patients with

specific types of cancers.

In March, we announced the creation

of the Center for Molecular Medicine

(CMM) in partnership with Spectrum

Health. The $6 million joint venture

offers molecular technologies for

investigation of complex diseases like

cancer and heart disease at the DNA,

RNA and protein levels. The CMM

combines Spectrum Health’s clinical,

laboratory and research resources,

and VAI’s research expertise with

the latest in molecular biological

technology.

Keeping ever in mind our dual

mission as both a research and

education institute, 2007 was also a watershed year for Van Andel

Education Institute, which saw the culmination of several years’ work

in some significant milestones and achievements, most notably as

the Van Andel Institute Graduate School welcomed its first three

Ph.D. candidates in cell and molecular biology in a convocation held

on August 20, 2007.

The NCCS-VARI program ribbon cutting in Singapore (l to r): David

Van Andel, George Vande Woude, Bin Tean Teh, and Khee Chee Soo

Underlying all of our efforts on both the research and education

side is the quest to fulfill our mission to improve the health and

enhance the lives of generations to come. Perhaps no other

achievement of the past year fulfills the definition of that mission

quite as well as the success of the Institute’s Compassionate Care

Protocol. A groundbreaking study in personalized molecular

medicine undertaken with several clinical partners, this protocol

utilizes a highly advanced database and set of analytical tools

developed in Van Andel Research Institute’s labs to profile a

patient’s tumor and integrate that

information with the individual’s

genetic profile to develop the

therapy most likely to be effective.

The study continues in 2008 with

the hope of enrolling up to 200

local cancer patients. We are

excited by the possibilities of the

coming year.

We are a relatively young facility,

but we’ve made remarkable

progress in the eight short years

since we opened our doors.

2007 was a year of significant

achievement and we look ahead

with the expectation that our

growing number of partnerships,

international recognition, an

expanded facility and the hard work

and passion of our researchers,

educators and staff will allow us to continue to make those lifechanging

discoveries.

David Van Andel

Chairman and CEO, Van Andel Institute

VAI Chairman

and CEO

www.vai.org

03


Van Andel Institute


VAI Breaks Ground on Phase II—

Project Scheduled for Completion Late 2009

Van Andel Institute (VAI) broke ground April 12, 2007, on

its $170 million, 241,000 square-foot, eight-story Phase

II building expansion. When operating at capacity, the

expansion will augment the existing 162,000 square-foot facility

to support a $125 million annual research

operation employing 800 researchers and

administrative staff, providing approximately

500 additional jobs. The project is scheduled

for completion in late 2009.

“Phase II is a continuation of our vision to have

an impact locally on education, regionally

on the economy and internationally on life

sciences,” said Van Andel Institute Chairman

& CEO David Van Andel, who first announced

the expansion in 2005, in celebration of the

Institute’s fifth anniversary.

Following an outdoor groundbreaking

ceremony, Van Andel unveiled the interior

design details of Phase II during an indoor

presentation. The interior design will

display elements that reflect the diversity of the Institute’s staff,

which represents 17 different nations. The design also includes

laboratories with a skylight roof over the laboratory space, which

offers the highest quality environment for scientific research.

In support of the expansion, local Michigan legislators presented

David Van Andel with a resolution of tribute from the Michigan

Legislature. Congressman Vernon J. Ehlers, R-Grand Rapids, spoke

on the impact that VAI has had on the developing life science

industry in Michigan.

“Grand Rapids is rapidly becoming a center for

medical research.” —Congressman Vernon J.

Ehlers, R-Grand Rapids

“Grand Rapids is rapidly becoming a center for medical research, in large

part because of the research efforts at the Van Andel Institute,” Ehlers

said. “Thanks to the Phase II expansion, both our area and our nation will

continue to benefit from groundbreaking discoveries at the Van Andel

Institute, and our area will also experience

economic benefits.”

Designed by architect Rafael Viñoly, Phase II

completes the promise of the physical facility

planned in 1996. The expansion provides space

for administrative offices and will nearly triple

the Institute’s laboratory space, allowing VAI

to broaden its research focus to include other

neurological disorders and chronic illnesses,

specifically through a new lab dedicated to

Parkinson disease research. The expansion

significantly increases the Institute’s capacity

to impact human health through basic and

translational cancer research, and provides an

expanded avenue for commercialization efforts

that complement that research.

The new facility, which will be LEED certified in support of the Institute’s

commitment to the environment, will also house the new Van Andel

Institute Graduate School, which matriculated its first students in August

2007. Space will also be utilized by students of the new regional medical

school, Michigan State University’s College of Human Medicine, which

is currently under construction on an adjacent location.

Opposite page (clockwise from top): David Van Andel drives bulldozer at

groundbreaking; panels representing Phase II interior design; rendering of

lobby facing west; poster at groundbreaking

VAI Phase

II Groundbreaking

www.vai.org

05


A Letter from George Vande Woude, Ph.D.

Van Andel Research Institute Director

Van Andel Institute’s Phase II building expansion is underway and exciting

for many reasons, but most importantly, the expansion will provide more

research labs to continue to expand our research footprint in Grand Rapids,

Michigan, the United States and the world. In this report, you’ll read about the research

already taking place today at the Van Andel Research Institute (VARI) labs and about

some of the accomplishments in 2007. Every day, we increase our understanding of

the complex activity and interaction of molecules and metabolites at work in the cells

that make up our bodies, what goes wrong in the case of disease, and how we can

use our knowledge to help patients.

Our research would not be possible without funding, and the success we have had

in the tight competition for grant funding is an important measure of the quality of

our research. In 2007, our researchers received several prestigious R01 grants from

the National Institutes of Health (NIH); Dr. Steve Treizenberg received a three-year

R01 award, Dr. Bart Williams received a five-year R01 award, and Dr. Eric Xu received

a four-year R01. It is important to note that Dr. Xu now has three active R01 grants.

Dr. Kate Eisenmann, Dr. Carrie Graveel, and Dr. Jim Resau received grants from the

Department of Defense (DOD) Breast Cancer Research Program; out of more than

1200 proposals reviewed, only 87 projects were recommended for funding. Dr.

Eisenmann, Laura Lamb, and Dr. Cindy Miranti also received grants from the DOD

Prostate and Ovarian Cancer Program.

Our many collaborative scientific projects now span the globe and are another

measure of our success as we establish tight links with scientists and research

Van Andel Research Institute

conducts basic and translational research into the genetic and molecular origins of cancer,

Parkinson disease, and other threats to human health, working to translate discoveries into

therapies that will one day conquer illness and enhance lives.

Van Andel Research Institute


programs around the world. We are pleased to announce the formation

of VARI International, headed by Dr. Bin Tean Teh. VARI International was

formed to organize and formalize the Institute’s international opportunities.

Currently, two laboratories with foreign host institutes are in operation. New

in 2007 was the formation of the National Cancer

Centre of Singapore (NCCS)–VARI Translational

Research Laboratory (headed by Dr. Teh). The

NCCS–VARI laboratory is focusing on translational

research on cancers that are prevalent in Asian

countries. The Nanjing Medical University (NMU)–

VARI Antibody Technology Laboratory (headed

by Dr. Brian Cao), established in 2005, continues

its work in the development of a variety of murine

and human monoclonal antibodies and antibody

fragments for potential clinical diagnostic and

therapeutic applications.

Cancer Immunodiagnostics. Dr. Haab was promoted to Senior Scientific

Investigator in August, and elected to a three-year term on the Board of

Directors of the U.S. Human Proteome Organization.

Finally, in the fall we presented the Daniel

Nathans Memorial Award to Harald zur Hausen

and Douglas R. Lowy. Dr. zur Hausen’s lab

identified infection by papillomavirus as the

main cause of cervical cancer, and Dr. Lowy’s

studies were instrumental in developing a

new way to prepare vaccines that prevent

infection by the virus. The importance of this

work in terms of improving human health

worldwide is obvious, and we are pleased

to have these distinguished researchers join

the list of Nathans Award recipients.

The Program of Translational Medicine under the

direction of Dr. Craig Webb has established the

essential infrastructure and partnerships that allow

VARI to collaborate with other institutions that will engage in exploiting

our cutting edge biomarker-driven clinical research. In 2007, this led to

the development of a specific, personalized medicine protocol, in which

genomic technologies are being used in conjunction with the powerful

biomarker software package developed by Dr. Webb and colleagues to

identify drug combinations to target the cancer proteins in tumors from

late stage cancer patients.

Congratulations go out to Dr. Brian Haab, who heads the Laboratory of

Research at VARI has implications for many different diseases, including:

Clearly, we have much to be proud of

and have cemented Van Andel Institute’s

reputation in the international research

community since we opened our doors in 2000. When we open the

doors to Phase II at the end of 2009, we anticipate having an even

greater impact.

George Vande Woude, Ph.D.

Van Andel Research Institute Director

VARI Director

www.vai.org

07


VARI 2007 Lab Highlights

VARI researchers had numerous findings published

in scientific journals in 2007; an overview of some

of the highlights is presented on the following

pages. As you can see, we continue to gain insight into the

inner workings of cells and what happens in disease, which

has an impact on diagnosis, treatment, and ultimately the

lives of patients.

* Primary labs and journals are listed in parentheses.

MET: Colon Cancer, Diagnosis, Drug Potential

>> The amount of MET protein in normal tissue, benign growths, and

tumors from the colon is similar, but different in varying tumor grades.

This suggests that other factors triggered by MET in the cell may have

a larger role in colon cancer development than MET itself. (Resau Lab

- International Journal of Oncology)

>> A peptide called Met-pep1 specifically interacts with Met proteins;

this peptide could be used to diagnose tumors with high Met levels

essentially by “tagging” Met in cells. (Cao Lab - Clinical Cancer

Research)

>> Mutated NK1 protein binds to cell receptors that Met protein

normally attaches to, essentially blocking Met without producing

its own effect in the cell. This finding could be important to the

development of anti-Met cancer drugs. (Xu Lab - Proceedings of the

National Academy of Sciences U.S.A.)

- - VARI Director Dr. George Vande Woude discovered and

characterized the MET gene, which results in the MET protein

that is found in higher than normal levels in many types of

cancer. MET has become a leading anti-cancer drug target.

>>

The Drf1 gene may play a role in myeloproliferative

disease (MPD) and myelodysplastic syndrome (MDS).

(Alberts Lab - Cancer Research and the Journal of Biological

Chemistry)

“Ultimately, our goal is to establish and use

genetic models of MDS and MPD to test,

evaluate, and improve upon current therapies for

the disease.”

—Art Alberts, Ph.D., Senior Scientific Investigator

Van Andel Research Institute


Important Genes and Proteins in Cancer:

Beta-Catenin, Myc, MIG-6

>> Prostate cells lacking the gene Apc multiply to form tumors

and contain high levels of beta-catenin protein, suggesting that

beta-catenin may play a role in prostate cancer development.

(Williams Lab - Cancer Research)

>> Myc protein is activated through a series of signals in the cell

and associated with the aggressiveness of papillary type 2 renal

cell carcinoma (RCC); blocking this signaling pathway at some

point is a potential avenue for therapy. (Furge and Teh Labs -

Cancer Research)

>>

A new method to identify alterations of carbohydrates

on certain proteins in disease may be used as a means

to detect or diagnose pancreatic cancer. (Haab Lab -

Nature Methods)

“The application of this method could lead to the

discovery and characterization of carbohydrate

structures that are instrumental in the pathology of

cancer and other diseases. This is a first and important

step in better diagnosis and treatment.”

—Brian Haab, Ph.D., Senior Scientific Investigator

>> Mutations in a potential tumor-suppressor gene, MIG-6, may be

associated with lung cancer. (Vande Woude Labs - Oncogene)

- - A tumor suppressor gene naturally helps to inhibit cancer

in some way.

Anthrax Insights and Use as Cancer Treatment

>> The LRP6 protein, previously believed to mediate anthrax

toxin’s entry into cells and thus its lethal effect, is not needed in

this process. (Duesbery Lab - PLoS Pathogens)

>> Treating Kaposi’s sarcoma, which is characterized by

abnormally dense blood vessels, with anthrax lethal toxin results

in reduced tumor growth most likely related to reduced blood

vessel density. This suggests that lethal toxin or similar molecules

could be used to treat Kaposi’s sarcoma. (Duesbery Lab - Clinical

Cancer Research)

- - Anthrax lethal toxin is a combination of two components

of the toxin released by the bacteria that cause anthrax. On

their own, each of these proteins that make up anthrax toxin

is harmless, but when all three are combined, they can be

deadly.

VARI Lab

Highlights 2007

www.vai.org

09


Chromosome Changes =

Changes in Tumor Type

>> Changes in the chromosomal content (e.g., number of

copies of each chromosome) of tumor cells occur when the

cell switches from a type that simply multiplies to one that

aggressively spreads. (Vande Woude Lab - Proceedings of the

National Academy of Sciences U.S.A.)

Insights into Cell Movement

>> The “skeletons” of cells change to facilitate several different

processes. The dynamics of these structures, controlled by the

protein mDia2, contribute to the movement of vesicles (storage and

transportation vehicles) within the cell. (Alberts Lab - Experimental

Cell Research)

>>

While prostate cancer cells need the enzyme PI-3K to

survive, normal prostate cells do not. (Miranti Lab -

Molecular Biology of the Cell)

“Our study confirms the therapeutic potential;

PI-3K is important because we now know that

therapeutics that target this enzyme could kill

tumor cells without having a negative effect on

normal cells.”

—Cindy Miranti, Ph.D., Scientific Investigator

>> Naturally occurring cellular protein DIP can trigger

“blebbing” – cell bubbling that has recently been linked to

the development of secondary tumors away from the primary

cancer site. (Alberts Lab - Current Biology)

“We now have a mechanism that we can target with

drugs aimed at interfering with cancer metastasis;

currently, no anti-cancer therapies block this critical

step in the malignancy process.”

—Art Alberts, Ph.D., Senior Scientific Investigator

Diagnostic Discoveries

>> A potential biomarker for prostate cancer could help avoid

unnecessary biopsies: thrombospondin-1. Higher levels of this

protein are found in patients with benign prostatic disease; the

opposite is true for patients with prostate cancer. (Haab Lab - The

Prostate)

Van Andel Research Institute


Two different categories of blood vessels in clear cell renal cell

carcinoma (CCRCC) tumors correlate with contrasting prognoses;

more of one vessel type is associated with higher tumor grades

and shorter patient survival, while more of the other vessel type

correlates with lower tumor grades and longer survival. This

information could be used to help diagnose and even determine

optimal treatment for patients based on what type of blood vessels

their tumors have. (Teh Lab - Clinical Cancer Research)

- - Tumors need access to blood vessels for nutrients and

other essentials to survive and grow.

>> A new method to profile cancer biomarkers for intestinal

tumors can help distinguish normal blood from that of genetic

models predisposed to intestinal cancer based on the levels of

as few as three markers, even when the predisposed models

have no tumors yet. (Haab Lab - Molecular Oncology)

- - A biomarker is something in the body that can be associated

with disease to help predict, diagnose, or determine optimal

treatment.

>> A new strategy to screen for, identify, and validate proteins from

tumors that trigger immune responses (tumor antigens) identified

the protein human Kallikrein 11 as one such protein in prostate

cancer and profiled its immune response. (Haab Lab - Proteomics

– Clinical Applications)

>>

“Switching off” the tumor suppressor gene Pten could

increase bone density in osteoporosis patients and people

with bone fractures, probably by allowing osteoblast cells

to live longer and make more bone cells. (Williams Lab -

Proceedings of the National Academy of Sciences U.S.A.)

VARI Lab

Potential for Treatment

>> The growth of tumor cells having high levels of epidermal

growth factor receptor (EGFR) is slowed when treated with an

anti-EGFR antibody that researchers developed and attached to

the chemotherapeutic drug Taxol. This combination could have

potential for clinical treatment of tumors having high levels of

EGFR. (Cao Lab - Cancer Biology & Therapy)

“We were discussing what could be involved

in helping bone cells survive longer with our

collaborations at the University of Alabama and our

work suggested that Pten might be important. Now

the trick is to turn off Pten only in bone-making

osteoblasts without affecting other cells.”

Highlights 2007

—Bart WIlliams, Ph.D., Senior Scientific Investigator

www.vai.org

11


Van Andel Research Institute


Dr. Eric Xu Receives Third R01 Grant

NIH Supports Cutting-Edge Structural Biology at VAI

Eric Xu, Ph.D., has ambitious plans for himself, Van Andel

Institute and for the life sciences industry in West Michigan.

Xu heads VARI’s Laboratory of Structural Sciences, which studies the

structures and functions of protein complexes that play major roles

in signaling pathways in order to develop therapeutic agents for the

treatment of diabetes and cancer.

Part of that work includes generating crystal

structures for analysis at one of the most

advanced x-ray facilities in the world. As

node director for the Michigan Life Sciences

Corridor Core Technology Alliance (CTA) and

the Michigan Center for Structural Biology

(MCSB), one of the CTA’s ten core facilities, Xu

makes frequent use of the Advanced Photon

Source, a national synchrotron x-ray research

facility at Argonne National Laboratory near

Chicago that provides one of the brightest

x-ray beams in the world.

Xu and his team produce crystals for medically

important protein targets that are subjected to intense x-ray radiation

and subsequent data analysis to provide the three-dimensional

information needed for structure-based design of new drugs.

Xu is striving to establish his research group as one of the most

cutting-edge research labs in structural biology in the world. The

grant makers at the National Institutes of Health (NIH) support Xu’s

endeavor. Since establishing the Laboratory of Structural Sciences

at Van Andel Institute in 2002, Xu has received three prestigious

R01 grants for three different research projects, an impressive

accomplishment considering that the NIH confers an award on less

Crystals generated by Xu Lab

than 10% of all unsolicited R01 grant applications.

Xu believes that Van Andel Institute and West Michigan are the right

places for such a lab.

“When I saw the commitment to the Institute from the Van Andel

family, I saw a once in a lifetime opportunity

for cutting edge structural biology,” said Xu.

“There is tremendous support and commitment

to support fundamental research, the results of

which can be translated into new medicines for

the treatment of human diseases.”

After studying at Duke University and working

in North Carolina’s Research Triangle Park,

home to more than 200 research and discovery

companies, Xu knows what it takes for a region

to develop a national presence in the life

sciences industry.

“North Carolina 20 years ago was nothing like

the West Michigan of today,” said Xu. “The

Research Triangle Park was tobacco farms. We have a much greater

head start than North Carolina had.”

Xu believes that Grand Rapids’ manufacturing heritage, and industrial

knowledge and infrastructure give the region a leg up among U.S.

regions currently incubating their own life science corridors. He is

also a firm believer in the entrepreneurial spirit of the region.

“One success can make a huge difference,” said Xu. “And the

entrepreneurial spirit of Grand Rapids will help in the translation

process. I also hope to play a role in seeding that kind of effort.”

VARI Eric

Xu, Ph.D.

www.vai.org

13


Van Andel Research Institute


Haab Invention Speeds

Research and Saves Resources

VARI Senior Scientific

Investigator Brian Haab,

Ph.D., is the inventor of

the SlideImprinter, a device

that partitions laboratory slides

in a way that has the potential to

improve research efficiency and

productivity. The Gel Company,

which commercially developed the

device, released the new product in

May 2007.

Haab’s lab at Van Andel Institute,

the Laboratory of Cancer

Immunodiagnostics, has been

using the prototype for over three

years. “We didn’t originally intend

to sell it,” said Haab. “But when we

saw how well it worked, we realized

this product had commercial

potential.”

Scientific researchers partition slides

to test many samples at once. This

process helps to speed up research

and also saves resources.

Haab invented the new slide partitioning method and device

with assistance from David Kruithoff, an engineer now working

at Lifeport, Inc., in Seattle. “I was looking at the commercially

SlideImprinter (top) and imprinted slide (bottom)

available options, and nothing really

worked well,” Haab said. “I thought

a stamp that imprints a hydrophobic

border might be a good solution.”

Kruithoff provided design insight and

suggested using wax for the border

material.

The SlideImprinter, which is 6 x 6 x

10 inches in size, imprints thin wax lines

onto the surface of a slide. This process

creates partitions that segregate the

slide into several “wells.” Researchers

can choose from four standard stamps

or a custom design depending on how

many wells they want to create. The

device immerses the stamp in a wax

bath, inserts a slide into a cartridge

over the bath, and then lifts the stamp

to meet the slide, imprinting wax

lines. The wax lines are thin enough

for the slide to be used in a microarray

scanner and are inert to most chemical

processes so they will not dissolve

easily or interfere with experiments.

Haab, who has shared information about the SlideImprinter with

colleagues at several scientific meetings and seminars, said he has

found strong interest in the device within the research community.

VARI Brian

Haab, Ph.D.

www.vai.org

15


Behind the Scenes

Positions within Van Andel Research Institute run the gamut from research associates, scientists, and technicians to lab managers,

investigators, and directors to specialized roles. These people work diligently to keep labs running smoothly and research moving

forward. Here we highlight a few of the many who work “behind the scenes.”

Angelique Berens

Assistant Research Technician

Works on Met research and helps to

manage lab

J.C. Goolsby

Histotechnologist

Works on receiving,

processing, embedding

and sectioning tissue

Angelique Berens’ goal is to become an oncologist,

maintaining an important role in cancer research and the

development of new therapeutic options throughout her

career. Berens is excited about a VAI collaboration with Tel Aviv

University that has resulted in “genetic signatures” of Met

levels in breast cancer that has shown strong correlation with

prognosis of human breast cancer patients. “These signatures

can be used for personalizing anti-Met therapy,” she said. “As

a future physician, it is very rewarding to see the research I

am involved in have clinical applications in the near future.”

Berens is leaving VAI in 2008 to attend medical school for four

years at Wayne State University’s School of Medicine.

J.C. Goolsby was born and raised as a sharecropper in the tobacco

fields of North Carolina. Starting at age seventeen, he served

in the Navy for almost ten years. “Being the first of my family’s

generation to obtain a college degree thanks to Dr. Jim Resau

and VAI has raised my awareness of the importance of a college

education,” said Goolsby, who started at VAI as the head of

Housekeeping. Goolsby plans to complete his degree in Biology

at Grand Valley State University and go to school to become a

histologist.

Van Andel Research Institute


Roberta Jones

Director of Research Administration

Coordinates all support functions for

the research laboratories

Sok Kean Khoo

Associate Director of

Laboratory of Germline

Modification and

Cytogenetics

Roberta, or “Bobbie,” Jones worked at Walter Reed Army

Medical Center from 1967-1970 during the Vietnam War

and was struck by the many examples she witnessed of the

resilience of the human body and spirit and the courage of

patients in the face of painful treatments and rehabilitation.

Jones has worked with VARI Director George Vande Woude,

Ph.D., since 1983 when they were both working at the

National Cancer Institute’s Frederick Cancer Research and

Development Center in Maryland. She remembers when she

first came to VAI: “I arrived in Grand Rapids when our building

was still a hard-hat construction site. Watching the building rise

and then become populated with highly motivated scientists

who are truly making a difference has been very exciting. I feel

very fortunate to have been a part of it.”

Responsibilities include

research, customer

service, and training

Sok Kean Khoo, a native of Malaysia who received her

Ph.D. in Tokyo, was excited when she heard of a job

opportunity at VAI. “I felt that America was doing some

of the most advanced bioscience research,” she said.

Khoo draws satisfaction from the fact that she is directly

supporting translational research at VAI through her

work. She encourages young people to pursue careers in

science by describing her career to students in the local

Junior Achievement program.

VARI Behind

the Scenes

www.vai.org

17


Training Programs

Through VARI training programs, students learn what a career in science involves by working in the laboratory, and postdoctoral

fellows gain critical work experience before moving on to laboratories of their own. All further VARI projects through their work

conducted under the mentorship of VARI scientific investigators.

Postdoctoral Fellowships

Internships

Scientists beginning their research

careers after graduate school advance

their knowledge and research

experience as postdoctoral fellows,

working on VARI projects under the

mentorship of a scientific investigator.

They also attend seminars, interact with

graduate students studying at VARI,

participate in outreach programs, and

attend social events through the Office

of Postdoctoral Fellows.

College and university students work in

VARI labs and help to define their career

paths through internships, including

those that are a part of the Frederik and

Lena Meijer Student Internship Program.

Through this program, students are

mentored by professionals in their chosen

research field during an intense 10-week

experience.

“I’ve never regretted choosing VARI over a fellowship

at Harvard—the smaller size, top-of-the-line

equipment and facilities, principal investigators that

are accessible, energetic and passionate about their

research, and the affordable, family-friendly location

have all made for a great experience.”

—Postdoctoral Fellow Jenn White, Ph.D.

“You learn current research methods and

technologies, but also how to design experiments

and communicate results. There is great training

on presentation skills and communicating and

collaborating with other researchers.”

—University of Michigan student Theresa Gipson

Van Andel Research Institute


VAI-MSU Graduate

Program

Bridges to the

Baccalaureate

The VAI-MSU Graduate School

Program allows students in one

of five Michigan State University

graduate programs to conduct

one of their laboratory “rotations”

at VARI and then complete their

thesis project at the Institute if

they choose. Program participants

conduct research, have access

to the latest technologies in the

VARI core facilities, participate

in VARI journal clubs, and attend

seminars, lab meetings, retreats

and conferences.

“The open lab space and interaction between

scientists has definitely been the best part. The

whole glass roof thing also adds to my productivity;

I love the sun. Some of us spend more time at the

Institute than at home, and the great people, great

facility, and great research makes us more willing

to do that.”

—Michigan State University student Sebla Kutluay

The Bridges program provides

support to minorities who are

under-represented in medical

research and who attend Grand

Rapids Community College.

Students are eligible to present

their research findings at the

NIH Minority Symposium held

annually in the fall. Participants

are helped to graduate to the

baccalaureate level and are

simultaneously dual-enrolled at Grand Valley State University.

“The opportunity to work with many talented scientists

and the research experience have proven to be the most

rewarding experiences for me as a Bridges student.”

—Grand Rapids Community College student Sergio Rodriguez

GRAPCEP

The Grand Rapids Area Pre-College Engineering Program (GRAPCEP) is

administered by Davenport University and jointly sponsored and funded by

Schering Plough and VARI. The program provides high school students who

plan to major in science or genetic engineering in college the opportunity to

work in a research laboratory. Students learn research methods and workplace

success skills such as teamwork and leadership.

VARI Training

Programs

www.vai.org

19


Grants Awarded to VARI Researchers - 2007

One of the indicators of the quality and impact of the research conducted at Van Andel Institute is the success of our researchers in

competing for grant funding. In 2007, researchers were awarded highly competitive grants and renewals for grants from organizations such

as the National Institutes of Health (NIH), the Department of Defense, the National Foundation of Cancer Research, the American Cancer

Society, and the American Heart Association.

Sponsor

> MEDC/Department of Treasury

> MEDC/21st Century Jobs Fund

> NIH/National Heart, Lung & Blood Institute

>

>

NIH/National Institute of Arthritis &

Musculoskeletal & Skin Diseases - R01

NIH/National Institute of Diabetes &

Digestive & Kidney Diseases - R01

NIH/National Institute of Allergy &

Infectious Diseases

NIH/National Institute of Diabetes &

Digestive & Kidney Diseases - R01

NIH/National Cancer Institute - R01

+ Minority Trainee Supplement

Gerber Foundation

American Cancer Society

American Cancer Society

American Cancer Society

> Department of Defense

> Department of Defense

> Department of Defense

Project Title

Creation of Good Manufacturing Practicies (GMP) Facility

Development of an Innovative Clinical Research Alliance

Structural and Functional Studies of Nuclear Receptor PPSRgamma

Analyzing the Role of Wnt Signaling in Bone Development

Stucture and Functions of Steroid Hormone Receptors

Chromatin and Coactivators in HSV-1 Gene Regulation

Structural Genomics of Orphan Nuclear Receptors

MEK Signaling in Sarcoma Growth and Vascularization

Gene Expression Profiling in Newborns with Congenital

Chromosomal Abnormalities

Diaphanous-Related Formins in Myelodysplasia

Integrin and RTK Signaling and Crosstalk in Prostate Epithelial Cells

Identifying Small Molecule Inhibitors of Cdc7 Kinase

A Role for Formin-Mediated Cytoskeletal Regulation in the

Mesenchymal-Amoeboid-Transition in Breast Cancer Development

Met Signaling Promotes Mammary Stem Cell Proliferation

Intravital Imaging of Developing Breast Cancer Lesion of Defined

Genomic Profile in a Mouse

FY 2007 Total

$1,000,000

$484,800

$455,000

$400,471

$399,681

$364,000

$318,317

$306,459

$195,415

$180,000

$180,000

$180,000

$136,500

$136,500

$136,500

Van Andel Research Institute


indicates new grants awarded in fiscal year 2007

Sponsor

Project Title

FY 2007 Total

>

Breast Cancer Research Foundation

Novel Approach for Breast Molecular Imaging and Therapy using

Met Tyrosine Kinase as a Target

$125,000

NIH/National Cancer Institute via

University of Pittsburg - U01

Multiplexed Serum Biomarkers for Pancreatic Cancer

$90,065

MEDC/MTTC via University of Michigan

Proteomics Alliance for Cancer Research

$82,896

MEDC/MTTC via University of Michigan

Proteomics Alliance for Cancer Research

$68,790

>

Genentech, Inc.

Growth Curve of H1650, H1666, and SK-MES-1 in HGF/SF-SCID

Mice Xenograft Study

$59,502

>

National Foundation of Cancer Research

Guided Molecular Therapeutic Studies of Kidney Cancer

$50,000

NIH/National Institute of Child Health &

Human Development via Michigan State

University - T32

Training Program in Perinatal Epidemiology

$43,326

>

>

>

>

NIH/National Cancer Insitute via

University of Michigan - P50

Spectrum Health

VHL Family Alliance Fund for

Cancer Research

Knights Templar Eye Foundation

NIH/National Cancer Insitute/SAIC-

Frederick, Inc. via University of Michigan

American Heart Association

In-Vivo Imaging of Neoplasia

P13K-m TOR Pathway Bioinformatics and Therapy in

Colorectal Cancer

Multigenic Process in VHL-Related and Sporadic Clear Cell Renal

Cell Carcinoma (ccRCC): Characterization of a Novel VHL-Synergistic

ccRCC-Related Gene in Chromosone 5q

The Role of MAPK Signaling in Vascular Development in the Eye

Proteomic Technologies Easter Research Resources Consortium

Role of Transcriptional Coactivators in Herpes Simplex Virus

Gene Expression

$41,530

$40,000

$35,000

$30,000

$26,665

$26,000

VARI2007 Grants

>

McCarthy (J.P.) Fund/Community

Foundation of Southeast Michigan

Defective mDia1/DIAPH1 Expression in Myelodysplastic Syndromes

$25,000

>

Orthopaedic Research and Education

Foundation

Differential Growth and Metastasis of Human Osteosarcoma

Xenografts in a Human HGF/SF Transgenic Mouse Model with Multi-

Modality Imaging Assessment

$20,000

www.vai.org

21


VAI Bestows Daniel Nathans

Memorial Award on Leaders in HPV Research

On September 13, Van Andel Institute presented its

annual Daniel Nathans Memorial Award to two scientists

instrumental in investigating human papillomavirus

(HPV) and its links to cervical cancer. Harald zur Hausen, M.D.,

whose laboratory identified infection by HPV as the main cause

of cervical cancer, and Douglas R.

Lowy, M.D., whose studies helped

lead to highly successful vaccines

that prevent infection by these

viruses, received the award in a

ceremony at the Institute.

“The war on cancer began with

a promise to develop antiviral

vaccines that would prevent

malignant disease,” said Van Andel

Research Institute Director George

F. Vande Woude, Ph.D. “The

selection of this year’s awardees

is for contributions that allow this

promise to be fulfilled.”

The Daniel Nathans Memorial Award

is conferred by Van Andel Institute’s

Board of Scientific Advisors for

contributions to biomedical and cancer research. The recipient’s

contributions must be far-reaching and significantly benefit

public health. The award was established in 2000 to honor the

late Dr. Daniel Nathans, a 1978 recipient of the Nobel Prize and

a founding member of the Institute’s Board of Scientific Advisors,

who died in 1999.

(l to r) Harald zur Hausen, M.D., George Vande Woude,

Ph.D., and Doug Lowy, M.D.

Dr. zur Hausen is Professor Emeritus of the German Cancer Research

Center. He studied medicine at the Universities of Bonn, Hamburg

and Dusseldorf and received his M.D. in 1960. He is the discoverer

or co-discoverer of numerous novel virus types, proposed the role of

papillomavirus in the etiology of cervical cancer in the early 1970’s,

and proved their role a decade later.

Dr. Lowy is Chief, Laboratory of

Cellular Oncology, Deputy Director,

Division of Basic Sciences & Center

for Cancer Research at the National

Cancer Institute. He received his M.D.

from New York University School of

Medicine in 1968. Together with longtime

associate John Schiller, Ph.D., his

work with virus-like particles (VLP’s) has

led to the development of the HPV

VLP vaccine. Commercial versions

of the vaccine have been approved

by the FDA and should have a major

impact in cancer prevention.

Past recipients of the Daniel Nathans

Memorial Award include: Richard D.

Klausner, M.D., 2000; Francis S. Collins, M.D., Ph.D., 2001; Lawrence

H. Einhorn, M.D., 2002; Robert A. Weinberg, Ph.D., 2003; Brian

Druker, M.D., 2004; Tony Hunter, Ph.D., and Tony Pawson, Ph.D.,

2005.

Van Andel Research Institute


Han-Mo Koo

Seminar Series

Van Andel Institute hosts speakers from some of the most respected

academic, federal, and private research institutes in the nation

through its Han-Mo Koo Seminar Series, dedicated to the memory

of VAI Principal Investigator Han-Mo Koo (right), who passed away in 2004

following a six-month battle with cancer.

Speakers from 2007 (listed in order of speaking schedule):

> Moses Lee, Ph.D., Hope College

> Raj Kumar, Ph.D.,

University of Texas Medical Branch

> David Kimelman, Ph.D.,

University of Washington, Seattle

> Arthur L. Haas, Ph.D., Louisiana State

University Health Sciences Center

> S. Stoney Simons Jr., Ph.D.,

National Institute of Diabetes & Digestive &

Kidney Diseases, NIH

> John D. Shaughnessy, Jr., Ph.D.,

University of Arkansas for Medical Science

> Melanie H. Cobb, Ph.D., University of Texas

Southwestern Medical Center

> Christopher G. Wood, M.D., F.A.C.S.,

University of Texas M.D. Anderson Cancer Center

> Jules J. Berman, Ph.D., M.D., National Cancer

Institute (former program director)

> Shiv Grewal, Ph.D., National Cancer Institute

> Ermanno Gherardi, M.D., M.A., Ph.D., MRC Centre

> Caroline Alexander, Ph.D.,

McArdle Laboratory for Cancer Research,

University of Wisconsin, Madison

> David A. Cheresh, Moores University of

California, San Diego Cancer Center

> Bruce R. Ksander, Ph.D.,

Schepens Eye Research Institute; Department

of Ophthalmology, Harvard Medical School

> Peggy Farnham, Ph.D.,

University of California, Davis

> Daniel D. Von Hoff, M.D., F.A.C.P,

Translational Genomics Research Institute

> Arul Chinnaiyan, M.D., Ph.D.,

University of Michigan

> Eddy Arnold, Ph.D., Rutgers,

The State University of New Jersey

> Michael Glotzer, Ph.D., University of Chicago

> Andries Zijlstra, Ph.D., Vanderbilt University

>

Atul Butte, M.D., Ph.D.,

Stanford University School of Medicine

> Michael Ohh, Ph.D., University of Toronto

> Phil Hieter, Ph.D., University of British Columbia

> Dimiter S. Dimitrov, Ph.D., Sc.D.,

National Cancer Institute

> Robert L. Nussbaum, Ph.D., University of

California, San Francisco

> Timothy P. Cripe, M.D., Ph.D., Children’s

Hospital Medical Center, Cincinnati

> Gary D. Stoner, Ph.D., Ohio State University

> Stephen Bell, Ph.D., Howard Hughes Medical

Institute; Massachusetts Institute of Technology

> Diane M. Simeone, M.D., Multidisciplinary

Pancreatic Cancer Clinic; U of M Medical School;

U of M Comprehensive Cancer Center; U of M

Medical Center; U of M Department of Surgery;

U of M Medical School

> G. David Roodman, M.D., Ph.D., University of

Pittsburgh; Center for Bone Biology, University of

Pittsburgh Medical Center; University of Pittsburgh

Cancer Institute

VARIPrestigious Guests

www.vai.org

23


Argonne National Laboratory

Argonne, IL

University of Illinois

Champaign-Urbana, IL

University of Chicago

Chicago, IL

Northern Illinois University

DeKalb, IL

Evanston Northwestern Healthcare

Evanston, IL

Northwestern University

Evanston, IL

Immtech Pharmaceuticals

Vernon Hills, IL

University of Wisconsin - Madison

Madison, WI

University of Cincinnati

Cincinnati, OH

Ohio State University

College of Medicine & Public Health

Columbus, OH

Fred Hutchinson

Cancer Research Center

Seattle, WA

University of Washington

Seattle, WA

University of Utah

Salt Lake City, UT

Nevada Cancer Institute

Las Vegas, NV

University of California

San Fransisco & Los Angeles, CA

Orphagen Pharmaceuticals

San Diego, CA

TGEN

Phoenix, AZ

University of New Mexico

Albuquerque, NM

University of Toronto

Toronto, Ontario, Canada

VisualSonics, Inc.

Toronto, Ontario, Canada

Washington

University

St. Louis, MO

University of

Nebraska

Omaha, NE

Mary Crowley Cancer Center

Dallas, TX

University of Texas

Southwestern Medical Center

Dallas, TX

University of Texas

Medical Branch at Galveston

Galveston, TX

Baylor Breast Center

Houston, TX

Baylor College

of Medicine

Houston, TX

M.D. Anderson Cancer Center

Houston, TX

The Methodist Hospital

Houston, TX

University of Alabama

- Birmingham

Birmingham, AL

McGill Cancer Center

Montreal, Quebec, Canada

University of Montreal

Montreal, Quebec, Canada

Beth Israel Deaconess Medical Center

Boston, MA

Harvard University

Boston, MA

Massachusetts Institute of Technology

Cambridge, MA

Novartis Institutes for Biomedical Research

Cambridge, MA

Waters Corporation

Milford, MA

Rosewell Park Cancer Institute

Buffalo, NY

Albert Einstein Medical School

Bronx, NY

New York University

New York, NY

Schering-Plough Research Institute

Kenilworth, NJ

New Jersey Medical School

Newark, NJ

Muhlenberg College

Allentown, PA

Lankenau Research Institute

Philadelphia, PA

Assoc. of American Cancer Institutes

Pittsburgh, PA

University of Pittsburgh

Pittsburgh, PA

Johns Hopkins University

Baltimore, MD

National Institutes of Health

Bethesda, MD

-Nat’l Cancer Institute - Genetics Branch

-Nat’l Institute of

Neurological Disorders and Stroke

-Nat’l Institute of Dental and

Craniofacial Research

-Nat’l Institute of Neurological Disorders

and Stroke

Assoc. of Independent

Research Institutes

Westminster, MD

Duke University

Durham, NC

East Tennessee State

University

Johnson City, TN

Vanderbilt University

Nashville, TN

Federal University of Rio de Janeiro

Rio de Janeiro, Brazil

St. James’s Hospital

Dublin, Ireland

University of Birmingham

Birmingham, United Kingdom

Medical Research

Council Center

Cambridge England

University of Cambridge

Cambridge, England

University of Gothenburg

Gothenburg, Sweden

Faculté de Médecine Paris-Sud

Paris, France

Norwegian University

of Science and Technology

Trondheim, Norway

Karolinska Hospital

Stockholm, Sweden

University Hospital

Lund, Sweden

Dusseldorf University

Dusseldorf, Germany

Technische Universität

Munich, Germany

Aristotle University

of Thessaloniki

Thessaloniki, Greece

Leiden University

Medical University

Leiden, The Netherlands

University of Helsinki

Helsinki, Finland

Tel Aviv University

Tel Aviv, Israel

Van Andel Research Institute


Nanjing Medical University

Antibody Technology

Development Program

Nanjing, China

University of Malaya

Kuala Lumpur, Malaysia

Yansei University

Seoul, South Korea

Tianjin Cancer

Institute & Hospital

Tianjin, China

Guangzhou University

Guangdong Province, China

Sun Yat-sen University

Guangzhou, China

Singapore General Hospital

Singapore

National Cancer Centre

Translational Research Program

Singapore

National University of Singapore

Singapore

New in 2007 National Cancer Centre

Translational Research Program

VAI Distinguished Scientific Investigator Bin Teh, M.D.,

Ph.D., directs the Translational Research Program,

a collaboration with the National Cancer Center,

Singapore (NCCS), that focuses on the biology behind

varying drug responses in Asian versus non-Asian

cancer patients. The program provides a larger patient

base for rare cancers – 55 percent of all cancer cases in

Singapore are captured by the NCCS network.

New in 2007 Compassionate Care Protocol

Craig Webb, Ph.D., director of VAI’s Program of Translational

Medicine, spearheads the Compassionate Care Protocol, a

study by VAI and several clinical partners that aims to provide

personalized medicine to advanced-stage cancer patients. Using

a database developed by Webb’s lab, detailed molecular and

genetic data from patients’ tumors helps determine which unique

combination of drugs will have the greatest impact on treatment.

The study continues in 2008 with the hope of including up to 200

local cancer patients.

Iwate Medical University

Morioka, Japan

Kitasato University School of Medicine

Kanagawa, Japan

University of Tokushima

Tokushima, Japan

University of Queensland

Brisbane, Australia

Griffith University

Nathan, Queensland, Australia

University of Sydney

Sydney, Australia

Collaborations

One of Van Andel Institute’s founding principles is to

collaborate with local, national, and international

scientists and organizations. Collaborations quicken

the pace of progress, opening up new avenues of research and

generating new ideas. Many of our research collaborations from

2007 are represented on the map to the left; you can see that

Van Andel Institute is not only connected to our local community,

but to a world of partners.

Collaborations Close to Home

Ann Arbor, MI

> Department of Veterans Affairs

Healthcare System

> Lansing Reveal Technologies

> Pfizer (also St. Louis, MO and

Groton, CT locations)

> University of Michigan

Detroit, MI

> Barbara Ann Karmanos Institute

> Henry Ford Hospital

> Wayne State University

Grand Rapids, MI

> Academic Surgical Associates

> Advanced Radiology Services

> Cancer & Hematology Centers

of Western Michigan, P.C.

> Center for Molecular Medicine

> ClinXus

> Compassionate Care Protocol

> Core Technology Alliance

> Cornerstone University

> Digestive Disease Institute

> Grand Rapids Clinical Oncology

Program

> Grand Valley Medical Specialists

> Grand Valley State University

Good Manufacturing Practices

Facility

> Helen DeVos Children’s Hospital

Pediatric Center Fellowship Program

> Michigan Medical, P.C.

> Spectrum Health

> Saint Mary’s Health Care

> West Michigan Center for Family Health

> West Michigan Heart, P.C.

> XB TransMed Solutions

(XB-Biointegration Suite)

>

Holland, MI

Hope College

Kalamazoo, MI

> Jasper Clinical Research & Development, Inc.

> ProNAi Therapeutics

>

>

>

East Lansing, MI

Michigan State University

Lansing, MI

Michigan Cancer Consortium

Mt. Pleasant, MI

Central Michigan University

St. Joseph, MI

> GeneGo, Inc.

> Oncology Care Associates

VARI Collaborations

www.vai.org

25


Core Services

Core laboratories at Van Andel Institute

(VAI) provide our researchers and

external customers with several services

essential to the research process. Having

these services available on site helps to

streamline the research process. Our core

services include:

Analytical, Cellular, and Molecular

Microscopy (Imaging, Histology and

Diagnostic Pathology): pathology, tissue

resources, paraffin, frozen and plastic tissue

processing, Vibratome processing/sectioning, laser

capture micro-dissection, laser scanning confocal

imaging, in vivo intravital imaging, digital imaging,

spectral imaging and deconvolution

Antibody Production: monoclonal and polyclonal

antibody production, purification (Protein-G affinity

column, PBS), characterization (IgG, IP, Western, IFA),

immunization, serum screening, fusion, recloning,

expanding, freezing and growing hybridoma cell

lines, lyophilization, immunolabeling, affinity column

preparation, bi-specific mAbs

Computational Biology: custom data analysis

and consulting, assistance with computationally

intensive tasks, writing of niche programs that perform

data-specific tasks not commonly found in existing

commercial software, assistance in using sequence

analysis tools and gene expression microarray

analysis programs

Flow Cytometry: 12-Color BD FACSAria High-

Speed Cell Sorters, 2 4-Color BD FACSCalibur Cell

Sorter, 96/384 Well HTS Autosampler, NPE Cell

Analyzer, CBC with differential, blood chemistry

profile, data analysis, Shandon Cytospin 3

Germline Modification and Cytogenetics:

electroporation of ES Cells, Clone Selection, and DNA

Isolation, thawing and expansion of ES cell clones,

electroporation of Cre recombinase, microinjection of

blastocysts, tail biopsy, DNA isolation, preparation of mouse

embryonic fibroblasts, fluorescent in-situ hybridization

(FISH), spectral karyotyping (SKY), transgene localization,

routine karyotyping (G-banding), chromosomal breakage

studies, mouse embryonic stem (ES) cell trisomy 8 screening,

mouse embryo cryopreservation, marker-assisted selection

breeding using SNP array (Illumina BeadStation), genomic

background verification (inbred strains only)

Mass Spectrometry and Proteomics: label-free

LC-MS protein expression profiling, protein identification from

gels and solution, protein molecular weight determination,

protein characterization by peptide mapping

Microarray Technology: agilent oligonucleotide gene

expression microarrays (customizable), ArrayCGH, miRNA

expression microarrays, microarray data analysis, RNA

isolation and amplification, RNA integrity analysis, DNA

isolation and size/concentration analysis, spotted cDNA

microarray printing, custom protein microarray printing

Sequencing: plasmid, single-stranded templates,

cosmids/PACs/BACs, lambda phage DNA, ABI 3700-capillary

electrophoresis DNA sequencer, applied Biosystems BigDye

sequencing kit, Sephadex G-50 spin column plates for excess

dye removal

Vivarium: mouse transgenics, transgenics microinjection

services, tail biopsies, mouse repository services

Xenotransplantation: over- or underexpress gene(s) in

established cell lines to validate their role in the etiology of

tumors and their malignant progression, analysis and testing

of therapeutics

Basic Science

George Vande Woude, Ph.D.

VARI Director and Distinguished Scientific Investigator

Laboratory of Molecular Oncology

Focuses research on the protein Met, which has been found

to be overexpressed in most solid tumors.

Animal Imaging: Laboratory of Noninvasive

Imaging and Radiation Biology

Develops models and partnerships to address problems in

medical imaging and radiation exposure, advance imaging

and radiation technology, and improve systems and care.

Art Alberts, Ph.D.

Senior Scientific Investigator

Laboratory of Cell Structure and Signal

Integration

Studies structures that allow cells to change shape and

move, important to understanding how cancer spreads.

Brian Haab, Ph.D.

Senior Scientific Investigator

Laboratory of Cancer Immunodiagnostics

Investigates protein and carbohydrate abnormalities in

cancer patients’ blood and their potential clinical usefulness

and the role of protein secretions in cancer progression.

Nick Duesbery, Ph.D.

Deputy Director for Research Operations

and Senior Scientific Investigator

Laboratory of Cancer and Developmental Cell

Biology

Uses non-lethal components of anthrax to develop a new

way to fight cancers and learn more about tumor growth

and blood vessel formation.

Van Andel Research Institute


Labs & Investigators

Our laboratories and scientific investigators are dedicated to developing a new understanding of cancer that will help to prevent, treat, and

cure human disease.

Special Programs

Jeff MacKeigan, Ph.D.

Scientific Investigator

Laboratory of Systems

Biology

Uses RNA interference to study

the interaction of molecules

within the cell and connect them

to Parkinson disease and the

onset and spread of kidney and

colon cancer.

Craig Webb, Ph.D.

Scientific Investigator

Laboratory of Tumor

Metastasis and Angiogenesis

Studies how a tumor spreads to

distant parts of the body and is

involved in several partnerships

with the goal of predicting optimal

therapies for cancer patients.

Jim Resau, Ph.D.

Deputy Director of Special Programs;

Director, Division of Quantitative Sciences;

Distinguished Scientific Investigator

Laboratory of Analytical, Cellular,

& Molecular Microscopy

Provides imaging services and tissue

arrays that allow researchers to view

several samples of interest more quickly.

Kyle Furge, Ph.D.

Scientific Investigator

Laboratory of

Computational Biology

Uses mathematical and

computer science approaches

to help scientists analyze, store,

and distribute research data.

Cindy Miranti, Ph.D.

Scientific Investigator

Laboratory of Integrin

Signaling and

Tumorigenesis

Studies how a cell interacts with its

surroundings and receives signals

from other parts of the body

through proteins called integrins

in normal vs. cancer cells.

Bin Tean Teh, M.D., Ph.D.

Director of VARI International;

Director of NCCS-VARI Translational

Research Laboratory; Distinguished

Scientific Investigator

Laboratory of

Cancer Genetics

Works to identify and study the

genetic alterations found in

hereditary cancers versus those

found in sporadic cases, with a

special focus on kidney cancer.

Steve Triezenberg, Ph.D.

VAI Graduate School Dean

and Scientific Investigator

Laboratory of

Transcriptional Regulation

Uses herpes simplex virus to

explore the mechanisms that turn

on genetic “instructions” at the

right time, in the right cells, in

response to the right signals – and

what goes wrong in disease.

Michael Weinreich,

Ph.D.

Scientific Investigator

Laboratory of

Chromosome Replication

Works to understand the process

of chromosome replication within

cells to find a way to specifically

target and stop the division of

cancerous cells.

Bart Williams, Ph.D.

Senior Scientific Investigator

Laboratory of Cell Signaling

and Carcinogenesis

Studies the Wnt family of

proteins, their associated

molecules and their implications

in prostate cancer, bone

formation, and osteoporosis.

Eric Xu, Ph.D.

Distinguished Scientific Investigator

Laboratory of Structural

Sciences

Studies the structures and

functions of protein complexes;

the structural information can then

be used to develop therapeutic

agents for human diseases such

as cancer and diabetes.

Brian Cao, M.D.

Senior Scientific Investigator

Laboratory of Antibody

Technology

Produces, purifies, and characterizes

antibodies, which can be used to

mark or identify specific molecules

such as potential drug targets.

Greg Cavey, B.S.

Scientific Investigator

Laboratory of

Mass Spectrometry

and Proteomics

Separates, analyzes, and identifies

individual proteins in cells,

allowing researchers to find protein

differences between normal and

cancer cells.

Bryn Eagleson,

B.S., RLATG

Vivarium Director

Vivarium and Laboratory

of Transgenics

Develops, provides, and supports

high-quality mouse modeling

services for researchers.

Pam Swiatek,

Ph.D., MBA

Senior Scientific Investigator

Laboratory of Germline

Modification

Provides gene-targeting

services in order to develop

mouse models that help

researchers learn more about

genetic mutations involved in

disease.

VARI Labs

& Investigators

www.vai.org

27


A Letter from Gordon Van Harn, Ph.D.

Van Andel Education Institute Director

Van Andel Education Institute (VAEI) marked its tenth

anniversary of education programs with many significant

“firsts” during 2007.

The Van Andel Institute (VAI) Graduate School held its first opening

convocation on August 20, 2007, to inaugurate the school and

welcome its first class of three Ph.D. candidates in cell, molecular

and genetic biology. The convocation reflected years of planning

for the start of the school, and celebrated the three students who

were hailed as “pioneers.”

2007 also saw the first student admitted to the innovative Internal

Medicine Research Residency Program, a partnership between

VAI Graduate School and the Grand Rapids Medical Education

Research Center (GRMERC), which offers students a Ph.D. degree in

molecular and cell biology and state licensure and board eligibility

in internal medicine. The program is designed to provide clinical

and research training to produce physicians who are prepared for

careers as basic science and clinical research scholars.

The Graduate School co-hosted the first annual West Michigan

Van Andel Education Institute

nurtures the scientists of tomorrow through groundbreaking educational programs for

a wide range of students and professionals that build on curiosity and problem-solving

skills with real, hands-on experiences.

Van Andel Education Institute


Regional Undergraduate Science Research Conference on October

20, 2007. The one-day conference was attended by more than 200

students and faculty from eight regional colleges and universities

and featured 120 undergraduate student

presenters. It was a great demonstration

of the widespread interest in the emerging

biomedical research community in West

Michigan.

In September, VAEI convened educators,

and corporate and community leaders

from West Michigan to explore a model

of science education reform. The National

Science Resource Center presented

strategies that could result in improved

science instruction and student academic

achievement in science. Participation in

this forum reflected the need for more

persons prepared for science-related

positions, a driver for a healthy economy.

VAEI also introduced two new, innovative Science Academy programs:

Science on Saturday (SOS) and Classroom Science Investigations

(CSI). SOS welcomes students and a significant adult in their lives to

the Science Academy on a Saturday to help foster a love of science.

It introduces parents to important strategies for teaching

students in ways that both engage them and help them to

understand the nature of science. CSI was piloted in 2007 as

a unique professional development

initiative and a way of expanding

the VAEI model of science

instruction. A Kellogg Foundation

grant generously provides funds to

replicate the model in 2008 in an

urban school.

The “firsts” that VAEI celebrated in

2007 represent years of preparation

and continue the Institute’s mission

to impact science students locally

across the entire spectrum of

learning, and to impact the teaching

of science on a national level.

Gordon L. Van Harn, Ph.D.

Van Andel Education Institute Director

Van Andel Institute offers a full spectrum of training opportunities, supporting a continuum of learning that extends from elementary school to professional development.

K-12 > > >

Science Academy Out-of-

School-Time Program and

Science on Saturday

GRAPCEP: Grand Rapids

Area Pre-College

Engineering Program

College > > >

Frederik and Lena Meijer

Student Internship Program

GRMERC Medical Student

Summer Research Internship

Program

Bridges to the Baccalaureate

Graduate/Ph.D. > > >

VAI Graduate School

VAI-MSU Graduate

School Program

NIH T-32 Training Program for

Veterinary Students

Postdoctoral > > >

Postdoctoral Fellowships

Professional

Development

Science Academy

Classroom Science

Investigations

Educator Professional

Development

VAEI Director

www.vai.org

29


Van Andel Institute Graduate School

Convocation Commemorates Inaugural School Year

Van Andel Education Institute


On August 20, 2007, in a ceremony laden with pomp and

circumstance, attended by Van Andel Institute (VAI) officials,

faculty, students and their families, VAI Graduate School

ushered in its inaugural 2007-2008 school year with an opening

convocation held in Van Andel Institute’s Tomatis Auditorium.

The convocation commemorated the opening of the graduate

school, whose mission is to train Ph.D. scientists and leading

scholars in cell, molecular and genetic biology relevant to human

diseases, and marked the beginning of classes for its first class of

three graduate students.

The students, Natalie Wolters,

24, Brent Vander Hart, 25, and

Jeffrey Klomp, 26, work closely with

Van Andel Research Institute (VARI)

investigators, who serve as the

school’s faculty. Courses blend

traditional disciplines into a novel,

problem-based curriculum that

closely represents the way scientists

conduct research.

“These students are pioneers,

accepting the challenge and

opportunity of being the first cohort

of students in the VAI Graduate

School,” said VAI Graduate School

Dean Steven J. Triezenberg, Ph.D.

“We’ve chosen them because they

have the qualities that will enable

them to be leaders in various fields of

biomedical research.”

The students spent the first several weeks visiting each laboratory

in the Institute and subsequently began a series of eight-week

rotations in the laboratories of their choice, which will guide

them toward determining their dissertation topics by the end of

the first year.

Above: convocation ceremony, Opposite page (l to r): Brent Vander

Hart, VAIGS Dean Steve Triezenberg, Natalie Wolters, Jeffrey

Klomp

The students cite the graduate school’s emphasis on translational

research and its unique problem-based curriculum that closely

represents the way that scientists conduct research as determining

factors in their decision to attend.

“The classes will teach the basics of preliminary research, experimental

design, and communicative skills in a more innovative and practical

way than I saw anywhere else,” said Wolters. “Since the program is

new and the entering class is small, the content of our studies can be

focused to address our interests while maintaining a level of guidance

that will help us learn more quickly

than in a larger setting.”

The VAI Graduate School doctoral

program received an independent

charter from the state of Michigan

to confer advanced degrees and

focuses research on the biology of

various human diseases. Students

will obtain their degrees after

about five years of study.

Initial plans call for the admission

of two to four additional students

each year for the next five to six

years. Once current VAI expansion

is complete, the program would

recruit eight to 10 students per year

with ultimate capacity planned at

about 45 students.

“We recognize that the remarkable

advances in genetics over the last

decade have charted a new course in biomedical research and

medical practice,” said Van Andel Institute Chairman & CEO David

Van Andel in his opening remarks. “In response, we will use a novel

curriculum rooted in the practice of scientific research to educate our

best and brightest in the technology and techniques associated with

contemporary genetics.”

VAEI VAI

Graduate School

www.vai.org

31


Highlighting

and Supporting

Undergraduate Research

Research conferences aren’t usually held for undergraduates,

but on October 20, 2007, the new Van Andel Institute

Graduate School hosted the first annual West Michigan

Regional Undergraduate Science Research Conference. The

expansive Cook-Hauenstein Hall at Van Andel Institute (VAI) was filled

with rows of posters that approximately 120 students had created to

share their research with peers, faculty, and parents throughout the day.

Posters reflected a wide range of scientific disciplines, including

physics, chemistry, biology, computer science, ecology, hydrology,

endocrinology, neuroscience, evolution, and psychology. Students

also had a chance to hear from scholars and scientists currently

working in either academic or translational research fields, as well as

Dr. James Lightbourne, National Science Foundation senior advisor

for integration of research & education, who delivered the keynote

presentation.

“Reaching students at the undergraduate level, before they decide

on the direction of their graduate studies and careers, is the best time

to impart the real-world experience of a research conference that

participants enjoyed at this event,” said Steven J. Triezenberg, Ph.D.,

dean of the VAI Graduate School, which hosted and organized the

event along with Grand Valley State University, Calvin College, and

Hope College.

Posters from students filled the Cook-Hauenstein Hall at the Institute

Approximately 140 undergraduate students and 60 faculty from West

Michigan colleges and universities attended the conference. Attendees

included students from the organizing universities, as well as those from

Aquinas College, Ferris State University, University of Michigan, and

Grand Rapids Community College.

Triezenberg said that the conference is one way to help build the regional

intellectual community, and that students who might have otherwise left

the state to look for work also found out about career opportunities in

West Michigan.

Van Andel Education Institute


Internal Medicine Research Residency Program

Van Andel Institute Graduate School and the Grand Rapids

Medical Education and Research Center (GRMERC)

teamed up in 2007 to

launch the Internal Medicine

Research Residency Program, which

offers students a Ph.D. degree in

molecular and cell biology, and

state licensure and board eligibility

in internal medicine.

GRMERC is a medical, health education and research consortium

of the leading health care and education providers in Grand

Rapids and offers residency

programs in more than a dozen

areas. Its members include

Michigan State University,

Spectrum Health, Saint Mary’s

Health Care and Grand Valley

State University.

“Students completing their

medical school training who have

a passion for biomedical research

or translational medicine are well

suited for this program,” said

Steven J. Triezenberg, dean of

the VAI Graduate School. “They

already understand the clinician’s

perspective on human disease,

and our innovative curriculum

and programmatic flexibility can

develop their research skills.”

The program is designed to provide clinical and research training

to produce physicians that are prepared for careers as basic

science and clinical research scholars. Typically, participants

will complete two years of clinical rotations to permit licensure,

followed by approximately five years of Ph.D. classroom

and research experience. Clinical experiences will continue

throughout the research phase, and will typically account for 20

percent of the time.

(l to r) Steve Triezenberg and Matt Biersack

Throughout the Ph.D. program,

students will work closely with

Van Andel Research Institute

(VARI) investigators, who serve

as the school’s faculty. Courses

will blend traditional disciplines

into a novel, problem-based

curriculum with an emphasis on

translational research to provide

students a wider view of the

connections between academia,

clinical practice and the biotechnology and pharmaceutical

industries.

Matt Biersack, a 2007 graduate of Wayne State Medical School, is

the first participant in the program. He has completed his first year

of internal medicine residency training at Spectrum Health and

Saint Mary’s Health Care and will begin his Ph.D. training at VAI

Graduate School in 2009.

VAEI VAI

Graduate School

www.vai.org

33


New Programs at Science Academy

Engage Students, Educators, and Community

Van Andel Education Institute


The Van Andel Education Institute (VAEI) Science VAEI staff helped her to develop teaching methods that would

Academy launched in 2006 with an out-of-schooltime

inaugural program that leads cohorts of students

challenge each child.

through three years of hands-on science education. In 2007, the

Science Academy added two new programs: Classroom Science

Investigations and Science on

Saturday. The three programs

complement one another to

engage students, educators,

After discussion and planning sessions with Mooney, VAEI staff

developed curriculum and instructional assessment strategies

that they then modeled when

Mooney and her class came

to the Science Academy for

two half-day sessions. The

and the community in science

Chandler Woods students

and science education.

learned how an organism’s

form and function are related to

Classroom Science

Investigations

its environment, and designed

research to determine the

environmental preferences of

Classroom Science Investigations

is a professional development

pill bugs. In follow-up visits to

the school, VAEI staff provided

program for educators that

supplies for students to build

is unique in that the students

are involved in their teacher’s

professional development and

their own pill bug habitats

based on their research; the

visits also allowed staff to

learn science at the same time.

observe Mooney applying

“We are teaching students how

what she had learned. The

Above: 4th grade teacher Ruth Mooney and students, Opposite page (l to

to do research and teaching

students took habitats home

r): Science Education Specialist Marty Coon, VAEI Associate Director Marcia

teachers how to build content Bishop and Science Education Specialist Carole Johnson

to continue observation and

knowledge,” said VAEI Science

Education Specialist Marty Coon.

follow-up research and then

presented what they learned at Chandler Woods.

Teacher Ruth Mooney and her fourth grade students from Chandler

Woods Charter Academy were the program’s first participants in

May 2007. Classroom Science Investigations allows the teacher to

identify his or her specific area of focus based on specific challenges.

Mooney’s class was composed of a diverse array of learners, and

Chandler Woods Charter Academy Assistant Principal Barbara

Lindquist said that there has been enthusiastic response from

students, parents, and teachers. “I’ve got excited kids who want

to learn more, and teachers who want to be continuous learners,”

she said.

VAEI Science

Academy

www.vai.org

35


Van Andel Education Institute


Science on Saturday

Impact

Science on Saturday engages the community in science education by

inviting two-person teams of students and adults to participate in one

two-hour Saturday session. The first sessions were held on Saturday,

October 13, 2007. Teams rotated between three stations: lab, bearded

dragon area, and turtle area.

In the lab, students and adults investigated organisms such as crayfish,

hissing cockroaches, millipedes, and pill bugs. At all stations, they used

tools such as microscopes, probes, and balances to answer questions

about the organisms (How much do they weigh? How long are they? What

do they like to eat? What is their body temperature? How do they move?).

Expanded sessions will be offered in 2008 due to popular demand.

By including a parent or other significant adult in students’ lives

(grandparent, aunt, uncle, guardian, mentor, etc.), Science on Saturday

brings the Science Academy’s offerings full circle. Students, teachers, and

now role models are all engaged in science education, and are receiving

the tools necessary to advance students toward careers in science.

Through these and future programs, VAEI staff analyzes

how students learn science; the goal is to share this

knowledge with other educators, making a national

impact. “This is an ongoing research laboratory,” said

VAEI Associate Director Marcia Bishop. “Everything

we do is intentional and designed around how people

learn.” Improving science education and increasing

the number of students who choose careers in science

will help to reverse the findings of numerous national

studies that conclude that the United States is losing

its preeminent position in science and technology.

“Everything we do is

intentional and designed around how

people learn.”

—Marcia Bishop, VAEI Associate Director

VAEI Science

Academy

www.vai.org

37


A Letter from Joe Gavan

Vice President, Communications & Development

While Van Andel Institute stands out in the Grand

Rapids skyline for its beautiful architecture and in

the world of science for its many accomplishments,

it is only as a member of a deeply committed community that we

can fulfill the promise of our mission to improve the health and

enhance the lives of generations to come.

I wish that I had space in this letter to thank each and every

individual who has played such a key role in funding our important

mission, attending, sponsoring and helping to organize our full

slate of events throughout the year and volunteering their time

and energy to act as the Institute’s ambassadors to the world at

large. These friends deserve our recognition and thanks, and are

listed on the pages that follow.

I would, however, like to single out the members of the Bringing

Hope to Life Campaign Steering Committee and its Co-Chairs

John and Marie Canepa, Jim and Kathy Hackett, Kyle and

Win Irwin, and Mike and Sue Jandernoa for their exemplary

leadership and hard work in helping the Institute to launch its

first major gifts campaign in October 2007.

Philanthropy & Development

Support for Van Andel Institute comes in many forms. Every gift makes a difference at

Van Andel Institute, because every dollar goes directly to research and education.

Van Andel Institute


2007 was a groundbreaking year in so many ways for Van Andel Institute

that it is easy to overlook the fact that Bringing Hope to Life is the

Institute’s first campaign of its kind. The goal of Bringing Hope to Life is

to raise a minimum of $10 million by December 2009, to fund the creation

of a Parkinson chair, the expansion of pioneering research and education

programs not covered by grant funding,

and renovations to Crescent Park.

The deeply committed philanthropic

community of West Michigan has had no

difficulty in recognizing the connection

between the Institute’s commitment to

basic and translational research and the

treatments that have the potential to

change the lives of patients. By the end

of 2007, the campaign was well on its

way to achieving its goal with pledges

totaling $2.4 million.

It is easy to glance at a litany of statistics

and see the need: as life expectancy

increases, the incidence of cancer, Parkinson and Alzheimer’s disease

increases at an alarming rate. Nearly 600,000 Americans died from

cancer in 2007; 1.5 million Americans currently have Parkinson

disease; five million Americans are living with Alzheimer’s disease,

and the odds of diagnosis double every five years beyond age 65.

Philanthropic investment in support of Bringing Hope to Life is essential to fund:

Novel Research & Inquiry-Based

Science Education Programs

> > > $5 million

Highly promising research such as our

Compassionate Care Protocol (pg. 24) and

expanded programs for students across the

entire continuum of learning

The Jay Van Andel Parkinson

Research Lab

> > > $4 million

The endowment of Jay Van Andel Parkinson

Research Chair, the recruitment of a scientific

investigator, and the purchase of state-of-theart

equipment

Our supporters understand that a commitment to basic research

now will have a measurable effect on these statistics in the long

run.

But they also have the imagination to envision the project’s

impact on individuals, which is

practically immeasurable. For there

has yet to be a metric devised to

calculate the value of such outcomes

as an enhanced chance at life for a

cancer patient, the spark of passion

engendered in the scientists of

tomorrow, or the peace and relaxation

that a renovated Crescent Park might

afford visitors.

We thank you for your continued

support and your commitment to the

future.

Joseph P. Gavan

Vice President, Communications & Development

Crescent Park - Bringing Hope

to Life Gathering Place

> > > $1 million

A place for friends, families, students, and

colleagues from throughout the community

to gather to celebrate triumphs and reflect on

challenges

VAIVP, Communications & Development

www.vai.org

39


Hope on the Hill Donor Recognition

Hope on the Hill

Society

The following reveals those donors

whose cumulative giving has grown

over the years to levels beginning at

$25,000. To them, Van Andel Institute

extends our deep appreciation. You have

helped us grow during our start-up years.

Thank you.

Founders Society $1 million & above

John and Nancy Batts

Peter C. and Pat Cook

Richard and Helen DeVos

Ralph W. and Grace▲ Hauenstein

Sidney J. Jansma, Jr. and Joanne▲ Jansma

Fred and Lena Meijer

Jay and Betty Van Andel Foundation

Legacy Society $500,000 to $999,999

McCarty Cancer Foundation

Leadership Society $250,000 to $499,999

David and Carol Van Andel

Patrons Society $100,000 to $249,999

Fifth Third Bank

Howard Miller Company

Rockford Construction

The Bernice Hansen Charitable Foundation

John C. and Nancy G. Kennedy

The Wege Foundation

Huntington Bank

Benefactors Society $25,000 to $99,999

Allied Mechanical Services, Inc.

Amble Motorcycle Group

Raymond and Alice Andrews

James and Shirley Balk

Blue Cross Blue Shield of Michigan

Carol Bylsma

Cancer & Hematology Centers of Western MI, PC

John and Marie Canepa

The Currie Foundation

Daniel and Pamella DeVos

Lawrence and Nancy Erhardt

Grand Valley State University

Christian Helmus ▲

Hoffman Jewelers

J.C. and Laurie Huizenga

William and Beatrice Idema

Mike and Sue Jandernoa

Johan’s TriFest

LaSalle Bank - West Michigan

Robert J. and Cindy McCann

Mark D. and Mary Beth Meijer

The Meijer Foundation

Meijer Inc.

Merrill Lynch - The Veldheer, Long, Mackay,

& Bernecker Group

Michigan State University

- College of Human Medicine

Miller Johnson

William W. and Sandi Nicholson

RORDOR Foundation

Fritz M. and Carol Rottman

Darell and Mary Schregardus

Secchia Family Foundation

L. William and Sarah Seidman

George Sietsema

SMG Van Andel Arena

John and Judy Spoelhof Foundation

Richard and Pauline Stark Estate

Steelcase Inc.

Teazers Bar & Grille

Universal Forest Products Inc.

Stephen and Cynthia Van Andel

George and Dot Vande Woude

Varnum, Riddering, Schmidt & Howlett

Verizon Wireless

Johan Visser ▲

Casey and Violet Wondergem

Society of Hope - Deferred Gifts

Philip and Shirley Battershall

John and Nancy Batts

Patrick and Janie Kelly

Tim and Kim Long

Jamie Mills

George Sietsema

Eva Sonneville

Fred L. Tape

John Van Fossen

Hope on the Hill Donors

Van Andel Institute’s Hope on the Hill donors

include those who gave annual gifts or sponsored

many of our successful events between January 1

and December 31, 2007. At the Institute, we hold

the premise that EVERY dollar counts, EVERY

dollar makes a difference, and EVERY donor is

equally important and valued regardless of level

of giving. Please accept our ongoing thanks.

Grand Donors $10,000 and above

Amway Grand Plaza Hotel

Blue Water Technologies

Peter C. and Pat Cook

Jerry and Karen DeBlaay

Daniel and Pamella DeVos

Dick and Betsy DeVos

Richard and Helen DeVos

Andrew Dykema

Fifth Third Bank

The Bernice Hansen Charitable Foundation

Ralph W. and Grace▲ Hauenstein

Hoffman Jewelers

Howard Miller Company

Huntington Bank

Mike and Sue Jandernoa

Sidney J. Jansma, Jr.

John C. and Nancy G. Kennedy

John and Nancy Kennedy Family Foundation

LaSalle Bank - West Michigan

Mark D. and Mary Beth Meijer

The Meijer Foundation

Merrill Lynch - The Veldheer, Long, Mackay,

& Bernecker Group

Michigan Elks Association

Michigan State University

- College of Human Medicine

Rockford Construction

Schering Plough

Darell and Mary Schregardus

Secchia Family Foundation

The Seidman Family Foundation

George Sietsema

Richard and Pauline Stark Estate

Universal Forest Products Inc.

Dave and Carol Van Andel

Dave and Carol Van Andel Foundation

Ina June Vander Veer

Verizon Wireless

Patron Donors $5,000 to $9,999

97 LAV

James and Shirley Balk

Charles and Christine Boelkins

The Bouma Corporation

Cancer & Hematology Centers of Western MI, PC

John and Marie Canepa

The Chop House

Crowe Chizek

The Currie Foundation

Douglas and Sandra Dekock

Dwight Reed Memorial Golf Outing

Ernst & Young LLP

Grand Rapids Magazine

Grand Valley State University

Martin and Peggy Greydanus

Grubb & Ellis | Paramount Commerce

J.C. and Laurie Huizenga

Hunt/Owen-Ames-Kimball Co.

Earle S. and Kyle Irwin

Leigh’s

Tim and Kim Long

Lord, Abbett, & Co. LLC

Macatawa Bank

Robert J. and Cindy McCann

Metro Health

Mills Benefit Group, LLC

NAYA Bistro & Wine Bar

Peter and Sheila Neydon

Randall L. Phelps

Plante & Moran, PLLC

Dirk Hoffius

Estate Planning Attorney, Varnum, Riddering, Schmidt and Howlett

“People often say to me ‘We want to invest our estate

gifts in organizations we know will remain strong

long after we pass away. To us, strong endowments

equate to a strong future.’ When I hear comments

like that, I think of Van Andel Institute.”

Preusser Jewelers

Fritz M. and Carol Rottman

Saint Mary’s Health Care

SMG Van Andel Arena

John and Judy Spoelhof Foundation

Duwane A. and Sue Suwyn

Michael and Michelle Van Dyke

Varnum, Riddering, Schmidt & Howlett

Warner Norcross & Judd LLP

West Side Beer Distributing

Greg and Meg Willit

WOOD TV

X-Rite

Bronze Donors $2,500 to $4,999

Accident Fund of Michigan

Amerisure Insurance

Applause Banquets & Catering

Axios Incorporated

Michelle and Kevin Bassett

BDO Seidman, LLP

Berends Hendricks Stuit

Better Life Unlimited

Marcia and Richard Bishop

Blue Cross Blue Shield of Michigan

Broadmoor Products, Inc.

James and Donna Brooks

Jerry and Susan Callahan

Christman Company

Comerica Bank

Davenport University

Deloitte & Touche, LLP

Dickinson Wright PLLC

Paul and Mary Jo Drueke

Ferris State University

David G. and Judy Frey

Grand Rapids Community College

The Grand Rapids Press

The Granger Group

Great Lakes Computer

Holland Community Hospital

Ice Sculptures LTD

Insignia Homes

Robert and Paulette Israels

Jewish Communal Fund

The Jubilee Foundation

Jim and Ginger Jurries

Kathleen & Company

Craig and Deb Kinney

Donald and Elizabeth Klopcic

KO Sports

Van Andel Institute


Lake Michigan Credit Union

Leo’s

Marsh USA, Inc.

Mc Shane & Bowie

Meijer Inc.

Henry and Mary Morley

John and Barbara Myaard

National City Bank

Norris, Perne and French LLP

John and Gail Nowak

Price, Heneveld, Cooper, DeWitt & Litton LLP

Progressive AE

Root Lowell Manufacturing Co.

William J. and Sally A. Rothwell

Alan and Margaret Ryan

Smith Haughey Rice & Roegge PC

Spectrum Health

Steelcase Inc.

Wells Fargo N.A.

West Michigan Science and Technology Initiative

Charter Donors $1,000 to $2,499

Attallah and Mimi Amash

James▲ and Marilyn Bambourough

Bar Divani

Frank D. and Judith Beltman

Edward W. and Joan G. Berends

Betz Industries

David and Jill Bielema

BioTechConnections.org/Gary and Sandra Burmeister

Fred and Elaine Borgman

John and Sharon Bouma

Donald R. and Frances L. Buske

Gaylen and Susan Byker

Carol Bylsma

Cascade Rental

Jim and Jennifer Conner

Dave and Karen Custer

Robert and Katherine Daverman

James and Joy DeBoer

Bill and Terri DeBoer

Jeff Dykehouse

Bill and Diane Ehinger

Ken and Frances Ellis

James B. and Gail M. Fahner

Feyen-Zylstra LLC

Margaret H. Fondren

Forest Hills Foods

R. Jack and Mary Frick

Dan and Lou Ann Gaydou

Robert and Paula Geyer

Elizabeth Gillett

The Gilmore Collection

Gene and Tubie Gilmore

Gerald and Jane Girod

Norma Girod

Richard and Ethelyn L. Haworth

Haworth Inc.

Steve and Brenda Heacock

John and Gwen Hibbard

The Hip Pocket

Phil T. Hoekstra

Dirk C. and Victoria Hoffius

Earl and Donnalee Holton

Hope College

David D.▲ and Marilyn Hunting

Roberta L. Jones

Paul and Diane M. Jones

Joe and Elizabeth Junewick

Fred and Linn Keller

Kerkstra Precast, Inc.

Lawrence and Anne Kloth

L & V Development

Lacks Enterprises, Inc.

Leelanau Cellars

Bill and Sharon Lettinga

Ray and Nancy Loeschner

Charles W. Loosemore Foundation

Gary and Vicky Ludema

Leonard and Marjorie Maas

Materials Testing Consultants

Hank and Liesel Meijer

Jack H. Miller

Miller Johnson

Mark and Elizabeth Murray

Paul Nickodemus

Mark and Judy Olesnavage

Donald and Ann Parfet Family Foundation

The Peninsular Club

Charles J. and Nancy J. Poquette

Edgar & Elsa Prince Foundation

Drake Quinn Family Foundation

Regal Limousine Service

Carl and Francesca Rehnborg

James and Christine Resau

RORDOR Foundation

Alywn and Chris Rougier-Chapman

Chuck and Stella Royce

Jacquolyn Sawyer

Roger and Kathleen Schiefler

Joel Schoon Tanis

Audre Seale

Budge and Marilyn Sherwood

Brent and Diane Slay

David Smith and Peggy Child Smith

James and Jacquelyn G. Sobieraj

Thomas L. and Mary L. Stuit

Russel and Jean Swaney

Bill and Sally Swets

Marilyn Titche

Steven and Laura Triezenberg

Two Chicks and an Oven

Dan and Ann Marie Van Eerden

John Van Fossen

Gordon and Mary Van Harn

Gordon and Margaret Van Wylen

George and Dot Vande Woude

Stuart and Nelleke Vander Heide

Theodore S. and Joan A. Vanderveen

David and Tillie VanderVeen

Lewis and Norma VanKuiken

Kathleen and Phil Vogelsang

Dan Vos

James C. and Sue Williams

Carolyn W. and Lawrence Witt

Tim and Kris Wondergem

Michelle Van Dyke

Regional President, Fifth Third Bank Michigan | President and CEO, Fifth Third Bank Western Michigan

Partners in Hope $500 to $999

William Alt

R. Tony and Kathleen Asselta

Guy S. Bailey

Robert P. and Valerie Bernecker

Grace Bouwman

Bradford Company

Cascade Engineering, Inc.

Ken Coryell

Wayne Coryell

Bert and Lindy Crandell

Dori Drayton

Nicholas and Susan Duesbery

James and Kathy Dunlap

Mark and Anne Elve

John and Marcia D. Evans

Mat and Jennifer Fahrenkrug

John Fitch

Funny Business Agency, Inc.

Goodwill Industries

John and Liga Greenfield

Sheryl Haverkate

Days Inn Hotel

Bill Hazard

Stephanie L. Hehl

Dan and Diane Hickey

Hoe Down Hoggs 4H

Hospice of Michigan - Greater Grand Rapids

Johan’s Trifest

Carol Karr

Kevin Paul and Mid Life Crisis

Philip and Lillian Koning

Nicholas and Gloria Kroeze

Pamela Luetkemeyer

Lukens Family Foundation

William S. and Amy M. Mackay

John and Suzanne MacKeigan

Michigan Community Blood Centers

Monica’s Best Gourmet Cookies

Pam and Mike Murray

Jeffrey R. and Erin M. Needham

Mike and Bette Oostendorp

Oliver and Donna Owens

Seymour K. and Esther Padnos

Mark and Dianne Peters

Pine Rest Foundation

Pioneer Construction

Priority Health

Norman and Janet Pylman

John and Therese Rowerdink

Janice Talen

Thompson Remodeling, Inc.

Roger Tjoelker

Nancy Van Andel

William D. and Yvonne H. Van Ee

James D. and Maryanne Veldheer

Craig P. and Tara Webb

Richard A. and Diane R. Wendt

Gretchen White

Bart and Wendy Williams

Friends of the Institute $1 - $499

Dave and Lee Ann Abel

Vincent A. and Mary M. Ackerman

AD Bos Vending Services

Art and Lisa Alberts

Tom and Jean Almy

Alticor Inc.

Peter and Lilah Ambrosi

Sandra Ames

Catherine Amodeo

Heather Anderson

Larry and Nancy Andreano

James E. and Francene M. Angers

Applied Imaging

Leann Arkema

Jeff Asfour

Robert Atkinson

Charles F. and Jane S. Aylsworth

Philip J. and Joanne L. Baker

Steven G. and Marguerite H. Baker

John, Evie, and Tommie Barfuss

Thomas and Tamara Barney

Duane Bartee

Bret Bartee

Dick Bartulis

Jean Bassett

Chris L. and Brenda Bauchan

Guy Beck

Brian Beckett

Don Beenen

Donald E. and Eunice L. Berry

Mike and Donna Bieker

Biggby Coffee

George Bischoff

Ron Blair

Charles M. and Patricia A. Bloom

Kimberly Joy Bode

James and Priscilla Boike

William M. and Donna G. Boorstein

William J. and Judith L. Booth

VAI Donor

Recognition

“Hope is the most special gift we can give to the people around us, in our close circles, our neighborhoods, and our world. And believe

me when I say there is a lot of hope being generated at Van Andel Institute. That is why Fifth Third Bank is proud to be title sponsor of

the Van Andel Institute Celebration of Hope for the seventh year in a row. As the bank of the community, Fifth Third Bank donates millions

of dollars each year to enrich the lives of people in the communities we serve. Unfortunately, cancer and Parkinson disease touch so many

people in our communities. We view Van Andel Institute as a critical link in connecting our dollars to community needs.”

www.vai.org

41


Friends of the Institute

(continued)

Tammy Born

Born Preventive Health Care Clinic, PC

Vern and Norma Boss

Pamela J. Bouma

Michael and Beth Bouma

Melissa L. Bourke

Mary Bouwkamp

Eileen Brader

William and Barbara Bradley

James H. and Sheral Bradley

Jacqueline Bradley

Esther Brandt

Richard Breukink

Sallie and David Brinks

Broadway Grand Rapids

Jaime Brookmeyer

James C. and Ellen J. Bruinsma

Roger and Connie Brummel

Edward and Sarah Buck

Mark Bugge

Bullseye Group

Robert Burch

Janelle Burden

Sue A. Burns

Yvonne M. Burns

Thomas and Stacey Buschert

William H. and Jackie Bylenga

Bruce and Jan Bylsma

Robert L. and Shirley Ann Bytwerk

Douglas C. Camelo

Bryon L. and Kandy Campbell

Don and Lois Capel

Stephen F. and Michelle Card

Benjamin and Cortney Carlson

Nancy L. Carlson

Edward and Maureen Carlson

Gregory Cavey

Linda Chamberlain

Ron and Joann Champion

Jack and Donna Chase

Kevin and Kelly Chopp

Thomas and Nancy Church

Mike and Kim Clarke

Arthur A. Clements

David J. Closs

Christopher Coats

Commerce Realty and Management Company

Consolidated Electrical Contractors

Contemporary Glassworks

Marty and Barbara Coon

Dwayne Coryell

James and Cynthia Cotter

Bruce Courtade

Howard T. Courtnay

Charles and Laura Cox

Allen Crater

Michael J. Crawford

The Creelman Agency

Russell and Alice M. Cronberg

William and Janice Currie

Brenna Cusack

Charlie and Linda Cusack

Bruce Custer

Jim and Judy Czanko

Ronald and Cindi J. Czarnecki

Joseph D’Ali

Chico and Vanessa Daniels

John D. and Rene Darling

Arnold D. and Ilene D. Dashoff

Jennifer M. Daugherty

Amy and Curtis Davis

Jason and Cindy Dawes

Daybreak Studios

Jeff and Jill Dean

John and Jane Dean

Michael J. DeBoe

Vance C. and Barbara J. DeCamp

Don and Doris DeGood

Thomas A. and Robin D. Demeester

Robert DeVilbiss

Nancy C. and Ken Devon

Lora DeVries

Gary and Joyce DeWitt

Digital Video Services

Robert Doane

Michael B. and Renae D. Donahey

Elizabeth A. Donley

Stephen and Michelle Doyle

Richard M. and Cheri L. Dressler

Brandt D. and Sharon M. Driscoll

Thomas B. and Mary Duthler

Dwelling Place of Grand Rapids, Inc.

Michael and Mary Dykema

Chester Dykema

Dave and Pat Edwards

Vernon J. and Johanna Ehlers

Kathryn M. Eisenmann

Elders’ Helpers

John F. and Teresa A. Elliott

Mark and Jennifer Ellis

Michael S. and Lynette Ellis

Sharry A. Fearon-Beatty

R.K. and Char Fecho

Carole Feigley

Edwin and Linda Feulner

Paul and Charlene Fitzpatrick

Mike Flynn

Maureen E. Foley

John and Mylinda Folkert

Suzette Foll

William L. and Mary Ford

Forest View Psychiatric Hospital

John and Jodie Formolo

Betty Jane Forray

Carl and Anne Forslund

Albert and Laurie Forte

Ken Fowler

Lynn and Alice V. Francis

Randall and Amy Freeburg

Florence Freeman

Dave & Karen Custer

Custer Workplace Interiors

“There are many good causes to give to, and it is impossible to support

all of them in a meaningful way. Thus, we focus our giving on Healthcare

and Education. Van Andel Institute fits perfectly into both areas. This is very

appealing to us.”

Eleanora H. Frey

Linda Frey

Lisa Freybler

Charles T. and Carol A. Fridsma

Sarah Friedman

Julia B. Fry

Joseph and Susan Gavan

General Glass Corp

Chad M. Genton

Jared E. and Linda J. Gieske

Lynn and Zell Gill

Craig Glupker

Philip W. and Jane Goodspeed

Goodwin Procter

Elaine Goralski

Shelly D. Gordon

Jim Gordon

Sandra Gores

Terri G. Gorton

Grand Action

Grand Rapids Area Chamber Of Commerce

Grand Valley Health Corporations

James O. and Mary E. Grant

Sharon Greider

Chester H. Griffis

Mary M. Grigware

Colleen Grimes

Edythe R. Grinage

Patti Griswold

Christine Gutierrez

Elizabeth Haak

Pete Haak

David and Gloria Haebich

Betsy Haller

Julia Hamming

Jon Hanson

Kimela Hardy

Richard J. and Lillian Havenga

Ruth Haverkamp

Tim Hawkins and Ilsy Murillo

Health Unlimited

Bary Hearon

Ted and Amy Heilman

Henry A. Fox Sales Co.

Thomas G. and Maureen Herman

Robert and Barbara Herr

Bruce Heys Builders, Inc.

Mark Hiesterman

Randy Hillard

Larry J. and Candace A. Hillis

Ken Hinton and Nancy Devon

Dennis and Jeni Hoekstra

Michelle M. Hoexum

Hoffman Jewelers

Ronald and Heidi Hofman

Laura A. and Matt Holman

Cynthia Holmes

Eric J. Hoogstra

John and Mary Hoogstra

Dan and Amy Horning

Robert E. and Beatrice Horton

Donald R. and Ruby W. House

Margie and Timothy Hoving

Larry L. and Ginger Howe

Joanne Hunefeld

William and Susan E. Hunt

Lourie Hurley

David and Joyce Ignasiak

Ron Igrisan

Jose A. and Sue Infante

Lyle R. and Jacqueline J. Irish

James and Sandra Jackoboice

Thomas J. and Barbara A. Jackoboice

Holly Jacoby

Roland Jager

Don and Lois Jandernoa

Melissa M. Janes

Helen K. Jansen

Jarob Design

Angela R. Jason

JB2 Enterprises

Linda C. Jennings

Michelle Jespersen

Maryanna Johnson

Eric E. Jones

JP Morgan Private Bank

Kevin Kaifer

Robert F. Kaiser

Dafna and Greg Kaufman

David Kaufman

Alex Kayzerman

David Keenan

Kelly Scientific Research

John and Carri Kendall

Mark Kennedy

Kent Beverage Company Inc.

Judith L. Kessel

Robert P. and Katherine H. Kimball

Donald M. and Monica M. Kimball

Adam King

David R. and Melissa Klein

Norman and Valerie L. Knapp

Deborah Kober

Katherine Koehler

Julie Koenig

Linda L. Koert

Joseph W. and Mildred Konrath

Jerry and Maribeth Kooiman

Michael Koppinger

James D. Kozal

Van Andel Institute


To make changes to how your name(s), or

your company’s name, is listed in future

publications, please call 616-234-5681.

Diane Kozal

Bernadine Kozal

Dennis and Joanne Kozarek

Richard Kraklau

John and Arnette Kraus

David and Jane Krombeen

Rebecca Krueger

Frederick R. and Sharon L. Kruithof

Karen Kuiper

Christian T. Kutschinski

Greg and Susan Lambert

Jeannine Lanning

Kari A. LaPlaunt

Betty J. Laroux

Joseph Lattanze

Kaye LaVee Swanson

Lorraine Lavigne

Kellie A. Leali

Sid Lee

Lee Special Systems

John and Mary Leese

Amy LeFebre

Larry Leigh

Leigh’s

Edward Lewis

Robert C. and Frances V. Lewis

Joby and Amanda Lewis

Scott and Nancy Liversedge

Benjamin and Denice Logan

John H. and Susan Logie

Laura and Dennis Lohr

Allan C. and Barbara J. Lowe

Ric and Lisa Loyd

Irving J. Lundell

Heather T. Ly

Jeff and Shannon MacKeigan

Richard and Mary MacKeigan

Kevin R. and Jill Mahoney

Donald W. and Kathleen Maine

Luma Makhay

Dolores Malec

Nicholas Malec

Gloria Mance

Robin and Yvonne Mancuso

James and Elizabeth Mandarino

George Manus

Marina Shores Association

Jack W. and Delores Marks

John and Nancy K. Markward

Joseph Marogil

Cynthia L. Martin

Henry and Connie Mast

Sally Matecun

John W. and Sharon Matthews

Andrea McAlhany

Joe and Darla McAlister

Mike McCoy

Jennifer and Justin McGrail

Gary and Linda McInerney

McInerney Law Offices PC

Ward J. and Shirley McKenney

Mary Jane McWilliams

Gary and Marlene Mescher

R. George Mickel

Mika, Meyers, Beckett & Jones, PLC

Julie Milanowski

Howard D. and Loraine Miller

Steve and Julie Miller

Bud and Jane Miller

Cynthia and William Miranti

Joe and Tracey Moch

Dan Modzeleski

David J. and Cathy Monsma

Brian and Susan Mooney

Bill Morgan

Kirk Morgan

David W. and Diana Morgenstern

Jeff and Denise Morton

William and Bernadette Motiska

Louise Mueller

Brent and Melisa Mulder

Gordon Mullholland and Kathleen Seglund

Fabienne Munch

Timothy and Denise Myers

David E. Nadziejka

Scott and Linda A. Nash

Claude and Gay M. Nauta

Chris and Molly Nawrocki

Edwin J. and Dolores Nawrocki

Gretchen Neering

Jeffrey Neiman

Charles and Suzanne Neureuther

Kristan A. Newhouse

David, Kristen, Grayson, Beck, and Alec Norris

Thomas W. and Jane A. Norton

Richard and Kathleen A. Noskey

Bob Novy

Nurture by Steelcase

NuSoft Solutions, Inc.

Sandra S. and Jack Oato

Chris O’Brien

Ruth O’Keefe

Steven Olson

Michael, Kristina, and Aidan O’Meara

Mr. and Mrs. Jay O’Neal

Dustin P. and Kim Ordway

James and Carolyn Oswald

Linda Otis

Irene Ott

Ron Ott

Danielle Ouendag

Philip and Denise J. Overway

John Pace

Jeffrey and Peggy Padnos

Frank Padron

Panera Bread

George Pantlind

Les and Barb Parker

Steve and Molly Parker

William L. and Barbara Parker

Passaro & Kahne Law Office, PLLC

Steve and Ruth Pate

Donald and Patricia Patterson

Ronald and Mary Patzer

Caroline Patzer

Robert and Karen S. Pearson

Gerald and Donna Pechtel

Louis J. and Cornelia R. Pepoy

Nancy Peters

Stephen Peterson

Thomas W. and Christine M. Pfennig

Timothy J. and Pamela Pietryga

Lisa G. and Gustavo Pilon

Bonnie Pinder

Pine Rest Christian Mental Health Services

Samuel J. and Cheryl Pinto

Michelle Plumer

Lynn L. Plummer

Angie and Brad Plutschouw

Rick and Sue Polhill

James and Kathleen Ponitz

Joseph G. Popiel

Amy Poplaski

Wendy Popma

David and Amy Poquette

Brian and Jennifer Post

Rodney and Amy Prahl

Mary Ann Prisichenko

Promega Corporation

Tony and Dianne Pung

Matt and Susan Quada

David Quigley

Quimby Walstrom

Christopher Rabideau

Angela Rambo

Robert H. and Andrea Rander

Tom Ranville

Michael Rapier

Carol G. and Steven Rappley

Mary K. Redman

David Reed

Gordon J. and Jeanine Reeder

Regent Broadcasting

Robert and Donna Renkema

Sue Anne Renken

The Right Place, Inc.

Ed Rodenhouse

Brian and Sandra Roelof

Thad Roelofs

Ronald R. and Joyce A. Rogers

Louis and Mary Romence

David L. and Jessica Ross

Anne Rossi

Kirk and Lynn Rottschafer

Veronica Rozelle

Carl R. and Shawn M. Ruetz

Jeffrey S. and Pamela B. Rush

William, Kathryn, Lauren and Kate Ryan

Denise Ryskamp

Jack and Dorothy Ryskamp

Fredric E. Ryskamp

James R. Saalfeld

Gerald Sajewski

Richard C. Salzwedel

Susan Samrick

San Chez Bistro

Elizabeth Sarafis

A. Charles and Caroline L. Schaap

Marsha Schmuker

Ann L. Schoen

Bill Schoonveld

Jeff and Susan Schreur

Matt Schulte

Clarence Schumaker

Darryl and Dawn Schumaker

Stephanie A. Scott

Sebastian Foundation

Secchia Institute for Culinary Education

Jaime Sekerke

Christine Serne

Dan and Susan Serne

Jeanne C. Serne

Michael S. Serne

James A. and Eleanor L. Serne

Mike and Joann Serne

Patrick A. and June H. Serne

David B. Shane

A. Michael and Terri L. Shapiro

Jerry and Kathy Shear

John and Mary Sheets

Robin Shelley

Jerry and Shirley Sherman

A. Clare and Karen Silva

Nancy Skinner

Larry L. and Marika Slenk

Shane and Meredith Smedley

Jonathan L. and Betsy Smith

Louis G. and Terry K. Smith

Smith Barney, Inc.

Sara Smolenski

Margaret M. Sowerby

Spartan Graphics

David and Linda Spencer

Richard and Lisa Spotts

Tina Sprich

William A. and Sandy Stevenson

Keith N. and Sheryl S. Stewart

Stifel, Nicolaus & Company, Inc.

Chris Stimson

Robert and Brenda Stineman

Marlene Stoops

Jerome P. and Judith H. Subar

Drew Sutton

Thomas C. and Susan Swaney

Pamela J. Swiatek

Sandy Swiatek

Zachary Talen

Dick and Shirley Tedford

Kathryn Teesdale

Bin and Jane Teh

Richard D. and Julie K. Terhaar

Jodi Termolen

Daniel Terpsma

Nicole M. Tessari

Brad E. and Elizabeth Thomas

John and Lydia Tobian

William D. Tolbert

Jose Toro

Bruce and Angela Towne

Rick Treur

John and Cheryl Tully

Peter M. Turner

T.W. Hager Lumber Co.

Urban Mill

Janice Uzarski

Michael Van Genechten

Jim and Kris Van Heule

Earl and Pat Van Opstall

Dave and Beth Van Portfliet

Gary and Debra Van Solkema

Clare and Joan Van Wieren

Jeffrey J. and Nancy Van Winkle

Cynthia Vande Woude

Arie and Jane Vandermale

VAI Donor

Recognition

www.vai.org

43


Friends of the Institute

(continued)

Russell L. VanderMey

Donald L. and Janell VanDine

Erin VanEpps

Lynn Vanpelt

Mike and Bev Vantieghrem

Varnum Consulting

Carl and Sandra VerBeek

Bill Vierregger

Jennifer Vogel

Theodore and Vicki Vogt

Raymond and Mary Lou Vreeland

Wachovia Securities, Inc.

Tracey Walker

Dee Wall

Cynthia Anne Walsh

Michael Warber

Amy Ward

John and Mary Beth Wardrop

Bill and Patricia Waring

Sandra K. Warren

Kirsten Washburn

Water Fight

Robert Weatherford and Pamela Stark

Michael Weinreich

J.L. Wentland

Ralph O. and Diane Wessel

Western Michigan Pediatrics Cardiology Associates, PC

Michael Whalen

Brian and Kim Whitson

Whitson Insulation Co. of Grand Rapids Inc.

Scott and Rebecca Wierda

John and Jill Wierenga

John and Marge Wiersma

Rita Williams

Bruce Williams

Robert and Carrie Winter

Howard H. Wirt

Stan J. and Phyllis Wisinski

Les and Lori Wisner

Tom and Lori Wisner

Don and Suzanne L. Wisner

Shirley Wohler

Gregory and Tina Wolbers

John M. Wolf

Joan Wolverton

Casey and Violet Wondergem

Leslie and Jane Wong

Larry and Bonnie Wormmeester

WZZM 13

Eric and Shawna Xu

Alan and Wendy Yamaoka

Michael and Leslie Yoder

Jameson and Meghan Yoder

Ron Young and Heather Frazee

David Young

Vicki Young

John J. Young

Barbara A. Youngblood

Linda Zarzecki and Dr. Liam Sullivan

Thelma Zeinstra

Rachael Zhang

William and Judith Zinser

Mitchell A. Zoerhoff

William R. and Carole E. Zoller

Lodewyk P. and Joanne Zwarensteyn

Employee Donors

Art and Lisa Alberts

Thomas and Tamara Barney

Michelle and Kevin Bassett

Marcia and Richard Bishop

Jaime Brookmeyer

Douglas C. Camelo

Bryon and Kandy Campbell

Benjamin and Cortney Carlson

Gregory Cavey

Marty and Barbara Coon

Jennifer Daugherty

Amy and Curtis Davis

Jason and Cindy Dawes

Nicholas and Susan Duesbery

Kathryn M. Eisenmann

R. Jack and Mary Frick

Sarah Friedman

Joseph and Susan Gavan

John and Liga Greenfield

Elizabeth Haak

Pete Haak

Kimela Hardy

Tim Hawkins and Ilsy Murillo

Steve and Brenda Heacock

Stephanie Hehl

Ted and Amy Heilman

Laura and Matt Holman

Margie and Timothy Hoving

Angela R. Jason

Roberta L. Jones

Dafna and Greg Kauffman

Katherine Koehler

Christian T. Kutschinski

Kellie A. Leali

Laura and Dennis Lohr

Heather T. Ly

Jeff and Shannon MacKeigan

Jennifer and Justin McGrail

Cynthia and William Miranti

David and Cathy Monsma

Brent and Melisa Mulder

Pam and Mike Murray

Timothy and Denise Myers

David E. Nadziejka

Mr. and Mrs. Jay O’Neal

Lisa and Gustavo Pilon

Samuel and Cheryl Pinto

Angie and Brad Plutschouw

Amy Poplaski

Carol and Steven Rappley

James and Christine Resau

Thad Roelofs

David and Jessica Ross

Ann L. Schoen

Stephanie A. Scott

Pamela J. Swiatek

Bin and Jane Teh

William Tolbert

Jose Toro

Steven and Laura Triezenberg

John Van Fossen

Gordon and Mary Van Harn

George and Dot Vande Woude

Russell L. VanderMey

Kathleen and Phil Vogelsang

Craig P. and Tara Webb

Michael Weinreich

Bart and Wendy Williams

Carolyn and Lawrence F. Witt

Eric and Shawna Xu

John Young

Ron Young and Heather Frazee

Linda Zarzecki and Dr. Liam Sullivan

Rachael Zhang

Mitchell A. Zoerhoff

Tribute and Memorial Gifts

In 2007, the following individuals and organizations

made a tribute or memorial gift in honor

of a family member, friend, or colleague with

a gift to Van Andel Institute. In recognition of

their thoughtfulness, we express appreciation.

Tributes

Pauline Baer

William and Barbara Bradley

Kevin and Michelle Bassett

Jean Bassett

Bill and Barbara Bradley

James H. and Sheral Bradley

Robert Cope

Holly Jacoby

Tessa Grabinski

Jared E. and Linda J. Gieske

Andrew Koo

David and Gloria Haebich

Rex Renfrow & Family

Arnold D. and Ilene D. Dashoff

Reverend Merlyn Satrom

John and Cheryl Tully

Memorials

Alison “Awesome Ali” Aardema

Eric E. Jones

James Bamborough

Florence Freeman

Mary Bek

Applied Imaging

Mary Benson

Steven and Teri B. Olson

Philip Bettendorf

William and Bernadette Motiska

Fred Birkeland

Jean Bassett

Jean Boomers

Jacqueline Bradley

Kevin and Kelly Chopp

Don and Doris DeGood

Michael B. and Renae D. Donahey

Lynn and Zell Gill

Richard J. and Lillian Havenga

Norman and Valerie L. Knapp

Robin and Yvonne Mancuso

Bud and Jane Miller

Jerry and Kathy Shear

A. Clare and Karen Silva

Suzanne J. Buche

Charles J. and Nancy J. Poquette

David J. and Amy R. Poquette

Peter Bylsma

Carol Bylsma

Scott Carlson

Nancy L. Carlson

Norma Coryell

Steven G. and Marguerite H. Baker

Stephen F. and Michelle Card

Ken and Norma Coryell

James and Cynthia Cotter

Howard T. Courtnay

Charlie and Linda Cusack

Scott and Linda A. Nash

David Quigley

Gregory and Tina Wolbers

Kathrine Crane

Carl and Anne Forslund

Courtney Dahlen

Lyle R. and Jacqueline J. Irish

Ann Damuth

Mary K. Redman

Frances Davidson

Yvonne M. Burns

Lyle R. and Jacqueline J. Irish

Gladys Davis

Sandra Ames

Jay DeBoe

Michael J. DeBoe

Carson Donley

Elizabeth A. Donley

Lisa Fair

Steven and Teri B. Olson

Marianne Fishback

Maryanna Johnson

Bill Fodren

Margaret H. Fondren

Emery Freeman

Joseph G. Popiel

Jean Frick

Allan C. and Barbara J. Lowe

John Fry

Julia B. Fry

Margaret Mary Gorski

Joanne Hunefeld

Robert Haight

Robin Shelley

Van Andel Institute


Mary “Tab” Hay

Jerry and Shirley Sherman

Christian Helmus, MD

Dan and Ann Marie Van Eerden

Jim Hickey

Catherine Amodeo

Larry W. Howe

Larry L. and Ginger Howe

Gordon J. and Jeanine Reeder

Larry Jersey

Lyle R. and Jacqueline J. Irish

Isabelle Johnson

Lyle R. and Jacqueline J. Irish

Melanie Keith

Lyle R. and Jacqueline J. Irish

Pastor Al Keller

Lyle R. and Jacqueline J. Irish

Marie King

Casey and Violet Wondergem

Tim and Kris Wondergem

Lyle Kinney

Craig and Deb Kinney

Lynn Konwinski

Ron and Joann Champion

Ronald and Cindi J. Czarnecki

Lisa Freybler

Kent Beverage Company Inc.

Bernadine Kozal

Diane Kozal

James D. Kozal

Lorraine Lavigne

Philip and Denise J. Overway

Kathryn Teesdale

Dr. Han Mo Koo

Carol Bylsma

John and Lydia Tobian

James M. Kozal

James D. Kozal

Angeline Landeis

Lyle R. and Jacqueline J. Irish

David B. Linn

AD Bos Vending Services

James W. Logie

John H. and Susan Logie

Peter & Joan Secchia

“What a time this is for Grand Rapids...new and improved medical facilities, a

new medical school, a focus on life sciences...and right at the heart of all of this

is Van Andel Institute. The city is experiencing a complete transformation.”

Jerry Matecun

Sally Matecun

Judith Mary McKenney

Ward J. and Shirley McKenney

Nicholas Mihos

Richard and Mary MacKeigan

Terry Moran

James and Joy DeBoer

John Mulder

Edwin J. and Dolores Nawrocki

Charles Edmund O’Keefe

Ruth O’Keefe

Carol Otto

Pamela Luetkemeyer

Ronald Pawloski

James E. and Francene M. Angers

Don and Lin Beenen

John and Jodie Formolo

Terri G. Gorton

JB2 Enterprises

Judith L. Kessel

Donald M. and Monica M. Kimball

Dolores Malec

Nicholas Malec

Claude and Gay M. Nauta

Charles and Suzanne Neureuther

Thomas W. and Jane A. Norton

Richard and Kathleen A. Noskey

Donald and Patricia Patterson

Robert and Karen S. Pearson

Louis G. and Terry K. Smith

Dick and Shirley Tedford

Bruce and Angela Towne

Michael Warber

Western Michigan Pediatrics Cardiology Associates, PC

John O. Plummer, Jr.

Lynn L. Plummer

Dwight Reed

Dwight Reed Memorial Golf Outing Participants

Ann Roffol

Vincent A. and Mary M. Ackerman

David L. Rossi

Anne Rossi

Stella Rovine

Richard and Mary MacKeigan

Kevin Ryskamp

Tom and Jean Almy

Guy S. Bailey

John, Evie, and Tommie Barfuss

Stephen and Michelle Doyle

John F. and Teresa A. Elliott

Helen K. Jansen

Kari A. LaPlaunt

Joby and Amanda Lewis

Scott and Nancy Liversedge

George Manus

Marina Shores Association

Jack W. and Delores Marks

John and Nancy K. Markward

Cynthia L. Martin

Joe and Darla McAlister

Brian and Susan Mooney

David, Kristen, Grayson, Beck and Alec Norris

Michael, Kristina, and Aidan O’Meara

Les and Barb Parker

Steve and Molly Parker

Steve and Ruth Pate

Sue Anne Renken

William, Kathryn, Lauren and Kate Ryan

Denise Ryskamp

Fredric E. Ryskamp

Jack and Dorothy Ryskamp

Christine Serne

Dan and Susan Serne

James A. and Eleanor L. Serne

Jeanne C. Serne

Michael S. Serne

Mike and Joann Serne

Patrick A. and June H. Serne

Jim and Kris Van Heule

Brian and Kim Whitson

Whitson Insulation Co. of Grand Rapids Inc.

Joan Wolverton

Ruth Ann Scripps

David and Debbie Keenan

Alan and Wendy Yamaoka

Jean Sheetz

Sandra Ames

Jo Smith

Betty Jane Forray

Linda C. Jennings

Joseph W. and Mildred Konrath

Betty J. Laroux

John W. and Sharon Matthews

Passaro & Kahne Law Office, PLLC

Robert and Brenda Stineman

Mike and Bev Vantieghrem

Sandra K. Warren

Pauline M. Stark

Sharry A. Fearon-Beatty

William L. and Barbara Parker

John and Mary Sheets

Richard and Pauline Stark Estate

Pamela A. Stark and Robert Weatherford

William Swaney

Mary M. Grigware

Keith N. and Sheryl S. Stewart

Russel P. and Jean Swaney

Thomas C. and Susan Swaney

Bill Terpstra

Sallie and David Brinks

Betty Van Andel

Arie E. and Jane Vandermale

Jay Van Andel

William and Bernadette Motiska

Nancy Van Andel

Stuart S. and Nelleke Vander Heide

Rita (Kober) Veltkamp

Deborah Kober

Johan Visser

Johan’s TriFest Participants

Kenneth Welsher

George Bischoff

R.K. and Char Fecho

Richard Kraklau

Karen Kuiper

Kaye LaVee Swanson

Gloria Mance

James and Elizabeth Mandarino

Louise Mueller

Irene Ott

Ron Ott

Caroline Patzer

Ronald and Mary Patzer

Gerald and Donna Pechtel

Angela Rambo

Lynn Vanpelt

Dee Wall

J.L. Wentland

Shirley Wohler

Katherine E. Whalen

Steve and Julie Miller

Stan Wietrecki

Sandra Ames

Mary Lois Wilke

Sandra Ames

Ora Zacharias

Brandt D. and Sharon M. Driscoll

Ric and Lisa Loyd

To make changes to how your name(s), or

your company’s name, is listed in future

publications, please call 616-234-5681.

To VAI’s many anonymous donors, we extend our quiet thanks.

VAI Donor

Recognition

www.vai.org

45


Organizational Structure

These lists reflect active participants as of December 31, 2007.

▲ Deceased (prior to January 1, 2008)

Van Andel Institute

Board of Trustees

VAI Board of Trustees

David Van Andel

Chairman and Chief Executive Officer, Van Andel Institute

Board of

Scientific Advisors

Van Andel Research Institute

Board of Trustees

Chief Executive Officer

Van Andel Education Institute

Board of Trustees

Ralph Hauenstein

President, Hauenstein Enterprises

Peter Cook

Chairman, Cook Holdings

John Kennedy

President and Chief Executive Officer, Autocam Corporation

David Van Andel

VAI Graduate School

Board of Directors

VAEI Council

Van Andel Research Institute

Director

Deputy Directors

Director of

Research

Administration

Basic Science

George Vande Woude, Ph.D.

Special Programs

Chief Administrative Officer

and General Counsel

Steven R. Heacock

VP Communications

and Development

Joseph P. Gavan

Van Andel Education Institute

Council

Van Andel Education Institute

Director

Gordon Van Harn, Ph.D.

Chief Financial Officer

R. Jack Frick

Vernon J. Ehlers, Ph.D.

United States Representative, former Professor of Physics and

former Chairman of Physics Department, Calvin College

G. Christian Jerenstedt, Ph.D.

Professor of Psychological and Brain Sciences and Director of

the Center for Educational Outcomes, Dartmouth College

P. Douglas Kindschi, Ph.D.

Interim President and CEO, Grand Rapids Medical Education

and Research Center and Professor of Mathematics and

former Dean of Science and Mathematics,

Grand Valley State University

Cornelius Plantinga, Jr., Ph.D.

Professor of Systematic Theology and President,

Calvin Theological Seminary

Carol Van Andel

Bachelor of Arts in Business, Hope College,

and Community Volunteer

Yvonne H. Van Ee, Ph.D.

Professor of Education and Early Childhood Program Advisor,

Calvin College

Van Andel Institute


VAI Board and Council Members

VARI Board of Trustees

David Van Andel

Chairman and Chief Executive Officer,

Van Andel Institute

Fritz Rottman, Ph.D.

Emeritus Professor and Chairman of

Molecular Biology and Microbiology,

Case Western University

Board of Scientific Advisors

James Wyngaarden, M.D.

Former Professor and Chairman of the

Department of Medicine at Duke University

School of Medicine, former Director of the

National Institutes of Health

VAEI Board of Trustees

David Van Andel

Chairman and Chief Executive Officer,

Van Andel Institute

Gordon L. Van Harn, Ph.D.

Director of VAEI, former Professor of Biology

and Provost at Calvin College

Hope on the Hill Board of Governors

Gordon Van Wylen, Ph.D.

Former President of Hope College,

former Dean of the Engineering School

at University of Michigan

Donald W. Maine

Former President of Davenport University

Michael S. Brown, M.D.

W. A. (Monty) Moncrief Distinguished Chair

in Cholesterol and Arteriosclerosis Research;

Regental Professor; Paul J. Thomas Chair in

Medicine, University of Texas Southwestern

Medical Center - Dallas

Richard Axel, M.D.

Professor of Neurosciences, Columbia

University

VAI Graduate School Board of Directors

James N. Boelkins, Ph.D.

Provost, Hope College

James B. Fahner, M.D.

Chief of Hematology/Oncology,

Helen DeVos Children’s Hospital

Nita J. Maihle, Ph.D.

Professor of Obstetrics/Gynecology and

Reproductive Sciences, Yale School of Medicine

and Chair of Women in Cancer Research

Council, American Association for Cancer

Research

Joseph L. Goldstein, M.D.

Chairman of the Department of Molecular

Genetics, University of Texas Southwestern

Medical Center - Dallas

Tony Hunter, Ph.D.

Professor, Salk Institute; American Cancer

Society Research Professor

Phillip A. Sharp, Ph.D.

Institute Professor of Biology, Massachusetts

Institute of Technology

Fritz M. Rottman, Ph.D.

Emeritus Professor and Chairman of Molecular

Biology and Microbiology, Case Western

Reserve University and Member of Van Andel

Research Institute Board of Trustees

John L. Wang, Ph.D.

Professor of Biochemistry, Michigan State

University

Gordon L. Van Harn, Ph.D.

Director of Van Andel Education Institute and

Emeritus Provost and Professor of Biology,

Calvin College

President Jimmy Carter

Honorary Chair

William and Sandi Nicholson

Honorary Vice Chair

L. William and Sarah Seidman

Honorary Vice Chair

John and Marie Canepa

Chair

Martin and Sue Allen

James and Shirley Balk

Mark Bartlett

John and Nancy Batts

James and Donna Brooks

James and Martha Bultman

Gaylen and Susan Byker

Peter C. and Pat Cook

William and Janice Currie

David and Karen Custer

Daniel and Pamella DeVos

Ted and Barb Etheridge

David and Judy Frey

R. Jack and Mary Frick

Joseph and Susan Gavan

Dan and Lou Ann Gaydou

Gary Granger

Ralph and Grace▲ Hauenstein

Steven and Brenda Heacock

David and Joyce Hecht

John and Gwen Hibbard

Dirk and Victoria Hoffius

Earl and Donnalee Holton

Robert and Judith Hooker

Allen and Helen Hunting

Earle and Kyle Irwin

Mike and Sue Jandernoa

Sidney Jansma, Jr.

Hamilton and Dorothy Jordan

John and Nancy Kennedy

Wilbur and Sharon Lettinga

Ray and Nancy Loeschner

Tim and Kim Long

Donald and Kathleen Maine

Fred and Lena Meijer

Hendrik and Liesel Meijer

Mark and Mary Beth Meijer

Jack H. Miller

Mark and Elizabeth Murray

Donald and Ann Parfet

Mark and Dianne Peters

Dale and Sonja Robertson

Alan and Margaret Ryan

Peter and Joan Secchia

Budge and Marilyn Sherwood

Brent and Diane Slay

Russel and Jean Swaney

Marilyn Titche

David and Carol Van Andel

Michael and Michelle Van Dyke

Gordon and Mary Van Harn

Gordon and Margaret Van Wylen

George and Dot Vande Woude

Stuart and Nelleke Vander Heide

Theodore and Joan Vanderveen

Casey and Violet Wondergem

VAI Board

and Council Members

www.vai.org

47


Celebration of Hope

Over seven years, Van Andel Institute’s annual gala event,

Celebration of Hope, has been the venue for several

significant unveilings and announcements, starting with the

VAI grand opening at the first event in 2000. In 2001, VAI Chairman

and CEO David Van Andel announced that the facility’s grand hall

would be named the “Cook-Hauenstein Hall” in honor of founding

trustees Peter C. Cook and Ralph W. Hauenstein. VAI dedicated “Life,”

a 14-foot, glass sculpture created by world-famous artist Dale Chihuly,

in 2005. Commissioned by VAI founder Jay Van Andel to memorialize

his wife and cofounder, Betty Van Andel, the work still spirals from the

ceiling of the VAI lobby, reminiscent of the DNA double helix. In 2006,

David Van Andel unveiled a plaque to hang in the Institute honoring Dr.

Christian Helmus, a physician and member of the Van Andel Research

Institute Board of Trustees who died in 2006 after a long battle with

liver cancer.

At the most recent Celebration of Hope in 2007, Dr. Randy Hillard,

associate provost for Human Health Affairs at the Michigan State

University College of Human Medicine, announced the creation of

the David Van Andel Life Sciences Achievement Award. The award

will be bestowed annually upon a scientist or clinician who has made

significant discoveries in translational research, an entrepreneur who

makes significant progress in commercializing a life science discovery,

an advocate for life sciences research and commercialization, or

a philanthropist whose contributions have enhanced translational

medicine or life sciences research.

< Top: Guests at the 2007 Celebration of Hope, Bottom left: Emmy awardwinning

comedian Dennis Miller entertains guests in 2006, Bottom right:

Dale Chihuly’s “Life” was unveiled at the 2005 Celebration of Hope

Van Andel Institute


See our award-winning commercials

and the rest of our video library

on the web at:

www.vai.org/news.aspx

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