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Figure Legends 20 JPET #193193 PiP Figure 1. Induction of hepatic aminoazo dye metabolism. In A, immature male rats were injected i.p. with 0.5 mg of 3-methylcholanthrene (3-MC) or corn oil (control vehicle) 24h before incubation of 3-methyl-4- monomethylaminoazobenzene (3-Me-MAB) with their liver homogenates for 12 min at 37°C, and 3-methyl-4-aminoazobenzene (3-Me-AB) was measured (Conney, 1954). In B, immature male mice were injected i.p. with 2 mg of 3- methylcholanthrene or corn oil (control vehicle) once a day for one week. The data are expressed as μg of 3-Me-AB formed by 30 mg of liver in 20 min [Brown et al, 1954]. In C, immature male rats were injected i.p. with 1 mg of 3-MC or corn oil (control vehicle), and the N-demethylation of 3-Me-MAB and reduction of 4- dimethylaminoazobenzene (DAB)was measured at different times after the injection [Conney et al, 1956]. Figure 2. Induction of hepatic benzo[a]pyrene (BP) and zoxazolamine metabolism. In A, immature male rats were injected i.p. with 0.1 or 1.0 mg of BP or corn oil (control vehicle) and sacrificed at various times after the injection [Conney et al, 1957]. In B, the rats were injected i.p. with 1 mg of BP or corn oil (control vehicle) and sacrificed 24 hr later [Conney et al, 1960]. In C, the rats were injected i.p. with 1 mg of BP or corn oil (control vehicle), and 24 hr later they were injected i.p. with zoxazolamine (100 mg/kg) and total body metabolism of zoxazolamine was measured [Conney et al, 1960].
21 JPET #193193 PiP Figure 3. Effect of cigarette smoking and ingestion of charcoal-broiled beef on plasma levels of phenacetin in humans. In A, smokers and nonsmokers were given a 900 mg oral dose of phenacetin. Each value is the mean ± S.E. from 9 subjects [Pantuck et al, 1972; Pantuck et al, 1974a]. In B, a 900 mg oral dose of phenacetin was administered after a control diet for 7 days, a charcoal-broiled beef diet for 4 days and a control diet for the next 7 days. Each value is the mean ± S.E. from 9 subjects [Conney et al, 1976]. Figure 4. Plasma levels of nortriptyline in patients receiving 150mg daily (Asberg, 1974).
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