BAŞSAĞLIĞI / CONDOLENCESÜyelerimizden,İstanbul Üniversitesi İstanbul Tıp FakültesiHematoloji Bilim Dalı emekli öğretim üyesiProf. Dr. Melih Aktan’ınzamansız vefatı hepimizi çok üzdü.Değerli hocamızın ailesine, yakınlarına ve tüm hematolojicamiasına başsağlığı dileriz.The untimely loss of our member,a retired faculty member of İstanbul Faculty of Medicine,Department of Hematology,Prof. Dr. Melih Aktan,has made us all very sad.We extend our condolences to our esteemed professor’s family,his relatives, and the entire hematology community.
Kavaklı K. et al: Ultrasound and Monitoring for HemophiliaRESEARCH ARTICLEDOI: 10.4274/tjh.galenos.2021.2020.0717Turk J Hematol 2021;38:101-110Impact of the HEAD-US Scoring System for Observing theProtective Effect of Prophylaxis in Hemophilia Patients:A Prospective, Multicenter, Observational StudyHemofili Hastalarında Profilaksinin Koruyucu Etkisinin Gözlenmesinde HEAD-US SkorlamaSisteminin Önemi: Prospektif, Çok Merkezli ve Gözlemsel Bir ÇalışmaKaan Kavaklı 1 , Süha Süreyya Özbek 2 , Ali Bülent Antmen 3 , Fahri Şahin 4 , Şevkiye Selin Aytaç 5 , Alphan Küpesiz 6 ,Bülent Zülfikar 7 , Mehmet Sönmez 8 , Ümran Çalışkan 9 , Can Balkan 1 , Tuğana Akbaş 10 , Taner Arpacı 10 , İpek Tamsel 2 ,Turgut Seber 11 , Berna Oğuz 11 , Can Çevikol 12 , Mesut Bulakçı 7 , Polat Koşucu 13 , Demet Aydoğdu 14 , İlgen Şaşmaz 3 ,Gülen Tüysüz 6 , Başak Koç 7 , Hüseyin Tokgöz 9 , Zuhal Mehrekula 4 , Burcu Özkan 151Ege University Children’s Hospital, Clinic of Children’s Health and Diseases, Division of Pediatric Hematology, İzmir, Turkey2Ege University Medical Faculty Hospital, Clinic of Radiology, Division of Hematology, İzmir, Turkey3Acıbadem Adana Hospital, Clinic of Pediatric Hematology, Adana, Turkey4Ege University Medical Faculty Hospital, Clinic of Internal Diseases, Division of Hematology, İzmir, Turkey5Hacettepe University Faculty of Medicine, Department of Children’s Health and Diseases, Division of Pediatric Hematology, Ankara, Turkey6Akdeniz University Hospital, Clinic of Children’s Health and Diseases, Antalya, Turkey7İstanbul University Hemophilia Comprehensive Care Center, İstanbul, Turkey8Karadeniz Technical University Medical Faculty Farabi Hospital, Clinic of Internal Diseases, Division of Hematology, Trabzon, Turkey9Necmettin Erbakan University Meram Medical Faculty Hospital, Department of Children’s Health and Diseases, Konya, Turkey10Acıbadem Adana Hospital, Clinic of Radiology, Adana, Turkey11Hacettepe University Faculty of Medicine, Department of Radiology, Ankara, Turkey12Akdeniz University Hospital, Clinic of Radiology, Antalya, Turkey13Karadeniz Technical University Medical Faculty Farabi Hospital, Clinic of Radiology, Trabzon, Turkey14Necmettin Erbakan University Meram Medical Faculty Hospital, Clinic of Radiology, Konya, Turkey15Pfizer Pharmaceuticals, Rare Disease Department, İstanbul, TurkeyAbstractObjective: This study aimed to observe the preventive effect ofprophylactic treatment on joint health in people with hemophilia (PwH)and to investigate the importance of integration of ultrasonographicexamination into clinical and radiological evaluation of the joints.Materials and Methods: This national, multicenter, prospective,observational study included male patients aged ≥6 years with thediagnosis of moderate or severe hemophilia A or B from 8 centersacross Turkey between January 2017 and March 2019. Patients werefollowed for 1 year with 5 visits (baseline and 3 rd , 6 th , 9 th , and 12 thmonth visits). The Hemophilia Joint Health Score (HJHS) was used forphysical examination of joints, the Pettersson scoring system was usedfor radiological assessment, point-of-care (POC) ultrasonography wasused for bilateral examinations of joints, and the Hemophilia EarlyArthropathy Detection with Ultrasound (HEAD-US) score was used forevaluation of ultrasonography results.ÖzAmaç: Bu çalışmada hemofili hastalarında profilaksinin eklem sağlığıüzerindeki koruyucu etkisini gözlemlemek ve eklemlerin klinik veultrasonografik olarak değerlendirilmesinin öneminin araştırılmasıamaçlandı.Gereç ve Yöntemler: Ulusal, çok merkezli, prospektif ve gözlemsel olanaraştırma Ocak 2017 - Mart 2019 arasında 8 ayrı merkezde takip edilenerkek ve 6 yaşından büyük orta seviyede veya ağır hemofili-A ve hemofili-Bhastalarını kapsıyordu. Hastalar 1 yıllık takip sırasında toplam 5 ayrı vizitte(başlangıç, 3. ay, 6. ay, 9. ay ve 12. ay) değerlendirildi. Hemofili EklemSağlığı Skoru (HJHS) eklemlerin fiziksel bakısında kullanılırken Pettersonskorlama sistemi radyolojik bakı sırasında değerlendirildi. Ayrıca, hastabaşı ultrasonografisiyle bilateral eklem incelemeleri yapılarak HEAD-USskorlama yöntemiyle eklem skorları belirlendi.©Copyright 2021 by Turkish Society of HematologyTurkish Journal of Hematology, Published by Galenos Publishing HouseAddress for Correspondence/Yazışma Adresi: Kaan Kavaklı, M.D., Ege University Children’s Hospital,Clinic of Children’s Health and Diseases, Division of Pediatric Hematology, İzmir, TurkeyPhone : +90 542 432 87 38E-mail : kaan.kavakli61@gmail.com ORCID: orcid.org/0000-0003-1174-1958Received/Geliş tarihi: November 30, 2020Accepted/Kabul tarihi: January 26, 2021101
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