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Turk J Hematol 2017;34:356-381LETTERS TO THE EDITORReceiver Operating Characteristic Curve Analysis May be Helpfulto Study the Prognostic Value of miR-155 in B-Cell Non-HodgkinLymphomaİşlem Karakteristik Eğrisi Analizi B-Hücre Non-Hodgkin Lenfomada miR-155’in PrognostikDeğerini Çalışmada Yardımcı OlabilirLong SuThe First Hospital of Jilin University, Department of Hematology, Changchun, ChinaTo the Editor,Aberrant expression of microRNA (miR-155) has been reportedpreviously in several hematological malignancies [1,2,3,4].Recently, Bedewy et al. [5] published their excellent findingsin this journal. They reported that miR-155 expression wassignificantly upregulated in patients with B-cell non-Hodgkinlymphoma (NHL) compared with normal controls. In patientswith B-cell NHL, a high level of miR-155 expression wasassociated with the presence of B symptoms, involvement ofextranodal sites, and high Eastern Cooperative Oncology Groupscore. In patients with diffuse large B-cell lymphoma (DLBCL),high miR-155 levels were related to non-germinal B-cell-liketype and higher International Prognostic Index scores. HighmiR-155 expression was also associated with inferior event-freesurvival. Accordingly, the authors concluded that miRNA-155might be a potential biomarker of prognosis and monitoring inB-cell NHL, and especially that of the DLBCL type [5].Receiver operating characteristic (ROC) curve analysis is agraphical plot that illustrates the diagnostic ability of a binaryclassifier system as its discrimination threshold is varied.The best cutoff value can be calculated by ROC analysis forcontinuous variables to predict dichotomous variables with thebest sensitivity and specificity. In Bedewy et al.’s [5] study, thepatients were divided into high-expression and low-expressiongroups based on the median level of miR-155 relative expressionunits. I wonder if the median value of miR-155 expression levelin this study was the cutoff value with the best sensitivityand specificity between patients and normal controls by ROCanalysis. Similarly, in patients with B-cell NHL, whether thereis another cutoff value that is associated with clinical stage,treatment response, long-term outcomes, and so on remains tobe determined.Keywords: Non-Hodgkin lymphoma, miR-155, Prognostic valueAnahtar Sözcükler: Non-Hodgkin lenfoma, miR-155, PrognostikdeğerConflict of Interest: The authors of this paper have no conflictsof interest, including specific financial interests, relationships,and/or affiliations relevant to the subject matter or materialsincluded.References1. Jones K, Nourse JP, Keane C, Bhatnagar A, Gandhi MK. Plasma microRNA aredisease response biomarkers in classical Hodgkin lymphoma. Clin Cancer Res2014;20:253-264.2. Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, AlexanderM, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth WP, Rao DS, MilesRR, Round JL, Deininger MW, O’Connell RM. miR-155 promotes FLT3-ITDinducedmyeloproliferative disease through inhibition of the interferonresponse. Blood 2017;129:3074-3086.3. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC,Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, LuL, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, WeisenburgerDD, Armitage JO, Warnke R, Levy R, Wilson W, Grever MR, Byrd JC, BotsteinD, Brown PO, Staudt LM. Distinct types of diffuse large B-cell lymphomaidentified by gene expression profiling. Nature 2000;403:503-511.4. Marcucci G, Maharry KS, Metzeler KH, Volinia S, Wu YZ, Mrózek K, NicoletD, Kohlschmidt J, Whitman SP, Mendler JH, Schwind S, Becker H, EisfeldAK, Carroll AJ, Powell BL, Kolitz JE, Garzon R, Caligiuri MA, Stone RM,Bloomfield CD. Clinical role of microRNAs in cytogenetically normal acutemyeloid leukemia: miR-155 upregulation independently identifies high-riskpatients. J Clin Oncol 2013;31:2086-2093.5. Bedewy AML, Elmaghraby SM, Shehata AA, Kandil NS. Prognostic value ofmiRNA-155 expression in B-cell non-Hodgkin lymphoma. Turk J Hematol2017;34:207-212.Address for Correspondence/Yazışma Adresi: Long SU, M.D.,The First Hospital of Jilin University, Department of Hematology, Changchun, ChinaPhone : +86 0431 887 821 57E-mail : sulongjdyy@163.com ORCID-ID: orcid.org/0000-0002-5360-468XReceived/Geliş tarihi: August 09, 2017Accepted/Kabul tarihi: August 22, 2017DOI: 10.4274/tjh.2017.0297381
AUTHOR INDEX 201734 th Volume Index / 34. Cilt DiziniAUTHOR INDEX - YAZAR DİZİNİ 2017A. Emre Eşkazan................................. 233, 291Abdulkadir Ünsal......................................... 116Abdurrahman Kara........................................ 40Abraham Pouliakis......................................... 52Ageliki Tirogala............................................... 52Ahmad Antar................................................358Ahmed A. Shehata.......................................207Ahmed M. L. Bedewy..................................207Ahmet Emin Kürekçi..................................... 64Ahmet Koluman............................................. 93Ahmet Muzaffer Demir............................... 89Ahmet Pekoğlu............................................... 64Ahmet Uygun................................................359Ahu Senem Demiröz......................................81Aida Berenjian.............................................. 118Aidin Meshksar.............................................250Ajlan Tükün...................................................151Aleksandar Jankovic...................................268Alessandro Allegra.......................................184Alexandra Tsoka............................................. 52Ali Eser............................................................ 118Ali Fettah.......................................40, 183, 372Ali Şahin Küçükaslan..................................174Ali Ünal............................................................. 27Alişan Yıldıran...............................................345Ana Bulatovic...............................................268Ana Catarina Oliveira.................................372Ana K. Nuñez-Cortes..................................239Anastasia Livada............................................ 52Andaç Salman............................................... 118Andreia Lopes...............................................372Andrés A. Leon-Peña..................................239Anna J. Kopinska..........................................186Anna Koclega................................................186Anurag Gupta...............................................370Argyrios Tsantes............................................. 52Arie C. Van Der Spek...................................124Arzu Akyay..................................................... 114Arzu Ekici.......................................................264Ashutosh Kumar..........................................369Aslı Akın Belli...................................... 122, 192Aslı Korur....................................196, 280, 324Aspasia Argyrou............................................. 52Asude Kara........................................... 122, 192Aşkın Şen........................................................ 114Ayfer Gedük..................................................190Ayla Eker Sarıboyacı...................................213Aylin Okçu Heper.........................................194Aynur Küçükçongar Yavaş........................264Aysel Pekel....................................................... 64Ayşe Salihoğlu.................................... 233, 291Ayşegül Üner................................................... 34Aytekin Ünlü................................................... 64Azhar Sattar..................................................278Bahattin Tunç........................................40, 183Baohua Huang..............................................126Baoshan Liu...................................................200Barış Malbora................................................179Behnaz Valibeigi..........................................300Bengi Öztürk................................................... 16Bengü Nisa Akay..........................................194Berna Atabay................................................179Betül Orhaner...............................................264Betül Tavil........................................................ 40Beuy Joob..............................................101, 380Bin Wang........................................................200Buket Kosova................................................174Burcu Belen...................................................179Burcu Yazıcıoğlu..........................................143Burçin Tezcanlı Kaymaz.............................174Can Boğa...........................196, 270, 280, 324Carl Hsieh.......................................................328Caterina Musolino.......................................184Celalettin Üstün............................................. 16Celeste Bento................................................372Cengiz Bayram................................................ 40Cengiz Beyan................................................359Cengiz Ceylan...............................................197Cengizhan Açıkel........................................... 64Chen Fangping................................................10Cheng-Wei Chou.........................................159Chieh-lin Jerry Teng...................................159Chingiz Asadov.............................................258Chunhua Song..............................................366Çağatay Taşkapan........................................ 114Çağdaş Aktan................................................174Çağla Sarıtürk...............................................324Çetin Demir..................................................... 34Çiğdem Gereklioğlu.................196, 280, 324Çiğdem Seher Kasapkara...........................376Demet Aydın.................................................167Demet Çekdemir............................................ 27Deniz Kızmazoğlu.......................................... 46Deniz Yılmaz Karapınar..............................254Deniz Yücelten.............................................. 118Devrim Dündar.............................................340Dildar Bahar Genç.......................................109Dilek Gürlek Gökçebay...............................183Dimitra Agoritsa............................................. 52Dimitrios Maltezos........................................ 52Ebru Yılmaz Keskin......................................372Eda Ataseven................................................... 46Eda Güngörürler..........................................213Ekaterini Kontopanou.................................. 52Ekaterini Manaka........................................... 52Eldar Abdulalimov.......................................258Eleonora Lamantea.....................................376Elias Kyriakou.................................................. 52Elias Markopoulos......................................... 52Elif Azarsız.....................................................254Elif Gülsüm Ümit........................................... 89Elisavet Grouzi................................................ 52Elise Schapkaitz.............................................. 59Emel Özyürek................................................345Emin Kaya........................................................ 27Emin Sami Arısoy.........................................340Emine Begüm Gençer.................................314Emine Dağıstan............................................120Emine Zengin................................................340Emmanouil Lysikatos.................................... 52Emre Ali Acar................................................181Erdal Karaöz..................................................213Erdal Kurtoğlu.................................... 122, 192Erden Atilla........................................1, 16, 244Erkan Maytalman........................................280Esra T. Demirsoy...........................................190Fadıl Vardar...................................................254Fahri Şahin..............................................27, 174Fatih Demircioğlu........................................120Fatih Ezgü......................................................376Fatih Kandemir.............................................280Fatma Demir Yenigürbüz............................ 46Fatma Demirel................................................ 40Fatma Dilek Kaymakçı................................ 118Fehmi Hindilerden......................................... 72Ferda Perçin...................................................143Ferit Avcu......................................................... 64Fevzi Fırat Yalnız..........................................233Feyza Bayrakdar Çağlayan........................ 116Figen Kuloğlu.................................................. 89Filiz Vural.......................................................... 27Funda Ceran..................................................226Funda Şimşek................................................167Füsun Özdemirkıran...................................... 27George Karam...............................................358Gökhan Güngör............................................356Gökhan Özgür...............................................359Gönül Oğur....................................................345Grzegorz Helbig...........................................186Guifang Ouyang...........................................362Guillermo J. Ruiz-Argüelles......................239Guillermo J. Ruiz-Delgado........................239Gunay Aliyeva...............................................258Gül Nihal Özdemir......................................... 99Gülay Erman..................................................213Güldane Seval...............................................137Gülsüm Çağlıyan............................................ 27Gülsüm Özet..................................................226Gülşen Bolat.................................................... 16Günhan Gürman............................................ 16Güray Saydam.......................................27, 174Gürcan Dikme................................................. 99Gürsel Güneş.................................................103Habip Gedik...................................................167Hakan Erdoğan.............................................264Hakan Göker.................................................103Hakan Hanımoğlu........................................ 113Hakan Özdoğu.................196, 270, 280, 324Haldun Öniz...................................................179Hale Ören......................................................... 46Halil Gürhan Karabulut..............................151
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TURKISH JOURNAL OF HEMATOLOGYINSTRU
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352 Giant Intracranial Solitary Pla
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