National Cancer Institute - NCI Division of Cancer Treatment and ...

significance of Akt activation in NSCLC
tumors. Collaboration of Drs. Joanna
Shih, BRB, Jin Jen, CCR Laboratory of
Population Genetics, and Phillip A.
Dennis, CCR Cancer Therapeutics Branch.
■ Ingenuity network assisted transcription
profiling: identification of a new pharmacological
mechanism for MK886.
Collaboration of Drs. Shih, BRB, and
Anatoly L. Mayburd, CCR Cell and
Cancer Biology Branch.
■ Desmoglein 3 as a prognostic indicator
in lung cancer. Collaborators are
Drs. Shih, BRB, and Jen.
■ Cross-species comparisons of mouse
mammary tumor models and human
breast cancer by expression profiling:
identification of luminal and basal
phenotypes and a conserved gene
signature discriminating estrogenreceptor-positive
from estrogenreceptor-negative
tumors. Collaboration
of Drs. Shih and Jeff Green, CCR
Laboratory of Cell Regulation and
Carcinogenesis.
■ Histological staining method preparatory
to laser capture microdissection
significantly affects detection of mRNAs
in microarray hybridization. Collaboration
of Drs. Shih and Frederic Mushinski,
CCR Laboratory of Genetics.
■ Identifying the sequential alterations
of the genome, transcriptome, and
proteome that define the transformation
of normal colon epithelium and
the progression from adenomas to
invasive disease. Collaboration of
Drs. Lisa McShane and Ed Korn, BRB,
with Thomas Ried and others of
the CCR Cancer Genomics Section
of the Genetics Branch.
■ Effectiveness of gene expression profiling
for response prediction of rectal
adenocarcinomas in preoperative
chemoradiotherapy. Collaboration of
Drs. Sudhir Varma and Richard Simon,
BRB, with Ried and his colleagues.
■ Selective utilization of the Wnt/
b-catenin signaling pathway and
aneuploidy-dependent massive
deregulation of the cellular transcriptome
in human rectal carcinomas.
Collaboration of Drs. Varma and Simon,
BRB, with Ried and colleagues.
Dr. Thomas Ried, CCR Genetics Branch.
Network mapping of genes involved in rectal tumorigenesis. Shades of red
indicate genes with five-fold or greater expression in the tumors; shades of
green indicate genes with a more than five-fold decrease in expression in
the tumors relative to the normal rectal mucosa.
B I O M E T R I C R E S E A R C H B R A N C H ■ 15