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XTL BIOPHARMACEUTICALS LTD.

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General and Administrative Expenses. General and administrative expenses increased by $119,000 to $5,576,000 for the year ended<br />

December 31, 2006, as compared to expenses of $5,457,000 for the year ended December 31, 2005. The increase in general and administrative<br />

expenses was due primarily to increased expenses associated with the hiring of our Chief Executive Officer in 2006 and with being a US public<br />

company, offset by a decrease of $649,000 in non-cash compensation costs, related to option grants. In 2005 a market capitalization-based milestone,<br />

associated with certain grants made to our Chairman and to one of our non-executive directors in 2005 (see “Item 6. Directors, Senior Management and<br />

Employees - Employment Agreements”) was achieved; in 2006, no such milestone was achieved, resulting in a decrease in non-cash compensation<br />

expense in 2006 as compared to 2005.<br />

Business Development Costs. Business development costs increased by approximately $414,000 to $641,000 for the year ended December 31,<br />

2006, as compared to expenses of $227,000 for the year ended December 31, 2005. The increase in business developments costs was due primarily to<br />

increased expenses associated with our acquisition and in-licensing program, which included legal and due diligence expenses associated with the<br />

recent in-licensing of Bicifadine.<br />

Financial and Other Income. Financial and other income for the year ended December 31, 2006, increased by $698,000 to $1,141,000, as<br />

compared to financial income of $443,000 for the year ended December 31, 2005. The increase in financial and other income was due primarily to a<br />

higher level of invested funds due to the completion of the private placement that closed in May 2006, as well as due to the general increase in shortterm<br />

market interest rates when compared to the comparable period last year.<br />

Income Taxes. Income tax expense increased by $149,000 to $227,000 for the year ended December 31, 2006, as compared to expenses of<br />

$78,000 for year ended December 31, 2005. Our income tax expense is attributable to taxable income from the continuing operations of our subsidiary<br />

in the US. This income is eliminated upon consolidation of our financial statements.<br />

2005 Restructuring<br />

In 2005, we implemented a restructuring plan designed to focus our resources on the development of our then lead programs, which we refer<br />

to as the 2005 Restructuring, with the goal of moving those programs through to clinical proof of concept. The 2005 Restructuring included a 32<br />

person reduction in our workforce, 31 of whom were in research and development and one of whom was in general and administrative. As part of the<br />

2005 Restructuring, we took a charge in 2005 of $168,000, relating to employee dismissal costs, $163,000 of which was included in research and<br />

development costs and $5,000 of which was included in general and administrative expenses. The 2005 Restructuring was completed in early 2006,<br />

with the $168,000 of dismissal costs paid as of December 31, 2006. In December 2005, as a result of the 2005 Restructuring, and in accordance with<br />

the provisions of SFAS No. 144, “Accounting for the Impairment or Disposal of Long-Lived Assets,” or SFAS 144, we reviewed the carrying value of<br />

certain lab equipment assets, and recorded an impairment charge in research and development costs in an amount of $26,000 in 2005.<br />

Critical Accounting Policies<br />

The discussion and analysis of our financial condition and results of operations is based upon our consolidated financial statements, which<br />

have been prepared in accordance with US GAAP. The preparation of these financial statements requires us to make estimates and judgments that<br />

affect the reported amount of assets and liabilities and related disclosure of contingent assets and liabilities at the date of our financial statements and<br />

the reported amounts of revenues and expenses during the applicable period. Actual results may differ from these estimates under different assumptions<br />

or conditions.<br />

We define critical accounting policies as those that are reflective of significant judgments and uncertainties and which may potentially result<br />

in materially different results under different assumptions and conditions. In applying these critical accounting policies, our management uses its<br />

judgment to determine the appropriate assumptions to be used in making certain estimates. These estimates are subject to an inherent degree of<br />

uncertainty. Our critical accounting policies include the following:<br />

Stock Compensation. We have granted options to employees, directors and consultants, as well as warrants to other third parties. SFAS No.<br />

123R “Share - Based Payment,” or SFAS 123R, addresses the accounting for share-based payment transactions in which a company obtains employee<br />

services in exchange for (a) equity instruments of a company or (b) liabilities that are based on the fair value of a company’s equity instruments or that<br />

may be settled by the issuance of such equity instruments.<br />

The fair value of stock options granted with service conditions was determined using the Black-Scholes valuation model. Such value is<br />

recognized as an expense over the service period, net of estimated forfeitures, using the straight-line method under SFAS 123R. The fair value of stock<br />

options granted with market conditions was determined using a Monte Carlo Simulation method. Such value is recognized as an expense using the<br />

accelerated method under SFAS 123R.<br />

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