nanosymposium - Society for Neuroscience

9:15 313.4 Regulation of spinal sensory afferent bifurcation by
Slit and CNP signaling. L. MA. USC.
9:35 313.5 Dynamics and molecular control of axon branching
in vivo. M. C. HALLORAN. Univ. Wisconsin.
9:55 313.6 In vivo imaging of axonal dynamics in the
mammalian neocortex. V. DE PAOLA. Imperial Col. London.
10:15 313.7 Optimal axonal and dendritic branching strategies
during the development of retinotopic maps. D. TSIGANKOV.
Max-Planck-Institute for Dynamics and Self-Organization.
10:35 313.8 Closing Remarks.
MINISYMPOSIUM San Diego Convention Center
314. • Towards the Second Generation of Optogenetic
Tools CME
Mon. 8:30 AM - 11:00 AM — Room 29D
Chair: T. KNOPFEL
Co-Chair: E. BOYDEN
The optogenetic toolbox involves genetically encoded
actuators and reporters, proteins that allow using light
to control or to monitor molecular processes in neural
systems. Optical methods enable fast and spatially well
resolved experimental manipulations and measurements.
A first generation of genetically-encoded calcium reporters,
fluorescent proteins, and neural activators has already had
great impact on neuroscience; a second generation of voltage
reporters, neural silencers, and extended fluorescent proteins
bears great promise to continue this revolution. Speakers
will be particularly encouraged to highlight limitations of the
presently available optogenic tools and discuss where the
technologies are headed in the future.
8:30 314.1 Introduction.
8:35 314.2 • Novel optical neural control tools: towards enabling
integrative analysis of neural systems. E. S. BOYDEN. MIT.
8:55 314.3 New generation of voltage sensitive fluorescent
proteins for in vivo imaging of neuronal circuit dynamics. T.
KNOPFEL. RIKEN Brain Sci. Inst.
9:15 314.4 Choosing the right channelrhodopsin variant for your
neuroscientific experiment. J. Y. LIN. UCSD.
9:35 314.5 Optogenetic control of signal transduction via a lightgated
protein-protein interaction. A. LEVSKAYA. UCSF.
9:55 314.6 Red shifted fluorescent proteins for in vivo imaging.
M. Z. LIN. UCSD.
10:15 314.7 Imaging neural activity with genetically encoded
calcium indicators. L. TIAN. HHMI Janelia Res. Campus.
10:35 314.8 Closing Remarks.
MINISYMPOSIUM San Diego Convention Center
315. • Dendritic Spine Dysfunction in Mental Disorders CME
Mon. 8:30 AM - 11:00 AM — Room 30E
Chair: P. PENZES
Co-Chair: D. A. LEWIS
Speakers will discuss recent research and conceptual
advances regarding the dysregulation of structural plasticity
at spiny synapses in mental disorders. We will focus on
schizophrenia and autism, where a role for abnormal synaptic
plasticity and connectivity is well documented. Talks will
explore cellular neuropathological alterations and their
potential genetic and mechanistic underpinnings, which
may involve the disruption of signaling by small GTPases,
neuregulin, DISC1, kalirin-7, neuroligin, and Epac2.
8:30 315.1 Introduction.
8:35 315.2 Transgenic expression of Neuregulin 1, type IV
regulates synaptic maturation in vitro and impairs cortical
function in mice. A. J. LAW. NIMH, NIH.
8:55 315.3 • Molecular mechanisms of lamina-specific dendritic
spine alterations in in schizophrenia. D. A. LEWIS. Univ. of
Pittsburgh.
9:15 315.4 Disrupted in synapse by Disrupted-in-Schizophrenia
1 (DISC1): dendritic spine pathogenesis in schizophrenia. A.
HAYASHI. RIKEN Brain Sci. Inst.
9:35 315.5 Synaptic spine distribution and morphology on
cortical projection neurons in autism spectrum disorders. J. J.
HUTSLER. Univ. of Nevada.
9:55 315.6 Aberrant neuroligin function in autism. C. ZHANG.
Stanford Univ. Sch. of Med.
10:15 315.7 Regulation of dendritic spine dynamics by autismassociated
synaptic molecules. P. PENZES. Nothwestern
Univ. Feinberg Sch. Med.
10:35 315.8 Closing Remarks.
DAVID KOPf LECTURE ON NEUROEThICS San Diego
Convention Center
316. The Neuroscience Revolution and Society
Mon. 10:00 AM - 11:10 AM — Ballroom 20
Speaker: H. T. GREELY, Stanford Univ.
Support contributed by David Kopf Instruments
The onrushing revolution in neuroscience will change not
just science and medicine, but all aspects of human society.
This lecture will outline six different ways neuroscience
will affect society, through findings that concern prediction,
mindreading, responsibility, consciousness, treatment for
disfavored behaviors, and cognitive enhancement. It will
end by suggesting ways in which neuroscience might more
deeply affect our understandings of our fellow humans - and
of ourselves.
2 | Society for Neuroscience • Indicated a real or perceived conflict of interest, see page 157 for details.
� Indicates a high school or undergraduate student presenter.