nanosymposium - Society for Neuroscience

NANOSYMPOSIUM
8:15 320.2 Elucidation of amyloid β-protein oligomerization
pathways in the absence and presence of toxicity inhibitors:
A multiscale computational study. B. URBANC*; B. BARZ; M.
BETNEL; L. CRUZ; G. BITAN; D. B. TEPLOW. Drexel Univ.,
Boston Univ., David Geffen Sch. of Med. at UCLA.
8:30 320.3 Amyloid beta oligomers decrease hippocampal
network activity: Involvement of the Integrin/FAK/Fyn/GSK3
signaling pathway. H. BALLEZA-TAPIA; A. MÁRQUEZ-
RAMOS; A. HUANOSTA-GUTIÉRREZ; A. ADAYA-
VILLANUEVA; F. CALVO-VANEGAS; F. PENA*. Cinvestav-
Sede Sur.
8:45 320.4 The effects of human apoE on Amyloid-beta
pathology in a novel transgenic mouse model. K. L.
YOUMANS*; K. LAXTON; L. M. JUNGBAUER; C. YU; M.
LADU. Univ. Of Illinois Chicag.
9:00 320.5 � Early accumulation of the amyloid-β peptide in
human basal forebrain cholinergic neurons. S. VAHEDI; A.
BAKER-NIGH; D. RIASCOS; C. GEULA*. Northwestern Univ.,
Northwestern Univ. Med. Sch.
9:15 320.6 • Suggestive evidence that diffuse Abeta deposits and
senile plaques are generated by different mechanisms in AD.
L. N. NILSSON*; O. PHILIPSON; A. LORD; L. LANNFELT; P.
HAMMARSTRÖM; P. NILSSON; T. KLINGSTEDT. Uppsala
Univ., BioArctic Neurosci., Linköping Univ.
9:30 320.7 Neuritic plaque (NP) and neurofibrillary tangle (NFT)
densities are increased by compromised visual function in
patients with dementia. R. G. STRUBLE*; N. WILKINS; K.
SWONG; S. RANDALL; X. YAN; B. E. MOORE; T. ALA.
Southern Illinois Univ., Southern Illinois Univ. Sch. of Med.,
Mem. Med. Ctr.
9:45 320.8 Functional interaction between β-amyloid
precursor protein and DISC1: A link between schizophrenia
and Alzheimer’s disease. V. MURESAN; B. T. LAMB; Z.
MURESAN*. UMDNJ - New Jersey Med. Sch., Lerner Res.
Institute, The Cleveland Clin. Fndn.
10:00 320.9 Structural neuroplasticity and neurodegeneration
within the cortical connectome in mild cognitive impairment
and Alzheimer’s disease. R. F. MERVIS*; S. ARADI; V.
LOZANO; A. R. LOZANO; R. A. LONG; J. D. KOTICK;
A. WINKLER; M. SHAH; K. KASIMOS; J. J. MILLER; S.
SCHEFF; E. J. MUFSON. Univ. South Florida Coll Med.,
Neurostructural Res. Labs, Inc., Honors College, Univ. South
Florida, Univ. of Miami Miller Sch. of Med., USF Col. of Med.,
Univ. of Florida Col. of Med., Univ. of Kentucky, Rush Univ.
Med. Ctr.
10:15 320.10 • Characterization of a small molecule fluorophore
that preferentially binds soluble beta-amyloid oligomers in
the PDAPP transgenic mouse model of Alzheimer’s disease.
C. TAN HEHIR*; T. TANNER; Z. PANG; N. BARNHARDT; T.
MURRAY; J. KLIMASH. GE Global Res. Ctr.
10:30 320.11 Nitration of tyrosine 10 promotes amyloid β
aggregation and plaque formation. M. P. KUMMER*;
M. HERMES; T. HAMMERSCHMIDT; S. KUMAR; D.
TERWEL; J. WALTER; H. PAPE; S. KÖNIG; S. RÖBER;
T. KLOCKGETHER; M. HENEKA. Univ. of Bonn, Univ. of
Münster, IZKF Münster, Ludwig-Maximilian Univ.
4 | Society for Neuroscience
NANOSYMPOSIUM
321. Alzheimer’s Disease: Abeta Toxicity and Downstream
Effectors
Theme C: Disorders of the Nervous System
Mon. 8:00 AM — San Diego Convention Center, Room 23A
8:00 321.1 Role of neuronal STAT3 in the pathogenesis of
Alzheimer’s disease. T. CHIBA*; M. YAMADA; S. AISO; B.
GRONER. Georg Speyer Haus Inst. For Biomed. Res., KEIO
University, Sch. of Med.
8:15 321.2 Roles of heparan sulfate in Alzheimer’s
disease: Abeta depositon and cytotoxicity. X. ZHANG*; P.
O’CALLAGHAN; E. SANDWALL; T. H. VAN KUPPEVELT; L.
N. NILSSON; M. INGELSSON; B. T. HYMAN; H. KALIMO;
U. LINDAHL; L. LANNFELT; J. LI. Dept. of Publ. Hlth. and
Caring Sciences, Div. of Mol. Geriatric, Med. Biochem.
and Microbiology, Uppsala Univ., Biochemistry, Radbound
University, Nijmegen Med. Ctr., Neurology, Massachusetts
Gen. Hospital-East, Genet. and Patholgy, Uppsala Univ.
8:30 321.3 Glucose-oxygen deprivation and beta-amyloid
toxicity in entorhinal cortex: the role of RAGE. N. ORIGLIA*;
O. ARANCIO; S. YAN; L. DOMENICI. CNR, Columbia Univ.,
Univ. of L’Aquila.
8:45 321.4 Early deficits in synaptic mitochondria in an
Alzheimer’s disease mouse model. H. DU*; L. GUO; S. YAN;
A. A. SOSUNOV; G. M. MCKHANN; S. YAN. Columbia Univ.
9:00 321.5 Role of Phospholipase D2 and phosphatidic acid
signaling in Alzheimer’s disease-linked synaptic dysfunction
and cognitive deficits. T. G. OLIVEIRA*; R. B. CHAN; H. TIAN;
M. LAREDO; A. STANISZEWSKI; H. ZHANG; L. WANG; T.
KIM; K. E. DUFF; M. R. WENK; O. ARANCIO; G. DI PAOLO.
Columbia Univ., Life and Hlth. Sci. Res. Institute, Sch. of Hlth.
Sciences, Univ. of Minho, Natl. Univ. of Singapore.
9:15 321.6 Cyclophilin D deficiency protects against Aβ-induced
impairment in axonal mitochondrial trafficking. L. GUO*; H.
DU; S. YAN. Columbia Univ.
9:30 321.7 Chronic increase in VEGF along with amyloid-beta
in brain induce anti-angiogenic effect in mouse model of
Alzheimer’s disease. I. SINGH*; R. S. LOVE-KASISCHKE;
R. DEANE; H. H. MARTI; B. V. ZLOKOVIC. Univ. Rochester,
Univ. of Heidelberg.
9:45 321.8 D1/D5 receptor activation protects neurons from
synaptic dysfunction induced by Alzheimer’s Aβ oligomers. S.
JURGENSEN*; L. L. ANTONIO; G. MUSSI; E. R. GARRIDO-
SANABRIO; E. A. CAVALHEIRO; S. T. FERREIRA. Federal
Univ. of Rio De Janeiro, Federal Univ. of São Paulo, Federal
Univ. of Rio de Janeiro, Univ. of Texas at Brownsville.
10:00 321.9 Administration of soluble beta-amyloid 1-42
oligomers to the amygdala causes acute impairment of
fear-motivated learning and insulin signalling. A. BYRNE; J.
PEARSON-LEARY; E. C. MCNAY*. Univ. At Albany.
10:15 321.10 Role of the redox state of methionine 35 in
the synaptotoxicity of amyloid-β peptide. C. RIPOLI*; E.
RICCARDI; R. PIACENTINI; P. MAITI; G. BITAN; C. GRASSI.
Inst. of Human Physiology, Catholic Univ. Med. Sch., Dept. of
Neurology, David Geffen Sch. Medicine, UCLA.
10:30 321.11 Are some human brains able to tolerate the insult
of beta-amyloid? T. GOMEZ-ISLA*; O. DOLS; T. SCOTTON;
B. DA ROCHA-SOUTO; P. SANCHEZ-FERRER; A.
SERRANO-POZO; M. FROSCH; J. GROWDON; B. HYMAN.
Massachusetts Gen. Hosp.
• Indicated a real or perceived conflict of interest, see page 157 for details.
� Indicates a high school or undergraduate student presenter.