nanosymposium - Society for Neuroscience

november 15, 2010 

Scientific Sessions listings 

Sessions 310 – 516 

San Diego 

SoCiety for neuroSCienCe 

Final program 

Monday 

California

Information at a Glance 

important phone numbers 

Annual Meeting Headquarters Office — Logistics and Programming 

Logistics 

San Diego Convention Center: Sails Pavilion, (619) 525-6600 * 

Programming 

San Diego Convention Center: Sails Pavilion, (619) 525-6605 ** 

Society Executive Meeting Room 

San Diego Convention Center: Room 13, (619) 525-6650 *** 

General Information Booths 

San Diego Convention Center 

Lobby A, (619) 525-6670 

Lobby D, (619) 525-6671 

Sails Pavilion, (619) 525-6672 

Press Offices 

Press Room 

San Diego Convention Center: Room 15B, (619) 525-6640 

Exhibit Management 

San Diego Convention Center: Lobby D, (619) 525-6660 

First Aid and Hospital Numbers 

First Aid Room 

San Diego Convention Center: Lobby C, (619) 525-6615 

Scripps Mercy Hospital 

4077 5th Avenue 

San Diego, CA 92103 

(619) 294-8111 

* Annual meeting logistics, audiovisual, and advance registration inquiries. 

** Sessioning information for symposia, minisymposia, nanosymposia, poster sessions, special lectures, and socials for the 2010 and 2011 annual meetings. 

*** Matters of Council, Committees, and Past Presidents. 

Key to poster Floor by Themes 

The poster floor will begin with Theme A and end with Theme H. Refer to the poster floor map at the end of this booklet. 

Theme 

A Development 

B Neural Excitability, Synapses, and Glia: Cellular Mechanisms 

C Disorders of the Nervous System 

D Sensory and Motor Systems 

E Homeostatic and Neuroendocrine Systems 

F Cognition and Behavior 

G Novel Methods and Technology Development 

H History, Teaching, Public Awareness, and Societal Impacts in Neuroscience 

NOTE: Theme H Posters will be located in Halls B-H beginning at 1 p.m. on Saturday, Nov. 13, and will remain posted until 5 p.m., Sunday, Nov. 14.

Monday Highlights 

✍ Preregistration Required $ Course Fee � Professional Development ` Networking � Public Outreach 

Special Lecture 

Modern Genetic and Viral Tools for the 

Dissection of Neural Circuits CME 

Edward M. Callaway, PhD — The Salk Institute for 

Biological Studies 

8:30 – 9:40 a.m. 

San Diego Convention Center: Ballroom 20 

Symposium 

Experience-Dependent Synaptic Plasticity 

and Neurogenesis in the Degenerating and 

Injured Brain CME 

Chair: Michael W. Jakowec, PhD 

Co-chair: Carl W. Cotman, PhD 

8:30 – 11 a.m. 

San Diego Convention Center: Room 6B 

Symposium 

Transgenerational Inheritance and 

Epigenetics: Animal Models of 

Neuropsychiatric Disease CME 

Chair: Tracy L. Bale, PhD 

Co-chair: Frances A. Champagne, PhD 

8:30 – 11 a.m. 

San Diego Convention Center: Room 6A 

Minisymposium 

Dendritic Spine Dysfunction in 

Mental Disorders CME 

Chair: Peter Penzes, PhD 

Co-chair: David A. Lewis, MD 

8:30 – 11 a.m. 

San Diego Convention Center: Room 30E 

Minisymposium 

Molecular and Cellular Mechanisms of 

Axon Branching CME 

Chair: Le Ma, PhD 

Co-chair: Susana Cohen-Cory, PhD 

8:30 – 11 a.m. 


Minisymposium 

Toward the Second Generation of 

Optogenetic Tools CME 

Chair: Thomas Knopfel, MD 

Co-chair: Edward Boyden, PhD 

8:30 – 11 a.m. 

San Diego Convention Center: Room 29D 

Animals in Research Panel ✍ 

Conferring Legal Rights to Animals: 

Research in the Crosshairs 

9 – 11 a.m. 

San Diego Convention Center: Room 11 

Teaching Neuroscience: Undergraduate 

Curricula and Graduate Expectations � 

9 a.m. – noon 


The Secret to Success: How to 

Convey a Professional Image � 

9 a.m. – noon 


David Kopf Lecture on Neuroethics 

The Neuroscience Revolution and Society 

Henry T. Greely, JD — Stanford University 

Support contributed by: David Kopf Instruments 

10 – 11:10 a.m. 



Learning and Memory Mechanisms in Songbirds 

and Humans: Sleep On It! CME 

Dan Margoliash, PhD — University of Chicago 

11:30 a.m. – 12:40 p.m. 


Special Presentation 

A Neuroscience “Moonshot”: Rallying a New 

Global Race for Brain Research 

Rep. Patrick J. Kennedy (D-RI) — U.S. House 

of Representatives 

1 – 2 p.m. 


Symposium 

Molecular and Cellular Mechanisms of Memory 

Allocation in Neuronal Circuits CME 

Chair: Alcino J. Silva, PhD 

Co-chair: Sheena A. Josselyn, PhD 

1:30 – 4 p.m. 

San Diego Convention Center: Room 6F 

Symposium 

Visceral Nociception: Bidirectional Interaction 

Between the Viscera and Brain CME 

Chair: Matthew O. Fraser, PhD 

1:30 – 4 p.m. 

San Diego Convention Center: Room 6B 

Minisymposium 

Functional Interactions Between Stress and 

the Endocannabinoid System: From Synaptic 

Signaling to Behavioral Output CME 

Chair: Matthew N. Hill, PhD 

Co-chair: Jaideep S. Bains, PhD 

1:30 – 4 p.m. 


Minisymposium 

Molecular Pathways Controlling Development 

of Thalamus and Hypothalamus: From Neural 

Specification to Circuit Formation CME 

Chair: Seth Blackshaw, PhD 

Co-chair: Tomomi Shimogori, PhD 

1:30 – 4 p.m. 

San Diego Convention Center: Room 29D 

Minisymposium 

The Role of Acetylcholine in Cortical Processing 

and Plasticity CME 

Chair: Michael A. Silver, PhD 

1:30 – 4 p.m. 

San Diego Convention Center, Room 30E 

From Trainee to Independent 

Investigator: Funding Your Transitions � 

2 – 5 p.m. 


Albert and Ellen Grass Lecture 

Dendrites, From Form to Function CME 

Yuh Nung Jan, PhD and Lily Jan, PhD — University of 

California, San Francisco 

Support contributed by: The Grass Foundation 

3:15 – 4:25 p.m. 


Becoming an Engaged Member: 

Volunteer Opportunities with SfN � 

3:30 – 5 p.m. 


Presidential Special Lecture 

Learning to See Late in Life CME 

Pawan Sinha, PhD — Massachusetts Institute 

of Technology 

Support contributed by: Pfizer, Inc. 

5:15 – 6:25 p.m. 


Plan to Attend 

Tuesday, Nov. 16 


Genetic Dissection of the Mouse Brain: Toward a 

21st Century Brain Pharmacology CME 

Nathaniel Heintz, PhD — The Rockefeller University/ 

Howard Hughes Medical Institute 

8:30 – 9:40 a.m. 



How Do I Smell? A Guided Tour of Human and 

Insect Olfaction CME 

Leslie B. Vosshall, PhD — The Rockefeller University/ 

Howard Hughes Medical Institute 

11:30 a.m. – 12:40 p.m. 



Toward Understanding Schizophrenia and 

Bipolar Disorder CME 

Pamela Sklar, MD, PhD — Massachusetts General 

Hospital, Broad Institute 

1 – 2:10 p.m. 


History of Neuroscience Lecture 

Cell and Molecular Neurobiology: Antecedents 

and Achievements 

Victor P. Whittaker, PhD — Max Planck Institute 

Support contributed by: AstraZeneca 

2:30 – 3:40 p.m. 


Presidential Special Lecture 

Tuning Depression Circuits Using Deep Brain 

Stimulation CME 

Helen S. Mayberg, MD — Emory University 

Support contributed by: Lundbeck Research USA 

5:15 – 6:25 p.m. 


*Presented by an SfN partner organization 

www.sfn.org/am2010 I

Chronological List of Monday Sessions 

Theme Descriptions 

A Development 

B Neural Excitability, Synapses, and Glia: Cellular Mechanisms 

C Disorders of the Nervous System 

D Sensory and Motor Systems 

E Homeostatic and Neuroendocrine Systems 

II Neuroscience 2010 

F Cognition and Behavior 

G Novel Methods and Technology Development 

H History, Teaching, Public Awareness, and Societal Impacts 

in Neuroscience 

All Posters will be presented in the San Diego Convention Center, Halls B-H. All lecture, symposia, minisymposia, and nanosymposia rooms are in the 

San Diego Convention Center. 

NOTE: Theme H Posters will be located in Halls B-H beginning at 1 p.m. on Saturday, Nov. 13, and will remain posted until 5 p.m., Sunday, Nov. 14. 

Session 

Number 

Theme Title Presentation Type 

Poster-Board 

Number 

Location Session Time 

310 D Modern Genetic and Viral Tools for the Dissection of Neural Circuits Special Lecture Ballroom 20 8:30 – 9:40 a.m. 1.25 

311 C 

312 E 

Featured Programs 

Experience-Dependent Synaptic Plasticity and Neurogenesis in the 

Degenerating and Injured Brain 

Transgenerational Inheritance and Epigenetics: Animal Models of 

Neuropsychiatric Disease 

CME 

Credit 

Symposium Room 6B 8:30 – 11 a.m. 2.5 

Symposium Room 6A 8:30 – 11 a.m. 2.5 

313 A Molecular and Cellular Mechanisms of Axon Branching Minisymposium Room 6E 8:30 – 11 a.m. 2.5 

314 G Toward the Second Generation of Optogenetic Tools Minisymposium Room 29D 8:30 – 11 a.m. 2.5 

315 C Dendritic Spine Dysfunction in Mental Disorders Minisymposium Room 30E 8:30 – 11 a.m. 2.5 

316 The Neuroscience Revolution and Society 

David Kopf Lecture on 

Neuroethics 

317 F Learning and Memory Mechanisms in Songbirds and Humans: Sleep on It! Special Lecture 

Nanosymposia (8 a.m.–noon) 

MMM42- 

MMM52 

Ballroom 20 10 – 11:10 a.m. 

Ballroom 20 

11:30 a.m. – 

12:40 p.m. 

318 A Transplantation and Regeneration Nanosymposium Room 25A 8 – 10:15 a.m. 

319 B Presynaptic Mechanisms Nanosymposium Room 6F 8 – 10:45 a.m. 

320 C Alzheimer’s Disease: Abeta Assembly In Vitro and In Vivo Nanosymposium Room 32B 8 – 10:45 a.m. 

321 C Alzheimer’s Disease: Abeta Toxicity and Downstream Effectors Nanosymposium Room 23A 8 – 11:30 a.m. 

322 C Huntington’s Disease I Nanosymposium Room 10 8 – 11 a.m. 

323 C Genetic Approaches to Addiction Nanosymposium Room 31C 8 – 9:45 a.m. 

324 D Sound, Time, Movement, and Rhythm Nanosymposium Room 33C 8 – 11 a.m. 

325 D Vision: Response Properties Nanosymposium Room 1B 8 – 10:45 a.m. 

326 D Encoding of Visually Presented Objects I Nanosymposium Room 24A 8 – 11:30 a.m. 

327 D Perception across Movements Nanosymposium Room 5B 8 – 9:45 a.m. 

328 F Relational Memory Nanosymposium Room 7B 8 – 10:30 a.m. 

329 F Neural Bases of Negative Emotional States Nanosymposium Room 2 8 – 10:45 a.m. 

Posters (8 a.m.–noon) 

330 A Postnatal Neurogenesis II Poster A1-B14 Halls B-H 8 a.m. – noon 

331 A Human ESCs and iPSCs Poster B15-C7 Halls B-H 8 a.m. – noon 

332 A Axon Guidance: Cellular and Organismal Mechanisms Poster C8-C22 Halls B-H 8 a.m. – noon 

333 A Axon Development and Polarity Poster C23-D6 Halls B-H 8 a.m. – noon 

334 A Neuronal Cell Death I Poster D7-D13 Halls B-H 8 a.m. – noon 

335 A Visual Development: Retina, LGN, V1 Poster D14-D36 Halls B-H 8 a.m. – noon 

336 A Limbic System Development Poster D37-E7 Halls B-H 8 a.m. – noon 

1.25

Session 

Number 



Poster-Board 

Number 


337 B Neurotrophins: Regulation and Signaling Poster E8-E21 Halls B-H 8 a.m. – noon 

338 B GABA Receptors: Physiology I Poster E22-E47 Halls B-H 8 a.m. – noon 

339 B Sodium Channel Physiology I Poster E48-F19 Halls B-H 8 a.m. – noon 

340 B Potassium Channel Physiology I Poster F20-F43 Halls B-H 8 a.m. – noon 

341 B Calcium-Activated Potassium Channels Poster F44-G6 Halls B-H 8 a.m. – noon 

342 B Synaptic Transmission: Modulation by Ach, Amino Acids, and GABA Poster G7-G31 Halls B-H 8 a.m. – noon 

343 B Oscillations and Synchrony: EEG Studies Poster G32-G50 Halls B-H 8 a.m. – noon 

344 B Neuron-Glia Interactions and Astrocyte Activity I Poster G51-H17 Halls B-H 8 a.m. – noon 

345 B Neuron-Glia Interactions: Response to Cell Stress and Injury Poster H18-H41 Halls B-H 8 a.m. – noon 

346 C Inflammation and Neuron-Glia Interactions Poster H42-H58 Halls B-H 8 a.m. – noon 

347 C Tau: Role of Aggregated and Soluble Tau in Animal Models Poster H59-I18 Halls B-H 8 a.m. – noon 

348 C Aging: Animals and Humans Poster I19-J4 Halls B-H 8 a.m. – noon 

349 C Old Age Markers of Pathology Poster J5-K12 Halls B-H 8 a.m. – noon 

350 C Epilepsy: Epileptogenesis I Poster K13-M9 Halls B-H 8 a.m. – noon 

351 C Ischemia: Neurovascular Unit Poster M10-N10 Halls B-H 8 a.m. – noon 

352 C Ischemia: Oxidative Stress Poster N11-O6 Halls B-H 8 a.m. – noon 

353 C Ischemia: Models II Poster O7-P13 Halls B-H 8 a.m. – noon 

354 C Traumatic Brain Injury: Mechanisms I Poster P14-R11 Halls B-H 8 a.m. – noon 

355 C Traumatic Brain Injury: Mechanisms II Poster R12-S7 Halls B-H 8 a.m. – noon 

356 C Traumatic Brain Injury: Therapeutic Approaches I Poster S8-U1 Halls B-H 8 a.m. – noon 

357 C Spinal Cord Injury: Cellular and Molecular Mechanisms: Glia Poster U2-U17 Halls B-H 8 a.m. – noon 

358 C Spinal Cord Injury: Cellular and Molecular Mechanisms: Regeneration Poster U18-V17 Halls B-H 8 a.m. – noon 

359 C Neuroinflammation: Cellular and Molecular Mechanisms II Poster V18-X1 Halls B-H 8 a.m. – noon 

360 C Cell Death Mechanisms: DNA Damage and Repair Poster X2-X14 Halls B-H 8 a.m. – noon 

361 C Neurotoxicity and Neurodegeneration III Poster X15-Y15 Halls B-H 8 a.m. – noon 

362 C Molecular Mechanisms in Schizophrenia and Autism: Human Pathology Poster Y16-AA11 Halls B-H 8 a.m. – noon 

363 C Early Developmental Influences in Animal Models of Psychiatric Diagnoses Poster AA12-CC5 Halls B-H 8 a.m. – noon 

364 C Anxiety Disorders: Animal Models Poster CC6-DD6 Halls B-H 8 a.m. – noon 

365 C Alcohol: Tolerance Dependence and Withdrawal Poster DD7-FF4 Halls B-H 8 a.m. – noon 

366 C Neural Plasticity and Addiction II Poster FF5-GG3 Halls B-H 8 a.m. – noon 

367 C Psychostimulants: Developmental Effects Poster GG4-HH7 Halls B-H 8 a.m. – noon 

368 C Neural Mechanisms of Drug Addiction Poster HH8-II16 Halls B-H 8 a.m. – noon 

369 D Olfactory Bulb and Accessory Olfactory Bulb Poster II17-KK1 Halls B-H 8 a.m. – noon 

370 D Multisensory Interactions: Principles, Connections, Response Properties Poster KK2-LL1 Halls B-H 8 a.m. – noon 

371 D Striate Cortex: Plasticity and Reorganization Poster LL2-NN1 Halls B-H 8 a.m. – noon 

372 D Extrastriate Cortex: Visual Responses and Neural Coding Poster NN2-OO10 Halls B-H 8 a.m. – noon 

373 D Visually Guided Reaching Poster OO11-PP13 Halls B-H 8 a.m. – noon 

374 D Pain: Other Analgesics Poster PP14-QQ15 Halls B-H 8 a.m. – noon 

375 D Pain Models: Behavior Poster QQ16-RR20 Halls B-H 8 a.m. – noon 

376 D Neuropathic Pain: Ion Channels Poster SS1-SS19 Halls B-H 8 a.m. – noon 

377 D Cortical Reorganization and Plasticity Poster SS20-TT13 Halls B-H 8 a.m. – noon 

378 D Motor Neurons: Exercise, Injury, and Disease Poster TT14-UU8 Halls B-H 8 a.m. – noon 

CME 

Credit 

www.sfn.org/am2010 III

Session 

Number 


IV Neuroscience 2010 

Poster-Board 

Number 


379 D Muscle Physiology and Biochemistry Poster VV1-VV12 Halls B-H 8 a.m. – noon 

380 D Basal Ganglia: Systems Behavior Poster VV13-WW11 Halls B-H 8 a.m. – noon 

381 D Posture and Gait: Muscle Activity and Fatigue Poster WW12-XX16 Halls B-H 8 a.m. – noon 

382 D Cortical Interactions for Voluntary Movement Control Poster XX17-YY10 Halls B-H 8 a.m. – noon 

383 D BMI: Recording Methods and Information Processing Poster ZZ1-AAA18 Halls B-H 8 a.m. – noon 

384 E HPA Axis: Steroid Control Poster 

AAA19- 

BBB11 

Halls B-H 8 a.m. – noon 

385 E Steroids and Plasticity: Development and Sex Differences Poster BBB12-CCC3 Halls B-H 8 a.m. – noon 

386 E Sexual Differentiation Poster CCC4-DDD2 Halls B-H 8 a.m. – noon 

387 E Social Behavior: Neuropeptides Poster DDD3-FFF8 Halls B-H 8 a.m. – noon 

388 E Acute and Chronic Intermittent Hypoxia Poster FFF9-GGG3 Halls B-H 8 a.m. – noon 

389 E Cellular Actions of Stress I Poster GGG4-HHH4 Halls B-H 8 a.m. – noon 

390 E Stress and Cognition I Poster HHH5-HHH18 Halls B-H 8 a.m. – noon 

391 E Food Intake and Energy Balance: Integration of Peripheral Signals II Poster 

HHH19- 

HHH35 


392 E Energy Metabolism I Poster HHH36-III11 Halls B-H 8 a.m. – noon 

393 F Perception and Imagery: Face and Object Processing Poster III12-III41 Halls B-H 8 a.m. – noon 

394 F Perception and Imagery: Motion, Space, and Scenes Poster III42-JJJ8 Halls B-H 8 a.m. – noon 

395 F Motor and Sequence Learning Poster JJJ9-JJJ29 Halls B-H 8 a.m. – noon 

396 F Long-Term Memory: Retrieval Poster JJJ30-KKK8 Halls B-H 8 a.m. – noon 

397 F Long-Term Memory: Clinical Studies and Aging Poster KKK9-KKK26 Halls B-H 8 a.m. – noon 

398 F Long-Term Memory: Medial Temporal Lobe Studies Poster 

KKK27- 

KKK56 


399 F Attentional Modulation Poster KKK57-LLL8 Halls B-H 8 a.m. – noon 

400 F Language: Sensorimotor Integration and Production Poster LLL9-LLL21 Halls B-H 8 a.m. – noon 

401 F 


Decision Making: Basal Ganglia, Parietal Cortex, Motor Systems, and 

Learning 

Poster LLL22-LLL37 Halls B-H 8 a.m. – noon 

402 F Cognitive Development: Down Syndrome Poster LLL38-LLL56 Halls B-H 8 a.m. – noon 

403 F Social Cognition: Judgment and Attribution Poster LLL57-MMM1 Halls B-H 8 a.m. – noon 

404 F Learning and Memory Systems: Midbrain and Frontal Cortex Poster 

405 F Learning and Memory Systems: Neuronal Mechanisms Poster 

406 F Memory Consolidation and Reconsolidation: Molecular Mechanisms II Poster 

407 F Memory Consolidation and Reconsolidation: Molecular Mechanisms I Poster 

408 F Invertebrate Learning and Memory: Arthropod and Nematode Poster 

MMM2- 

MMM20 

MMM21- 

MMM48 

MMM49- 

MMM72 

MMM73- 

NNN24 

NNN25- 

NNN36 






409 F Invertebrate Learning and Memory: Mollusc Poster NNN37-OOO5 Halls B-H 8 a.m. – noon 

410 F Motivation and Emotion: Emotional Information Processing Poster OOO6-OOO15 Halls B-H 8 a.m. – noon 

411 F Neuroethology: Vocal Communication-Motor Mechanisms and Production Poster 

412 G Optogenetics II Poster 

413 G Novel Methods: Electrophysiology I Poster 

OOO16- 

OOO28 

OOO29- 

OOO42 

OOO43- 

OOO72 




CME 

Credit

Session 

Number 


414 G Neural Network Structure and Function: Theory Poster 

Poster-Board 

Number 

OOO73- 

PPP16 



415 G fMRI Methods Poster PPP17-PPP29 Halls B-H 8 a.m. – noon 

Featured Programs 

919 A Neuroscience “Moonshot”: Rallying a New Global Race for Brain Research Special Presentation Ballroom 20 1 – 2 p.m. 

416 F 

Molecular and Cellular Mechanisms of Memory Allocation in Neuronal 

Circuits 

CME 

Credit 

Symposium Room 6F 1:30 – 4 p.m. 2.5 

417 D Visceral Nociception: Bidirectional Interaction Between the Viscera and Brain Symposium Room 6B 1:30 – 4 p.m. 2.5 

418 E 

419 A 


Functional Interactions Between Stress and the Endocannabinoid System: 

From Synaptic Signaling to Behavioral Output 

Molecular Pathways Controlling Development of Thalamus and 

Hypothalamus: From Neural Specification to Circuit Formation 

Minisymposium Room 6E 1:30 – 4 p.m. 2.5 

Minisymposium Room 29D 1:30 – 4 p.m. 2.5 

420 F The Role of Acetylcholine in Cortical Processing and Plasticity Minisymposium Room 30E 1:30 – 4 p.m. 2.5 

421 Dendrites, From Form to Function 

Albert and Ellen Grass 

Lecture 

Ballroom 20 3:15 – 4:25 p.m. 1.25 

422 Learning to See Late in Life Presidential Special Lecture Ballroom 20 5:15 – 6:25 p.m. 1.25 

Nanosymposia (1–5 p.m.) 

423 A Postnatal Neurogenesis III Nanosymposium Room 25A 1 – 4:15 p.m. 

424 C Dementia Molecular Genetics and Proteome Nanosymposium Room 32B 1 – 2:15 p.m. 

425 C Huntington’s Disease: Animal Models I Nanosymposium Room 10 1 – 3 p.m. 

426 C Genetic Epilepsies Nanosymposium Room 24A 1 – 4 p.m. 

427 C Neuroinflammation and CNS Injury Nanosymposium Room 31C 1 – 4:15 p.m. 

428 C Neurotoxicity and Neurodegeneration IV Nanosymposium Room 23A 1 – 3 p.m. 

429 D Visual Cognition: Attentional Modulation of Neuronal and Network Activity Nanosymposium Room 5B 1 – 3:45 p.m. 

430 D TRP Channels and Pain Transduction Nanosymposium Room 33C 1 – 2:45 p.m. 

431 D Receptors: Cellular and Molecular Mechanisms of Transduction Nanosymposium Room 1B 1 – 3:15 p.m. 

432 E Mechanisms and Physiological Factors that Regulate Sleep Nanosymposium Room 6A 1 – 4:15 p.m. 

433 F Reward and Ultrasonic Vocalization Nanosymposium Room 2 1 – 3 p.m. 

434 G Optical Approaches to Explore the Nervous System Nanosymposium Room 7B 1 – 2:45 p.m. 

Posters (1–5 p.m.) 

435 A Proliferation III Poster A1-B12 Halls B-H 1 – 5 p.m. 

436 A Cell Migration II Poster B13-C1 Halls B-H 1 – 5 p.m. 

437 A Neuronal Differentiation II Poster C2-C30 Halls B-H 1 – 5 p.m. 

438 A Glial Differentiation Poster C31-D18 Halls B-H 1 – 5 p.m. 

439 A Synaptic Adhesion Molecules Poster D19-E1 Halls B-H 1 – 5 p.m. 

440 A Development: Activity-Dependent Modulation of Connectivity I Poster E2-E26 Halls B-H 1 – 5 p.m. 

441 A Evolution and Development Poster E27-E50 Halls B-H 1 – 5 p.m. 

442 B Acetylcholine Poster E51-F8 Halls B-H 1 – 5 p.m. 

443 B GABA Receptors: Physiology II Poster F9-F26 Halls B-H 1 – 5 p.m. 

444 B Adenosine and ATP: Basic and Translational Research Poster F27-F38 Halls B-H 1 – 5 p.m. 

445 B Sodium Channel Physiology II Poster F39-F54 Halls B-H 1 – 5 p.m. 

446 B Potassium Channel Physiology II Poster F55-G18 Halls B-H 1 – 5 p.m. 

447 B Neurotransmitter Release: Calcium-Dependence Poster G19-G30 Halls B-H 1 – 5 p.m. 

www.sfn.org/am2010 V

Session 

Number 



VI Neuroscience 2010 

Poster-Board 

Number 


448 B Synaptic Transmission: Presynaptic Structure and Function Poster G31-G54 Halls B-H 1 – 5 p.m. 

449 B Synaptic Transmission: Postsynaptic Structure and Function Poster G55-H22 Halls B-H 1 – 5 p.m. 

450 B Synaptic Transmission: Synaptic Integration Poster H23-H44 Halls B-H 1 – 5 p.m. 

451 B Synaptic Plasticity: Short-Term Plasticity Poster H45-H59 Halls B-H 1 – 5 p.m. 

452 B Synaptic Plasticity: LTP Kinases and Signaling Poster H60-I16 Halls B-H 1 – 5 p.m. 

453 B Synaptic Plasticity: Presynaptic Mechanisms Poster I17-I23 Halls B-H 1 – 5 p.m. 

454 B Oscillations and Synchrony: Modulation by Receptors Poster I24-I38 Halls B-H 1 – 5 p.m. 

455 C Alzheimer’s Disease: Abeta and Inflammation Poster I39-J14 Halls B-H 1 – 5 p.m. 

456 C APP Processing Poster J15-K12 Halls B-H 1 – 5 p.m. 

457 C Alzheimer’s Disease: APP, APP/PS1 Animal Models Poster K13-M10 Halls B-H 1 – 5 p.m. 

458 C Metabolism and Toxicity of Alpha-Synuclein III Poster M11-N14 Halls B-H 1 – 5 p.m. 

459 C Deep Brain Stimulation Poster N15-P4 Halls B-H 1 – 5 p.m. 

460 C Parkinson’s Disease: Neuroprotective Strategies Poster P5-Q13 Halls B-H 1 – 5 p.m. 

461 C Genetic Parkinson’s Disease Poster Q14-S7 Halls B-H 1 – 5 p.m. 

462 C Motor Neuron Disease Pathology Poster S8-U2 Halls B-H 1 – 5 p.m. 

463 C Autism: Genetic and Animal Models III Poster U3-V14 Halls B-H 1 – 5 p.m. 

464 C Epilepsy: Epileptogenesis II Poster V15-X6 Halls B-H 1 – 5 p.m. 

465 C Ischemia: Cellular and Molecular Mechanisms II Poster X7-Y7 Halls B-H 1 – 5 p.m. 

466 C Ischemia: Neuroprotection II Poster Y8-Z14 Halls B-H 1 – 5 p.m. 

467 C Traumatic Brain Injury: Animal Models Poster AA1-BB12 Halls B-H 1 – 5 p.m. 

468 C Spinal Cord Injury: Human Studies and Animal Models Poster BB13-DD7 Halls B-H 1 – 5 p.m. 

469 C Spinal Cord Injury: Transplantation: Stem Cells and Embryonic Tissue Poster DD8-EE11 Halls B-H 1 – 5 p.m. 

470 C Cell Death and Neurprotective Mechanisms: Apotosis and Caspases Poster EE12-FF17 Halls B-H 1 – 5 p.m. 

471 C Genetic Models with Schizophrenia Risk Genes Poster FF18-HH11 Halls B-H 1 – 5 p.m. 

472 C Novel Pharmacologic Approaches in Psychotic Diagnoses Poster HH12-II16 Halls B-H 1 – 5 p.m. 

473 C Alcohol: Neural Mechanisms Poster II17-KK7 Halls B-H 1 – 5 p.m. 

474 C Alcohol: Developmental Adolescence Poster KK8-LL3 Halls B-H 1 – 5 p.m. 

475 C Nicotine: Molecular Mechanisms of Addiction Poster LL4-MM8 Halls B-H 1 – 5 p.m. 

476 C Nicotine: Neural Mechanisms of Addiction Poster MM9-OO8 Halls B-H 1 – 5 p.m. 

477 C Amphetamines: Toxicity I Poster OO9-PP10 Halls B-H 1 – 5 p.m. 

478 C Addiction: Genetics Poster PP11-QQ3 Halls B-H 1 – 5 p.m. 

479 D Olfactory Cortex, Anterior Olfactory Nucleus, and Olfactory Amygdala Poster QQ4-QQ18 Halls B-H 1 – 5 p.m. 

480 D Auditory Processing: Sound Localization and Binaural Interactions Poster QQ19-RR17 Halls B-H 1 – 5 p.m. 

481 D Auditory Processing: Temporal and Spectral Factors I Poster RR18-SS14 Halls B-H 1 – 5 p.m. 

482 D Auditory Processing: Cortical Circuits, Synapses, and Neurotransmitters Poster SS15-TT10 Halls B-H 1 – 5 p.m. 

483 D Striate Cortex: Functional Organization Poster TT11-VV4 Halls B-H 1 – 5 p.m. 

484 D Striate Cortex: Receptive Fields and Response Properties Poster VV5-WW9 Halls B-H 1 – 5 p.m. 

485 D Visual Cognition: Working and Short-Term Memory Poster WW10-WW19 Halls B-H 1 – 5 p.m. 

486 D Eye Movements: Clinical and Normal Populations Poster WW20-XX12 Halls B-H 1 – 5 p.m. 

487 D Pain Imaging and Perception Poster XX13-YY10 Halls B-H 1 – 5 p.m. 

488 D Neuropathic Pain: Glia Poster ZZ1-AAA9 Halls B-H 1 – 5 p.m. 

489 D Rhythmic Motor Pattern Cellular Properties: Invertebrate and Theory Poster AAA10-BBB2 Halls B-H 1 – 5 p.m. 

CME 

Credit

Session 

Number 


Poster-Board 

Number 


490 D Rhythmic Pattern Generation Cellular Properties: Vertebrate Poster BBB3-CCC1 Halls B-H 1 – 5 p.m. 

491 D Basal Ganglia: Neurotransmitters Poster CCC2-DDD5 Halls B-H 1 – 5 p.m. 

492 D Voluntary Reaching: Movement Selection and Strategy Poster DDD6-FFF13 Halls B-H 1 – 5 p.m. 

493 D Voluntary Reaching: Motor Learning Poster FFF14-GGG12 Halls B-H 1 – 5 p.m. 

494 D Motor Cortex and Voluntary Movement Control Poster 

495 E Sexual Behavior: Steroid Mechanisms Poster 

GGG13- 

HHH20 

HHH21- 

HHH32 

Halls B-H 1 – 5 p.m. 


496 E Early Life Experience: Postnatal/Juvenile/Adolescent Stress Poster HHH33-III6 Halls B-H 1 – 5 p.m. 

497 E Early Life Experience: Prenatal Factors Poster III7-III23 Halls B-H 1 – 5 p.m. 

498 E Food Intake and Energy Balance: Neuropeptides II Poster III24-III48 Halls B-H 1 – 5 p.m. 

499 E Circadian Physiology Poster III49-JJJ29 Halls B-H 1 – 5 p.m. 

500 E Sleep Neurochemistry and Molecular Biology I Poster JJJ30-KKK5 Halls B-H 1 – 5 p.m. 

501 F Neural Attentional Network Poster KKK6-KKK29 Halls B-H 1 – 5 p.m. 

502 F Typical and Disordered Language Development Poster 

503 F Decision Making: Perception, Cognition, Neural Corrrelates Poster 

KKK30- 

KKK50 

KKK51- 

KKK67 



504 F Cognitive Aging: Encoding and Memory Poster KKK68-LLL12 Halls B-H 1 – 5 p.m. 

505 F Timing and Temporal Processing: Human Studies Poster LLL13-LLL40 Halls B-H 1 – 5 p.m. 

506 F Neural Mechanisms and Pharmacology: Underlying Attention Poster LLL41-LLL67 Halls B-H 1 – 5 p.m. 

507 F Schizophrenia: Anxiety, Vocalization, Environment Poster 

508 F Impulse Control Disorders: Attentional Impairments Poster 

509 F Learning and Memory Systems: Genetic and Pharmacological Manipulation Poster 

510 F Memory Consolidation and Reconsolidation: Behavior Poster 

511 F Reward: Neurocircuitry Poster 

LLL68- 

MMM16 

MMM17- 

MMM41 

MMM42- 

MMM69 

MMM70- 

NNN13 

NNN14- 

NNN43 






512 F Motivation and Emotion: Neuropharmacology of Decision Making Poster NNN44-OOO5 Halls B-H 1 – 5 p.m. 

513 F Neuroethology: Social Behavior, Aggression, and Arousal Poster OOO6-OOO20 Halls B-H 1 – 5 p.m. 

514 G Novel Biochemical Techniques Poster 

515 G Advances in Cellular and Molecular Technology I Poster 

516 G Neuronatomy: Automation, Stereology, and Microscopy Poster 

W23 


Workshops, Meetings & Events 

Animals in Research Panel — Conferring Legal Rights to Animals: 


OOO21- 

OOO39 

OOO40- 

OOO69 

OOO70- 

PPP21 




Workshops/Meetings Room 11 9 – 11 a.m. 

W24 Teaching Neuroscience: Undergraduate Curricula and Graduate Expectations Workshops/Meetings Room 4 9 a.m. – noon 

W25 The Secret to Success: How to Convey a Professional Image Workshops/Meetings Room 3 9 a.m. – noon 

W26 From Trainee to Independent Investigator: Funding Your Transitions Workshops/Meetings Room 3 2 – 5 p.m. 

W27 Becoming an Engaged Member: Volunteer Opportunities with SfN Workshops/Meetings Room 4 3:30 – 5 p.m. 

CME 

Credit 

www.sfn.org/am2010 VII

Monday Workshops, Meetings & Events 

✍ Preregistration Required $ Course Fee � Professional Development ` Networking � Public Outreach 

Monday, Nov. 15 

Animals in Research Panel ✍ 

Conferring Legal Rights to Animals: 


Monday, Nov. 15, 9 – 11 a.m. 


Organizer: Sharon Juliano, PhD 

Speakers: Roberto Caminiti, MD; Michael Conn, PhD; 

Richard Cupp, JD 

Contact: Laura Martin, lmartin@sfn.org 

With more than 100 law schools now offering 

at least one animal law course, the field 

has expanded dramatically in the past decade. 

With this growth comes an increased focus 

on seeking to grant animals the same rights 

as humans, or personhood, which would 

have significant ramifications for all research. 

How is this growing legal strategy already 

impacting animal research? What does its 

continued expansion mean for neuroscience, 

other research, and even the family pet? 

How should the science community engage 

to address this trend? The panel will address 

these questions. Breakfast will be served. 

Teaching Neuroscience: Undergraduate 

Curricula and Graduate Expectations � 

Monday, Nov. 15, 9 a.m. – noon 


Organizer: Richard Olivo, PhD 

Contact: Liz Larabell, llarabell@sfn.org 

This year’s teaching workshop focuses on the 

undergraduate neuroscience curriculum and 

its match (or mismatch) with the expectations 

of graduate admissions committees. 

We will survey representative undergraduate 

programs, see detailed examples of the curriculum 

for two college programs (one that 

evolved from a psychology track and one 

centered in biology), and hear the expectations 

of three graduate admissions committees 

that seek prior strength in cellular and 

molecular biology, cognitive and systems 

neuroscience, or quantitative and physical 

sciences. The workshop will conclude with 

a general discussion, followed by breakout 

groups for faculty teaching similar courses. 

VIII Neuroscience 2010 

The Secret to Success: How to 

Convey a Professional Image � 

Monday, Nov. 15, 9 a.m. – noon 


Organizer: Yi E. Sun, PhD 


How to project a professional image has never 

been something we are trained for during 

our career development, but it is a critical 

determinant between getting a job or just getting 

interviews. If you have wondered about 

the secret to effectively presenting yourself 

and your brilliant science, and being highly 

influential when delivering your lectures in 

class or at scientific meetings, we are here 

to help! During this workshop, we will have 

four well-established, highly influential 

female scientists reveal their insight into the 

different aspects of professional image. 

From Trainee to Independent 

Investigator: Funding Your Transitions � 

Monday, Nov. 15, 2 – 5 p.m. 


Organizers: Andres Barria, PhD; Anne Etgen, PhD 


This workshop provides information on funding 

sources to assist early career scientists 

(predoctoral fellows, postdoctoral fellows, and 

junior faculty) in transitioning to independent 

investigator. The focus will be on two 

career transition points: (1) from predoctoral 

to postdoctoral training, and (2) from postdoctoral 

fellow to first independent faculty 

position. Representatives of federal agencies 

and private foundations that provide fellowships 

for postdoctoral fellows and early career 

scientists will describe a variety of programs, 

some restricted to U.S. citizens and permanent 

residents (e.g., NIH National Research Service 

Awards and most K awards; NSF Postdoctoral 

Research Fellowships and CAREER Awards) 

and others open to international trainees and 

investigators (e.g., the Fogarty International 

Center and American Heart Association). The 

presentations include information on strategies 

for selecting the most appropriate mechanism 

and preparing a competitive application. 

After the presentations and a question/answer 

period, representatives will be available to 

discuss specific programs and make appointments 

to meet with potential candidates. 

Becoming an Engaged Member: 

Volunteer Opportunities with SfN � 

Monday, Nov. 15, 3:30 – 5 p.m. 


Organizer: Freda Miller, PhD 


Have you ever wondered how to become 

an engaged and active member of your 

professional society? SfN offers varied ways 

to get involved and serve the neuroscience 

profession — including the 13 standing 

and business committees — while developing 

leadership skills and building your CV. 

This practical workshop includes the ins and 

outs of SfN committee and Council service, 

as well as volunteer opportunities in public 

education, advocacy, mentoring, professional 

development, and local chapter-led activities. 

Find faculty and speakers at www.sfn.org/workshops

Monday Socials 

Monday, Nov. 15, 6:45 – 8:45 p.m. 

Alzheimer’s Disease Social 

Purely Social 

San Diego Marriott Hotel & Marina: Torrey 2 & 3 

Chair: Rudolph E. Tanzi 

Alzheimer Idol Karaoke Night is back by 

popular demand. Join us for a night of 

entertainment and enjoyment. Belt out your 

favorite tunes and watch your colleagues 

embarrass themselves. Graduate students 

and postdocs are especially encouraged to 

participate. Organize your laboratory to present 

your favorite Alzheimer theme tunes. 

The names of the winners of the best performance 

competition will be forwarded to 

network television for further consideration. 

Autonomic and Respiratory Control 

Social: Creativity in a Competitive World 

Social with Brief Presentation 

San Diego Marriott Hotel & Marina: Marriott Hall Salon 1 & 2 

Chair: Stephen M. Johnson 

This social is for those interested in neural 

control of respiratory, cardiovascular, and 

autonomic function to meet after a long day of 

posters and talks. It’s a great opportunity for 

younger scientists to mingle informally with 

established investigators. A brief presentation 

will be used to start a discussion on how creativity 

leads to significant advances in our field. 

Behavioral Neuroendocrinology Social: 

Frank’s Beach 

Social with Brief Presentation 

San Diego Marriott Hotel & Marina: Marriott Hall Salon 5 & 6 

Chairs: Tracy L. Bale, Marc J. Tetel 

Guests: Greg Ball, Peg McCarthy, Geert DeVries, 

Nancy Forger, Anne Murphy, Larry Young, Marc Tetel, 

Emilie Rissman, Jeff Blaustein 

Organized by the Society for Behavioral 

Neuroendocrinology (SBN), an interdisciplinary 

scientific organization dedicated to the 

study of hormonal processes and neuroendocrine 

systems that regulate behavior. There 

will be a social gathering hosted by Regis and 

Kelly along with a presentation honoring the 

recipient of the 2010 Frank A. Beach Award. 

Developmental Neurobiology Social 

Purely Social 

San Diego Marriott Hotel & Marina: New York, Orlando 

Chair: Joe LoTurco 

An informal social to meet with friends 

and colleagues interested in the development 

of the nervous system. 

Faculty for Undergraduate 

Neuroscience Social 

Social and Poster Session 

San Diego Marriott Hotel & Marina: 

Marriott Hall Salon 3 & 4 

Chair: Christopher A. Korey 

Guests: J.R. Yates, S. Dickinson 

Socialize and exchange ideas with others 

interested in undergraduate neuroscience 

research and education. Undergraduates 

will present posters of their research, and 

FUN Student Travel Awards and Educator 

of the Year Award will be presented. SOMAS 

awardees and their students will be introduced 

(see www.somasprogram.org). See the 

FUN Web site for travel award information 

and registration for poster presentations 

at the FUN Social (www.funfaculty.org). 

Hippocampus Social 

Purely Social 

San Diego Marriott Hotel & Marina: Atlanta, Chicago 

Chair: James J. Knierim 

Guests: H. Scharfman, R. Gage, L. Nadel, M. Shapiro, T. 

Sacktor, R. Burwell, J. Bachevalier, W. Suzuki 

If you can remember, come to the 

Hippocampus Social and watch luminaries 

in the field test their visual imagination and 

drawing skills in a game of HippoPictionary! 

Ingestive Behavior Social: 

Quench Your Appetite for Appetite 

Purely Social 

San Diego Marriott Hotel & Marina: Torrey 1 

Chair: Alan C. Spector 

Guests: H.R. Berthoud, B. Levin, P.S. Grigson, T. Moran, 

L. Rinaman, J. Roth, A. Watts 

Information overload? Come and relax with 

your ingestive behavior colleagues. Have 

significant conversations (p

Monday Satellite Events & Non-SfN Socials 

Full descriptions and the latest details on these satellite events and socials not sponsored by SfN are 

available online at www.sfn.org/satellites. These events also are available in the online Neuroscience 

Meeting Planner (NMP). Attendees can access the NMP on-site or at www.sfn.org/nmp. 

Title For More Information Time Location Room 

Monday, November 15 

7th Annual Christopher Reeve “Hot Topics” in Stem 

Cell Biology 

blarraga@burnham.org 6:30 – 10 p.m. Convention Center Room 30ABCDE 

Armenian Neuroscientist Social anazarian@westernu.edu 6:30 – 8:30 p.m. Convention Center Room 27A 

Axon Electrophysiology User Meeting www.moleculardevices.com 6:30 – 8:30 p.m. 

Chinese Neuroscientists Social 

Darwin’s Doubt: Can Naturalistically Evolved Human 

Minds Be Trusted to Yield True Beliefs About Reality? 

Drexel University College of Medicine 

Alumni Reception 

ESF and FENS European Workshop on European-U.S. 

Collaborative Research 

Gait Analysis: An Essential Behavioral Task in 

Phenotyping and CNS Disorders 

www.nibs.ac.cn/index. 

php?act=view&id=624 

San Diego Marriott 

Hotel & Marina 

San Diego Ballroom C 

6:30 – 8:30 p.m. Hilton Bayfront Sapphire EF 

www.cneuroscience.org 7 – 8:30 p.m. Convention Center Room 10 

www.drexelmed.edu 6:30 – 8 p.m. 

www.fens.org 6:45 – 8:30 p.m. 





Oceanside 

Warner Center 

yqliang@cleversysinc.com 7 – 9 p.m. Hilton Bayfront Indigo 204B 

Iranian Neuroscientists Social www.irnsc.net 6:30 – 8:30 p.m. 

Mayo Neurobiology of Disease Program 

Alumni Reception 

www.mayo.edu/mgs/ 6:30 – 8:30 p.m. 





Newport Beach 

MBL/Grass Foundation Social kshaw@mbl.edu 6:30 – 8 p.m. Hilton Bayfront Sapphire 410 

Meet the Editors: How to Get Published in Major 

Neuroscience Journals! 

www.ibro.info/Pub/Pub_Main_ 

Display.asp?LC_Docs_ID=3939 

Neuroscience in Mexico: Past, Present, and Future lrocha@cinvestav.mx 6:30 – 8:30 p.m. 

Neuroscience of Sleep and Circadian Biology DataBlitz laposkya@nhlbi.nih.gov 8 – 10 p.m. 

NIH Grant Workshop for Early Career Investigators 

Nucleic Acids to the Rescue: Gene and Antisense 

Oligonucleotide Therapies for SMA 

Patient HM 

Pitfalls of Cell-Based Screening Assays — Is it the 

Cell, the Assay or the Question Asked? 

Puerto Rican Neuroscientists Social 

Salk/UCSD Neurosciences: A Celebration of Friends 

and Family 

www.nida.nih.gov/about/organization/ 

DBNBR/PICNRB.html 

X Neuroscience 2010 www.sfn.org/satellites 

Laguna 

6:30 – 8 p.m. Manchester Grand Hyatt Randle Ballroom AB 

6:30 – 10 p.m. 







Marina Ballroom 

Salon D 

www.smafoundation.org 6:30 – 9 p.m. Manchester Grand Hyatt Ford ABC 

www.brownpapertickets.com/ 

event/118853 

www.carolinasmedicalcenter.org/ 

body.cfm?id=1574 

www.cienciapr.org/viewprofile. 

php?username=moefeliu 

7 – 8:30 p.m. 

Lyceum Space Theatre, 

79 Horton Plaza 

San Diego Ballroom 

Salon B 

Rancho Las Palmas 

6:30 – 8:30 p.m. Hilton Bayfront Indigo 206 

8 – 10 p.m. The FleetWood 

wmobley@ucsd.edu 6:30 – 10 p.m. The Salk Institute 

Schizophrenia Research Social www.worldeventsforum.com 6:30 – 8:30 p.m. Convention Center Room 2 

Sleep Research Society Club Hypnos www.sleepresearchsociety.org/ 6:30 – 8 p.m. 



San Diego Ballroom 

Salon A 

The Brain on Trial drunkle@aaas.org 6:30 – 9:30 p.m. Manchester Grand Hyatt Madeleine A-D 

UAB Comprehensive Neuroscience Social www.uab.edu/cnc 6:30 – 8:30 p.m. 

Washington University in St. Louis 

Neuroscience Reception 

pearcet@wusm.wustl.edu 6:30 – 9:30 p.m. 



Rock Bottom Restaurant 

and Brewery 

Santa Rosa

SPECIAL LECTURE San Diego Convention Center 

310. Modern Genetic and Viral Tools for the Dissection of 

Neural Circuits CME 

• Indicated a real or perceived conflict of interest, see page 157 for details. 

� Indicates a high school or undergraduate student presenter. 

Complete Session Listing 

Mon. 8:30 AM - 9:40 AM — Ballroom 20 

Speaker: E. M. CALLAWAY, The Salk Inst. for Biol. Studies. 

To understand how neural circuits function, it is necessary to 

resolve connectivity with high resolution, correlate connectivity 

with function, and manipulate activity of defined circuit 

components. Advances in genetic and viral tools make this 

possible at the resolution of specific cell types and even single 

neurons. A discussion of methods for identifying connectivity 

and how they can be used to understand circuit function, will 

be followed by description of work in my lab, developing and 

using rabies virus-based systems for tracing neural circuits 

and linking them to function. 

SYMPOSIUM San Diego Convention Center 

311. Experience-Dependent Synaptic Plasticity and 

Neurogenesis in the Degenerating and Injured 

Brain CME 

Mon. 8:30 AM - 11:00 AM — Room 6B 

Chair: M. W. JAKOWEC 

Co-Chair: C. W. COTMAN 

The role of experience in modeling the brain has become 

a field of great scientific interest. This symposium will 

highlight recent developments in understanding the role of 

experience, in the form of exercise and the environment, in 

modifying synaptic structure and function and neurogenesis 

in neurodegenerative disorders (Parkinson’s and Alzheimer’s 

diseases), models of injury (ischemia), and aging. The effect 

of experience on behavior, pathology and synaptic function 

will be discussed. 

8:30 311.1 Introduction. 

8:35 311.2 Mechanisms of experience dependent 

neuroplasticity and the role of neurotrophic factors in animal 

models of Alzheimer’s disease. C. W. COTMAN. UC Irvine. 

9:10 311.3 The effects of intensive exercise on synaptic 

function in the striatum of the MPTP-lesioned mouse model of 

Parkinson’s disease. G. PETZINGER. USC. 

9:45 311.4 Experience-dependent synaptic structural and cell 

proliferative events in stroke models. T. A. JONES. Univ. 

Texas Austin. 

10:20 311.5 • Evolutionary diversity of brain aging in primates: are 

humans unique? C. E. FINCH. Univ. of Southern California. 

10:55 311.6 Closing Remarks. 

Monday AM 


312. Transgenerational Inheritance and Epigenetics: Animal 

Models of Neuropsychiatric Disease CME 

Mon. 8:30 AM - 11:00 AM — Room 6A 

Chair: T. L. BALE 

Co-Chair: F. A. CHAMPAGNE 

The overall objective of this symposium is to discuss the latest 

information on transgenerational epigenetic inheritance of 

stress-mediated traits and the molecular mechanisms behind 

them. This fast-paced field has moved into 2nd and 3rd 

generations to identify novel epigenetic programming events 

involved in disease risk. The expert speakers will discuss 

stress influences across developmental time points utilizing 

cutting-edge analyses including evaluation of miRNAs, 

histones and DNA methylation. 


8:35 312.2 Transgenerational impact of postnatal social 

enrichment via maternal and paternal transmission. F. A. 

CHAMPAGNE. Columbia Univ. 

9:10 312.3 Transmission of the effect of postnatal stress on 

offspring behavior across generations in the mouse. I. M. 

MANSUY. University/ETH Zürich. 

9:45 312.4 Maternal stress and glucocorticoids: programming 

neuroendocrine function and behavior across generations. S. 

G. MATTHEWS. Fac. of Medicine, Univ. of Toronto. 

10:20 312.5 • Prenatal stress programming of transgenerational 

outcomes via the paternal lineage. T. L. BALE. Univ. 

Pennsylvania. 


MINISYMPOSIUM San Diego Convention Center 

313. Molecular and Cellular Mechanisms of Axon 

Branching CME 

Mon. 8:30 AM - 11:00 AM — Room 6E 

Chair: L. MA 

Co-Chair: S. COHEN-CORY 

Axon branching is a developmental process that allows 

one neuron to connect with multiple targets and is critical in 

generating complex neuronal circuits. The minisymposium will 

dedicate to recent studies using molecular, genetic, imaging 

and modeling approaches to understand this fundamental 

process. Speakers will highlight the latest advances in 

elucidating the molecular and cellular principles of branching 

regulation during development and plasticity of the nervous 

system. 


8:35 313.2 Molecular control of axon arbor growth: BDNF and 

netrin-1 act as multifunctional cues to modulate visual circuit 

development. S. COHEN-CORY. Univ. California Irvine. 

8:55 313.3 Wnt5a regulates axonal branching and growth in 

developing sympathetic neurons. R. KURUVILLA. Johns 

Hopkins Univ. 

Neuroscience 2010 | Monday AM | 1 

Mon. AM

9:15 313.4 Regulation of spinal sensory afferent bifurcation by 

Slit and CNP signaling. L. MA. USC. 

9:35 313.5 Dynamics and molecular control of axon branching 

in vivo. M. C. HALLORAN. Univ. Wisconsin. 

9:55 313.6 In vivo imaging of axonal dynamics in the 

mammalian neocortex. V. DE PAOLA. Imperial Col. London. 

10:15 313.7 Optimal axonal and dendritic branching strategies 

during the development of retinotopic maps. D. TSIGANKOV. 

Max-Planck-Institute for Dynamics and Self-Organization. 



314. • Towards the Second Generation of Optogenetic 

Tools CME 

Mon. 8:30 AM - 11:00 AM — Room 29D 

Chair: T. KNOPFEL 

Co-Chair: E. BOYDEN 

The optogenetic toolbox involves genetically encoded 

actuators and reporters, proteins that allow using light 

to control or to monitor molecular processes in neural 

systems. Optical methods enable fast and spatially well 

resolved experimental manipulations and measurements. 

A first generation of genetically-encoded calcium reporters, 

fluorescent proteins, and neural activators has already had 

great impact on neuroscience; a second generation of voltage 

reporters, neural silencers, and extended fluorescent proteins 

bears great promise to continue this revolution. Speakers 

will be particularly encouraged to highlight limitations of the 

presently available optogenic tools and discuss where the 

technologies are headed in the future. 


8:35 314.2 • Novel optical neural control tools: towards enabling 

integrative analysis of neural systems. E. S. BOYDEN. MIT. 

8:55 314.3 New generation of voltage sensitive fluorescent 

proteins for in vivo imaging of neuronal circuit dynamics. T. 

KNOPFEL. RIKEN Brain Sci. Inst. 

9:15 314.4 Choosing the right channelrhodopsin variant for your 

neuroscientific experiment. J. Y. LIN. UCSD. 

9:35 314.5 Optogenetic control of signal transduction via a lightgated 

protein-protein interaction. A. LEVSKAYA. UCSF. 

9:55 314.6 Red shifted fluorescent proteins for in vivo imaging. 

M. Z. LIN. UCSD. 

10:15 314.7 Imaging neural activity with genetically encoded 

calcium indicators. L. TIAN. HHMI Janelia Res. Campus. 



315. • Dendritic Spine Dysfunction in Mental Disorders CME 

Mon. 8:30 AM - 11:00 AM — Room 30E 

Chair: P. PENZES 

Co-Chair: D. A. LEWIS 

Speakers will discuss recent research and conceptual 

advances regarding the dysregulation of structural plasticity 

at spiny synapses in mental disorders. We will focus on 

schizophrenia and autism, where a role for abnormal synaptic 

plasticity and connectivity is well documented. Talks will 

explore cellular neuropathological alterations and their 

potential genetic and mechanistic underpinnings, which 

may involve the disruption of signaling by small GTPases, 

neuregulin, DISC1, kalirin-7, neuroligin, and Epac2. 


8:35 315.2 Transgenic expression of Neuregulin 1, type IV 

regulates synaptic maturation in vitro and impairs cortical 

function in mice. A. J. LAW. NIMH, NIH. 

8:55 315.3 • Molecular mechanisms of lamina-specific dendritic 

spine alterations in in schizophrenia. D. A. LEWIS. Univ. of 

Pittsburgh. 

9:15 315.4 Disrupted in synapse by Disrupted-in-Schizophrenia 

1 (DISC1): dendritic spine pathogenesis in schizophrenia. A. 

HAYASHI. RIKEN Brain Sci. Inst. 

9:35 315.5 Synaptic spine distribution and morphology on 

cortical projection neurons in autism spectrum disorders. J. J. 

HUTSLER. Univ. of Nevada. 

9:55 315.6 Aberrant neuroligin function in autism. C. ZHANG. 

Stanford Univ. Sch. of Med. 

10:15 315.7 Regulation of dendritic spine dynamics by autismassociated 

synaptic molecules. P. PENZES. Nothwestern 

Univ. Feinberg Sch. Med. 


DAVID KOPf LECTURE ON NEUROEThICS San Diego 

Convention Center 

316. The Neuroscience Revolution and Society 

Mon. 10:00 AM - 11:10 AM — Ballroom 20 

Speaker: H. T. GREELY, Stanford Univ. 

Support contributed by David Kopf Instruments 

The onrushing revolution in neuroscience will change not 

just science and medicine, but all aspects of human society. 

This lecture will outline six different ways neuroscience 

will affect society, through findings that concern prediction, 

mindreading, responsibility, consciousness, treatment for 

disfavored behaviors, and cognitive enhancement. It will 

end by suggesting ways in which neuroscience might more 

deeply affect our understandings of our fellow humans - and 

of ourselves. 

2 | Society for Neuroscience • Indicated a real or perceived conflict of interest, see page 157 for details. 

� Indicates a high school or undergraduate student presenter.

SPECIAL LECTURE San Diego Convention Center 

317. Learning and Memory Mechanisms in Songbirds and 

humans: Sleep on It! CME 

Mon. 11:30 AM - 12:40 PM — Ballroom 20 

Speaker: D. MARGOLIASH, Univ. Chicago. 

In humans and animals, sleep has a wide range of effects 

on memory formation. Birdsong learning, a model of 

vocal learning, demonstrates the role of sleep in sensory 

memorization and sensorimotor learning. Studying birdsong 

from the perspective of sleep is helping us to understand 

how vocal learning is integrated in the brain, and is informing 

our understanding of sleep and learning processes in other 

systems. 

NANOSYMPOSIUM 

318. Transplantation and Regeneration 

Theme A: Development 

Mon. 8:00 AM — San Diego Convention Center, Room 25A 

8:00 318.1 Crosstalk between SOCS3 and PTEN regulated 

pathways in promoting optic nerve regeneration. F. SUN*; K. 

K. PARK; Z. HE. Children’s Hosp. Boston. 

8:15 318.2 • Hydrogen peroxide promotes peripheral sensory 

axon regeneration after epidermal injury. S. RIEGER*; A. 

SAGASTI. Univ. of California Los Angeles. 

8:30 318.3 • Neural signal regeneration and function rebuilding 

with microelectronic neural bridge between two separated 

toads 1000-km apart. Z. WANG*; X. LÜ; W. LI; X. SHEN; Z. 

HUANG; X. ZHAO; L. DU; X. GAO; Z. JIANG; H. PAN; G. 

WANG; S. XIE; X. GONG; C. ZHU; L. QIU. Southeast Univ., 

China Rehabil. Res. Ctr., Nanjing Med. Univ., Nantong Univ. 

8:45 318.4 Synergistic interactions between endogenous 

and transplanted neural precursor cells in the parkinsonian 

rat. L. MADHAVAN*; B. F. DALEY; R. L. BOUDREAU; B. 

L. DAVIDSON; A. COLE-STRAUSS; J. W. LIPTON; T. J. 

COLLIER. Univ. of Cincinnati, Univ. of Iowa, Michigan State 

Univ. 

9:00 318.5 • Functional regeneration of the meso-cortico-limbic 

dopaminergic system as a model to study novel neuroreparative 

strategies. E. DOSSI; C. HEINE; L. COLOMBO; F. 

GULLO; A. MAFFEZZOLI; M. P. ABBRACCHIO; H. FRANKE; 

P. ILLES; E. WANKE*. Univ. Milano-Bicocca, Univ. of Leipzig, 

Univ. of Milan. 

9:15 318.6 Substrate stretch enhances axonal outgrowth but 

inhibits process branching and dendritic outgrowth of motor 

neurons. J. M. COREY*; M. K. LEACH; Z. FENG; Y. I. NAIM. 

Univ. Michigan, VA Ann Arbor Healthcare Ctr., Southeast Univ. 

9:30 318.7 Degenerating tracts do not provide a strong 

guidance cue for regenerating optic axons: Observations 

in the astray/robo2 mutant. C. WYATT*; A. EBERT; M. M. 

REIMER; K. RASBAND; C. B. CHIEN; T. BECKER; C. G. 

BECKER. The Univ. of Edinburgh, Univ. of Utah Sch. of Med. 

9:45 318.8 Tetracycline-regulated lentiviral neurotrophin-3 gene 

delivery for axonal bridging after spinal cord injury. S. HOU*; 

L. NICHOLSON; M. TUSZYNSKI; A. BLESCH. UCSD, VA 

Med. Ctr., Univ. of Heidelberg. 

10:00 318.9 Pten deletion rejuvenates the regenerative ability 

of adult corticospinal neurons. K. LIU*; Y. LU; J. LEE; 

R. SAMARA; K. PARK; I. SEARS-KRAXBERGER; R. 

WILLENBERG; A. TEDESCHI; B. CAI; B. XU; L. CONNOLLY; 

O. STEWARD; B. ZHENG; Z. HE. Children’s Hosp. Boston/ 

Harvard Med. Sch., UCSD, UCIrvine. 



NANOSYMPOSIUM 

319. Presynaptic Mechanisms 

Theme B: Neural Excitability, Synapses, and Glia: Cellular 

Mechanisms 

Mon. 8:00 AM — San Diego Convention Center, Room 6F 

8:00 319.1 Genetic analysis of synaptogyrin’s role in the 

synaptic vesicle cycle. R. J. STEVENS*; Y. AKBERGENOVA; 

R. A. JORQUERA; J. T. LITTLETON. MIT. 

8:15 319.2 Synaptic vesicle recycling in vivo. A. DENKER*; 

I. BETHANI; K. KRÖHNERT; S. O. RIZZOLI. European 

Neurosci. Inst., Intl. Max Planck Res. Sch. Mol. Biol. 

8:30 319.3 Assessment of cis-SNARE complex formation and 

different modalities of syntaxin dispersion during synaptic 

transmission in hippocampal neurons. V. DEGTYAR*; R. S. 

ZUCKER. Bogomoletz Inst. Physiol, Univ. of California. 

8:45 319.4 Stochiometry of SNARE complexes sufficient for 

fast calcium-triggered exocytosis in central nervous system 

synapses. R. SINHA*; J. KLINGAUF. Max-Planck Inst. For 

Biophysical Chem. 

9:00 319.5 Role of syntaxin 1 phosphorylation in 

neurotransmitter release: Implications for schizophrenia. 

H. MATTHIES; M. A. CASTILLO; A. GALLI; P. G. ULERY- 

REYNOLDS*. Vanderbilt Univ., Univ. Texas Southwestern 

Med. Ctr. 

9:15 319.6 Cholesterol sensitive kinases regulate 

neurotransmitter release. A. J. SMITH*; S. SUGITA; M. P. 

CHARLTON. Univ. Toronto, Toronto Western Res. Inst. 

9:30 319.7 Complexins facilitate exocytosis and synchronize 

release by coupling vesicles and calcium channels. M. LIN; J. 

G. ROHAN; K. REIM; N. BROSE; C. KO; R. H. CHOW*. USC, 

Keck USC Sch. Med., Max Planck Inst. for Exptl. Med. 

9:45 319.8 Triggering clathrin uncoating is the major function 

of endophilin at neuronal synapses. I. MILOSEVIC*; S. 

GIOVEDI; X. LOU; A. RAIMONDI; S. PARADISE; O. 

CREMONA; P. DE CAMILLI. Yale Univ., IFOM and Univ. Vita– 

Salute San Raffaele. 

10:00 319.9 Optogenetic glutamate corelease from dopamine 

terminals in the nucleus accumbens of adult mice is 

dependent on VGLUT2. T. S. HNASKO*; G. D. STUBER; J. P. 

BRITT; A. BONCI; R. H. EDWARDS. Univ. of California, San 

Francisco, Ernest Gallo Clin. & Res. Ctr. 

10:15 319.10 Efflux of stored acetylcholine from intact synapticlike 

microvesicles. S. M. PARSONS*; A. MULAKALURI. Univ. 

California. 

10:30 319.11 High and low mobility stages in the synaptic vesicle 

cycle. D. KAMIN*; M. A. LAUTERBACH; V. WESTPHAL; 

S. W. HELL; S. O. RIZZOLI. European Neurosci. Inst., Max 

Planck Inst. for Biophysical Chem. 

NANOSYMPOSIUM 

320. Alzheimer’s Disease: Abeta Assembly In Vitro and In Vivo 

Theme C: Disorders of the Nervous System 

Mon. 8:00 AM — San Diego Convention Center, Room 32B 

8:00 320.1 • Site-specific denaturation and Raman spectroscopy 

reveal structural differences between the Aβ oligomers. L. 

BREYDO*; D. KUROUSKI; S. RASOOL; S. MILTON; J. WU; 

I. V. LEDNEV; C. G. GLABE. Univ. of California Irvine, Univ. of 

Albany. 


Mon. AM NANOSYMPOSIUM

NANOSYMPOSIUM 

8:15 320.2 Elucidation of amyloid β-protein oligomerization 

pathways in the absence and presence of toxicity inhibitors: 

A multiscale computational study. B. URBANC*; B. BARZ; M. 

BETNEL; L. CRUZ; G. BITAN; D. B. TEPLOW. Drexel Univ., 

Boston Univ., David Geffen Sch. of Med. at UCLA. 

8:30 320.3 Amyloid beta oligomers decrease hippocampal 

network activity: Involvement of the Integrin/FAK/Fyn/GSK3 

signaling pathway. H. BALLEZA-TAPIA; A. MÁRQUEZ- 

RAMOS; A. HUANOSTA-GUTIÉRREZ; A. ADAYA- 

VILLANUEVA; F. CALVO-VANEGAS; F. PENA*. Cinvestav- 

Sede Sur. 

8:45 320.4 The effects of human apoE on Amyloid-beta 

pathology in a novel transgenic mouse model. K. L. 

YOUMANS*; K. LAXTON; L. M. JUNGBAUER; C. YU; M. 

LADU. Univ. Of Illinois Chicag. 

9:00 320.5 � Early accumulation of the amyloid-β peptide in 

human basal forebrain cholinergic neurons. S. VAHEDI; A. 

BAKER-NIGH; D. RIASCOS; C. GEULA*. Northwestern Univ., 

Northwestern Univ. Med. Sch. 

9:15 320.6 • Suggestive evidence that diffuse Abeta deposits and 

senile plaques are generated by different mechanisms in AD. 

L. N. NILSSON*; O. PHILIPSON; A. LORD; L. LANNFELT; P. 

HAMMARSTRÖM; P. NILSSON; T. KLINGSTEDT. Uppsala 

Univ., BioArctic Neurosci., Linköping Univ. 

9:30 320.7 Neuritic plaque (NP) and neurofibrillary tangle (NFT) 

densities are increased by compromised visual function in 

patients with dementia. R. G. STRUBLE*; N. WILKINS; K. 

SWONG; S. RANDALL; X. YAN; B. E. MOORE; T. ALA. 

Southern Illinois Univ., Southern Illinois Univ. Sch. of Med., 

Mem. Med. Ctr. 

9:45 320.8 Functional interaction between β-amyloid 

precursor protein and DISC1: A link between schizophrenia 

and Alzheimer’s disease. V. MURESAN; B. T. LAMB; Z. 

MURESAN*. UMDNJ - New Jersey Med. Sch., Lerner Res. 

Institute, The Cleveland Clin. Fndn. 

10:00 320.9 Structural neuroplasticity and neurodegeneration 

within the cortical connectome in mild cognitive impairment 

and Alzheimer’s disease. R. F. MERVIS*; S. ARADI; V. 

LOZANO; A. R. LOZANO; R. A. LONG; J. D. KOTICK; 

A. WINKLER; M. SHAH; K. KASIMOS; J. J. MILLER; S. 

SCHEFF; E. J. MUFSON. Univ. South Florida Coll Med., 

Neurostructural Res. Labs, Inc., Honors College, Univ. South 

Florida, Univ. of Miami Miller Sch. of Med., USF Col. of Med., 

Univ. of Florida Col. of Med., Univ. of Kentucky, Rush Univ. 

Med. Ctr. 

10:15 320.10 • Characterization of a small molecule fluorophore 

that preferentially binds soluble beta-amyloid oligomers in 

the PDAPP transgenic mouse model of Alzheimer’s disease. 

C. TAN HEHIR*; T. TANNER; Z. PANG; N. BARNHARDT; T. 

MURRAY; J. KLIMASH. GE Global Res. Ctr. 

10:30 320.11 Nitration of tyrosine 10 promotes amyloid β 

aggregation and plaque formation. M. P. KUMMER*; 

M. HERMES; T. HAMMERSCHMIDT; S. KUMAR; D. 

TERWEL; J. WALTER; H. PAPE; S. KÖNIG; S. RÖBER; 

T. KLOCKGETHER; M. HENEKA. Univ. of Bonn, Univ. of 

Münster, IZKF Münster, Ludwig-Maximilian Univ. 

4 | Society for Neuroscience 

NANOSYMPOSIUM 

321. Alzheimer’s Disease: Abeta Toxicity and Downstream 

Effectors 



8:00 321.1 Role of neuronal STAT3 in the pathogenesis of 

Alzheimer’s disease. T. CHIBA*; M. YAMADA; S. AISO; B. 

GRONER. Georg Speyer Haus Inst. For Biomed. Res., KEIO 

University, Sch. of Med. 

8:15 321.2 Roles of heparan sulfate in Alzheimer’s 

disease: Abeta depositon and cytotoxicity. X. ZHANG*; P. 

O’CALLAGHAN; E. SANDWALL; T. H. VAN KUPPEVELT; L. 

N. NILSSON; M. INGELSSON; B. T. HYMAN; H. KALIMO; 

U. LINDAHL; L. LANNFELT; J. LI. Dept. of Publ. Hlth. and 

Caring Sciences, Div. of Mol. Geriatric, Med. Biochem. 

and Microbiology, Uppsala Univ., Biochemistry, Radbound 

University, Nijmegen Med. Ctr., Neurology, Massachusetts 

Gen. Hospital-East, Genet. and Patholgy, Uppsala Univ. 

8:30 321.3 Glucose-oxygen deprivation and beta-amyloid 

toxicity in entorhinal cortex: the role of RAGE. N. ORIGLIA*; 

O. ARANCIO; S. YAN; L. DOMENICI. CNR, Columbia Univ., 

Univ. of L’Aquila. 

8:45 321.4 Early deficits in synaptic mitochondria in an 

Alzheimer’s disease mouse model. H. DU*; L. GUO; S. YAN; 

A. A. SOSUNOV; G. M. MCKHANN; S. YAN. Columbia Univ. 

9:00 321.5 Role of Phospholipase D2 and phosphatidic acid 

signaling in Alzheimer’s disease-linked synaptic dysfunction 

and cognitive deficits. T. G. OLIVEIRA*; R. B. CHAN; H. TIAN; 

M. LAREDO; A. STANISZEWSKI; H. ZHANG; L. WANG; T. 

KIM; K. E. DUFF; M. R. WENK; O. ARANCIO; G. DI PAOLO. 

Columbia Univ., Life and Hlth. Sci. Res. Institute, Sch. of Hlth. 

Sciences, Univ. of Minho, Natl. Univ. of Singapore. 

9:15 321.6 Cyclophilin D deficiency protects against Aβ-induced 

impairment in axonal mitochondrial trafficking. L. GUO*; H. 

DU; S. YAN. Columbia Univ. 

9:30 321.7 Chronic increase in VEGF along with amyloid-beta 

in brain induce anti-angiogenic effect in mouse model of 

Alzheimer’s disease. I. SINGH*; R. S. LOVE-KASISCHKE; 

R. DEANE; H. H. MARTI; B. V. ZLOKOVIC. Univ. Rochester, 

Univ. of Heidelberg. 

9:45 321.8 D1/D5 receptor activation protects neurons from 

synaptic dysfunction induced by Alzheimer’s Aβ oligomers. S. 

JURGENSEN*; L. L. ANTONIO; G. MUSSI; E. R. GARRIDO- 

SANABRIO; E. A. CAVALHEIRO; S. T. FERREIRA. Federal 

Univ. of Rio De Janeiro, Federal Univ. of São Paulo, Federal 

Univ. of Rio de Janeiro, Univ. of Texas at Brownsville. 

10:00 321.9 Administration of soluble beta-amyloid 1-42 

oligomers to the amygdala causes acute impairment of 

fear-motivated learning and insulin signalling. A. BYRNE; J. 

PEARSON-LEARY; E. C. MCNAY*. Univ. At Albany. 

10:15 321.10 Role of the redox state of methionine 35 in 

the synaptotoxicity of amyloid-β peptide. C. RIPOLI*; E. 

RICCARDI; R. PIACENTINI; P. MAITI; G. BITAN; C. GRASSI. 

Inst. of Human Physiology, Catholic Univ. Med. Sch., Dept. of 

Neurology, David Geffen Sch. Medicine, UCLA. 

10:30 321.11 Are some human brains able to tolerate the insult 

of beta-amyloid? T. GOMEZ-ISLA*; O. DOLS; T. SCOTTON; 

B. DA ROCHA-SOUTO; P. SANCHEZ-FERRER; A. 

SERRANO-POZO; M. FROSCH; J. GROWDON; B. HYMAN. 

Massachusetts Gen. Hosp. 



10:45 321.12 Increased brain vulnerability to systemic 

inflammation in Alzheimer disease mouse model. S. 

TAKEDA*; N. SATO; H. RAKUGI; R. MORISHITA. Dept. of 

Clin. Gene Therapy, Osaka Unuversity, Dept. of Geriatric 

Medicine, Grad. Sch. of Medicine, Osaka Univ. 

11:00 321.13 • Pyroglutamate-modified β-amyloid amplifies 

tau-dependent cytotoxicity of conventional β-amyloid. J. 

NUSSBAUM,; H. CYNIS; S. SCHILLING; H. DEMUTH; G. S. 

BLOOM*. Univ. of Virginia, Probiodrug AG, Univ. Virginia. 

11:15 321.14 Amyloid beta mediated glutamate release from 

astrocytes. S. SANZ-BLASCO*; J. PINA-CRESPO; M. 

TALANTOVA; G. CAO; S. A. LIPTON. SANFORD-BURNHAM 

MEDICAL RESEARCH INSTITUTE. 

NANOSYMPOSIUM 

322. huntington’s Disease I 


Mon. 8:00 AM — San Diego Convention Center, Room 10 

8:00 322.1 � Tissue-specific targeting of lentiviral vectors for 

CNS applications. A. DELZOR*; I. NASCIMENTO-FERREIRA; 

N. DUFOUR; G. AUREGAN; N. DÉGLON. Atomic Energy 

Commission, CNRS URA2210, Ctr. for Neurosciences and 

Cell Biol. 

8:15 322.2 The striatal marker Dclk3 is neuroprotective against 

mutant huntingtin. E. P. BROUILLET*; L. GALVAN; M. 

GAILLARD; G. LIOT; M. DE CHALDÉE; G. AURÉGAN; N. 

DUFOUR; M. GUILLERMIER; M. CHAIGNEAU; F. PETIT; C. 

MALGORN; J. ELALOUF; S. HUMBERT; N. DÉGLON. CEA, 

MIRCen, URA CEA-CNRS 2210, Insitut Curie, UMR3306 

CNRS, U1005 Inserm, CEA, IBITec, SBIGem. 

8:30 322.3 The role of deregulated miR-200a expression in 

mutant huntingtin-induced neuronal dysfunction. J. JIN*; Y. 

CHENG; Y. ZHANG; W. H. WOOD, III; Q. PENG; M. JIANG; 

J. FU; O. PLETNIKOVA; J. C. TRONCOSO; C. A. ROSS; K. 

G. BECKER; W. DUAN. Johns Hopkins Univ. Sch. of Med., 

NIA, NIH. 

8:45 322.4 Treatment of Huntington’s disease using a novel 

dual-function adenosine compound. Y. CHERN*; J. LIN; J. 

CHEN; H. CHEN. Inst. Biomed Sci., Boston Univ. Sch. of Med. 

9:00 322.5 Proteastasis of polyglutamine varies among neurons 

and predicts proneness to degeneration. A. TSVETKOV*; M. 

ARRASATE; P. SHARMA; S. FINKBEINER. Univ. California 

- San Francisco, the Taube-Koret Ctr. for Huntington’s Dis. 

Res., Gladstone Inst. of Neurolog. Dis. and the Taube-Koret 

Ctr. for Huntington’s Dis. Res. 

9:15 322.6 Live imaging of mutant huntingtin oligomerization in 

cell cultures. F. HERRERA*; S. TENREIRO; T. F. OUTEIRO. 

Inst. De Medicina Mol. 

9:30 322.7 Rhes, implicated in huntington’s disease, induces 

and binds to endoplasmic reticulum (er) stress markers, 

pdi and perk. S. SUBRAMANIAM*; N. SHAHANI; M. R. 

ROBBERT; S. H. SNYDER. Johns Hopkins Univ. Sch. of 

Med., Johns Hopkins Sch. of Med. 

9:45 322.8 The MID1 / protein phosphatase 2A proteincomplex 

regulates the translation of mRNAs with CAGrepeats. 

S. SCHWEIGER*; S. KRAUSS; D. RUTSCHOW; 

E. JASTRZEBSKA; C. ACHMUELLER; E. WANCKER; R. 

SCHNEIDER. Univ. of Dundee, Max-PLanck Inst. for Mol. 

Genet., Univ. Innsbruck, Max-Delbrueck Ctr. for Mol. Med. 



10:00 322.9 RNA< RNA-binding protein and the pathogenesis 

of Huntington’s and Huntington’s disease-like 2. D. D. 

RUDNICKI*; J. L. PRUITT; R. L. MARGOLIS. Johns Hopkins 

Univ., Johns Hopkins Sch. of Med. 

10:15 322.10 Over-expression of PGC-1α alleviates huntingtin 

protein toxicity by restoring mitochondrial activity and 

enforcing the ROS defense system in vitro and in vivo. T. 

TSUNEMI; A. R. LA SPADA*. UCSD. 

10:30 322.11 Variable pattern of cortical interneuron loss in 

the human brain in Huntington’s disease correlates with 

symptom profiles. E. KIM*; D. C. V. THU; A. L. NANA; D. E. 

OORSCHOT; B. J. SYNEK; V. M. HOGG; L. J. TIPPETT; H. J. 

WALDVOGEL; R. L. M. FAULL. Univ. of Auckland, Brain Mind 

Institute, École Polytechnique Fédérale de Lausanne (EPFL), 

Univ. of Otago, Auckland City Hosp. 

10:45 322.12 Proteomic analysis of redox sensitive proteins in a 

Huntington’s disease cell model reveals Peroxiredoxin-1 as 

a target for thiol-based antioxidants. R. C. CUMMING*; A. 

PITTS; K. DAILEY. Univ. of Western Ontario. 

NANOSYMPOSIUM 

323. Genetic Approaches to Addiction 


Mon. 8:00 AM — San Diego Convention Center, Room 31C 

8:00 323.1 Addiction neurobiology: Support from human gene 

variants identified by moderate p values in each of multiple 

independent samples. G. R. UHL*; T. DRGON; C. JOHNSON; 

D. WALTHER; M. NINO. NIH/NIDA. 

8:15 323.2 Prefrontal white matter is influenced by catecholo-methyl 

transferase (COMT) val158met polymorphism 

in substance users and healthy controls. X. ZHANG*; D. 

J. STEIN; B. SALMERON; M. LEE; M. LEE; X. GENG; C. 

HODGKINSON; P. SHEN; Y. YANG; D. GOLDMAN; E. A. 

STEIN. NIH, Nat’L Inst. On Drug Abuse, Univ. of Cape Town. 

8:30 323.3 • Activation within the self-related processing 

network to tailored health messages mediates the influence 

of the STin2 genotype on smoking cessation outcome. A. J. 

JASINSKA*; H. F. CHUA; S. S. HO; T. A. POLK; L. ROZEK; 

V. J. STRECHER. Neurosci. Program, Univ. of Michigan, Hlth. 

Behavior and Hlth. Education, Univ. of Michigan, Psychiatry, 

Univ. of Michigan, Psychology, Univ. of Michigan, Envrn. Hlth. 

Science, Univ. of Michigan. 

8:45 323.4 Case-control association analysis for polymorphisms 

in the mu-opioid receptor interacting protein candidate gene, 

GPR177, and cocaine dependence. L. M. AMBROSE-LANCI*; 

P. J. BLOCH; C. S. SHEEKEY; T. N. FERRARO; K. M. 

KAMPMAN; C. A. DACKIS; H. M. PETTINATI; C. P. O’BRIEN; 

F. W. LOHOFF; W. H. BERRETTINI. Univ. of Pennsylvania. 

9:00 323.5 • OPRM1 gene: Functional polymorphism in Exon 

I and correlation with susceptibility to alcohol and opiate 

dependence. S. KAPUR*; A. PAL; S. SHARAD; L. DHAKA. 

Birla Inst. of Technol. and Sci. (BITS), Pilani, Rajasthan, 

India-33303, Ctr. for Prostate Dis. Research, Uniformed 

Service Univ., BDK Hosp. 

9:15 323.6 Analysis of the brain transcriptome using RNA 

sequencing: Genetics of exon use and alternative splicing. K. 

MOZHUI*; X. WANG; M. K. MULLIGAN; Z. LI; L. LU; R. W. 

WILLIAMS. Univ. Tennessee HSC. 

9:30 323.7 Comparative primate genetics: A new tool for 

neuroscience connecting function and disease. E. J. 

VALLENDER*; D. M. PLATT; G. M. MILLER. Harvard Med. 

Sch, NEPRC. 



NANOSYMPOSIUM 

NANOSYMPOSIUM 

324. Sound, Time, Movement, and Rhythm 

Theme D: Sensory and Motor Systems 

Mon. 8:00 AM — San Diego Convention Center, Room 33C 

8:00 324.1 • Functional reorganization of the auditorymotor 

integration network following ventral premotor 

cortex disruption: Evidence from offline rTMS-fMRI. K. 

KORNYSHEVA*; R. I. SCHUBOTZ. Max Planck Inst. For 

Neurolog. Res., Univ. Col. London, Inst. of Cognitive Neurosci. 

8:15 324.2 Multimodal mirror responses for different effectors: 

Convergence and divergence of sensorimotor processing. Z. 

K. AGNEW*; C. MCGETTIGAN; S. K. SCOTT. UCL Inst. of 

Cognitive Neurosci. 

8:30 324.3 Entrainment to complex rhythms: Tests of a neural 

model. M. J. VELASCO*; L. MAURER; E. W. LARGE. Florida 

Atlantic Univ. 

8:45 324.4 Rhythm processing decomposed: EEG of perceived 

and self-imposed rhythmic patterns. R. S. SCHAEFER*; R. J. 

VLEK; P. DESAIN. Radboud Univ. Nijmegen. 

9:00 324.5 The impact of basal ganglia or cerebellar lesions on 

attention-dependent temporal processing. M. SCHWARTZE*; 

S. A. KOTZ. Max Planck Inst. For Human Cognitive and Brain 

Sci. 

9:15 324.6 The basal ganglia in perceptual timing: The 

effects of Parkinson’s disease and deep-brain stimulation. 

M. GRUBE*; A. MANDAL; T. E. COPE; F. E. COOPER; U. 

BRECHANY; D. J. BURN; T. D. GRIFFITHS. Newcastle Univ., 

Newcastle Gen. Hosp. 

9:30 324.7 Neuromagnetic oscillation in musical meter and beat 

processing. T. FUJIOKA*; B. R. ZENDEL; B. ROSS. Rotman 

Res. Inst. 

9:45 324.8 Neural dynamics of beat perception. J. R. 

IVERSEN*; A. D. PATEL. The Neurosciences Inst. 

10:00 324.9 1/f temporal structure and prediction in rhythmic 

entrainment. S. K. RANKIN*; E. W. LARGE. Univ. Florida 

Atlantic. 

10:15 324.10 Inter-subject brain synchrony during listening 

to natural auditory scenes. D. AKKAL*; J. KATSYRI; S. 

MALINEN; O. KALLIOINEN; S. PAMILO; Y. HLUSHCHUK; P. 

TIKKA; S. CARLSON; R. HARI. Aalto Univ. Sch. of Sci. and 

Technol., Aalto Univ. Sch. of Econ., Aalto Univ. Sch. of Art and 

Design, Univ. of Helsinki. 

10:30 324.11 Distinct representation of absolute and relative 

auditory time. S. TEKI*; M. GRUBE; S. KUMAR; T. D. 

GRIFFITHS. Wellcome Trust Ctr. For Neuroimaging, Med. 

School, Newcastle Univ. 

10:45 324.12 Population coding in auditory cortex - time 

scales and intrinsic reference frames. C. KAYSER*; N. 

K. LOGOTHETIS; S. PANZERI. Max Planck Inst. Biol 

Cybernetics, Italian Inst. of Technol. 


NANOSYMPOSIUM 

325. Vision: Response Properties 



8:00 325.1 Human monochromatic light discrimination 

explained by optimal decoding of cone absorptions. L. 

ZHAOPING*. Univ. Col. London. 

8:15 325.2 The adaptive field and predictive object 

representation in the retina. D. B. KASTNER*; S. A. BACCUS. 

Stanford Univ. 

8:30 325.3 Differential receptive properties of parvalbumin- and 

somatostatin-containing cortical inhibitory neurons. W. MA; 

B. LIU; L. I. ZHANG; Z. J. HUANG; H. TAO*. USC Keck Sch. 

Med., Cold Spring Harbor Lab. 

8:45 325.4 Differences in the 2-D structure of V1 receptive 

fields mapped with different stimulus ensembles. C. YEH*; D. 

XING; R. M. SHAPLEY. New York Univ. 

9:00 325.5 Development and specificity of the non-classical 

receptive field during naturalistic stimulation in mouse primary 

visual cortex. M. PECKA*; T. D. MRSIC-FLOGEL. Univ. Col. 

London. 

9:15 325.6 Linear summation of feedforward corticocortical 

inputs. A. ZANDVAKILI*; A. KOHN. Albert Einstein Col. of 

Med. 

9:30 325.7 The jigsaw puzzle in V1: Influences of surrounding 

context on non-stimulated early visual regions is independent 

of memory and basic visual features. F. W. SMITH*; L. 

MUCKLI. Univ. of Western Ontario, Univ. of Glasgow. 

9:45 325.8 Task-dependent shape selectivity in primary visual 

cortex. J. N. MCMANUS*; W. LI; C. D. GILBERT. Rockefeller 

Univ., Beijing Normal Univ. 

10:00 325.9 Tomographic characterization of population 

receptive fields in early visual cortex. C. A. GREENE; S. O. 

DUMOULIN; B. M. HARVEY; D. RESS*. Univ. Texas Austin, 

Utrecht Univ. 

10:15 325.10 Modeling center-surround configurations in 

population receptive fields using fMRI. W. ZUIDERBAAN*; 

D. RESS; B. M. HARVEY; C. A. GREEN; S. O. DUMOULIN. 

Utrecht Univ., Univ. of Texas at Austin. 

10:30 325.11 Motion integration receptive field effects in human 

fMRI. B. M. HARVEY*; S. DUMOULIN. Utrecht Univ. 

NANOSYMPOSIUM 

326. Encoding of Visually Presented Objects I 



8:00 326.1 Voxels in LO can distinguish objects with different 

arrangements of the same component parts. M. D. 

LESCROART*; I. BIEDERMAN. USC. 

8:15 326.2 A link between the processing of object ensembles 

and texture in the parahippocampal place area. J. S. CANT; Y. 

XU*. Harvard Univ. 

8:30 326.3 Object feature integration within 1 mm³ of macaque 

inferior temporal cortex. C. P. HUNG*; C. LIN; Y. CHEN. Natl. 

Yang Ming Univ. 

8:45 326.4 Neural representation of the size of space and 

the amount of clutter in a scene. S. PARK*; T. KONKLE; A. 

OLIVA. MIT. 



9:00 326.5 Receptive field properties in primate visual cortical 

hierarchy from large scale statistics of natural images. L. M. 

BETTENCOURT*; S. BRUMBY; J. GEORGE; M. I. HAM; G. 

KENYON. Los Alamos Nat Lab. 

9:15 326.6 Category-selective visual areas represent 

retinotopic, but not spatiotopic, location information. J. D. 

GOLOMB*; N. KANWISHER. MIT. 

9:30 326.7 Sparse sampling degrades translational invariance 

for smaller stimuli. S. AFRAZ*; P. CAVANAGH. MIT, Lab. 

Psychologie de la Perception, Univ. Paris Descartes, 75006. 

9:45 326.8 Neural construction of scenes from objects in human 

occipitotemporal cortex. S. P. MACEVOY*; R. A. EPSTEIN. 

Boston Col., Univ. of Pennsylvania. 

10:00 326.9 The coding of object interactions in LOC. J. G. KIM*; 

I. BIEDERMAN. USC. 

10:15 326.10 High-level scene representations: Its the spaces not 

the places. D. J. KRAVITZ*; C. S. PENG; C. I. BAKER. NIH, 

Carnegie Mellon Univ. 

10:30 326.11 Trans-saccadic memory for border ownership in 

neurons of the visual cortex. P. J. O’HERRON*; R. VON DER 

HEYDT. Johns Hopkins Univ. 

10:45 326.12 Examining how objects of different real-world sizes 

are represented in ventral visual cortex. T. A. KONKLE*; A. 

OLIVA. MIT. 

11:00 326.13 The representation of objects in inferior temporal 

cortex with and without attention. E. M. MEYERS*; Y. ZHANG; 

N. BICHOT; T. SERRE; T. POGGIO; R. DESIMONE. MIT, 

Brown Univ. 

11:15 326.14 Hole vs. Whole discriminated by early responses of 

anterior temporal brain regions: Timing of holistic processing 

revealed by intracranial recording on human subjects. Z. LIU*; 

R. WU. Inst. Biophysics, CAS, Inst. of Biophysics, CAS. 

NANOSYMPOSIUM 

327. Perception across Movements 



8:00 327.1 How transient “remapping” of neuronal receptive 

fields mediates perceptual stability. M. MORRONE*; G. 

CICCHINI; P. BINDA; D. BURR. Universita’ Di Pisa, IRCCS 

Stella Maris, Univ. Vita-Salute S Raffaele, Univ. of Florence, 

CNR - Inst. of Neurosci. 

8:15 327.2 Temporal uncertainty as the cause of spatial 

mislocalization. J. B. SMEETS*; F. MAIJ; R. J. VAN BEERS; 

E. BRENNER. Human Movement Sciences, VU Univ. 

8:30 327.3 An explanation of perisaccadic flash mislocalization 

when the flash occurs together with background stimuli. J. R. 

POLA*. SUNY Col. Optometry. 

8:45 327.4 Motion reveals imperfect spatial constancy for 

head tilt compared to head translation. P. CAVANAGH*; 

D. WHITNEY; M. SZINTE. Univ. Paris Descartes, Univ. of 

California, Berkeley. 

9:00 327.5 Perception of spatiotemporal events across 

saccades. D. MELCHER*; N. DE PISAPIA; L. KAUNITZ; A. 

FRACASSO. Univ. of Trento. 

9:15 327.6 Misjudging where you felt a light switch in a dark 

room. F. MAIJ*; D. D. J. DE GRAVE; E. BRENNER; J. B. J. 

SMEETS. VU Univ. Amsterdam. 



9:30 327.7 On the illusory perceptual compression of visual 

space during eye-head gaze saccades. D. GUITTON*; A. 

RICHARD; C. PACK. McGill Univ. 

NANOSYMPOSIUM 

328. Relational Memory 

Theme F: Cognition and Behavior 


8:00 328.1 The Source of the Associative Deficit in Aging: 

fMRI evidence of the effect of reduced attentional resources 

for relational processing. S. KIM*; K. GIOVANELLO. Univ. of 

North Carolina - Chapel Hill. 

8:15 328.2 Effects of aging on the neural basis of implicit 

associative memory. I. T. DEW*; K. S. GIOVANELLO. Univ. 

of North Carolina At Chapel Hill, Univ. of North Carolina at 

Chapel Hill. 

8:30 328.3 Spontaneous relational behaviors: Linking action, 

memory, and the hippocampus. J. L. VOSS*; D. E. WARREN; 

D. TRANEL; N. J. COHEN. Beckman Inst., Univ. of Iowa. 

8:45 328.4 The effects of prediction strength on associative 

novelty signals in human CA1 and medial temporal lobe 

cortex: A high-resolution fMRI study. J. CHEN*; A. D. 

WAGNER. Stanford Univ. 

9:00 328.5 Medial temporal lobe contributions to encoding 

novel cross modal associations: An examination of temporal 

discontinuity. J. D. KOEN*; A. P. YONELINAS; C. M. PARKS; 

M. ALY; C. RANGANATH. Univ. of California, Davis, Univ. of 

Nevada Las Vegas. 

9:15 328.6 Encoding item, context, and relational information: 

fMRI adaptation in the medial temporal lobes. R. A. DIANA*; 

A. YONELINAS; C. RANGANATH. Univ. of California, Davis. 

9:30 328.7 Persistence of patterns of activity across 

hippocampal voxels during post-encoding awake rest. A. 

TAMBINI*; L. DAVACHI. New York Univ. 

9:45 328.8 Multivoxel pattern analysis of cross-episode 

binding: Reactivation of prior episodic experience during 

learning supports flexible memory. D. ZEITHAMOVA*; A. R. 

PRESTON. Univ. Texas, Austin. 

10:00 328.9 The effects of emotion and encoding strategy on 

associative memory. B. D. MURRAY; E. A. KENSINGER*. 

Boston Col. 

10:15 328.10 Assessing the multidimensional features of memory 

uncovers selective impairment for relational information in 

patients with hippocampal damage. P. D. WATSON*; J. L. 

VOSS; D. E. WARREN; D. T. TRANEL; N. J. COHEN. Univ. of 

Illinois at Urbana-Champaign, Univ. of Iowa. 



NANOSYMPOSIUM 

NANOSYMPOSIUM 

329. Neural Bases of Negative Emotional States 


Mon. 8:00 AM — San Diego Convention Center, Room 2 

8:00 329.1 A central amygdala neural circuitry controls fear 

behavior. H. CAI*; W. HAUBENSAK; P. KUNWAR; D. J. 

ANDERSON. Caltech. 

8:15 329.2 Can we share pain we always feel ? Neural 

correlates of empathy and pain in patients with painpredominant 

multisomatoform disorder. M. NOLL- 

HUSSONG*; A. OTTI; L. LÄER; A. WOHLSCHLAEGER; 

C. ZIMMER; J. DECETY; P. HENNINGSEN; R. D. LANE; 

H. GÜNDEL. Klinik fuer Psychosomatische Medizin des 

Klinikums rechts der Isar, Technische Univ. Muenchen, Univ. 

of Chicago, Univ. of Arizona, Univ. Ulm. 

8:30 329.3 Maternal high-fat diet consumption suppresses 

serotonergic system signaling in juvenile nonhuman primate 

offspring resulting in increased anxiety and anti-social 

behavior. E. L. SULLIVAN*; K. COLEMAN; K. L. GROVE. 

Oregon Hlth. and Sci. Univ. 

8:45 329.4 Neonatal lesions to the rhesus macaque amygdala 

result in blunted adult affect. E. BLISS-MOREAU*; J. E. 

TOSCANO; M. D. BAUMAN; D. G. AMARAL. Univ. California, 

Davis, California Natl. Primate Res. Ctr., The M.I.N.D. Inst., 

Ctr. for Neurosci. 

9:00 329.5 Neural processing of dynamic facial expressions in 

humans and monkeys: A comparative fMRI study. Q. ZHU*; 

K. NELISSEN; J. VAN DEN STOCK; B. DE GELDER; H. 

KOLSTER; W. VANDUFFEL; M. VANDENBULCKE. Lab. 

For Neuro- and Psychofysiology, K.U. Leuven, Dept. of 

Radiology, MGH, Div. of Psychiatry, K.U.Leuven, Lab. - Dept. 

of psychonomics, Tilburg Univ. 

9:15 329.6 Anxiety impairs decision-making in rats through 

differential recruitment of cortico-limbic circuits. L. DE 

VISSER*; J. M. BAARS; M. LAVRIJSEN; C. M. M. VAN DER 

WEERD; L. J. VAN DER KNAAP; R. VAN DEN BOS. Utrecht 

Univ. 

9:30 329.7 • Integrative neuroscience: Genes, environment and 

the emotional brain. L. M. WILLIAMS*; S. H. KOSLOW; J. M. 

GATT; P. R. SCHOFIELD; E. GORDON. Univ. of Sydney Med. 

Sch., BRAINnet Fndn., Prince of Wales Med. Res. Inst., Brain 

Resource. 

9:45 329.8 Insula and striatum mediate the default bias. R. YU*; 

D. MOBBS; B. SEYMOUR; A. J. CALDER. MRC Cognition 

and Brain Sci. Unit, Univ. Col. London. 

10:00 329.9 Different pathways in medial prefrontal cortex predict 

effective spontaneous emotion regulation. J. SILVERS*; T. D. 

WAGER; J. WEBER; K. N. OCHSNER. Columbia Univ., Univ. 

of Colorado. 

10:15 329.10 Differential neural and behavioral coupling of fear 

and happiness. M. JABBI*; T. NASH; P. KOHN; A. IANNI; T. 

HOLROYD; F. CARVER; Q. CHEN; J. S. KIPPENHAN; R. 

COPPOLA; K. F. BERMAN. Natl. Inst. of Mental Health, NIH, 

NIMH. 

10:30 329.11 Kappa opioid receptor agonism reduces activity 

but increases sucrose consumption: A mouse model of the 

acute role of dynorphin in depression. M. R. ZELLNER*; J. 

PANKSEPP; C. FONTAINE; D. W. PFAFF. Rockefeller Univ., 

Washington State Univ. 


POSTER 

330. Postnatal Neurogenesis II 


Mon. 8:00 AM — San Diego Convention Center, Halls B-H 

8:00 A1 330.1 Investigating the roles of purinergic 

signaling in adult neurogenesis. S. SUYAMA*; T. SUNABORI; 

H. OKANO. Keio University, Sch. of Med. 

9:00 A2 330.2 Hippocampal neurogenesis mediates 

cognitive recovery following brain injury. C. A. BLAISS*; T. YU; 

G. ZHANG; J. CHEN; G. DIMCHEV; L. F. PARADA; C. M. 

POWELL; S. G. KERNIE. UT Southwestern Med. Ctr. 

10:00 A3 330.3 Impaired terminal differentiation of 

hippocampal granule neurons and defective contextual 

memory in PC3/Tis21 knockout mice. S. FARIOLI- 

VECCHIOLI; D. SARAULLI; M. COSTANZI; L. LEONARDI; 

I. CINÀ; L. MICHELI; M. NUTINI; P. LONGONE; P. OH; V. 

CESTARI; F. TIRONE*. Inst. di Neurobiologia e Medicina 

Molecolare, Inst. di Neuroscienze, Mol. Neurobio. Unit, 

Fondazione S.Lucia, Dept. of Physiol. and Functional 

Genomics, Univ. of Florida, LUMSA Univ. 

11:00 A4 330.4 Effects of LTP and LTD induction on cell 

survival in the hippocampal dentate gyrus of adult rats. T. 

KITAMURA*; Y. SAITOH; A. MURAYAMA; H. SUGIYAMA; K. 

INOKUCHI. Univ. of Toyama, Mitsubishi Kagaku Inst. of Life 

Sciences, MITILS, Japan Sci. and Technol. Agency, CREST, 

Kyushu Univ. 

8:00 A5 330.5 Mbd1 and mir-184 molecular network 

governs neural stem cell proliferation and differentiation. C. 

LIU*; Z. TENG; C. FLITCROFT; K. SZULWACH; P. JIN; X. 

ZHAO. Univ. of New Mexico, Emory Univ. Sch. of Med. 

9:00 A6 330.6 Experience specific information encoding 

by newborn neurons of the adult dentate gyrus. G. D. 

CLEMENSON*, JR; F. H. GAGE. Salk Inst. 

10:00 A7 330.7 Visual experience modulates postnatal 

retinal neurogenesis during critical period in postnatal 

development. A. V. TKATCHENKO*; S. I. TOMAREV; G. N. 

ENIKOLOPOV; T. V. TKATCHENKO. Wayne State Univ., Natl. 

Eye Inst., Cold Spring Harbor Lab. 

11:00 A8 330.8 NF-kappaB proteins as critical regulators 

of adult neurogenesis. V. BORTOLOTTO; M. T. FRANCESE; 

A. DELLAROLE; M. ORSETTI; P. GHI; M. M. VALENTE; C. 

CROSTA; P. L. CANONICO; S. DENIS-DONINI; M. GRILLI*. 

Lab. of Neuroplasticity & Pain, Discaff & DFB Center, Un. 

Piemonte Orientale, Univ. of Torino, CNR. 

8:00 A9 330.9 Spine formation pattern of new neurons is 

differentially modulated by the timing of LTP induction in adult 

dentate gyrus. N. OHKAWA*; Y. SAITOH; E. TOKUNAGA; F. 

OZAWA; A. MURAYAMA; T. KITAMURA; K. INOKUCHI. Dept. 

of Biochem., Univ. of Toyama Grad. Sch. of Med. and Pharm., 

Mitsubishi Kagaku Inst. of Life Sci., MITILS, JST, CREST, Inst. 

of Med. Sci., Univ. of Tokyo. 

9:00 A10 330.10 Human alpha-synuclein interferes with 

dendrite and spine development of newborn neurons. 

M. REGENSBURGER*; B. WINNER; L. BOYER; S. 

SCHREGLMANN; E. ROCKENSTEIN; E. MASLIAH; J. 

WINKLER; F. H. GAGE. The Salk Inst. For Biol. Studies, Dept. 

of Neurosciences, UCSD, Div. of Mol. Neurology, Univ. Hosp. 

Erlangen. 

10:00 B1 330.11 Synaptic GABA input to newborn 

neurons is mediated by a distinct interneuron subtype. 

S. J. MARKWARDT*; J. I. WADICHE; L. OVERSTREET 

WADICHE. Univ. of Alabama Birmingham. 



11:00 B2 330.12 Paradoxical increase of hippocampal 

neurogenesis in serotonin deficient mice. S. K. 

TROWBRIDGE; N. NARBOUX-NEME; S. L. DIAZ; 

S. JESSBERGER; E. S. DENERIS; P. GASPAR*. 

INSERM-U839, Inst. of Cell Biol., Case Western Reserve 

Univ. 

8:00 B3 330.13 • The effects of dopamine on hippocampal 

neurogenesis in a transgenic mouse model of Huntington’s 

disease. M. CHOI*; P. TYERS; C. D. CLELLAND; L. M. 

SAKSIDA; T. J. BUSSEY; F. H. GAGE; R. A. BARKER. 

Cambridge Ctr. For Brain Repair Ctr., Dept. of Psychology, 

Lab. of Genetics,. 

9:00 B4 330.14 Neuropeptide VGF induces neural 

progenitor cell proliferation in an activity-dependent manner. 

S. THAKKER-VARIA; D. DOOBIN; J. ALDER*. UMDNJ - 

Robert Wood Johnson Med. Sch. 

10:00 B5 330.15 • In vivo fate mapping and expression 

signature of prospectively isolated adult neural 

stem cells from the mouse subependymal zone. R. 

BECKERVORDERSANDFORTH; P. TRIPATHI; J. NINKOVIC; 

L. DIMOU*; E. BAYAM; A. LEPIER; F. KIRCHHOFF; J. 

HIRRLINGER; J. BECKERS; M. IRMLER; M. GÖTZ. 

Helmholtz Ctr. Munich, Inst. of Physiol., Univ. of Munich, Max 

Planck Inst. of Exptl. Med., Univ. of Leipzig. 

11:00 B6 330.16 Cytoskeleton linker proteins involved in 

neuroblast migration in the adult rostral migratory stream. 

Å. PERSSON*; C. LINDWALL; M. CURTIS; G. KUHN. 

Gothenburg University/Institute for Neurosci. and Physiology/ 

CBR, The Univ. of Auckland. 

8:00 B7 330.17 The role of BMP signaling in adult 

hippocampal neurogenesis. A. M. BOND*; K. T. GOBESKE; J. 

F. DISTERHOFT; J. A. KESSLER. Northwestern University’s 

Feinberg Sch. of Med. 

9:00 B8 330.18 Early apoptosis during neurogenesis in the 

adult mouse hippocampus. J. J. DEUDERO; A. SIERRA; J. M. 

ENCINAS; J. H. CHANCEY; L. S. OVERSTREET-WADICHE; 

G. ENIKOLOPOV; S. E. TSIRKA; M. MALETIC-SAVATIC*. 

Baylor Col. of Med., Univ. of Alabama at Birmingham, Cold 

Spring Harbor Lab., Stony Brook Univ. 

10:00 B9 330.19 Nfatc4 is required for the generation of 

new neurons and new memories in the adult hippocampus. 

G. QUADRATO*; C. JACOB; M. BENEVENTO; R. LINDNER; 

T. NGUYEN; S. DI GIOVANNI. Hertie Inst. for Clin. Brain 

Research, Univ. of Tuebingen. 

11:00 B10 330.20 Impaired environmental enrichmentinduced 

adult hippocampal neural progenitor proliferation 

in FAD-linked human PS1M146V knock-in mice. K. 

VEERARAGHAVALU*; K. EIPL; S. SISODIA. Univ. Chicago. 

8:00 B11 330.21 Age-related changes in systemic 

chemokine levels regulate adult neurogenesis. S. A. 

VILLEDA*; J. LUO; M. BRITSCHGI; T. STAN; Z. DING; S. 

COUILLARD-DESPRÉS; L. AIGNER; T. RANDO; T. WYSS- 

CORAY. Stanford Univ., Neurosci. IDP Program, F. Hoffmann- 

La Roche Ltd., Immunolgy IDP Program, Paracelsus Med. 

Univ., VA Palo Alto Hlth. Care Syst. 

9:00 B12 330.22 Environmental enrichment enhances 

synaptic input to newborn neurons during their critical period. 

J. H. CHANCEY; M. SAPP; P. C. PUGH; J. I. WADICHE; L. S. 

OVERSTREET WADICHE*. Univ. Alabama Birmingham. 

10:00 B13 330.23 • Neurogenesis contributes to tolerance 

to modeled ischemia in arctic ground squirrel neuronal 

progenitor cells. K. L. DREW*; M. S. WELLS; R. C. MCGEE; 

A. P. ROSS; J. A. KELLEHER-ANDERSSON. Univ. Alaska, 

Neuronascent, Inc., Lifeline Cell Technologies. 



11:00 B14 330.24 • Novel small molecule inhibitors of KMT7, 

a lysine mono-methyl transferase. C. L. BENN*; M. BICTASH; 

H. BOYD; M. E. BUNNAGE; D. CARTER; P. CHOUDHARY; 

A. COOK; P. V. FISH; J. E. J. MILLS; A. PANNIFER; C. 

PHILLIPS; K. SKINNER; C. WALDEN. Pfizer Inc. 

POSTER 

331. human ESCs and iPSCs 



8:00 B15 331.1 Transplantation of human iPS derived 

dopaminergic neurons to a primate model for Parkinson 

disease. T. KIKUCHI*; A. MORIZANE; D. DOI; H. ONOE; 

T. HAYASHI; T. KAWASAKI; J. TAKAHASHI. Inst. Frontier 

Med. Sciences, Kyoto Univ., Dept. of Cell Growth and 

Differentiation, Ctr. iPS Cell Res. and Application, Kyoto 

Univ., Functional Probe Res. Laboratory, RIKEN Ctr. for Mol. 

Imaging Sci. 

9:00 B16 331.2 Paracrine signals restrict neuronal 

migration from human neural progenitor cell containing grafts. 

J. LADEWIG*; P. KOCH; O. BRÜSTLE. Univ. of Bonn and 

Hertie Fndtn. 

10:00 B17 331.3 Modulation of dorsomorphin and oxygen 

in adherent neural differentiation of human pluripotent stem 

cells. D. DRURY-STEWART*; O. MOHAMAD; S. P. YU; L. 

WEI. Emory Univ. 

11:00 B18 331.4 Human embryonic stem cell-derived 

neurons modulate the excitability of a pre-existing neural 

network. J. P. WEICK*; S. ZHANG. Univ. of Wisconsin. 

8:00 B19 331.5 Functional cholinergic neurons from 

human embryonic stem cells. Y. LIU*; R. KRENCIK; H. LIU; 

L. MA; X. ZHANG; S. ZHANG. Waisman Center, Univ. of 

Wisconsin, Dept of Anat. and Histology., Inst. of Stem Cells 

and Regenerative Medicine, Fudan Univ., Dept. of Anat, Univ. 

of Wisconsin, Dept of Neurol, Univ. of Wisconsin. 

9:00 B20 331.6 Genetically labeled human embryonic 

stem cells transplanted in human slice cultures. G. E. 

REINCHISI; C. CAI; N. R. ZECEVIC*. Univ. Connecticut Hlth. 

Ctr. 

10:00 B21 331.7 Specification of functional striatal 

GABAergic projection neurons from human stem cells. L. 

MA; B. HU*; Y. LIU; S. C. VERMILYEA; H. LIU; X. ZHANG; Y. 

SUN; L. GAO; J. LI; M. AYALA; S. ZHANG. Fudan Univ., Univ. 

of Wisconsin-Madison. 

11:00 B22 331.8 • Suppression of reactive oxygen species 

enhances the differentiation of human induced pluripotent 

stem cells into neuronal precursor cells. A. JI; Y. JANG; J. 

HYUN*. Dankook Univ., Dankook Univ. Col. of Med. 

8:00 B23 331.9 Efficient production of neural progenitors 

from human pluripotent stem cells (hESC and iPSC) in 

AggreWell TM 400 and AggreWell TM 800 in a novel neural 

induction medium. A. A. BLAK*; J. ANTONCHUK; E. 

YOSHIDA; T. E. THOMAS; A. C. EAVES; S. A. LOUIS. 

STEMCELL Technologies Inc., BC Cancer Res. Ctr. 

9:00 B24 331.10 Molecular effects of Lmx1a overexpression 

in differentiating human embryonic stem cells. M. P. 

PARMAR*; A. KIRKEBY; R. SACHDEVA; J. JAKOBSSON; A. 

BJÖRKLUND. Wallenberg Neurosci Ctr. 


Mon. AM

10:00 B25 331.11 Sorting and transplantation of neural 

progenitor cells derived from human pluripotent stem cells. 

D. DOI*; T. KIKUCHI; A. MORIZANE; J. TAKAHASHI. Ctr. 

For iPS Cell Res. and Application, Kyoto Univeisity, Inst. for 

Frontier Med. Sciences, Kyoto Univ. 

11:00 B26 331.12 Protein tagging in human pluripotent 

stem cell-derived neural stem cells. J. M. DOERR*; J. 

SCHMIDT; I. POSER; A. A. HYMAN; P. KOCH; O. BRÜSTLE. 

Reconstructive Neurobiologie, Max Planck Inst. for Mol. Cell 

Biol. and Genet. 

8:00 B27 331.13 • Generation of nociceptive neurons from 

mouse and human embryonic stem cells. L. KATSIMPARDI*; 

N. TSUJIMOTO; B. BISCARO; Q. MA; J. SCHOLZ; C. 

BRENNEIS; B. WAINGER; C. J. WOOLF; L. L. RUBIN. 

Harvard Univ., Dana-Farber Cancer Inst. and Harvard Med. 

Sch., Massachusetts Gen. Hosp. and Harvard Med. Sch. 

9:00 B28 331.14 Induction of an inner ear fate in human 

embryonic and induced pluripotent stem cells. E. L. 

MCMILLAN*; A. L. FOATE; C. L. CHOW; D. P. BRUNNER; 

S. ZHANG; S. P. GUBBELS. Univ. of Wisconsin, Univ. of 

Wisconsin. 

10:00 C1 331.15 Glial cell-line derived neurotrophic 

factor and the mechanisms for dopaminergic development 

in embryonic stem cell derived neural progenitor cells. A. 

YOUNG*; F. D. WEST; K. ASSEY; S. L. STICE. Univ. of 

Georgia. 

11:00 C2 331.16 Excitation of sca3 ips cell-derived neurons 

induces calpain-mediated ataxin-3 cleavage and aggregation. 

P. KOCH*; P. BREUER; J. JUNGVERDORBEN; M. PEITZ; D. 

POPPE; J. DOERR; J. LADEWIG; B. EVERT; U. WÜLLNER; 

T. KLOCKGETHER; O. BRÜSTLE. Univ. Bonn, Life&Brain 

Bldg, Life&Brain GmbH, Univ. of Bonn. 

8:00 C3 331.17 Neural differentiation induced by retinoic 

acid is followed by aneuploidy in pluripotent stem cells. S. 

K. REHEN*; R. SARTORE; P. CAMPOS; B. PAULSEN; B. 

RAMALHO; C. TRUJILLO; P. NEGRAES; H. ULRICH; L. 

CHICAYBAM; M. BONAMINO. Natl. Lab. For Embryonic Stem 

Cell Research, UFRJ, USP, Natl. Cancer Inst. 

9:00 C4 331.18 Effects of inflammation mediating 

cytokines in multiple sclerosis to viability and functionality 

human neural stem/progenitor cells. S. H. NARKILAHTI*; 

S. RINTA; A. MÄKINEN; R. SUURONEN; H. SKOTTMAN; 

I. ELOVAARA. Regea, Inst. Regenerat Med,Univ.Tampere, 

Neuroimmunology Unit, Med. School, Univ. of Tampere and 

Tampere Univ. Hosp., Dept. of Eye, Ear, and Oral Diseases, 

Tampere Univ. Hosp., Dept. of Biomed. Engineering,Tampere 

Univ. of Technol., Dept. of Neurology, Tampere Univ. Hosp. 

10:00 C5 331.19 Neural stem cells derived from human 

pluripotent stem cells exhibit preferential neuroprotection 

against ischemia via a unique secretome pattern. I. LEE*; 

K. LIAO; C. CHUANG; S. HUANG; J. HSIEH; H. LIN; C. 

CHUANG; O. LEE; H. KUO; H. WANG. Taipei Veterans Gen. 

Hosp., Natl. Yang-Ming Univ., Academia Sinica, Chung-Shan 

Med. Univ. 

11:00 C6 331.20 Derivation of Parkinson’s disease patient 

specific induced pluripotent stem cells (iPSCs). F. YANG; X. 

TENG; R. C. BAEK*; Z. ZHANG. Sanford-Burnham Med. Res. 

Inst. 

8:00 C7 331.21 Neural differentiated induced pluripotent 

stem cells derived from autopsy donors: Comparing in vitro 

and in vivo cells by RNA-Seq. B. E. HJELM*; L. I. SUE; T. G. 

BEACH; J. J. CORNEVEAUX; K. R. VAN KEUREN-JENSEN; 

M. J. HUENTELMAN; D. W. CRAIG. The Translational 

Genomics Res. Inst., Arizona Alzheimer’s Consortium, 

Arizona State Univ., Banner Sun Hlth. Res. Inst. 

POSTER 

332. Axon Guidance: Cellular and Organismal Mechanisms 



8:00 C8 332.1 miRNA-338 coordinately regulates the 

intra-axonal expression of multiple mRNAs encoding subunits 

of the oxidative phosphorylation machinery. O. NATERA- 

NARANJO; A. ASCHRAFI; A. KAR; A. E. GIOIO*; B. B. 

KAPLAN. NIMH, NIH, NIMH-HBP (neuroinformatics). 

9:00 C9 332.2 Withdrawn 

10:00 C10 332.3 AMP-activated protein kinase regulates 

neuronal polarization by interfering with the localization of 

PI3-kinase. S. P. AMATO*; B. ZHENG; X. LIU; L. CANTLEY; 

P. RAKIC; H. MAN. Boston Univ., Harvard Med. School, Dana 

Farber Cancer Inst., Yale Univ. Sch. of Medicine, Kavli Inst. for 

Neurosci. 

11:00 C11 332.4 Neuronal activity-dependent mitochondrial 

redistribution regulates axonal morphogenesis. K. TAO*; N. 

MATSUKI; R. KOYAMA. The Univ. of Tokyo. 

8:00 C12 332.5 The stargazin-related protein Γ7 interacts 

with β-actin mRNA to regulate neurite outgrowth. L. P. 

FERRON*; D. WAITHE; A. C. DOLPHIN. UCL. 

9:00 C13 332.6 Rho isoform-selective modulation 

of cortical neuron development. E. LORENZETTO; M. 

ETTORRE; M. BOLOMINI-VITTORI; A. MONTRESOR; C. 

LAUDANNA; M. BUFFELLI*. Univ. of Verona, Univ. of Verona. 

10:00 C14 332.7 Neurotrophin and doublecortin 

(DCX) promote neurofascin accumulation at the axonal 

initial segment. C. YAP*; M. VAKULENKO; J. S. LIU; B. 

WINCKLER. Univ. Virginia, Ctr. for Neurosci. Research, 

Children ‘s Natl. Med. Ctr. 

11:00 C15 332.8 Single-organelle analysis of synaptic 

vesicle protein axonal transport carrier-motor complexes. A. E. 

SGRO*; S. M. BAJJALIEH; D. T. CHIU. Univ. of Washington. 

8:00 C16 332.9 RET51-EGFP mice: A valuable tool for 

investigating trafficking of the RET tyrosine kinase in living 

cells and tissues. K. ITO*; H. ENOMOTO. RIKEN CDB. 

9:00 C17 332.10 Role of Synaptobrevin2 in Sema3amediated 

axonal repulsion and collapse. K. ZYLBERSZTEJN; 

M. PETKOVIC; S. MARCOS; A. BURGO; E. BLOCH- 

GALLEGO; F. NOTHIAS; D. BAGNARD; T. BINZ; T. GALLI*. 

Jacques Monod Inst., Cochin Inst., Pierre et Marie Curie Univ., 

Neurochimie Ctr., Inst. für Biochemie. 

10:00 C18 332.11 From wiring to behavior: The life and times 

of a connectivity mutant. G. NEWQUIST; M. KIM*; T. KIDD. 

Univ. of Nevada, Reno. 

11:00 C19 332.12 Expression and function of Nel in 

visual system development. C. NAKAMOTO; S. KUAN; M. 

NAKAMOTO*. Sch. of Med. Sci, Univ. of Aberdeen. 

8:00 C20 332.13 UNC-80 and the putative cation channel 

NCA-1 regulate axon guidance and outgrowth. H. LI*; W. 

WADSWORTH. UMDNJ, Robert Wood Johnson Me, UMDNJ- 

Robert Wood Johnson Med. Sch. 

9:00 C21 332.14 Effects of extremely low electromagnetic 

fields on neuritogenesis: Limits of in vitro studies. S. 

SACCHETTI*; S. GUARNIERI; C. MORABITO; G. FANO’; M. 

A. MARIGGIO’. Univ. “G. D’Annunzio” Chieti-Pescara. 



10:00 C22 332.15 Abnormal NF-kB activity and associated 

impairments in axonal outgrowth in sensory neurons isolated 

from diabetic rats are corrected by cytokines. A. SALEH; 

S. BALAKRISHNAN; E. MUTCH; R. VAN DER PLOEG; E. 

AKUDE; D. R. SMITH; P. FERNYHOUGH*. St Boniface Res. 

Ctr., Univ. of Manitoba. 

POSTER 

333. Axon Development and Polarity 



8:00 C23 333.1 The role of Satb2/Ctip2 and Fezl in 

cortical connectivity and the elucidation of their downstream 

pathways. P. SGOURDOU*; S. PARTHASARATHY; O. 

BRITANOVA; V. TARABYKIN. MPI for experimental medicine, 

Shemiakin and Ovchinnikov Inst. of Bioorganic Chem., MPI 

experimental medicine and Institure of Anat. and Cell Biology, 

Charite, Univ. medical school. 

9:00 C24 333.2 Role of GABA(B) receptors in migration 

and morphological maturation of cortical pyramidal neurons. 

G. BONY*; A. CONTESTABILE; L. CANCEDDA. DIST - Univ. 

of Genova, Italian Inst. of Technol. 

10:00 C25 333.3 ApoER2 function in the establishment 

and maintenance of retinal synaptic connectivity. J. H. 

TROTTER*; M. KLEIN; D. BIRCH; J. HERZ; E. WEEBER. 

Byrd Alzheimer’s Ctr., Retina Fndn. of the Southwest, Univ. 

of Texas Southwestern Med. Ctr., USF Hlth. Byrd Alzheimer’s 

Inst. 

11:00 C26 333.4 Inhibition of axon outgrowth in sympathetic 

neurons by infarcted myocardium. R. GARDNER*; B. A. 

HABECKER. Oregon Hlth. and Sci. Univ. 

8:00 C27 333.5 A minimal model of retinotectal map 

development can unify a broad range of experimental 

phenomena. H. D. SIMPSON*; G. J. GOODHILL. Queensland 

Brain Institute, The Univ. of Queensland. 

9:00 C28 333.6 Nedd9 (HEF-1) is required for cranial 

nerve development and blood pressure regulation. D. C. 

KNUTSON; E. M. MCNEILL*; K. P. ROOS; M. CLAGETT- 

DAME. Univ. of Wisconsin, David Geffen Sch. of Med. UCLA. 

10:00 C29 333.7 Evidence for a role of specific diencephalic 

cell populations on delayed interstitial axonal branching by the 

principal mammillary tract. N. SZABÓ; T. ZHAO; X. ZHOU; G. 

ALVAREZ-BOLADO*. IRCM, UC Davis, Univ. of Heidelberg, 

Anatomisches Institut-Tubingen Univ. 

11:00 C30 333.8 Developmental changes in cardiac 

neurturin expression and cholinergic innervation of the heart. 

D. B. HOOVER*; E. A. JACKSON, Jr.; H. L. SHEPHERD; A. 

A. PATEL; M. M. DUFFOURC. East Tennessee State Univ. 

8:00 C31 333.9 Overexpression of the mRNA-destabilizing 

RNA-binding protein KSRP or one of its KH domains inhibits 

neuronal differentiation. C. W. BIRD*; N. I. PERRONE- 

BIZZOZERO. Univ. New Mexico Med. S. 

9:00 C32 333.10 Pitch-dependant acceleration of neurite 

development on anodized aluminum oxide-nanostructured 

substrates. Y. NAM*; K. KANG; W. K. CHO; G. KANG; M. J. 

JANG; I. S. CHOI. KAIST. 

10:00 C33 333.11 The role of Notch signaling in the 

development of hypothalamic neurons. P. K. AUJLA*; A. 

BORA; J. V. SWEEDLER; L. T. RAETZMAN. Univ. of Illinois. 



11:00 C34 333.12 Effects of the maternally derived survival 

promoting peptide Y-P30 on the developing rat brain. J. R. 

NEUMANN*; S. WIESE; P. WAHLE. Ruhr Univ. Bochum. 

8:00 C35 333.13 A transient placental source of serotonin 

for the fetal forebrain. A. BONNIN*; N. GOEDEN; J. C. 

SHIH; R. D. BLAKELY; E. DENERIS; P. LEVITT. USC - ZNI, 

Vanderbilt Univ., Case Western Reserve Univ. 

9:00 C36 333.14 Axonal transport and local translation of 

odorant receptor mRNAs in olfactory sensory neurons of Fmr1 

KO mice. C. DUBACQ*; J. CHAREYRE; A. TREMBLEAU. 

UPMC CNRS UMR7102, INSERM AVENIR. 

10:00 C37 333.15 Vasoinhibins antagonize the neurotrophic 

effect of VEGF and NGF in neurons from the dorsal root 

ganglion of newborn rats. X. CASTILLO*; E. TAMARIZ; A. 

VARELA-ECHAVARRÍA; C. CLAPP; G. MARTÍNEZ DE LA 

ESCALERA. Univ. Nacional Autonoma de Mexico (UNAM). 

11:00 C38 333.16 Characterization of CDK12 and CDK13 

functions in neurite outgrowth. H. CHEN*; C. CHENG; G. LIN; 

Y. HONG; M. FANN. Dept. of Life Sci. and Inst. of Genome 

Sciences, Natl. Yang-Ming, Inst. of Neuroscience, Natl. Yang- 

Ming Univ. 

8:00 D1 333.17 Local p75NTR expression is predictive 

of the specification of axons during neuronal polarization. M. 

BERGAMI*; E. ZUCCARO; B. VIGNOLI; L. CANCEDDA; M. 

CANOSSA. Italian Inst. of Technol. 

9:00 D2 333.18 Distal axonal cytoskeletons drive 

assembly of the axon initial segment. M. GALIANO; S. JHA*; 

T. HO; M. N. RASBAND. Baylor Col. of Med. 

10:00 D3 333.19 The formation of the axon initial segment 

and polarity in developing neurons. T. HO*; M. N. RASBAND. 

Baylor Col. of Med. 

11:00 D4 333.20 The role of actin in the development 

of dendrite and axon phenotypes. G. R. STERNE; G. S. 

WITHERS*. Whitman Col. 

8:00 D5 333.21 The role of B23 in establishment of 

neuronal polarity. I. KWON*; K. LEE; J. AHN. Sungkyunkwan 

Univ. Sch. of Med., Ctr. for Mol. Medicine, Samsung Biomed. 

Res. Inst. 

9:00 D6 333.22 Semaphorin3A signal through Ca V 2.3 

channels to switch axon to dendrite. M. NISHIYAMA; K. 

TOGASHI; M. J. VON SCHIMMELMANN; S. MAEDA; S. 

ISHII; K. HONG*. New York Univ. Sch. Med., Kyoto Univ. 

POSTER 

334. Neuronal Cell Death I 



8:00 D7 334.1 • Anesthesia-induced neonatal brain injury: 

is temperature a factor? C. P. TURNER*; S. GUTIERREZ; C. 

LIU; A. CARNES; E. FINUCANE; W. OELSNER; G. MUSCI. 

Wake Forest Univ. Med. Sch. 

9:00 D8 334.2 Ketamine induces neurotoxicity in 

zebrafish in vivo. J. KANUNGO*; C. WANG; M. G. PAULE. 

Natl. Ctr. For Toxicological Research/Food and Drug Admin. 

10:00 D9 334.3 Unbiased analysis of trigeminal cell 

number in rodents with assessment of p75 receptor mutations 

and NGF over-expression in smooth muscle cells. S. A. 

SCOTT*; R. E. ATKIN; A. R. COFFMAN; M. C. DONOGHUE; 

L. G. KUCHTA; K. M. STUART; P. V. YONTZ; M. D. KAWAJA. 

Ohio Univ., Queen’s Univ. 


Mon. AM

11:00 D10 334.4 NF-Y is essential for expression of the 

proapoptotic bim gene in neurons. J. HAM*; R. HUGHES; 

M. KRISTIANSEN; R. MANTOVANI. UCL Inst. of Child Hlth., 

Univ. degli Studi di Milano. 

8:00 D11 334.5 Ketamine anesthesia during the first 

week of life can cause long-lasting cognitive deficits in rhesus 

monkeys. M. G. PAULE*; M. LI; X. ZOU; C. HOTCHKISS; J. 

P. HANIG; T. A. PATTERSON; W. SLIKKER, Jr.; C. WANG. 

Natl. Ctr. Toxicological Res., Bionetics Corp., Ctr. for Drug 

Evaluation and Res. 

9:00 D12 334.6 Cell specific ablation of pten signaling 

alters gabaergic circuitry. G. N. BARNES*; Y. LI. Vanderbilt 

Univ. Sch. Med. 

10:00 D13 334.7 GABA toxicity in immature Purkinje cells is 

prevented by the steroid mifepristone. J. RAKOTOMAMONJY; 

C. LEVENES; M. M. SCHUMACHER*; A. GHOUMARI. 

INSERM UMR788, UMR8119 CNRS-INC-Université Paris 

Decartes. 

POSTER 

335. Visual Development: Retina, LGN, V1 



8:00 D14 335.1 • The crumbs apicobasal polarity proteins 

are required for photoreceptor stability and functions in the 

zebrafish retina. X. WEI*. Univ. Pittsburgh. 

9:00 D15 335.2 Epigenetic changes at gene promoters 

during mouse rod photoreceptor development. C. J. 

BARNSTABLE*; E. POPOVA; S. S. M. ZHANG. Penn State 

Coll Med. 

10:00 D16 335.3 Bax-mediated apoptosis generates 

functional mosaic of ipRGCs. D. MCNEILL*; S. CHEN; K. S. 

CHEW; R. KURUVILLA; S. HATTAR. Johns Hopkins Univ. 

11:00 D17 335.4 Changing dynamics of spontaneous 

waves during retinal development: A novel panretinal 

perspective achieved with the Active Pixel Sensor (APS) 

4,096 electrodes array. E. SERNAGOR*; A. MACCIONE; 

M. HENNIG; M. GANDOLFO; S. EGLEN; L. BERDONDINI. 

Newcastle Univ., Italian Inst. of Technol., Univ. of Edinburgh, 

Univ. of Genova, Cambridge Univ. 

8:00 D18 335.5 Mechanisms underlying retinal waves in 

mice lacking β2-containing nAChRs. L. A. KIRKBY*; M. B. 

FELLER. UC Berkeley. 

9:00 D19 335.6 The role of starburst amacrine cells 

in initiating retinal waves. K. J. FORD*; A. L. FÉLIX; M. 

B. FELLER. Univ. California Berkeley, Ecole des Ponts 

ParisTech. 

10:00 D20 335.7 Characterization of genetically 

labeled subsets of direction selective ganglion cells in two 

transgenic mouse lines. M. RIVLIN-ETZION*; W. WEI; A. D. 

HUBERMAN; K. ZHOU; B. A. BARRES; M. B. FELLER. Univ. 

of California, Berkeley, Stanford Univ. Sch. of Med. 

11:00 D21 335.8 Functional analysis of bHLH factor Hes1 

on the mouse retinal development. K. SAKAGAMI*; R. 

KAGEYAMA; X. MU; W. H. KLEIN; X. YANG. UCLA, Jules 

Stein Eye Inst., Kyoto Univ., Univ. at Buffalo, Univ. of Texa, 

M.D. Anderson Cancer Ctr. 

8:00 D22 335.9 Intraocular muscimol injection reversibly 

silences spontaneous retinal activity. A. M. HAMBY*; W. WEI; 

M. B. FELLER. Univ. of California Berkeley. 

9:00 D23 335.10 APB blockade of retinal waves does not 

prevent eye-specific segregation of retinogeniculate afferents. 

J. M. BALLESTEROS*; C. SUN; B. CHAPMAN. Univ. of 

California, Davis. 

10:00 D24 335.11 Control of neonatal retinal ganglion 

cell activity using the photoswitchable potassium channel 

blocker AAQ. S. W. FAILOR*; C. SUN; R. H. KRAMER; B. 

CHAPMAN. Univ. of California, Davis, Univ. of California, 

Berkeley. 

11:00 D25 335.12 The effect of light deprivation on retinal 

ganglion cell morphology depends on developmental stage. 

J. L. COOMBS*; D. A. VAN DER LIST; B. CHAPMAN. Univ. 

California- Davis, Ctr. for Neuroscience, UC Davis. 

8:00 D26 335.13 Morphologies of YFP expressing retinal 

ganglion cells in mice where cholinergic transmission has 

been altered by knockout of the nicotinic acetylcholine 

receptor β2 subunit or by immunotoxin ablation of starburst 

amacrine cells. D. A. VAN DER LIST; J. L. COOMBS; J. M. 

BALLESTEROS; C. SUN*; B. CHAPMAN. Univ. Calif, Davis, 

Univ. of California, Davis. 

9:00 D27 335.14 • G-protein coupling with adenosine A2A 

receptor regulates retinal waves in developing rat retinas. P. 

HUANG*; Y. CHEN; C. WANG. Natl. Taiwan Univ. 

10:00 D28 335.15 Developmentally regulated expression 

of CRMP4 in the interlaminar zones of the lateral geniculate 

nucleus. C. J. FLYNN*; W. M. USREY; J. C. CROWLEY. Dept. 

of Biol. Sciences, Carnegie Mellon Univ., Univ. of California, 

Davis. 

11:00 D29 335.16 Differential expression of VGLUT1 and 

VGLUT2 across early development in the kitten LGN. C. W. 

KILEY*; W. M. USREY. UC Davis. 

8:00 D30 335.17 Spatial-temporal interactions of 

spontaneous retinal activity during eye-specific segregation. 

H. XU*, Sr.; M. FURMAN; M. PICCIOTTO; M. CRAIR. Yale 

University, Sch. of Med. 

9:00 D31 335.18 Timing of corticogeniculate innervation 

in the dorsal lateral geniculate nucleus (dLGN) of the 

mouse relies on retinogeniculate axon innervation. T. A. 

SEABROOK*; R. N. ELDANAF; T. E. KRAHE; M. A. FOX; W. 

GUIDO. Virginia Commonwealth Univ. 

10:00 D32 335.19 Development of relay neurons in the 

dorsal lateral geniculate nucleus (dLGN) of the mouse in 

the absence of retinal innervation. R. N. ELDANAF*; M. 

A. FOX; T. E. KRAHE; E. K. DILGER; W. GUIDO. Virginia 

Commonwealth Univ. 

11:00 D33 335.20 Spontaneous retinal activity shapes 

network dynamics in the developing visual cortex in vivo. F. 

SIEGEL*; C. LOHMANN. Netherlands Inst. For Neurosci., 

Max Planck Inst. Of Neurobio. 

8:00 D34 335.21 Abnormal binocular balance contributes to 

altered OD plasticity in PirB-/- mice. M. DJURISIC*; M. MANN; 

M. HUBENER; C. SHATZ. Bio-X, Stanford Univ., Max Planck 

Inst. of Neurobio. 

9:00 D35 335.22 A conserved switch in sensory 

processing prepares developing neocortex for vision. M. 

T. COLONNESE*; A. KAMINSKA; R. KHAZIPOV. INMED/ 

INERM U901, APHP, Groupe Hospitalier Cochin-Saint Vincent 

de Paul. 

10:00 D36 335.23 Ipsilateral lateral line connections from the 

medulla to the tectum in Xenopus. S. B. UDIN*. SUNY. 



POSTER 

336. Limbic System Development 



8:00 D37 336.1 Genes related to gap junction signaling 

are differentially expressed at embryonic day 18 in the 

rat hippocampal formation. A. L. GROSS*; M. SCHMIDT; 

J. S. BURGDORF; R. A. KROES; J. R. MOSKAL; B. J. 

CLAIBORNE. Univ. New Mexico, Northwestern Univ. 

9:00 D38 336.2 N-methyl-D-aspartate receptor-mediated 

synaptic activity affects hippocampal formation gene 

expression patterns during early postnatal development. 

B. J. CLAIBORNE*; A. L. GROSS; M. SCHMIDT; J. S. 

BURGDORF; R. A. KROES; J. R. MOSKAL. Univ. New 

Mexico, Northwestern Univ. 

10:00 D39 336.3 The effects of exposure to nicotine early or 

late in adolescence on adult rat brain dopaminergic function. 

B. A. MCMILLEN*; L. T. WILLIAMS; M. C. ROGISTER; T. M. 

HALSEY; H. L. WILLIAMS. East Carolina Univ. 

11:00 D40 336.4 A rat model of variable prenatal stress. A. 

E. RONCA*; P. L. SCOTT; C. D. TULBERT; G. G. WINN; J. 

MORGAN; J. FEIMSTER; T. LUDWIG; L. BAER; C. WADE. 

Wake Forest Univ. Sch. Med., Wake Forest Univ. Sch. of 

Med., Brooks Army Base. 

8:00 D41 336.5 MiRNAs contribute to the postnatal 

maturation of the monkey hippocampus. G. A. FAVRE*; P. 

BANTA LAVENEX; P. LAVENEX. Univ. of Fribourg. 

9:00 D42 336.6 Human hippocampal formation in 

development: Neurochemical phenotype after perinatal 

injuries. J. GONZALEZ-FUENTES*; S. CEBADA-SÁNCHEZ; 

E. ARTACHO-PÉRULA; M. ARROYO-JIMÉNEZ; A. 

MOHEDANO-MORIANO; R. INSAUSTI; P. MARCOS; E. 

RIVAS-INFANTE. Univ. De Castilla-La Mancha, Hosp. Virgen 

del Rocío. 

10:00 E1 336.7 � Postnatal development of the monkey 

amygdala. L. J. CHAREYRON; P. BANTA LAVENEX; D. 

G. AMARAL; P. LAVENEX*. Lab. of Brain and Cognitive 

Develop., California Natl. Primate Res. Ctr. and The M.I.N.D. 

Inst., Univ. Fribourg. 

11:00 E2 336.8 • Pre- and post-natal environmental 

enrichment has immediate but not lasting consequences on 

offspring social behaviour. J. E. SPARLING*. Univ. of Ottawa. 

8:00 E3 336.9 Early-life stress results in precocious 

emergence of renewal and reinstatement effects, and early 

involvement of GABA inhibition in fear extinction in the 

developing rat. B. L. CALLAGHAN*; R. RICHARDSON. Univ. 

of New South Wales. 

9:00 E4 336.10 Postnatal development of somatostatin 

and neuropeptide Y distribution in the human dentate 

gyrus. S. CEBADA-SÁNCHEZ; J. GONZÁLEZ-FUENTES; 

M. ARROYO-JIMÉNEZ; E. RIVAS; J. MARTÍNEZ-RUIZ; 

A. MOHEDANO-MORIANO; E. ARTACHO-PÉRULA; R. 

INSAUSTI; M. MARCOS RABAL*. Univ. of Castilla-La Manc, 

Hosp. Virgen del Rocío. 

10:00 E5 336.11 • Molecular mechanism of reduced 

anxiety-like behavior in Monoamine Oxidase (MAO) B 

deficient mice. K. CHEN*; Y. B. CHEN; B. TABAKOFF; J. C. 

SHIH. Univ. South Calif, USC, Univ. of Cororado, Denver, 

Keck Sch. of Med. 



11:00 E6 336.12 Unmanipulated neonatal dentate gyrus 

cells show robust integration following transplantation into 

adult rat dentate gyrus. X. CHEN*; A. M. TOLKOVSKY; J. 

HERBERT. Cambridge Ctr. for Brain Repair. 

8:00 E7 336.13 Protein distribution of the Sp4 transcription 

factor in the mouse brain and Golgi analysis of structural 

defects in the hypomorphic Sp4 transgenic model. J. 

LALONDE*; G. B. GILL. Tufts Univ. 

POSTER 

337. Neurotrophins: Regulation and Signaling 


Mechanisms 


8:00 E8 337.1 Differential epigenetic regulation of 

BDNF and NT-3 genes in Neuro-2a cells. N. ISHIMARU*; M. 

FUKUCHI; A. TABUCHI; M. TSUDA; M. SHIRAISHI. Lab. of 

Pharmaceut. Therapy and Neuropharmacology, Grad. Sch. of 

M, Intl. Univ. of Hlth. and Welfare, Univ. of Toyama. 

9:00 E9 337.2 Effects of imipramine and citalopram on 

plasticity and BDNF levels in astrocytic and neuronal cell lines 

in vitro. J. DE VRY*; P. MARTÍNEZ-MARTÍNEZ; I. ROYAUX; 

G. KENIS; P. PEETERS; T. STECKLER; M. DE BAETS; H. 

W. M. STEINBUSCH; J. PRICKAERTS. Maastricht Univ., 

Johnson and Johnson PRD. 

10:00 E10 337.3 A two-chain SorCS2 variant is a novel 

co-receptor for proNGF-induced apoptosis. D. OLSEN*; 

S. GLERUP; S. L. S. SJØGAARD; S. SKELDAL; C. M. 

PETERSEN; A. NYKJÆR. Aarhus Univ. 

11:00 E11 337.4 Exogenous nerve growth factor (NGF) 

selectively modulates inhibitory synaptic transmission in 

cholinergic neurons in the medial septum/diagonal band of 

Broca (MS/DB). L. GUO*; H. H. YEH. Dartmouth Med. Sch. 

8:00 E12 337.5 Biological roles of the BDNF propeptide 

in the nervous system. T. MIZUI*; Y. ISHIKAWA; 

H. KUMANOGOH; M. KOJIMA. NATL INST ADV SCI AND 

TECHNOL (AIST), CREST, JST, Nara Inst. of Sci. and 

Technol., Kitasato Univ. Sch. of Med. 

9:00 E13 337.6 • Regional and temporal dynamics of 

BDNF protein expression in vivo and in vitro following 

kainic acid treatment. T. A. LANZ*; C. D. PILSMAKER; E. 

M. DRUMMOND; S. E. BOVE; G. W. CATELINA; W. O. 

ADAMOWICZ; A. MARIGA; S. J. ENGLE; J. A. DUMIN; R. J. 

KLEIMAN. Pfizer. 

10:00 E14 337.7 Sortilin positively modulates survival 

signaling by mature neurotrophins. M. RICHNER*; C. B. 

VAEGTER; P. JANSEN; A. W. FJORBACK; S. GLERUP; 

S. SKELDAL; B. ERDMANN; J. R. NYENGAARD; L. 

TESSAROLLO; G. R. LEWIN; T. E. WILLNOW; M. V. CHAO; 

A. NYKJAER. Aarhus Univ., Max-Delbrück-Center for Mol. 

Med., Ctr. for Cancer Research, Natl. Cancer Inst., Kimmel 

Ctr. at Skirball Inst. of Biomolecular Medicine, New York Univ. 

Sch. of Med. New York. 

11:00 E15 337.8 • Regional and temporal dynamics of BDNF 

mRNA transcript expression in the rat brain following kainic 

acid administration. S. E. BOVE*; A. MARIGA; T. A. LANZ; G. 

W. CADELINA; W. O. ADAMOWICZ; C. D. PILSMAKER; J. A. 

DUMIN; R. J. KLEIMAN. Pfizer, Inc. 

8:00 E16 337.9 Differential age-dependent responsiveness 

of TrkB neurotrophin receptor to BDNF and antidepressant 

drugs. T. P. RANTAMAKI*; A. DI LIETO; J. LINDHOLM; L. 

VESA; E. CASTREN. Univ. Helsinki. 


Mon. AM

9:00 E17 337.10 • Neurotropin ® stimulates neuronal 

expression of brain-derived neurotrophic factor. Y. FUKUDA; 

T. L. BERRY; M. NELSON; C. L. HUNTER; K. FUKUHARA*; 

H. IMAI; S. ITO; T. ISHIKAWA; A. GRANHOLM-BENTLEY; 

A. P. KAPLAN; T. MUTOH. Nippon Zoki Pharmaceut. Co Ltd, 

Med. Univ. of South Carolina, Fujita Hlth. Univ. Sch. of Med., 

NIH. 

10:00 E18 337.11 Loaded wheel running enhance BDNF 

function in the rat hippocampus. L. MINCHUL*; H. NOGAMI; 

K. INOUE; M. OKAMOTO; T. MATSUI; H. SOYA. Univ. of 

Tsukuba. 

11:00 E19 337.12 Effects of aging and exercise on the 

expression of neurotrophins and acetylcholine receptor in 

skeletal muscle. H. MAEJIMA*; R. KUNISHI; A. HAMASAKI; T. 

OTANI; T. KUROSE; M. DEIE. Teikyo Univ. of Sci., Hiroshima 

Univ. 

8:00 E20 337.13 CNS inflammation arising from aging and 

a peripheral infection reduces pro- and mature BDNF proteins 

at hippocampal synapses and impairs hippocampal L-LTP. G. 

P. CORTESE*; T. R. CHAPMAN; R. M. BARRIENTOS; S. F. 

MAIER; S. L. PATTERSON. Univ. of Colorado, Boulder. 

9:00 E21 337.14 Regulation of human BDNF gene 

transcription by neuronal activity. P. PRUUNSILD; M. SEPP; 

E. ORAV; T. TIMMUSK*. Tallinn Univ. Technol. 

POSTER 

338. GABA Receptors: Physiology I 


Mechanisms 


8:00 E22 338.1 Electrophysiological characterization of the 

functionally selective GABA receptor ligand Thio-4-PIOL at 

A 

recombinant and native GABA receptors. K. HOESTGAARD- 

A 

JENSEN*; M. BERGMANN; B. FRØLUND; N. DALBY; A. 

JENSEN. Fac. of Pharmaceut. Sci., H. Lundbeck A/S. 

9:00 E23 338.2 Activation of axonal GABA A receptors 

in cerebellar granule cells increases excitability and release 

probability. J. R. PUGH*; C. E. JAHR. Vollum Inst. 

10:00 E24 338.3 Influence of monoliganded states of 

GABA A R on GABAergic synaptic responses. A. BARBERIS*; 

E. PETRINI; F. SUCCOL; T. RAVASENGA. Italian Inst. Tech. 

11:00 E25 338.4 Modulation of the dorsal root and the 

monosynaptic reflex by high affinity α5 subunit-containing 

GABA A receptors in the turtle spinal cord. J. E. LOEZA 

ALCOCER*; J. AGUILAR; R. GONZÁLEZ-RAMÍREZ; R. 

FELIX; R. DELGADO-LEZAMA. Cinvestav-IPN, Dr. Manuel 

Gea González Gen. Hospital, Ministry of Hlth. 

8:00 E26 338.5 2’-Methoxy-6-methylflavone: A novel 

allosteric activator of α4β1/3δ GABAA receptors. N. KARIM*; 

N. GAVANDE; G. A. JOHNSTON; J. R. HANRAHAN; M. 

CHEBIB. The Univ. of Sydney. 

9:00 E27 338.6 • GABAA receptor subunits alpha 1, 2 

and 3 in hippocampus and frontal cortex in vitro: Tissuespecific 

receptor expression and functional response of 

neuronal networks. K. PODOLSKI; B. M. BADER; O. H. U. 

SCHROEDER; A. GRAMOWSKI*. NeuroProof GmbH, Univ. 

of Rostock. 

10:00 E28 338.7 Paired recordings of GABAergic inputs 

through voltage-sensitive dye imaging. S. WILLADT*; T. 

BIENVENU; M. CANEPARI; M. CAPOGNA; K. VOGT. 

Biozentrum, Univ. of Basel, Med. Res. Council, Anatom. 

Neuropharm. Unit. 

11:00 E29 338.8 Nanomolar sensitivity explains selectivity 

of the GABA analog THIP for extrasynaptic GABA A receptors. 

P. MEERA*; M. WALLNER; T. S. OTIS. Univ. of California Los 

Angeles. 

8:00 E30 338.9 Identifying functionally distinct GABA A 

receptor subtypes within the rodent brain using [ 35 S]TBPS 

binding. N. A. OTHMAN*; D. C. PERRY; T. G. HALES. The 

George Washington Univ., Univ. of Dundee. 

9:00 E31 338.10 Presynaptic delta subunit containing 

GABA_A receptors excite parallel fiber axons. S. S. DELLAL*; 

R. LUO; T. S. OTIS. UCLA. 

10:00 E32 338.11 Changes in the GABAergic regulation of 

the HPA axis following seizures. J. L. MAGUIRE*. Tufts Univ. 

Sch. of Med. 

11:00 E33 338.12 Nitric oxide enhances homomeric ρ 1 

GABA C receptor function. J. GASULLA; D. J. CALVO*. 

INGEBI CONICET-UBA. 

8:00 E34 338.13 Modulation of the human GABAρ1 

receptor by taurine. L. D. OCHOA-DE LA PAZ*, SR; I. A. 

MATINEZ-DAVILA; A. MARTINEZ-TORRES; R. MILEDI. Natl. 

Univ. of Mexico, Natl. Insitute of Mexico, Natl. Universityof 

Mexico, Univ. of California, Irvine. 

9:00 E35 338.14 Characterizing the modulatory effect 

of odorants at GABA(A) receptors. O. KLETKE*; O. A. 

SERGEEVA; A. POPPEK; S. MANTENIOTIS; H. HATT; G. 

GISSELMANN. Ruhr Univ. Bochum, Heinrich Heine Univ. 

10:00 E36 338.15 Strategies for measuring properties of 

native extrasynaptic GABAA receptors in granule cells of the 

mouse dentate gyrus. R. T. JONES*; I. MODY. UCLA Med. 

Sch. 

11:00 E37 338.16 • A piperidine derivative designed as a 

cocaine blocker is a potent agonist at GABA A receptors. D. B. 

WILLIAMS*; M. J. PRICE; J. J. HARP. Winston-Salem St Univ. 

8:00 E38 338.17 Macrolide antibiotics antagonize GABA(A) 

receptors. P. S. GARCIA*; A. JENKINS. Emory Univ. 

9:00 E39 338.18 Decreased inhibition/excitation ratio 

interferes with visual information processing and visuallyguided 

behavior in Xenopus. W. SHEN*; J. DEMAS; H. 

CLINE. The Scripps Res. Inst. 

10:00 E40 338.19 Allosteric potentiation of GABAA receptor 

chloride channels by glutamate. D. WU*; J. LIU; Y. WANG. 

Univ. British Columbia. 

11:00 E41 338.20 Tonic inhibitory current in turtle spinal 

interneurons might be mediated by alpha5 subunit-containing 

GABA A receptors. R. DELGADO-LEZAMA; A. SANDOVAL*; 

R. FELIX; A. CASTRO; J. AGUILAR; R. GONZÁLEZ- 

RAMÍREZ. Cinvestav-IPN, FES Iztacala UNAM, Bordeaux 

Univ., Dr. Manuel Gea González Gen. Hosp. 

8:00 E42 338.21 Light-modulated activation of GABA A 

receptors by a propofol-azobenzene conjugate. L. YUE*; 

M. PAWLOWSKI; F. FENG; K. S. BRUZIK; H. QIAN; D. R. 

PEPPERBERG. Univ. of Illinois at Chicago. 

9:00 E43 338.22 Increased Ca v 1.3, but not Ca v 1.2 L-VGCC 

subunit expression in the rat hippocampus during flurazepam 

withdrawal. D. E. EARL*; E. I. TIETZ. Univ. of Toledo Col. of 

Med. 



10:00 E44 338.23 A GABAA receptor α6 subunit rare variant 

associated with IGE alters α6β2Γ2 receptor channel gating 

and expression patterns. C. C. HERNANDEZ*; K. N. GURBA; 

N. HU; R. L. MACDONALD. Vanderbilt Univ. Med. Ctr. 

11:00 E45 338.24 Molecular basis of behavioral and 

biochemical muscimol selectivity for δ subunit-containing 

GABA A receptors. E. C. FITZMORRIS; P. MEERA; R. 

PONNUSAMY; M. S. FANSELOW; R. W. OLSEN; T. S. OTIS; 

M. WALLNER*. UCLA. 

8:00 E46 338.25 Motoneuron excitability may be modulated 

by tonic inhibition mediated by GABAA receptors. A. 

CASTRO; J. AGUILAR; R. FELIX; R. DELGADO-LEZAMA*. 

Bordeaux Univ., CINVESTAV-IPN. 

9:00 E47 338.26 Neurosteroids potently enhance 

synaptic GABA A receptor-mediated inhibition in medial 

parvocellular neurons of the paraventricular nucleus of the 

mouse hypothalamus. B. G. GUNN*; M. A. COOPER; J. J. 

LAMBERT; D. BELELLI. Univ. of Dundee. 

POSTER 

339. Sodium Channel Physiology I 


Mechanisms 


8:00 E48 339.1 An optimal proportion of sodium to 

potassium channel density in cortical neurons can account for 

energy-efficient action potentials. Y. YU*; D. MCCORMICK. 

Yale Univ. Sch. Med. 

9:00 E49 339.2 Differential block of transient and 

persistent Na+ currents in hippocampal CA1 pyramidal 

neurons. Y. PARK*; D. JOHNSTON; R. GRAY. The Univ. of 

Texas At Austin. 

10:00 E50 339.3 Isolation of somatic Na+ currents by 

selective inactivation of axonal channels with a voltage 

prepulse. L. S. MILESCU*; B. P. BEAN; J. C. SMITH. Harvard 

Med. Sch., NINDS, NIH. 

11:00 E51 339.4 Dopamine D1 receptor modulation 

of persistent Na channel gating in intact prefrontal cortex 

neurons. J. K. SEAMANS*; N. A. GORELOVA. UBC, Univ. of 

British Columbia. 

8:00 E52 339.5 Role of axonal NaV1.6 sodium channels in 

action potential generation in Layer 5 neocortical neurons. M. 

J. GUTNICK*; I. A. FLIEDERVISH; E. KATZ; A. SCHELLER; 

S. GOEBBELS; M. H. MEISLER; F. KIRCHHOFF; F. WOLF. 

Hebrew Univ. Jerusalem, Ben-Gurion Univ., Max Planck 

Inst. of Exp. Med., Univ. of Michigan, Univ. of Saarland, Max 

Planck Inst. for Dynamics. 

9:00 F1 339.6 Novel simplified state-topology for voltagegated 

sodium conductance in rat hippocampal CA1 neurons 

displays graded order activation, biexponential relatively 

voltage insensitive inactivation and persistent conductance. C. 

FRENCH*. Univ. of Melbourne, Royal Melbourne Hosp. 

10:00 F2 339.7 On the relationship between membrane 

excitability in nerve and a model of Na + channel gating in 

which activation and inactivation are coupled. J. R. CLAY*. 

NIH. 

11:00 F3 339.8 NaV1.6 is required for oxaliplatin-induced 

repetitive after-activity in peripheral myelinated axons. R. 

CARR*; R. SITTL; A. LAMPERT; J. FLECKENSTEIN; P. 

GRAFE. Ludwig-Maximilians Univ., Erlangen-Nürnberg Univ. 



8:00 F4 339.9 State-dependent modification of 

Nav1.6 sodium channels by pyrethroid insecticides. S. J. 

MCCAVERA*; J. TAN; B. HE; D. M. SODERLUND. Cornell 

Univ., Monsanto Co., Nankai Univ. 

9:00 F5 339.10 Voltage-gated sodium channel inner retinal 

function: Insights from Scn8a/Nav1.6-null mice. P. D. COTE*; 

B. J. SMITH. Dalhousie Univ. 

10:00 F6 339.11 Cross-species conservation of resurgent 

Na current reveals structural determinants of open-channel 

block by Na channel β4 peptides. A. H. LEWIS*; I. M. RAMAN. 

Northwestern Univ. 

11:00 F7 339.12 Tonic augmentation of tetrodotoxinresistant 

Na currents in cultured rat dorsal root ganglion 

neurons by endogenous CGRP. X. S. XIE*; B. ZOU; T. 

ÇOLAK; Y. ZHU; K. MEHTA; P. J. PASRICHA. Afasci Res. 

Laboratory, Afasci, Inc., Stanford Univ. 

8:00 F8 339.13 Real-time detection of the FGF14:Nav 

channel complex in live cells. A. S. SHAVKUNOV*; N. I. 

PANOVA-ELEKTRONOVA; J. WILLIAMS; R. L. VESELENAK; 

F. LAEZZA. Univ. of Texas Med. Branch, Galveston. 

9:00 F9 339.14 Selective silencing of Na V 1.7 mRNA 

expression in nodose ganglia (in vivo) abolishes action 

potential conduction in vagal C-fibers and A-fibers. Y. 

MUROI*; F. RU; B. J. CANNING; M. J. CARR; S. A. HUGHES; 

M. SIGG; M. KOLLARIK; B. J. UNDEM. Johns Hopkins Univ., 

GlaxoSmithKline. 

10:00 F10 339.15 • Protoxin-II and huwentoxin-IV share a 

common binding site on the voltage-gated sodium channel 

Na v 1.7. R. A. NEFF; A. BHATTACHARYA*; Q. WANG; N. WU; 

M. P. MAHER; A. D. WICKENDEN. Johnson & Johnson PRD 

LLC. 

11:00 F11 339.16 Fluorescent scorpion toxin mediates 

calcium-dependent internalization of sodium channels. A. 

R. MASSENSINI*; M. O. ANDRADE; M. A. M. PRADO; T. 

MORAES-SANTOS; M. F. D. MORAES. Univ. Federal De 

Minas Gerais, Robarts Res. Inst. 

8:00 F12 339.17 • Conotoxins that are gating modifiers 

versus pore blockers of voltage-gated sodium channels: Effect 

of NaVβ-subunit co-expression in Xenopus oocytes. M. J. 

WILSON; M. ZHANG; L. AZAM; B. M. OLIVERA; G. BULAJ; 

D. YOSHIKAMI*. Univ. Utah. 

9:00 F13 339.18 Influence of the endogenous openchannel 

blocking protein of Purkinje cells on the voltage- and 

dose-dependence of lidocaine inhibition of Na channels. J. 

BANT*; T. K. AMAN; I. M. RAMAN. Northwestern Univ. 

10:00 F14 339.19 Tetrodotoxin, dihydropyridine, and riluzole 

resistant persistent inward current: A novel sodium channel 

in rodent spinal neurons. Y. DAI*; L. M. JORDAN. Univ. 

Manitoba. 

11:00 F15 339.20 Compound-specific effects of mutations 

at V787 in DII-S6 of rNav1.4 sodium channels on inhibition 

by sodium channel blocker insecticides (SCBIs). R. T. VON 

STEIN*; D. M. SODERLUND. Cornell Univ. 

8:00 F16 339.21 Modeling larval Drosophila motoneurons 

to examine the functional effect of Na channel splice variants. 

C. GUNAY*; F. SIELING; L. DHARMAR; W. LIN; R. MARLEY; 

R. A. BAINES; A. PRINZ. Emory Univ., Georgia Inst. of 

Technol., Univ. of Manchester. 

9:00 F17 339.22 • Molecular and functional differences in 

voltage-activated Na channels between GABA neurons and 

dopamine neurons in substantia nigra. S. DING; F. ZHOU*. 

Univ. Tennessee. 


Mon. AM

10:00 F18 339.23 Two novel scorpion toxins specifically 

modulating Nav1.4 and Nav1.7 channels. J. TYTGAT*; T. 

VANDENDRIESSCHE; T. OLAMENDI-PORTUGAL; F. Z. 

ZAMUDIO; L. D. POSSANI. Univ. Leuven (KUL) Lab. Toxicol, 

Inst. de Biotecnologia. 

11:00 F19 339.24 Differential sensitivity to antiepileptic drugs 

of action potential firing in glutamatergic versus GABAergic 

neurons. B. C. CARTER; B. P. BEAN*. Harvard Med. Sch. 

POSTER 

340. Potassium Channel Physiology I 


Mechanisms 


8:00 F20 340.1 Stoichiometry of potassium M-channel 

activation by PIP . V. TELEZHKIN; D. A. BROWN*; A. J. 

2 

GIBB. Univ. Col. London. 

9:00 F21 340.2 The specific slow afterhyperpolarization 

inhibitor UCL2077 is a subtype-selective blocker of 

the epilepsy associated KCNQ channels. H. SOH; A. 

TZINGOUNIS*. Univ. of Connecticut, Univ. Connecticut. 

10:00 F22 340.3 KCNQ channels are located at multiple 

sites in micturition pathways - An in vivo study in the rat. J. 

ZHENG*; K. THOR; F. KULLMANN. Urogenix Inc. 

11:00 F23 340.4 KCNQ5 channels determine resting 

properties of presynaptic membrane. H. HUANG; L. O. 

TRUSSELL*. Oregon Hlth. Sci. Univ. 

8:00 F24 340.5 KCNQ2 conditional knockout in mouse. C. 

H. KING*. Univ. Pennsylvania. 

9:00 F25 340.6 KCNQ channel openers induce a strong 

hypothermic response in the mouse. L. V. KRISTENSEN; A. 

N. NIELSEN; K. S. NIELSEN*; H. H. HANSEN. NeuroSearch 

A/S, Neurosearch A/S. 

10:00 F26 340.7 • Selective involvement of the ether-àgo-go 

K + channel BEC1/KCNH3 in cognitive function. S. 

TAKAHASHI; Y. NAKAMURA*; K. INAMURA; A. MIYAKE. 

Astellas Pharma Inc, Okinawa Inst. of Sci. and Technol., 

Doshisha Univ. 

11:00 F27 340.8 • Erg channels modulate excitability in 

juvenile mouse Purkinje neurons. J. R. SCHWARZ*; D. 

NICULESCU. Univ. Hamburg. 

8:00 F28 340.9 Maternal isolation affects function of GIRK 

channels in neurons of the hippocampus but not the raphe 

nucleus. T. SHIRASAKI*; A. M. SHEHATA; F. SOEDA; K. 

TAKAHAMA. Grad. Sch. Pharm. Sci., Kumamoto Univ. 

9:00 F29 340.10 Epigenetic regulation of astrocytic genes 

following spinal cord injury. M. L. OLSEN*; H. SONTHEIMER. 

Univ. Alabama, Birmingham. 

10:00 F30 340.11 Single channel detection with potassium 

selective microelectrodes. P. J. SMITH*; L. P. COLLIS; M. A. 

MESSERLI. Marine Biol. Lab. 

11:00 F31 340.12 Lactate excites cortical neurons via 

ATP sensitive K+ channels closure. A. KARAGIANNIS; F. 

PLAISIER; T. GALLOPIN; C. DAVID; H. GEOFFROY; J. F. 

STAIGER; E. HILLMAN; J. ROEPER; B. CAULI*. CNRS - 

UPMC, ESPCI, Inst. for Anat. and Cell Biol., Columbia Univ., 

Inst. of Neurophysiology, Goethe-University. 

8:00 F32 340.13 • Loss of the Kv1.3 potassium channel 

alters transcriptional regulation and interneuron populations 

in the cerebral cortex. V. GAZULA*; A. DUQUE; L. K. 

KACZMAREK. Yale Univ. Med. Sch. 

9:00 F33 340.14 The interaction of sodium-activated 

potassium channels and the Fragile X Mental Retardation 

Protein regulates membrane excitability in peptidergic neurons 

of Aplysia. Y. ZHANG*; M. BROWN; C. HYLAND; Y. CHEN; J. 

KRONENGOLD; M. FLEMING; L. KACZMAREK. Yale Univ. 

Sch. Med. 

10:00 F34 340.15 Sodium permeability of the Slack-B 

sodium-activated potassium channel. J. KRONENGOLD*; M. 

R. BROWN; M. R. FLEMING; L. K. KACZMAREK. Yale Univ. 

Sch. of Med. 

11:00 F35 340.16 Phosphorylation that activates Slack 

sodium-activated potassium channels may alter channelprotein 

interactions at the plasma membrane. M. R. 

FLEMING*; J. KRONENGOLD; M. R. BROWN; Y. YAN; 

H. CHEN; T. T. LAM; F. J. SIGWORTH; A. C. NAIRN; L. K. 

KACZMAREK. Yale Univ. Sch. Med., SUNY Univ. at Albany. 

8:00 F36 340.17 The C-terminus of the sodium-activated 

potassium channel Slack is missing in neurons from Fmr1 

knockout mice. M. R. BROWN*; J. KRONENGOLD; V. 

GAZULA; D. NAVARATNAM; L. K. KACZMAREK. Yale Univ. 

9:00 F37 340.18 Identification and characterization of Trek2 

splice isoforms in the mouse CNS. K. R. MIRKOVIC*; K. 

WICKMAN. Univ. of Minnesota. 

10:00 F38 340.19 Protein kinase G (PKG) bidirectionally 

modulates TASK1 currents in PKG-loaded HEK 293 cells. H. 

TOYODA*; M. SAITO; M. OKAZAWA; K. HIRAO; H. SATO; 

H. ABE; K. TAKADA; K. FUNABIKI; M. TAKADA; T. KANEKO; 

Y. KANG. Osaka Univ. Grad. Sch. Dent., Osaka Biosci. Inst., 

Primate Res. Inst., Kyoto Univ., Grad. Sch. Med., Kyoto Univ. 

11:00 F39 340.20 Functional expression of an oxygensensitive 

TASK-like background k+ channel in the adult 

rat carotid body type-I cells. F. C. ORTIZ*; R. DEL RIO; R. 

ITURRIAGA; R. VARAS. P. Univ. Catolica De Chile. 

8:00 F40 340.21 • Cocaine triggers persistent weakening 

of metabotropic postsynaptic inhibition in dopamine neurons 

of the ventral tegmental area. D. M. HALUK*; D. ARORA; K. 

WICKMAN. Univ. of Minnesota. 

9:00 F41 340.22 Distinct subcellular distribution of 

differentially phosphorylated Kv1.2 potassium channels in 

rat brain and in heterologous cells. A. M. BUNDROS; C. F. 

MANNING; O. A. CERDA; J. S. TRIMMER*. Univ. California, 

Davis, UC Davis SOM. 

10:00 F42 340.23 Vesicular trafficking of dendritic 

ion channels. H. MISONOU*; C. S. JENSEN; H. B. 

RASMUSSEN; S. OLESEN. Univ. Maryland Baltimore, Univ. 

of Copenhagen, Univ. of Maryland. 

11:00 F43 340.24 Polarized axon-dendrite targeting of Kv3 

(Shaw) channels is controlled by the interplay of ankyrin G 

and kinesin I. C. GU*. Ohio State Univ. 



POSTER 

341. Calcium-Activated Potassium Channels 


Mechanisms 


8:00 F44 341.1 The BK channel as a potential 

pharmacological target in the treatment of spinal cord injury. 

J. A. BUTTIGIEG*; H. YE; Y. WAN; M. G. FEHLINGS. Toronto 

Western Hospital, Univ. Hlth. Network. 

9:00 F45 341.2 Regulation of BK channel trafficking by the 

accessory beta4 subunit. S. SHRUTI*; L. B. FRENCH; A. L. 

BARTH. Carnegie Mellon Univ., Allegheny Col. 

10:00 F46 341.3 The four amino acid sequence SRKR 

in the alpha subunit partially modulates arachidonic acid 

sensitivity of BK-channels. D. D. DENSON*; J. LI; O. AL- 

KHALILI; D. C. EATON. Emory Univ. Sch. Med. 

11:00 F47 341.4 Hypoxia-induced conformational 

rearrangements in the BK channel RCK1-RCK2 linker 

determined by fluorescence lifetime imaging microscopy 

(FLIM). I. C. ROWE*; F. SALEEM; H. MCCLAFFERTY; O. 

JEFFRIES; E. ROWAN; C. MCCARTNEY; R. DUNCAN; M. 

SHIPSTON. Edinburgh Univ., Univ. of Strathclyde. 

8:00 F48 341.5 Mis-expression of a gain-of-function 

BK channel alters circadian rhythms in neural activity. A. 

MEREDITH*; J. MONTGOMERY. Univ. of Maryland Sch. of 

Med. 

9:00 F49 341.6 Firing properties of medium spiny 

projection neuron in striatum could be modulated by the 

long-lasting spontaneous calcium rhythm. M. OSANAI*; A. 

TAMURA; I. MORI. Tohoku Univ. Grad. Sch. of Med., JST, 

CREST. 

10:00 F50 341.7 PI3 kinase activity is necessary for 

maintenance of the BK-mediated fast afterhyperpolarization. 

S. J. SPRINGER*; L. SCHRADER. Tulane Univ. 

11:00 F51 341.8 Modeling study of BK potassium channel 

in midbrain DA neuron. A. Y. KUZNETSOVA*. 

8:00 F52 341.9 Kinetics and modulation of voltageclamped 

BK and SK K(Ca) currents in dissociated Purkinje 

neurons during spike-like stimulus trains. M. D. BENTON*; I. 

M. RAMAN. Northwestern Univ. 

9:00 F53 341.10 The role of calcium-activated potassium 

channels in the apoptotic volume decrease of glioma cells. 

M. B. MCFERRIN*; H. SONTHEIMER. Univ. Alabama 

Birmingham. 

10:00 F54 341.11 Ca v 1.3 calcium channels serve as key 

players in activating SK currents in mouse chromaffin cells. 

D. H. VANDAEL*; A. MARCANTONI; S. MAHAPATRA; D. 

GAVELLO; V. CARABELLI; J. STRIESSNIG; E. CARBONE. 

Univ. of Torino, Univ. of Innsbruck. 

11:00 F55 341.12 Facilitatory actions of subanesthetic 

propofol on glutamate release in the hippocampal CA1 region 

of adult mice. T. OTSUBO; T. FUKUSHIMA; S. KOKUBU; M. 

SHIRAKAWA; T. TERASHIMA; S. YAMAGUCHI; Y. HORI*. 

Dokkyo Univ. Sch. Med. 

8:00 F56 341.13 Small conductance KCa2 channels are 

essential for preventing delayed calcium deregulation in 

models of glutamate toxicity. A. M. DOLGA*; J. GROHM; 

S. PFEIFER; S. TOBABEN; N. PLESNILA; C. CULMSEE. 

Philipps-Universität Marburg, Royal Col. of Surgeons in 

Ireland (RCSI), Ludwig-Maximilians-Universität München. 



9:00 F57 341.14 The Ca 2+ activated SK3 channel: 

Expression in rat striatum and contribution to microgliamediated 

neurotoxicity in vitro. L. C. SCHLICHTER*; 

V. KAUSHAL; I. MOXON-EMRE; V. SIVAGNANAM; C. 

VINCENT. Toronto Western Res. Inst., Univ. of Toronto. 

10:00 F58 341.15 The influence of the small conductance 

calcium-activated potassium (SK, K Ca2 ) channel activator 

1-ethyl-2-benzimidazolinone (1-EBIO) on hippocampal singleunit 

responses in freely moving C57BL/6J mice. R. LEE*; R. 

W. STACKMAN, Jr. Florida Atlantic Univ. 

11:00 G1 341.16 Genetic deletion of the long form of the 

small conductance Ca2+-activated K+ channel type 2 subunit 

(SK2 Short only) produces differential effects on hippocampal 

memory. R. W. STACKMAN*, Jr.; K. A. VICK; K. J. SMITH; C. 

T. BOND; J. MAYLIE; J. P. ADELMAN. Florida Atlantic Univ., 

Oregon Hlth. & Sci. Univ. 

8:00 G2 341.17 Developmental regulation of small 

conductance calcium-activated potassium (SK) channels 

in the hippocampus. C. BALLESTEROS-MERINO; C. 

FERRANDIZ-HUERTAS; C. BOND; M. WATANABE; J. 

MAYLIE; J. P. ADELMAN; R. LUJAN*. Univ. Castilla-La 

Mancha, Vollum Inst., Hokkaido Univ. Sch. of Med., OHSU. 

9:00 G3 341.18 SK channels as regulators of synaptically 

induced bursting and neural synchrony. G. DRION; A. 

COLLARD; J. J. MOREAU*; V. SEUTIN; R. SEPULCHRE. 

Univ. Liege. 

10:00 G4 341.19 Coupled activity-dependent trafficking of 

synaptic sk2 channels and ampa receptors. M. T. LIN*; R. 

LUJAN; M. WATANABE; M. FRERKING; J. MAYLIE; J. P. 

ADELMAN. OHSU, Univ. de Castilla-La Mancha, Hokkaido 

Univ. 

11:00 G5 341.20 SK channels underlying medium 

afterhyperpolarizations and excitability control in dentate 

gyrus granule cells. P. MATEOS-APARICIO MORENO*; F. A. 

TUVNES; J. F. STORM. Inst. of Basic Med. Sci. (IMB), Univ. 

of Oslo, Ctr. for Mol. Biol. and Neurosci. (CMBN). 

8:00 G6 341.21 Characterization of a novel and 

functionally distinct mammalian SK2 channel splice variant. J. 

ZHANG*; L. HE. Jefferson Med. Coll. 

POSTER 

342. Synaptic Transmission: Modulation by Ach, Amino Acids, 

and GABA 


Mechanisms 


8:00 G7 342.1 CaMKII mediates serotonergic 

enhancement of GABAergic neurotransmission in pyramidal 

neurons of the rat visual cortex. H. JANG; K. CHO; S. PARK; 

D. RHIE*. Coll Med. Catholic Univ. Korea. 

9:00 G8 342.2 Differential roles of GABA transporters 

in the regulation of extracellular concentrations of GABA in 

the rat hippocampus. F. KERSANTÉ; S. C. S. ROWLEY; 

M. GUTIÈRREZ MECINAS; J. M. H. M. REUL; A. C. 

LINTHORST*. Univ. of Bristol. 

10:00 G9 342.3 Acute ethanol exposure excites cerebellar 

stellate interneurons. A. WADLEIGH; C. F. VALENZUELA*. 

Univ. New Mexico HSC. 


Mon. AM

11:00 G10 342.4 • Diffuse brain injury disrupts glutamate 

signaling in the rat striatum two days post-injury: An enzymebased 

microelectrode array study. J. M. HINZMAN*; T. C. 

THOMAS; J. QUINTERO; P. HUETTL; F. POMERLEAU; G. A. 

GERHARDT; J. LIFSHITZ. Univ. of Kentucky. 

8:00 G11 342.5 Modulation of synaptic transmission in the 

hippocampal CA1 region by endogenous acetylcholine: Novel 

findings and approaches. D. NAGODE*; B. E. ALGER. Univ. 

Maryland Sch. of Med. 

9:00 G12 342.6 Effect of location of inhibition on 

NMDA spikes in pyramidal cells. M. JADI*; A. POLSKY; J. 

SCHILLER; B. W. MEL. Univ. So. California, Technion Med. 

Sch. 

10:00 G13 342.7 Cholinergic suppression of evoked 

synaptic responses in layer II of the parasubiculum. S. D. 

GLASGOW*; I. GLOVACI; C. A. CHAPMAN. Concordia Univ. 

11:00 G14 342.8 Postsynaptic cell type-dependent 

cholinergic regulation of GABAergic synaptic transmission 

in rat insular cortex. K. YAMAMOTO*; N. KOSHIKAWA; M. 

KOBAYASHI. Dept. of Pharmacology, Nihon Univ. Sch. of 

Dent. 

8:00 G15 342.9 Effects of vitamin B6 on the cell 

proliferation and neuroblast differentiation in the mice dentate 

gyrus: Correlation with GABA shunt enzymes. D. YOO*; W. 

KIM; S. NAM; J. CHUNG; M. WON; Y. YOON; I. HWANG. 

Seoul Natl. Univ., Seoul Natl. Univ. Hosp., Hallym Univ. 

9:00 G16 342.10 Equilibrative nucleoside transporter 

1 (ENT1) regulates hypoxic/ischemic adenosine levels 

in hippocampal slices. D. ZHANG; B. C. ALBENSI; F. E. 

PARKINSON*. Univ. Manitoba, St Boniface Res. Ctr. 

10:00 G17 342.11 M1 and M4 receptors modulate 

hippocampal pyramidal neurons. A. T. GULLEDGE*; S. 

DASARI. Dartmouth Med. Sch. 

11:00 G18 342.12 Effects of neuronal activity on D-serine 

extracellular concentration in vivo. P. PERNOT; C. MAUCLER; 

N. VASYLIEVA; S. MARINESCO*. INSERM U628-UCB Lyon 

I. 

8:00 G19 342.13 Persistent pain induces plastic changes in 

the anxiety behavior and the NMDA receptor functions of the 

central nucleus of the amygdala in serine racemase knockout 

mice. S. WAKAMATSU; H. TSUZUKI; M. MAEKAWA*; R. 

KONNO; Y. HORI. Dokkyo Med. Univ. Sch. Med., Int Univ. 

Hlth. & Welf. 

9:00 G20 342.14 Cholinergic receptor activation differently 

modulates synaptic communication between distinct types 

of perisomatic inhibitory cells and pyramidal neurons in 

the CA3 region of mouse hippocampus. G. G. SZABO*; N. 

HOLDERITH; A. I. GULYÁS; T. F. FREUND; N. HÁJOS. Inst. 

of Exptl. Med. Hungarian Acad. of Sci. 

10:00 G21 342.15 Interaction of Gq-linked serotonergic 

and cholinergic receptors in cortical pyramidal neurons. D. 

AVESAR*; A. T. GULLEDGE. Dartmouth Med. Sch. 

11:00 G22 342.16 BHB does not alter GABA signals in 

neonatal slices: sweet slices are fine, no need to alter 

conventional ACSF. M. A. PICARDO; R. NARDOU; R. 

TYZIO; C. ALLENE; S. YAMAMOTO; S. SIVAKUMARAN; 

M. D. CAIATI; R. SYLVAIN; M. MINLEBAEV; P. FERRÉ; R. 

KHAZIPOV; J. L. ROMETTE; J. LORQUIN; G. CHAZAL; R. 

COSSART; I. KHALILOV; A. NEHLIG; E. CHERUBINI; Y. Y. 

BEN-ARI*. INSERM/INMED U901, Neurobio. Department, 

Intl. Sch. for Advanced Studies (SISSA), INSERM, UMR-S 

872, Ctr. de Recherche des Cordeliers and Univ. Pierre 

et Marie Curie-Paris 6, Ecole Supérieur d’Ingénieurs de 

Luminy-Case 925, Inst. de Recherche pour le Développement 

(IRD), Microbiologie et Biotechnologie des Environnements 

Extrêmes, UMR-D180, Inserm U666. 

8:00 G23 342.17 Cortical cholinergic signaling in TRPC5 

and TRPC6 knockout mice. S. DASARI*; J. ABRAMOWITZ; 

L. BIRNBAUMER; A. T. GULLEDGE. Dartmouth Med. Sch., 

NIEHS/NIH. 

9:00 G24 342.18 The effect of the membrane probe 

dipicrylamine on GABA-A receptor function. M. CHISARI*; K. 

WU; C. ZORUMSKI; S. MENNERICK. Washington Univ. 

10:00 G25 342.19 Confocal imaging of muscarinic receptor 

mediated PI(4,5)P2-dynamics in CA1 pyramidal neurons. S. 

HACKELBERG*; D. OLIVER. Philipps Univ. Marburg. 

11:00 G26 342.20 Cholinergic modulation of intrinsic 

oscillatory properties in dendritic versus perisomatic-targeting 

CCK+ CA1 hippocampal interneurons. C. A. CEA-DEL RIO*; 

J. LAWRENCE; L. TRICOIRE; F. ERDELYI; G. SZABO; C. J. 

MCBAIN. NICHD/NIH, Univ. de Valparaiso, Univ. of Montana, 

Hungarian Acad. of Sci. 

8:00 G27 342.21 Selective cholinergic modulation of fast 

firing interneurons in the basolateral amygdala. L. LIU*; F. 

MASCAGNI; A. J. MCDONALD; D. D. MOTT. Univ. South 

Carolina Sch. of Med. 

9:00 G28 342.22 Modulation of glycinergic mIPSCs in 

principal cells of the mouse medial nucleus of the trapezoid 

body. A. GARRETT; B. WALMSLEY*. Synapse and Hearing 

Lab. 

10:00 G29 342.23 Dendritic GABA-B receptors contribute to 

propofol-induced depression. V. DARGIS-ROBINSON; Y. NA; 

B. MACIVER*. Stanford Univ. Sch. Med. 

11:00 G30 342.24 Dendrite-preferring interneurones in 

the CA2 region of the hippocampus. A. MERCER*; N. A. 

BOTCHER; K. EASTLAKE; A. M. THOMSON. Sch. Pharm. 

8:00 G31 342.25 Reorganization of striatal microcircuits in 

a mouse model of Parkinson’s disease. A. H. GITTIS*; A. C. 

KREITZER. Gladstone Inst. For Neurolog. Dis. 

POSTER 

343. Oscillations and Synchrony: EEG Studies 


Mechanisms 


8:00 G32 343.1 Coherent activity in brain areas 

subserving memory function after induction of propofol 

anesthesia. V. S. WEINER*; S. S. CASH; E. N. ESKANDAR; 

R. A. PETERFREUND; E. T. PIERCE; M. D. SZABO; A. F. 

SALAZAR; A. M. CHAN; J. E. CORMIER; A. R. DYKSTRA; R. 

ZEPEDA; E. N. BROWN; P. L. PURDON. MIT, Massachusetts 

Gen. Hosp., Harvard-MIT Hlth. Sci. and Technol., Harvard 

Med. Sch. 



9:00 G33 343.2 Hysteretic phase transition in 

an anesthetically induced loss of consciousness. E. 

HWANG*; S. KIM; J. CHOI. Pohang Univ. of Sci. and 

Technology(POSTECH), Korea Inst. of Sci. and Technol. 

10:00 G34 343.3 Thalamocortical mechanisms for a 

propofol-induced alpha rhythm. S. CHING*; A. CIMENSER; P. 

L. PURDON; E. N. BROWN; N. J. KOPELL. Massachusetts 

Gen. Hosp., Boston Univ., MIT, Harvard Med. Sch. 

11:00 G35 343.4 Collective dynamics of high density EEG 

reveals a single dominant mode of activity during general 

anesthesia-induced unconsciousness. A. CIMENSER*; 

E. T. PIERCE; A. F. SALAZAR GOMEZ; J. WALSH; P. G. 

HARRELL; C. L. TAVARES-STOECKEL; K. HABEEB; P. 

PURDON; E. N. BROWN. Massachusetts Gen. Hosp., 

Harvard Med. Sch., MIT. 

8:00 G36 343.5 Only the nose knows: Is there an actual 

correspondence between respiration and slow sleep-like 

brain waves? A. V. SHARMA*; C. SOBSEY; E. CLEMENT; T. 

WOLANSKY; C. T. DICKSON. Univ. of Alberta. 

9:00 G37 343.6 Cortical connectivity and synchrony 

in human intracranial recordings of sleep spindles. A. S. 

TUAN*; S. S. CASH; E. N. ESKANDAR; D. L. SCHOMER; E. 

HALGREN. UCSD Sch. of Med., Massachusetts Gen. Hosp., 

Beth Israel Deaconess Med. Ctr., Univ. of California, San 

Diego Sch. of Med. 

10:00 G38 343.7 Time-frequency interference analysis of 

EEG recordings enhances neuronal dynamics categorization. 

J. DIAZ*; J. LETELIER; N. DUQUE; A. BASSI; E. VIVALDI. 

Univ. of Chile, Univ. de Chile. 

11:00 G39 343.8 • Phase synchrony and causality analysis 

induced by regional low frequency repetitive transcranial 

magnetic stimulation. W. KIM*; M. LEE; H. W. LEE. Ewha 

Womans Univ. Sch. of Med., Ewha Med. Res. Inst. 

8:00 G40 343.9 • The stability of functional networks in 

long-term EEG. C. J. CHU-SHORE*; M. A. KRAMER; M. T. 

BIANCHI; J. S. PATHMANATHAN; L. WIZON; T. CHENG; S. 

S. CASH. Massachusetts Gen. Hospital/Harvard Med. Sch., 

Boston Univ. 

9:00 G41 343.10 Hippocampal theta acceleration by 

electrical stimulation of the median raphe nucleus. L. NGUY; 

P. WELBERT; B. KOCSIS*. Harvard Med. Sch. 

10:00 G42 343.11 Human hippocampal theta oscillations 

show performance-dependent phase-locking during a 

working memory task. P. LENCK-SANTINI*; J. K. KLEEN; B. 

JOBST; G. L. HOLMES; K. KULANDAIVEL; K. BUJARSKI; V. 

THADANI; T. DARCEY. Dartmouth Med. Sch. 

11:00 G43 343.12 Phase-locked local gamma network 

activation is a prominent component of the hippocampal slow 

oscillation. T. A. WHITTEN*; T. WOLANSKY; C. T. DICKSON. 

Univ. of Alberta. 

8:00 G44 343.13 Are human cortical slow oscillations during 

NREM sleep travelling waves or are they synchronized across 

the cortex? J. S. SHERFEY*; S. S. CASH; N. DEHGHANI; 

E. HALGREN. Univ. of California, San Diego Sch. of Med., 


9:00 G45 343.14 EEG alpha activity segmental 

characteristics as a reflection of neuronal assemblies’ 

dynamics during arithmetical tasks. S. BORISOV*; S. 

SHISHKIN; H. LAUFS; A. KAPLAN. Johann Wolfgang 

Goethe-University, Lomonosov Moscow State Univ. 



10:00 G46 343.15 Predicting surface EEG power through 

fluctuations in intracortical signals during different behavioral 

and pharmacological conditions. S. MUSALL*; N. K. 

LOGOTHETIS; K. S. WHITTINGSTALL. Max Planck Inst. For 

Biol. Cybernetics, Univ. 

11:00 G47 343.16 Spatio-temporal metastability: Design for 

a brain. J. A. S. KELSO*; E. TOGNOLI. Florida Atlantic Univ., 

Univ. of Ulster. 

8:00 G48 343.17 Long-range dependent correlations of the 

EEG alpha envelope in experimental data and the Jansen- 

Rit neural mass model. F. VON WEGNER*; S. BORISOV; K. 

JAHNKE; M. MAISCHEIN; A. MORZELEWSKI; H. LAUFS. 

Goethe Univ. 

9:00 G49 343.18 • A new method of EEG analysis - Data 

driven EMD. T. M. RUTKOWSKI; A. W. PRZYBYSZEWSKI*; 

T. TANAKA; D. MANDIC; A. CICHOCKI. RIKEN Brain Sci. 

Inst., Univ. of Massachsetts Med. Sch., Tokyo Univ. of Agr. 

and Technol., Imperial Col. London. 

10:00 G50 343.19 The role of astrocytes in gamma 

oscillations in the brain. H. S. LEE*; A. GHETTI; A. PINTO- 

DUARTE; F. GALIMI; J. PINA-CRESPO; G. SANNA; I. 

VERMA; T. SEJNOWSKI; S. F. HEINEMANN. The Salk Inst., 

The Scripps Res. Inst. 

POSTER 

344. Neuron-Glia Interactions and Astrocyte Activity I 


Mechanisms 


8:00 G51 344.1 • Mechanisms of Ca2+ responses in 

brainstem astrocytes evoked by pH changes. V. KASYMOV*; 

O. LARINA; N. MARINA; B. H. LIU; S. KASPAROV; A. V. 

GOURINE. Univ. Col. London, Univ. of Bristol. 

9:00 G52 344.2 Optogenetic monitoring and control 

of astrocyte activity in vivo. A. V. GOURINE*; N. 

MARINA; V. KASYMOV; M. FIGUEIREDO; F. TANG; A. 

TESCHEMACHER; S. KASPAROV. Univ. Col. London, Univ. 

of Bristol. 

10:00 G53 344.3 Opto-genetic analysis of glia-neuronal 

interactions in locus coeruleus. S. LANE; M. FIGUEIREDO; 

S. KOUTSIKOU*; S. KASPAROV; A. G. TESCHEMACHER. 

Univ. of Bristol. 

11:00 G54 344.4 Opto-genetic investigation of neuronal and 

astrocytic contributions to BOLD signal with fMRI at 9.4T. S. 

KASPAROV*; J. A. WELLS; N. MARINA; M. FIGUEIREDO; S. 

LANE; J. HEWINSON; S. WALKER-SAMUEL; K. M. SPYER; 

A. G. TESCHEMACHER; M. F. LYTHGOE; A. V. GOURINE. 

Univ. Bristol, Univ. Colledge London. 

8:00 G55 344.5 Optogenetic control of astrocytic ATP 

release in vitro and in vivo. M. FIGUEIREDO; F. TANG; A. V. 

GOURINE; A. G. TESCHEMACHER; L. F. DONALDSON*; S. 

KASPAROV. Univ. Bristol, Univ. Col. London. 

9:00 G56 344.6 Ischemic spreading depolarizations 

coincide with acute neuronal and astroglial damage as shown 

by in vivo two-photon imaging. W. C. RISHER*; D. ARD; J. 

YUAN; S. KIROV. Med. Coll Georgia. 

10:00 G57 344.7 Astrocytic calcium signals are required 

for functional integrity of tripartite synapses. M. TANAKA*; 

H. GOMI; J. NAKAI; A. LEBEDINSKIY; P. SHIH; R. ANDO; 

K. MIKOSHIBA; A. SEMYANOV; S. ITOHARA. Brain Sci. 

Inst,Riken, Gunma Univ., Saitama Univ. 


Mon. AM

11:00 G58 344.8 Astrocyte swelling in high K+: implications 

for SICs and epilepsy. T. R. MURPHY*; T. A. FIACCO. Univ. of 

California, Riverside. 

8:00 H1 344.9 Recording microdomains of neuron-toastrocyte 

communication at single synapses. M. SUN*; T. A. 

FIACCO. Dept. of Cell Biol. and Neuroscience, UC Riverside. 

9:00 H2 344.10 Astrocyte-dependent regulation of 

synaptic NMDA receptors modulates seizure activity. J. 

CLASADONTE*; J. DONG; P. G. HAYDON. Tufts Univ. Sch. of 

Med. 

10:00 H3 344.11 • Mapping hippocampal astrocyte calcium 

responses to single CA1 pyramidal neuron stimulation using 

light-activated channelrhodopsin-2. Y. BERNARDINELLI*; C. 

SALMON; E. V. JONES; W. T. FARMER; K. K. MURAI. Univ. 

of Geneva, McGill Univ. 

11:00 H4 344.12 The biophysical basis of glutamate and 

amyloid-beta mediated spontaneous intercellular calcium 

waves in astrocytes. C. L. MACDONALD*; G. A. SILVA. UC 

San Diego. 

8:00 H5 344.13 Basal astrocyte calcium tunes inhibitory 

synapse efficacy. X. TONG*; B. KHAKH. David Geffen Sch. of 

Medicine, UCLA, David Geffen Sch. of Med. 

9:00 H6 344.14 Dynamics of metabotropic glutamate 

receptor 5 in astrocytes through single particle tracking and 

calcium imaging. J. M. KOWALEWSKI*; E. AMIGOU; C. 

GIAUME; A. TRILLER. Collège de France, Inst. de Biologie de 

l’Ecole Normale Supérieure. 

10:00 H7 344.15 AQP4 amplifies osmotically induced 

ATP release and Ca2+ signaling in cortical astrocytes. 

A. S. THRANE; P. M. RAPPOLD; T. FUJITA; R. ENGER; 

A. P. TORRES; Ø. SKARE; A. KLUNGLAND; L. BEKAR; 

N. N. H. YASEIN; V. R. THRANE; O. P. OTTERSEN; M. 

NEDERGAARD; E. A. NAGELHUS*. Univ. of Oslo, Ctr. for 

Translational Neuromedicine. 

11:00 H8 344.16 • Astrocytic Ca 2+ -activated anion channel, 

Bestrophin-1 is permeable to glutamate and GABA. S. OH; B. 

YOON; C. J. LEE*. Korea Inst. of Sci. and Technol. 

8:00 H9 344.17 • p38α regulates production of specific 

cytokines and chemokines in astrocytes. U. LO*; V. 

SELVARAJ; D. J. DAUGHERTY; K. OTSU; W. DENG. Univ. 

of California At Davis, Osaka Univ. Grad. Sch. of Med., Inst. of 

Pediatric Regenerative Med. 

9:00 H10 344.18 Polyamines and brain signaling: Use of 

a novel spermine biosensor. Y. V. KUCHERYAVYKH*; H. 

KURATA; M. INYUSHIN; L. Y. KUCHERYAVYKH; R. W. VEH; 

A. REICHENBACH; N. BURNASHEV; S. M. ANTONOV; Y. M. 

SHUBA; O. BOLDYRYEV; M. J. EATON; C. G. NICHOLS; S. 

N. SKATCHKOV. Univ. Central Del Caribe, Washington Univ. 

Sch. of Med., Charite, Univ. of Leipzig, INMED, INSERM, 

Sechenov IEPhB, RAS, Int. Ctr. for Mol. Physiology, NASU. 

10:00 H11 344.19 Translational regulation of astrocytic 

connexins and glutamine synthetase by cpebs. V. VANGOOR; 

S. TURIMELLA; J. ZHANG; L. KACZMARCZYK; P. BEDNER; 

E. V. STADEN; S. PASSLICK; S. HOEFT; A. DEROUICHE; 

R. JABS; G. SEIFERT*; C. STEINHÄUSER; M. THEIS. Univ. 

Bonn. 

11:00 H12 344.20 Calcium independent control of cerebral 

arteriole diameter by astrocytes via soluble adenylyl cyclase. 

G. R. GORDON*; H. B. CHOI; B. A. MACVICAR. Univ. of 


8:00 H13 344.21 Regulation of cortical interneuron function 

by metabolic substrates. L. BOZZO; J. CHATTON*. Univ. 

Lausanne. 

9:00 H14 344.22 • metabolic communication between 

astrocytes and neurons via bicarbonate-responsive soluble 

adenylyl cyclase. H. CHOI*; G. R. J. GORDON; C. TAI; N. 

ZHOU; J. K. RYU; J. G. MCLARNON; M. TRESGUERRES; 

L. R. LEVIN; J. BUCK; B. A. MACVICAR. Univ. of British 

Columbia, Weill Med. Col. of Cornell Univ. 

10:00 H15 344.23 The dystroglycan complex interacts 

with caveolin 1 and dynamin II and regulates aquaporin 4 

internalization in astrocytes. D. K. THAM*; H. MOUKHLES. 

Univ. of British Columbia. 

11:00 H16 344.24 Oxidative stress and astrocyte control of 

the vasculature. C. HOWARTH*; H. B. CHOI; G. C. R. ELLIS- 

DAVIES; B. A. MACVICAR. UBC Brain Res. Ctr., Mt Sinai 

Sch. of Med. 

8:00 H17 344.25 The isolation and physico-chemical 

characterization of rat brain cell nuclear membrane and 

cytosolic GlcNAc-specific lectin. R. AKHALKATSI*; T. 

MACHARADZE. Iv.Javakhishvili Tbilisi State University, 

Georgia. 

POSTER 

345. Neuron-Glia Interactions: Response to Cell Stress and 

Injury 


Mechanisms 


8:00 H18 345.1 DJ-1 expression modulates astrocytemediated 

neuroprotection in a complex I-specific manner. D. 

A. HINKLE*; S. J. MULLETT. Univ. Pittsburgh. 

9:00 H19 345.2 DJ-1 knock-down impairs astrocyte 

mitochondrial function. N. J. LARSEN*; G. AMBROSI; S. J. 

MULLETT; D. A. HINKLE. Univ. Pittsburgh. 

10:00 H20 345.3 Class 1 histone deacetylases (HDACs) are 

selectively expressed in axonal and glial cell compartments. 

S. P. MURPHY*; S. BALTAN; C. DANILOV; A. BACHLEDA; R. 

MORRISON. Univ. Washington Schl Med. 

11:00 H21 345.4 Class I histone deacetylase (HDAC) 

inhibitors preserve glial cell function and viability to 

protect white matter from ischemic injury. S. BALTAN*; 

S. P. MURPHY; C. A. DANILOV; A. BACHLEDA; R. S. 

MORRISON. Univ. Washington Sch. Med. 

8:00 H22 345.5 Neuron-astrocyte interaction is required for 

induction of Nrf2 antioxidant pathway by neuronal activity. A. 

M. HABAS*; J. HAHN; N. CHANDIRAMANI; M. MARGETA. 

UCSF. 

9:00 H23 345.6 Nrf2 modulation of NMDA receptor 

currents in primary hippocampal cultures. J. HAHN*; X. 

WANG; M. MARGETA. UCSF. 

10:00 H24 345.7 Chondroitin sulfate proteoglycan 

contributes to fixed anatomical deficit in chronic phase of 

stroke. J. HILL*; K. JIN; L. XIE; X. MAO; D. GREENBERG. 

Buck Inst. For Age Res. 

11:00 H25 345.8 Mechanisms for microglial engulfment 

and elimination of injured neuronal cells. T. KATAYAMA*; H. 

KOBAYASHI; T. OKAMURA; T. KIBAYASHI; M. MINAMI. Dept 

Pharmacol, Grad Sch. Pharm Sci, Hokkaido Univ. 



8:00 H26 345.9 Cell-autonomous and non-cellautonomous 

neuroprotective effects of the nuclear receptor 

RORalpha during cerebral hypoxia in cortical neurons and 

astrocytes. S. JOLLY*; N. JOURNIAC; F. NAUDET; O. 

CASES; V. GAUTHERON; J. MARIANI; B. VERNET-DER 

GARABEDIAN. Lab. NPA, CNRS UPMC, Inst. de la vision, 

Dept. of Neural development, Hôpital Charles Foix. 

9:00 H27 345.10 Regulated enzymatic production of 

astrocytic hydrogen peroxide induces neuroprotection from 

oxidative stress via an Nrf2 independent pathway. R. E. 

HASKEW-LAYTON*; J. B. PAYAPPILLY; N. SMIRNOVA; T. C. 

MA; K. K. CHAN; T. H. MURPHY; B. LANGLEY; R. SULTANA; 

D. A. BUTTERFIELD; S. SANTAGATA; I. GAZARYAN; G. W. 

BELL; R. R. RATAN. Burke/Cornell Med. Rese Inst., Burke/ 

Cornell Med. Res. Inst., Burke/Cornell Med. Res. Insitute, 

Univ. of British Columbia, Univ. of Kentucky, Whitehead Inst. 

of MIT. 

10:00 H28 345.11 Microglial toll-like receptor 2 contributes to 

kainic acid-induced glial activation and hippocampal neuronal 

cell death. I. CHO*; J. HONG; E. SUH; K. KWAK; J. SEO; 

S. CHOI; S. PARK; E. JO; S. LEE; K. LEE; S. LEE. Col. of 

Oriental Medicine, Kyung Hee Univ., Program in Mol. and Cell. 

Neuroscience, DRI, BK21, and Dept. of Oral Physiology, Sch. 

of Dentistry, Seoul Natl. Univ., Dept. of Pharmacology, Sch. 

of Medicine, Ewha Womans Univ., Dept. of Anatomy, Col. of 

Medicine, Konkuk Univ., Dept. of Microbiology and Infection 

Signaling Network Res. Center, Chungnam Natl. Univ. Col. 

of Med., Dept. of Microbiology, Sch. of Systems Biology, 

Chungnam Natl. Univ. 

11:00 H29 345.12 • Amplitude of ischemia-associated 

spreading depolarizations in adult rat brainstem after sudden 

severe hypoxia is not correlated to cardiovascular changes. F. 

RICHTER; A. LEHMENKUHLER*; R. BAUER; H. SCHAIBLE. 

Inst. of Physiol. I, Pain Inst. Dusseldorf, Inst. of Mol. Cell Biol. 

8:00 H30 345.13 • Swelling of astrocytes by gliotoxin delays 

diffusion in the extracellular space of rat neocortex. A. D. 

SHERPA*; P. VAN DE NES; F. XIAO; S. HRABETOVA. SUNY 

Downstate Med. Ctr. 

9:00 H31 345.14 • Releasing factors from mature neurons 

modulate microglial survival. K. FUKUI*; H. TAKATSU; S. 

URANO; T. KOIKE. Shibaura Inst. Technol., Hokkaido Univ., 

Universiti Industri Selangor. 

10:00 H32 345.15 Vulnerability of neurons to reduced supply 

of glial lactate: Dependence on level of neural activity. B. M. 

MORRISON*; Y. LI; A. TSINGALIA; C. COCCIA; E. YANG; 

S. LENGACHER; P. J. MAGISTRETTI; L. PELLERIN; J. D. 

ROTHSTEIN. Johns Hopkins Univ., Ecole Polytechnique 

Federale de Lausanne, Univ. de Lausanne. 

11:00 H33 345.16 Neurons that resist osmotic volume 

change in brain slices no longer resist when dissociated. N. 

RANEPURA; D. C. BRISSON; R. D. ANDREW*. Queen’s 

Univ. 

8:00 H34 345.17 Ethyl pyruvate-induced hemeoxygenase 

1 in astrocytes protects neurons against oxidative stress by 

enhancement of glial cell lined-derived neurotrophic factor. J. 

SHIN*; Y. JIN; I. KIM; H. KIM; P. HAN; J. LEE. Inha medical 

school, Ewha Womans university. 

9:00 H35 345.18 Characterization of astrocyte gliosis by 

microarray expression profiling reveals differing responses 

to brain insults. J. L. ZAMANIAN*; L. XU; N. NOURI; R. G. 

GIFFARD; B. A. BARRES. Stanford Univ., Stanford Univ. Sch. 

of Med. 

10:00 H36 345.19 Involvement of Rac1 in NMDA-induced 

neurotoxicity in the rat retina. K. C. SAITO; M. F. SANTOS; D. 

E. HAMASSAKI-BRITTO*. Inst. of Biomed. Sci. 



11:00 H37 345.20 Mechanisms of RGS10 regulation 

in microglia and neuroprotective effects of RGS10 

overexpression in a rat model of Parkinson’s disease. J. LEE*; 

J. CHUNG; I. TRAVENO; M. G. TANSEY. Emory Univ., UT 

Southwestern Med. Ctr. 

8:00 H38 345.21 Lipopolysaccharide injection causes 

prolonged microglial activation and depressive-like behavior in 

fractalkine receptor (CX 3 CR1)- deficient mice. A. M. WYNNE*; 

Y. HUANG; J. C. O’CONNOR; R. DANTZER; K. W. KELLEY; 

P. G. POPOVICH; J. P. GODBOUT. The Ohio State Univ., 

Univ. of Illinois. 

9:00 H39 345.22 Lps and hypoxia modulate synaptic 

plasticity. J. ZHANG*; B. A. MACVICAR. Univ. of British 

Columbia. 

10:00 H40 345.23 Partial microglial activation in rat entorhinal 

cortex following binge ethanol exposure. S. A. MARSHALL*; 

D. M. HOPKINS; J. R. PAULY; K. NIXON. Univ. of Kentucky. 

11:00 H41 345.24 NG2 progenitors are the main proliferative 

cells after corpus callosum demyelination and generate 

oligodendrocytes and astrocytes. T. R. HAMMOND*; V. 

GALLO; A. AGUIRRE. Childrens Natl. Med. Ctr., George 

Washington Univ., SUNY-Stony Brook. 

POSTER 

346. Inflammation and Neuron-Glia Interactions 



8:00 H42 346.1 Microglial cells search via Lévy flights, 

with increased run lengths after TNF-α or reduced neuronal 

activity. Y. Y. GRINBERG*; J. G. MILTON; R. P. KRAIG. Univ. 

of Chicago, The Claremont Colleges. 

9:00 H43 346.2 Inflammatory gene micro array profiling 

demonstrates “T-cell-like” activation after recurrent spreading 

depression - Implications for migraine pathogenesis. A. D. 

PUSIC*; R. P. KRAIG. Univ. of Chicago. 

10:00 H44 346.3 TNF-α increases spreading depression 

susceptibility via reduced GABAergic inhibition - Implications 

for the transformation of episodic to chronic migraine. H. M. 

MITCHELL; V. LEVASSEUR; R. P. KRAIG*. Univ. Chicago, 

Cornell Col. 

11:00 H45 346.4 Modulation of astrocyte P2Y signaling by 

inflammatory mediators. M. E. HAMBY*; G. COPPOLA; D. 

H. GESCHWIND; B. S. KHAKH; M. V. SOFRONIEW. Dept. 

of Neurobio. & Cousins Ctr. For Psychoneuroimmunology, 

UCLA. 

8:00 H46 346.5 In vivo two-photon imaging of interactions 

between macrophages/microglia and neurons in response to 

HIV Tat treatment in mouse cortex. S. LU*; D. F. MARKER; M. 

TREMBLAY; J. QI; A. K. MAJEWSKA; H. A. GELBARD. Univ. 

of Rochester Med. Ctr., Univ. of Rochester Med. center. 

9:00 H47 346.6 The opioid receptor antagonist, 

β-funaltrexamine, inhibits inflammatory signaling. R. L. 

DAVIS*; D. J. BUCK; S. ARAVIND; C. W. STEVENS. 

Oklahoma State Univ. Ctr. Hlth. Sci. 

10:00 H48 346.7 Pharmacologic inhibition of mixed lineage 

kinase 3 reduces neuroinflammation and neuronal pathology 

in mice exposed to human immunodeficiency virus type 1 

trans-activator of transcription protein. D. F. MARKER*; S. LU; 

M. TREMBLAY; A. K. MAJEWSKA; H. A. GELBARD. Univ. of 

Rochester. 


Mon. AM

11:00 H49 346.8 Opioid agonists and antagonists alter 

toll-like receptor-4 (TLR4) signaling. C. W. STEVENS*; S. 

ARAVIND; R. L. DAVIS. OSU-Center For Hlth. Sci. 

8:00 H50 346.9 • Reactive gliosis and invasion of activated 

microglia, in a animal model of Experimental Autoimmune 

Glaucoma. S. C. JOACHIM*; O. W. GRAMLICH; V. D. STAHL; 

P. F. GOTTSCHLING; C. CUNY; N. PFEIFFER; F. H. GRUS. 

Exptl. Ophthalmology. 

9:00 H51 346.10 GABA is synthesized by astrocytes 

at comparable levels to inhibitory neurons and has an 

antiinflammatory effect on astrocytes and microglia. P. L. 

MCGEER; E. G. MCGEER*; M. LEE; C. SCHWAB. Univ. 


10:00 H52 346.11 STAT3 inhibitors reduce human astrocytic 

neurotoxicity. S. HASHIOKA*; A. KLEGERIS; P. L. MCGEER. 

Univ. British Columbia, Univ. British Columbia Okanagan. 

11:00 H53 346.12 Intracellular Ca 2+ dynamics underlying 

ATP-induced TNFα release in MG5 microglial cells. S. 

TSUNO; M. IKEDA; T. YOSHIOKA; T. SUGIYAMA*. Grad. 

Sch. of Sci. and Engineering, Univ. of Toyama, Ctr. of 

Excellent for Envrn. Medicine, Grad. Inst. of Med. Sciences, 

Kaohsiung Med. Univ., Olympus Corp. 

8:00 H54 346.13 Involvement of superoxide anion in the 

induction of TNFα in microglia. K. NAKAJIMA*; Y. YOSHINO; 

Y. TOHYAMA; S. KOHSAKA. Soka Univ., Natl. Inst. of 

Neurosci. 

9:00 H55 346.14 Prostaglandin modulates the TLR3induced 

cytokine expression in human astroglioma CRT-MG 

cells. J. SEO; K. LEE; C. PARK; S. JO; S. OH; K. PARK; J. 

KIM; S. LEE; S. CHOI*. Seoul Natl. Univ., Kangwon Natl. Univ. 

10:00 H56 346.15 Microglial peroxiredoxin V acts as an 

inducible anti-inflammatory antioxidant through cooperation 

with redox signaling cascades. D. LEE*; H. CHOI; S. KIM. 

Kyungpook Natl. Univ., Natl. Primate Res. Center, Korea Res. 

Inst. of Biosci. and Biotech. (KRIBB). 

11:00 H57 346.16 • Trigeminal satellite cells and cortical 

astrocytes express functional calcitonin gene-related peptide 

receptor, whose activation enhances glial responses to 

interleukin-1β. A. DE CORATO; L. LISI; A. CAPUANO; G. 

TRINGALI; P. NAVARRA; C. DELLO RUSSO*. Univ. Cattolica 

S.Cuore. 

8:00 H58 346.17 Expression of signaling molecules and 

receptors implicated in central sensitization is increased 

by calcitonin gene-related peptide in cultured astrocytes 

and microglia. J. STRIDER; C. V. VAUSE*; P. L. DURHAM. 

Missouri State Univ. 

POSTER 

347. Tau: Role of Aggregated and Soluble Tau in Animal 

Models 



8:00 H59 347.1 A novel transgenic model with humanized 

splicing of Tau Exon 10. A. GUMUCIO*; L. LANNFELT; L. N. 

G. NILSSON. Rudbeck Laboratory, Publ. Hlth. and Caring 

Sciences, Uppsala Univ. 

9:00 H60 347.2 Biochemical characterization of protein 

degradation pathways in a transgenic mouse model of Tau 

pathology (THY-Tau22). M. HAMDANE*; J. DESMERCIÈRES; 

C. LAURENT; S. BURNOUF; L. TROQUIER; A. 

LEBOUCHER; D. DEMEYER; S. BECQUE; M. E. 

GROSJEAN; R. CAILLIEREZ; I. BRION; F. FERNANDEZ- 

GOMEZ; N. SERGEANT; D. BLUM; L. BUEE. INSERM U837, 

Alzheimer & Tauopathies, USDL, Faculte De Medecine-Pole 

Recherche, Univ. Lille Nord de France, JParc, IMPRT, CHU- 

Lille. 

10:00 H61 347.3 Impairment of BDNF-mediated 

hippocampal synaptic facilitation in a transgenic model 

of Alzheimer’s disease-like Tau pathology. D. BLUM*; S. 

BURNOUF; A. MARTIRE; K. BELARBI; C. LAURENT; A. 

MUHR-TAILLEUX; A. VAN DER JEUGD; A. LEBOUCHER; 

F. FERNANDEZ-GOMEZ; L. TROQUIER; M. GROSJEAN; 

D. DEMEYER; J. BRION; A. BUISSON; R. D’HOOGE; N. 

SERGEANT; S. HUMEZ; M. HAMDANE; P. POPOLI; L. 

BUÉE. Inserm U837, ISS, Inserm U1011, Katholieke Univ. 

Leuven, ULB, Univ. de Caen Basse-Normandie. 

11:00 H62 347.4 In vivo microdialysis assessment of brain 

interstitial fluid tau levels. K. YAMADA*; J. R. CIRRITO; L. I. 

BINDER; V. M. LEE; D. M. HOLTZMAN. Washington Univ., 

Northwestern Univ., Chicago, Univ. of Pennsylvania. 

8:00 H63 347.5 • Dimebon improves spatial learning and 

reduces phospho-Tau (Thr231)/total Tau ratio in TAU441 

transgenic mice. A. A. PROTTER*; M. GIORGETTI; M. 

MITROVIC; S. DULLER; R. RABL; B. HUTTER-PAIER. 

Medivation, JSW Life Sci. 

9:00 H64 347.6 • Analysis of gene expression in the 

hippocampal subfields of Tg4510 and CAMKIIα-tTA 

transgenic mice. P. D. WES*; A. EASTON; M. A. SEAGER; N. 

X. BARREZUETA; C. BOURIN; J. HOGAN; A. TRUONG; A. 

HE; D. BARTON; A. M. CACACE. Bristol-Myers Squibb. 

10:00 H65 347.7 • Imbalanced expression of tau and 

tubulin may be a determinant of the tauopathy cascade. T. 

MIYASAKA*; Y. SHINZAKI; S. YOSHIMURA; S. YOSHINA; 

E. KAGE-NAKADAI; S. MITANI; Y. IHARA. Doshisha Univ., 

Tokyo Women’s Med. Univ. Sch. of Medicine, Dept. of Physiol. 

11:00 H66 347.8 Factors responsible for neurofibrillary 

tangle formation and neuronal cell loss in tauopathy brains. 

T. KAWARABAYASHI*; Y. WAKASAYA; M. WATANABE; Y. 

YAMAMOTO-WATANABE; A. TAKAMURA; E. MATSUBARA; 

M. SHOJI. Hirosaki Univ. Grad. Sch. of Med. 

8:00 H67 347.9 Role of glucocorticoids in the development 

of neuropathology in mouse models of both Alzheimer’s 

disease and related tauopathies. J. C. CARROLL*; M. IBA; J. 

Q. TROJANOWSKI; V. M. LEE. Univ. of Pennsylvania. 

9:00 H68 347.10 Regulation of tau aggregates via 

autophagy. W. YU*; H. Y. F. FIGUEROA; M. J. HERMAN; K. 

E. K. DUFF. Columbia Univ., Res. Fndn. for Mental Hyg. 

10:00 H69 347.11 Modulation of tau oligomers by passive 

vaccination. D. L. CASTILLO*; C. LASAGNA-REEVES; M. 

J. GUERRERO-MUNOZ; D. M. ESTES; A. BARRETT; K. 

DINELEY; G. R. JACKSON; R. KAYED. UTMB. 

11:00 H70 347.12 Loss of tau protects against APP 

intracellular domain (AICD)-induced Alzheimer’s pathological 

features. K. GHOSAL*; Q. FAN; H. N. DAWSON; S. W. 

PIMPLIKAR. Cleveland Clinic, LRI, Duke Univ. 

8:00 I1 347.13 Endogenous tau reduction ameliorates 

Aβ-induced impairments in axonal transport. K. A. VOSSEL; 

K. ZHANG; X. WANG; G. YU; K. HO; B. CUI; L. MUCKE*. 

Gladstone Inst. of Neurolog. Dis., Stanford Univ., Univ. Calif 

San Francisco. 



9:00 I2 347.14 P73 and Alzheimer disease are not 

associated in a transgenic model or in human cohorts. D. 

VERGOTE*; B. VARDARAJAN; M. LOGUE; J. YANG; E. 

ROGAEVA; J. LEE; R. CHENG; M. GHANI; B. SHI; C. T. 

BALDWIN; S. KAR; R. MAYEUX; P. FRASER; L. A. FARRER; 

D. WESTAWAY. Univ. Alberta, Boston Univ. Sch. of Med., 

Univ. of Toronto, Columbia Univ. 

10:00 I3 347.15 Map tau mediates LTP inhibition after low 

frequency stimuli in wild type mouse brain. T. KIMURA*; S. 

YAMASHITA; M. MURAYAMA; T. MIZOROKI; A. TAKASHIMA. 

RIKEN. 

11:00 I4 347.16 Exposure of the N-terminal phosphataseactivating 

domain of tau: Implications in axonal transport 

dysfunction and disease pathogenesis. N. M. KANAAN*; G. 

MORFINI; Y. FU; S. BRADY; L. BINDER. Northwestern Univ., 

Univ. of Illinois at Chicago. 

8:00 I5 347.17 Characterization of tau oligomers and the 

role of Hsp70 in tau oligomerization. K. R. PATTERSON*; 

N. M. KANAAN; M. J. GLUCKSMAN; T. C. GAMBLIN; L. I. 

BINDER. Northwestern Univ., RFUMS/Chicago Med. Sch., 

Univ. of Kansas. 

9:00 I6 347.18 • Accurate measurement of CSF tau in 

transgenic mice. D. M. BARTEN*; L. YANG; G. CADELINA; N. 

HOQUE; L. DECARR; V. GUSS; S. SANKARANARAYANAN; 

J. MEREDITH; M. AHLIJANIAN; C. F. ALBRIGHT. Bristol- 

Myers Squibb. 

10:00 I7 347.19 Pseudohyperphosphorylation mutations 

in tau isoforms affect polymerization and interaction with 

microtubules. B. COMBS*; K. VOSS; T. C. GAMBLIN. Univ. of 

Kansas. 

11:00 I8 347.20 Progression of tau pathology in cholinergic 

nucleus basalis neurons in MCI and AD. L. C. VANA*; N. 

M. KANAAN; I. C. UGWU; E. J. MUFSON; L. I. BINDER. 

Northwestern Univ., Rush Univ. 

8:00 I9 347.21 Increased tau pathology in type 2 

diabetes mouse model. N. EL KHOURY*; F. MARCOUILLER; 

M. PAPON; F. MORIN; E. PLANEL*. Ctr. Hospitalier De 

L’Université Laval. 

9:00 I10 347.22 Heat shock protein 70 alters tau isoform 

functions in vitro. K. VOSS*; B. COMBS; T. C. GAMBLIN. 

Univ. of Kansas. 

10:00 I11 347.23 Mitochondrial mislocalization in a 

mouse model of tauopathy (rTg4510). K. J. KOPEIKINA*; 

R. PITSTICK; G. A. CARLSON; T. L. SPIRES-JONES; B. 

T. HYMAN. Boston Univ. Sch. of Med., MassGeneral Inst. 

for Neurodegenerative Dis. at Massachusetts Gen. Hosp., 

McLaughlin Res. Inst., Harvard Med. Sch. 

11:00 I12 347.24 Role of tau function in cognitive 

deficits in Alzheimer model mice. D. J. GANT; F. YANG; M. 

ALAVERDYAN; Q. MA; G. M. COLE; S. A. FRAUTSCHY*. 

UCLA, Cedars-Sinai Med. Ctr. 

8:00 I13 347.25 • Synaptic mitochondria from a tauopathy 

model of AD have increased mass and membrane potential. 

K. HENKINS*; M. ALAVERDYAN; S. FRAUTSCHY; G. COLE; 

C. MILLER; H. VINTERS; K. GYLYS. UCLA, Sepulveda 

VAMC GRECC, UCLA Sch. of Med. and Sepulveda VAMC 

GRECC, Keck USC Sch. of Med., UCLA Sch. of Nursing and 

Brain Res. Inst. 

9:00 I14 347.26 Spread of tauopathy and its functional 

impacts in transgenic mice with entorhinal cortex restricted 

expression of mutant human tau. L. LIU*; S. SMALL; K. DUFF. 

Columbia Univ. 



10:00 I15 347.27 • Biochemical characterisation of tau 

pathology in the P301S mouse model. S. J. GLOVER*; J. 

WOLAK; T. K. MURRAY; C. V. CELLA; R. PURCELL; N. 

BUCKNER; M. J. O’NEILL; V. LAKICS; I. LAVENIR; M. 

GOEDERT; P. DAVIES; M. L. HUTTON; P. G. SZEKERES. Eli 

Lilly and Co. Ltd, MRC, Albert Einstein Col. of Med. 

11:00 I16 347.28 • Tau histopathology and 

neurodegeneration in rTg4510 mice depend on genetic 

background. J. N. MARCUS*; A. HUGHES; R. KENNAN; 

C. WOLFFE; M. PEARSON; X. WANG; J. RENGER; M. 

SAVAGE. Merck Res. Labs. 

8:00 I17 347.29 • Exploring tauopathies in transgenic 

zebrafish by in vivo imaging. D. PAQUET; G. PLUCINSKA; 

L. GODINHO; T. MISGELD; R. BHAT; E. MANDELKOW; 

B. SCHMID; C. HAASS*. DZNE - German Ctr. for 

Neurodegenerative Dis., TU Munich, AstraZeneca R&D, Max- 

Planck Unit for Structural Mol. Biol. at DESY, Adolf Butenandt 

Inst, LMU. 

9:00 I18 347.30 • Prominent neuroinflammation in the 

Tg4510 tauopathy model revealed by transcriptional profiling. 

J. P. CORRADI*; L. YANG; N. HOQUE; P. POUNDSTONE; 

V. PATEL; L. DECARR; C. ANDORFER; A. M. CACACE; D. 

BARTEN. Bristol-Myers Squibb Co., Mayo Clin. 

POSTER 

348. Aging: Animals and humans 



8:00 I19 348.1 • Serum antibody biomarkers for 

Alzheimer’s disease. D. C. GERMAN*; R. DIAZ-ARRASTIA; 

M. REDDY; J. WILSON; R. WILSON; T. KODADEK. U Texas 

Southwestern Med. Cntr., The Scripps Res. Inst. 

9:00 I20 348.2 GAMMA suite: an open source cross 

platform Bayesian data-mining software package for 

neuroimaging structure-function analysis. R. CHEN; 

E. HERSKOVITS*. Univ. of Pennsylvania, university of 

pennsylvania. 

10:00 I21 348.3 Influence of viral vector-mediated delivery 

of superoxide dismutase and catalase to the hippocampus 

on spatial learning and memory over the course of aging. W. 

LEE*; A. KUMAR; A. RANI; J. HERRERA; T. FOSTER. Univ. 

Florida. 

11:00 I22 348.4 Caudate atrophy & its clinical correlates in 

400 Alzheimer’s disease, MCI, & healthy elderly subjects. S. 

K. MADSEN*; A. J. HO; X. HUA; P. S. SAHARAN; C. R. JACK 

JR.; M. W. WEINER; A. W. TOGA; P. M. THOMPSON. UCLA, 

Mayo Clin. Col. of Med., UCSF. 

8:00 I23 348.5 Hysterectomy is associated with increased 

brain ferritin iron levels. T. A. TISHLER*; E. P. RAVEN; P. 

H. LU; C. P. AMAR; N. R. DETORE; L. L. ALTSHULER; G. 

BARTZOKIS. UCLA. 

9:00 I24 348.6 Common Alzheimer’s disease risk variant 

within the CLU gene affects white matter microstructure in 

young adults. M. N. BRASKIE*; N. JAHANSHAD; J. L. STEIN; 

M. BARYSHEVA; K. L. MCMAHON; G. I. DE ZUBICARAY; N. 

G. MARTIN; M. J. WRIGHT; J. M. RINGMAN; A. W. TOGA; 

P. M. THOMPSON. Univ. California Los Angeles, Univ. of 

Queensland, Queensland Inst. of Med. Res. 


Mon. AM

10:00 I25 348.7 • Age related alterations of kynurenine 

aminotransferase I, II and III activities. B. KEPPLINGER*; 

H. BARAN; K. STANIEK; M. BERTIGNOL; M. ATTAM; 

B. SEDLNITZKY-SEMLER. Karl Landsteiner Institut, Nö 

Landesklinikum Mauer, NÖ Landesklinikum Mauer, Karl 

Landsteiner Institut, NÖ Landesklinikum Mauer, Vet. Med. 

Univ. 

11:00 I26 348.8 Cardiovascular fitness in apoe-e4 carriers 

is associated with altered cerebral glucose metabolism during 

the Sternberg working memory task. J. WINCHESTER*; S. 

DEENY; C. COTMAN. Inst. For Memory Impairments and 

Neurolog. Disorders, Univ. of California, Irvine, Schafer Corp. 

8:00 I27 348.9 • Effects of aging on ultrasonic vocalization 

and motoneurons in the nucleus ambiguus in rats. J. N. 

SHIER; N. P. CONNOR; M. R. CIUCCI*. Univ. Wisconsin, 

Univ. of Wisconsin. 

9:00 I28 348.10 • Influence of tryptophan metabolites on 

the respiratory parameters of rat brain mitochondria during 

aging. H. BARAN*; K. STANIEK; M. BERTIGNOL; M. ATTAM; 

B. KEPPLINGER. Karl Landsteiner Res. Inst. Mauer, Vet. 

Med. Univ., NÖ Landesklinikum Mauer, NÖ Landesklinikum 

Amstetten. 

10:00 I29 348.11 DNA hypomethylation in the nervous 

system during aging is region specific and influenced by 

gender. A. FAHLSTRÖM*; M. KARIMI; T. J. EKSTRÖM; B. 

ULFHAKE. Karolinska Institutet. 

11:00 I30 348.12 Cerebral amyloid angiopathy in 

centenarians. T. IWASE*; Y. HASHIZUME; M. YOSHIDA; 

K. OJIKA. Nagoya City Koseiin Med. Welfare Ctr., Inst. for 

Neuropathology, Fukushimura Hosp., Inst. for Med. Sci. of 

Aging, Aichi Med. Univ., Nagoya City Univ. 

8:00 I31 348.13 Imaging brain amyloid in adults with 

Down syndrome with Pittsburgh Compound-B. J. LANDT; A. 

J. HOLLAND; J. D’ABRERA; J. BARON; F. AIGBIRHIO; T. 

FRYER; R. CANALES; Y. HONG; D. MENON; S. H. ZAMAN*. 

Univ. of Cambridge. 

9:00 I32 348.14 Quantification of markers of DNA and 

RNA oxidation in the progression of Alzheimer’s disease (AD). 

M. A. BRADLEY; M. D. TIMMONS; B. C. LYNN, Jr.; W. R. 

MARKESBERY; M. A. LOVELL*. Univ. Kentucky. 

10:00 I33 348.15 Inflammation-related cytokines and 

chemokines are dissociatively associated with age-induced 

atrophy in cortex and hippocampus and are jointly mitigated 

by calorie restriction in rhesus macaques. A. A. WILLETTE*; 

B. BENDLIN; A. SODHI; E. KASTMAN; D. MCLAREN; K. 

KOSMATKA; C. COE; S. JOHNSON. Univ. of Wisconsin 

- Madison, Univ. of Wisconsin-Madison, Univ. of Wisconsinmadison. 

11:00 I34 348.16 Pericyte deficiency leads to cerebral 

vascular disruption causing secondary neurodegenerative 

changes. R. D. BELL*; A. SAGARE; E. A. WINKLER; I. 

SINGH; R. DEANE; B. V. ZLOKOVIC. Univ. of Rochester. 

8:00 I35 348.17 • Microarray study of multiple regions 

of human brain reveals new concepts of synaptic change 

in aging and Alzheimer’s disease. P. D. COLEMAN*; N. 

BERCHTOLD; D. CRIBBS; A. GROVER; J. ROGERS; C. W. 

COTMAN. Sun Hlth. Res. Inst., Univ. of California, Irvine, UC 

Irvine. 

9:00 I36 348.18 Immune-related gene expression 

is modulated by age, AD, and ApoE genotype in the 

human brain: Microarray findings. N. C. BERCHTOLD*; 

D. H. CRIBBS; V. PERREAU; E. HEAD; P. COLEMAN; J. 

ROGERS; C. W. COTMAN. Univ. California Irvine, Univ. of 

Melbourne, Univ. of Kentucky, Sun Hlth. Res. Inst. 

10:00 I37 348.19 Alterations in 5-methylcytidine and DNA 

methyltransferase 3a immunoreactivity in the aging mouse 

hippocampus; differential effects of caloric restriction and 

SOD1 genotype. L. CHOULIARAS*; D. L. A. VAN DE HOVE; 

G. KENIS; J. VAN OS; H. W. M. STEINBUSCH; B. P. F. 

RUTTEN. Maastricht University, Sch. For Mental Hlth. and 

Neurosci. 

11:00 I38 348.20 In vivo proton and phosphorous magnetic 

resonance spectroscopy (MRS) studies on alzheimer and MCI 

subjects of indian cohorts. P. K. MANDAL*; M. TRIPATHI; M. 

AHUJA. Nat’l Brain Res. Ctr., AIIMS. 

8:00 I39 348.21 • Correspondence between in vivo PiB- 

PET amyloid imaging and post-mortem, regional burden of 

A-beta, but not Tau lesions. I. DRISCOLL*; J. C. TRONCOSO; 

J. SOJKOVA; Y. ZHOU; G. RUDOW; C. DAVATZIKOS; M. A. 

KRAUT; L. FERRUCCI; C. A. MATHIS; W. E. KLUNK; D. F. 

WONG; R. O’BRIEN; S. M. RESNICK. Natl. Inst. on Aging/ 

NIH, Johns Hopkins Med. Institutions, Univ. of Pennsylvania, 

Univ. of Pittsburgh. 

9:00 I40 348.22 Excitability of glial cells and their 

interactions with synapses are altered during aging. A. ST- 

AMOUR*; J. VALLÉE; R. ROBITAILLE. Univ. de Montréal, 

group GRSNC of FRSQ. 

10:00 J1 348.23 Dramatic loss of Ube3A expression during 

aging of the mammalian cortex. K. WILLIAMS*; D. A. IRWIN; 

D. G. JONES; K. M. MURPHY. McMaster Univ. 

11:00 J2 348.24 � Effects of 670 nm light therapy and 

paraquat consumption on longevity and oxidative stress in 

Drosophila melanogaster. S. S. GREEN; J. P. PETERSON; A. 

SAKHARUK; P. B. HAMOY; D. J. BAUER*. Viterbo Univ. 

8:00 J3 348.25 � Progression of brain atrophy and 

white matter disease in normal aging and mild-moderate 

Alzheimer’s disease. N. H. NEUFELD*; J. RAMIREZ; C. 

J. M. SCOTT; N. LEVY-COOPERMAN; S. E. BLACK. L.C. 

Campbell Cognitive Neurol. Res. Unit, Sunnybrook Hlth. Sci. 

Ctr., Univ. of Toronto, Heart and Stroke Fndn. Ctr. for Stroke 

Recovery. 

9:00 J4 348.26 NCAM is important for retinal ganglion 

cell function throughout aging. P. LUKE*; T. L. LEVATTE; 

A. O’REILLY; F. TREMBLAY; R. BROWN; D. B. CLARKE. 

Dalhousie Univ. 

POSTER 

349. Old Age Markers of Pathology 



8:00 J5 349.1 Bdnf transcription in the hippocampus 

is uniquely impaired by age and peripheral infection. T. 

CHAPMAN*; R. M. BARRIENTOS; J. HOOVER; J. T. 

AHRENDSEN; S. F. MAIER; S. L. PATTERSON. Univ. of 

Colorado. 

9:00 J6 349.2 The effect of AIRAP on modulating 

proteasome activity in the nervous system of Drosophila. S. 

TEEGALA*. 

10:00 J7 349.3 • Fractal analysis of the cerebral cortex 

in Alzheimer’s disease. B. BROWN; J. BERBERICH; R. D. 

KING*. Univ. of Utah. 

11:00 J8 349.4 Characterization of phosphodiesterase 

(PDE) family transcripts in rodent brain and spinal cord. W. O. 

ADAMOWICZ*; S. E. BOVE; A. ROMEGIALLI; A. MARIGA; R. 

J. KLEIMAN. Pfizer, Univ. of Connecticut Sch. of Med. 



8:00 J9 349.5 Backgroung levels of mercury in housed 

monkeys. K. HALLOCK*; D. ROSENE; P. BERGETHON. 

Boston Univ. Sch. of Med. 

9:00 J10 349.6 Glia-neuron interaction in the 

hippocampus of the rat is modified by aging and inflammation. 

M. GIOVANNINI*; F. CERBAI; D. LANA; A. PUGLIESE; D. 

NOSI; G. WENK. Univ. 

10:00 J11 349.7 Maternal separation compromises LTP 

and spatial reference memory in aged rats. L. V. LOPES*; A. 

COSTENLA; J. VITAL; A. M. SEBASTIÃO. Neurosci Unit and 

Inst. Pharmacol Neurosci, IMM, Fac Med. Lisbon. 

11:00 J12 349.8 The effects of neonatal cholinergic lesion 

on age-related changes in behaviour, neurogenesis and CA1 

pyramidal cell morphology. K. E. RENNIE*; M. FRECHETTE; 

B. A. PAPPAS. Carleton Univ. 

8:00 J13 349.9 • Interference from heterophilic antibodies 

in Aβ oligomer ELISAs. S. SÖLLVANDER; D. SEHLIN; S. 

PAULIE; R. BRUNDIN; M. INGELSSON; L. LANNFELT*; 

F. EKHOLM PETTERSSON; H. ENGLUND. Uppsala Univ., 

Mabtech AB. 

9:00 J14 349.10 High-throughput screen for drugs targeting 

calciumopathy in familial Alzheimer’s disease associated with 

presenilin mutations. K. HONARNEJAD*; A. SZYBINSKA; 

J. KUZNICKI; J. HERMS. Ctr. For Neuropathology, Exptl. 

Neuropathology Lab, Univ. of Munich, Intl. Inst. of Mol. and 

Cell Biol. 

10:00 J15 349.11 Determination of a-beta species in human 

cerebrospinal fluid using different methods. C. G. SCHIPKE*; 

S. PROKOP; F. HEPPNER; I. HEUSER; O. PETERS. Charité 

Berlin, Charité Univ. Med. Berlin. 

11:00 J16 349.12 Changes of hippocampal metabolic 

connectivity with increase of clinical severity in Alzheimer’s 

disease. S. CHO; E. KIM; E. YOON; S. BANG; H. PARK; D. 

NA; S. KIM*. Seoul Natl. Univ. Coll Med., Pusan Natl. Univ. 

Sch. of Med. and Med. Res. Inst., Samsung Med. Center, 

Sungkyunkwan Univ. Sch. of Med. 

8:00 J17 349.13 Effects of the lipid environment on 

the plasma membrane Ca2+-ATPase localized in raft 

microdomains. L. JIANG*; M. D. BECHTEL; J. L. BEAN; M. L. 

MICHAELIS. Univ. Kansas. 

9:00 J18 349.14 Altered redox state contributes to 

increased afterhyperpolarization of hippocampal CA1 

pyramidal neurons during senescence: Role for ryanodine 

receptor oxidation. A. KUMAR; K. BODHINATHAN; T. C. 

FOSTER*. McKnight Brain Inst. Univ. Florida. 

10:00 J19 349.15 Lack of high affinity nicotinic acetylcholine 

receptors decreases the number of GABAergic interneurons 

but not synaptic density in the hippocampal region of aged 

mice. P. HUANG*; L. C. ABBOTT; U. H. WINZER-SERHAN. 

Texas A&M Univ., Texas A&M Hlth. Sci. Ctr. 

11:00 J20 349.16 • Behavioral enrichment (ENR) and/or a 

diet enriched in mitochondrial cofactors/antioxidants (AOX) 

attenuates caspase activation in the aged canine brain. S. 

SNIGDHA*; N. W. MILGRAM; C. COTMAN. Inst. For Memory 

Impairments and Neurolog. Disorders, CanCog Technologies. 

8:00 K1 349.17 Parkin targets common pathways to 

attenuate the pathologic effects of Aβ 1-42 , α-Synuclein and 

Tau in gene transfer animal models. C. E. MOUSSA*; W. G. 

REBECK. Georgetown Univ. 

9:00 K2 349.18 Protective effect of curcuminoids on age- 

associated alterations in nitric oxide synthase activity and 

mitochondrial dysfunction. M. RASTOGI*; R. P. OJHA; S. 

K. SHANKAR; A. MAHADEVAN; C. SAGAR; G. P. DUBEY. 

SASTRA Univ., NIMHANS. 



10:00 K3 349.19 Immunomarkers of GABAergic basal 

forebrain projection neurons are selectively elevated in 

cognitively-impaired aged F344 rats. C. BANUELOS*; C. 

L. LASARGE; J. J. HARTMAN; B. T. AMBROSE; B. C. 

GAGLIANO; J. M. GRAHAM; R. J. GILBERT; J. L. BIZON. 

Texas A&M Univ., Univ. of Florida. 

11:00 K4 349.20 S100A1-/- mice have attenuated 

odor detection abilities. G. A. EDWARDS*, III; K. S. 

MONTGOMERY; S. L. WILSON; D. B. ZIMMER; E. 

ROLTSCH; J. L. BIZON. Univ. of Florida, Texas A&M Univ. 

8:00 K5 349.21 Baclofen-mediated GTP-binding is 

decreased in the prefrontal cortex, but not hippocampus, 

of aged F344 rats. J. A. MCQUAIL*; C. BAÑUELOS; C. L. 

LASARGE; R. J. GILBERT; J. L. BIZON; M. M. NICOLLE. 

Wake Forest Univ., Texas A&M Univ. 

9:00 K6 349.22 Development of a novel, translational 

hippocampal-dependent learning assessment: Implications 

for early diagnosis of Alzheimer’s Disease. K. S. 

MONTGOMERY*; G. EDWARDS, III; D. MATHAI; K. 

BURTON; B. SETLOW; J. L. BIZON. Texas A&M Univ. 

10:00 K7 349.23 Loss of hypothalamic orexin/hypocretin 

neurons in aged rats. J. R. FADEL*; B. A. KESSLER; E. M. 

STANLEY; D. FREDERICK-DUUS. Univ. of South Carolina 

Sch. of Med. 

11:00 K8 349.24 Aging-induced changes in orexin/ 

hypocretin modulation of septo-hippocampal connectivity. E. 

M. STANLEY*; J. R. FADEL. Univ. of South Carolina Sch. of 

Med. 

8:00 K9 349.25 Age-related changes in activation of 

orexin/hypocretin projections to insular cortex and ventral 

tegmental area by food deprivation. J. M. HAGAR*; J. A. 

FORD; J. R. FADEL. Univ. of South Carolina Sch. of Med. 

9:00 K10 349.26 • Patterns of cortical and subcortical 

neuroanatomical change identified in posterior cortical 

atrophy using baseline and longitudinal volumetric magnetic 

resonance imaging. E. J. KAESTNER; M. S. RAFII; M. JIN; 

C. TAYLOR; D. HOLLAND; D. J. HAGLER; A. M. DALE; J. B. 

BREWER*. UCSD. 

10:00 K11 349.27 • Patterns of cortical and subcortical 

atrophy identified in Parkinson’s disease dementia and 

dementia with Lewy bodies using volumetric and diffusion 

tensor imaging. E. A. MURPHY*; T. M. SEIBERT; E. J. 

KAESTNER; D. HOLLAND; D. J. HAGLER, Jr.; A. M. DALE; 

J. B. BREWER. UC San Diego. 

11:00 K12 349.28 • Resting-state BOLD correlations 

in Parkinson’s disease dementia. T. M. SEIBERT*; E. A. 

MURPHY; E. J. KAESTNER; D. J. HAGLER, Jr.; J. B. 

BREWER. Univ. California San Diego. 

POSTER 

350. Epilepsy: Epileptogenesis I 



8:00 K13 350.1 • Electrographic correlates of 

epileptogenesis in pilocarpine and kainic acid models of 

chronic epilepsy. F. KHEIRI; J. ALMAJANO; J. ENGEL, Jr; A. 

BRAGIN*. David Geffen Sch. Med. UCLA. 


Mon. AM

9:00 K14 350.2 Alterations in seizure threshold to 

the GABAA receptor antagonist pentylenetetrazole after 

pilocarpine-induced status epilepticus. M. RATTKA; C. 

BRANDT; M. BANKSTAHL; S. BRÖER; W. LOSCHER*. Univ. 

of Vet. Med. 

10:00 K15 350.3 Urokinase-type plasminogen activator 

receptor modulates epileptogenesis in mouse model 

of temporal lobe epilepsy. X. E. NDODO-EKANE*; A. 

PITKÄNEN. A.I.V Inst., A.I.V Institute, Univ. of Eastern 

Finland. 

11:00 K16 350.4 Time-dependent enhancement of estrogen 

receptors expression in the hippocampus and neocortex 

of rats following pilocarpine-induced status epilepticus. N. 

DE-MELLO*; C. P. FIGUEIREDO; R. M. LINHARES; V. L. 

ANTUNES; M. SCHWARZBOLD; A. P. B. BATSCHAUER; G. 

DI GIUNTA; T. L. MAZZUCO; R. D. S. PREDIGER; R. WALZ. 

Rua Airton Schaffer, 144 Ap 103, Univ. do Sul de Santa 

Catarina, Univ. Federal de Santa Catarina. 

8:00 K17 350.5 Changes in gene expression of 

presynaptic proteins after pathologically increased synaptic 

activity and during epileptogenesis. T. MITTELSTAEDT*; M. 

ROYECK; A. BECKER, MD; S. SCHOCH. Univ. of Bonn Med. 

Ctr. 

9:00 K18 350.6 Local neurometabolic coupling 

surrounding a seizure focus in rat neocortex. M. ZHAO*; H. 

MA; E. DE LA CRUZ; T. H. SCHWARTZ. Weill Cornell Med. 

Col. 

10:00 K19 350.7 • Glutamate release by kindling electrical 

stimulation. C. SANDOVAL SALAZAR*; A. MORALES- 

VILLAGRAN; J. ORTEGA-IBARRA; V. PALOMERA-AVALOS. 

Univ. de Guadalajara. 

11:00 K20 350.8 A role for synaptic calcium signaling 

in compensatory responses to hippocampal network 

hyperexcitability. J. R. CASANOVA*; J. T. LE; T. T. LAM; J. W. 

SWANN. Baylor Col. of Med., Texas Children’s Hosp. 

8:00 L1 350.9 Do seizures result in altered properties of 

layer 5 pyramidal cells in rodent sensorimotor cortex? J. A. 

BOYCHUK*; Q. J. PITTMAN; G. C. TESKEY. Univ. of Calgary. 

9:00 L2 350.10 Dendritic HCN downregulation alters 

cellular and network excitability in freeze-induced cortical 

dysplasia. A. ALBERTSON; J. YANG; J. J. HABLITZ*. Univ. 

Alabama Birmingham. 

10:00 L3 350.11 Sprouted mossy fiber synapses 

preferentially form onto newborn cells in a rodent model of 

temporal lobe epilepsy. A. L. ALTHAUS*; M. M. KRON; H. 

ZHANG; N. E. KRANZ; J. M. PARENT. Univ. of Michigan. 

11:00 L4 350.12 Increased phosphorylation of GluR1 

Ser831 and Ser845 following pentylenetetrazol induced 

neonatal seizures: Role in epileptogenesis. S. N. RAKHADE*; 

M. JACKSON; E. FITZGERALD; P. KLEIN; C. ZHOU; R. 

HUGANIR; F. E. JENSEN. Children’s Hosp, Harvard Med. Sc, 

Children’s Hosp. and Harvard Med. Sch., Johns Hopkins Univ. 

Sch. of Med. 

8:00 L5 350.13 Cholecystokinin is increased in 

hippocampal dendritic layers of a mouse model of temporal 

lobe epilepsy and redistributed to dendritic spines. M. S. 

WYETH*; N. ZHANG; C. R. HOUSER. David Geffen Sch. of 

Med. at UCLA, VA Greater Los Angeles Healthcare Syst. 

9:00 L6 350.14 Visualizing changes in “silent synapses” 

in the rat hippocampus following neonatal seizures. J. J. 

LIPPMAN BELL*; C. ZHOU; P. M. KLEIN; F. E. JENSEN. 

Children’s Hosp. Boston/Harvard Med. Sch. 

10:00 L7 350.15 PLPP/CIN induces astroglial apoptosis via 

ADF/cofilin system in the rat brain following status epilepticus. 

J. KIM*; H. RYU; S. YEO; O. KWON; B. CHOI; S. CHOI; T. 

KANG. Dept. of Anat. and Neurobiology, Col. of Medicine, 

Hallym Univ., Dept. of Biochemistry, Col. of Natural Science, 

Kyungpook Natl. Univ., Dept. of Physiology, Col. of Medicine, 

Hallym Univ., Dept. of Biomed. Sci. and Res. Inst. for Biosci. 

and Biotechnology, Col. of Life Science, Hallym Univ. 

11:00 L8 350.16 Vascular endothelial growth factor 

receptor overexpression inhibits epileptogenesis in mice. 

L. NIKITIDOU; I. KANTER-SCHLIFKE; J. DHONDT; D. 

LAMBRECHTS; M. KOKAIA*. Wallenberg Neurosci Ctr., 

Vesalius Res. Ctr. 

8:00 L9 350.17 Dual plasticity mechanisms for mGluRmediated 

epileptiform discharges. W. ZHAO*; R. WONG. 

SUNY Downstate Med. Cntr. 

9:00 L10 350.18 Neocortical reorganization after 

experimental febrile seizure in rats: Postnatal experience 

intersects genetic seizure susceptibility. A. Y. REID*; Q. J. 

PITTMAN; G. C. TESKEY. Univ. Calgary. 

10:00 L11 350.19 Aberrant excitatory synapses on layer 

V pyramidal cells following injury. D. K. TAKAHASHI*; I. 

PARADA; D. A. PRINCE. Stanford Univ. 

11:00 L12 350.20 Early changes in magnetic resonance 

imaging parameters distinguish a subset of rats experiencing 

long experimental febrile seizures. M. CHOY; C. M. DUBE*; K. 

AMBADIPUDI; S. SUN; S. BARNES; S. KIM; A. OBENAUS; T. 

Z. BARAM. Univ. of California, Irvine, Loma Linda Univ. 

8:00 M1 350.21 Mechanisms and biomarkers of 

epileptogenesis provoked by prolonged experimental febrile 

seizures. C. M. DUBÉ; T. RAVIZZA; M. HAMAMURA; Q. 

ZHA; A. KEEBAUGH; A. L. ANDRES; O. NALCIOGLU; A. 

OBENAUS; C. E. RIBAK*; A. VEZZANI; T. Z. BARAM. UC 

Irvine, Mario Negri Inst. for Pharmacol. Res., Loma Linda 

Univ. 

9:00 M2 350.22 in vivo detection of mossy fiber sprouting 

using manganese-enhanced magnetic resonance imaging 

(MEMRI) in pilocarpine chronically epileptic rats. J. M. 

MALHEIROS*; R. S. POLLI; L. E. A. M. MELLO; A. TANNÚS; 

L. COVOLAN. Univ. Federal De Sao Paulo, Physics Institute, 

Univ. of São Paulo. 

10:00 M3 350.23 P38 MAPK signaling in mGluR-mediated 

epileptogenesis. S. CHUANG*; R. K. S. WONG. SUNY 

Downstate Med. Cntr. 

11:00 M4 350.24 Damaged CA1 pyramidal neurons 

survive, but display altered dendritic morphology and reexpress 

nestin after kainic acid-induced status epilepticus in 

juvenile rats. F. R. LOPEZ PICON*; T. KUKKO-LUKJANOV; 

K. A. MICHELSEN; I. E. HOLOPAINEN. Univ. of Turku, ) 

Turku PET centre - Preclinical Imaging, Inst. de Recherche 

Interdisciplinaire en Biologie Humaine et Moléculaire 

(IRIBHM). 

8:00 M5 350.25 D2-like dopamine receptor binding and 

D2-like-mediated Gi protein activation in an experimental 

model of temporal lobe epilepsy. D. ALCANTARA- 

GONZALEZ*; B. FLORÁN; L. ROCHA. CINVESTAV - IPN. 

9:00 M6 350.26 Loss of hilar GABAergic interneurons 

at 6-months post-injury: Comparison of SE and TBI models 

of acquired temporal lobe epilepsy. N. E. HUUSKO*; C. 

RÖMER; A. PITKÄNEN. Univ. of Eastern Finland. 



10:00 M7 350.27 • Status epilepticus produces long-term 

enhancement of vesicular release and functional abnormal 

presynaptic mossy fiber terminals in hippocampus. C. 

UPRETI*; P. K. STANTON; E. GARRIDO-SANABRIA. New 

York Med. Coll, Univ. of Texas. 

11:00 M8 350.28 Spatial pattern and severity of cortical 

trauma determine the propensity of post-traumatic 

epileptogenesis. V. VOLMAN*; M. BAZHENOV; T. J. 

SEJNOWSKI. Salk Inst. For Biol. Studies, Univ. of California 

at San Diego, Univ. of California at Riverside. 

8:00 M9 350.29 A Kv7 channel phenotype in the 

chronically epileptic entorhinal cortex. A. MASLAROVA*; A. 

ANDRIOLI; A. WAHAB; C. DERST; R. VEH; U. HEINEMANN. 

Charité Berlin, Univ. of Verona. 

POSTER 

351. Ischemia: Neurovascular Unit 



8:00 M10 351.1 Endothelin-1 (et1) mediates neurovascular 

dysfunction through rho kinase (rock). G. FARACO*; C. 

CAPONE; J. ANRATHER; C. IADECOLA. Weill Med. Col. of 

Cornell Univ. - Div. of Neurobio. 

9:00 M11 351.2 Z-DEVD-fmk protects ZO-1 and 

Cl-5 tight-junction integrity in acute cerebral ischemia. 

C. M. ZEHENDNER*; L. LIBRIZZI; M. DE CURTIS; C. 

R. W. KUHLMANN; H. J. LUHMANN. Inst. of Physiol. 

and Pathophysiology, Unit of Exptl. Neurophysiol. and 

Epileptology. 

10:00 M12 351.3 Sphingosine kinase 2 regulation of hypoxic 

preconditioning-induced ischemic protection: Role of blood 

brain barrier protection. B. WACKER*; A. B. FREIE; J. M. 

GIDDAY. Washington Univ. Sch. of Med. 

11:00 M13 351.4 The effect of agmatine on vascular 

dementia model induced by bilateral common carotid artery 

occlusion in rat. B. HUH; H. JUNG; W. LEE; J. LEE; K. H. 

PARK*. Yonsei University, Col. of Med., BK21 Project for Med. 

Science, Anatomy, Yonsei Univ., Col. of Med. 

8:00 M14 351.5 Blood-brain barrier damage after embolic 

stroke in rats: A novel quantification method and histochemical 

typing of affected tissue. W. HARTIG*; J. GROSCHE; J. 

PELZ; D. SCHNEIDER; C. WEISE; U. BAUER; J. KACZA; U. 

GARTNER; C. HOBOHM; D. MICHALSKI. Univ. Leipzig, PFI, 

Dept. Neurol., Vet. Med., Dept. Anat., Histol. & Embryol. 

9:00 M15 351.6 Enhanced arteriogenesis induced by 

Danshensu treatment after focal cerebral ischemia in mice. D. 

CHEN; W. B. FAULKNER; L. WEI; S. YU*. Emory Univ. 

10:00 M16 351.7 Increased vascular density in the frontal 

cortex of an experimental model of chronic hydrocephalus. A. 

DESHPANDE*; S. DOMBROWSKI; N. KRAJCIR; J. YANG; D. 

SCHMIDT; S. EL-KHOURY; M. LUCIANO. Cleveland Clin. 

11:00 M17 351.8 Polymorphism of peri-infarct 

depolarizations (PID) observed by laser speckle flowmetry in 

relation to brain potassium in permanent focal brain ischemia 

in the rat. A. N. KHARLAMOV*; V. E. YUSHMANOV; S. C. 

JONES. ASRI Allegheny Gen Hosp. 

8:00 M18 351.9 • Thrombin promotes severe vascular 

disruption and tissue injury during cerebral ischemia. B. 

CHEN; Q. CHENG; K. YANG; P. LYDEN*. UCSD, UCSD Sch. 

of Med., Cedars-Sinai Med. Ctr. 



9:00 N1 351.10 • Semaphorin 3A is increased in the 

ischemic cortex after experimental stroke in mice and 

signals through metabolites of 12/15-lipoxygenase to impact 

axon extension and angiogenesis in vitro. A. PEKCEC*; K. 

YIGITKANLI; S. PALLAST; A. ANTIPENKO; D. B. NIKOLOV; 

E. H. LO; K. VAN LEYEN. Massachusetts Gen. Hosp. - 

Harvard Med. Sch., Sloan-Kettering Inst. 

10:00 N2 351.11 Sphenopalatine ganglion: Role in cerebral 

hemodynamics. K. A. SEDEEK*; C. LINE; M. BARNES; A. 

ABDEL MONEM; M. EL SHARIF; J. PROZESKY. Penn State 

Univ., Univ. of Cairo. 

11:00 N3 351.12 Collateral flow after distal middle cerebral 

artery branch occlusion in the mouse. R. A. DEFAZIO*; V. 

OHANNA; S. LEVY; C. L. MORALES; B. D. WATSON; M. A. 

PEREZ-PINZON; R. V. LEVY. Univ. of Miami. 

8:00 N4 351.13 Sildenafil enhances improvement of longterm 

neurological outcome, angiogenesis and neurogenesis 

after focal cerebral ischemia. R. ZHANG*; M. CHOPP; Y. CUI; 

C. ROBERTS; M. WEI; X. WANG; Z. ZHANG. Henry Ford 

Hosp. 

9:00 N5 351.14 Mast cells regulate perivascular 

matrix metalloproteinase activity in experimental ischemic 

stroke. P. J. LINDSBERG*; O. S. MATTILA; J. SAKSI; T. 

PIKKARAINEN; V. RANTANEN; D. STRBIAN. Helsinki Univ. 

Central Hosp, Univ. of Helsinki, Helsinki Univ. Central Hosp. 

10:00 N6 351.15 Nicotine proinflammatory action on brain 

endothelial cells depend on the nAchR/RhoA/NFκBp65 axis. 

S. T. J. BRADFORD; S. M. STAMATOVIC; N. SLADOJEVIC; 

R. F. KEEP; A. ANDJELKOVIC*. Univ. of Michigan. 

11:00 N7 351.16 Protein S protects blood-brain barrier 

integrity through Tyro3 receptor and sphingosine 1-phosphate 

receptor. D. ZHU*; Y. WANG; I. SINGH; R. BELL; R. DEANE; 

Z. ZHONG; A. SAGARE; E. WINKLER; B. ZLOKOVIC. Univ. 

of Rochester. 

8:00 N8 351.17 Effects of long-term administration of 

HMG-CoA inhibitor, Atorvastatin, on microvessels in the 

brain of stroke-prone spontaneously hypertension rats. K. 

NOMURA; M. UEDA*; Y. KATAYAMA. Nippon Med. Sch. 

9:00 N9 351.18 Increase of the arginase expression and 

activity in the neuro-vascular unit over the time in a mice 

model of periphery atherosclerosis disease. J. BADAUT*; K. 

SCHALLER; R. F. DA SILVA. Loma Linda Univ., Geneva Univ. 

Med. Ctr., Swiss Federal Inst. of Technol. Lausanne. 

10:00 N10 351.19 Paradoxical ATP elevation in ischemic 

penumbra revealed by a novel imaging mass spectrometry 

method. M. KAJIMURA; A. KUBO*; K. HATTORI; T. HISHIKI; 

T. NAKANISHI; Y. NAGAHATA; M. SUEMATSU. Keio Univ. 

Sch. of Med., ERATO, JST, Shimadzu Corp. 

POSTER 

352. Ischemia: Oxidative Stress 



8:00 N11 352.1 Identification of tyrosine nitration in 

uchl1 and gapdh relevant to second hand smoking. F. H. 

KOBEISSY*; J. GUINGAB-CAGMAT; Z. ZHANG; K. K. K. 

WANG. Univ. Florida, Banyan Biomarkers. 

9:00 N12 352.2 Expression of aquaporin 4 in oxidative 

stress and its role in astrocyte viability. C. BI; H. MOUKHLES*. 



Mon. AM

10:00 N13 352.3 A free radical scavenger combined with 

mild hypothermia ameliorates ischemic brain damage by 

suppressing matrix metalloproteinase 9. C. NITO*; M. UEDA; 

T. INABA; K. NOMURA; Y. KATAYAMA. Nippon Med. Sch. 

11:00 N14 352.4 Calcium mediated inhibition of reactive 

oxygen species elimination in brain mitochondria. L. 

TRETTER*; E. B. ANGELI; M. R. ARDESTANI; G. GORACCI; 

V. ADAM-VIZI. Semmelweis University, Dept. of Med. 

Biochem., Hungarian Acad. of Sci., Semmelweis Univ., Univ. 

of Perugia. 

8:00 N15 352.5 Multifaceted role of Gpx-1 in a cerebral 

ischemic-reperfusion transgenic mouse model: Deletion 

of Gpx-1 enhanced the physiological basal oxidative state 

resulting in increased susceptibility to neuronal injury in a prooxidant 

environment. M. J. CHEN; C. H. WONG; Z. F. PENG; 

J. MANIKANDAN; A. J. MELENDEZ; P. J. CRACK; S. S. 

CHEUNG*. Menzies Res. Inst., The Univ. of Melbourne, China 

Univ. of Geosciences, Yong Loo Lin Sch. of Medicine, Natl. 

Univ. of Singapore. 

9:00 N16 352.6 Oxidative stress increases the 

complement component 3 after transient focal cerebral 

ischemia in mice. J. YANG; H. AHN; J. YANG; Y. SONG*. 

Sookmyung Women’s Univ. 

10:00 N17 352.7 Protective effects of allyl isothiocyanate 

on choroid plexus damages induced by oxidative stress. J. 

XIANG*; G. ALESI; R. KEEP. Univ. Michigan. 

11:00 N18 352.8 Apotransferrin protects cortical neurons 

from hemoglobin toxicity. J. CHEN-ROETLING; R. F. 

REGAN*. Thomas Jefferson Univ. 

8:00 O1 352.9 Use of a novel reporter to investigate a 

role for hydrogen peroxide in regulating hypoxia-inducible 

factor (HIF). R. E. SPEER*; N. SMIRNOVA; M. BASSO; S. 

KARUPPAGOUNDER; R. HASKEW-LAYTON; H. ALEYASIN; 

I. GAZARAYAN; R. R. RATAN. Burke-Cornell Med. Res. Inst. 

9:00 O2 352.10 Maternal perinatal infection modeled in 

rats by lipopolysaccharide (LPS) administration results in 

localized brain increase in oxidative stress, suppression of 

type 2 deiodinase activity and impaired neurodevelopment 

and learning. E. M. SAJDEL-SULKOWSKA*; Z. L. 

SULKOWSKI; A. M. ZAVACKI; T. CHEN; S. MIDHA; D. G. 

HERRERA; M. XU; N. KOIBUCHI. Harvard Med. Sch/BWH, 

Harvard Univ. Med. Sch., Harvard Med. School/BWH, Gunma 

Univ. Grad. Sch. of Med. 

10:00 O3 352.11 Increased expression of TRPM7 

channel induced neuronal cell death. H. OH*; S. CHUNG. 

SungKyunKwan Univ. 

11:00 O4 352.12 The effects of normobaric hyperoxia 

treatment on the contralateral hemisphere compared to the 

ischemic region of the brain during middle cerebral artery 

occlusion. J. M. WEAVER*, JR; C. LIU; J. HENDREN; K. J. 

LIU. Univ. of New Mexico Col. of Pharm. 

8:00 O5 352.13 Changes of mitochondrial functions as 

a consequence of Ca2+ overload. “Stunned” mitochondria, 

a condition between calcium induced hyperfunction and 

permeability transition pore opening. V. ADAM-VIZI*; K. 

TÖRÖK; A. NAGY; L. TRETTER. Semmelweis Univ., 

Hungarian Acad. of Sci. 

9:00 O6 352.14 Prevention of hypoglycemia-induced 

neuron death by lactate administration. S. SUH*; S. WON; B. 

YOO; M. LEE; Y. YANG; B. CHOI; J. KIM; B. JANG. VAMC, 

UCSF, Sch. of Medicine, Hallym Univ., Inje Paik Hospital, Sch. 

of Medicine, Inje Univ. 

POSTER 

353. Ischemia: Models II 



8:00 O7 353.1 24h-delayed, intramuscular injection of 

an adeno-associated viral vector encoding neurotrophin-3 

promotes sensorimotor forelimb recovery in young adult and 

aged rats following stroke. D. A. DURICKI*; T. H. HUTSON; 

S. SOLEMAN; D. GONZALEZ-CARTER; J. C. PETRUSKA; 

D. CASH; Q. CHEN; H. D. SHINE; F. H. GAGE; L. D. F. 

MOON. King’s Col. London, Imperial Col. London, Dept 

Neurol Surgery, Univ. of Louisville, Neuroimaging Res. Group, 

Inst. of Psychiatry, King’s Col. London, Ctr. for Cell and Gene 

Therapy, Baylor Col. of Medicine,, Dept. of Neurosurgery, 

Baylor Col. of Med., Lab. of Genetics, The Salk Inst. for Biol. 

Studies. 

9:00 O8 353.2 Reversible MCAO in mice as a potential 

model for “ahpasia-like” deficits: Understanding the human 

stroke phenotype. D. T. TRUONG*; V. R. VENNA; C. A. HILL; 

C. E. CLEARY; M. L. ALEXANDER; L. D. MCCULLOUGH; R. 

H. FITCH. Univ. of Connecticut, Univ. of Connecticut Hlth. Ctr. 

10:00 O9 353.3 Sex-specific responses in cell death and 

estrogen receptor expression in cortical explants following 

2-deoxyglucose and potassium cyanide treatment. A. 

TROUT*; J. WESTBERRY; T. SENGOKU; M. WILSON. Univ. 

Kentucky. 

11:00 O10 353.4 � Effects of age at injury on neuropathology 

following neonatal hypoxic-ischemic damage in rodents. E. P. 

KILPATRICK; M. M. MCCLURE; G. D. ROSEN; R. FITCH*. 

Univ. of Connecticut, Beth Israel Deaconnes Med. Center, 

Harvard Med. Sch. 

8:00 O11 353.5 Object and spatial recognition in the 

ischemic gerbil: Importance of occlusion and retention 

interval. B. W. CLEMENT; C. ROBINSON; J. OLD ELK; N. S. 

WILLIAMS; M. BABCOCK*. Montana State Univ. 

9:00 O12 353.6 Nifedipine attenuates spatial working 

memory impairment and white matter damages in mice with 

chronic cerebral hypoperfusion. K. WASHIDA*; M. IHARA; 

Y. HATTORI; Y. OKAMOTO; H. ITO; H. TOMIMOTO; R. 

TAKAHASHI. Kyoto Univ., Mie Univ. 

10:00 O13 353.7 Expression of the extracellular matrix 

molecule, SC1/hevin, after a hemorrhagic stroke. S. LIVELY*; 

L. C. SCHLICHTER. Toronto Western Res. Institutue. 

11:00 O14 353.8 Phenylephrine-induced hypertension 

prevents the loss and/or remapping of functional areas in 

peri-infarct cortex. R. MOSTANY*; C. PORTERA-CAILLIAU. 

UCLA. 

8:00 O15 353.9 In vivo imaging of leukocyte plugging in 

brain capillaries in mouse models of polycythemia vera. T. P. 

SANTISAKULTARM*; N. NISHIMURA; W. L. OLBRICHT; A. 

I. SCHAFER; R. T. SILVER; C. B. SCHAFFER. Cornell Univ., 

Weill Cornell Med. Col. 

9:00 O16 353.10 High frequency cortical activity associated 

with post-ischemic epileptiform discharges in a rat focal stroke 

model in vivo. L. SREJIC*; W. D. HUTCHISON; M. M. AARTS. 

Univ. of Toronto. 

10:00 O17 353.11 Chronic imaging of dendrite dynamics 

after microvascular hemorrhage of a single penetrating 

arteriole in vivo. N. L. ROSIDI*; J. ZHOU; N. NISHIMURA; C. 

SCHAFFER. Cornell Univ., Weill Med. Col. 



11:00 O18 353.12 Neuropathological and anatomical effects 

of Embelin treatment and neonatal HI. C. A. HILL*; M. L. 

ALEXANDER; G. D. ROSEN; R. H. FITCH. Univ. Connecticut, 

Beth Israel Deaconess Med. Ctr. 

8:00 P1 353.13 Effect of chronic resveratrol treatment on 

ischemia-induced cognitive impairments. C. GIRBOVAN*; H. 

PLAMONDON. Univ. of Ottawa. 

9:00 P2 353.14 Regulation of homer 1a and 1c mRNA 

expression in control and ischemia-reperfusion rat brain 

regions. H. CHAI; Y. JIANG; J. SHEN; X. ZHANG; S. FANG; J. 

YANG; J. TU*. Zhongnan Hospital, Wuhan Univ., Sch. of Med. 

10:00 P3 353.15 Delta protein kinase c modulates 

presynaptic targets of cortical microvessels in vivo. H. LIN*; R. 

DEFAZIO; J. W. THOMPSON; K. C. MORRIS; M. A. PEREZ- 

PINZON. Univ. of Miami, Miller Sch. of Med. 

11:00 P4 353.16 Thinning, movement, and volume loss of 

residual cortical tissue occurs after stroke in the adult rat as 

identified by histological and MRI analysis. J. M. KARL*; M. 

ALAVERDASHVILI; A. R. CROSS; I. Q. WHISHAW. Univ. of 

Lethbridge. 

8:00 P5 353.17 Repeated use of the impaired forelimb 

after a unilateral ischemic infarct in motor cortex of the rat 

reduces movement representations in the intact contralateral 

motor cortex. S. BARBAY*; D. J. GUGGENMOS; M. NISHIBE; 

E. J. PLAUTZ; R. J. NUDO. Univ. Kansas Med. Ctr. 

9:00 P6 353.18 • Use of an acute brain slice model of 

ischemia to study the direct application of neurotherapeutics. 

J. A. DETERT*; J. D. HEISLER; T. M. VAN LANGENDON; J. 

R. MOYER, Jr. Univ. of Wisconsin-Milwaukee. 

10:00 P7 353.19 Cilostazol suppressed recombinant tissue 

plasminogen activator-induced brain edema and intracerebral 

hemorrhage in a mice model of MCA occlusion/reperfusion. Y. 

HASE*; M. IHARA; Y. FUJITA; H. ITO; R. TAKAHASHI. Kyoto 

University, Japan. 

11:00 P8 353.20 Parenchymal or metabolic signals are 

unlikely to drive the changes in neocortical microvessel 

diameter after a microvascular occlusion. N. NISHIMURA*; J. 

NGUYEN; N. L. ROSIDI; C. B. SCHAFFER; C. IADECOLA. 

Cornell Univ., Weill Med. Col. of Cornell Univ. 

8:00 P9 353.21 Protein transduction domain-mediated 

drug delivery targeting ischemic penumbra by use of a fusion 

protein with oxygen-dependent degradation domain of HIF-1. 

Y. FUJITA*; T. KUCHIMARU; T. KADONOSONO; M. IHARA; 

R. TAKAHASHI; M. HIRAOKA; S. KIZAKA-KONDOH. Kyoto 

Univ., Tokyo Inst. of Technol. 

9:00 P10 353.22 Evaluation of the therapeutic benefit 

with delayed administration of erythropoietin following 

an early hypoxic ischemic injury in rodent models. M. L. 

ALEXANDER*; C. A. HILL; T. ROSENKRANTZ; R. H. FITCH. 

Univ. Connecticut, Univ. of Connecticut Hlth. Ctr. 

10:00 P11 353.23 Spectrally resolved recordings of the 

intrinsic optical signal during hypoxia-induced spreading 

depression. M. MUELLER*; M. MANÉ. Univ. Goettingen. 

11:00 P12 353.24 Correlation between regional brain volume 

reduction and diffusion tractography in infants with perinatal 

hypoxic-ischemic brain injury. M. CHOE*; E. TAKAHASHI; D. 

SLIVA; K. KRISHNAMOORTHY; A. BENASICH; C. NELSON; 

E. GRANT. Children’s Hosp. Boston, Harvard Med. Sch., 

Martinos Ctr. for Biomed. Imaging, Massachusette Gen. 

Hospital, Harvard Med. Sch., Massachusetts Gen. Hospital, 

Harvard Med. Sch., Ctr. for Mol. & Behavioral Neuroscience, 

Rutgers Univ. 



8:00 P13 353.25 • Stimulus-evoked calcium transients 

in somatosensory cortex are inhibited after a nearby 

microhemorrhage. F. A. MEDINA*; N. NISHIMURA; C. B. 

SCHAFFER. Cornell Univ. 

POSTER 

354. Traumatic Brain Injury: Mechanisms I 



8:00 P14 354.1 Impact of thalamocortical circuit injury 

on calcium dynamics in identified neurons and glia. M. K. 

JAISWAL*; N. P. CRAMER; F. W. LISCHKA; X. XU; R. 

VERMA; Z. GALDZICKI. Uniformed Services Univ. of the Hlth. 

Sci., Ctr. for Neurosci. and Regenerative Med. 

9:00 Q1 354.2 Neural codes are altered by stretch injury 

to in vitro networks. A. M. CHOO*; A. HOCKENBERRY; C. R. 

VON REYN; D. F. MEANEY. Univ. Pennsylvania. 

10:00 Q2 354.3 • Differential sulfation of chondroitin in 

the glial scar following controlled cortical impact injury. 

J. YI*; Y. KATAGIRI; D. FIGGE; P. YU; B. SUSARLA; A. 

SYMES; H. M. GELLER. NIH, Ctr. for neuroscience and 

regenerative medicine, uniformed services university of the 

health sciences, Uniformed services university of the health 

sciences. 

11:00 Q3 354.4 Outcomes of mild traumatic brain injury 

in a rodent model. J. PEREZ-POLO*; H. C. REA; M. A. 

PARSLEY; M. M. WHITE; G. G. C. UNABIA; K. M. JOHNSON; 

R. J. GRILL; D. S. DE WITT; C. E. HULSEBOSCH. Univ. 

Texas Med. Br, UTMB, UTHSC Houston. 

8:00 Q4 354.5 Immunohistochemical investigation of glial 

regeneration following cerebellar injury in rat. I. ADORJAN*; K. 

BINDICS; P. GALGOCZY; M. KALMAN. Semmelweis Univ. 

9:00 Q5 354.6 Sustained deficits in compound action 

potential following non-contusive brain trauma in the immature 

rat is associated with decreases in the phosphorylation state 

of axonal neurofilaments. A. DILEONARDI*; J. W. HUH; R. 

RAGHUPATHI. Drexel Univ. Coll. of Med., Children’s Hosp. of 

Philadelphia. 

10:00 Q6 354.7 Intraspinal rewiring of the corticospinal 

tract compensates lost function after brain injury. M. UENO*; 

T. YAMASHITA. Osaka Univ. 

11:00 Q7 354.8 Neo-epitope antibody production to 

monitor calpain activity. S. GHOSHAL; R. P. GUTTMANN*. 

Univ. Kentucky. 

8:00 Q8 354.9 � Early inflammatory response to mild 

traumatic brain injury. P. LEE; P. CHIANG; D. J. FINK*; M. 

MATA. Univ. of Michigan. 

9:00 Q9 354.10 • Familial hemiplegic migraine-associated 

Cav2.1 Ca2+channel mutations worsen secondary brain 

damage after traumatic brain injury. N. A. TERPOLILLI*; A. 

M. J. M. VAN DEN MAAGDENBERG; B. B. TODOROV; K. 

WAEHNER; M. D. FERRARI; N. PLESNILA. Univ. of Munich, 

Dept. of Neurosurg., Walter Brendel Zentrum for Exptl. Med., 

Leiden Univ. Med. Ctr., Univ. of Mannheim, Royal Col. of 

Surgeons in Ireland. 

10:00 Q10 354.11 Traumatic brain injury in Ccr2deficient 

mice results in reduced inflammatory response. 

C. ISRAELSSON*; A. KYLBERG; H. BENGTSSON; L. 

HILLERED; T. EBENDAL. Dept. Neuroscience, Uppsala Univ. 


Mon. AM

11:00 Q11 354.12 Anatomical and functional alterations in 

ventricular ependymal cells after traumatic brain injury. G. 

XIONG*; J. ELKIND; S. KUNDU; E. TAMASHIRO; J. COLE; 

N. A. COHEN; A. S. COHEN. Children’s Hosp Philadelphia, 

Univ. of Pennsylvania, Univ. of Philadelphia. 

8:00 Q12 354.13 Traumatic brain injury increase in CB1 

receptor expression is dependent of the photoperiod. 

J. J. MORALES*; M. MARTINEZ-VARGAS; A. PEREZ- 

ARREDONDO; L. NAVARRO; F. ESTRADA-ROJO. 

FACULTAD DE MEDICINA UNAM. 

9:00 Q13 354.14 Temporal cytokine expression patterns 

in the rat hippocampus following a traumatic brain injury. 

L. A. SHAPIRO*; K. KATKI; G. M. ARISI; A. RUCH; M. L. 

FORESTI. Texas A&M Univ. COM, Scott & White Hosp., 

Central Texas Veterans Hlth. Care Syst. 

10:00 Q14 354.15 The phosphorylation dependence of 

HspB1 and its interaction with actin. J. W. CLARKE*; F. 

NAFAR; K. MEAROW. Mem. Univ. of Newfoundland. 

11:00 Q15 354.16 In situ localization of MicroRNAs 

after traumatic brain injury and the effect of therapeutic 

hypothermia. J. S. TRUETTNER*; O. F. ALONSO; H. M. 

BRAMLETT; W. D. DIETRICH. Univ. Miami Miller Sch. of Med. 

8:00 Q16 354.17 Traumatic brain injury down-regulates 

A-type potassium channels in hippocampal neurons. Z. LEI*; 

P. DENG; Z. C. XU. Indiana Univ. Sch. of Med. 

9:00 Q17 354.18 Adenosine A2A receptor deficiency 

attenuates cognitive dysfunction induced by blast injury in 

mice. Y. ZHOU*; Y. NING; N. YANG; S. DAI; X. CHEN; Y. 

ZHAO; P. LI; J. CHEN. Res. Inst. Surg and Daping Hosp. 

,TMMU, Boston Uni. Sch. Med. 

10:00 Q18 354.19 Branched chain amino acids reset 

inhibitory synaptic activity after traumatic brain injury. B. N. 

JOHNSON*; G. XIONG; S. KUNDU; J. ELKIND; C. MITALA; 

A. COHEN. Children’s Hosp. of Philadelphia, Univ. of 

Pennsylvania. 

11:00 R1 354.20 Persistent neuronal activation of the 

transcription factor c-Jun following related diffuse axonal 

injury. J. E. GREER*; M. J. MCGINN; J. T. POVLISHOCK. 

Virginia Commonwealth Universi. 

8:00 R2 354.21 Effect of chronic stress on the outcome 

of traumatic brain injury. A. B. GYORGY*; E. KOVESDI; S. 

KWON; D. WINGO; J. WALKER; D. V. AGOSTON. Anatomy, 

Physiol. and Genetics, Uniformed Services Univ. 

9:00 R3 354.22 Proapoptotic transcription factors and 

traumatic brain injury. J. N. CHANG*; V. RUBOVITCH; M. J. 

KANE; C. L. BUTLER; J. S. DENNIS; V. DELIC; H. HATIC; C. 

G. PICK; B. A. CITRON. Bay Pines VA Healthcare Syst., Univ. 

of South Florida Col. of Med., Sackler Sch. of Med. 

10:00 R4 354.23 Traumatic axonal injury in the optic 

nerve and its relation to axonal dieback, amyloid precursor 

protein immunoreactive change and local blood-brain barrier 

disruption. J. WANG*; S. A. WALKER; R. T. HAMM; J. T. 

POVLISHOCK. Virginia Commonwealth Univ. 

11:00 R5 354.24 • Proteomic identification of plasma 

biomarkers and pathogenic mechanisms in APOE3 and 

APOE4 mouse models of TBI. B. C. MOUZON*; A. BISHOP; 

G. KAYIHAN; B. KATZ; J. REED; S. FERGUSON; V. 

MATHURA; A. ROSES; M. MULLAN; F. CRAWFORD. The 

Roskamp Inst., James A. Haley Veterans’ Hosp., Executive 

Training Center, Duke Univ. 

8:00 R6 354.25 Heterogeneity of NG2 glia revealed by 

electrophysiology and imaging. K. LEMEUR*; H. STEFFENS; 

A. SCHELLER; K. KARRAM; J. TROTTER; F. KIRCHHOFF. 

Max Planck Inst. of Exptl. Med., Saarland Univ., Johannes 

Gutenberg Univ. Mainz. 

9:00 R7 354.26 Genetic in vitro and in vivo evidence 

for a role of Cdc42 in astrocyte polarity, wound closure 

and astrocyte proliferation. S. ROBEL*; S. BARDEHLE; A. 

LEPIER; C. BRAKEBUSCH; M. GÖTZ. Ludwig Maximilians 

Univ. and Helmholtz Zentrum München, Univ. of Copenhagen. 

10:00 R8 354.27 Chordin- and netrin-induced lineage 

plasticity of SVZ progenitors after demyelination. B. 

JABLONSKA*; A. AGUIRRE; M. RAYMOND; G. SZABO; Y. 

KITABATAKE; K. SALIOR; G. MING; H. SONG; V. GALLO. 

Children’s Natl. Med. Ctr., SUNY at Stony Brook Univ., 

Children’s Hosp., Inst. of Exptl. Med., Osaka Univ. Sch. of 

Med., Johns Hopkins Univ. Sch. of Med. 

11:00 R9 354.28 Are spreading ischemia and thrombin 

two factors influencing lesion development following acute 

subdural hematoma? B. ALESSANDRI*; S. TRETZEL; T. 

KRÄMER; A. HEIMANN; O. KEMPSKI. Univ. Med. of the 

Johannes Gutenberg-University Mainz. 

8:00 R10 354.29 � Traumatic brain injury leads to 

decreased expression of synaptic pro-survival signaling 

components in membrane lipid rafts. J. A. BONDS*; Y. HU; I. 

R. NEISMAN; H. H. PATEL; S. KRAJEWSKI; P. M. PATEL; B. 

P. HEAD. Univ. of California At San Diego, Sanford-Burnham 

Med. Res. Inst. 

9:00 R11 354.30 Chondroitin sulfate-4,6 glycosaminoglycan 

significantly inhibits rat embryonic day 18 (E18) cortical 

neurons in vitro and choindroitin 4,6 sulfotransferase mRNA 

is over-expressed after CNS injury. L. KARUMBAIAH*; S. 

ANAND; R. THAZHATH; Y. ZHONG; R. V. BELLAMKONDA. 

Georgia Tech/Emory Univ., Georgia Inst. of Technology/Emory 

Univ., Roche Diagnostics, Peking Univ. 

POSTER 

355. Traumatic Brain Injury: Mechanisms II 



8:00 R12 355.1 Omega-3-fatty acid deficiency during 

pregnancy and brain development elevates the risk for 

anxiety-like disorders after adult brain trauma. H. S. BHATIA*; 

S. SHARMA; F. GOMEZ-PINILLA. Univ. of California Los 

Angeles. 

9:00 R13 355.2 Microglial activation induced by traumatic 

brain injury is supressed by delayed administration of a PARP 

inhibitor. J. C. D’AVILA*; T. I. LAM; D. WANG; S. J. WON; 

N. HONBO; T. M. KAUPPINEN; R. A. SWANSON. Veterans 

Affairs Med. Ctr., Univ. of California. 

10:00 R14 355.3 Injury-induced cell proliferation in brain 

repair and recovery of function. K. M. DRUMHELLER*; D. W. 

LEE. California State Univ., California State University, Long 

Beach. 

11:00 R15 355.4 The autophagy-lysosome pathway is 

altered in an in vitro model of traumatic brain injury. B. J. 

MADER*; A. M. LUKER; S. L. STONE; N. NGUYEN; J. J. 

SHACKA. UAB. 

8:00 R16 355.5 Exploring retinal astrocytes in health and 

injury: A method for studying astrocyte plasticity. G. LUNA*; 

P. W. KEELEY; J. BYUN; B. E. REESE; G. P. LEWIS; S. K. 

FISHER. Univ. of California, Santa Barbara, Mayachitra Inc. 



9:00 R17 355.6 • IG20-SV4 induces caspase-8 expression 

and activation in neuroblastoma cells via regulating promoter 

activity. L. LI*; B. S. PRABHAKAR; M. N. MERIGGIOLI. UIC, 

Univ. of Illinois at Chicago, Col. of Med. 

10:00 R18 355.7 Mapping the window of reduced 

glutamatergic activation after developmental brain injury 

using pharmacological MRI (phMRI). N. SANTA MARIA; N. G. 

HARRIS; D. A. HOVDA; C. C. GIZA*. UCLA. 

11:00 S1 355.8 Alterations in aquaporin expression 

after traumatic brain injury. C. M. ATKINS*; Y. KANG; C. 

FURONES; A. OLIVA. Univ. of Miami Miller Sch. of Med. 

8:00 S2 355.9 Genetic mapping of reactive gliosis after 

traumatic brain injury. Y. ZHENG*; Y. FENG; J. WANG; X. QI; 

D. H. KIM; Q. CAO. Univ. of Texas Hlth. Sci. Ctr. At Houston, 

the Third Hosp. of Hebei Med. Univ. 

9:00 S3 355.10 Sleep deprivation prior to controlled 

cortical impact impairs motor/sensory and cognitive functions. 

S. G. SOEHNLEN*; K. J. BRYAN; S. L. BALL; R. G. 

RIECHERS, II. Cleveland State Univ., Louis Stokes Cleveland 

DVA Med. Ctr., Cleveland Clin., Case Western Reserve Univ. 

10:00 S4 355.11 Time course of nitric oxide synthase 

expression in cortex and hippocampus in a controlled cortical 

impact mouse model of traumatic brain injury. D. M. MILLER*; 

J. WANG; K. M. CARRICO; E. D. HALL. Univ. of Kentucky. 

11:00 S5 355.12 Protection with Bcl-2 20-34 against early 

and late phase long term potentiation impairment induced by 

trauma in CA1 hippocampal neurons. K. L. PANIZZON*; R. A. 

WALLIS. Sepulveda VAMC 111N-1, VA Greater Los Angeles 

Healthcare Syst. 

8:00 S6 355.13 Subarachnoid hemorrhage causes 

arteriolar spasms and thrombosis in the cerebral 

microcirculation. B. FRIEDRICH*; F. MUELLER; K. 

SCHOELLER; N. PLESNILA. Walter-Brendel-Zentrum, Royal 

Col. of Surgeons in Ireland, Univ. hospital of Munich. 

9:00 S7 355.14 Repeated exposure to low level blast 

overpressure produces impairment in acquisition of spatial 

information in a Morris water maze. S. T. AHLERS*; 

M. SHAUGHNESS; D. A. SHEAR; M. CHAVKO; R. M. 

MCCARRON; J. R. STONE. Naval Med. Resch Ctr., Walter 

Reed Army Inst. of Res., Univ. of Virginia Sch. of Med. 

POSTER 

356. Traumatic Brain Injury: Therapeutic Approaches I 



8:00 S8 356.1 � Environmental enrichment impacts 

novelty preference in rats with a generalized audiogenic 

seizure history. T. C. FRANCIS*; A. M. MORGAN; B. R. 

MINTON; J. L. MILTON; L. B. SPENCE; J. L. ROSS; M. C. 

ZRULL. Appalachian State Univ. 

9:00 S9 356.2 The adverse effect on spatial learning 

following chronic administration of haloperidol or risperidone 

after experimental brain trauma is long-lasting. R. H. 

AHMED; K. E. SHAW; R. L. MCALOON; Y. T. OLUGBADE; 

S. A. GHUMAN; K. M. EHRENBERG; I. H. CHOWDHURY; 

J. P. CHENG; A. N. HOFFMAN; R. D. ZAFONTE; T. D. 

HERNANDEZ*; A. E. KLINE. Univ. of Pittsburgh, Arizona 

State Univ., Spaulding Rehabil. Hospital, Harvard, Univ. of 

Colorado at Boulder. 



10:00 S10 356.3 A rehabilitation-relevant paradigm for 

neurobehavioral recovery after experimental traumatic brain 

injury. A. H. PANOS; B. W. DE WITT; R. L. MCALOON; K. M. 

EHRENBERG; K. E. SHAW; B. M. GANTI; J. P. CHENG*; A. 

E. KLINE. Univ. Pittsburgh, Univ. of Pittsburgh. 

11:00 S11 356.4 Environmental enrichment affects aspects 

of audiogenic seizures in developmentally primed rats. M. C. 

ZRULL*; A. E. MURRAY; D. A. BATIANSILA; J. L. MILTON; T. 

C. FRANCIS; L. B. SPENCE. Appalachian State Univ. 

8:00 S12 356.5 � A combined therapeutic regimen of 

buspirone and enrichment is more efficacious than either 

alone in enhancing cognition in pediatric rats after TBI. R. 

L. MCALOON; S. M. CHLEBOWSKI; K. M. GEBHARDT; 

M. MAJOR; K. E. SHAW; J. P. CHENG; J. HENCHIR; L. W. 

JENKINS; A. E. KLINE*. Univ. Pittsburgh. 

9:00 T1 356.6 Cognitive training and functional recovery 

in middle-aged animals following traumatic brain injury. A. 

SWAN*; M. R. HOANE. Southern Illinois Univ. Carbondale. 

10:00 T2 356.7 Biological effects of pre-injury exercise 

administration in mice receiving TBI. V. POP*; J. S. COATS; 

D. SORENSEN; R. E. HARTMAN; T. GARLAND, Jr; A. 

OBENAUS; J. BADAUT. Loma Linda Univ., Univ. of California, 

Riverside. 

11:00 T3 356.8 • The effects of a grape-enriched diet 

and traumatic brain injury on behavior and neuropathology 

in a transgenic mouse model of Alzheimer’s disease. R. 

E. HARTMAN*; M. DULCICH; B. SILBER; J. COATS; A. 

OBENAUS. Loma Linda Univ. 

8:00 T4 356.9 • MRI and DTI markers for TBI-related brain 

tissue damage and plasticity in a rat CCI model demonstrate 

protective effects of 2DG. E. B. HUTCHINSON*; K. 

DETTMAN; P. RUTECKI; E. MEYERAND; T. SUTULA. Univ. 

of Wisconsin - Madison. 

9:00 T5 356.10 • Lingo-1 inhibition following traumatic 

brain injury in rats. A. HÅNELL*; F. CLAUSEN; A. 

WALMSLEY; L. HILLERED; N. MARKLUND. Uppsala Univ., 

Novartis AG. 

10:00 T6 356.11 Evaluation of acute post-injury 

administration of docosahexaenoic acid in experimental 

traumatic brain injured rats. H. Q. YAN; X. MA; Y. LI; S. 

CULVER; C. DIXON*. Univ. of Pittsburgh. 

11:00 T7 356.12 Improved outcome in a mouse model 

of TBI following administration of a novel therapeutic 

compound. S. FERGUSON*; B. MOUZON; J. PHILLIPS; V. 

GANAPAPTHI; A. BISHOP; G. KAYIHAN; V. MATHURA; M. 

MULLAN; F. CRAWFORD. Roskamp Inst., James A Haley 

Veterans Admin. 

8:00 T8 356.13 Metallothionein promotes regenerative 

axonal growth and growth cone turning by interacting with 

LRP receptors. A. K. WEST*; L. M. LANDOWSKI; Y. K. 

LEUNG; L. FOA; R. S. CHUNG. Univ. of Tasmania, Menzies 

Res. Inst. 

9:00 T9 356.14 Effects of transcranial cortical stimulation 

and motor rehabilitative training on functional recovery 

following unilateral cortical infarcts in rats. A. O’BRYANT*; 

H. COMBS; S. NORDQUIST; T. A. JONES. Univ. Texas @ 

Austin. 

10:00 T10 356.15 Controlled manipulation of thyroid 

hormones alters brain endoplasmic reticulum calcium uptake 

and release mechanisms in male Sprague-Dawley rats. 

W. KEAN*; D. ALLEN; D. C. MCMULLEN; A. VERMA; J. T. 

COLE; W. D. WATSON. Uniformed Services University/ Henry 

M Jackson Fndn. 


Mon. AM

11:00 T11 356.16 Effects of cortical electrical stimulation 

combined with motor training on anatomical plasticity following 

traumatic brain injury (TBI) in rats. S. C. JEFFERSON*; N. A. 

DONLAN; K. BOUCEK; D. A. KOZLOWSKI; T. A. JONES; D. 

L. ADKINS. Univ. of Texas at Austin, DePaul Univ., Univ. of 

Texas At Austin. 

8:00 T12 356.17 Effects of deferoxamine on collagenaseinduced 

hemorrhagic brain injury in mice. H. WU*; T. WU; S. 

BUSSE; J. WANG; J. WANG. Anesthesiology/Critical Care 

Medicine, Johns Hopkins Univ. 

9:00 T13 356.18 Neuroprotective gene regulation after 

traumatic brain injury. B. A. CITRON*; C. L. BUTLER; M. J. 

KANE; V. RUBOVITCH; J. S. DENNIS; V. DELIC; H. HATIC; 

J. N. CHANG; C. G. PICK. Bay Pines VA Healthcare Syst., 

Univ. of South Florida Col. of Med., Sackler Sch. of Med. 

10:00 T14 356.19 The intricate involvement of survival and 

ER stress signaling pathways following mild traumatic brain 

injury in mice. C. G. PICK*; A. SHACHAR; H. WERNER; V. 

RUOOVITCH. Tel Aviv Univ., Sackler Fac. of Medicine, Tel- 

Aviv Univ. 

11:00 T15 356.20 The therapeutic impact of Exendin-4 on 

cognitive impairments in mice after mTBI. C. G. PICK; L. 

RACHMANY; V. RUBOVITCH; D. TWEEDIE; Y. LI; N. H. 

GREIG*. Tel-Aviv Univ., Intramural Res. Program, Natl. Inst. 

On Aging, NIH. 

8:00 T16 356.21 Effect of enriched environment on the 

outcome of traumatic brain injury. E. KOVESDI*; A. GYORGY; 

S. KWON; D. WINGO; J. WALKER; C. KASPER; D. 

AGOSTON. Uniformed Univ. of the Hlth. Sci. 

9:00 T17 356.22 Suppression of early cerebellar damage 

and oxidative stress after sublethal total body irradiation by 

tetrahydrobiopterin/ S-5,6,7,8-tetrahydro-D-neopterin. L. 

CUI*; D. PIERCE; K. E. LIGHT; Q. FU; M. HAUER-JENSEN. 

Univ. of Arkansas For Med. Sci., Central Arkansas Veterans 


10:00 T18 356.23 Transcranial direct current stimulation 

targeting the spared right posterior parietal hemisphere 

improves severe visuospatial neglect. C. DESIMONE; R. J. 

RUSHMORE; L. AFIFI; A. VALERO CABRE*. Lab. Cerebral 

Dynamics, Boston Univ. Sch. of Med. 

11:00 U1 356.24 Neutrophil derived matrix 

metalloproteinase-9 is a candidate determinant of an 

emerging cognitive deficit after traumatic injury to the 

developing murine brain. H. M. ADWANIKAR*; T. PFANKUCH; 

J. RABER; L. J. NOBLE-HAEUSSLEIN. Univ. of California, 

San Francisco, Oregon Hlth. & Sci. Univ. 

POSTER 

357. Spinal Cord Injury: Cellular and Molecular Mechanisms: 

Glia 



8:00 U2 357.1 ER stress reaction of oligodendrocyte 

precursor cell and astrocyte after traumatic spinal cord injury 

in rat. D. MATSUYAMA*; M. WATANABE; K. SUYAMA; J. 

MOCHIDA. Tokai Univ. 

9:00 U3 357.2 Spatial and temporal changes in promoter 

activity of the astrocyte glutamate transporter, GLT1, 

following traumatic spinal cord injury. N. J. MARAGAKIS*; 

J. O’DONNELL; J. F. BONNER; C. PAUL; M. E. MILLER; B. 

RAUCK; R. A. KUSHNER; J. D. ROTHSTEIN; I. FISCHER; A. 

C. LEPORE. Johns Hopkins Univ., Drexel Univ. Col. of Med. 

10:00 U4 357.3 Reduction in levels of the astrocyte 

glutamate transporter, GLT1, worsens functional and 

pathohistological outcomes following traumatic spinal cord 

injury. A. C. LEPORE*; J. O’DONNELL; C. P. O’BANION; N. J. 

MARAGAKIS. Johns Hopkins Sch. Med. 

11:00 U5 357.4 Spinal cord contusion injury stimulates 

endogenous SOX2 expressing cells in adult mice. H. J. LEE*; 

J. R. WRATHALL. Georgetown Univ. Med. Ctr. 

8:00 U6 357.5 GGF2 and FGF2, growth factors 

that stimulate endogenous precursor cell proliferation, 

improve functional recovery after spinal cord injury. M. T. 

WHITTAKER*; H. J. LEE; A. PAJOOHESH-GANJI; J. WU; A. 

SHARP; R. J. WYSE; J. R. WRATHALL. Georgetown Univ. 

Med. Ctr. 

9:00 U7 357.6 Spinal cord contusion alters chondroitin 

sulfate proteoglycan expression distal to the site of injury in 

rats. E. M. ANDREWS*; R. J. RICHARDS; Q. F. YIN; M. S. 

VIAPIANO; L. B. JAKEMAN. Ohio State Univ. 

10:00 U8 357.7 The effects of severe spinal cord contusion 

injury on regional glial reactivity and CSPG expression in 

distant segments of the spinal cord. R. J. RICHARDS*; E. 

M. ANDREWS; F. YIN; M. VIAPIANO; L. B. JAKEMAN. Ohio 

State Univ. Col. of Med. 

11:00 U9 357.8 Understanding the role of transcription 

factor PPAR-delta in oligogenesis after spinal cord injury. A. A. 

ALMAD*; D. M. MCTIGUE. Ohio State Univ. 

8:00 U10 357.9 Histone Deacetylase responses to 

contusive spinal cord injury and ER Stress in mouse 

oligodendrocyte precursor cells. T. A. DINCMAN*; J. E. 

BEARE; S. S. OHRI; N. J. KUYPERS; V. GALLO; S. R. 

WHITTEMORE. Univ. Louisville, Children’s Natl. Med. Ctr. 

9:00 U11 357.10 Attenuating the ER stress response 

improves functional recovery after spinal cord injury. S. S. 

OHRI*; M. MADDIE; Y. ZHAO; M. QIU; M. HETMAN; S. R. 

WHITTEMORE. Univ. Louisville. 

10:00 U12 357.11 Mechanical trauma initiates astrocyte 

border formation via STAT3 signaling. I. B. WANNER*; A. B. 

FERNANDEZ; Z. GRAY-THOMPSON; A. LI; B. SONG; M. V. 

SOFRONIEW. UCLA. 

11:00 U13 357.12 Potential of C-Met agonists to attenuate 

deposition of the glial scar. T. T. LOGAN*; P. YU; H. M. 

GELLER; O. MUNGUNSUKH; R. M. DAY; A. J. SYMES. 

Uniformed Services Univ. of Hlth. Sci., Natl. Heart, Lung and 

Blood Institute, NIH. 

8:00 U14 357.13 A specific role for Smad3 in mediating the 

actions of TGF-β in glial scar formation. B. T. SUSARLA*; E. 

D. LAING; P. YU; Y. KATAGIRI; H. M. GELLER; A. J. SYMES. 

Uniformed Services Univ., Natl. Heart, Lung and Blood 

Institute, Natl. Inst. of Hlth. 

9:00 U15 357.14 In vitro model for the study of adult spinal 

cord reactive astrocytes. S. CODELUPPI*; E. NORSTED- 

GREGORY; C. G. WIGERBLAD; J. KJELL; L. OLSON; C. I. 

SVENSSON. Karolinska Institutet. 

10:00 U16 357.15 Characterization of the glial scar using 

raman spectroscopy and microindentation. T. SAXENA*; 

B. DENG; J. GILBERT; J. CHAIKEN; D. STELZNER; J. 

HASENWINKEL. Syracuse Univ., SUNY Upstate Med. Univ. 

11:00 U17 357.16 The multifaceted role of p53 following 

spinal cord trauma. E. M. FLORIDDIA*; A. TEDESCHI; A. 

WUTTKE; G. QUADRATO; S. DI GIOVANNI. Hertie Inst. for 

Clin. and Brain Research, Univ. of Tuebingen, Grad. Sch. in 

Cell. and Mol. Neuroscience. Univ. of Tuebingen and Max- 

Plank Inst., Children`s Hosp. 



POSTER 

358. Spinal Cord Injury: Cellular and Molecular Mechanisms: 

Regeneration 



8:00 U18 358.1 Survival and regeneration of adult 

motoneurones by grafted neuroectodermal stem cells 

following avulsion injury: Insights into the molecular 

mechanism. K. PAJER*; G. FEICHTINGER; D. KLEIN; H. 

REDL; A. NÓGRÁDI. Lab. of Neuromorphology, Dept. of 

Ophthalmology, Univ. of Szeged, Ludwig Boltzmann Inst. for 

Clin. and Exptl. Traumatology, VetOMICS, Univ. of Vet. Med. 

9:00 V1 358.2 A multi-step screening approach 

successfully uncovers novel target genes involved in the 

regeneration-promoting properties of olfactory ensheathing 

glia cells. K. C. ROET*; E. H. P. FRANSSEN; A. H. W. 

ESSING; N. FAGOE; S. J. ZIJLSTRA; F. M. DE BREE; R. E. 

VAN KESTEREN; A. B. SMIT; J. VERHAAGEN. Netherlands 

Inst. For Neurosci., Univ. of Cambridge, VU Univ. 

10:00 V2 358.3 Use of biomatrices to improve axon 

regeneration after chronic spinal cord injury in the rat. V. 

ESTRADA*; N. BRAZDA; H. W. MUELLER. Mol. Neurobio. 

Laboratory, Heinrich Heine Univ. 

11:00 V3 358.4 Primary neuronal brainstem culture from 

adult zebrafish: Interactions with an inhibitory chondroitin 

sulfate proteoglycan-rich environment. A. TAPANES- 

CASTILLO; F. SHABAZZ; K. VAJN; M. OUDEGA; J. A. 

PLUNKETT*. St Thomas Univ., Univ. of Pittsburgh. 

8:00 V4 358.5 Neurocan mRNA expression following 

CNS injury in adult zebrafish (Danio rerio). J. A. PLUNKETT; 

A. TAPANES-CASTILLO*; F. SHABAZZ; K. VAJN; M. 

OUDEGA. St. Thomas Univ., Univ. of Pittsburgh. 

9:00 V5 358.6 Molecular and cellular development of 

scar tissue in the injured spinal cord of adult zebrafish (Danio 

rerio). K. VAJN*; A. TAPANES-CASTILLO; F. SHABAZZ; J. 

A. PLUNKETT; M. OUDEGA. Univ. of Pittsburgh, St. Thomas 

Univ. 

10:00 V6 358.7 Molecular basis of neural reconnection in 

the transected spinal cord of the freshwater turtle Trachemys 

dorbignyi. G. GARCÍA; G. LIBISCH; O. TRUJILLO; R. E. 

RUSSO*; C. ROBELLO. Inst. de Investigaciones Biológicas 

Clemente Estable, Inst. Pasteur, IIBCE. 

11:00 V7 358.8 Multiple intrinsic and extrinsic factors 

restrict sensory axon regeneration in chronic spinal cord injury. 

K. KADOYA*; M. TUSZYNSKI. UCSD, VA Med. Ctr. 

8:00 V8 358.9 Bladder recovery and nerve regeneration 

in complete spinal cord transected rats treated with a 

peripheral nerve graft, acidic fibroblast growth factor, and 

Chondroitinase ABC. Y. LEE*; C. LIN; V. LIN; J. SILVER. 

Cleveland Clin., Case Western Reserve Univ. 

9:00 V9 358.10 Adenovirus-mediated gene transfer of 

prostacyclin synthase in olfactory ensheathing cells promotes 

functional recovery after transplantation into transected rat 

spinal cords. M. TSAI*; S. SHYUE; Y. HUANG; C. HUANG; D. 

LIOU; H. CHENG. Neurolog Inst, Taipei Veterans Gen. Hosp., 

Inst. of Biomed. Sciences, Academia Sinica, Dept. of Vet. 

Medicine, Natl. Chung-Hsing Univ., Inst. of Pharmacology, 

Sch. of Medicine, Natl. Yang-Ming Univ. 

10:00 V10 358.11 The effect of complement proteins on 

neuronal outgrowth and regeneration. S. L. PETERSON; H. X. 

NGUYEN; O. MENDEZ; A. J. ANDERSON*. Univ. Calif, Irvine. 



11:00 V11 358.12 • CST axons that regenerate as a result of 

PTEN deletion form synapses caudal to a spinal cord lesion. 

R. WILLENBERG*; I. SEARS-KRAXBERGER; K. LIU; A. 

TEDESCHI; Z. HE; O. STEWARD. Univ. of California at Irvine 

Sch. of Med., Harvard Med. Sch. 

8:00 V12 358.13 Bioengineered scaffolds facilitate axonal 

guidance and regeneration after spinal cord injury. M. GAO; 

T. GROS; J. SAKAMOTO; C. CHAN; S. MEHROTRA; 

D. LYNAM; P. LU; J. H. BROCK*; A. BLESCH; M. H. 

TUSZYNSKI. UCSD, Michigan State Univ., VA Med. Ctr. 

9:00 V13 358.14 HSV-mediated gene transfer C3 

transferase to inhibit Rho promotes CNS axonal regeneration. 

M. MATA; Z. ZHOU*; X. PENG; P. CHIANG; J. KIM; D. J. 

FINK. Univ. Michigan. 

10:00 V14 358.15 • Fibroblast growth factor 1 loaded 

biodegradable device allows spinal cord regeneration 

and cortically induced neuromuscular response of the leg 

after resection of the spinal cord. P. M. MATTSSON*; J. 

NORDBLOM; S. THAMS; J. PERSSON; J. ÅBERG; H. 

ENQVIST; J. SJÖDAHL; L. BRUNDIN; B. MEIJER; M. A. 

SVENSSON. Karolinsk Hosp, Columbia Univ., Uppsala Univ., 

Bioarctic AB. 

11:00 V15 358.16 A novel 3d scaffold for neuronal 

regeneration in spinal cord injury: From development to in 

vitro and in vivo characterization. N. SILVA*; R. A. SOUSA; 

J. T. OLIVEIRA; J. S. FRAGA; R. CERQUEIRA; H. LEITE- 

ALMEIDA; J. F. MANO; A. ALMEIDA; N. SOUSA; R. L. REIS; 

A. J. SALGADO. Life and Hlth. Sci. Res. Inst. (ICVS), Sch. 

of Hlth. Sci., 3B’s Res. Group - Biomaterials, Biodegradables 

and Biomimetics, Univ. of Minho, Headquarters of the 

European Inst. of Excellence on Tissue Engin. and 

Regenerative Med., Inst. for Biotech. and Bioengeneering, PT 

Government Associated Lab. 

8:00 V16 358.17 Role of axonal degeneration in 

locomotor recovery after spinal cord injury. E. COLLYER*; 

V. VALENZUELA; F. A. COURT. Pontificia Univ. Católica De 

Chile. 

9:00 V17 358.18 Calcium signalling induced by the neurite 

growth inhibitor nogo-a. A. SCHMANDKE*; A. SCHMANDKE; 

M. E. SCHWAB. Brain Res. Inst. - Neuromorphology. 

POSTER 

359. Neuroinflammation: Cellular and Molecular Mechanisms II 



8:00 V18 359.1 Status epilepticus -induced brain injury 

increases chemokine expression, microglial activation and 

macrophage appearance in rat. E. A. JOHNSON*; T. L. DAO; 

R. K. KAN. US Army Med. Res. Inst. of Chem. Def. 

9:00 W1 359.2 Na+/H+ exchange-mediated H+ 

homeostasis is a key event for microglial activation. D. 

KINTNER; V. CHANANA; J. ALGHARABLI; B. GUNDLACH; 

P. FERRAZZANO*; J. OLSON; D. SUN. Univ. Wisconsin, 

Waisman Ctr. 

10:00 W2 359.3 RSAD2 regulates the expression of 

proinflammatory cytokines, but not nitric oxide in activated 

miroglia. E. CHUNG*; H. BAE. Kyung Hee University, Col. of 

Oriental Med. 

11:00 W3 359.4 Differential inflammatory gene regulation 

by hypoxia in murine microglia. J. J. WATTERS*; S. CRADER. 

Univ. Wisconsin. 


Mon. AM

8:00 W4 359.5 Effects of in vitro administration of proinflammatory 

cytokines on pc12 cells. K. A. MCLINDEN*; G. 

W. BOEHM; M. J. CHUMLEY; G. AKKARAJU. Texas Christian 

Univ. 

9:00 W5 359.6 PGD 2 induces cell death in neuron 

enriched culture independent of activation of DP1 or DP2 

receptors. W. LI*; M. AHMAD; H. LIU; S. H. GRAHAM. VA 

Pittsburgh Healthcare Syst., Univ. of Pittsburgh. 

10:00 W6 359.7 Social stress disrupts virus-specific 

adaptive immunity during acute Theiler’s virus infection. E. E. 

YOUNG*; E. G. VICHAYA; J. L. COOK; N. M. REUSSER; C. 

WELSH; M. W. MEAGHER. Texas A&M Univ. 

11:00 W7 359.8 Curcumin alleviates inflamation-induced 

cognitive and motor impairments in mice. E. M. KAWAMOTO*; 

M. MUGHAL; C. SCAVONE; M. M. MATTSON; S. 

CAMANDOLA. NATIONAL INSTITUTE ON AGING/ 

NATIONAL INSTITUTES OF HEALTH, Univ. of Sao Paolo. 

8:00 W8 359.9 Subarachnoid hemorrhage (SAH)associated 

microvascular dysfunction and neuropathology: 

Possible link to the S100B/ RAGE (receptor for advanced 

glycation end-products) pathway. C. PAISANSATHAN; L. 

MAO; F. VETRI; H. XU*; D. PELLIGRINO. Univ. Illinois 

Chicago. 

9:00 W9 359.10 Cooperative contributions of IRF1 and 

IRF2 to interferon-gamma-mediated cytotoxic effects on 

oligodendroglial progenitor cells. M. HORIUCHI*; A. ITOH; 

D. PLEASURE; K. OZATO; T. ITOH. Univ. California Davis, 

Inst. for Pediatric Regenerative Medicine, Shriners Hosp. 

for Children Northern California, Natl. Inst. of Child Hlth. and 

Human Development, Natl. Inst. of Hlth. 

10:00 W10 359.11 Palmitoylethanolamide blunts beta 

amyloid-induced reactive astrogliosis. C. SCUDERI; G. 

ESPOSITO; A. BLASIO; M. VALENZA; L. STEARDO, jr; 

V. SABINO*; D. DE FILIPPIS; T. IUVONE; V. DI MARZO; 

L. STEARDO. Sapienza Univ. of Rome, Univ. of Chieti and 

Pescara “G. d’Annunzio”, Second Univ. of Naples, Boston 

Univ. Sch. of Med., Univ. of Naples Federico II, CNR. 

11:00 W11 359.12 Acute phase protein effects in the cerebral 

microvasculature. K. S. MARK*; J. ROBERTS; S. ZHANG. 

Texas Tech. Univ. Hlth. Sci. Ctr. 

8:00 W12 359.13 Dual inmunomodulatory role of basic 

fibroblast growth factor in astrocytes. M. LICHTENSTEIN*; 

J. L. MADRIGAL; E. GALEA. Inst. of Neurosciences, 

Univ. Autònoma Barcelona, Facultad de Medicina, Univ. 

Complutense de Madrid. 

9:00 W13 359.14 Serotonergic modulation of 

proinflammatory cytokines and indoleamine 2,3 dioxygenase 

expression in cultured rat cortical astrocytes. Z. WANG*; S. 

REGUNATHAN; M. AUSTIN. Univ. of Mississippi Med. Ctr. 

10:00 W14 359.15 Naloxone and IL-1ra restore mu-opioidevoked 

Ca2+ signaling in inflammatory reactive astrocytes. 

E. L. HANSSON*; A. WESTERLUND; U. BJÖRKLUND. 

Sahlgrenska Acad. Univ. of Gothenburg, Neurosci. and 

Physiol. 

11:00 X1 359.16 Role of Akt and microRNA-155 in the 

innate immune response of human microglia and astrocytes. 

L. TARASSISHIN; H. SUH; C. F. BROSNAN; O. LOUDIG; S. 

C. LEE*. Albert Einstein Col. Med. 

POSTER 

360. Cell Death Mechanisms: DNA Damage and Repair 



8:00 X2 360.1 Enhancement of DNA damage 

neurotoxicity by pharmacological inhibition of histone 

deacetylases. A. VASHISHTA*; M. HETMAN. Univ. Louisville, 

Univ. of Louisville. 

9:00 X3 360.2 Homeodomain-interacting protein kinase 

2 (HIPK2) regulates cAMP-response element binding protein 

(CREB) dependent transcription through phosphorylation on 

serine 271 in response to genotoxic stress. K. SAKAMOTO*; 

B. HUANG; K. IWASAKI; K. HAILEMARIAM; J. NINOMIYA- 

TSUJI; Y. TSUJI. The Ohio State Univ., North Carolina State 

Univ., Nagoya Univ. Sch. of Med. 

10:00 X4 360.3 Role of histone deacetylase inhibitors 

in neuroprotection against DNA damage-induced death. C. 

BROCHIER*; M. RIVIECCIO; K. MCLAUGHLING; R. R. 

RATAN; B. C. LANGLEY. Burke Med. Res. Inst. of Cornell 

Univ., Weill Med. Col. of Cornell Univ. 

11:00 X5 360.4 Significant alterations in expression of 

diverse genes in hippocampus following a brief postnatal 

lead exposure. L. J. WALINCHUS*; D. W. ANDERSON; W. A. 

METTIL; S. K. KIDD; J. S. SCHNEIDER. Thomas Jefferson 

Univ. 

8:00 X6 360.5 Methylation status of genes related to 

nervous system development and function as well as other 

key biological pathways is significantly affected by low level 

childhood lead exposure. J. S. SCHNEIDER*; J. CHEN; 

C. SZETO; D. W. ANDERSON; B. P. LANPHEAR; S. HO. 

Thomas Jefferson Univ., Univ. Cincinatti Med. Ctr., BC 

Children’s Hosp. & Simon Fraser Univ. 

9:00 X7 360.6 Effects of lead exposure on DNA 

methylation and MeCP2 regulation in rats. D. W. 

ANDERSON*; J. S. SCHNEIDER. Thomas Jefferson Univ. 

10:00 X8 360.7 Epigenetic mechanisms underlying central 

nervous system toxicity of heavy metals. R. VERMA; X. XU; 

G. CARETTI; Z. GALDZICKI*. Dept. of Anatomy, Physiol. 

and Genetics, SOM, USUHS, Dept. of Biomolecular Sci. and 

Biotechnology, Univ. of Milan. 

11:00 X9 360.8 Influences of gender, environment, and 

dose of developmental lead exposure on gene expression 

profiles in the hippocampus. W. METTIL*; D. W. ANDERSON; 

L. WALINCHUS; R. SCHRAY; S. KIDD; J. S. SCHNEIDER. 

Thomas Jefferson Univ. 

8:00 X10 360.9 Interactions of gender and environment 

on behavioral outcome from different levels and durations 

of developmental lead exposure. K. POTHAKOS*; D. W. 

ANDERSON; R. SCHRAY; L. WALINCHUS; E. DECAMP; J. 

S. SCHNEIDER. Thomas Jefferson Univ. 

9:00 X11 360.10 • Histone deacetylase inhibitors inhibit 

survival of dopaminergic neuronal cells against toxin-induced 

cytotoxicity. C. PAGE*; S. ROSE; P. JENNER. King’s Col. 

London. 

10:00 X12 360.11 Hdac3 promotes neurodegeneration and 

might represent a target of neuroprotective hdac inhibitors. F. 

H. BARDAI*; S. R. D’MELLO. Univ. of Texas at Dallas. 

11:00 X13 360.12 Comet analysis of methamphetamine, 

ecstasy and nicotine induced neurotoxicity damage in pc-12 

cells. L. E. LYN-COOK*, JR; W. DING; B. WORD; S. LANTZ; 

S. ALI. NCTR. 



8:00 X14 360.13 Endothelial cells modulates apoptosis of 

neural progenitors after genotoxic stress. C. WONG*; F. LU; Y. 

LI; I. AUBERT. Sunnybrook Hlth. Sci. Ctr. 

POSTER 

361. Neurotoxicity and neurodegeneration III 



8:00 X15 361.1 Tolerance to the protective effects against 

DFP-induced neuronal damage in rat brain is produced by 

long-term treatment with diazepam but not with imidazenil. B. 

KADRIU; A. GUIDOTTI; J. GOCEL; J. M. DAVIS; J. AUTA*. 

Univ. Illinois at Chic. 

9:00 X16 361.2 Progranulin inhibits NF-κB activation in 

microglia and protects against Aβ-mediated neuronal toxicity. 

S. MINAMI*; S. MIN; L. HERL; B. SUN; Y. ZHOU; P. ZHOU; 

R. V. FARESE, Jr.; L. GAN. Gladstone Inst. of Neurolog. 

Dis., Univ. of California, San Francisco, Gladstone Inst. of 

Cardiovasc. Dis. 

10:00 X17 361.3 Differential effects of the inflammogen, 

lipopolysaccaride, upon animals with a partial deletion of the 

gdnf receptor, gfrα1, gene. H. A. BOGER*; C. UMPHLET; A. 

GRANHOLM. Med. Univ. of South Carolina. 

11:00 X18 361.4 � Poly (ADP-ribose) polymerase inhibition 

in the rat brain by chronic arsenic exposure is associated 

with deficits on behavioral performance. F. D. CEBALLOS*; 

O. GALICIA-CRUZ; J. M. DELGADO; L. MARTINEZ; M. E. 

JIMÉNEZ. Univ. Autónoma de San Luis Potosi. 

8:00 Y1 361.5 Methamphetamine-induced striatal 

cytogenesis requires dopamine-1 receptor function. I. K. 

TULLOCH*; J. A. ANGULO. CUNY-Hunter Col. 

9:00 Y2 361.6 D2 dopamine receptors are involved 

in neurotoxicity induced by mdma and methamphetamine 

in mice. N. GRANADO; S. ARES-SANTOS; I. RUIZ; I. 

ESPADAS; E. O´SHEA; J. R. NARANJO; M. I. COLADO; 

R. MORATALLA*. Cajal Institute, CSIC, Univ. Complutense 

Madrid, CIBERNED, CNB, CSIC. 

10:00 Y3 361.7 Attenuation of methamphetamine-induced 

striatal nitric oxide formation by somatostatin in mice. L. 

AFANADOR*; J. A. ANGULO. CUNY Hunter Col. 

11:00 Y4 361.8 Modulation of the methamphetamineinduced 

production of nitric oxide in the striatum by 

neuropeptide y and cellular targets of nitric oxide. H. 

YAROSH*; J. A. ANGULO. Hunter Col. 

8:00 Y5 361.9 Polybrominated diphenyl ethers interact 

with neurotrophic actions of triiodothyronine and vasopressin 

V1a receptors in primary cortical cultures. M. C. CURRAS- 

COLLAZO*; S. OH; T. MOORE; T. MURPHY; A. LULLA; R. 

ORNELAS; H. ALM; A. WANG; D. DEMISSIE; R. CALMA. UC 

Riverside, Uppsala University, Div. of Toxicology, DeLaSalle 

Univ. 

9:00 Y6 361.10 Modeling symptoms of chemotherapy: 

Bortezomib induces sickness in mice. E. G. VICHAYA*; J. 

COOK; E. YOUNG; M. MEAGHER. Texas A&M Univ. 

10:00 Y7 361.11 Effects of choline supplementation on 

cholinergic system development in rats exposed to alcohol 

during the brain growth spurt. B. R. MONK*; J. D. THOMAS. 

San Diego State Univ. 



11:00 Y8 361.12 The effects of arsenic exposure on 

glucose transporters and insulin receptor in hippocampus 

of C57BL/6J male mice. M. CRUZ GARCIA; J. LIMÓN 

PACHECO; L. DEL RAZO JIMÉNEZ; M. GIORDANO*; V. 

RODRÍGUEZ CÓRDOVA. Inst. de Neurobiología, Dept. 

de Toxicología, CINVESTAV, Univ. Nacional Autónoma De 

México. 

8:00 Y9 361.13 Determination of retrograde transport of 

nanomaterials from airways to neurons. C. J. PINGEL*; M. 

SRIVATSAN. Arkansas State Univ. 

9:00 Y10 361.14 The effect of 2,4-dichlorophenoxyacetic 

acid (2,4-D) on development and anxiety-like behaviors 

in rats. W. HAMLET; M. DOPHEIDE; R. E. MORGAN*; 

J. DEFORD; S. L. MCFADDEN. Western Illinois Univ., 

Monmouth Col. 

10:00 Y11 361.15 � Metals impair short and long-term 

potentiation. A. CHOWDHURY*; S. SADIQ; Z. GHAZALA; D. 

BÜSSELBERG. Weill Cornell Med. Col. In Qatar. 

11:00 Y12 361.16 Pre-synaptic targets of metal 

interactions. S. SADIQ*; Z. GHAZALA; A. CHOWDHURY; D. 

BÜSSELBERG. Weill Cornell Med. Col. In Qatar. 

8:00 Y13 361.17 Interaction of metals with postsynaptic 

targets. Z. GHAZALA*; A. CHOWDHURY; S. SADIQ; D. 

BÜSSELBERG. Weill Cornell Med. College-Qatar. 

9:00 Y14 361.18 Effects of testosterone and progesterone 

upon methamphetamine-induced neurotoxicity in male mice. 

A. B. BULETKO; W. GELDENHUYS; J. L. MCDERMOTT*; D. 

DLUZEN. Northeastern Ohio Univ. Col. Med. 

10:00 Y15 361.19 Morphological and biochemical changes 

in pheripheral nerve of young rats after subchronic exposed 

to heavy metals. M. MENDEZ-ARMENTA*; C. NAVA-RUIZ; 

F. FERNÁNDEZ-VALVERDE; A. SANCHEZ-GARCIA; M. 

ALCARAZ-ZUBELDIA; R. MONDRAGÓN; J. MANJARREZ; 

A. DIAZ-RUIZ. Natl. Inst. Neurol Neurosurg. 

POSTER 

362. Molecular Mechanisms in Schizophrenia and Autism: 

human Pathology 



8:00 Y16 362.1 Molecular alterations associated with 

the COMT schizophrenia risk gene. A. A. SHUKLA*; T. 

BIRCHFIELD; K. GLEASON; B. POTTS; C. TAMMINGA; S. 

GHOSE. UT Southwestern Med. Center, Dallas. 

9:00 Y17 362.2 Schizophrenia, amphetamine-induced 

sensitized state and acute amphetamine exposure all show 

a common alteration: Increased dopamine d2 receptor 

dimerization. M. WANG*; L. PEI; P. J. FLETCHER; S. KAPUR; 

P. SEEMAN; F. LIU. CAMH affliated Univ. Toronto, Ctr. for 

Addiction and Mental Hlth., Univ. of Toronto, Univ. of London. 

10:00 Y18 362.3 • Development of endocannabinoid markers 

in monkey prefrontal cortex. S. M. EGGAN*; D. W. VOLK; 

S. KAMPRATH; P. RADCHENKOVA; D. A. LEWIS. Univ. 

Pittsburgh. 

11:00 Z1 362.4 Immunoquantification of parvalbumin 

and GAD67 in prefrontal cortex schizophrenia tissue. M. 

YANAGI*; R. H. JOHO; B. W. POTTS; B. J. PRASLICKA; S. 

J. M. ARNOLD; K. L. LEWIS-AMEZCUA; S. GHOSE; C. A. 

TAMMINGA. UT Southwestern Med. Ctr. 


Mon. AM

8:00 Z2 362.5 • Effects of antipsychotic exposure on 

intracortical excitatory, thalamocortical, and inhibitory boutons 

in primate primary auditory cortex. C. E. MOYER*; K. M. 

DELEVICH; K. N. FISH; J. ASAFU-ADJEI; A. J. DEO; D. A. 

LEWIS; R. A. SWEET. Univ. Pittsburgh, VISN 4 Mental Illness 

Research, Educ. and Clin. Ctr. (MIRECC), VA Pittsburgh 


9:00 Z3 362.6 Gene profiling of laser-captured pyramidal 

and parvalbumin-immunoreactive neurons in the superior 

temporal gyrus of schizophrenia subjects. C. Y. PIETERSEN; 

M. P. LIM; X. J. CHEN; R. STEPHENS; R. M. MCCARLEY; 

K. C. SONNTAG*; T. W. WOO. McLean Hosp., ABCC 

SAIC-Frederick, NCI/NIH, Harvard Med. Sch., VA Boston 

Healthcare Syst., Beth Israel Deaconess Med. Ctr. 

10:00 Z4 362.7 • Metabotropic glutamate receptor 4 and 7 

expression in schizophrenia. S. GHOSE*; K. GLEASON; A. 

SHUKLA; B. POTTS; C. TAMMINGA. UTSW Med. Ctr. 

11:00 Z5 362.8 • Lower parvalbumin and GABA membrane 

transporter 1 expression in schizophrenia: Potential 

contributions of reduced GAD67 in parvalbumin cells. A. A. 

CURLEY*; S. M. EGGAN; D. A. LEWIS; M. S. LAZARUS; Z. 

J. HUANG. Univ. Pittsburgh, Univ. of Pittsburgh, Cold Spring 

Harbor Lab., Stony Brook Univ. 

8:00 Z6 362.9 • Changes in cortical mu opioid receptors 

in schizophrenia and across development and aging. D. W. 

VOLK*; D. A. LEWIS. Univ. of Pittsburgh. 

9:00 Z7 362.10 MicroRNA expression profiling of 

pyramidal neurons in layer 3 of the superior temporal gyrus 

in schizophrenia. S. KIM; K. SONNTAG; T. WOO*. McLean 

Hosp., McLean Hosp. and Harvard Med. Sch. 

10:00 Z8 362.11 • GABAA alpha1 subunit mRNA 

expression in pyramidal cells and interneurons in the 

dorsolateral prefrontal cortex of schizophrenia subjects. J. R. 

GLAUSIER*; H. H. BAZMI; M. BENEYTO; D. A. LEWIS. Univ. 

Pittsburgh. 

11:00 Z9 362.12 • Identification of molecular markers for 

parvalbumin- or somatostatin-positive GABA neurons in the 

human dorsolateral prefrontal cortex. D. D. GEORGIEV*; Y. 

MINABE; D. A. LEWIS; T. HASHIMOTO. Kanazawa Univ. 

Grad. Sch. of Med. Sci., Univ. of Pittsburgh. 

8:00 Z10 362.13 Proportional densities of GABA neuron 

subtypes across areas of auditory cortex in schizophrenia. D. 

PERGOLIZZI; A. J. DWORK; B. MANCEVSKI; B. ILIEVSKI; 

E. C. DIAS*; C. BLEIWAS; K. FIGARSKY; D. C. JAVITT; J. 

F. SMILEY. Nathan Kline Inst., New York Psychiatric Inst., 

Columbia Univ., City Col. 

9:00 Z11 362.14 • Developmental trajectories of markers of 

GABA neurotransmission in monkey prefrontal cortex. G. D. 

HOFTMAN*; H. H. BAZMI; D. A. LEWIS. Univ. of Pittsburgh. 

10:00 Z12 362.15 Examining LTP markers in hippocampal 

subfields in schizophrenia. C. A. TAMMINGA*. Univ. Texas 


11:00 Z13 362.16 Alterations in Dopamine D2 receptor 

isoform gene expression in the DLPFC of patients with 

schizophrenia. D. A. ROTHMOND*; M. AKIL; C. S. 

WEICKERT. Prince of Wales Med. Res. Inst., Schizophrenia 

Res. Inst., Univ. of New South Wales, Georgetown Univ. 

Hosp. 

8:00 Z14 362.17 Increased expression of APRIL (TNFSF13) 

in prefrontal grey matter from patients with schizophrenia. V. 

S. CATTS*; C. S. WEICKERT. Prince of Wales Med. Res. 

Inst., Schizophrenia Res. Inst., Univ. of New South Wales. 

9:00 AA1 362.18 Changes in TrkB isoform expression in the 

prefrontal cortex of patients with schizophrenia: identification 

of gender-specific alterations. J. WONG*; D. A. ROTHMOND; 

M. J. WEBSTER; C. WEICKERT. Schizophrenia Res. Inst., 

Prince of Wales Med. Res. Inst., Univ. of New South Wales, 

Stanley Med. Res. Inst. 

10:00 AA2 362.19 The short isoform of the GABA A receptor 

subunit Γ2 and its linkage to greater benzodiazapine binding 

in schizophrenia. S. G. FILLMAN*; M. VERDURAND; K. 

ZAVITSANOU; C. SHANNON WEICKERT. Schizophrenia 

Res. Inst., Prince of Wales Med. Res. Inst., Univ. of 

New South Wales, Australian Nuclear Sci. and Technol. 

Organization. 

11:00 AA3 362.20 Superficial interstitial white matter neuron 

density is increased in the dorsolateral prefrontal cortex 

of people with schizophrenia. S. J. FUNG*; Y. YANG; A. 

ROTHWELL; D. ROTHMOND; S. TIANMEI; C. SHANNON 

WEICKERT. Schizophrenia Res. Inst., Prince of Wales Med. 

Res. Inst., Univ. of New South Wales, Peking Univ. Inst. of 

Mental Hlth. 

8:00 AA4 362.21 Enhanced carbonyl stress in a 

subpopulation of schizophrenia. M. ARAI*; T. ICHIKAWA; M. 

MIYASHITA; A. NISHIDA; I. NOHARA; N. OBATA; M. ARAI; 

T. YOSHIKAWA; Y. OKAZAKI; H. UJIKE; T. MIYATA; M. 

FUKUMOTO; R. HASHIMOTO; T. ARINAMI; I. KUSHIMA; N. 

OZAKI; S. KOIKE; R. TAKIZAWA; K. KASAI; M. ITOKAWA. 

Tokyo Inst. of Psychiatry, Lab. for Mol. Psychiatry, RIKEN 

Brain Sci. Inst., Dept. of Psychiatry, Tokyo Metropolitan 

Matsuzawa Hosp., Dept. of Neuropsychiatry, Okayama Univ. 

Grad. Sch. of Med. and Dent., Ctr. for Translational and 

Advanced Res. on Human Disease, Tohoku Univ. Grad. Sch. 

of Med., Dept. of Psychiatry, Osaka Univ. Grad. Sch. of Med., 

Inst. of Basic Med. Sciences, Univ. of Tsukuba, Nagoya Univ. 

Grad. Sch. of Med., Grad. Sch. of Med. and Fac. of Medicine, 

Univ. of Tokyo. 

9:00 AA5 362.22 Subunit-specific changes in 

N-glycosylation of ionotropic glutamate receptor subunits 

in frontal cortex in schizophrenia. J. TUCHOLSKI*; L. D. 

MCMILLAN; M. S. SIMMONS; V. HAROUTUNIAN; J. H. 

MEADOR-WOODRUFF. Univ. Alabama-Birmingham, Mount 

Sinai Sch. of Med. 

10:00 AA6 362.23 Intracellular signaling deficits in frontal 

cortex of schizophrenia. A. FUNK*; V. HAROUTUNIAN; R. 

MCCULLUMSMITH; J. MEADOR-WOODRUFF. UAB, Mt. 

Sinai. 

11:00 AA7 362.24 Mechanism of parvalbumin transcriptional 

regulation: Relevance to cortical interneuron function and 

schizophrenia pathophysiology. J. M. RUTHERFORD*; 

V. HAROUTUNIAN; J. H. MEADOR-WOODRUFF; R. M. 

COWELL. UAB, Mt. Sinai Sch. of Med. 

8:00 AA8 362.25 Abnormalities of glutamate transmission in 

animal models of schizophrenia. R. E. MCCULLUMSMITH*; 

M. SIMMONS; G. RUMBAUGH; J. TUCHOLSKI; J. MEADOR- 

WOODRUFF. Univ. Alabama-Birmingham, The Scripps Res. 

Inst. 

9:00 AA9 362.26 Using lcm-qpcr to study neuronal 

circuitry of schizophrenia in postmortem human brain 

tissue. M. SIMMONS; S. YATES; G. NELSON; S. DAY; R. 

MCCULLUMSMITH; V. HAROUTUNIAN; J. H. MEADOR- 

WOODRUFF*. Univ. Alabama at Birmingham, Mt. Sinai Sch. 

of Med. 



10:00 AA10 362.27 TARP Γ and cornichon dysregulation in 

the ACC and DLPFC in schizophrenia. J. B. DRUMMOND*; 

J. TUCHOLSKI; M. S. SIMMONS; D. C. DAHL; V. 

HAROUTUNIAN; J. H. MEADOR-WOODRUFF. Univ. 

Alabama, Birmingham, Mount Sinai Sch. of Med. 

11:00 AA11 362.28 Postmortem analysis of cell density 

in autistic temporal cortex. J. CAMACHO; Z. COMBS; C. 

SCHUMMAN; D. AMARAL; V. MARTINEZ-CERDENO*. UC 

Davis, MIND Institute, UC Davis. 

POSTER 

363. Early Developmental Influences in Animal Models of 

Psychiatric Diagnoses 



8:00 AA12 363.1 Differential effect of maternal cytokines 

on acute and sensitized response to amphetamine in the 

adult offspring. A. AGUILAR VALLES*; S. JUNG; E. DAI; C. 

FLORES; G. N. LUHESHI. McGill Univ. 

9:00 AA13 363.2 Modeling Schizophrenia: Glutamate 

carboxypeptidase II mice with folate deficiencies. J. E. 

BERGER-SWEENEY*; J. T. COYLE; L. R. SCHAEVITZ. 

Wellesley Col., McLean Hospital/Harvard Med. Sch. 

10:00 AA14 363.3 � Exposure to high levels of kynurenic acid 

during adolescence leads to cognitive dysfunction during 

adulthood. C. O. AKAGBOSU; G. C. EVANS; D. J. BUCCI*. 

Dartmouth Col. 

11:00 AA15 363.4 Modeling schizophrenia in a mouse model 

of genetic Nogo-A deficiency. R. WILLI*; M. E. SCHWAB. 

Univ. & ETH Zurich. 

8:00 AA16 363.5 Withdrawal from amphetamine as an 

animal model of schizophrenia. D. PELEG-RAIBSTEIN*; 

J. FELDON. Federal Inst. of Technol. Zurich; Behavioural 

Neurobio. Lab. 

9:00 AA17 363.6 Behavioral disturbances in adult mice 

following neonatal influenza infection - possibly induced 

by a transient elevation of brain kynurenic acid levels. 

M. HOLTZE*; L. ASP; H. KARLSSON; G. ENGBERG; S. 

ERHARDT. Dept. Physiol. & Pharmacology, Karolinska 

Institutet. 

10:00 AA18 363.7 The loss of NMDA receptors in 

interneurons as a model of psychosis related neuropathology. 

P. M. CANAS*; R. W. GREENE. UT Southwestern Med. Ctr. 

11:00 BB1 363.8 Attentional set-shifting deficits in a 

neurodevelopmental animal model of schizophrenia - 

Reversal with an alpha7 nAChR agonist. J. M. BROOKS*; 

M. S. THOMSEN; J. D. MIKKELSEN; M. SARTER; J. P. 

BRUNO. Ohio State Univ., Univ. of Copenhagen Hosp., Univ. 

of Michigan. 

8:00 BB2 363.9 • Individual differences in maternal 

response to immune challenge predict NMDA receptormediated 

behavior of offspring. S. L. BRONSON*; R. 

AHLBRAND; P. S. HORN; N. M. RICHTAND. Univ. of 

Cincinnati Col. of Med., Dept. of Veterans Affairs Med. Ctr. 

9:00 BB3 363.10 Early effects of GABA receptor blockade 

in the amygdala on parvalbumin interneurons in the rat 

hippocampus. M. MARKOTA; M. BRESJANAC*. Univ. 

Ljubljana Fac. of Med., Univ. Ljubljana Med. faculty. 



10:00 BB4 363.11 • Glutaminase deficient mouse as a 

model of schizophrenia resilience. S. RAYPORT*; Y. WANG; 

N. CHUHMA; H. ZHANG; O. ARANCIO; E. SIBILLE; I. 

GAISLER-SALOMON. Columbia Univ., NYS Psychiatric Inst., 

Univ. of Pittsburgh, Haifa Univ. 

11:00 BB5 363.12 Cognitive inflexibility in rats with a neonatal 

ventral hippocampal lesion is associated with a disinhibited 

prefrontal cortex. G. G. CALHOON; I. SHUSTERMAN; 

A. J. GRUBER; M. R. ROESCH; G. SCHOENBAUM; P. 

O’DONNELL*. Univ. Maryland Sch. Med., Univ. of Lethbridge, 

Univ. of Maryland Col. Park. 

8:00 BB6 363.13 • Effects of postnatal maternal separation 

in serine racemase knockout mice, a model of early life stress 

interaction with NMDA receptor hypofunction. A. C. BASU*; 

A. S. ROSEMAN; J. T. COYLE. McLean Hosp., Harvard Med. 

Sch. 

9:00 BB7 363.14 Daao and GCPII inhibition for 

schizophrenia. B. S. SLUSHER*; T. TSUKAMOTO; D. 

FERRARIS; Y. TAKATSU; Y. FUJITA; A. SAWA; H. JAARO- 

PELED; C. ROJAS; K. HASHIMOTO. John Hopkins Brain Sci. 

Inst., Johns Hopkins Univ., Chiba Univ. 

10:00 BB8 363.15 Three hit hypothesis of schizophrenia 

validated in rats: enhanced vulnerability after early life and 

adolescent adverse experiences of genetically predisposed 

individuals. N. P. DASKALAKIS*; E. REMMERS; W. L. 

FUNG; W. MEELIS; M. S. OITZL; E. R. DE KLOET. Leiden / 

Amsterdam Ctr. of Drug Res. - Leiden Univ. Med. Ctr. 

11:00 BB9 363.16 Neonatal functional inactivation of the 

prefrontal cortex results in an increased dopaminergic 

response in the core part of the nucleus accumbens to 

D-amphetamine treatment in adult rats. F. MEYER; A. E. 

LOUILOT*. INSERM U666- Fac. of Medicine- UdS. 

8:00 BB10 363.17 Impact of combined maternal immune 

activation and peripubertal THC administration upon 

schizophrenia-related behaviours in rats. G. M. STENSON; J. 

A. PRATT; R. R. BRETT*. Univ. of Strathclyde. 

9:00 BB11 363.18 Critical role of the prefrontal cortex in the 

regulation of hippocampus-accumbens information flow in a 

developmental animal model of schizophrenia. P. BELUJON*; 

M. H. PATTON; A. A. GRACE. Univ. Pittsburgh. 

10:00 BB12 363.19 Imbalance of excitation and inhibition in 

the prefrontal cortex after neonatal ventral hippocampal lesion 

in the rat. R. RYAN; S. K. BHARDWAJ; L. K. SRIVASTAVA*; T. 

P. WONG. McGill Univ., Douglas Mental Hlth. Univ. Inst. 

11:00 BB13 363.20 Redox dysregulation affects parvalbumin 

interneurons and local neuronal synchronization in the 

anterior cingulate cortex of adult mice. P. STEULLET*; J. 

CABUNGCAL; M. CUENOD; K. Q. DO. Ctr. For Psychiatric 

Neurosciences. 

8:00 BB14 363.21 Neonatal exposure to NMDA receptor 

antagonists halts the maturation of parvalbumin-positive 

fast-spiking interneurons, leading to altered network activity 

in adulthood. A. PINTO-DUARTE*; M. BONJEAN; M. M. 

BEHRENS; T. J. SEJNOWSKI. The Salk Inst. For Biol. 

Studies and Howard Hughes Med. Inst. 

9:00 BB15 363.22 Postnatal expression of a dominant 

negative DISC1 transgene under the αCaMKII promoter 

is sufficient to elicit several endophenotypes relevant 

to schizophrenia, which are augmented by a neonatal 

environmental stressor. H. JAARO-PELED*; M. NIWA; A. W. 

JOHNSON; D. IBI; D. R. SMITH; B. HUANG; S. POU; C. A. 

FOSS; M. G. POMPER; T. NABESHIMA; M. GALLAGHER; 

M. V. PLETNIKOV; K. YAMADA; A. SAWA. Johns Hopkins 

Univ., Meijo Univ., Nagoya Univ. 


Mon. AM

10:00 BB16 363.23 Dopaminergic disturbance and behavioral 

deficits in a novel genetic model of DISC1, which are highly 

influenced by social isolation stress. M. NIWA*; H. JAARO- 

PELED; S. TANKOU; B. HUANG; S. POU; N. OZAKI; T. 

HIKIDA; A. KAMIYA; T. NABESHIMA; A. SAWA. Dept. 

Psychiaty and Behavioral Sciences, Johns Hopkins Univ. 

Sch. of Med., Dept. Chem. Pharmacology, Grad. Sch. of 

Pharmaceut. Sci., Meijo Univ., Dept. Psychiatry, Nagoya Univ. 

Grad. Sch. of Med., Dept. Neurosci., Johns Hopkins Univ. 

Sch. of Med. 

11:00 BB17 363.24 Synergistic interactions between prenatal 

immune challenge and peri-pubertal stress in the disruption 

of adult behavioral functions relevant to schizophrenia. U. 

MEYER*; S. GIOVANOLI; J. FELDON. ETH Zuerich. 

8:00 BB18 363.25 Early life environmental stress differentially 

affects frontal and lateral entorhinal glutamate and GABA 

transmission. A microdialysis study in two rat models of 

schizophrenia. S. D. O’SHEA; O. M. MCCABE; M. P. MORAN; 

A. T. BRADY; I. E. DESOUZA; W. T. O’CONNOR*. Univ. Col. 

Dublin, Univ. of Limerick. 

9:00 CC1 363.26 • Reduced levels of synaptic proteins 

and neurotransmitter receptors in the hippocampus of MAM 

treated rats correlates with disrupted synaptic transmission. 

E. HRADETZKY; V. LAKICS*; T. M. TSANG; T. M. 

SANDERSON; N. MALIK; E. HOLMES; M. J. O’NEILL; M. D. 

TRICKLEBANK; S. BAHN. Univ. of Cambridge, Eli Lilly and 

Co. Ltd, Imperial Col. London. 

10:00 CC2 363.27 A role for DNA methylation in the 

NMDA receptor antagonist-mediated loss of phenotype 

of parvalbumin-positive fast-spiking interneurons. M. 

BEHRENS*; A. HASENSTAUB; T. J. SEJNOWSKI. The Salk 

Inst. CNL-S. 

11:00 CC3 363.28 Perinatal stress elicits lasting epigenetic 

changes in mice: A potential model for schizophrenia. P. 

TUETING*; A. GUIDOTTI; F. MATRISCIANO; J. M. DAVIS. 

Coll Med, Univ. Illinois, Chicago. 

8:00 CC4 363.29 Variable prenatal stress results in 

impairments of sustained attention in a 5-choice serial 

reaction time task in rats. C. A. WILSON*; A. V. TERRY, Jr. 

Med. Col. of Georgia. 

9:00 CC5 363.30 Immune activation during pregnancy 

alters prepulse inhibition and short-term hippocampal synaptic 

plasticity of the adult offspring. J. G. HOWLAND*; B. N. 

CAZAKOFF; Y. ZHANG; C. A. THAI. Univ. Saskatchewan, 

Univ. of Saskatchewan. 

POSTER 

364. Anxiety Disorders: Animal Models 



8:00 CC6 364.1 Enhanced cannabinoid signaling alleviates 

the trauma-induced sleep symptoms in PTSD. S. KANTOR*; 

K. SPITZER; V. HUMLI; T. T. NGUYEN; A. SZOKE; J. 

HALLER. Inst. of Exptl. Medicine, Hungarian Acad. of Sci., 

Eotvos Lorand Univ., Semmelweis Univ. 

9:00 CC7 364.2 � Antalarmin reduces anxiety in the 

elevated plus maze but not latency to immobility in the forced 

swim task. R. STEEL; C. SEARY; A. PARR; A. D. STILLAR*; 

M. SAARI. Nipissing Univ. 

10:00 CC8 364.3 Olanzapine treatment significantly 

increases survival of BALB/cJ mice in the activity-based 

anorexia model. S. J. KLENOTICH*; M. P. SEIGLIE; S. C. 

DULAWA. Univ. of Chicago. 

11:00 CC9 364.4 The novel anxiolytic compound BNC210 

reverses the effects of anxiogenic compounds in the rat 

elevated plus maze. S. M. O’CONNOR*; B. HUYARD; S. 

WAGNER; E. ANDRIAMBELOSON; G. KREMMIDIOTIS. 

Bionomics Limited, Neurofit SAS. 

8:00 CC10 364.5 Targeting nicotinic receptors in OCD 

mouse model. S. M. CHOWDHURY*; J. KUSINA; M. K. 

SCHULTE; A. BULT-ITO. Univ. of Alaska Fairbanks. 

9:00 CC11 364.6 The Triple Test: Measuring anxiety and 

locomotion - Shining new light on old tests. L. M. FRASER*; A. 

HUSSIN; R. E. BROWN; A. HOLMES; A. RAMOS. Dalhousie 

Univ., Section on Behavioral Sci. and Genetics, Natl. Inst. on 

Alcoholism and Alcohol Abuse, Laboratório de Genética do 

Comportamentol, Univ. Federal de Santa Catarina. 

10:00 CC12 364.7 Validation of automated tracking in the 

light-dark exploration test for anxiety: Impact of light intensity, 

start position and zone composition in outbred NMRI and 

inbred BALB/c mice. C. DE WEERDT; E. L. GALLANTINE; T. 

F. MEERT; A. BOUWKNECHT*. Janssen. 

11:00 CC13 364.8 Effects of prenatal exercise and early 

social stress in male and female rat offspring. M. C. 

DAVIDSON*; A. P. SHERE; N. J. FALBO; B. M. CICCONE; H. 

N. RICHARDSON. Univ. of Massachusetts. 

8:00 CC14 364.9 • Natural variations in resiliency and 

fear extinction in the BALB/cByJ mice are associated with 

differences in social interaction. J. PEREZ*; V. RISBROUGH; 

S. POWELL; M. GEYER. Univ. of California San Diego. 

9:00 DD1 364.10 Individual differences in peritraumatic 

generalized fear as a predictor of post-traumatic stress 

disorder (PTSD) -like behaviors in rats. X. CHEN; Y. LI; S. LI*; 

G. J. KIROUAC. Univ. of Manitoba. 

10:00 DD2 364.11 Excitability of dorsal periaqueductal 

gray matter varies between genders and according to 

different phases of the estrous cycle. J. M. SANTOS*; M. L. 

BRANDÃO. Univ. of Sao Paulo. 

11:00 DD3 364.12 Effects of moderate intensity exercise on 

anxiety in male and female rats. A. JONES*; K. S. CURTIS. 

OSU Ctr. for Hlth. Sci. 

8:00 DD4 364.13 • Validation of a spontaneous canine 

model for testing anxiolytics. J. A. ARAUJO*; C. DE RIVERA; 

N. W. MILGRAM. Univ. of Toronto, CanCog Technologies Inc., 

CaCog Technologies Inc. 

9:00 DD5 364.14 Deficiency in endocannabinoid signaling 

in the nucleus accumbens induced by chronic unpredictable 

stress. W. WANG*; D. SUN; B. PAN; C. ROBERTS; X. SUN; 

C. HILLARD; Q. LIU. Med. Col. of Wisconsin. 

10:00 DD6 364.15 Volatile compounds in roasted coffee 

beans reduce the stress-induced hyperthermia and prolong 

the pentobarbital-induced sleep time in mice. Y. HAYASHI*; S. 

SOGABE; Y. HATTORI. Notre Dame Seishin Univ. 



POSTER 

365. Alcohol: Tolerance Dependence and Withdrawal 



8:00 DD7 365.1 GABA receptor subunit composition in 

A 

rat hippocampus changes after acute and chronic ethanol 

treatment. K. LINDEMEYER*; I. SPIGELMAN; R. W. OLSEN. 

UCLA. 

9:00 DD8 365.2 • � Chronic alcohol-induced plasticity 

of GABA A R is blunted in α4 subunit KO mice. K. KELSON; 

V. LIM; S. BUCLEY; K. JEONG; C. TU; A. BASA; T. LAM; I. 

SPIGELMAN; R. W. OLSEN; J. LIANG*. UCLA Sch. of Dent., 

David Geffen Sch. of Med. at UCLA, David Geffen Sch. of 

Med. At UCLA. 

10:00 DD9 365.3 Receptor phosphorylation accompanies 

ethanol-induced α4β3δ GABAR internalization. C. 

GONZALEZ*; R. W. OLSEN. Geffen Sch. of Medicine, UCLA. 

11:00 DD10 365.4 Ethanol-induced internalization of GABA A 

receptors is modulated by PKC drugs. Y. SHEN*; A. K. 

LINDEMEYER; I. SPIGELMAN; J. LIANG; R. W. OLSEN. 

David Geffen Sch. of Med. At UCLA, Sch. of Dent. at UCLA. 

8:00 DD11 365.5 Antecedent anxiety predicts compulsivelike 

alcohol drinking in rats. L. F. VENDRUSCOLO*; K. K. 

MISRA; E. BARBIER; M. HEILIG; E. P. ZORRILLA; G. F. 

KOOB. The Scripps Res. Inst., Natl. Inst. on Alcohol Abuse 

and Alcoholism. 

9:00 DD12 365.6 Alcohol addiction and RNA-editing of 

serotonin 2C receptor. Y. WATANABE*; K. YOSHIMOTO; H. 

TATEBE; M. KIMURA; M. TANAKA. Kyoto Pref. Univ. Med. 

10:00 DD13 365.7 • Methylene blue attenuates ethanol 

withdrawal (EW) induced mitochondrial respiration inhibition. 

X. JU*; D. METZGER; Y. WEN; S. YANG; J. SIMPKINS; M. 

JUNG. Univ. of North Texas Hlth. Sci. Ctr. 

11:00 DD14 365.8 • Kappa-opioid receptor antagonism in 

the nucleus accumbens shell selectively reduces excessive 

alcohol self-administration in dependent rats. K. A. NEALEY; 

A. W. SMITH; S. M. DAVIS; D. G. SMITH; B. M. WALKER*. 

Washington State Univ., Lundbeck Res. USA, Inc. 

8:00 EE1 365.9 Effects of chronic ethanol exposure on 

EAAT2 (GLT-1) expression in striatal regions of C57BL/6J 

mice. W. C. GRIFFIN*, III; P. J. MULHOLLAND; C. 

HAZELBAKER; K. HERRICK; H. BECKER. Med. Univ. South 

Carolina. 

9:00 EE2 365.10 Activation of the unfolded protein response 

in the nucleus accumbens of C57BL/6J and DBA mice 

during ethanol-induced withdrawal. D. L. OBERBECK; S. S. 

EDMUNDS; J. ERK; R. J. HITZEMANN*. Oregon Hlth. Sci. 

Univ., Oregon Hlth. Sci. Univ. Prof & Chair. 

10:00 EE3 365.11 � An assessment of the effects of 

pregnenolone sulfate and intoxicated practice on alcohol 

tolerance and consumption in swiss webster mice. K. 

MALETSKY*; M. ROSE-BAKER; M. AYE; A. MORRISON; K. 

CRONISE. Middlebury Col. 

11:00 EE4 365.12 Persistence of increased forebrain proopiomelanocortin 

(POMC) gene expression is consistent 

throughout prolonged imposed abstinence in ethanoldependent 

rats. D. D. RASMUSSEN*; C. L. KINCAID. 

VAPSHCS/Univ of Washington. 



8:00 EE5 365.13 • Gene expression analysis in the 

extended amygdala using a mouse model of dependenceinduced 

excessive ethanol drinking. C. CONTET*; O. 

GARDON; D. FILLIOL; G. F. KOOB; B. L. KIEFFER. Scripps 

Resch Inst., Inst. de Genetique et de Biologie Moleculaire et 

Cellulaire. 

9:00 EE6 365.14 Ethanol dependence alters behavioral 

responsiveness to forced swim stress in male c57bl/6j mice. 

T. L. DOREMUS-FITZWATER*; H. C. BECKER. Med. Univ. of 

South Carolina. 

10:00 EE7 365.15 Evaluation of ethanol dependence and 

relapse drinking in the BXD strain of mice. M. F. LOPEZ*; K. 

G. FERNANDES; C. S. HINDMAN; R. W. WILLIAMS; M. F. 

MILES; H. C. BECKER. Med. Univ. of South Carolina, Univ. of 

Tenessee Hlth. Sci. Ctr., Virginia Commonwealth Univ. 

11:00 EE8 365.16 � Sex differences in alcohol tolerance 

and consumption in C57BL/6J mice. M. AYE; A. MCNALLY; 

K. BROWN; N. DUPRE; C. HENSCHEN; V. HUDZIAK; A. 

SULLIVAN; K. WILLIAMS; K. LEE; F. SAEED; A. MORRISON; 

K. CRONISE*. Middlebury Col., Middlebury Coll. 

8:00 EE9 365.17 Stimulation of Group II metabotropic 

glutamate receptors attenuates alcohol reinstatement 

following intoxication and withdrawal. P. R. KUFAHL*; R. 

MARTIN-FARDON; F. WEISS. Scripps Res. Inst. 

9:00 EE10 365.18 Intra nucleus accumbens, but not 

systemic administration of 5HT2c receptor antagonist blocks 

the expression of behavioral sensitization to ethanol. A. L. 

ANDRADE*; K. P. ABRAHAO; M. L. O. SOUZA FORMIGONI. 

Univ. Federal De São Paulo. 

10:00 EE11 365.19 Selective suppression of escalated alcohol 

intake in rats and mice with a CRF-R1 antagonist in VTA but 

not DRN. L. S. HWA*; I. M. QUADROS; J. F. DEBOLD; K. A. 

MICZEK. Tufts Univ. 

11:00 EE12 365.20 Chronic alcohol exposure alters NMDA 

receptor function and synaptic plasticity in the prefrontal 

cortex. S. KROENER*; P. J. MULHOLLAND; H. C. BECKER; 

L. J. CHANDLER. Med. Univ. South Carolina. 

8:00 EE13 365.21 • Autoregulation of GDNF levels in 

the vetral tegmental area induces long-lasting inhibition 

of excessive alcohol consumption. S. BARAK*; S. 

AHMADIANTEHRANI; D. RON. Univ. of California, San 

Francisco. 

9:00 EE14 365.22 Differential effects of HIV-1 infection and 

alcoholism on resolving conflict from emotional words. E. M. 

MULLER-OEHRING*; T. SCHULTE; A. PFEFFERBAUM; E. 

SULLIVAN. Stanford Univ. Sch. of Med., SRI Intl. 

10:00 EE15 365.23 Chronic alcohol impairs Y-maze 

performance and increases forced swim depression scores in 

male rats. J. L. GOMEZ*; M. J. LEWIS; B. BAUCHNER; C. E. 

DALY; L. STAHL; V. N. LUINE. Hunter Col., The Grad. Ctr. of 

CUNY. 

11:00 EE16 365.24 GABAA receptor and alpha subunit 

densities are altered in the cerebellum in a monkey model 

of chronic ethanol self-administration. G. DOLSON*; A. T. 

DAVENPORT; K. A. GRANT; D. P. FRIEDMAN. WFU Sch. of 

Med., Oregon Hlth. & Sci. Univ. 

8:00 EE17 365.25 H-Ras: A new target for alcohol use 

disorders. S. BEN HAMIDA*; J. NEASTA; Q. YOWELL; S. 

CARNICELLA; D. RON. The Ernest Gallo Clin. and Res. Ctr., 

Univ. of California, San Francisco. 


Mon. AM

9:00 EE18 365.26 Selective impairment in discrimination of 

expression of emotion during acute alcohol withdrawal. I. M. 

WHITE; S. OSBORNE; J. FORMAN; J. DILLOW; D. BOOK; 

W. WHITE*. Morehead State Univ. 

10:00 FF1 365.27 Increased progenitor cell numbers in the 

hippocampus of rats during protracted abstinence following 

binge alcohol exposure. D. M. HAYES*; K. M. STURGEON; 

M. A. DEENY; K. NIXON. Univ. of Kentucky. 

11:00 FF2 365.28 Nicotinic receptors in the medial habenula/ 

interpeduncular axis influence the manifestations of alcohol 

withdrawal. E. E. PEREZ*; M. D. BIASI. Baylor Col. of Med. 

8:00 FF3 365.29 Effects of ethanol deprivation on 

extracellular dopamine levels in the medial prefrontal cortex of 

alcohol-preferring rats. E. A. ENGLEMAN; C. M. INGRAHAM; 

L. C. FLIGOR; W. J. MCBRIDE; J. M. MURPHY*. Indiana 

Univ. Sch. of Med., Sch. Sci. - IUPUI. 

9:00 FF4 365.30 Impairment of executive function following 

a history of ethanol dependence in rats. G. GONZALEZ- 

CUEVAS*; R. MARTIN-FARDON; F. WEISS. The Scripps 

Res. Inst. 

POSTER 

366. Neural Plasticity and Addiction II 



8:00 FF5 366.1 • Attenuation of addictive behaviors 

following induced neuroplasticity. A. J. LESSELYONG*; W. 

ROSELLINI; T. SCHALLERT; M. KILGARD. Neural Progenitor 

Consulting, Inc., Microtransponder, Inc., Univ. of Texas, UT 

Dallas. 

9:00 FF6 366.2 Glutamatergic phenotype evaluation of 

midbrain dopamine neurons by cellular quantitative RT-PCR 

from intact adult rat brain tissue. X. LI*; T. H. NG; H. WANG; T. 

YAMAGUCHI; M. MORALES. Natl. Inst. On Drug Abuse/IRP/ 

Neuronal Networks Section. 

10:00 FF7 366.3 Differential distribution of the two subtypes 

of glutamatergic neurons within the midbrain dopamine 

system. T. YAMAGUCHI*; X. LI; H. WANG; T. NG; B. LIU; M. 

MORALES. IRP, NIDA, NIH. 

11:00 FF8 366.4 Ventral tegmental input from the 

pedunculopontine and laterodorsal tegmental nuclei is 

dominated by glutamatergic and GABAergic, rather than 

cholinergic neurons. H. WANG*; A. CHAKRABORTI; T. NG; T. 

YAMAGUCHI; M. MORALES. IRP/NIDA/NIH. 

8:00 FF9 366.5 Glutamatergic neurons within the medial 

aspects of the dopamine area A10 are a major output to 

the medial prefrontal cortex in the rat. T. NG*; H. WANG; T. 

YAMAGUCHI; M. MORALES. IRP/NIDA/NIH. 

9:00 FF10 366.6 Prenatal stress exposure increases the 

excitation and abolishes endocannabinoid-mediated long-term 

depression in ventral tegmental area dopamine neurons. R. 

SHEN*; K. A. HAUSKNECHT; J. WANG; S. HAJ-DAHMANE. 

Univ. at Buffalo. 

10:00 FF11 366.7 Acute stress or dexamethasone blocks 

LTP of GABAergic synapses in the ventral tegmental area. N. 

M. GRAZIANE*; J. A. KAUER. Brown Univ. 

11:00 FF12 366.8 Morphine-induced insertion of 

GluR2-lacking AMPA receptors in the hippocampus: An 

electrophysiological study in vitro. G. PORTUGAL; Y. 

XIA; P. SHINNICK-GALLAGHER; J. LIU; J. MORON- 

CONCEPCION*. Columbia Univ. Med. Ctr. 

8:00 FF13 366.9 Molecular mechanisms underlying 

morphine-induced trafficking of AMPA receptors in the 

hippocampus. Y. XIA*; D. CABAÑERO; G. PORTUGAL; N. 

BJORKLUND; J. LIU; J. MORON-CONCEPCION. Columbia 

Univ. Med. Ctr. 

9:00 FF14 366.10 • Chronic morphine treatment impaired 

hippocampal ltp and spatial memory via accumulation of 

extracellular adenosine acting on adenosine a1 receptors. J. 

LIU*; G. LU; L. XU; Q. ZHOU. Shanghai Inst. Materia Medica, 

Kunming Inst. of Zoology, Chinese Acad. of Sci. Kunming, 

Yunnan, 650223. 

10:00 FF15 366.11 Fluorescent-activated cell sorting (FACS) 

to identify unique gene expression alterations in rat prefrontal 

cortex neurons functionally activated during heroin-seeking 

behavior. S. FANOUS*; D. GUEZ-BARBER; R. SCHRAMA; 

F. THEBERGE; Y. SHAHAM; B. T. HOPE. NIH, Nat’L Inst. On 

Drug Abuse, Yale Univ., Utrecht Univ. 

11:00 FF16 366.12 Nucleus accumbens neurons activated 

during context-specific sensitization have unique synaptic 

properties. E. KOYA*; S. A. GOLDEN; B. J. MATTSON; A. F. 

HOFFMAN; C. R. LUPICA; B. T. HOPE. NIDA. 

8:00 FF17 366.13 Cocaine self-administration reveals 

de novo D1/D2 reduction in NMDA-mediated excitatory 

transmission in the oval bed nucleus of the stria terminalis. M. 

KRAWCZYK*; X. MASON; E. C. DUMONT. Queen’s Univ. 

9:00 FF18 366.14 Involvement of the cerebellum in longterm 

cocaine-induced conditioned memory: Beyond the 

basal ganglia. M. MIQUEL*; D. VÁZQUEZ-SANROMÁN; 

C. SANCHIS-SEGURA; L. AGUIRRE-MANZO; G. CORIA- 

AVILA; R. TOLEDO; J. MANZO. Jaume I Univ., Univ. 

Veracruzana. 

10:00 FF19 366.15 Brain-derived neurotrophic factor 

(BDNF) alters AMPA receptor trafficking in primary cultures 

of rat nucleus accumbens neurons. J. M. REIMERS*; J. A. 

LOWETH; M. MILOVANOVIC; M. E. WOLF. Rosalind Franklin 

Univ. Med. Sci. 

11:00 FF20 366.16 Brain-derived neurotrophic factor (BDNF) 

and cocaine-induced AMPA receptor plasticity in the rat 

nucleus accumbens. X. LI*; M. R. DEJOSEPH; A. BAHI; J. 

DREYER; J. H. URBAN; M. E. WOLF. Rosalind Franklin Univ. 

of Med. and Sci., Univ. of Regensburg, Univ. of Fribourg. 

8:00 GG1 366.17 Role of kalirin-7 in behavioral sensitization 

to cocaine and the associated increase in AMPA receptor 

surface expression in the nucleus accumbens. X. WANG*; M. 

E. CAHILL; Z. XIE; J. A. LOWETH; P. PENZES; M. E. WOLF. 

Rosalind Franklin Univ. of Med. and Sci., Northwestern Univ. 

9:00 GG2 366.18 Group I metabotropic glutamate receptors 

regulate calcium-permeable AMPA receptors in the rat 

nucleus accumbens. J. A. LOWETH*; J. M. REIMERS; 

M. MILOVANOVIC; K. A. FORD; C. R. FERRARIO; J. 

E. MCCUTCHEON; M. MARINELLI; K. Y. TSENG; M. E. 

WOLF. Rosalind Franklin Univ. of Med. and Sci., The Univ. of 

Michigan. 

10:00 GG3 366.19 Reversible palmitoylation regulates 

surface stability of GluR1/3 AMPA receptors in striatal 

neurons in response to cocaine in vivo. L. MAO*; M. GUO; 

J. Q. WANG. Univ. Missouri Kansas City Sch. Med., Univ. of 

Missouri-Kansas City. 



POSTER 

367. Psychostimulants: Developmental Effects 



8:00 GG4 367.1 Developmental loss of dopamine 

D receptor activation alters intracellular signaling in the 

1 

forebrain. A. FREDERICK*; A. J. BAUCUM; R. J. COLBRAN; 

G. D. STANWOOD. Vanderbilt Univ. 

9:00 GG5 367.2 Effects of different protocols of paradoxical 

sleep deprivation on the amphetamine-induced acute 

locomotor stimulant effect and behavioral sensitization 

in adolescent and adult mice. S. R. KAMEDA*; D. F. 

FUKUSHIRO; T. F. TROMBIN; R. PROCÓPIO-SOUZA; R. C. 

CARVALHO; R. WUO-SILVA; R. A. RIBEIRO; R. G. BELLOT; 

R. FRUSSA-FILHO; S. TUFIK; V. D’ALMEIDA. Federal Univ. 

of São Paulo, Univ. Metodista de São Paulo. 

10:00 GG6 367.3 The combination of developmental 

amphetamine-type stimulants and barren cage alters 

corticosterone and neurochemical levels in rats. D. L. 

GRAHAM*; C. V. VORHEES; M. T. WILLIAMS. Cincinnati 

Children’s Res. Fndn., Univ. of Cincinnati. 

11:00 GG7 367.4 Effects of chronic oral methylphenidate 

exposure on body weight, food intake, circadian activity, 

open field activity and novel object recognition in rats. L. 

S. ROBISON*; M. ANANTH; S. JOHNSON; J. CLARK; J. 

MURMELLO; N. G. MALITSIS; G. WANG; J. M. SWANSON; 

J. K. ROBINSON; N. D. VOLKOW; P. K. THANOS. Dept. 

of Medicine, Brookhaven Natl. Lab., Lab. of Neuroimaging, 

NIAAA, NIH, Child Develop. Center, Univ. of California-Irvine, 

Dept. of Psychology, Stony Brook Univ. 

8:00 GG8 367.5 Chronic oral methylphenidate treatment 

induces morphological changes in the rat brain. A. G. 

WEBER*; F. DELIS; S. GRANT; G. WANG; N. D. VOLKOW; 

P. THANOS. Brookhaven Natl. Lab., Florida State Univ., Natl. 

High Magnetic Field Lab., Lab. of Neuroimaging, Stony Brook 

Univ. 

9:00 GG9 367.6 Differential effects of early 

methylphenidate exposure on cocaine induced locomotor 

activity and place conditioning in adulthood. P. N. 

AUGUSTYNIAK*; K. G. GREEN; A. ARVANITOGIANNIS. 

Concordia Univ. 

10:00 GG10 367.7 Effects of preweanling methylphenidate 

exposure on sucrose preference and novelty-induced 

locomotor activity. T. C. STICKNEY*; O. O. KOZANIAN; C. M. 

BRITT; T. S. DER-GHAZARIAN; C. A. CRAWFORD. California 

State Univ. 

11:00 GG11 367.8 Prepubertal methylphenidate exposure 

decreases sensitivity to the rewarding effects of cocaine in 

adult wild-type, but not in netrin-1 receptor deficient mice. J. 

K. ARGENTO*; A. ARVANITOGIANNIS; C. FLORES. McGill 

Univ., Concordia Univ. 

8:00 GG12 367.9 The adult phenotype of netrin-1 

receptor deficient mice is reversed by prepubertal 

administration of repeated amphetamine. L. YETNIKOFF*; A. 

ARVANITOGIANNIS; C. FLORES. Douglas Mental Hlth. Univ. 

Institute, McGill Univ., Concordia Univ. 

9:00 GG13 367.10 Repeated ecstasy is aversive and 

anxiogenic following drug abstinence in adolescent rats. B. 

M. COX; M. M. SHAH; M. P. GALLOWAY; D. M. THOMAS; S. 

A. PERRINE*. Wayne State Univ. Sch. of Med., Wayne State 

Univ. Eugene Applebaum Col. of Pharm. and Hlth. Sci., John 

D. Dingell VA Med. Ctr. 



10:00 GG14 367.11 Methaphetamine’s effect on striatum 

development in young adolescent mice is laterally asymmetric. 

T. JI*; J. FAULKNER IV; P. N. VENKATASUBRAMANIAN; A. 

M. WYRWICZ. Northshore Univ. Healthsystem, Pritzker Sch. 

of Medicine, Univ. of Chicago. 

11:00 GG15 367.12 In utero exposure to methamphetamine, 

but not alcohol or nicotine, decreases executive function in 

children. B. J. PIPER*; S. M. CORBETT; J. RABER. Oregon 

Hlth. Sci. Univ., Univ. of Puget Sound. 

8:00 GG16 367.13 Differential residual effects of cocaine 

on anxiety in high-fear and low-fear adolescent rats 

during withdrawal. A. C. SANTUCCI*; K. GALVIN; C. 

STAVROPOULOS; M. ROJAS. Manhattanville Coll. 

9:00 HH1 367.14 Binge cocaine administration in adolescent 

rats alters anxiety-related behavior and amygdala gene 

expression in adulthood. S. BRONSON*; Y. D. BLACK; A. V. 

NAYDENOV; F. VASSOLER; C. KONRADI. Vanderbilt Univ., 

Univ. of California-Irvine. 

10:00 HH2 367.15 Genetic influences on differential acute 

locomotor stimulation from cocaine in adolescent versus adult 

mice. J. A. ZOMBECK*; J. S. RHODES. Univ. Illinois, Univ. of 

Illinois. 

11:00 HH3 367.16 Cortical thickness analysis on rodent 

brains. J. LEE; L. COLEMAN; F. T. CREWS; M. MCMURRAY; 

J. JOHNS; M. STYNER; I. OGUZ*. Univ. of North Carolina At 

Chapel Hill. 

8:00 HH4 367.17 Brain structural and diffusion tensor 

abnormalities following prenatal cocaine exposure in rodents. 

M. S. MCMURRAY*; I. OGUZ; M. STYNER; Y. CAI; H. AN; H. 

YUAN; J. M. JOHNS. Univ. North Carolina at Chapel Hill. 

9:00 HH5 367.18 Automatic diffusion tensor image analysis 

of the rat brain at PND5 and PND14. I. OGUZ; F. BUDIN; 

J. LEE; M. MCMURRAY; J. M. JOHNS*, Ph.D.; H. AN; M. 

STYNER. Univ. North Carolina. 

10:00 HH6 367.19 Prenatal cocaine effects on neonatal 

white matter development. G. GERIG*; K. GREWEN; S. 

GOUTTARD; E. BITAUD; J. GILMORE; J. JOHNS. SCI Inst. 

Univ. of Utah, UNC Chapel Hill, Sch. of Med., SCI Institute, 

Univ. of Utah. 

11:00 HH7 367.20 Prenatal cocaine effects on infant brain 

development. S. GOUTTARD; K. GREWEN*; G. GERIG; J. 

GILMORE; E. BITAUD; J. JOHNS. SCI Institute, Univ. of Utah, 

Univ. of North Carolina, Univ. of North Carolina, Chapel Hill, 

Sch. of Med. 

POSTER 

368. Neural Mechanisms of Drug Addiction 



8:00 HH8 368.1 GABAergic afferents from the nucleus 

accumbens target non-dopaminergic neurons in the ventral 

tegmental area. Y. F. XIA; J. R. DRISCOLL; E. B. MARGOLIS; 

L. WILBRECHT; H. L. FIELDS; G. O. HJELMSTAD*. Ernest 

Gallo Clin. & Res. Ctr, UCSF. 

9:00 HH9 368.2 Cytochemically identified VTA GABA 

neurons are hyperpolarized by mu opioid receptor agonists 

and are physiologically similar to dopamine neurons. E. B. 

MARGOLIS*; B. TOY; M. MORALES; H. L. FIELDS. Ernest 

Gallo Clin. & Resch Ctr., IRP, NIDA, NIH, Univ. of CA San 

Francisco. 


Mon. AM

10:00 HH10 368.3 Multiple circuits for ventral tegmental 

area opioid reward. H. L. FIELDS*; J. M. MITCHELL; E. B. 

MARGOLIS. UCSF, Univ. of CA San Francisco. 

11:00 HH11 368.4 The histone methyltransferase G9a 

regulates morphine-induced behavioral plasticity. H. SUN*; I. 

MAZE; D. M. DIETZ; Z. A. EVANS; R. NEVE; V. ZACHARIOU; 

E. J. NESTLER. Mount Sinai Sch. of Med., The Rockefeller 

Univ., MIT. 

8:00 HH12 368.5 Role of BDNF in the VTA in regulating 

molecular and behavioral responses to morphine. J. KOO*; 

M. S. MAZEI-ROBISON; Q. LAPLANT; D. M. DIETZ; D. 

FERGUSON; M. LOBO; Y. N. OHNISHI; J. FENG; Y. H. 

OHNISHI; E. MOUZON; M. B. WILKINSON; Y. L. HURD; S. J. 

RUSSO; E. J. NESTLER. Mount Sinai Sch. of Med. 

9:00 HH13 368.6 Morphine induced changes in NMDAR1 

splicing. E. M. ANDERSON*; R. M. CAUDLE. Univ. of Florida. 

10:00 HH14 368.7 Effects of morphine, methadone and 

buprenorphine on heterodimerized μ-opioid receptor and 

opioid receptor-like 1 in the in vitro cell model. C. W. LEE; J. 

YAN; T. HUNG; Y. CHIANG; H. WANG; L. CHIOU; I. K. HO*. 

Natl. Hlth. Res. Inst., Chang Gung Univ. Sch. of Med., Natl. 

Taiwan Univ. 

11:00 HH15 368.8 Serum corticosterone increase is a useful 

indicator to quantify the magnitude of naloxone-precipitated 

morphine withdrawal in mice. S. KISHIOKA*; K. UENO; A. 

YAMAMOTO; C. YAMAMOTO; Y. KOBAYASHI; N. KIGUCHI; 

T. MAEDA. Wakayama Med. Univ. 

8:00 HH16 368.9 Transmission through dopamine D1 

versus D2 receptors in the basolateral amygdala represents 

an opiate addiction switching mechanism controlling opiate 

memory encoding in the drug naïve versus dependent state. 

A. LINTAS*; N. CHI; S. R. LAVIOLETTE. Western Ontario 

Univ. 

9:00 HH17 368.10 Role of spinal PI3K in the development 

of chronic morphine tolerance. F. E. ATIANJOH*; C. LEE; S. 

KAO; M. YASTER; E. GAUDA; Y. TAO. Johns Hopkins Univ. 

10:00 HH18 368.11 Orexins in the paraventricular nucleus of 

the thalamus (PVT) as a mediator of dysphoria in morphine 

withdrawal. Y. LI*; H. WANG; C. WEI; K. QI; N. SUI; G. 

KIROUAC. Inst. Psychol, CAS, Univ. of Manitoba. 

11:00 HH19 368.12 Dextromethorphan accelerate the 

extinction of morphine or fentanyl place preference 

conditioning. P. TAO*; F. LIN; P. LAW; H. H. LOH. Natl. Def. 

Med. Ctr., Univ. of Minnesota, Med. Sch. 

8:00 HH20 368.13 Impaired emotional behavior and 

serotonergic function during protracted abstinence from 

chronic morphine. C. GOELDNER*; P. LUTZ; E. DARCQ; 

D. CLESSE; A. OUAGAZZAL; B. L. KIEFFER. Hoffmann 

La Roche, Inst. de Génétique et de Biologie Moleculaire et 

Cellulaire, Inst. des Neurosciences Cellulaires et Intégratives. 

9:00 II1 368.14 Inhibition of TrkB expression in the ventral 

tegmental area prevents the shift from the drug naive to the 

drug dependent state. H. VARGAS-PEREZ*; R. TING-A-KEE; 

A. HEINMILLER; M. BUFALINO; L. CLARKE; J. DREYER; 

D. VAN DER KOOY. Univ. Toronto, Univ. of Toronto, Univ. of 

Fribourg. 

10:00 II2 368.15 Novel toll like receptor 4 (TLR4) 

involvement in drug reward. A. L. NORTHCUTT*; C. 

SFREGOLA; N. E. MILES; J. AMAT; S. T. BLAND; R. 

ROZESKE; M. R. HUTCHINSON; S. F. MAIER; K. C. RICE; 

L. R. WATKINS. Univ. of Colorado-Boulder, Univ. of Colorado 

Denver, Univ. of Adelaide, Natl. Inst. on Drug Abuse, Natl. Inst. 

on Alcohol Abuse, Alcoholism Natl. Inst. of Hlth. 

11:00 II3 368.16 • Altered functionality of dopamine 

receptors in adolescent mice during opioid withdrawal. R. S. 

HOFFORD; P. J. WELLMAN; S. EITAN*. Texas A&M Univ. 

8:00 II4 368.17 The kappa opioid receptor system 

regulates inhibitory transmission in rat central amygdala. N. 

W. GILPIN; M. ROBERTO; P. SCHWEITZER*. Scripps Res. 

Inst. 

9:00 II5 368.18 Spinal matrix metalloproteinase-9 

contributes to physical dependence on morphine in mice. 

W. LIU; Y. HAN; Y. LIU; A. SONG; B. BARNES; Y. WU; X. 

SONG*. Dept. of Neurobiology, Parker Univ. Res. Inst., 

Jiangsu Province Key Lab. of Anesthesiology, Xuzhou Med. 

Col. 

10:00 II6 368.19 Glutamatergic transmission is crucial 

for in vivo excitatory effect of morphine on mesencephalic 

dopaminergic neurons. M. JALABER*; J. COURTIN; O. 

MANZONI; F. GEORGES. INSERM U862 Neurocentre 

Magendie. 

11:00 II7 368.20 D-cycloserine facilitates extinction of 

withdrawal-associated cues in morphine-dependent rats. 

C. E. O’NEILL; M. L. LETENDRE; K. M. MYERS; W. A. 

CARLEZON, Jr.; R. K. BACHTELL*. Univ. of Colorado, 


8:00 II8 368.21 Nociceptin (N/OFQ) effects on cocaineinduced 

dopamine (DA) release in nucleus accumbens (NAcc) 

of rat. J. VAZQUEZ*; W. POLGAR; L. TOLL. SRI Intl. 

9:00 II9 368.22 C-fos activation in the periaqueductal grey 

following acute morphine-3ß-glucuronide administration. C. 

A. AROUT*; B. KEST; D. MCCLOSKEY. Queens Col, CUNY, 

Col. of Staten Island. 

10:00 II10 368.23 Opioid agonist-induced trafficking 

of GPR177 in rat striatal neurons. B. A. REYES*; R. 

LEVENSON; W. BERRETTINI; E. J. VAN BOCKSTAELE. 

Thomas Jefferson Univ., Penn State Col. of Med., Univ. of 

Pennsylvania Sch. of Med. 

11:00 II11 368.24 Modulation of mesocortical dopamine 

transmission by mu- and kappa-opioid receptors. H. A. 

TEJEDA*; K. SCHULTZ; V. CHEFER; T. SHIPPENBERG. 

NIDA IRP, Univ. of Maryland. 

8:00 II12 368.25 • The novel neuropeptide Y Y5 receptor 

antagonist, Lu AA33810, attenuates food deprivation-induced 

reinstatement of heroin seeking. U. SHALEV*; T. MARIC; M. 

W. WALKER; F. SEDKI. Concordia Univ., Lundbeck Research, 

USA. 

9:00 II13 368.26 Adult methamphetamine exposure does 

not alter morphine antinociception and tolerance. M. C. CYR; 

M. M. MORGAN*. Washington State Univ. 

10:00 II14 368.27 The amidated Substance P(1-7) fragment 

attenuates the development of morphine tolerance. A. 

CARLSSON; Q. ZHOU; R. FRANSSON; A. SANDSTRÖM; M. 

HALLBERG; F. J. NYBERG*. Uppsala Univ. 

11:00 II15 368.28 Acupuncture reduces withdrawal 

symptoms of morphine through the GABA receptors. J. LEE; 

R. ZHAO; B. LEE; J. LEE; W. CHEON; C. YANG*. Daegu 

Haany Univ., Mudanjiang Medial Univ. 

8:00 II16 368.29 Multiplex miRNA expression profiling 

related to the reduction in mesolimbic dopaminergic activity 

under a neuropathic pain-like state in rodents. S. IMAI*; M. 

NARITA; K. NIIKURA; M. NARITA; M. SAEKI; N. KUZUMAKI; 

T. SUZUKI. Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. 



POSTER 

369. Olfactory Bulb and Accessory Olfactory Bulb 



8:00 II17 369.1 Modulation of excitatory/inhibitory balance 

in the accessory olfactory bulb influences oscillatory neural 

activity in the accessory olfactory bulb of anaesthetised mice. 

E. LESZKOWICZ*; S. KHAN; S. NG; P. BRENNAN. Univ. of 

Bristol. 

9:00 II18 369.2 Calcium-activated non-selective cationic 

current underlies the persistent firing properties of accessory 

olfactory bulb mitral cells. G. SHPAK*; S. WAGNER. Univ. Of 

Haifa. 

10:00 II19 369.3 Differential distribution of olfactory nerve 

synapses on mouse olfactory bulb dopaminergic neurons. 

E. KIYOKAGE*; Z. SHAO; A. C. PUCHE; M. T. SHIPLEY; 

K. KOBAYASHI; K. TOIDA. Kawasaki Med. Sch., Univ. of 

Maryland, Sch. of Med., Fukushima Med. University, Sch. of 

Med. 

11:00 II20 369.4 Nicotinic receptors control the efficacy and 

timing of glomerular output in the mouse olfactory bulb. R. 

D. D’SOUZA*; S. VIJAYARAGHAVAN. UC Denver, Anschutz 

Med. Campus, Univ. of Colorado Denver, Anschutz Med. 

Campus. 

8:00 JJ1 369.5 Signal processing in juxtaglomerular 

neurons of an identified olfactory glomerulus. M. KOLLO*; D. 

SCHWARZ; I. FUKUNAGA; T. CUTFORTH; A. T. SCHAEFER. 

Max-Planck-Institute For Med. Res., Dept. of MCD Biol. 431 

Sinsheimer labs U.C. Santa Cruz. 

9:00 JJ2 369.6 Computational modeling of the rodent 

glomerular external tufted cell. W. E. SHERWOOD*; J. H. 

TIEN. Boston Univ., Ohio State Univ. 

10:00 JJ3 369.7 Synaptic circuits underlying the mitral cell 

response to olfactory sensory neurons inputs. M. NAJAC; D. 

DESAINTJAN*; L. REGUERO; P. GRANDES; S. CHARPAK. 

INSERM U603, CNRS UMR 8154, Univ. Paris Descartes, 

Basque Country Univ. 

11:00 JJ4 369.8 Odors sum linearly in time in the olfactory 

bulb. P. GUPTA*; U. S. BHALLA. Natl. Ctr. For Biol. Sci. 

8:00 JJ5 369.9 Physiological diversity within neural 

populations enhances coding of stimuli. S. J. TRIPATHY*; K. 

PADMANABHAN; N. N. URBAN. Carnegie Mellon Univ. 

9:00 JJ6 369.10 Lateral inhibition is modulated by the 

respiratory rhythm in the olfactory bulb. M. PHILLIPS*; R. 

N. S. SACHDEV; D. C. WILLHITE; G. M. SHEPHERD. Yale 

Univ., Yale Univ. Sch. of Med., Kavli Inst. for Neuroscience, 

Yale Sch. of Med. 

10:00 JJ7 369.11 Effects of sniffing on the temporal 

structure of mitral/tufted cell output from the olfactory bulb. R. 

M. CAREY*; W. E. SHERWOOD; M. WACHOWIAK. Boston 

Univ. 

11:00 JJ8 369.12 An invariant temporal code between 

passive breathing and active sniffing in the mammalian 

olfactory bulb. K. CURY*; N. UCHIDA. Harvard Univ. 

8:00 JJ9 369.13 � Imaging odor responses in the olfactory 

bulb of anesthetized and awake mice. D. G. BLAUVELT; M. 

WIENISCH; T. F. SATO; V. N. MURTHY*. Harvard Univ. 

9:00 JJ10 369.14 Optogenetic analysis of cortical feedback 

fibers in the rodent olfactory bulb. F. MARKOPOULOS*; S. 

HAESLER; N. UCHIDA; V. N. MURTHY. Harvard Univ. 



10:00 JJ11 369.15 Transformation of odour representation 

by synaptic inhibition in the mouse olfactory bulb. I. 

FUKUNAGA*; J. T. HERB; A. T. SCHAEFER. Max Planck Inst. 

For Med. Res. 

11:00 JJ12 369.16 Odor familiarization influences newborn 

periglomerular cells survival and spatial distribution in the 

adult olfactory bulb. S. BOVETTI*; A. VEYRAC; S. GARCIA; 

O. FRIARD; A. FASOLO; A. DIDIER; S. DE MARCHIS. Univ. 

Torino, Ctr. de Neurosciences Paris-Sud, Univ. Paris-Sud XI, 

Univ. Claude Bernard Lyon1, Univ. of Torino. 

8:00 JJ13 369.17 IgSF8: A developmentally and functionally 

regulated cell adhesion molecule found in synapses in the 

olfactory pathway. A. RAY*; H. TRELOAR. Yale Univ. 

9:00 JJ14 369.18 Role of electrical activity in circuit 

formation in the olfactory system. P. LORENZON; N. 

REDOLFI; C. LODOVICHI*. Fondazione per la Ricerca 

biomedica, VIMM, Fondazione Ricerca Biomedica-Onlus 

VIMM, CNR. 

10:00 JJ15 369.19 Effects of perinatal unilateral naris 

occlusion (UNO) on gene expression profiles in olfactory 

bulb of adult mice. D. M. COPPOLA*; C. T. WAGGENER. 

Randolph-Macon Col., Virginia Commonwealth Univ. 

11:00 JJ16 369.20 Vip is required for circadian rhythms in 

the mammalian olfactory system. J. KANG; D. GRANADOS- 

FUENTES; L. MARPEGAN; T. E. HOLY; E. D. HERZOG*. 

Washington Univ., Washigton Univ. 

8:00 KK1 369.21 Age-dependent effects of norepinephrine 

on GABAergic inhibition in the rat olfactory bulb could mediate 

a sensitive period of olfactory learning. S. PANDIPATI*; N. E. 

SCHOPPA. Univ. Colorado Denver - AMC, Univ. of Colorado 

Anschutz Med. Campus. 

POSTER 

370. Multisensory Interactions: Principles, Connections, 

Response Properties 



8:00 KK2 370.1 Anatomical connectivity patterns of the 

anterior ectosylvian sulcus: Implications for multisensory 

processes. J. KRUEGER*; M. C. FISTER; W. H. LEE; T. A. 

HACKETT; M. T. WALLACE. Vanderbilt Univ. 

9:00 KK3 370.2 The influence of spatial receptive field 

architecture on the temporal dynamics of multisensory 

interactions in the superior colliculus. D. GHOSE; M. C. 

FISTER; M. T. WALLACE*. Vanderbilt Univ. 

10:00 KK4 370.3 The effects of electrically stimulating the 

cochlea on neurons in the intermediate and deep layers of the 

superior colliculus. T. J. PERRAULT*, Jr.; B. A. ROWLAND; J. 

W. VAUGHAN; B. E. STEIN. Wake Forest Univ. Sch. of Med. 

11:00 KK5 370.4 Mechanisms underlying the temporal 

window of multisensory integration. R. L. MILLER*; B. A. 

ROWLAND; B. E. STEIN. Wake Forest Univ. 

8:00 KK6 370.5 The potency of multisensory integration 

in complex environments. S. PLUTA*; B. A. ROWLAND; T. R. 

STANFORD; B. E. STEIN. Wake Forest Univ. Sch. of Med. 

9:00 KK7 370.6 Subthreshold interactions in multisensory 

integration: From outputs to inputs. B. A. ROWLAND*; T. R. 

STANFORD; B. E. STEIN. Wake Forest Univ. 


Mon. AM

10:00 KK8 370.7 Developing, retaining, and generalizing 

multisensory integration after minimal sensory experience. J. 

XU*; L. YU; B. A. ROWLAND; B. E. STEIN. Wake Forest Univ. 

Sch. of Med. 

11:00 KK9 370.8 Experience enhances the potency of 

sensory inputs to multisensory superior colliculus neurons. 

L. YU*; T. J. PERRAULT, Jr.; B. A. ROWLAND; B. E. STEIN. 

Wake Forest Univ. Sch. of Med. 

8:00 KK10 370.9 Multisensory and unisensory neurons 

discharge differently to the same stimulus. L. KENISTON*; B. 

L. ALLMAN; M. A. MEREDITH. Virginia Commonwealth Univ. 

9:00 KK11 370.10 Influence of local inhibition on multisensory 

properties in a spiking network model of multisensory 

convergence. H. LIM; R. TOMPKINS; L. KENISTON; M. 

MEREDITH; K. CIOS*. Virginia Commonwealth Univ. 

10:00 KK12 370.11 A new theoretical framework for 

multisensory integration. M. W. HADLEY; E. R. REYNOLDS*. 

Lafayette Col. 

11:00 KK13 370.12 Controlling multi signal flow in neuronal 

networks. T. P. VOGELS*; W. GERSTNER. Columbia Univ., 

Ecole Polytechnique Federale de Lausanne. 

8:00 KK14 370.13 Information in a balanced network. D. G. T. 

BARRETT; P. E. LATHAM*. Gatsby Computat. Neurosci Unit. 

9:00 KK15 370.14 Long-range neocortical strong loops: 

Potential broadcasters of information between distributed 

processors across the cortical hierarchy. J. VEZOLI*; M. 

GARIEL; N. T. MARKOV; J. C. ANDERSON; R. DOUGLAS; 

K. A. C. MARTIN; K. KNOBLAUCH; H. KENNEDY. 

INSERM U846, Univ. de Lyon, UCBL, Netherlands Inst. for 

Neuroscience, RNAAS, Inst. of Neuroinformatics, Univ. ETH. 

10:00 KK16 370.15 Mean-field analysis of neural networks 

with uniform synapses: in search of the “right” regime. K. 

RAJAN*. Princeton Univ. 

11:00 KK17 370.16 Implications of single-neuron gain control 

for information transmission in networks. J. GJORGJIEVA; M. 

FAMULARE; R. MEASE; A. L. FAIRHALL*. Cambridge Univ., 

Univ. of Washington, Univ. Washington. 

8:00 KK18 370.17 Digital atlas of neuronal connections of the 

rat brain primary somatosensory cortex. I. M. ZAKIEWICZ*; Y. 

C. VAN DONGEN; T. B. LEERGAARD; J. G. BJAALIE. Univ. 

of Oslo. 

9:00 LL1 370.18 Somatotopic or spatiotopic? Frame of 

reference for localizing thermal sensations under thermotactile 

interactions. H. HO*; J. WATANABE; H. ANDO; M. 

KASHINO. NTT Comm Sci. Labs, Japan Society for the 

Promotion of Sci., ERATO Shimojo Implicit Brain Function 

Project, Tokyo Inst. of Technol. 

POSTER 

371. Striate Cortex: Plasticity and Reorganization 



8:00 LL2 371.1 • Visual deprivation drives cross modal 

synaptic plasticity in primary auditory cortex. E. R. PETRUS*; 

C. JACOBS; H. LEE. Univ. of Maryland. 

9:00 LL3 371.2 Homeostatic plasticity of inhibitory 

synapses in visual cortex. M. GAO*; L. SONG; H. LEE. Univ. 

of Maryland. 

10:00 LL4 371.3 Loss of patterned vision drives crossmodal 

synaptic plasticity. H. LEE*; K. HE. Univ. Maryland. 

11:00 LL5 371.4 • Characterization of visual cortex activation 

responses to tactile stimuli in late-blind retinitis pigmentosa 

subjects using fmri. S. CUNNINGHAM*; J. WEILAND; P. BAO; 

B. S. TJAN. USC. 

8:00 LL6 371.5 • Population receptive field mapping 

in human subjects with visual cortical lesions. A. 

PAPANIKOLAOU*; G. A. KELIRIS; X. PENG; Y. SHAO; 

E. KRAPP; E. PAPAGEORGIOU; U. SCHIEFER; N. K. 

LOGOTHETIS; S. M. SMIRNAKIS. Max-Planck Inst. For Biol. 

Cybernetics, Baylor Col. of Med., Ctr. for Ophthalmology. 

9:00 LL7 371.6 Assessing the spatio-temporal dynamics 

of visual receptive fields by fMRI. G. A. KELIRIS*; Y. SHAO; 

A. PAPANIKOLAOU; X. PENG; N. K. LOGOTHETIS; S. M. 

SMIRNAKIS. Max-Planck for Biol. Cybernetics, Baylor Collage 

of Med., Univ. of Manchester. 

10:00 LL8 371.7 Population receptive field mapping in a 

macaque monkey with macular degeneration. Y. SHAO*; G. A. 

KELIRIS; A. PAPANIKOLAOU; D. M. FISCHER; D. NAGY; H. 

JÄGLE; M. W. SEELIGER; M. AUGATH; N. K. LOGOTHETIS; 

S. M. SMIRNAKIS. Max Planck Inst. For Biol. Cybernetics, 

Inst. for Ophthalmic Research, Univ. of Tuebingen, Div. of 

Imaging Sci. and Biomed. Engineering, Univ. of Manchester, 

Departments of Neurosci. and Neurology, Baylor Col. of Med. 

11:00 LL9 371.8 Visual training paired with electrical 

stimulation of the basal forebrain induces long-term increase 

in neuronal reactivity of the rat primary visual cortex. M. 

GROLEAU*; J. I. KANG; A. TANG; L. TIMMER; F. DOTIGNY; 

C. CASANOVA; E. VAUCHER. Univ. De Montréal. 

8:00 LL10 371.9 Nuclear accumulation of CREB coactivator 

TORC1 in monkey primary visual cortex after 

monocular enucleation. E. N. WILSON; J. LALONDE; E. J. 

ECKBO; S. ZANGENEHPOUR; A. CHAUDHURI*. McGill 

Univ., Tufts Univ. 

9:00 LL11 371.10 REM sleep plays a role in ocular 

dominance plasticity consolidation. M. C. DUMOULIN*; J. 

SEIBT; S. J. ATON; T. M. COLEMAN; S. KIM; M. G. FRANK. 

Univ. of Pennsylvania. 

10:00 LL12 371.11 Rapid emergence of direction 

selective responses in ferret visual cortex without training 

geniculocortical synapses. R. J. CORLEW*; Y. LI; L. E. 

WHITE; D. FITZPATRICK. Duke Univ. 

11:00 MM1 371.12 Modulation of inter-laminar circuit 

activation by visual experience. A. MAFFEI*; L. WANG; A. 

FONTANINI. SUNY-Stony Brook. 

8:00 MM2 371.13 Delayed synaptic scaling in binocular 

visual cortex during monocular deprivation. M. E. LAMBO*; G. 

G. TURRIGIANO. Brandeis Univ. 

9:00 MM3 371.14 Structural basis for the role of inhibition 

in facilitating adult brain plasticity. J. L. CHEN*; W. C. LIN; J. 

W. CHA; P. T. SO; E. NEDIVI. Massachusetts Inst. Technol., 

Picower Inst. for Learning and Memory, Harvard Med. Sch. 

10:00 MM4 371.15 Simplification and rigidity of dendritic 

arbors in the aging mouse brain. R. EAVRI*; E. NEDIVI. 

Picower Inst. for Learning and Memory, MIT. 

11:00 MM5 371.16 Plasticity of orientation preference in 

mouse visual cortex. A. K. KREILE*; T. BONHOEFFER; M. 

HÜBENER. Max Planck Inst. of Neurobio. 

8:00 MM6 371.17 Impaired homeostatic regulation of 

primary visual cortex responsiveness in C57BL/6JOlaHsd 

mice. A. RANSON; C. E. CHEETHAM*; V. L. BUCHMAN; F. 

SENGPIEL; K. FOX. Cardiff Univ. 



9:00 MM7 371.18 Putative inhibitory neurons showed normal 

plasticity without plasticity of excitatory neurons in visual 

cortex of mice lacking Arc. H. SUGIHARA*; C. MCCURRY; M. 

SUR. MIT. 

10:00 MM8 371.19 Identification of plasticity related gene-1 

(PRG-1) as a candidate gene for critical period neuroplasticity 

in cat and mouse visual cortex. C. B. YANG; P. J. KISER; Y. T. 

ZHENG; G. D. MOWER*. Univ. Louisville Sch. Med. 

11:00 MM9 371.20 Overexpression of serum response factor 

in astrocytes improves neuronal ocular dominance plasticity 

in the ferret model of FASD. A. PAUL*; F. POHL-GUIMARES; 

T. E. KRAHE; R. J. COLELLO; W. WANG; C. L. LANTZ; W. 

CHOW; A. E. MEDINA. Virginia Commonwealth Univ. 

8:00 MM10 371.21 Adaptation modifies the organization 

of orientation preference maps in adult cat visual cortex. I. 

Region of interest excluding pinwheels. S. I. SHUMIKHINA*; 

A. VOSOUGHI; S. MOLOTCHNIKOFF. Univ. Montreal. 

9:00 MM11 371.22 Adaptation modifies the organization 

of orientation preference maps in adult cat visual cortex. II. 

Pinwheel reorganization. A. VOSOUGHI; S. I. SHUMIKHINA; 

C. MILLERET; S. MOLOTCHNIKOFF*. Univ. of Montreal, 

Collège de France. 

10:00 MM12 371.23 Rescue of visual cortex plasticity 

deficits in a mouse model of fetal alcohol syndrome using a 

phosphodiesterase type 1 inhibitor. C. LANTZ*; W. WANG; A. 

E. MEDINA. Virginia Commonwealth Univ. 

11:00 MM13 371.24 Visual hyperacuity and enhanced 

critical period plasticity in Neuroligin-3 mutant mice. J. J. 

LEBLANC*; Y. HONG; T. SUDHOF; J. SANES; T. HENSCH; 

M. FAGIOLINI. Children’s Hosp. Boston, Harvard Med. Sch., 

Harvard Univ., Stanford Univ., Childrens Hosp. Boston. 

8:00 MM14 371.25 Visual stimulation during locomotion and 

TrkB signaling promote recovery of adult visual cortex from 

prolonged deprivation. M. KANEKO*; M. P. STRYKER. Univ. 

of California. 

9:00 NN1 371.26 Interactions between spatial and temporal 

context in V1 orientation tuning. C. A. PATTERSON*; X. JIA; 

S. WISSIG; A. KOHN. Albert Einstein Col. of Med. 

POSTER 

372. Extrastriate Cortex: Visual Responses and Neural Coding 



8:00 NN2 372.1 • TMS to area LO disrupts object 

processing but facilitates scene processing. C. R. MULLIN; J. 

K. STEEVES*. York Univ. 

9:00 NN3 372.2 Local sensitivity to stimulus orientation 

and spatial frequency within the receptive fields of neurons 

in visual area 2 of macaque monkeys. B. ZHANG*; X. TAO; 

E. SMITH; I. OHZAWA; S. NISHIMOTO; Y. CHINO. Univ. 

of Houston, Nova Southeastern Univ., Osaka Univ., UC 

Berkeley. 

10:00 NN4 372.3 Computational model of feed-forward and 

feedback dynamics in ferret visual cortices. J. A. HERTZ*; S. 

PAPAIOANNOU; P. ROLAND. Univ. Copenhagen, Karolinska 

Inst. 



11:00 NN5 372.4 Stimulus strength modulates correlations 

of local neuronal populations in macaque area MT. L. 

BUSSE*; M. R. DALIRI; S. KATZNER; S. TREUE. Univ. 

Tuebingen, UCL Inst. of Ophthalmology, German Primate Ctr., 

Bernstein Ctr. for Computat. Neurosci., Iran Univ. of Sci. and 

Technol., Inst. for Res. in Fundamental Sci. 

8:00 NN6 372.5 A biologically plausible neural network for 

unsupervised learning of head-centered representations from 

visual input statistics under natural viewing conditions. S. T. 

PHILIPP; T. WACHTLER*. Ludwig-Maximilians-Univ Munich. 

9:00 NN7 372.6 Contributions of correlated noise and 

selective decoding to choice probabilities in area MSTd during 

multisensory heading perception. G. C. DEANGELIS*; Y. GU; 

D. E. ANGELAKI. Univ. Rochester, Washington Univ. Sch. 

Med. 

10:00 NN8 372.7 Spike count variability, noise correlations 

and choice probabilities: cortical vs. subcortical neurons. 

S. LIU*; Y. GU; G. C. DEANGELIS; D. E. ANGELAKI. 

Washington Univ. Sch. Med., Univ. of Rochester. 

11:00 NN9 372.8 Statistics of visual responses in primate 

inferotemporal cortex to object stimuli. S. R. LEHKY*; R. 

KIANI; H. ESTEKY; K. TANAKA. Salk Inst., RIKEN Brain Sci. 

Inst., Shaheed Beheshti Univ. Med. Sch., Stanford Univ. Med. 

Sch., Inst. for Res. in Fundamental Sci. 

8:00 NN10 372.9 Spatial and temporal scales of neuronal 

correlation in macaque V4. M. A. SMITH*; M. A. SOMMER. 

Univ. Pittsburgh, Duke Univ. 

9:00 NN11 372.10 Border ownership reflected in the gamma 

range power of the local field potential. R. VON DER HEYDT*; 

A. MARTIN. The Johns Hopkins Univ. 

10:00 NN12 372.11 Inferotemporal neurons signal perceptual 

prediction errors. T. MEYER*; C. R. OLSON. CNBC. 

11:00 NN13 372.12 Pairwise maximum entropy models explain 

correlated activity of neural populations in the inferior temporal 

cortex of macaque monkeys. H. SHIOZAKI*; T. MOTONAGA; 

H. TAMURA; I. FUJITA. Osaka Univ. 

8:00 NN14 372.13 Rapid rate modulation explains temporal 

coding in area MT. K. FALLEN*; G. M. GHOSE. Univ. of 

Minnesota, Twin Cities. 

9:00 OO1 372.14 • Rapid learning improves neuronal coding 

in macaque area v4. Y. WANG*; S. ALWIN; V. DRAGOI. UT 

medical school at Houston. 

10:00 OO2 372.15 The reversal visual cortical mechanism of 

functional organizations underlying kinetic contour processing 

in V1, V2 and V4 of rhesus macaques. X. AN; J. YIN; Y. PAN; 

X. ZHANG; H. GONG; Y. YANG; T. SHOU; W. WANG*. Sch. 

of Life Sciences, Univ. of Sci. and Technol. of China, Inst. 

Neurosci, Shanghai, CAS, Vision Res. Lab, Ctr. for Brain Sci. 

Research, Sch. of Life Sciences, Fudan Univ. 

11:00 OO3 372.16 Conditional Granger Causality for 

measuring directed influences among cortical regions from 

fMRI BOLD signals. W. TANG*; S. L. BRESSLER; C. M. 

SYLVESTER; G. L. SHULMAN; M. CORBETTA. Florida 

Atlantic Univ., Washington Univ. Sch. of Med. 

8:00 OO4 372.17 • Functional correspondence between 

cortical activity in non-human and human primate brain during 

natural vision. D. MANTINI*; H. KOLSTER; V. BETTI; M. G. 

PERRUCCI; G. ROMANI; G. A. ORBAN; M. CORBETTA; W. 

VANDUFFEL. Katholieke Univ. Leuven, Univ. “G. D’Annunzio”, 

Univ. Fndn. “G. D’Annunzio”, Washington Univ., Martinos Ctr. 

for Biomed. Imaging, Harvard Med. Sch. 


Mon. AM

9:00 OO5 372.18 Intra and inter network interaction 

revealed by spontaneous magnetoencephalographic activity. 

L. MARZETTI; S. DELLA PENNA; F. DE PASQUALE; D. 

MANTINI; A. Z. SNYDER; V. PIZZELLA; G. L. ROMANI; 

M. CORBETTA*. Gabriele D’Annunzio Univ., Gabriele 

D’Annunzio Univ. Fndn., K.U. Leuven Med. Sch., Washington 

Univ. 

10:00 OO6 372.19 Temporal dynamics of stimulus-driven 

attention shifts as studied through the combined use of ECoG 

and fMRI. A. L. DAITCH*; A. Z. SNYDER; S. ASTAFIEV; D. 

BUNDY; Z. FREUDENBURG; C. GAONA; B. HE; D. POPE; 

M. SHARMA; G. L. SHULMAN; M. E. RAICHLE; E. C. 

LEUTHARDT; M. CORBETTA. Washington Univ, St Louis. 

11:00 OO7 372.20 Spontaneous activity in visual cortex 

as a predisposing factor for visual perceptual learning. 

A. BALDASSARRE; C. M. LEWIS; G. COMMITTERI; A. 

Z. SNYDER*; G. L. ROMANI; M. CORBETTA. Dept. di 

Neuroscienze e Imaging Univ. “G. D’Annunzio”, ITAB, Inst. 

di Tecnologie Avanzate Biomediche Univ. “G. D’Annunzio”, 

Washington Univ. Sch. Med., Washington Univ. Sch. of Med. 

8:00 OO8 372.21 Modulation of MEG resting state networks 

during rest and natural vision. V. BETTI*; S. DELLA PENNA; 

D. MANTINI; F. DE PASQUALE; L. MARZETTI; G. ROMANI; 

M. CORBETTA. Istitute of Advanced Biomed. Technologies, 

Univ. of Chieti, Lab. for Neuro-psychophysiology, K. U. Leuven 

Med. Sch., Dept. of Radiology, Washington Univ., Departmnet 

of Neurology, Washington Univ. 

9:00 OO9 372.22 Interaction between the excitatory center 

and suppressive surround in monkey frontal eye field. W. M. 

JOINER*; J. CAVANAUGH; R. H. WURTZ. Natl. Eye Inst. 

10:00 OO10 372.23 The vestibular frame for visual 

perception of head rotation. A. V. VAN DEN BERG*; H. 

H. L. M. GOOSSENS; D. M. ARNOLDUSSEN. Radboud 

Univ. Nijmegen, Donders Inst. for Brain Cognition and 

Behaviour,Radboud Univ. Nijmegen Med. Ctr., Donders Inst. 

for Brain Cognition and Behaviour, Ctr. for Neuroscience, 

Radboud Univ. Nijmegen Med. Ctr. 

POSTER 

373. Visually Guided Reaching 



8:00 OO11 373.1 Parieto-premotor contributions to the 

planning and/or execution of reaching or grasping movements 

studied in humans with fMRI. M. HANSEN; N. MARCHAL; S. 

H. FREY*. Univ. Oregon. 

9:00 OO12 373.2 A neural network study of the 3D 

visuomotor transformation of velocity signals in manual 

tracking. G. LECLERCQ*; G. BLOHM; P. LEFEVRE. Univ. 

Catholique De Louvain, Queen’s Univ., Univ. catholique de 

Louvain. 

10:00 OO13 373.3 Reflexive control of human prospective 

catching. S. N. PERFILIEV*; J. WESSBERG. Göteborg Univ. 

11:00 OO14 373.4 Is there a natural speed of reaching 

movements? B. SHABBOTT*; P. MAZZONI. Columbia Univ. 

8:00 OO15 373.5 Behavioral regression in functional 

magnetic resonance image analysis of sensorimotor 

learning. N. M. SALOWITZ*; J. L. ZIMBELMAN; L. S. 

SIMO; A. J. SUMINSKI; R. A. SCHEIDT. Marquette Univ., 

LS Cleveland VA Med. Ctr., Case Western Univ., Cleveland 

Clin., Northwestern Univ., Univ. of Chicago, Rehabil. Inst. of 

Chicago, Med. Col. of Wisconsin. 

9:00 OO16 373.6 Short latency corrections during pointing 

to position perturbed targets. L. OOSTWOUD WIJDENES*; E. 

BRENNER; J. B. J. SMEETS. VU Univ. 

10:00 OO17 373.7 Invariance of planning noise to 

unperceived visuomotor perturbations. G. A. APKER*; C. P. 

KARIMI; C. A. BUNEO. Arizona State Univ. 

11:00 OO18 373.8 Motor specification processes in the 

dorsal and ventral premotor cortex (PMd and PMv) through 

distinct paths of information processing. T. YAMAGATA*; Y. 

NAKAYAMA; J. TANJI; E. HOSHI. Tamagawa Univ. 

8:00 PP1 373.9 Transfer to untrained pointing directions 

after adaptation to different visual rotations. S. WERNER*. 

German Sport Univ. 

9:00 PP2 373.10 Is the involvement of cognitive processing 

in a visuo-motor task dependent on time window for the task 

execution? H. KATSUMATA*. Daito-Bunka Univ. 

10:00 PP3 373.11 Chronometry of reach target selection in 

superior colliculus and dorsal premotor area. R. M. MCPEEK*; 

J. SONG. SUNY Optometry, Brown Univ. 

11:00 PP4 373.12 • � Healthy people prefer to look short 

and point blind when exposed to simulated hemianopia. A. G. 

MAHON*; J. TAYLOR; L. BROWN. Trent Univ. 

8:00 PP5 373.13 Anisotropic changes in task precision 

constraints do not lead to an anisotropic modulation of the 

hand trajectory control. M. TAGLIABUE*; E. DE VLUGT; F. 

C. T. VAN DER HELM; J. MCINTYRE. Univ. Paris Descartes, 

CNRS, Delft Univ. of Technol. 

9:00 PP6 373.14 Contributions of execution and planning 

noise to arm movement variability in 3D space. C. A. 

BUNEO*; G. APKER; T. DARLING. Arizona State Univ. 

10:00 PP7 373.15 Limits on action priming by pictures of 

objects. A. B. YU*; R. A. ABRAMS; J. M. ZACKS. Washington 

Univ. In St. Louis, US Army Res. Lab. 

11:00 PP8 373.16 • Developmental profiles of visually-guided 

reaching movements. L. C. PELLAND*; T. HERTER; N. 

CHOE; S. H. SCOTT. Queen’s Univ. 

8:00 PP9 373.17 Online updating of spatial and temporal 

aspects of manual interception movements. J. C. DESSING*; 

M. VESIA; X. YAN; J. D. CRAWFORD. York Univ., Canadian 

Action and Perception Network (CAPnet). 

9:00 PP10 373.18 Arm movement variability resulting from 

sensor and execution noise. Y. SHI*; C. BUNEO. Arizona 

State Univ. 

10:00 PP11 373.19 An adaptational model of time-to-contact 

prediction against multiple acceleration environment. H. 

KAMBARA*; K. OHISHI; Y. KOIKE. Tokyo Inst. Technol., 

Japan Sci. and Technol. Agency, CREST. 

11:00 PP12 373.20 Quanitative assessment of upper limb 

sensorimotor function in traumatic brain injury subjects using 

kinarm. C. T. DEBERT*; T. M. HERTER; S. P. DUKELOW. 

Univ. of Calgary, Queen’s Univ. 

8:00 PP13 373.21 • Cortico-cortical connections of the 

parietal area V6Av in the macaque monkey. L. PASSARELLI; 

M. GAMBERINI; S. BAKOLA; K. J. BURMAN; P. FATTORI; M. 

G. ROSA*; C. GALLETTI. Univ. of Bologna, Monash Univ. 



POSTER 

374. Pain: Other Analgesics 



8:00 PP14 374.1 Neurochemical profiles of the 

selective μ-opioid receptor agonist fentanyl: Simultaneous 

assessment with HPLC and 1H-MRS. G. M. MCKELVEY*; 

F. GHODDOUSSI; S. JUKANTI; K. SONI; H. MARSH; M. 

GALLOWAY. Wayne State Univ. 

9:00 PP15 374.2 Isobolographic analyses of gabapentindiacerein 

antinociceptive combination in the rat formalin test. 

L. D. GARCÍA-MORA; K. PONCE-CHÁVEZ; A. ZÚÑIGA- 

ROMERO; V. GRANADOS-SOTO; L. F. ORTEGA-VARELA*. 

Facultad de Químico-Fármaco-Biología, Univ. Michoacana de 

San Nicolás de Hidalgo (UMSNH), Dept. de Farmacobiología, 

CINVESTAV-IPN, Escuela De Enfermería Y Salud Publica, 

Univ. Michoacana De San Nicolás De. 

10:00 PP16 374.3 Tolerance effects of nsaids microinjected 

into periaqueductal gray, nucleus raphe and central amygdala. 

M. G. TSAGARELI*; N. TSIKLAURI; I. NOZADZE; G. 

GURTSKAIA; E. ABZIANIDZE. Beritashvili Inst. Physiol, Tbilisi 

State Med. Univ. 

11:00 PP17 374.4 Isobolographic analysis of the antiinflammatory 

effect of naproxen with tizanidine in the 

carrageenan-induced paw edema in rats. S. I. PATIÑO- 

CAMACHO*; R. M. MONTIEL-RUIZ; F. J. FLORES- 

MURRIETA; M. DECIGA-CAMPOS. Escuela Superior De 

Medicina, IPN, Unidad de Investigación en Farmacología, 

INER. 

8:00 PP18 374.5 The peripheral antinociceptive effect of 

the co administration of tizanidine and ketorolac in mice. 

L. GARCÍA-HERNANDEZ*; D. A. CASTRO-VIDAL; A. L. 

MARTÍNEZ-MARTÍNEZ; M. E. GONZÁLEZ-TRUJANO; F. 

J. LÓPEZ-MUÑOZ; M. DÉCIGA-CAMPOS. CINVESTAV 

Sede Sur, Facultad de Ciencias Químicas e Ingeniería, Univ. 

Autónoma de Baja California Campus Tijuana., Inst. Nacional 

de Psiquiatría “Ramón de la Fuente Muñiz”, Escuela Superior 

de Medicina, IPN. 

9:00 QQ1 374.6 Antinociceptive synergism of tramadol and 

diclofenac in formalin test in rat. R. M. MONTIEL-RUIZ*; S. I. 

PATIÑO-CAMACHO; F. J. FLORES-MURRIETA; M. DECIGA- 

CAMPOS. Escuela Superior De Medicina, IPN, Unidad de 

Investigación en Farmacología, INER. 

10:00 QQ2 374.7 Synergistic interaction between ketorolac 

whit tizanidine in the formalin test in mice. D. A. CASTRO 

VIDAL*; R. M. MONTIEL-RUIZ; J. M. CORNEJO-BRAVO; 

F. J. FLORES-MURRIETA; M. DECIGA-CAMPOS. Facultad 

de Ciencias Químicas e Ingeniería, Univ. Autónoma de 

Baja Califor, Escuela Superior de Medicina, IPN, Unidad de 

Investigación Farmacológica, Inst. Nacional de Enfermedades 

Respiratorias. 

11:00 QQ3 374.8 � Evaluation of antinociceptive effect of 

glucosamine-chondroitin sulfate and glucosamine-glycine 

coadministration in the formalin test. S. DECIGA-CAMPOS*; 

R. C. ANGELES-VAZQUEZ; M. DÉCIGA-CAMPOS. FCPYS, 

UNAM, FES-Zaragoza, UNAM, Escuela Superior de 

Medicina, IPN. 

8:00 QQ4 374.9 A bioflavonoid from rosemary, produces 

antinociceptive effect mediated by TRPV1 receptor in rats. A. 

L. MARTINEZ-MARTINEZ*; M. E. GONZALEZ-TRUJANO; F. 

J. LOPEZ-MUNOZ. CINVESTAV, Inst. Nacional de Psiquiatria 

Ramón de la Fuente Muñiz. 



9:00 QQ5 374.10 Neuropharmacological profile of affinin, 

compound isolated from heliopsis longipes extract. M. 

DECIGA-CAMPOS*; Y. RIOS; B. AGUILAR-GUADARRAMA. 

Escuela Superior De Medicina IPN, Univ. Autonoma del 

Estado de Morelos. 

10:00 QQ6 374.11 • ANG2002: A new Angiochem-modified 

neurotensin with increased brain penetration and analgesic 

properties. M. DEMEULE*; A. RÉGINA; C. THIOT; C. CHÉ; 

J. CURRIE; R. BÉLIVEAU; J. CASTAIGNE. Angiochem Inc., 

Univ. du Québec à Montréal. 

11:00 QQ7 374.12 Synergistic interaction between intrathecal 

gamma-aminobutyrate (GABA) receptor agonists and an 

N-methyl-D-aspartate (NMDA) receptor antagonist in rats with 

neuropathic spinal cord injury pain. A. T. HAMA*; J. SAGEN. 

Univ. Miami. 

8:00 QQ8 374.13 • Sodium channel inhibitors patterned on 

saxitoxin as diagnostics and therapeutics for the treatment 

of pain. J. V. MULCAHY; W. H. PARSONS; A. E. ONDRUS; 

B. M. ANDRESEN; D. BEHERA; A. HOEHNE; F. T. CHIN; D. 

C. YEOMANS; S. BISWAL; G. P. MILJANICH*; J. DU BOIS. 

Stanford Univ., Airmid Inc. 

9:00 QQ9 374.14 Cannabinoid receptor mediation of 

cannabinoid agonist effects in female vs. male rats. R. M. 

CRAFT*; J. D. LAGGART; K. T. TSUTSUI; J. W. HUFFMAN. 

Washington State Univ., Clemson Univ. 

10:00 QQ10 374.15 • Adenoviral gene transfer of dopamine 

beta-hydroxylase in the hypothalamus potentiates 

electroacupuncture analgesia in rats. J. LEE; E. CHUNG; M. 

HONG; M. SHIN; H. BAE*. BK21 Oriental Med. Sci. Ctr., Col. 

of Oriental Med. 

11:00 QQ11 374.16 • Oxytocin inhibits KCl induced intracellular 

calcium response in rats DRG neurons. S. HOBO; K. 

HAYASHIDA; C. M. PETERS*; J. C. EISENACH. Wake Forest 

Med. Sch. 

8:00 QQ12 374.17 • Production of chromaffin-like cells by 

cell reprogramming in vitro and its analgesic effects in vivo. 

T. QU*; G. SHI; K. MA; A. SHEN; J. SHEN; G. PAPPAS; J. 

CHENG. Univ. Illinois Chicago, Beijing Children’s Hosp., Dept. 

of Pain Management, The Cleveland Clin. 

9:00 QQ13 374.18 The effects of bupivacaine on 

spontaneous postsynaptic currents in dorsal horn neurons. 

K. FURUTANI; M. IKOMA*; H. ISHII; H. BABA; T. KOHNO. 

Niigata Univ. Grad Sch. Med. 

10:00 QQ14 374.19 Attenuation of win 55,212-2-induced 

hyperalgesia, tolerance, and reward by a melatonin analogue 

in rats. S. WANG; G. LIM; L. CHEN; J. MAO*. Mass Gen. 

Hosp, Massachusetts Gen. Hosp. 

11:00 QQ15 374.20 Neurochemical profile of the noradrenergic 

α2a receptor agonist dexmedetomidine. G. TOSHNIWAL; F. 

GHODDOUSSI; G. MCKELVEY; S. O. GIRGIS; H. MARSH*; 

M. P. GALLOWAY. Wayne State Univ. 

POSTER 

375. Pain Models: Behavior 



8:00 QQ16 375.1 Genetic dissection of light input pathways 

required for light associated allodynia using mutant mice. S. 

PARIKH*; A. MATYNIA; M. B. GORIN. UCLA. 


Mon. AM

9:00 QQ17 375.2 An opiate-dependent mouse model of light 

associated allodynia. A. MATYNIA*; S. PARIKH; B. CHEN; S. 

NUSINOWITZ; M. B. GORIN. UCLA. 

10:00 QQ18 375.3 • Depressive behaviours coincide with 

neuropathic pain in a chronic-relapsing model of experimental 

autoimmune encephalomyelitis (EAE). C. J. OLECHOWSKI; 

T. MUSGRAVE; B. J. KERR*. Univ. of Alberta. 

11:00 QQ19 375.4 Ketogenic diet-induced thermal 

hypoalgesia follows a delayed time course in comparison to 

ketosis in juvenile rats. D. N. RUSKIN*; T. A. C. S. SUTER; S. 

A. MASINO. Trinity Col. 

8:00 QQ20 375.5 Peripheral administration of botulinum 

toxin type A neurotoxin reverses trigeminal neuropathic pain 

symptoms. A. KUMADA; Y. MATSUKA*; I. SPIGELMAN; J. 

K. NEUBERT; T. A. NOLAN; Y. YAMAMOTO; K. SATOH; K. 

WATANABE; T. KUBOKI; K. OGUMA. Okayama Univ. Grad 

Sch. Med, Dent. & Pharmaceut, Div. Oral Biol. & Medicine, 

UCLA Sch. Dent., Col. Dentistry, Dept. Orthodontics, Univ. 

Florida. 

9:00 RR1 375.6 Adult neurogenesis and pain memory. S. 

A. LAUDENKLOS*; A. MARTIN-VILLALBA. DKFZ. 

10:00 RR2 375.7 Development of a novel device for 

measuring withdrawal latency by thermal stimulation in animal 

facial pain models using the Hargreaves plantar apparatus. 

F. G. GARRETT*; A. E. OVERMYER; L. A. VAUSE; J. L. 

HAWKINS; J. B. HAYDEN; P. L. DURHAM. Ctr. For Biomed. & 

Life Sci. - Missouri State Univ. 

11:00 RR3 375.8 Long-lasting pain hypersensitivity following 

ligation of the tendon of the masseter muscle in rats: A model 

of myogenic orofacial pain. W. GUO*; H. WANG; S. ZOU; F. 

WEI; R. DUBNER; K. REN. Dentl Sch, & Prog. in Neurosci. 

8:00 RR4 375.9 Characterization of an inflammatory 

mouse model of orofacial pain. M. ROMERO*; E. NGYEN; 

A. VIJJESWARAPU; H. DONG; A. CHARLES. NYU Col. of 

Dent., UCLA. 

9:00 RR5 375.10 Placebo analgesia in male and female rats 

using a novel facial operant testing paradigm. T. A. NOLAN*; 

N. P. MURPHY; J. K. NEUBERT. Univ. of Florida, Psychiatry & 

Biobehavioral Sci. 

10:00 RR6 375.11 Measuring orofacial mechanical 

hypersensitivity in the mouse using an operant behaviour 

model. A. J. DAVIES*; S. OH. Sch. of Dentistry, Seoul Natl. 

Univ. 

11:00 RR7 375.12 Age differences in the development of 

mechanical and thermal hyperalgesia after repeated acidic 

saline injection. J. D. MITZELFELT*; D. MORGAN; C. S. 

CARTER. Univ. Florida, Univ. of Florida Inst. on Aging. 

8:00 RR8 375.13 Neurosteroid replacement blocks 

development of stress-induced hyperalgesia during late 

dioestrus in female rats. A. J. DEVALL*; T. E. PIDGEON; T. A. 

LOVICK. Univ. of Birmingham. 

9:00 RR9 375.14 Effect of neurosteroid replacement on 

functional activation of the periaqueductal gray by acute 

anxiogenic stress during late dioestrus in female rats. T. A. 

LOVICK*; A. J. DEVALL. Univ. of Birmingham. 

10:00 RR10 375.15 • Characterization of a back incision model 

of post-surgical pain in the rat using a diode laser. L. POOK; 

T. L. HEALY; S. L. GOTTSHALL*. Algos Preclinical Services, 

Inc. 

11:00 RR11 375.16 • Estrogen attenuates nociceptive 

responses to carrageenan-induced inflammation in a timedependent 

manner. T. MATHEW*; K. SHIVERS; L. C. 

ABRAMS; T. SCHNIEDER; N. AMADOR; D. HUNTER; S. 

JENAB; V. QUINONES-JENAB. Hunter College, CUNY, The 

Grad. Sch. and Univ. Center, CUNY, NYSPI at Columbia Med. 

Ctr. 

8:00 RR12 375.17 Refined model of localized DRG 

inflammation: Effects on excitability of sensory neurons 

correlated with mechanical pain behavior. W. XIE; J. A. 

STRONG; J. ZHANG*. Univ. Cincinnati Coll Med. 

9:00 RR13 375.18 Effects of estrogen on inflammatory 

nociception-evoked pain-related behaviors: Studies using the 

force-plate actimeter. K. E. MCCARSON*; A. RALYA. Univ. 

Kansas Med. Ctr. 

10:00 RR14 375.19 Effect of diazepam and morphine on 

anxiety-like behaviours induced by chronic inflammatory 

pain. A. PARENT*; K. KIRBY; N. BEAUDET; G. DROLET; P. 

SARRET; L. GENDRON. Univ. de Sherbrooke, Univ. Laval. 

11:00 RR15 375.20 Exogenous cannabinoids in the nucleus 

cuneiformis alter the pain state as studied in acute and 

chronic models of pain. M. EBRAHIMZADEH-SARVESTANI*; 

A. HAGHPARAST. Neurosci. Res. Center, Shahid Beheshti 

Univ. of Med. Sci. 

8:00 RR16 375.21 Analysis of the eye-wiping response 

during the early age of rats. B. SANTIAGO*; I. E. DIAZ- 

MUÑOZ; A. DOMÍNGUEZ; P. CARRILLO; P. PACHECO; M. 

CAMACHO. Inst. Neuroetologia. Univ. Veracruzana, Inst. de 

Investigaciones Biomédicas, UNAM. 

9:00 RR17 375.22 Effect of alcohol on spinal nerve ligationinduced 

neuropathy in alcohol preferring rats. J. ORDUNA*; 

N. WALEH; R. L. BELL; J. MONTENEGRO; N. ZAVERI; 

L. TOLL. SRI Intl., Indiana Univ. Sch. of Med., Astraea 

Therapeut. 

10:00 RR18 375.23 Validation of inflammation-induced 

hyperalgesia in the paw pressure model across multiple rat 

strains. A. BOUWKNECHT; A. A. MEGENS*; A. S. LESAGE. 

Janssen. 

11:00 RR19 375.24 Pruritic and nociceptive behavioral 

responses elicited by PAR2 and PAR4 agonist peptides in 

mice. S. G. SHIMADA*; R. H. LAMOTTE. Yale Univ. Sch. 

Med. 

8:00 RR20 375.25 Surveying acute morphine hyperalgesic 

magnitude in inbred mouse strains. A. R. WAXMAN*; M. 

CALDWELL; C. AROUT; B. KEST. Grad. Center, CUNY, Col. 

of Staten Island/City Univ. of New York. 

POSTER 

376. Neuropathic Pain: Ion Channels 



8:00 SS1 376.1 • Intraepidermal axonal swellings in 

experimental diabetic neuropathy are predictive of neuropathic 

pain. C. C. TOTH*; C. ELLIS; N. PRADZINSKY; A. HERRING; 

W. H. FREY, II. Univ. Calgary, Univ. of Minnesota. 

9:00 SS2 376.2 TRESK channel is involved in DRG 

sensory neuron hyperexcitability following nerve injury. X. 

GASULL*; A. TULLEUDA; B. COKIC; M. MORALES; J. 

SERRA. Univ. Barcelona, Med. Sch., Barcelona Sci. Park. 



10:00 SS3 376.3 Differential modulation of sodium 

channels in naïve and nerve-injured dorsal root ganglia 

neurons by lacosamide. T. HAGENACKER*; N. SCHÄFER; 

D. BÜSSELBERG; M. SCHÄFERS. Univ. Clin. Essen; Dept. 

of Neurol., Weill Cornell Med. Col. at Qatar, Educ. City, POB 

24144. 

11:00 SS4 376.4 The effects of GABA-A alpha2/3 positive 

allosteric modulators in preclinical neuropathic pain models. S. 

NICKOLLS*; R. FISH; H. MACE; A. MOSS; G. MCMURRAY; 

J. NICHOLSON; T. PITCHER; D. RICHARDSON; C. 

SWEATMAN; R. KINLOCH. Pfizer. 

8:00 SS5 376.5 Biotechnology strategies for targeting 

Nav1.8 functional expression demonstrate therapeutic 

opportunity for neuropathic pain. I. NISHIMURA*; S. 

RUANGSRI; A. LIN; I. SPIGELMAN. Weintraub Center, UCLA 

Sch. of Dent. 

9:00 SS6 376.6 Sigma receptor agonists inhibit voltagegated 

calcium current in rat sensory neurons. H. WU; Q. 

TANG; V. ZOGA*; W. KWOK; Q. HOGAN. MEDICAL COLL 

WISCONSIN. 

10:00 SS7 376.7 DRG Aβ/Aα neurons upregulate NaV1.7 

during neuroma formation after nerve ligation and keratinocyte 

engraftment. E. J. ARROYO*; C. RADTKE; J. D. KOCSIS. 

Yale Univ. Sch. of Medicine/VA CT Healthcare Syst., 

Hannover Med. Sch. 

11:00 SS8 376.8 Diminished glycinergic inhibitory input to 

spinal dorsal horn neurons through KCC2 downregulation 

and NMDA-calpain activation in neuropathic pain. H. ZHOU; 

H. BYUN; H. CHEN; S. CHEN; H. PAN*. Univ. Texas-MD 

Anderson Cancer Ctr. 

8:00 SS9 376.9 Epigenetic gene silencing via NRSF in 

chronic neuropathic pain. H. UCHIDA*; H. UEDA. Nagasaki 

Univ. Grad. Sch. of Biomed. Sci. 

9:00 SS10 376.10 Inhibitors of casein kinase 1 epsilon are 

effective in blocking pain in neuropathic mice without showing 

any appreciable side effect in normal mice. T. TANABE*; E. 

SAKURAI; T. KURIHARA; K. KOUCHI; H. SAEGUSA; S. 

ZONG. Tokyo Med. & Dent. Univ. Grad Sch. Med. 

10:00 SS11 376.11 Involvement of peripheral ATP and P2X 3 

purinoceptor in pain-related behavior produced by orthotopic 

melanoma inoculation in mice. T. ANDOH*; M. FUJITA; A. 

SASAKI; S. IKUO; Y. KURAISHI. Univ. Toyama. 

11:00 SS12 376.12 Functional modulation of p2x4 receptorchannels 

by udp-activated p2y6 receptors. L. BERNIER*; 

E. BOUE-GRABOT; P. SEGUELA. McGill Univ., Univ. Victor 

Segalen Bordeaux 2. 

8:00 SS13 376.13 Effect of peripheral nerve injury on Icrac 

in rat sensory neurons. H. WU*; M. L. Y. BANGARU; G. 

GEMES; W. KWOK; Q. H. HOGAN. Med. Col. Wisconsin, 

Dept. Anesthesiology, Res. M4280. 

9:00 SS14 376.14 Reopening of ATP-sensitive potassium 

channels reduces neuropathic hyperalgesia via improving 

spinal astroglial gap junctional communication. X. WU; W. 

LIU*; Y. LIU; X. SONG. Parker Univ. Res. Inst., State Key Lab. 

of Pharmaceut. Biotechnology, Nanjing Univ. 

10:00 SS15 376.15 Accumulation of Kv7.2 channels on 

putative ectopic transduction zones of axotomized fibres from 

mice nerve end neuromas. C. ROZA*; J. A. LOPEZ-GARCIA. 

Univ. de Alcalá. 



11:00 SS16 376.16 Enhanced excitability and altered 

expression of voltage-gated potassium currents of neurons in 

a compressed dorsal root gangliion: A murine model of lumbar 

radicular pain. N. FAN*; P. SIKAND; D. F. DONNELLY; C. MA; 

R. H. LAMOTTE. Yale Univ. Sch. of Med. 

8:00 SS17 376.17 Attenuation of neuropathic pain by 

impaired Ca 2+ signaling in mutant mice lacking the Tyr- 

1472 phosphorylation site of the NR2B. S. MATSUMURA*; 

S. KUNORI; T. NAKAZAWA; T. ABE; T. YAMAMOTO; T. 

KATANO; M. WATANABE; E. OKUDA-ASHITAKA; S. ITO. 

Kansai Med. Univ., Inst. of Med. Science, The Univ. of Tokyo, 

Hokkaido Univ. Sch. Med. 

9:00 SS18 376.18 Calcium-dependent regulation of calcium 

currents in rat primary afferent neurons: Effect of injury and 

role of CaMKII. Q. TANG*; H. WU; W. KWOK; Q. HOGAN. 

Med. Col. of Wisconsin. 

10:00 SS19 376.19 Computational model of injury-induced 

changes in primary afferent excitability. Y. RHO*; S. A. 

PRESCOTT. Univ. of Pittsburgh. 

POSTER 

377. Cortical Reorganization and Plasticity 



8:00 SS20 377.1 Pattern of interhemispheric connections 

between forelimb representations in rat barrel field cortex. T. 

DECOSTA-FORTUNE; C. LI*; A. CURRY; R. WATERS. Univ. 

of Memphis, Univ. Tennessee. 

9:00 TT1 377.2 • � Plasticity in deafferented trigeminal 

pathway induced by electrical stimulation of peripheral 

nerve. C. HERRERA-RINCÓN; C. TORETS; A. SANCHEZ- 

JIMENEZ; P. GUILLÉN; F. PANETSOS*. Complutense Univ. 

of Madrid, European Med. Traumatological & Orthopedic 

Rehabil. Ctr. - CEMTRO. 

10:00 TT2 377.3 Can the degradation of perineuronal nets 

alter the activity of local inhibitory circuits in the barrel cortex? 

C. A. GOLLNICK; Q. WANG; S. D. KOENIG; D. C. MILLARD; 

R. V. BELLAMKONDA; G. B. STANLEY*. Georgia Inst. 

Technol. & Emory Univ. 

11:00 TT3 377.4 The time course of cortical reorganisation 

following a period of synchronised muscle stimulation. J. 

SHEMMELL*; S. MADHAVAN; Z. A. RILEY. The Univ. of 

Otago, Rehabil. Inst. of Chicago, Indiana University-Pudue 

Univ. Indianapolis. 

8:00 TT4 377.5 Chronic two-photon calcium imaging of 

stability and plasticity of sensory representations in mouse 

barrel cortex. D. J. MARGOLIS*; H. LÜTCKE; F. HAISS; B. 

WEBER; S. KÜGLER; M. T. HASAN; F. HELMCHEN. Univ. 

Zurich, Univ. Göttingen, Max Planck Inst. Med. Res. 

9:00 TT5 377.6 Absence of cortical thickening in people 

with migraine as compared to controls. R. DATTA*; J. A. 

DETRE; B. L. CUCCHIARA; G. K. AGUIRRE. Univ. of 

Pennsylvania. 

10:00 TT6 377.7 Dynamics of dynamics: The within-session 

variability of human somatosensory neocortical oscillations 

and evoked responses. Q. WAN; C. KERR; D. PRITCHETT; 

M. HAMALAINEN; C. I. MOORE*; S. R. JONES. MIT, Harvard 

Med. Sch., Massachusetts Gen. Hosp. 


Mon. AM

11:00 TT7 377.8 Trigeminal intersubnuclear neurons: 

morphometry, topology and input-dependent structural 

plasticity in adult rats. Y. B. MARTIN; P. NEGREDO; J. 

VILLACORTA; C. AVENDANO*. Univ. Autonoma Fac Med., 

Inst. Teofilo Hernando, Inst. Pluridisciplinar. 

8:00 TT8 377.9 Transection of the infraorbital nerve 

induces rewiring of afferent fibers in the somatosensory 

thalamus of mice. Y. TAKEUCHI*; Y. NAGUMO; Y. 

KATAYAMA; K. IMOTO; Y. KAWAKAMI; M. MIYATA. Tokyo 

Women’s Med. Univ., Sch. of Life Sci., SOKENDAI, Natl. Inst. 

Physiol. Sci. 

9:00 TT9 377.10 The effects of tactile stimulation upon 

indices of neuroplasticity. D. SLIZ*; F. AL-SHAMMARI; K. 

BOCZAR; S. HAYLEY. Carleton Univ. 

10:00 TT10 377.11 Demonstration of reorganization plasticity 

in the visual cortex of the adult rat after optic nerve crush with 

a single-cell-resolution metabolic mapping and tracing study. 

T. MACHARADZE*; R. PIELOT; T. WANGER; H. SCHEICH; 

E. GUNDELFINGER; J. GOLDSCHMIDT; M. R. KREUTZ. 

Leibniz-Institute For Neurobio. 

11:00 TT11 377.12 Modifications of intracortical connections 

following traumatic brain injury. S. L. JULIANO*; M. 

SHINDELL; S. C. SCHWERIN. USUHS. 

8:00 TT12 377.13 Targeted microstroke to the mouse 

somatosensory cortex causes bilateral alterations in 

spontaneous cortical activity as assessed using voltagesensitive 

dye imaging. M. FINGAS*; M. H. MOHAJERANI; K. 

AMINOLTEJARI; T. H. MURPHY. Univ. of British Columbia. 

9:00 TT13 377.14 Voltage sensitive dye imaging and local 

field potential recording reveals novel ipsilateral cortical and 

subcortical pathways after large cortical stroke in mice. K. 

AMINOLTEJARI*; M. FINGAS; M. H. MOHAJERANI; C. E. 

BROWN; T. H. MURPHY. Univ. British Columbia, Univ. of 

British Columbia, Univ. of Victoria. 

POSTER 

378. Motor Neurons: Exercise, Injury, and Disease 



8:00 TT14 378.1 Attenuation of age-related changes in 

neuromuscular synapses by caloric restriction and exercise. 

H. KANG*; G. VALDEZ; J. C. TAPIA; F. H. GAGE; J. R. 

SANES; J. W. LICHTMAN. Harvard Univ., Salk Inst. for Biol. 

Studies. 

9:00 TT15 378.2 The effect of 7 days of daily treadmill 

exercise on gene expression in large and small lumbar dorsal 

root ganglion neurons. N. R. PADDOCK*; P. SHEPPARD; P. F. 

GARDINER. Spinal Cord Res. Centre, Univ. of Manitoba. 

10:00 TT16 378.3 • Analysis of the interaction between 

botulinum neurotoxin type A and fibroblast growth factor 

receptor type 3 in neuronal cells using cross correlation 

raster imaging correlation spectroscopy. P. E. GARAY; J. A. 

ROSS; B. P. S. JACKY; D. J. WILLIAMS; M. A. GILMORE; 

J. V. ORDAS; L. E. STEWARD; R. AOKI; E. FERNANDEZ- 

SALAS*. Allergan Inc., Univ. of Hawaii. 

11:00 TT17 378.4 Effect of exercise on recovery from 

botulinum neurotoxin-induced paralysis. J. P. APLAND*; T. 

M. FERRARA; F. P. BRABAZON; T. M. MYERS; M. ADLER. 

USAMRICD. 

8:00 TT18 378.5 Passive heat stress and neuromuscular 

training influence motor cortical excitability of the FDI muscle. 

A. E. LITTMANN*; J. S. H. CHANG; C. L. MCHENRY; E. 

HOUSKA; S. HUEY; S. WAGGONER; R. K. SHIELDS. Univ. 

of Iowa. 

9:00 TT19 378.6 Heat stress influences neuromuscular 

control during a novel weight-bearing task. C. L. MCHENRY*; 

A. E. LITTMANN; S. CHANG; M. C. IVEY; H. L. SCHIRMER; 

J. D. VELTRI; R. K. SHIELDS. Univ. of Iowa. 

10:00 TT20 378.7 Upregulation of the serotonergic receptors 

in motoneurons following chronic exercise. J. WIENECKE*; H. 

AI; T. PLOUG; M. ZHANG. Univ. Copenhagen. 

11:00 UU1 378.8 Discharge properties and persistent 

currents in hindlimb motoneurons of rats with incomplete 

spinal cord injury. V. V. TURKIN; D. O’NEILL; S. 

SUBRAMANIAN; B. K. HILLEN; M. D. FAIRCHILD; A. 

IARKOV; R. JUNG; T. M. HAMM*. Barrow Neurolog. Inst., 

Arizona State Univ. 

8:00 UU2 378.9 Extracellular ATP enhances excitatory 

transmission by activating P2X and P2Y 1 receptors in rat 

spinal ventral horn neurons. T. FUJITA*; T. AOYAMA; S. 

KOGA; T. NAKATSUKA; S. UEMURA; T. YASAKA; E. 

KUMAMOTO. Dept. Physiol., Fac. Med., Saga Univ., Dept. 

Neurosci., Kansai Univ. of Hlth. Sci. 

9:00 UU3 378.10 Mu opioid receptor agonist modulates 

synaptic transmission to neonatal rat spinal ventral horn 

neurons but does not affect neuronal death induced by 

experimental ischemia. H. HONDA; Y. KAWASAKI; H. BABA*; 

T. KOHNO. Niigata Univ, Sch. Med. 

10:00 UU4 378.11 • Anodal dorsal premotor cortex (PMD) 

transcranial direct current stimulation (tDCS) may alter motor 

function in chronic subcortical stroke patients- Preliminary 

results. T. HODICS*; J. PEZZULLO; K. JABBAR; P. S. SMITH. 

Univ. Texas Southwestern, Georgetown Univ. 

11:00 UU5 378.12 Heterozygous Hsp60 knock-out mice 

represent a model of hereditary spastic paraplegia type13. R. 

MAGNONI*; J. PALMFELDT; M. WEST; E. FÜCHTBAUER; 

T. CORYDON; J. CHRISTENSEN; P. BROSS. Res. Unit For 

Mol. Med. Aarhus Univ. Hospital, Skejby, Inst. of Anat., Inst. of 

Mol. Biol., Dept. of Human Genet. 

8:00 UU6 378.13 Muscle fatigability is greater in hand 

muscles of combat veterans with post-traumatic stress 

disorder. M. L. KELLER*; B. SCHLINDER-DELAP; R. DOYEL; 

G. LARSON; S. K. HUNTER. Marquette Univ., VA Med. Ctr. 

9:00 UU7 378.14 Changes in the Primary Face Motor 

Cortex associated with orthodontic tooth movement. M. 

SOOD*; J. LEE; A. METAXAS; B. J. SESSLE. Fac. of Dent. 

10:00 UU8 378.15 Mandibular implant-supported 

overdentures change chewing-induced regional brain activity 

in edentulous patients. K. KIMOTO*; Y. ONO; A. TACHIBANA; 

Y. HIRANO; A. OHNO; N. HORI; T. OTSUKA; T. OBATA; M. 

ONOZUKA. Kanagawa Dent. Col., Long Island Univ., NIH, 

Natl. Inst. of Radiological Sci. 



POSTER 

379. Muscle Physiology and Biochemistry 



8:00 VV1 379.1 Gender differences in morphology and 

contractility of the iliofibularis muscle in the lizard Sceloporus 

torquatus. E. QUINTANA; J. MORALES; M. MARTÍNEZ- 

GÓMEZ; J. MANJARREZ; O. MONROY; U. AGUILERA- 

REYES; V. FAJARDO*. Univ. Autónoma del Estado de 

México, Univ. Autónoma Del Estado De México, Univ. 

Nacional Autónoma de México. 

9:00 VV2 379.2 Fatigue and muscle fiber type composition 

of fast muscles in the chronically undernourished rat during 

postnatal development. A. RUIZ-ROSADO; B. SEGURA*; 

J. GUADARRAMA; S. MARISCAL; I. JIMENEZ-ESTRADA. 

CINVESTAV, FES-Iztacala, UNAM. 

10:00 VV3 379.3 Reproductive experience, estrogen 

and striated pelvic- and perineal-striated muscles in female 

rabbits. K. LÓPEZ-GARCÍA; F. CASTELÁN; D. L. CORONA- 

QUINTANILLA; E. CUEVAS; I. JIMÉNEZ; M. MARTINEZ- 

GOMEZ*. Univ. Autónoma De Tlaxcala, Cinvestav-IPN, Ctr. 

Tlaxcala De Biología De La Conducta/Universidad Autónoma 

De Tlaxcala, Inst. de Investigaciones Biomédicas-UNAM. 

11:00 VV4 379.4 Stability of myosin heavy chain 

composition of the macaque tongue muscle styloglossus with 

aging. M. DAUGHERTY; Q. LUO; A. J. SOKOLOFF*. Emory 

Univ. 

8:00 VV5 379.5 Uric acid enhances running endurance in 

mice. N. H. FELDMAN; R. G. CUTLER; S. CAMANDOLA*; T. 

G. SON; N. H. GREIG; M. P. MATTSON. NIA. 

9:00 VV6 379.6 Heat-shock protein 90 regulates poly-a 

binding protein nuclear 1 aggregation and degradation. S. 

LUO*; D. ZHU; B. ZHANG; W. XIONG; L. MEI. Med. Coll 

Georgia, Nanchang Univ., Med. Col. of Georgia. 

10:00 VV7 379.7 • The effect of a soluble activin receptor 

type IIB on whole body tension in mdx mice is improved by 

co-administration of an NF-kappaB inhibitor. C. CARLSON*; 

L. MCCARTHY; K. BRUEMMER; J. SESTI; C. STEFANSKI; 

H. CURTIS; J. UCRAN. AT Still Univ., Acceleron Pharma. 

11:00 VV8 379.8 TrkB signaling represents a novel 

therapeutic target for neuromuscular diseases. S. G. 

DORSEY*; R. LOVERING; C. L. RENN; K. VOELKER; C. 

FRASER-LIGGETT; R. BALICE-GORDON; L. TESSAROLLO; 

C. W. WARD. Univ. of Maryland Baltimore, Virginia Tech., 

Univ. of Pennsylvania, Natl. Cancer Institute-Frederick. 

8:00 VV9 379.9 • Insulin-like growth factor 1 (IGF-1) 

stimulation and myostatin inhibition have synergistic effects 

on muscle mass and strength. P. JANGOUK*; Z. B. LI; E. R. 

BARTON; K. R. WAGNER. The Kennedy Krieger Institute, 

The Johns Hopkins Sch. of Med., Univ. of Pennsylvania. 

9:00 VV10 379.10 Lowering mechanisms of colonic motility in 

TNBS-induced experimental colitis. P. BYONG-GON*; Y. CUI; 

F. LI. Col. of Medicine, Kwandong Univ. 

10:00 VV11 379.11 Neurological influences and modulation 

of skeletal muscle tone. S. MANNAVA*; W. F. WIGGINS; M. 

F. CALLAHAN; J. STITZEL; L. A. KOMAN; C. J. TUOHY; T. 

L. SMITH. Wake Forest Univ. Dept. of Orthopaedic Surgery, 

Wake Forest Univ. Grad. Sch. of Arts and Sci. 

11:00 VV12 379.12 Mammalian muscle energetics model for 

predicting neural control strategies underlying movement. G. 

A. TSIANOS; C. RUSTIN; G. E. LOEB*. USC, Brussels-Mons 

Inst. of Engin. 



POSTER 

380. Basal Ganglia: Systems Behavior 



8:00 VV13 380.1 Proprioceptive processing and the role of 

right putamen in young and older adults. D. J. GOBLE*; J. P. 

COXON; A. VAN IMPE; N. WENDEROTH; S. P. SWINNEN. 

Univ. of Michigan, Katholieke Univ. Leuven. 

9:00 VV14 380.2 Reward and uncertainty encoding by 

local field potentials in the medial intraparietal sulcus. R. G. 

STACEY*; C. GROSS; G. TSOULFAS; S. MUSALLAM. McGill 

University, Montreal. 

10:00 VV15 380.3 Effects of repeated aripiprazole treatment 

on the amphetamine-induced locomotor activity and 

stereotypy of preweanling rats. T. DER-GHAZARIAN*; S. 

CHARNTIKOV; F. A. VARELA; S. A. MCDOUGALL. California 

State Univ. 

11:00 VV16 380.4 Self-generated trial-and-error learning for 

the initiation timing of both self-timed movements and simple 

reactions: A spiking network model of the basal ganglia. O. 

SHOUNO*; H. TSUJINO. Honda Res. Inst. Japan Co Ltd. 

8:00 VV17 380.5 Functional connectivity of the putamen 

in Tourette’s syndrome. I. NEUNER*; C. WERNER; T. 

KELLERMANN; J. BATH; T. STÖCKER; H. WEGENER; 

F. SCHNEIDER; N. SHAH. RWTH Aachen Univ., 

Forschungszentrum Juelich. 

9:00 VV18 380.6 Optogenetic dissection of basal ganglia 

circuit function in normal and parkinsonian mice. A. V. 

KRAVITZ*; B. FREEZE; P. PARKER; K. KAY; M. THWIN; K. 

DEISSEROTH; A. KREITZER. Gladstone Inst., Stanford Univ. 

10:00 VV19 380.7 Distinct roles of striatonigral and 

striatopallidal transmission in reward and aversive behavior. 

T. HIKIDA*; K. KIMURA; N. WADA; K. FUNABIKI; S. 

NAKANISHI. Osaka Biosci. Inst., JST, Kyoto Univ. Fac. of 

Med. 

11:00 VV20 380.8 Beta oscillations in cortical-basal ganglia 

circuits and the suppression of specific actions. G. GAGE*; A. 

B. WILTSCHKO; J. D. BERKE. Univ. of Michigan. 

8:00 WW1 380.9 Goal-direct motor sequence learning 

based on multiple basal ganglia-cortical loops. F. CHERSI*; M. 

MIROLLI; K. GURNEY; P. REDGRAVE; G. BALDASSARRE. 

CNR ISTC, Univ. of Sheffield. 

9:00 WW2 380.10 Investigating the role of striatal 

interneurons in the performance of action sequences using 

optogenetics. F. TECUAPETLA*; X. JIN; R. COSTA. Inst. 

Gulbenkian Ciencia, NIAAA/NIH,. 

10:00 WW3 380.11 On locomotion elicited by unilateral 

infusion of bicuculline into the basal forebrain of the rat. D. S. 

ZAHM*; C. W. GHOBADI; H. N. LAVEZZI; K. P. PARSLEY. St 

Louis Univ. Sch. of Med. 

11:00 WW4 380.12 Mapping the intrinsic structure of the 

caudate nucleus. A. ANWANDER*; T. R. KNÖSCHE; H. 

AXER; S. A. KOTZ. Max Planck Inst. For Human Cognitive 

and Brain Sci., Friedrich-Schiller-University Jena. 

8:00 WW5 380.13 Effects of D1 and D2 receptor stimulation 

in the dorsal caudate-putamen of preweanling rats: impact 

on locomotor activity and stereotypy. M. S. HERBERT*; S. 

CHARNTIKOV; T. DER-GHAZARIAN; L. R. HORN; C. B. 

WIDARMA; S. A. MCDOUGALL. California State Univ. 


Mon. AM

9:00 WW6 380.14 Paradoxical behavioral effects of 

DA receptor inactivation in young rats: role of the dorsal 

caudate-putamen. T. DER-GHAZARIAN; L. R. HORN; 

M. S. HERBERT; A. GUTIERREZ; C. B. WIDARMA; S. 

CHARNTIKOV; S. A. MCDOUGALL*. California State 

Univiversity. 

10:00 WW7 380.15 CalDAG-GEFI is required for normal 

striatum-based egocentric maze learning in mice and the 

balance between cholinergic and dopaminergic signaling 

in the striatum. J. R. CRITTENDEN*; M. SAUVAGE; E. 

BURGUIERE; M. J. YIM; C. COSTA; G. MARTELLA; V. 

GHIGLIERI; H. ZHANG; K. A. PESCATORE; T. LIU; E. M. 

UNTERWALD; B. PICCONI; D. SULZER; P. CALABRESI; A. 

M. GRAYBIEL. MIT, Ruhr Univ. Bochum, Fondazione Santa 

Lucia IRCCS, Columbia Univ., Temple Univ. Sch. of Med., 

Clinica Neurologica, Univ. degli Studi di Perugia. 

11:00 WW8 380.16 Using medial forebrain bundle stimulation 

to reinforce spatial-temporal patterns of neuron firing rate in 

the frontal cortex. N. A. BALDWIN*; R. J. BRACKNEY; S. I. 

HELMS TILLERY. Arizona State Univ. 

8:00 WW9 380.17 Characterising effects of decision context 

on basal ganglia responses using fMRI: An anatomicallydriven 

region of interest approach. S. M. FLEMING*; C. 

LAMBERT; J. ASHBURNER; R. J. DOLAN. Univ. Col. London. 

9:00 WW10 380.18 The effect of age on cortico-basal 

ganglia circuit function during motor task execution. W. R. 

MARCHAND*; J. N. LEE; C. GARN; S. S. JOHNSON; N. 

WOOD; G. CHELUNE; Y. SUCHY. Univ. Utah, George E 

Wahlen VAMC. 

10:00 WW11 380.19 Input dependent cell assembly dynamics 

in an inhibitory spiking network model. A. P. PONZI*; J. 

WICKENS. OIST. 

POSTER 

381. Posture and Gait: Muscle Activity and fatigue 



8:00 WW12 381.1 Impact of neuromuscular fatigue on 

postural strategy selection. A. C. KENNEDY*; A. GUÉVEL; G. 

ROBERTSON; S. HEIDI. Univ. of Ottawa, Univ. of Nantes. 

9:00 WW13 381.2 Is wide stance stabilizing? Predictions of 

postural stability and stepping threshold from a frontal-plane 

delayed feedback model. J. BINGHAM*; J. T. CHOI; L. H. 

TING. Georgia Inst. of Technol., Emory Univ. 

10:00 WW14 381.3 Stability and flexibility trade-offs in 

standing balance control at different stance widths. J. T. CHOI; 

J. T. BINGHAM; L. H. TING*. Emory Univ. Georgia Tech., 

Georgia Inst. of Technol. 

11:00 WW15 381.4 Determination of neuromuscular fatigue 

in basketball players using recurrence quantification analysis 

of surface emg. S. UZUN*; A. POURMOGHADDAM; M. 

HIERONYMUS; S. MATHEW; A. THRASHER. Marmara Univ., 

Univ. of Houston. 

8:00 WW16 381.5 Trunk muscles respond to task specific 

fatigue in an opposite manner as appendicular muscles. J. S. 

THOMAS*; R. ROSS; D. W. RUSS; B. C. CLARK; J. COWEN; 

R. PICKETT; M. LINSENMAYER. Ohio Univ., Ohio Univ. Col. 

of Osteo. Med. 

9:00 WW17 381.6 Attentional demands associated with 

postural control depend on the difficulty of the postural task. A. 

REMAUD*; G. CARON; S. BOYAS; M. BILODEAU. Élisabeth 

Bruyère Res. Inst., Univ. of Ottawa. 

10:00 WW18 381.7 Impairment in postural control is 

greater when ankle plantar and dorsal flexors are fatigued 

simultaneously than separately. S. BOYAS*; S. CADIEUX; B. 

MOREL; A. REMAUD; E. BISSON; M. BILODEAU. Univ. of 

Ottawa, Élisabeth Bruyère Res. Inst., Univ. of OTTAWA. 

11:00 WW19 381.8 • Functional compartments in the human 

splenius capitis muscle are revealed by constrained 

isometric tasks. A. VASAVADA; J. BLOUIN; R. NEWELL; 

G. P. SIEGMUND*. Washington State Univ., Univ. of British 

Columbia, MEA Forensic Engineers & Scientists. 

8:00 WW20 381.9 Smudging of the motor cortex 

representation of the paraspinal muscles in low back pain. P. 

W. HODGES*; H. TSAO; L. DANNEELS. Univ. Queensland, 

Univ. of Gent. 

9:00 XX1 381.10 Contingent negative variation and 

activation of postural muscles before postural perturbation by 

backward floor translation at different initial standing positions. 

K. FUJIWARA*; N. KIYOTA. Kanazawa Univ. 

10:00 XX2 381.11 Changes in postural sway and attentional 

demands in older healthy adults due to ankle muscle 

fatigue. E. J. BISSON*; C. CHAVARIE; K. KAVANAUGH; M. 

LORANGER; M. TAKATSUKA; M. BILODEAU. Univ. Ottawa, 

Élisabeth Bruyère Res. Inst., Univ. of Ottawa. 

11:00 XX3 381.12 Recruitment of muscle synergies by 

center-of-mass feedback throughout postural perturbations. 

S. A. SAFAVYNIA*; L. H. TING. Emory Univ., Emory Univ. and 

Georgia Tech. 

8:00 XX4 381.13 Optimal control of muscle synergies but 

not individual muscles reproduces ground reaction forces 

during cat postural control in different postural configurations. 

J. MCKAY*; L. H. TING. Georgia Inst. of Technol., Emory Univ. 

and Georgia Tech. 

9:00 XX5 381.14 Muscle fatigue effects on sway and 

attentional demands during a challenging postural task. M. 

NOVIKOV; M. BILODEAU*. Univ. of Ottawa, Univ. Ottawa, 

Élisabeth Bruyère Res. Inst. 

10:00 XX6 381.15 Anticipatory postural adjustments during 

multidirectional reactive and voluntary steps depend on 

mechanical task demands. S. A. CHVATAL*; L. H. TING. 

Biomed. Engineering, Emory Univ. and Georgia Tech. 

11:00 XX7 381.16 Muscular responses evoked by 

mechanically dorsoflexion of the ankle during running in 

man. M. SCOHIER; D. DEJAEGER; B. SCHEPENS*. Univ. 

catholique Louvain. 

8:00 XX8 381.17 • Decreased postural compensation for 

respiratory perturbation during inspiratory muscles fatigue 

in individuals with and without recurrent low back pain. L. 

JANSSENS*; M. PIJNENBURG; S. BRUMAGNE. Fac. of 

Rehabil. Sci. and Kinesiology (katholieke Univ. Leuv, Dept. of 

Rehabil. Sci. and Kinesiology, Univ. of Leuven. 

9:00 XX9 381.18 Time-dependent changes in postural sway 

dynamics due to fatigue. K. S. THOMAS*; S. MORRISON; B. 

L. VAN LUNEN. Old Dominion Unversity. 

10:00 XX10 381.19 Construction of a musculoskeletal model 

of the cat forelimb. R. MARTIN*; C. TAN; T. J. BURKHOLDER; 

T. R. NICHOLS. Georgia Inst. of Technol. 



11:00 XX11 381.20 Activation patterns of postural muscles 

during bilateral arm flexion in childhood. T. KIYOTA*; 

K. FUJIWARA; K. KUNITA; M. IREI; K. ANAN. Fac. of 

Humanities, Sapporo Intl. Univ., Grad. Sch. of Med. Science, 

Kanazawa Univ., Fac. of Sports & Human, Sapporo Intl. Univ. 

8:00 XX12 381.21 Direction-dependent muscle synergies 

for the reactive recovery of balance following perturbations 

during gait. A. S. OLIVEIRA*; U. G. KERSTING; L. GIZZI; D. 

FARINA. Aalborg Univ., The Capes Fndn. 

9:00 XX13 381.22 Neuromuscular response to stumbling in 

healthy subjects and patients with transfemoral amputations. 

F. ZHANG; A. BURKE; F. SIERRA; S. D’ANDREA; M. 

NUNNERY; H. HUANG*. Univ. of Rhode Island, Providence 

VA Med. Ctr., Brown Univ., Nunnery Orthotics and Prosthetics 

Technologies. 

10:00 XX14 381.23 Neural compensation for partial synergist 

denervation. K. S. HART; P. NARDELLI*; T. C. COPE. Wright 

State University-Swets. 

11:00 XX15 381.24 � The influence of muscles, fascia and 

adipose tissue on limb and joint variables during locomotion. 

M. I. FALCON*; V. A. STAHL; T. R. NICHOLS. Georgia Inst. of 

Technol. 

8:00 XX16 381.25 Joint angle-dependent modulation of 

plateau-like behavior in human motoneurons. A. FRIGON; 

C. K. THOMPSON; C. HECKMAN*; T. G. HORNBY. 

Northwestern Univ., Univ. of Illinois at Chicago, Northwestern 

Univ. Med. Sch. 

POSTER 

382. Cortical Interactions for Voluntary Movement Control 



8:00 XX17 382.1 Falling activity as a motor timing signals 

within area LIP during a rhythmic saccade task. B. A. 

SCHNEIDER*; G. M. GHOSE. Univ. of Minnesota. 

9:00 XX18 382.2 Some basic features of the 

neural response in motor and premotor cortex. M. M. 

CHURCHLAND*; M. T. KAUFMAN; J. P. CUNNINGHAM; S. I. 

RYU; K. V. SHENOY. Stanford Univ., Univ. of Cambridge. 

10:00 XX19 382.3 Neuronal activity of the dorsal premotor 

area (PMd) and the primary motor area (MI) of macaques in 

the process of motor selection based on the virtual action plan 

made in a voluntary fashion. M. HASHIMOTO*; Y. SAGA; L. 

TREMBLAY; J. TANJI; E. HOSHI. Tamagawa Univ. Brain Sci. 

Inst., CNRS. 

11:00 XX20 382.4 Neuronal activity in the medial motor 

areas reflects the switching of arm use and switching of action 

during performance of a bimanual sequential motor task. T. 

NAKAJIMA*; R. HOSAKA; J. TANJI; H. MUSHIAKE. Tohoku 

Univ. Sch. Med., Fukuoka Univ. 

8:00 YY1 382.5 Modulation of LFP beta oscillation while 

updating motor plan in primate medial motor areas. R. 

HOSAKA*; T. NAKAJIMA; K. AIHARA; Y. YAMAGUCHI; H. 

MUSHIAKE. Fukuoka Univ., RIKEN Brain Sci. Inst., Japan 

Sci. and Technol. agency, Tohoku university school of 

medicine, The university of Tokyo. 

9:00 YY2 382.6 Nonlinear dynamics of reciprocity between 

motor cortex and cerebellar nucleus. G. DAM*; W. JUN; J. C. 

HOUK. Northwestern Univ., Syracuse Univ. 



10:00 YY3 382.7 The role of the supplementary motor area 

in the control of intracortical and interhemispheric inhibition of 

the primary motor cortex. S. A. SHARPLES; Q. J. ALMEIDA; 

J. M. KALMAR*. Wilfrid Laurier Univ. 

11:00 YY4 382.8 Analysis of mutual information in primary 

motor and dorsal premotor neurons. G. PELLIZZER*; B. 

AMIRIKIAN; S. DANI. VA Med. Ctr., Univ. of Minnesota. 

8:00 YY5 382.9 Time encoding in dorsolateral prefrontal 

cortex in the non human primate. S. KERRIGAN*; J. ASHE; B. 

AMIRIKIAN. Univ. of Minnesota, VAMC. 

9:00 YY6 382.10 Dynamic interactions of motor cortical 

neurons during a learning control task using an approximate 

inhomogeneous Poisson process model. C. YANG*; J. SI. 


10:00 YY7 382.11 • Neural adaptation during learning a 

directional paddle press task in rat’s premotor and primary 

motor cortices. H. MAO*; J. SI. Arizona State Univ. 

11:00 YY8 382.12 Neural encoding in the motor cortical 

areas associated with cognitive learning control. Y. YUAN*; J. 

SI. Arizona State Univ. 

8:00 YY9 382.13 Single-unit activity in macaque dorsal 

premotor cortex during obstacle-avoidance vs. direct reaching 

movements. T. M. PEARCE*; D. W. MORAN. Washington 

Univ. 

9:00 YY10 382.14 Evidence for a directionally alternating, 

gamma-band ‘dialog’ binding olfactory-motor information 

during a GO/NO-GO reaching task. L. L. HERMER*; M. DING. 

Univ. Florida. 

POSTER 

383. BMI: Recording Methods and Information Processing 



8:00 ZZ1 383.1 The influence of cortical blood vessels 

on ECoG signals. M. BLEICHNER*; M. VANSTEENSEL; A. 

TORRES VALDERRAMA; D. HERMES; C. H. FERRIER; N. F. 

RAMSEY. Rudolf Magnus Inst. of Neurosci. 

9:00 ZZ2 383.2 Neural correlates of directional attention 

in electrocorticographic (ECoG) signals in humans. 

A. GUNDUZ*; P. BRUNNER; A. RITACCHIO; E. C. 

LEUTHARDT; B. PESARAN; G. SCHALK. Wadsworth Ctr., 

Albany Med. Col., Graz Univ. of Tech., Washington Univ., New 

York Univ., State Univ. of New York, Rensselaer Polytechnic 

Inst. 

10:00 ZZ3 383.3 Quantitative comparison of ECoG 

mu/beta and gamma activity during actual and imagined 

word repetition. X. PEI*; P. BRUNNER; M. SHARMA; 

Z. FREUDENBURG; E. C. LEUTHARDT; G. SCHALK. 

Wadsworth Ctr, NYSDOH, Washington Univ., Albany Med. 

Col., Rensselaer Polytechnic Inst., State Univ. of New York. 

11:00 ZZ4 383.4 Decoding spatial attention using 

electrocorticographic (ECoG) signals in humans. G. 

SCHALK*; P. BRUNNER; A. RITACCHIO; E. C. LEUTHARDT; 

B. PESARAN; A. GUNDUZ. Wadsworth Ctr, NYSDOH, Albany 

Med. Col., Washington Univ., Rensselaer Polytechnic Inst., 

State Univ. of New York, Graz Univ. of Tech., New York Univ. 

8:00 ZZ5 383.5 Comparison of activity and connectivity 

metrics for decoding behavioral characteristics and social 

states in macaques. K. TAKENAKA*; T. YANAGAWA; Y. 

NAGASAKA; Z. C. CHAO; Y. KUNIYOSHI; N. FUJII. The Univ. 

of Tokyo, Res. Fellow of JSPS, RIKEN, BSI. 


Mon. AM

9:00 ZZ6 383.6 Novel method to describe neural dynamics 

across brain regions. T. YANAGAWA*; Y. NAGASAKA; N. 

FUJII. RIKEN. 

10:00 ZZ7 383.7 Temporal dynamics of high-frequency 

(>75Hz) power increase in electrocorticographic brain 

signals during cue-guided movement of individual digits. 

R. SCHERER; F. DARVAS*; S. ZANOS; K. MILLER; L. 

SORENSEN; A. HEBB; R. P. N. RAO; J. OJEMANN. Univ. 

Washington. 

11:00 ZZ8 383.8 Electrocorticographical changes 

during training on brain-computer interfaces. T. BLAKELY; 

K. J. MILLER; R. P. N. RAO; J. G. OJEMANN*. Univ. of 

Washington. 

8:00 ZZ9 383.9 � Decoding self-timed motor behavior with 

hidden Markov models. Z. HAN*; Z. LI; J. O’DOHERTY; M. 

LEBEDEV; M. NICOLELIS. Duke Univ., Edmond and Lily 

Safra Intl. Inst. of Neurosci. of Natal. 

9:00 ZZ10 383.10 Closed-loop adaptive decoding using 

bayesian regression self-training. Z. LI*; J. E. O’DOHERTY; 

M. A. LEBEDEV; M. A. L. NICOLELIS. Duke Univ., Edmond 

and Lily Safra Intl. Inst. of Neurosci. 

10:00 AAA1 383.11 Extraction of EMGs from cortical ensemble 

activity during a motor timing task. K. Z. ZHUANG*; J. E. 

O’DOHERTY; M. A. LEBEDEV; M. A. L. NICOLELIS. Duke 

Univ., Edmond and Lily Safra Intl. Inst. of Neurosci. 

11:00 AAA2 383.12 Integration of a virtual reality based 

arm in primary somatosensory cortex. S. SHOKUR*; J. 

E. O’DOHERTY; M. A. LEBEDEV; H. BLEULER; M. A. L. 

NICOLELIS. Duke Univ., EPFL, Edmond and Lily Safra Intl. 

Inst. of Neurosci. of Natal. 

8:00 AAA3 383.13 The role of corticostriatal dynamics 

in learning to operate a brain-machine interface. A. C. 

KORALEK*; X. JIN; J. D. LONG, II; R. M. COSTA; J. 

M. CARMENA. Helen Wills Neurosci. Institute, Univ. of 

California, Berkeley, Lab. for Integrative Neuroscience, Natl. 

Inst. on Alcohol Abuse and Alcoholism, Natl. Inst. of Hlth., 

Champalimaud Neurosci. Programme at Inst. Gulbenkian de 

Ciência, Rua da Quinta Grande, Dept. of Electrical Engin. and 

Computer Sci., Program in Cognitive Sci. 

9:00 AAA4 383.14 A computational model for simulating 

recruitment of peripheral nerve fibers by intraneural 

microstimulation. D. J. BOURBEAU*; J. A. HOKANSON; J. E. 

RUBIN; G. B. ERMENTROUT; D. J. WEBER. Univ. Pittsburgh. 

10:00 AAA5 383.15 Using reward to change population tuning 

to improve decode performance for use in neural prosthetic 

systems. C. WHARIN*; S. MUSALLAM. McGill Univ. 

11:00 AAA6 383.16 Decoding motor outputs with epidural and 

intracortical inputs: Performance similarities and differences. 

M. W. SLUTZKY*; E. LINDBERG; L. R. JORDAN; L. E. 

MILLER. Northwestern Univ. 

8:00 AAA7 383.17 Withdrawn 

9:00 AAA8 383.18 Human neurodynamics of volitional 

movement through high resolution electrocorticography. A. 

TORRES VALDERRAMA*; N. RAMSEY; M. VANSTEENSEL; 

E. AARNOUTSE. Rudolf Magnus Institute, Univ. of Utrecht, 

Dept Neurol. and Neurosurg. 

10:00 AAA9 383.19 Decoding individual finger movement 

using surface subdural recordings. C. G. REDDY*; G. G. 

REDDY; H. KAWASAKI; H. OYA; L. MILLER; M. A. HOWARD, 

III. Univ. of Iowa, Northwestern Univ. 

11:00 AAA10 383.20 Decoding continuous 3D hand trajectories 

from epidural electrocorticography in Japanese macaque. K. 

SHIMODA*; Z. C. CHAO; Y. NAGASAKA; N. FUJII. RIKEN 

Brain Sci. Inst., Nihon Univ. Sch. of Med. 

8:00 AAA11 383.21 Optimizing information transfer in neural 

prosthetic systems by using multimodal signals and rapid 

plasticity. C. GROSS*; G. TSOULFAS; M. HAJJ-HASSAN; V. 

CHODAVARAPU; S. MUSALLAM. McGill Univ. 

9:00 AAA12 383.22 Muscle-like neurons for a muscle-like BMI: 

No evidence for extrinsic neurons in M1. E. R. OBY*; R. F. 

FRIESEN; L. E. MILLER. Northwestern Univ. 

10:00 AAA13 383.23 Influence of brain state on spatial extent 

and frequency of local field potentials in human and cat 

neocortex. S. J. HANRAHAN*; T. S. DAVIS; R. A. PARKER; K. 

E. THOMSON; B. GREGER; P. A. HOUSE. Univ. of Utah. 

11:00 AAA14 383.24 A study of how to optimally transfer 

information between stimulating and recording electrodes 

in a closed loop brain machine interface. M. SEMPRINI*; 

F. SZYMANSKI; E. MAGGIOLINI; F. A. MUSSA-IVALDI; L. 

FADIGA; S. PANZERI; A. VATO. Italian Inst. of Technol., Univ. 

of Genoa, Northwestern Univ., Rehabil. Inst. of Chicago, Univ. 

of Ferrara. 

8:00 AAA15 383.25 Dynamic shaping: A new paradigm 

for bidirectional brain-machine interfaces. A. VATO*; M. 

SEMPRINI; E. MAGGIOLINI; L. FADIGA; S. PANZERI; F. A. 

MUSSA-IVALDI. Italian Inst. of Technol., Univ. of Genoa, Univ. 

of Ferrara, Northwestern Univ., Rehabil. Inst. of Chicago. 

9:00 AAA16 383.26 Operant conditioning to identify volitionally 

controllable patterns of neural activity. S. M. CHASE*; A. S. 

WHITFORD; R. E. KASS; A. B. SCHWARTZ. Univ. Pittsburgh, 


10:00 AAA17 383.27 Coordination and control of cortical activity 

patterns identified via operant conditioning. A. S. WHITFORD; 

S. M. CHASE; A. B. SCHWARTZ*. Univ. of Pittsburgh, Ctr. 

for the Neural Basis of Cognition, Univ. Pittsburgh, Carnegie 

Mellon Univ. 

11:00 AAA18 383.28 Polystyrene casts of neuron basal lamina 

for guidance of axons. M. KARLSSON; F. JOHANSSON; M. 

E. KANJE*. Biol., Cell and Organism Biol. 

POSTER 

384. hPA Axis: Steroid Control 

Theme E: Homeostatic and Neuroendocrine Systems 


8:00 AAA19 384.1 Does a single exposure to stress 

affect long-term negative feedback mechanisms of the 

hypothalamic-pituitary-adrenal axis in rats? X. BELDA; A. 

ARMARIO*. Unidad Fisiol Animal, Biocienc. 

9:00 AAA20 384.2 Chronic, non-invasive corticosterone 

delivery disrupts the circadian pattern of hypothalamicpituitary-adrenal 

(HPA) axis activity and induces anxiety- and 

depression-like behaviors in rats. N. C. DONNER*; C. D. 

MONTOYA; A. J. WACKER; C. A. LOWRY. Univ. of Colorado. 

10:00 AAA21 384.3 Fetal exposure to synthetic glucocorticoids 

has transgenerational effects on regulation of central 

glucocorticoid feedback. V. MOISIADIS*; A. KOSTAKI; S. G. 

MATTHEWS. Univ. of Toronto. 



11:00 AAA22 384.4 • Effects on corticosterone levels of rats 

exposed to differences times of restraint and submitted to 

ETM. N. L. GARCIA SALDIVAR*; M. R. A. GONZÁLEZ- 

LÓPEZ; G. CASTILLO-ROBERTO; R. DOMÍNGUEZ; S. 

E. CRUZ-MORALES. UNAM FES-Iztacala, FES Zaragoza 

UNAM. 

8:00 BBB1 384.5 BDNF and glucocorticoid signaling 

crosstalk in the HPA axis. F. JEANNETEAU*; M. LAMBERT; 

K. BATH; T. NEUBERT; F. S. LEE; M. GARABEDIAN; M. V. 

CHAO. Skirball Inst. of Biomolecular Med., New York Univ., 

Weill Cornell Med. Col. 

9:00 BBB2 384.6 Androgens modulate the reactivity of 

the HPA axis in male and female rhesus monkeys. D. J. 

TOUFEXIS*; M. E. WILSON. Univ. of Vermont, Yerkes Natl. 

Primate Res. Center, Emory Univ. 

10:00 BBB3 384.7 Gender differences in autonomic, 

neuroendocrine, and behavioral responses to unpredictable 

environmental stressors are altered by stress-targeted 

interventions. J. VANDERSLICE-BAR*; J. J. PARIS; C. A. 

FRYE. Univ. Albany. 

11:00 BBB4 384.8 Effects of environmental stress and 

enrichment on autonomic, neuroendocrine, and depressionlike 

status among male and female rats and mice. K. L. 

EDINGER*; A. K. KOHTZ; D. M. OSBORNE; D. C. LLANEZA; 

D. J. DACOSTA; C. J. KOONCE; J. J. PARIS; A. A. WALF; C. 

A. FRYE. Univ. Albany, Univ. at Albany. 

8:00 BBB5 384.9 Estrogen receptor beta is involved in 

estradiol’s modulation of depressive-like behavior and stress 

responses of adult mice. A. A. WALF*; C. A. FRYE. Univ. At 

Albany, Univ. at Albany. 

9:00 BBB6 384.10 Differences in cyclin D1 expression may 

underlie trophic effects in the hippocampus, mammary tumors, 

and uteri of rats treated with selective estrogen receptor 

modulators. J. RUSCONI*; A. A. WALF; C. A. FRYE. Taconic, 

Inc, Univ. at Albany. 

10:00 BBB7 384.11 • Role of prolactin in HPA axis activation 

following acute stress in mice. S. NAYAR*; E. MURPHREE; J. 

JANIK; P. CALLAHAN. Miami Univ. 

11:00 BBB8 384.12 • Effect of pup separation on HPA axis 

activation and PRL-R mRNA levels in the choroid plexus 

following stress in postpartum female rats. M. KALYANI; M. 

BECK; S. LAHEY; E. MURPHREE; P. A. CALLAHAN*; J. 

JANIK. Miami Univ. 

8:00 BBB9 384.13 • Estrogen affects the Nociceptin/Orphanin 

FQ (N/OFQ)-mediated neuroendocrine response to stress. 

M. SESHADRI*; T. HURST; K. MCEWEN; E. MURPHREE; P. 

CALLAHAN; J. JANIK. Miami Univ. 

9:00 BBB10 384.14 • Effects of restrain or the exposure 

to elevated T maze (ETM) on monoaminergic systems in 

lateral prefrontal cortex (PFC) and dorsal striatum (DS) 

in ovariectomized rats. M. R. GONZALEZ LOPEZ*; N. 

L. GARCÍA-SALDÍVAR; G. CASTILLO-ROBERTO; R. 

DOMÍNGUEZ; J. MONROY-MORENO; S. CRUZ-MORALES. 

UNAM FES-Iztacala, UNAM FES-Zaragoza. 

10:00 BBB11 384.15 Sexually dimorphic effects of gonadal 

hormones on hypothalamic-pituitary-adrenal axis activation 

induced by alcohol in rats. S. L. BINKS; J. W. LARKIN; D. 

SELVAGE*. Idaho State Univ. 



POSTER 

385. Steroids and Plasticity: Development and Sex Differences 



8:00 BBB12 385.1 Ovarian hormones increase dendritic 

spine-dependent RhoA expression in the serotonergic dorsal 

raphe nucleus. H. M. RIVERA*; C. L. BETHEA. Oregon Hlth. 

& Sci. University/ONPRC Div. of Reproductive Sci. 

9:00 BBB13 385.2 Relaying function of the STB/HAP1 on 

nuclear translocation of androgen and glucocorticoid receptors 

and its proteasome-dependent regulation. R. FUJINAGA*; Y. 

TAKESHITA; K. YOSHIOKA; H. NAKAMURA; S. SHINODA; 

A. YANAI; K. KOKUBU; K. SHINODA. Div. of Neuroanatomy, 

Yamaguchi Univ. Sch. of Med. 

10:00 BBB14 385.3 SUMOylation of estrogen receptor beta 

(ERβ) in neurons: The consequences of 17β-Estradiol. N. 

MOTT*; T. PAK. Loyola Univ. Chicago. 

11:00 BBB15 385.4 Estrgoen regulation of mirna expression 

in neurons. Y. S. RAO*; T. R. PAK. Stritch Sch. of Medicine, 

Loyola Univ. Chicago. 

8:00 BBB16 385.5 The distribution of membrane 

progesterone receptors alpha and beta in the female rat brain. 

D. G. ZULOAGA*; P. THOMAS; R. J. HANDA; S. K. MANI. 

Univ. of Arizona Col. of Medicine-Phoenix, Univ. of Texas at 

Austin, Baylor Col. of Med. 

9:00 BBB17 385.6 Imaging brain aromatase using [11C] 

cetrozole and its analogs. K. TAKAHASHI*; T. HOSOYA; K. 

ONOE; H. DOI; H. NAGATA; Y. WATANABE; Y. WADA; T. 

TAKASHIMA; Y. KATAYAMA; H. YAMANAKA; M. SUZUKI; H. 

ONOE; Y. WATANABE. RIKEN, Ctr. For Mol. Imaging Sci., 

Tokyo Med. and Dent. Univ. 

10:00 BBB18 385.7 Sex differences in the ability of 

testosterone to induce increases in the volume of the song 

control nucleus HVC in canaries. F. N. MADISON*; M. L. 

ROUSE, Jr.; J. BALTHAZART; G. F. BALL. Johns Hopkins 

Univ., Univ. of Liege. 

11:00 BBB19 385.8 Trophic effects of brain-derived 

neurotrophic factor blockade in a sexually dimorphic 

neuromuscular system. T. VERHOVSHEK*; D. R. 

SENGELAUB. Indiana Univ. 

8:00 BBB20 385.9 Transient expression of estrogen receptor 

in target musculature coincides with estrogenic support 

of motoneuron dendrite growth. L. M. RUDOLPH*; D. R. 

SENGELAUB. Indiana Univ. 

9:00 BBB21 385.10 Local application of testosterone at the 

target musculature regulates brain-derived neurotrophic 

factor in spinal motoneurons. T. VERHOVSHEK; D. R. 

SENGELAUB*. Indiana Univ. 

10:00 BBB22 385.11 Structural reorganization of the medial 

amygdala during puberty. B. M. COOKE*. Georgia State Univ. 

11:00 CCC1 385.12 Adult circulating androgens maintain 

lateralized sex differences in astrocyte number and complexity 

in the rat amygdala. R. T. JOHNSON*; S. M. BREEDLOVE; C. 

L. JORDAN. Michigan State Univ. 

8:00 CCC2 385.13 Normal volumetric human brain 

parameters and asymmetry indexes: Quantitative evidence 

from in vivo 3.0T MR imaging in Mexican-mestizo volunteers. 

E. ROLDAN-VALADEZ; M. A. SUAREZ-MAY; E. AGUILAR- 

CASTAÑEDA; A. DIAZ-RUIZ; F. SOLIS-HERNANDEZ; C. 

RIOS*. Hosp. Medica Sur, Natl. Inst. Neurology, Neurosurg. 


Mon. AM

9:00 CCC3 385.14 Induced alterations of pubertal 

development modulates brain structure in mice. S. SPRING*; 

C. ALM; L. CAHILL; M. ERIC-SOUSSI; M. R. PALMERT; J. 

P. LERCH. Hosp. For Sick Children, Hosp. for Sick Children; 


POSTER 

386. Sexual Differentiation 



8:00 CCC4 386.1 Expression of immunoglobulin superfamily, 

member 1 (IGSF1/InhBP/p120) isoforms in the adult murine 

pituitary and brain. B. BAK*; X. ZHOU; D. BERNARD. McGill 

Univ. 

9:00 CCC5 386.2 Hypothalamic expression of snorna 

SNORD116 implies its contribution to the pathogenesis 

of Prader-Willi syndrome. Q. ZHANG; G. J. BOUMA; K. 

MCCLELLAN*; S. TOBET. Colorado State Univ., Buena Vista 

Univ. 

10:00 CCC6 386.3 Estradiol induced masculinization of the 

preoptic area: downstream effects on prostaglandin synthesis 

and AMPA receptor phosphorylation. K. M. LENZ*; M. M. 

MCCARTHY. Univ. of Maryland Sch. of Med. 

11:00 CCC7 386.4 • Sex differences in Foxp2 expression in the 

developing rat brain. M. BOWERS*; M. M. MCCARTHY. Univ. 

of Maryland, Baltimore. 

8:00 CCC8 386.5 Microarray analysis following dnmt 

inhibition in the male and female preoptic area. B. M. 

NUGENT*; M. M. MCCARTHY. Univ. of Maryland, Sch. of 

Med. 

9:00 CCC9 386.6 Synaptic proteins are dimorphic and 

modified along the estrus cycle in the medial posterodorsal 

amygdala of rats. J. BRUSCO*; D. L. G. GITAÍ; M. L. PAÇÓ- 

LARSON; A. A. RASIA-FILHO; J. E. MOREIRA. Ribeirão 

Preto Sch. Med., Univ. of São Paulo, Alagoas Federal Univ., 

Ribeirão Preto Sch. of Med., Federal Univ. of Hlth. Sci. 

10:00 CCC10 386.7 Effect of perinatal HDAC inhibitor 

administration on sexually dimorphic cell death in the BNST. 

E. K. MURRAY*; C. J. SMITH; A. HIEN; M. M. VARNUM; G. J. 

DE VRIES; N. G. FORGER. Univ. Massachusetts, Amherst. 

11:00 CCC11 386.8 Sex hormonal effects, but not direct sex 

chromosomal effects, organize the number of vasopressinexpressing 

cells in the bed nucleus of the stria terminalis. 

B. D. ROOD*; E. HOLADAY; G. J. DE VRIES. Univ. 

Massachusetts, Amherst Col. 

8:00 CCC12 386.9 MeCP2 in the developing amygdala 

organizes sex differences in juvenile social behavior and 

vasopressin expression. R. M. FORBES-LORMAN*; K. M. 

KROL; J. R. KURIAN; A. P. AUGER. UW-Madison. 

9:00 CCC13 386.10 Simulating maternal grooming influences 

sexual differentiation of juvenile social play behavior. M. 

EDELMANN*; K. M. OLESEN; A. P. AUGER. Univ. of 

Wisconsin - Madison, Univ. of Massachusetts. 

10:00 CCC14 386.11 Interactions of sex and maternal care on 

NCoR and DISC1 mRNA levels within the developing brain. 

H. M. JESSEN*; M. N. EDELMANN; H. J. WHITE; D. C. 

GOODING; A. P. AUGER. Univ. Wisconsin Madison. 

11:00 CCC15 386.12 Full masculinization of the VMH is 

dependent on AR and circulating androgens in mice. J. L. 

SCHNUPP*; C. CHEN; C. L. JORDAN; S. M. BREEDLOVE. 

Michigan State Univ. 

8:00 CCC16 386.13 Mechanisms underlying the sex difference 

in long-term potentiation in the rat lateral amygdala. F. WU*; 

D. CHOU. Natl. Cheng Kung Univ. Col. Med. 

9:00 CCC17 386.14 Estrogen receptors in the cochlea of 

newborn, pre-pubertal, young adult, aged and ovariectomized 

mice. K. CHARITIDI; R. D. FRISINA*; O. N. VASILYEVA; X. 

ZHU; B. CANLON. Karolinska Institutet, Univ. of Rochester. 

10:00 CCC18 386.15 Androgen-sensitive anxiety-related 

behaviors affected by time of day and test order. C. CHEN*; J. 

S. LONSTEIN; C. L. JORDAN; S. M. BREEDLOVE. Michigan 

State Univ. 

11:00 CCC19 386.16 Sex-dependent modification of shared 

neural circuitry regulates multiple aspects of C. elegans 

behavior. D. S. PORTMAN*; R. MILLER; W. MOWREY; K. 

LEE. Univ. of Rochester. 

8:00 CCC20 386.17 Intracranial injections of fadrozole 

decrease neuron soma size within song control regions of the 

zebra finch. S. L. VENEY*; A. T. BENDER. Kent State Univ. 

9:00 CCC21 386.18 Sexually differentiated cell proliferation in 

the medial preoptic nucleus of Japanese quail. K. MOURIEC*; 

S. BARDET; J. BALTHAZART. Univ. of Liège, Univ. of 

Limoges. 

10:00 CCC22 386.19 Effects of indomethacin on the 

development of the song system in zebra finches. T. B. 

BOROWSKI*; M. L. RUIZ; M. FONG; X. CUI; W. GRISHAM. 

Pitzer Col., Harvey Mudd Col., UCLA. 

11:00 DDD1 386.20 Corticotropin-releasing factoroverexpressing 

(CRF-OE) mice display sex differences in 

weights of adrenal gland and brown fat, blood glucose and 

cytokines in perigonadal fat. L. WANG*; P. YUAN; C. KIANK; 

M. GOEBEL; A. STENGEL; Y. TACHÉ. UCLA. 

8:00 DDD2 386.21 • Effect of estrogen administration on 

insulin receptor function in long term high fat-fed male and 

female rats. W. PRATCHAYASAKUL*; S. KERDPHOO; N. 

CHATTIPAKORN; S. CHATTIPAKORN. Chiang Mai Univ. 

POSTER 

387. Social Behavior: Neuropeptides 



8:00 DDD3 387.1 Unsuspected distribution of urocortinergic 

neurons at the subgriseal perioculomotor region of a new 

world primate: The Callithrix jacchus. C. A. TOLEDO*; R. B. 

NASCIMENTO; J. S. CAVALCANTE. Univ. Cidade de Sao 

Paulo - UNICID, Federal Univ. of Rio Grande do Norte. 

9:00 DDD4 387.2 Where does monogamy reside in the 

brain? A functional imaging study of pair-bonding in the titi 

monkey (Callicebus cupreus). N. MANINGER; K. HINDE; S. 

P. MENDOZA; W. A. MASON; S. R. CHERRY; K. L. BALES*. 

California Natl. Primate Res. Ctr., Univ. of California, Univ. 

Calif. 

10:00 DDD5 387.3 Species differences in brain μ-opioid 

receptor distribution in monogamous prairie voles and 

polygamous meadow voles. K. INOUE*; J. P. BURKETT; L. J. 

YOUNG. Emory Univ., Ctr. for Behavioral Neurosci., Yerkes 

Natl. Primate Res. Ctr. 

11:00 DDD6 387.4 • Opioid regulation of pair bonding in the 

monogamous prairie vole. S. L. HARKEY*; A. B. BROCK; 

M. KUEHNMUNCH; T. KRZYWOSINSKI; M. A. MITRY; B. J. 

ARAGONA. Univ. Michigan. 



8:00 DDD7 387.5 • Octopamine levels correlate with 

population level differences in social structure in a polyphenic 

spider. J. B. PRICE*; T. C. JONES; D. S. ROANE. East 

Tennessee State Univ. 

9:00 DDD8 387.6 Variation in enkephalin immunoreactivity 

in the social behavior network and song system in male 

European Starlings (Sturnus vulgaris) is dependent on 

breeding state. T. J. STEVENSON*; G. F. BALL. Johns 

Hopkins Univ. 

10:00 DDD9 387.7 R5020, a synthetic progestin, disrupts 

social discrimination in adult male rats. M. E. BYCHOWSKI*; 

C. J. AUGER. Univ. Wisconsin. 

11:00 DDD10 387.8 Epigenetic control of vasopressin 

expression in the adult male rat within the bed nucleus of the 

stria terminalis. C. J. AUGER*; D. COSS; A. P. AUGER; R. M. 

FORBES-LORMAN. Univ. Wisconsin. 

8:00 EEE1 387.9 � Evolutionary remains: Differences 

in heritability of forebrain V1aR. W. L. WEYMOUTH*; E. 

RICHMAN; S. PHELPS. Univ. of Florida. 

9:00 EEE2 387.10 A socio-spatial memory neural circuit 

predicts male monogamy in the field. A. G. OPHIR*; A. 

GESSEL; D. ZHENG; S. M. PHELPS. Oklahoma State Univ., 

Univ. of Florida. 

10:00 EEE3 387.11 Single nucleotide polymorphisms and 

microsatellites in the avpr1a promoter: Novel associations with 

neuronal V1aR among wild prairie voles. S. M. PHELPS*; N. 

LYSACK. Univ. Florida. 

11:00 EEE4 387.12 Evolution of cis-regulatory variation at the 

avpr1a locus and its pseudogene. A. BERRIO*; N. S. LYSAK; 

D. V. BLONDEL; J. L. PINO; S. M. PHELPS. Dept. of Biology/ 

University of Florida. 

8:00 EEE5 387.13 Regulation of social recognition by 

vasopressin: Age- but not sex-specific effects. A. H. 

VEENEMA*; R. BREDEWOLD; G. J. DE VRIES. Univ. of 

Massachusetts, Amherst, Boston Col. 

9:00 EEE6 387.14 Effects of chronic social defeat stress on 

fos activation, vasopressin levels and anxiety-like behaviors 

in a novel social investigation model. G. MURAKAMI*; C. G. 

FONTAINE; D. W. PFAFF; Y. LITVIN. Lab. of Neurobio. and 

Behavior, The Rockefeller Univ. 

10:00 EEE7 387.15 Development of transgenic prairie voles 

(Microtus ochrogaster) expressing shRNA’s targeting the V1a 

vasopressin receptor. C. E. BARRETT*; Z. DONALDSON; 

S. YANG; A. W. S. CHAN; L. J. YOUNG. Prog. in Neurosci., 

Emory Univ., Columbia Univ., Natl. Cheng-Kung Univ. 

11:00 EEE8 387.16 Expression of immediate early gene 

protein (Egr-1 protein) in vasopressin neurons of the rat 

anterior olfactory nucleus following social odour exposure. M. 

LUDWIG*; D. WACKER; V. TOBIN; J. NOACK; V. BISHOP; 

M. ENGELMANN; S. MEDDLE. Univ. Edinburgh, Univ. of 

Magdeburg. 

8:00 EEE9 387.17 Sniffing oxytocin: About mechanisms 

and brain effects. J. G. VEENING*; B. OLIVIER. UMC St 

Radboud, Div. of Pharmacology, UIPS, Utrecht Univ., Yale 

Univ. Sch. of Med. 

9:00 EEE10 387.18 Oxytocin and happiness. R. MERLIN*; D. 

GROSBERG; P. J. ZAK. Claremont Grad. Univ. 

10:00 FFF1 387.19 Oxytocin infusion increases charitable 

donations regardless of monetary resources. J. A. 

BARRAZA*; M. E. MCCULLOUGH; S. AHMADI; P. J. ZAK. 

Ctr. for Neuroeconomics Studies, Univ. of Miami, UCLA, 

Claremont Grad. Univ. 



11:00 FFF2 387.20 The impact of childhood trauma on 

oxytocin release and trustworthiness. E. T. TERRIS*; 

N. MAHONEY; M. J. VERCOE; P. J. ZAK. Ctr. For 

Neuroeconomics Studies, Scripps Col. 

8:00 FFF3 387.21 Oxytocin increases the influence 

of advertising. P. LIN*; N. SPARKS; C. MORIN; W. D. 

JOHNSON; P. J. ZAK. Claremont Grad. Univ., Fielding Grad. 

Sch., Loma Linda University, Med. Ctr. 

9:00 FFF4 387.22 Massage increases oxytocin and 

decreases stress in humans. L. E. BEAVIN*; V. MORHENN; 

P. J. ZAK. Ctr. For Neuroeconomic Studies, Claremont Grad. 

Univ., UC San Diego Med. Ctr. 

10:00 FFF5 387.23 The influence of social interaction on 

oxytocin receptor expression in mice. B. L. JARRETT*; K. 

KARELINA; K. STULLER; *. A. C. DEVRIES. Ohio State Univ. 

11:00 FFF6 387.24 The effect of oxytocine on the amygdalar 

spontaneous EEG activity of freely moving male rats. S. 

DEMIRGOREN*; O. ERBAS; G. PEKER. Ege University, Fac. 

of Med. 

8:00 FFF7 387.25 Oxytocin enhances pup’s contact with 

mother, which augments hypothalamic OT and mediates 

acquisition of huddling preference for maternal odor in rat 

pups. S. KOJIMA*; J. R. ALBERTS. Indiana Univ. 

9:00 FFF8 387.26 Paradoxical effects of chronic estrogen 

treatment on central and peripheral oxytocin in female prairie 

voles. J. R. STEVENSON*; H. P. NAZARLOO; J. VAN 

HEUSDEN; J. R. YEE; W. M. KENKEL; S. CARTER. Univ. of 

Illinois At Chicago, Bucknell Univ. 

POSTER 

388. Acute and Chronic Intermittent hypoxia 



8:00 FFF9 388.1 Effects of chronic intermittent hypoxia 

on benzodiazepine-sensitive GABAergic modulation of the 

chemoreceptor reflex in rats. M. SUZUKI*; M. NISHINA; 

S. NAKAMURA; K. YOSHIMURA. Saitama Med. Univ., JA 

Kumagaya Gen Hosp, Nihon Inst. Med. Sci. 

9:00 FFF10 388.2 Activation of adenosine A2A receptor on 

glutamatergic inputs to second-order neurons of peripheral 

chemoreceptors in the NTS. W. ZHANG*; C. YUAN; S. 

MIFFLIN. Univ. of North Texas Hlth. Sci. Ctr. At Fort Worth. 

10:00 FFF11 388.3 Destruction of serotonergic neurons in 

the medullary raphe blunts arousal in response to intermittent 

hypoxia. R. A. DARNALL*; R. W. SCHNEIDER; K. G. 

COMMONS; C. M. TOBIA. Dartmouth Med. Sch., Childrens 

Hosp. and Harvard Med. Sch. 

11:00 FFF12 388.4 Modulation of carotid body chemoreceptor 

gain by transient receptor potential vallinoid type I (TRPV1) 

receptor agonists: Possible therapeutics for sleep apnea. 

A. ROY*; S. MANDADI; M. FIAMMA; E. RODIKOVA; P. 

WHELAN; E. V. FERGUSON; R. J. A. WILSON. Hotchkiss 

Brain Institute, Univ. of Calgary. 

8:00 FFF13 388.5 Hypoxia induces singlet breathing pattern 

in red-eared NANOSYMPOSIUMr turtles. S. M. JOHNSON*. 

Univ. Wisconsin Madison. 

9:00 FFF14 388.6 Postnatal development of adenosinergic 

pathways in the central cardio-respiratory related areas of the 

rat, after neonatal exposure to caffeine. R. PASARO*; S. P. 

GAYTAN. Univ. of SeVilla. 


Mon. AM

10:00 FFF15 388.7 PAC1 and VPAC2 receptors are involved 

in pituitary adenylate cyclase-activating peptide (PACAP) 

stimulation of the carotid body. E. RODIKOVA*; A. ROY; K. 

J. CUMMINGS; D. ZINYK; C. J. SCHUURMANS; R. J. A. 

WILSON. Univ. of Calgary, Dartmouth Med. Sch. 

11:00 FFF16 388.8 Efferents from medial and commissural 

nuclei (SolM, SolC) of the rat nucleus of the solitary tract 

(NTS) target the ventral respiratory group (VRG) and regions 

adjacent to the facial nucleus while avoiding the Bötzinger 

and preBötzinger complex. G. F. ALHEID*; W. JIAO; D. R. 

MCCRIMMON. Northwestern Univ. Feinberg Sch. of Med. 

8:00 FFF17 388.9 Peripheral and central respiratory 

responses to pituitary adenylate cyclase-activating peptide 

(PACAP) in the neonatal rat. E. V. FERGUSON*; A. ROY; B. 

ZHANG; R. J. A. WILSON. Univ. of Calgary. 

9:00 FFF18 388.10 Multichannel recording in dorsolateral 

pons revealed neurons involved in hypoadditive interaction 

between central and peripheral respiratory chemoreflex 

inputs. C. TIN*; G. SONG; M. A. ADAMS; C. POON. M.I.T. 

10:00 FFF19 388.11 Mechanisms involved in the reduction of 

afferent transmission in the nucleus tractus solitarii induced 

by chronic intermittent hypoxia in rats. C. E. ALMADO*; B. 

H. MACHADO; R. M. LEÃO. Sch. of Med. of Ribeirão Preto - 

Univ. of São Paulo. 

11:00 FFF20 388.12 Chronic intermittent hypoxia induces 

NMDA receptor-dependent plasticity and suppresses nitric 

oxide signaling in the mouse hypothalamic paraventricular 

nucleus. C. G. COLEMAN*; G. WANG; L. PARK; G. J. 

DELAGRAMMATIKAS; J. CHAN; C. IADECOLA; V. PICKEL. 

Cornell Univ. Weill Med. Coll, The Cooper Union. 

8:00 FFF21 388.13 Cardiovascular responses to acute and 

chronic tracheal occlusions in conscious rats. P. JAISWAL; K. 

PATE; H. DEOGHARE; D. SCHEUER; P. W. DAVENPORT*. 

Univ. Florida. 

9:00 FFF22 388.14 Lack of hippocampal VEGF and VEGFR2 

expression in the hypoxia tolerant naked mole rat. D. P. 

MCCLOSKEY*; S. GOLDMAN; B. GOLDMAN. Col. Staten 

Island/ CUNY, Univ. of Connecticut. 

10:00 GGG1 388.15 Antiangiogenic effects of betaadrenoreceptor 

blockade in a mouse model of retinopathy 

of prematurity. P. BAGNOLI*; C. RISTORI; D. MARTINI; P. 

FIORINI; L. FILIPPI. Univ. of Pisa, “A. Meyer” Univ. Children’s 

Hosp. 

11:00 GGG2 388.16 Hypoxia-induced body temperature 

reduction depends on the phase of day. C. S. SCARPELLINI*; 

T. ANGELI; L. H. GARGAGLIONI; K. C. BICEGO. UNESP. 

8:00 GGG3 388.17 Morphological changes of gliovascular 

networks induced by chronic hypoxia in mouse cerebral 

cortex. K. MASAMOTO*; H. TAKUWA; T. OBATA; M. 

UNEKAWA; H. TORIUMI; Y. TOMITA; N. SUZUKI; I. KANNO. 

Univ. Electro-Communications, Natl. Inst. of Radiological Sci., 

Sch. of Med. Keio Univ. 

POSTER 

389. Cellular Actions of Stress I 



8:00 GGG4 389.1 Mechanisms of rapid dendritic spine loss 

induced by corticotropin releasing hormone signaling. A. L. 

ANDRES*; Y. CHEN; Y. NOAM; L. PHAN; T. Z. BARAM. Univ. 

of California Irvine. 

9:00 GGG5 389.2 Mechanisms of rapid, stress-related 

dendritic spine loss in adult hippocampus. Y. CHEN*; L. Y. 

CHEN; A. L. ANDRES; B. LEE; L. PHAN; C. M. GALL; T. Z. 

BARAM. Univ. Cal Irvine. 

10:00 GGG6 389.3 The novel neuropeptide, teneurin 

C-terminal associated peptide (TCAP)-1, increases 

hippocampal CA3 dendrite spine density and decreases 

anxiety-like behaviour in rats. L. A. TAN*; A. AL CHAWAF; 

F. J. VACCARINO; S. ROTZINGER; D. A. LOVEJOY. Univ. 

Toronto. 

11:00 GGG7 389.4 Teneurin C-terminal associated peptide 

(TCAP)-1 mediates regulation of brain-derived neurotrophic 

factor (BDNF). T. S. NG*; J. WATSON; P. C. BOUTROS; D. A. 

LOVEJOY. Univ. of Toronto, Ontario Inst. of Cancer Res. 

8:00 GGG8 389.5 Expression and characterization of 

the newly elucidated teneurin C-terminal associated 

peptide (TCAP) in the hippocampus of the mouse brain. 

D. S. CHAND; A. KOLLARA; L. SONG; T. J. BROWN; D. 

BARSYTE-LOVEJOY; D. A. LOVEJOY*. Univ. of Toronto, 

Univ. Of Toronto, Samuel Lunenfeld Res. Institute, Mount 

Sinai Hosp. 

9:00 GGG9 389.6 Running may reduce anxiety-like behavior 

by altering afferent input and activating inhibitory interneurons 

in the hippocampus. T. J. SCHOENFELD*; B. HSUEH; E. 

GOULD. Princeton Univ. 

10:00 GGG10 389.7 Region-specific response of the 

hippocampus to chronic unpredictable stress. D. HAWLEY*; J. 

LEASURE. Univ. of Houston. 

11:00 GGG11 389.8 The role of the medial prefrontal cortex in 

dorsal raphe nucleus 5-HT1A receptor adaptation following 

escapable and inescapable stress. R. R. ROZESKE*; L. 

R. WATKINS; C. A. LOWRY; S. F. MAIER. Univ. Colorado- 

Boulder, Univ. of Colorado-Boulder. 

8:00 GGG12 389.9 Trafficking of corticotropin-releasing factor 

receptors in rat locus coeruleus neurons in a model of social 

stress. T. A. RETSON*; S. K. WOOD; B. A. S. REYES; R. J. 

VALENTINO; E. J. VAN BOCKSTAELE. Thomas Jefferson 

Univ., Children’s Hosp. of Philadelphia, Philadelphia. 

9:00 GGG13 389.10 Acute stress down-regulates expression of 

retransposon mRNA in the rat hippocampus. R. G. HUNTER*; 

B. S. MCEWEN; D. W. PFAFF. Rockefeller Univ. 

10:00 GGG14 389.11 Stress induced priming of glutamate 

synapses unmasks associative short-term plasticity. J. 

KUZMISKI*; V. MARTY; D. BAIMOUKHAMETOVA; J. BAINS. 

Univ. Calgary, UCLA. 

11:00 GGG15 389.12 The neuroprotective protein 

carboxypeptidase e is up regulated in the hippocampus 

during chronic restraint stress. S. R. K. MURTHY; W. 

LI; E. THOUENNON; J. BHUPATKAR; M. LANE; I. 

MERCHENTHALER; Y. LOH*. NICHD, NIH, Sun Yat-Sen 

Univ., NICHD NIH, Univ. of Maryland. 

8:00 GGG16 389.13 Carboxypeptidase E is neuroprotective 

against epileptic-like seizures in mouse hippocampal neurons. 

N. X. CAWLEY; A. WORONOWICZ; H. GAINER*; Y. LOH. 

Eunice Kennedy Shriver NICHD, NIH/NINDS. 

9:00 GGG17 389.14 Repeated corticosterone pulses in vitro 

change the ratio of MR and GR mediated rapid effects in the 

basolateral amygdala but not hippocampus. H. KARST*; N. 

PASRICHA; M. JOËLS. Univ. Med. Ctr. Utrecht. 

10:00 GGG18 389.15 Effects of stress on dendritic morphology 

of CA3 pyramidal neurons in the pregnant female rat. J. 

PAWLUSKI*; A. I. M. SANTOS; A. VALENCA; J. COSTA- 

NUNES; H. W. M. STEINBUSCH; T. STREKALOVA. 

Maastricht Univ., Univ. Nova de Lisboa, Lisboa Univ. 



11:00 GGG19 389.16 • Reduced GRK3 levels in locus coeruleus 

after unpredictable inescapable stress is associated with 

increased stress susceptibility. M. TANEJA; K. SAHA; D. C. 

EIKENBURG*. Univ. Houston. 

8:00 GGG20 389.17 Responses to mild variable stress of Ucn1 

neurons and their synaptic input in the rat non-preganglionic 

Edinger-Westphal nucleus. D. VAN WIJK*; B. GASZNER; L. 

A. M. H. KIRKELS; K. MEIJER; T. KOZICZ; E. W. ROUBOS. 

Radboud Univ. Nijmegen, Pécs Univ. 

9:00 GGG21 389.18 Maintenance of retrograde 

endocannabinoid signaling at synapses onto hypothalamic 

neuroendocrine cells reflects age-specific adaptation to stress. 

J. I. WAMSTEEKER*; J. B. KUZMISKI; J. S. BAINS. Univ. 

Calgary. 

10:00 GGG22 389.19 Rapid synaptic modulation of 

hypothalamic neurons by glucocorticoids requires the 

glucocorticoid receptor. J. HAAM*; K. C. HALMOS; L. J. 

MUGLIA; J. G. TASKER. Tulane Univ., Vanderbilt Univ. Med. 

Ctr. 

11:00 HHH1 389.20 Heterosynaptic mGluR-dependent longterm 

potentiation of GABAergic synaptic transmission in rat 

hypothalamic parvocellular neuroendocrine cells. W. INOUE*; 

Q. J. PITTMAN; J. S. BAINS. Hotchkiss Brain Institute, Dept. 

of Physiol. & Pharmacology, Univ. O. 

8:00 HHH2 389.21 Repeated stress suppresses glutamate 

receptor expression and function in prefrontal cortex and 

impairs object recognition memory. E. Y. YUEN*; J. WEI; Z. 

YAN. SUNY Buffalo. 

9:00 HHH3 389.22 Increased susceptibility to the 

depressogenic effects of corticosterone in heterozygous 

reeler mice. A. L. LUSSIER*; R. ROMAY-TALLÓN; H. J. 

CARUNCHO; L. E. KALYNCHUK. Univ. Saskatchewan, Univ. 

of Santiago de Compostela. 

10:00 HHH4 389.23 � Insulin-induced hypoglycemia is 

associated with ERK phosphorylation in locus coeruleus 

neurons: Implications for arousal triggered by metabolic 

stress. C. JAYEWICKREME; A. RAMCHANDANI; G. SI; A. M. 

KHAN*. USC. 

POSTER 

390. Stress and Cognition I 



8:00 HHH5 390.1 Effects of chronic and acute restraint 

stress on PKMζ in male and female rats. V. N. LUINE*; V. 

SEBASTIAN; J. B. ESTIL; A. CHOWDHURY; J. GOMEZ; P. 

SERRANO. Hunter Col. 

9:00 HHH6 390.2 Stress induced memory deficits in male 

but not female rats mediated by the long-term memory protein 

PKMζ. P. A. SERRANO*; T. GOLDSTEIN; R. BAIG; V. LUINE; 

L. M. SCHROTT. Hunter Col. and City Univ. of New York, 

Louisiana State University, Hlth. Sci. Ctr. 

10:00 HHH7 390.3 Spatial learning and PKMζ activity in 

mormyrid electric fish (Mormyridae, Teleostei): Gnathonemus 

petersii Günther and Mormyrus rume proboscirostris 

Boulenger. P. MOLLER*; A. CHOWDHURY; K. FATOVA; F. 

NARUZZAMAN; P. A. SERRANO. Hunter Col. City of New 

York. 



11:00 HHH8 390.4 � Postnatal opiate withdrawal and immune 

activation stress alter markers of synaptic plasticity. A. 

CHOWDHURY*; P. A. SERRANO; L. M. FRANKLIN; G. S. 

JOHNSON; L. M. SCHROTT. Hunter Col. and City Univ. of 

New York, Louisiana State University, Hlth. Sci. Ctr. 

8:00 HHH9 390.5 PKMζ activity promotes early life traumatic 

memory formation and retention. C. P. WIEDENMAYER*; H. 

N. SHAIR; P. A. SERRANO. Columbia Univ., Hunter College, 

City Univ. of New York. 

9:00 HHH10 390.6 Delineation of the molecular profile of 

the effects of intense exercise training on neurogenesis. K. 

INOUE*; R. RAKWAL; M. LEE; M. OKAMOTO; H. SOYA. 

Univ. of Tsukuba, Univ. of Toho. 

10:00 HHH11 390.7 Stress and “cognitive enrichment” 

modulate hippocampal to pfc theta synchrony. N. S. 

DIAS; J. F. OLIVEIRA; V. PINTO; O. F. X. ALMEIDA; J. J. 

CERQUEIRA*; N. SOUSA. Sch. of Hlth. Sci., Max Planck Inst. 

of Psychiatry. 

11:00 HHH12 390.8 � Glucocorticoid receptors are localized 

in dendritic spines of hippocampal CA1 pyramidal neurons: 

Evidence for dysregulation in a mouse model of Fragile X. 

M. JAFARI; R. R. SEESE; E. HANDLER; C. M. GALL; J. C. 

LAUTERBORN*. Univ. California Irvine Sch. Med. 

8:00 HHH13 390.9 Defects of hippocampal structure and 

function presage memory impairments after early-life stress. 

A. S. IVY*; Y. JIA; K. FOK; A. CHO; G. LYNCH; T. Z. BARAM. 

Univ. California-Irvine, Univ. California- Irvine. 

9:00 HHH14 390.10 Stress coping stimulates hippocampal 

neurogenesis in adult monkeys. D. M. LYONS*; P. 

S. BUCKMASTER; A. LEE; C. WU; R. MITRA; L. M. 

DUFFEY; C. L. BUCKMASTER; S. HER; P. D. PATEL; A. F. 

SCHATZBERG. Stanford Univ. Med. Sch. 

10:00 HHH15 390.11 Preventive effects of oxytocin on impaired 

synaptic plasticities and memory impairments by stress might 

be related to ERK signaling, not to GR signaling. S. LEE; W. 

CHO; S. PARK; S. CHOI; J. HAN*. Konkuk Univ., Col. of Dent. 

and Dent. Res. Institute, Seoul Natl. Univ. 

11:00 HHH16 390.12 Protective effects of environmental 

enrichment, initiated before or during chronic stress, on 

cognitive and morphological measures of hippocampal 

integrity. K. M. HUTCHINSON*; K. J. MCLAUGHLIN; R. L. 

WRIGHT; D. P. ANOUTI; J. B. ORTIZ; A. MIKA; T. N. HUYNH; 

J. J. HANNA; D. M. DIAMOND; C. D. CONRAD. Arizona State 

Univ., Loras Col., Univ. of South Florida, VA Hosp. 

8:00 HHH17 390.13 The effects of chronic stress, sex 

differences and light phase on anxiety and depressive-like 

behaviors. T. N. HUYNH*; A. M. KRIGBAUM; J. J. HANNA; A. 

MIKA; A. N. HOFFMAN; J. B. ORTIZ; N. S. CONBOY; C. D. 

CONRAD. Arizona State Univ., New York Univ. 

9:00 HHH18 390.14 Recovery of hippocampal CA3 dendritic 

retraction and correspondence to spatial learning and 

memory after chronic stress in mature adult male rats. A. 

N. HOFFMAN*; D. P. ANOUTI; K. M. HUTCHINSON; A. 

M. KRIGBAUM; J. B. ORTIZ; A. MIKA; J. J. HANNA; H. A. 

BIMONTE-NELSON; C. D. CONRAD. Arizona State Univ. 


Mon. AM

POSTER 

391. food Intake and Energy Balance: Integration of 

Peripheral Signals II 



8:00 HHH19 391.1 Differential neural response to food cues 

during fasting and fed states. A. DIMITROPOULOS*; J. 

KENNEDY; A. HO. Case Western Reserve Univ. 

9:00 HHH20 391.2 • Correlations of body mass index with 

neurological activity to food cues when hungry and satiated. 

J. KENNEDY*; A. HO; A. DIMITROPOULOS. Case Western 

Reserve Univ. 

10:00 HHH21 391.3 Food intake and body weight in rats - 

Dysregulation by sleep deprivation and sleep restriction. 

M. KOBAN*; J. C. BRADFORD; W. LE; G. E. HOFFMAN. 

Morgan State Univ. 

11:00 HHH22 391.4 Modulation of synaptic transmission 

by nicotine, serotonin and amylin in the area postrema. 

T. FUKUDA*; Y. KITAGAWA; M. FUNAHASHI. Dept. of 

Oral Physiology, Hokkaido Univ. Grad. Sch. of Dent. Med., 

Hokkaido University, Grad. Sch. of Dent. 

8:00 HHH23 391.5 A peripheral endocannabinoid mechanism 

enhances dietary fat intake. N. V. DIPATRIZIO*; G. ASTARITA; 

X. LI; G. J. SCHWARTZ; D. PIOMELLI. Univ. of California, 

Irvine, Albert Einstein Col. of Med., Italian Inst. of Technol. 

9:00 HHH24 391.6 The endocannabinoid anandamide 

ameliorates specific lipopolysaccharide-induced changes 

in physiology and Fos expression within hypothalamic and 

mesolimbic systems. J. H. HOLLIS*; H. JONAIDI; M. LEMUS; 

B. J. OLDFIELD. Monash Univ., Shahid Bahonar Univ. of 

Kerman. 

10:00 HHH25 391.7 Smooth muscle-specific knockout of brainderived 

neurotrophic factor results in hyperphagia and obesity. 

E. A. FOX*; J. E. BIDDINGER; K. R. JONES; A. WORMAN; J. 

MCADAMS. Purdue Univ., Univ. of Colorado. 

11:00 HHH26 391.8 Effects of fasting on the spatiotemporal 

coding in the olfactory bulb. M. BENDAHMANE*; C. MARTIN; 

C. BALY; D. DURIEUX; M. CAILLOL; H. GURDEN. Umr8165- 

Imagerie Et Modélisation En Neurobiologie Et Cancérologie, 

Neurobiologie de l’Olfaction et Modélisation en Imagerie. 

8:00 HHH27 391.9 Dissecting vagal afferent pathways 

mediating the incretin and anorectic effects of glucagonlike-peptide-1 

receptor activation. M. R. HAYES*; A. 

L. ALHADEFF; T. M. LEICHNER; H. J. GRILL. Univ. 

Pennsylvania. 

9:00 HHH28 391.10 Meal pattern and microstructure changes 

underlying hyperphagia and obesity in mice with smooth 

muscle-specific brain-derived neurotrophic factor knockout. J. 

E. BIDDINGER*; E. A. FOX. Purdue Univ. 

10:00 HHH29 391.11 Agouti-related peptide and estrogen 

receptor alpha are co-localized within the arcuate nucleus of 

the rat: Role of estradiol. R. GALLAGHER*; L. J. MONDINO; 

E. D. GRISLEY; M. L. SMITH; J. L. CHEATWOOD; A. D. 

STRADER. Southern Illinois Univ., Virginia Tech. Univ. 

11:00 HHH30 391.12 Brain signaling in reward deficiency; the 

effect of cognitive dietary restraint on the rewarding value of 

food. J. M. BORN*; S. G. T. LEMMENS; M. J. I. MARTENS; 

E. FORMISANO; R. GOEBEL; M. S. WESTERTERP- 

PLANTENGA; M. S. WESTERTERP-PLANTENGA. 

Maastricht Univ., Top Inst. Food and Nutr. 

8:00 HHH31 391.13 FMRI BOLD response to intragastric 

load of alcohol, glucose, NaCl, and amino acid solutions 

in conscious rats. T. TSURUGIZAWA*; A. UEMATSU; A. 

KITAMURA; H. UNEYAMA; K. TORII. Ajinomoto Co., Inc. 

9:00 HHH32 391.14 Sucrolose creates hyperinsulimic-like 

weight gain in food restricted rats. A. K. THAW*; N. MANN. 

Millsaps Col. 

10:00 HHH33 391.15 Gestational programming of behavioral 

and neuroendocrine systems responsible for energy 

homeostasis in Syrian hamster offspring prenatally exposed to 

reduced fuel availability. E. KEEN-RHINEHART*; K. PATEL; J. 

E. SCHNEIDER. Susquehanna Univ., Lehigh Univ. 

11:00 HHH34 391.16 Metabolic disturbances after chronic social 

defeat stress. M. L. LUTTER*; J. CHUANG. UT Southwestern. 

8:00 HHH35 391.17 The inhibitory effect of estradiol on food 

intake does not differ with varying time points of hormonal 

withdrawal. J. C. SANTOLLO*; L. A. ECKEL. Florida State 

Univ. 

POSTER 

392. Energy Metabolism I 



8:00 HHH36 392.1 Lactate during slice incubation improves 

neuronal function during subsequent low glucose exposure. P. 

K. SHETTY AMPAR*; F. GALEFFI; D. A. TURNER. Duke Univ. 

Med. Center, and Durham VAMC. 

9:00 HHH37 392.2 Prion protein expression modulates 

cellular energy metabolism. B. WONG*; M. LIM; R. S. LOH. 

Natl. Univ. of Singapore. 

10:00 HHH38 392.3 Simultaneous monitoring of tissue Po 2 and 

NADH fluorescence during synaptic stimulation and spreading 

depression reveals a transient dissociation between oxygen 

utilization and mitochondrial redox state in rat hippocampal 

slices. F. GALEFFI*; G. G. SOMJEN; D. A. TURNER. Duke 

Univ. Med. Ctr., DVMC, DVAMC. 

11:00 HHH39 392.4 • Neuronal overexpression of ICER in 

transgenic rat model; the impact on seizure susceptibility 

and glucose metabolism. A. KLEJMAN*; K. BIEGANSKA; 

M. WAWRZYNIAK; M. DąBROWSKI; D. OWCZAREK; P. 

LISOWSKI; M. BALCERZYK; L. KACZMAREK. Nencki Inst. 

of Exptl. Biol., Polish Acad. of Sci. Inst. of Genet. and Animal 

Breeding, Univ. Compultense de Madrid. 

8:00 HHH40 392.5 Establishment of transgenic mice that 

overexpress monocarboxylate transporter-1 (MCT-1) in 

astrocytes: A role for astroglial in obesity/body metabolism. Y. 

LEE; L. JIN*; J. D. ROTHSTEIN. Johns Hopkins Med. Inst. 

9:00 HHH41 392.6 The biological clock modulates the 

sensitivity of the ARC to negative metabolic conditions. D. 

HERRERA MORO*; G. ACOSTA GALVÁN; C. ESCOBAR 

BRIONES; R. SALGADO DELGADO; M. BASUALDO 

SIGALES; R. M. BUIJS. Biomed. Res. Inst., Med. Fac. 

10:00 HHH42 392.7 Ketamine-Xylazine-induced inhibition of 

neuronal activity increases brain energy levels in sleep-wake 

related brain regions. M. DWORAK; R. W. MCCARLEY; T. 

KIM; R. BASHEER*. Harvard Univ./Boston VAMC. 

11:00 HHH43 392.8 Glucose metabolism in a mouse model 

with alpha ketoglutarate dehydrogenase complex reduction. 

L. H. NILSEN; Q. SHI; G. E. GIBSON; M. P. WITTER*; U. 

SONNEWALD. Norw. Univ. Sci. & Tech., Weill Cornell Med. 

College/Burke Med. Res. Inst. 



8:00 HHH44 392.9 Glucose utilization and Ca2+ imaging 

in cultured hippocampal neurons. T. PANCANI*; K. L. 

ANDERSON; L. D. BREWER; O. THIBAULT. Univ. Kentucky 

Med. Ctr. 

9:00 HHH45 392.10 • Necdin regulates Foxo1 acetylation 

via Sirt1 in mouse hypothalamus. K. HASEGAWA*; K. 

YOSHIKAWA. Osaka Univ. 

10:00 HHH46 392.11 In vivo evidence for lactate as cerebral 

energy source. A. BUCK*; M. WYSS; P. J. MAGISTRETTI; B. 

WEBER. Univ. Hosp Zurich, EPFL, Univ. of Zurich. 

11:00 HHH47 392.12 Corticotropin-releasing factor receptor type 

2 activation in the ventromedial hypothalamus is required for 

energy balance regulation following metabolic challenges. Y. 

KUPERMAN*; O. ISSLER; D. GETSELTER; S. GIL; A. CHEN. 

Weizmann Inst. of Sci. 

8:00 HHH48 392.13 Lipoprotein receptor LRP1 regulates leptin 

signaling and energy homeostasis in the adult central nervous 

system. Q. LIU*; J. ZHANG; Y. ZHAN; C. ZERBINATTI; B. 

KOLBER; L. MUGLIA; J. HERZ; G. BU. Washington Univ. in 

St.Louis, Univ. of Texas Southwestern Med. Ctr. 

9:00 III1 392.14 Hindbrain catecholamine neurons are 

required for rapid switching of metabolic substrate utilization 

during glucoprivation. A. LI; Q. WANG; T. T. DINH; S. 

RITTER*. Washington State Univ. 

10:00 III2 392.15 Novel Oligodendroglial Biology: 

Unexpected discovery of monocarboxylate transporter-1 

(MCT-1) expression predominately in oligodendrocytes in 

vivo. Y. LEE*; L. JIN; J. D. ROTHSTEIN. Johns Hopkins Sch. 

of Med. 

11:00 III3 392.16 Application of qPCR and highsensitivity 

immunoblot analyses to laser-microdissected A2 

noradrenergic neurons reveals adaptation of dopaminebeta-hydroxylase, 

substrate transporter, glucokinase, and 

phosphorylated AMPK responses to recurring NPH-induced 

hypoglycemia. A. KOSHY CHERIAN; K. P. BRISKI*. Coll 

Pharm, Univ. Louisiana Monroe. 

8:00 III4 392.17 Bioinformatics study of tracing the 

mysterious disappearance of polyphosphate kinase in 

mammalian neural cells. Z. WEI*; Y. H. NIE; J. L. HUANG; J. 

L. TENG; J. G. CHEN; A. C. H. YU. Neurosci. Res. Institute, 

Peking Univ., Col. of Life Sciences, Peking Univ. 

9:00 III5 392.18 The roles of antioxidant enzymes in 

regulation of mitochondrial function in the brain. D. HYUN*; E. 

KO; S. PARK; J. LEE; S. YIM; S. RHEE. Ewha Womans Univ. 

10:00 III6 392.19 High resolution mapping of genetic 

loci regulating daily physical activity in mice. H. YANG*; 

K. SHIMOMURA; M. H. VITATERNA; F. W. TUREK. 


11:00 III7 392.20 Withdrawn 

8:00 III8 392.21 • � Acute administration of the 

antipsychotic olanzapine increases the plasma glucose 

concentration and induces hepatic insulin resistance 

in male rats. Peripheral (intragastric) versus central 

(intracerebroventricular). E. M. GIRAULT*; E. FOPPEN; M. T. 

ACKERMANS; E. FLIERS; A. KALSBEEK. Netherlands Inst. 

For Neurosci., Academic Med. Center, Univ. of Amsterdam. 

9:00 III9 392.22 Cytochrome oxidase activity, Na + /K + - 

ATPase activity and GABA-immunoreactivity in the central 

nervous system of an anoxia-tolerant land snail during anoxia 

and reoxygenation. L. S. DE FRAGA*; B. P. COELHO; A. S. 

GONÇALVES; W. A. PARTATA; M. ACHAVAL; R. S. M. DA 

SILVA; D. M. ZANCAN. Federal Univ. of Rio Grande Do Sul. 



10:00 III10 392.23 • High-fat diet induced insulin resistance 

in the brain is mediated by elevated levels of IL-6. T. 

SARTORIUS*; A. M. HENNIGE; S. Z. LUTZ; C. WEIGERT; H. 

RAMMENSEE; H. HAERING. Dept. of Intrnl. Med. 4, Inst. for 

Cell Biol. 

11:00 III11 392.24 Neuro-metabolic coupling following 

multiple spreading depolarizations - Combination of laser 

speckle flowmetry, positron emission tomography and 

microdialysis. D. FEUERSTEIN; M. GRAMER; T. KUMAGAI; 

M. SUÉ; S. VOLLMAR; A. J. STRONG*; H. BACKES; R. 

GRAF. MPI for Neurolog. Res., Kings Col. London. 

POSTER 

393. Perception and Imagery: face and Object Processing 



8:00 III12 393.1 Effects of plantar perceptual learning 

involving a discrimination task on brain activity: A functional 

near-infrared spectroscopy study. H. NAKANO*; S. 

MORIOKA. Kio Univ. 

9:00 III13 393.2 Preference for symmetry: Only on Mars? 

K. SHEPHERD*; M. BAR. MGH / Harvard Med. Sch. 

10:00 III14 393.3 The predictive role of orbitofrontal cortex 

as derived from its response to visual, meaning and affective 

information. M. CHAUMON*; K. KVERAGA; L. FELDMAN 

BARRETT; M. BAR. Mass Gen. Hosp. 

11:00 III15 393.4 Visual object representations in ventral 

cortex of an object agnosic patient. C. S. KONEN*; M. 

NISHIMURA; M. BEHRMANN; S. KASTNER. Princeton Univ., 


8:00 III16 393.5 • A modeling approach for assessing the 

cortical and perceptual consequences of age-related macular 

degeneration. J. SHI*; J. WIELAARD; R. SMITH; P. SAJDA. 


9:00 III17 393.6 • Perception of emotional face expressions 

by elderly suffering from Alzheimer’s Disease. W. C. 

DE SOUZA*; R. L. LEONARDO; F. M. DA SILVA; J. G. 

GUIMARAES; R. V. C. MAGALHAES. Univ. Brasilia. 

10:00 III18 393.7 Spatio-temporal fMRI evidence for an 

early top-down biasing mechanism in the right fusiform face 

area. F. JIANG*; G. RIGHI; R. GOEBEL; B. ROSSION. Univ. 

Louvain, Children’s Hosp. Boston, Maastricht Univ. and Brain 

Imaging Ctr. 

11:00 III19 393.8 Dissociable electrophysiological 

responses to faces and bodies recorded from subdural 

electrodes on human occipitotemporal cortex. A. D. ENGELL*; 

G. MCCARTHY. Yale Univ. 

8:00 III20 393.9 • Reach trajectories reveal early processing 

of low spatial frequency faces. B. AWASTHI*; J. FRIEDMAN; 

M. A. WILLIAMS. Macquarie Ctr. for Cognitive Science, 

Macquarie Univ. 

9:00 III21 393.10 What human brain regions like about 

moving faces. J. SCHULTZ*; M. BROCKHAUS; K. S. PILZ. 

MPI Biol. Cybernetics, Univ. of Tuebingen, McMaster Univ. 

10:00 III22 393.11 • Measuring the familiarity of faces with 

event-related potentials. J. O. TOURYAN*; L. GIBSON; J. H. 

HORNE; P. WEBER. SAIC. 


Mon. AM

11:00 III23 393.12 Face-specific processing continues during 

motion-induced blindness: Electrophysiological evidence. 

J. A. HARRIS*; D. L. BARACK; A. R. MCMAHON; M. G. 

WOLDORFF. Duke Univ. 

8:00 III24 393.13 � Functional neuroanatomy of face 

processing expertise: FMRI BOLD activation differences to 

personally familiar and unfamiliar faces. M. GEISHEKER; J. 

HAN; M. ADAMO; J. STILES; F. HAIST*. UCSD. 

9:00 III25 393.14 The dynamic face-unculus: Localizing the 

dynamics of facial feature encoding from MEG data. N. VAN 

RIJSBERGEN*; J. GROSS; P. G. SCHYNS. Glasgow Univ. 

10:00 III26 393.15 Task-dependent activation in the earliest 

cortical representation of diagnostic facial features. L. 

PETRO*; F. W. SMITH; P. G. SCHYNS; L. MUCKLI. Univ. of 

Glasgow. 

11:00 III27 393.16 The role of local and global configuration 

for the visual word form processing in the occipitotemporal 

cortex. C. KAO*; C. CHEN. Natl. Taiwan Univ. 

8:00 III28 393.17 Spatiotemporal brain dynamics of a two 

digit number comparison task. M. BALLAN*; R. STACKMAN, 

JR.; A. HENIK; A. FUCHS. Florida Atlantic Univ., Ben-Gurion 

Univ. of the Negev. 

9:00 III29 393.18 Different types of stimulus after the 

presentation of numbers induced different patterns of shift 

of attention toward left/right space. T. HORAGUCHI*; Y. 

YAMAKAWA; S. SASAKI. Ibaraki Prefectural Univ. of Hlth. Sci. 

10:00 III30 393.19 Is neural network for number comparison 

task shared by attention network? Y. OGATA*; T. AIKAWA; T. 

HORAGUCHI; N. WATANABE; M. YAMAMOTO. Grad. Sch. 

of Comprehensive Human Sciences, Univ. of Tsukuba, Grad. 

Sch. of Engineering, Tamagawa Univ. 

11:00 III31 393.20 Individuation of faces and orthographic 

forms - An information-based brain mapping study. A. 

NESTOR*; M. BEHRMANN; D. PLAUT. Carnegie Mellon Univ. 

8:00 III32 393.21 Neural correlates of average size 

processing. A. R. ALBRECHT*; A. NGUYEN-PHUC; T. 

VICKERY; M. M. CHUN. Yale Univ. 

9:00 III33 393.22 Feedforward emergence of perceptual 

gestalts in the human visual cortex. J. KUBILIUS*; J. 

WAGEMANS; H. P. OP DE BEECK. Univ. of Leuven (K.U. 

Leuven). 

10:00 III34 393.23 A dynamical model of perceptual grouping. 

D. MARTÍ*; J. RINZEL. Ctr. For Neural Sci. (NYU). 

11:00 III35 393.24 The all-or-none Nature of Visual Cognition: 

an MEG study of perception using short-duration visual 

symbols. K. SEKAR*; W. M. FINDLEY; A. PORRAS; J. 

GARCIA; R. LLINAS. NYU Sch. Med. 

8:00 III36 393.25 Oscillatory synchronization in large-scale 

cortical networks predicts perception. J. F. HIPP*; A. K. 

ENGEL; M. SIEGEL. Dept. Neurophys. and Pathophys., Univ. 

Med. Ctr. Hamburg, MIT. 

9:00 III37 393.26 • The surface area of human V1 correlates 

with awareness of object size. D. S. SCHWARZKOPF*; C. 

SONG; G. REES. Univ. Col. London. 

10:00 III38 393.27 Visual object recognition and masking in 

speed-of-sight tasks. J. S. GEORGE*; M. HAM; S. BARR; V. 

GINTAUTAS; C. RINAUDO; A. GUTHORMSEN; M. ANGHEL; 

P. LOXLEY; S. BRUMBY; L. BETTENCOURT; G. KENYON. 

Los Alamos Natl. Lab. 

11:00 III39 393.28 Robust classification of objects, faces, 

and flowers using natural image statistics. C. M. KANAN; G. 

COTTRELL*. UCSD. 

8:00 III40 393.29 Previous experience enhances visual 

perception: Intracranial EEG effects of familiarization on 

the processing of degraded natural images. J. ARU*; N. 

AXMACHER; A. DO LAM; J. FELL; W. SINGER; L. MELLONI. 

Max Planck Inst. For Brain Res., Frankfurt Inst. for Advanced 

Studies, Univ. of Bonn. 

9:00 III41 393.30 Statistical principles of object recognition. 

M. LI*; Z. YANG. BBDI. 

POSTER 

394. Perception and Imagery: Motion, Space, and Scenes 



8:00 III42 394.1 Dissociating perceptual hysteresis and 

adaptation in multistable dot lattices: An fMRI study. C. M. 

SCHWIEDRZIK*; F. LEITNER; W. SINGER; C. C. RUFF; L. 

MELLONI. Max Planck Inst. for Brain Res., Brain Imaging Ctr., 

Univ. of Kaiserslautern, Goethe Univ., Univ. Col. London, Univ. 

of Zürich. 

9:00 III43 394.2 Background similarity effect in visual 

adaptation: A reevaluation of null aftereffect transfer from 

second- to first-order stimuli. N. QIAN*; P. DAYAN. Columbia 

Univ., Univ. Col. London. 

10:00 III44 394.3 Spatial item identification in Parkinson’s 

disease. S. N. HALPIN*; T. L. MCISAAC. Teachers College, 


11:00 III45 394.4 Esthetic preference-independent 

engagement of reward circuitry by visual art. S. A. LACEY*; 

H. HAGTVEDT; V. PATRICK; A. ANDERSON; R. STILLA; 

G. DESHPANDE; X. HU; J. SATO; S. REDDY; K. SATHIAN. 

Emory Univ., Boston Col., Univ. of Houston, Univ. of Sao 

Paolo, Singapore Mgmt. Univ. 

8:00 III46 394.5 Processing of motion in depth and 

optic flow share a common brain area. S. VAN STIJN*; A. 

KOHLER; W. SINGER; H. S. LEE. Max Planck Inst. For Brain 

Res., Univ. Hosp. of Psychiatry, Max Planck Inst. for Brain 

Res. 

9:00 III47 394.6 Interactions between dorsal and ventral 

visual subsystems in 3-D object structure perception from 

motion. S. IWAKI*; J. W. BELLIVEAU. Natl. Inst. of Advanced 

Industrial Sci. and Technol. (AIST), Massachusetts Gen. 

Hosp. 

10:00 III48 394.7 Temporal patterns of activation during 

biological motion perception: An fMRI study. E. YAMAMOTO*; 

Y. SOMEYA; Y. SUNG; S. OGAWA; S. WATANABE. Keio 

Univ., Kansei Fukushi Res. Ctr., Tohoku Fukushi Univ. 

11:00 III49 394.8 • Do weaker motion signals enhance 

temporal motion integration? Y. TSUSHIMA*; K. SHIBATA; K. 

NAKAYAMA. Harvard Univ., Boston Univ. 

8:00 III50 394.9 Line drawings and color photographs 

elicit similar neural representations of scene categories. D. M. 

BECK*; D. B. WALTHER; B. CHAI; E. CADDIGAN; L. FEI-FEI. 

Univ. Illinois, Ohio State Univ., Stanford Univ. 

9:00 JJJ1 394.10 Visual cortex detects the amount of 

structure in novel abstract images. J. M. WHITE*; J. ZHAO; R. 

LEE; N. B. TURK-BROWNE; D. OSHERSON. Princeton Univ. 

10:00 JJJ2 394.11 Adaptation and orientation-selective 

filtering indicate the use of image statistics in rapid scene 

categorization. D. KAPING*; S. TREUE. German Primate Ctr., 

Bernstein Ctr. for Computat. Neurosci. 



11:00 JJJ3 394.12 Neural correlates of visual search in 

natural scenes. F. GUO*; K. DAS; B. GIESBRECHT; M. 

P. ECKSTEIN. Univ. of California, Santa Barbara, Inst. for 

Collaborative Biotechnologies, Univ. of California, Santa 

Barbara. 

8:00 JJJ4 394.13 A hierarchically organized cortical 

network for scene perception. J. B. JULIAN*; D. D. DILKS; 

J. KUBILIUS; S. HU; J. LIU; N. KANWISHER. MIT, Bejing 

Normal Univ. 

9:00 JJJ5 394.14 Does sleep affect the way we see 

the world around us? B. R. SHETH*; H. NGUYEN; G. 

WHITTAKER; S. B. STEVENSON. Univ. Houston. 

10:00 JJJ6 394.15 • Spatiotopic coding of BOLD signal 

in visual cortex depends on spatial attention. D. BURR*; 

S. CRESPI; L. BIAGI; M. TOSETTI; G. D’AVOSSA; M. C. 

MORRONE. Univ. of Florence, Universita’ Vita-Salute “San 

Raffaele”, Fondazione Stella Maris, Bangor Univ., Univ. of 

Pisa. 

11:00 JJJ7 394.16 The brain organization of perception in 

chess experts. D. C. KRAWCZYK*; J. C. BARTLETT; A. L. 

BOGGAN; M. M. MCCLELLAND. Univ. of Texas at Dallas. 

8:00 JJJ8 394.17 Visual evoked potentials and early 

BOLD-components modeled as “EPSP-analogs”: A mesoconductance-based 

model. J. F. GOMEZ-MOLINA*. Int Group 

of Neurosci Cra 64c #48-94(603). 

POSTER 

395. Motor and Sequence Learning 



8:00 JJJ9 395.1 Strategy switching in category learning. B. 

J. SPIERING*; A. H. GONZALEZ; C. SEGER. Colorado State 

Univ. 

9:00 JJJ10 395.2 Evidence for a rostrocaudal organization 

of the prefrontal cortex in rule representation and a 

ventrodorsal organization of the premotor cortex in rule 

automaticity. S. HELIE*; J. L. ROEDER; S. KAUFMAN; K. 

LIBAN; F. G. ASHBY. Univ. of California, Santa Barbara. 

10:00 JJJ11 395.3 Are offline leaning enhancements 

predictable? J. RHEE*; D. L. WRIGHT. Texas A&M Univ. 

11:00 JJJ12 395.4 • What can Wii Learn? A pilot study of motor 

learning in dementia. A. L. FENNEY*; T. D. LEE. McMaster 

Univ. 

8:00 JJJ13 395.5 Human reconsolidation: Processing in 

primary motor cortex during motor memory recall enables 

memory strengthening. N. CENSOR*; M. A. DIMYAN; L. G. 

COHEN. NIH. 

9:00 JJJ14 395.6 Time-resolved functional community 

detection in motor learning. D. S. BASSETT*; N. F. WYMBS; 

M. A. PORTER; P. J. MUCHA; J. M. CARLSON; S. T. 

GRAFTON. Univ. of California Santa Barbara, Univ. of Oxford, 

The Univ. of North Carolina. 

10:00 JJJ15 395.7 Motor skill consolidation following 

observation. M. TREMPE*; M. SABOURIN; H. 

ROHBANFARD; L. PROTEAU. Univ. Montréal. 

11:00 JJJ16 395.8 The influence of prior belief on 

visuomotor learning. E. J. A. TURNHAM; D. A. BRAUN; D. M. 

WOLPERT*. Univ. of Cambridge. 



8:00 JJJ17 395.9 • Process-specific dual-task interference 

enhances motor learning. H. GOH*; K. J. SULLIVAN; J. 

GORDON; C. J. WINSTEIN. USC. 

9:00 JJJ18 395.10 Vector representation of the hand in the 

mirror tracing task. J. D. CADENA-VALENCIA*; F. LÓPEZ. 

Univ. Nacional Autónoma de México. 

10:00 JJJ19 395.11 Learning without knowing: subliminal 

visual feedback facilitates ballistic motor learning. J. 

LUNDBYE-JENSEN*; C. LEUKEL; J. B. NIELSEN. Dept. of 

Neurosci. and Pharmacology, Univ. of Copenhagen, Dept. of 

Exercise and Sport Sciences, Univ. of Copenhagen, Dept. of 

Sport Science, Univ. of Freiburg, Dept. of Medicine, Unit of 

Sport Science, Univ. of Fribourg. 

11:00 JJJ20 395.12 Learning internal models for motion 

extrapolation. N. J. POWELL*; P. SCHRATER. Univ. of 

Minnesota. 

8:00 JJJ21 395.13 Single-trial classification of intracranial 

EEG during visuomotor sequence learning in humans. I. 

O. CONSTANTINESCU*; M. DE LUCIA; G. POURTOIS; 

M. SEECK; S. SCHWARTZ. Univ. of Geneva, EEG Brain 

Mapping Core, Ctr. for Biomed. Imaging of Geneva and 

Lausanne, Dept. of Exptl. clinical and health psychology, 

Geneva Univ. Hosp., Geneva Neurosci. Center, Univ. of 

Geneva, Geneva Neurosci. Ctr. Univ. of Geneva, Swiss Ctr. 

for Affective Sci. 

9:00 JJJ22 395.14 • Intermanual transfer effect in sequencial 

tapping by motor imagery. K. AMEMIYA*; S. KOJIMA; T. 

YAMASOBA. Grad. Sch. of Medicine, Univ. of Tokyo, Carls, 

GCOE, Keio Univ. 

10:00 JJJ23 395.15 Different routes to learn a procedural skill. 

S. S. SONG*; E. BUCH; A. ELLENSTEIN; L. G. COHEN. NIH/ 

NINDS, Univ. of Oxford. 

11:00 JJJ24 395.16 The effects of goal motivation on implicit 

sequence learning. J. M. LEE*; K. R. GAMBLE; J. R. SIMON; 

J. H. HOWARD, Jr; D. V. HOWARD. Georgetown Univ., The 

Catholic Univ. of America, Georgetown Univ. Med. Ctr. 

8:00 JJJ25 395.17 Callosal contributions to motor sequence 

learning. L. BONZANO*; A. TACCHINO; L. ROCCATAGLIATA; 

M. BOVE. Univ. Genoa. 

9:00 JJJ26 395.18 Linkage of white matter integrity with 

contextual interference benefits in motor sequence learning. 

P. UDOMPHOLKUL*; C. LIN; M. CHIANG; B. KNOWLTON; A. 

D. WU. UCLA. 

10:00 JJJ27 395.19 Acquisition and retention of motor 

sequences: The effects of time of the day and sleep. C. 

MOISELLO*; S. KVINT; A. D. PRUSKI; B. BASSIRI-TEHRANI; 

J. NIA; B. PERFETTI; M. GHILARDI. CCNY. 

11:00 JJJ28 395.20 Effects of a MTL-loading simultaneous 

task on implicit probabilistic motor sequence learning. K. 

R. GAMBLE*; R. A. BECKER; J. H. HOWARD, Jr; D. V. 

HOWARD. Georgetown Univ., The Catholic Univ. of America, 

Georgetown Univ. Med. Ctr. 

8:00 JJJ29 395.21 Involvement of ipsilateral and contralateral 

primary motor cortex in implicit and explicit motor sequence 

learning. A TMS study. M. BOVE*; E. PELOSIN; A. 

TACCHINO; A. GIANNINI; L. AVANZINO. Univ. of Genoa. 


Mon. AM

POSTER 

396. Long-Term Memory: Retrieval 



8:00 JJJ30 396.1 Effects of face angle on neural activity 

of the inferior temporal cortex and superior temporal sulcus 

- A 3T fMRI study in human -. T. IIDAKA*; T. HARADA; S. 

EIFUKU; R. NAKATA; R. TAMURA; N. SADATO. Nagoya 

Univ, Grad Sch. Med, Dept Psych, Univ. of Toyama, 

Grad. Sch. of Med. and Pharmaceut. Sci., Natl. Inst. for 

Physiological Sci. 

9:00 JJJ31 396.2 Differential impact of reward on item 

versus source memory. J. MACINNES*; K. E. MACDUFFIE; 

R. ADCOCK. Duke Univ. 

10:00 JJJ32 396.3 • The path to memory is guided by strategy: 

Distinct networks engaged in associative encoding under 

visual or verbal strategy. J. B. HALES*; J. B. BREWER. UC 

San Diego. 

11:00 JJJ33 396.4 • Elaboration versus suppression of cued 

memories: Influence of memory recall instruction and success 

on parietal lobe and hippocampal activity. S. I. GIMBEL*; J. B. 

BREWER. UC San Diego. 

8:00 JJJ34 396.5 Suppression of hippocampal activity and 

default network during verbal associative recall with postretrieval 

processing. E. T. SCHWAGER*; S. I. GIMBEL; J. B. 

HALES; J. B. BREWER. UC San Diego. 

9:00 JJJ35 396.6 Illuminating the dynamics of memory 

search: Tracking category-related oscillations during free 

recall. N. W. MORTON*; S. M. POLYN. Vanderbilt Univ. 

10:00 JJJ36 396.7 Using the context maintenance and 

retrieval model to interpret task-related neural activity in 

free recall. Z. D. COHEN*; N. W. MORTON; S. M. POLYN. 

Vanderbilt Univ. 

11:00 JJJ37 396.8 Reconstructing the past: BOLD differences 

between veridical and false recollection match individual 

performance in a real-life manipulated-memory task. R. 

LUDMER; Y. DUDAI*. Weizmann Inst. Sci. 

8:00 JJJ38 396.9 Top-down control during recollection and 

the influence of visual distraction: An fmri-guided rtms study. P. 

E. WAIS*; A. GAZZALEY. UC, San Francisco. 

9:00 JJJ39 396.10 Illuminating the mechanisms of control 

during selective long-term memory retrieval - a new paradigm. 

J. M. KIZILIRMAK*; F. RÖSLER; P. H. KHADER. Philipps- 

University. 

10:00 JJJ40 396.11 • Prefrontal-medial temporal lobe 

interactions supporting the cognitive control of episodic 

retrieval. J. L. BARREDO*; I. OZTEKIN; D. BADRE. Brown 

Univ. 

11:00 JJJ41 396.12 Spatially distributed activation in 

neostriatal systems corresponds to increased levels of 

semantic difficulty in response inhibition. H. CHIANG*; C. 

CALLEY; M. KRAUT; J. HART JR. The Univ. of Texas at 

Dallas, Ctr. for BrainHealth, The Johns Hopkins Sch. of Med. 

8:00 JJJ42 396.13 Accurate temporal context memory is 

associated with greater multivoxel pattern change in the 

prefrontal cortex. L. J. JENKINS*; C. RANGANATH. UC 

Davis. 

9:00 JJJ43 396.14 Neural correlates of temporal context 

retrieval. A. C. HEUSSER*; C. RANGANATH. UC-Davis. 

10:00 JJJ44 396.15 Neural correlates of repetition priming, 

recollection, and familiarity in recognition memory for words. 

J. R. TAYLOR*; L. G. BURATTO; R. N. HENSON. Med. Res. 

Council. 

11:00 JJJ45 396.16 Carry-over effects provide evidence for 

pattern separation and completion biases. K. D. DUNCAN*; V. 

SKVORTSOVA; L. DAVACHI. New York Univ. 

8:00 JJJ46 396.17 Cortical reactivation and strategic retrieval. 

S. M. TUBRIDY*; L. DAVACHI, PhD. New York Univ. 

9:00 JJJ47 396.18 An investigation of interference effects 

on associative memory consolidation. K. L. VILBERG*; L. 

DAVACHI. New York Univ. 

10:00 JJJ48 396.19 Behavioral and neural factors that account 

for individual differences of criterion shifting during recognition 

memory. E. M. AMINOFF*; S. FREEMAN; D. CLEWETT; 

C. TIPPER; A. FRITHSEN; A. JOHNSON; C. BENNETT; S. 

GRAFTON; M. MILLER. Univ. of California, Santa Barbara. 

11:00 JJJ49 396.20 Temporal pole subregions are functionally 

linked to distinct cortical networks. B. PASCUAL*; M. 

HOLLENBECK; B. C. DICKERSON. Massachusetts Gen. 

Hosp. and Harvard Med. Sch. 

8:00 JJJ50 396.21 Activity and connectivity in frontoparietal 

attentional-executive systems predict individual differences 

in episodic memory performance. L. WANG*; A. NEGREIRA; 

A. BAKKOUR; P. LAVIOLETTE; R. A. SPERLING; B. C. 

DICKERSON. Massachusetts Gen. Hosp., Brigham and 

Women’s Hosp. 

9:00 KKK1 396.22 Dissociating memory retrieval-related 

processes in networks defined from regions in human left 

lateral parietal cortex using an extended reveal paradigm. 

S. M. NELSON*; M. E. WHEELER; B. L. SCHLAGGAR; 

S. E. PETERSEN. Washington Univ. In St. Louis, Univ. of 

Pittsburgh, Washington Univ. in St. Louis. 

10:00 KKK2 396.23 Parcellation in left lateral parietal cortex is 

similar in children and adults. K. A. BARNES*; S. M. NELSON; 

A. L. COHEN; J. D. POWER; R. S. COALSON; F. M. MIEZIN; 

A. C. VOGEL; J. W. DUBIS; J. A. CHURCH; J. E. C. LIEU; S. 

E. PETERSEN; B. L. SCHLAGGAR. Washington Univ. Sch. of 

Med., Washington Univ. in St. Louis. 

11:00 KKK3 396.24 Recognition memory performance 

correlates with left-frontal, not parietal old/new ERP effects. C. 

A. MACLEOD*; D. I. DONALDSON. Univ. of Stirling. 

8:00 KKK4 396.25 The relationship between retrieval-related 

activity in left posterior parietal cortex, recollection and source 

memory confidence. S. S. YU*; J. D. JOHNSON; M. D. 

RUGG. Univ. Calif Irvine. 

9:00 KKK5 396.26 Neural correlates of list method directed 

forgetting. B. ADHIMOOLAM*; T. D. MOODY; G. CHANG; N. 

SUTHANA; E. BJORK; B. KNOWLTON. MIT, UCLA. 

10:00 KKK6 396.27 Moderate levels of memory activation lead 

to forgetting in the think/no-think paradigm. G. J. DETRE; A. 

NATARAJAN; K. NORMAN*. Princeton Univ. 

11:00 KKK7 396.28 Memory for motion and spatial location is 

mediated by non-retinotopic motion processing cortex. S. D. 

SLOTNICK*; P. P. THAKRAL. Boston Col. 

8:00 KKK8 396.29 Positive feedback and the sensitivity of 

memory consolidation and reconsolidation to protein synthesis 

or kinase inhibition: A computational study. Y. ZHANG*; P. 

SMOLEN; D. A. BAXTER; J. H. BYRNE. Univ. Texas. 



POSTER 

397. Long-Term Memory: Clinical Studies and Aging 



8:00 KKK9 397.1 Episodic distinction between past 

and future mental time travel in healthy older adults: An 

fMRI study. A. VIARD*; G. CHÉTELAT; K. LEBRETON; 

B. DESGRANGES; B. LANDEAU; V. DE LA SAYETTE; F. 

EUSTACHE; P. PIOLINO. Inserm-EPHE-Université de Caen 

U923, Univ. Paris Descartes, Inst. de Psychologie, CNRS 

UMR 8189, Lab. Psychologie et Neurosciences Cognitives. 

9:00 KKK10 397.2 ERP evidence for a ‘late correction’ 

memory retrieval strategy in older adults. K. A. WILCKENS*; 

D. A. WOLK; M. E. WHEELER. Univ. of Pittsburgh, Ctr. for the 

Neural Basis of Cognition, Univ. of Pennsylvania. 

10:00 KKK11 397.3 Pattern separation, the perforant path, 

and neurocognitive aging: A multimodal high-resolution MRI 

investigation. M. A. YASSA*; S. M. STARK; J. W. LACY; C. E. 

L. STARK. UC Irvine. 

11:00 KKK12 397.4 � Bilateral eye movement and EEG 

coherence: implications for EMDR treatment of PTSD. B. C. 

KELLER*; L. C. STEVENS. Northern Arizona Univ. 

8:00 KKK13 397.5 Influence of brain-derived neurotrophic 

factor val66met human polymorphism on declarative memory 

consolidation. L. MASCETTI*; A. FORET; L. MATARAZZO; 

V. MUTO; E. BALTEAU; C. PHILLIPS; C. DEGUELDRE; A. 

LUXEN; V. DIDEBERG; V. BOURS; P. MAQUET. Univ. De 

Liège. 

9:00 KKK14 397.6 ERP-correlates of deficient familiarity 

and recollection-based memory processes in amnestic 

mild cognitive impairment (aMCI). P. MEYER*; M. 

HOPPSTÄDTER; A. V. KING; M. WESSA; L. FRÖLICH; H. 

FLOR. Central Inst. of Mental Hlth., Saarland Univ. 

10:00 KKK15 397.7 Functional brain differences in ill-Gulf War 

veterans give rise to atypical patterns of aging in episodic 

memory. C. COOPER*; E. FARRIS; J. ARDUENGO; J. 

BARTLETT; T. ODEGARD. UT-Arlington, UTSouthwestern 

Med. Ctr., UT-Dallas. 

11:00 KKK16 397.8 Effect of thalamic stroke on recognition 

memory. G. PERGOLA*; B. KOCH; M. SCHWARZ; B. 

SUCHAN; I. DAUM. Ruhr-Universität Bochum, Dortmund 

Municipal Hosp. 

8:00 KKK17 397.9 Probabilistic classification and genetic 

risk for schizophrenia. D. WAGSHAL*; B. KNOWLTON; R. 

ASARNOW. UCLA. 

9:00 KKK18 397.10 Effects of PDE5 inhibition on cognition 

in healthy adults; an EEG study. O. A. H. RENEERKENS; 

A. SAMBETH; J. RAMAEKERS; A. BLOKLAND; H. W. M. 

STEINBUSCH; J. PRICKAERTS*. Univ. Maastricht. 

10:00 KKK19 397.11 Differences in left inferior parietal lobule 

activity during episodic memory retrieval as a function 

of APOE genotype in healthy young adults. K. ELAM; J. 

GEESEMAN; K. KERSTEIN; J. ZHU; T. WEBB; S. PARKS; J. 

HUGGENVIK; L. DILALLA; R. HABIB*. Southern Illinois Univ., 

So. Illinois Univ. Carbondale. 

11:00 KKK20 397.12 Age-related differences in wholebrain 

networks related to hippocampus head volume and 

performance in context memory encoding. D. MAILLET*; M. 

N. RAJAH. McGill Univ. 



8:00 KKK21 397.13 Reduced gray matter density in the 

memory circuit after neonatal hypoxia/ischaemia. S. 

JENTSCHKE*; M. MUNOZ; J. COOPER; T. BALDEWEG; 

D. G. GADIAN; M. DE HAAN; M. MISHKIN; F. VARGHA- 

KHADEM. UCL Inst. of Child Hlth., Natl. Inst. of Mental Hlth. 

9:00 KKK22 397.14 Fibromyalgia and visual reaction time: 

Performance improves after a month. E. MORYA*; M. 

BERTOLASSI; G. MAGNANI; A. C. VALLE; S. BOTTE; S. 

ROIZEMBLATT; F. FREGNI; P. S. BOGGIO; M. RIBERTO. 

AASDAP/IEPHSL, ICB USP, Fac. of Med. USP, Federal 

Universy of Sao Paulo, Harvard Med. Sch., Mackenzie 

Presbiterian Univ. 

10:00 KKK23 397.15 Dissociations in cognitive memory: 

Evidence from a large group with developmental amnesia and 

selective hippocampal damage. J. COOPER*; A. L. ADLAM; 

D. GADIAN; T. BALDEWEG; M. DE HAAN; M. MISHKIN; 

F. VARGHA KHADEM. UCL Inst. Child Hlth., Univ. of East 

Anglia, Natl. Inst. of Mental Hlth. 

11:00 KKK24 397.16 Developmental amnesia associated with 

severe bilateral hippocampal injury in an adolescent with 

neonatal treatment of transposition of the great arteries. T. 

MURPHY*; M. MUNOZ; J. COOPER; F. VARGHA-KHADEM. 

Univ. Col. 

8:00 KKK25 397.17 High-resolution in vivo structural imaging 

and segmentation of damaged medial temporal lobe tissue. 

D. E. WARREN*; V. MAGNOTTA; J. BRUSS; M. DUFF; D. 

RUDRAUF; M. CASSELL; D. TRANEL. Univ. of Iowa. 

9:00 KKK26 397.18 Deconstructing Henry. The neuroanatomy 

and neuroinformatics of the brain of the amnesic patient H.M. 

J. ANNESE*. The Brain Observatory. 

POSTER 

398. Long-Term Memory: Medial Temporal Lobe Studies 



8:00 KKK27 398.1 High gamma hippocampal response from 

human iEEG recordings predicts covert memory retrieval. 

M. E. CANO*; A. SHESTYUK; B. VOYTEK; A. FLINKER; P. 

M. PAZ-ALONSO; J. PARVIZI; N. E. CRONE; R. T. KNIGHT. 

Univ. of California, Berkeley, Univ. of Granada, Stanford Sch. 

of Med., Johns Hopkins Univ. Sch. of Med. 

9:00 KKK28 398.2 Prospective and retrospective retrieval of 

sequential associations of varying distance. R. S. ROSS*; K. 

R. SHERRILL; C. E. STERN. Boston Univ., Massachusetts 

Gen. Hosp. 

10:00 KKK29 398.3 Functional connectivity of the 

hippocampus and caudate during disambiguation of nonspatial 

overlapping sequences. K. R. SHERRILL; R. S. ROSS; 

C. E. STERN*. Boston Univ., Massachusetts Gen. Hosp. 

11:00 KKK30 398.4 The functional connectivity of the 

hippocampus and caudate during successful disambiguation 

of well-learned spatial sequences. T. I. BROWN*; R. S. ROSS; 

S. M. TOBYNE; C. E. STERN. Boston Univ., Massachusetts 

Gen. Hosp. 

8:00 KKK31 398.5 Genotype predicts problem solving 

performance and brain system activation. S. N. MOSES*; 

A. N. VOINESKOS; T. M. BROWN; A. M. MOSES; J. L. 

KENNEDY; B. G. POLLOCK; A. R. MCINTOSH. Hosp. 

For Sick Children, Univ. of Toronto, Baycrest Ctr., Ctr. for 

addictions and Mental Hlth. 


Mon. AM

9:00 KKK32 398.6 The medial temporal lobe supports 

conceptual implicit memory. W. WANG; M. M. LAZZARA; C. 

RANGANATH; R. T. KNIGHT; A. P. YONELINAS*. Univ. of 

California Davis, Univ. of Illinois at Chicago, Univ. of California, 

Berkeley. 

10:00 KKK33 398.7 Distinct activity in the hippocampus for 

associative and item information consolidation over time. X. 

DU*; J. YANG. Peking Univ. 

11:00 KKK34 398.8 The hippocampus in relational learning 

without conscious awareness. P. LEO*; A. J. GREENE. Univ. 

Wisconsin-Milwaukee. 

8:00 KKK35 398.9 A magnetic resonance perfusion correlate 

of dentate gyrus neurogenesis corresponds with changes in 

cognitive performance following aerobic exercise. N. DERY*; 

M. D. NOSEWORTHY; T. TOULOUSE; M. GIBALA; J. 

GILLEN; J. M. WOJTOWICZ; G. MACQUEEN; S. BECKER. 

McMaster Univ., St. Joseph’s Hosp., Univ. of Toronto, Univ. of 

Calgary. 

9:00 KKK36 398.10 Insular and hippocampal contributions 

to memory for faces with first impressions of badness. T. 

TSUKIURA*; Y. SHIGEMUNE; R. NOUCHI; T. KAMBARA; R. 

KAWASHIMA. IDAC, Tohoku Univ. 

10:00 KKK37 398.11 Dissociation of the human hippocampus 

and medial temporal lobe for spatial, associative, and 

recognition memory. N. J. GOODRICH-HUNSAKER*; T. C. 

WU; C. J. BECK; M. D. ALLEN; R. O. HOPKINS. M.I.N.D. 

Inst., Brigham Young Univ., Univ. of Florida. 

11:00 KKK38 398.12 Recollection and familiarity signals in the 

medial temporal lobe are similar when they reflect memories 

of similar strength. C. N. SMITH*; J. T. WIXTED; L. R. 

SQUIRE. UCSD, VAMC. 

8:00 KKK39 398.13 Medial temporal lobe contributions to cued 

retrieval of items and context. D. E. HANNULA*; L. A. LIBBY; 

C. RANGANATH. Univ. of Wisconsin, Univ. of California. 

9:00 KKK40 398.14 Working memory load effects in 

hippocampal subfields: A high-resolution fMRI study. K. 

SCHON*; R. E. NEWMARK; R. S. ROSS; Y. T. QUIROZ; C. E. 

STERN. Boston Univ., Massachusetts Gen. Hosp. 

10:00 KKK41 398.15 Disambiguation during working memory: 

A high-resolution investigation of the human medial temporal 

lobe. R. E. NEWMARK*; K. SCHON; R. S. ROSS; M. A. 

YOUNG; C. E. STERN. Boston Univ., Silvio O. Conte Ctr. 

for Memory and Brain, Ctr. of Excellence for Learning in 

Education, Science, and Technol., Program in Neurosci., 

Boston Univ., Dept. of Radiology, Athinoula A. Martinos Ctr. for 

Biomed. Imaging, Massachusetts Gen. Hosp. 

11:00 KKK42 398.16 High-resolution investigation of relational 

pattern separation in the medial temporal lobe using a rapid 

fMR-adaptation approach. V. A. CARR*; S. E. FAVILA; A. D. 

WAGNER. Stanford Univ. 

8:00 KKK43 398.17 Differential contributions of the 

hippocampal subfields in subsequent memory effects using 

high-resolution fMRI. J. W. LACY*; C. E. L. STARK. Univ. of 

California, Irvine. 

9:00 KKK44 398.18 Defining resting state networks within the 

human hippocampal formation using high-resolution imaging 

and functional connectivity. L. A. LIBBY*; A. D. EKSTROM; C. 

RANGANATH. Univ. of California, Univ. of California - Davis. 

10:00 KKK45 398.19 Detection of sequence violations in the 

medial temporal lobe: Subregional contributions to memorybased 

prediction through high-resolution fMRI. J. LIANG*; D. 

ZEITHAMOVA; A. R. PRESTON. Inst. Neurosci. 

11:00 KKK46 398.20 • Generalization through recurrence: An 

interactive model of the hippocampus. D. KUMARAN*; J. L. 

MCCLELLAND. Stanford Univ. 

8:00 KKK47 398.21 Memory transfer from hippocampus to 

neocortex. G. WILKEN; N. NAKAMURA*. Okinawa Inst. of 

Sci. and Technol., Okinawa Inst. Sci. Tech. IRP. 

9:00 KKK48 398.22 Hippocampal and behavioral contributions 

to recollection at short delays. C. J. BROZINSKY*; L. T. S. 

YEE; N. J. COHEN; M. D’ESPOSITO. Univ. of California 

Berkeley, Univ. of Illinois, Urbana-Champaign. 

10:00 KKK49 398.23 Nonlinear response functions related to 

memory strength are different for hippocampus and perirhinal 

cortex. Z. SONG; C. N. SMITH; L. R. SQUIRE*. UCSD, VA 

Med. Ctr. 

11:00 KKK50 398.24 Exploring multivariate patterns of neural 

activity underlying spatial perception and memory in the 

hippocampus. S. R. RUDEBECK*; K. H. BRODERSEN; A. C. 

H. LEE. Oxford Univ., Univ. of Zurich. 

8:00 KKK51 398.25 Multivoxel pattern analysis of brain activity 

in the medial temporal lobe and prediction of subsequent 

recognition performance. T. WATANABE*; S. HIROSE; 

M. KATSURA; Y. IMAI; J. CHIKAZOE; H. M. KIMURA; K. 

JIMURA; T. MACHIDA; I. SHIROUZU; Y. MIYASHITA; S. 

KONISHI. The Univ. of Tokyo, Kanto Med. Ctr. NTT EC. 

9:00 KKK52 398.26 Human analogues of rodent spatial pattern 

separation and completion memory tasks. M. PALEJA*; T. A. 

GIRARD; B. K. CHRISTENSEN. Ryerson Univ., McMaster 

Univ. 

10:00 KKK53 398.27 Dissociable neural correlates of spatial 

and temporal route representation during human spatial 

navigation. M. S. COPARA; E. A. ISHAM; W. WANG; A. 

P. YONELINAS; A. D. EKSTROM*. UC Davis, Ctr. For 

Neuroscience, UC-Davis. 

11:00 KKK54 398.28 Independent and conjunctive processing 

of spatial and temporal information in episodic memory. E. A. 

ISHAM*; M. S. COPARA; N. E. DIQUATTRO; A. CHIANG; 

D. PATEL; S. MINEYEV; B. AARONS; J. J. GENG; A. D. 

EKSTROM. Claremont Grad Univ., UC Davis. 

8:00 KKK55 398.29 Contrasting roles of hippocampus, 

parahippocampal cortex, and retrosplenial cortex in human 

spatial navigation. H. ZHANG*; A. D. EKSTROM. UC Davis. 

9:00 KKK56 398.30 Human intracranial EEG recordings 

demonstrate coordinated hippocampal and neocortical 

theta-band oscillations during episodic memory retrieval. A. 

WATROUS*; M. SEYAL; L. M. BATEMAN; T. COBB; A. D. 

EKSTROM. Univ. of California,Davis. 

POSTER 

399. Attentional Modulation 



8:00 KKK57 399.1 Enhanced attentional modulation of early 

visual processing in video game players. W. W. KHOE*; D. 

BAVELIER; S. A. HILLYARD. UCSD, Univ. of Rochester. 

9:00 KKK58 399.2 Neural basis of superior visuo-spatial 

attentional performance in video-game players. J. MISHRA*; 

M. ZINNI; D. BAVELIER; S. A. HILLYARD. UCSF, Univ. of 

California San Diego, Univ. of Rochester. 



10:00 KKK59 399.3 The saliency of attention-capturing events 

modulates the duration of exogenous attention. A. LOCHTE*; 

J. KREBS; S. TREUE. German Primate Ctr., Bernstein Ctr. for 

Computat. Neurosci. 

11:00 KKK60 399.4 Arm movement speed while counting 

aloud. B. ETNYRE*; A. ASHOORI; A. BEGER; A. CINGRANI; 

A. GONZALES; V. MARTINEZ; D. SEASTRUNK; S. 

SULTZBAUGH. Rice Univ. 

8:00 KKK61 399.5 ERP indices for influences of attentional 

factors and context regularities on target processing. P. M. 

POLLUX*; S. HALL; H. ROEBUCK; K. GUO. Univ. of Lincoln. 

9:00 KKK62 399.6 Goal-directed and stimulus-driven 

attention during natural viewing: An fMRI study. J. SALMI*; 

E. GLEREAN; L. NUMMENMAA; J. LAHNAKOSKI; I. P. 

JÄÄSKELÄINEN; J. LAMPINEN; U. ROINE; T. NIEMINEN- 

VON WENDT; P. TANI; S. LEPPÄMÄKI; P. RINTAHAKA; M. 

SAMS. Aalto Univ., Helsinki Univ. Central Hosp. 

10:00 KKK63 399.7 Attentional modulation of visual shortterm 

memory load in the intraparietal sulcus. S. TRAPP*; J. 

LEPSIEN. Max Planck Inst. For Human Cognitive and Brain 

Sci., Max Planck Inst. for Human Cognitive and Brain Sci. 

11:00 KKK64 399.8 Neural responses during visual search 

predict the magnitude of the contextual cueing effect. R. 

KASPER*; S. T. GRAFTON; B. GIESBRECHT. Univ. of 

California, Santa Barbara. 

8:00 KKK65 399.9 Spatial attention increases both accuracy 

and choice certainty in a visual motion discrimination task. 

L. ZIZLSPERGER*; T. SAUVIGNY; T. HAARMEIER. Univ. of 

Tübingen, Hertie-Institute for Clin. Brain Res. 

9:00 KKK66 399.10 • Visuospatial attention influences 

mental representation in working memory as reflected in 

the CDA. E. CLARKE*; A. ANDREWS; T. ESPESETH; R. 

PARASURAMAN; P. GREENWOOD. George Mason Univ., 

Univ. of Oslo. 

10:00 KKK67 399.11 Evidence for the supramodality of conflict 

processing: Temporal dynamics of conflict detection and 

cognitive control in an auditory Stroop task. S. E. DONOHUE*; 

M. LIOTTI; R. PEREZ, III; M. G. WOLDORFF. Duke Univ., 

Simon Fraser Univ., Univ. of Texas Hlth. Sci. Ctr. 

11:00 KKK68 399.12 Extrapolating the trajectory of an object 

during multiple-object tracking (MOT). J. Y. LIN*; W. D. 

BROMFIELD, 3rd; S. O. MURRAY, 1st; G. M. BOYNTON, 1st. 

Univ. of Washington. 

8:00 KKK69 399.13 Cortical responses to an unattended flicker 

reflect modulations in attention within and across tasks. D. A. 

BRIDWELL*; R. SRINIVASAN. Univ. of California Irvine. 

9:00 KKK70 399.14 Modulation of fusiform gyrus activity in a 

visual task-switching paradigm. H. FREY*; P. DE SANCTIS; 

M. MERCIER; J. J. FOXE. Albert Einstein Col. of Med. 

10:00 LLL1 399.15 Effect of varying stimulus-response 

mapping difficulty on reaching and saccade performance. 

M. PUISSANT*; W. E. HUDDLESTON. Univ. of Wisconsin - 

Milwaukee. 

11:00 LLL2 399.16 Neural correlates of contextual cueing in 

natural scenes. K. DAS*; F. GUO; B. GIESBRECHT; M. P. 

ECKSTEIN. Univ. of California, Santa Barbara. 

8:00 LLL3 399.17 Interactions of sustained spatial 

attention and surround suppression: An EEG study. A. 

KOSOVICHEVA*; A. N. LANDAU; M. A. SILVER. UC 

Berkeley. 



9:00 LLL4 399.18 Spatial attention modulates early face 

processing. W. FENG*; A. MARTINEZ; Y. LUO; S. A. 

HILLYARD. UCSD, State Key Lab. of Cognitive Neurosci. and 

Learning, Beijing Normal Univ. 

10:00 LLL5 399.19 Evoked oscillations, sources and ERP 

components of involuntary auditory attention in healthy adults. 

J. MOSES*; J. LIU; R. BIBI; S. BARRETT; R. MELARA. 

CCNY. 

11:00 LLL6 399.20 • Optical topography signal predicts and 

detects subjective awareness of visual changes in a change 

detection task. H. TANAKA*; T. KATURA. Advanced Res. 

Laboratory, Hitachi Ltd. 

8:00 LLL7 399.21 Overcoming the forest before the trees: 

Training the mind to detect fine grained visual details as 

quickly as global shape. S. VAN LEEUWEN*; W. SINGER; L. 

MELLONI. Max Planck Inst. For Brain Res., Goethe Univ. 

9:00 LLL8 399.22 Hemispheric chromatic VEP modulations 

of covert attention. E. J. ROTH*; J. R. HIGHSMITH; C. S. 

DUNCAN; M. A. CROGNALE. Eric Roth, Univ. of Nevada, 

Reno. 

POSTER 

400. Language: Sensorimotor Integration and Production 



8:00 LLL9 400.1 Intersubject differences in the STS 

account for variability in the perception of the McGurk effect. 

A. R. NATH*; M. S. BEAUCHAMP. Univ. of Texas Hlth. Sci. 

Ctr. at Houston. 

9:00 LLL10 400.2 fMRI-guided transcranial magnetic 

stimulation reveals that the superior temporal sulcus is a 

cortical locus of the McGurk effect. M. BEAUCHAMP*; A. 

NATH; S. PASALAR. Univ. Texas Med. Sch, Houston. 

10:00 LLL11 400.3 The effect of articulatory complexity in 

audio-visual speech perception and production: An fMRI 

study. P. TREMBLAY*; S. L. SMALL. Univ. of Chicago. 

11:00 LLL12 400.4 Neural processing of co-speech iconic 

gestures. E. H. MOK*; A. S. DICK; A. RAJA BEHARELLE; E. 

ZINCHENKO; O. E. DEMIR; S. L. SMALL. Univ. of Chicago, 

Florida Intl. Univ., Rotman Res. Inst. of Baycrest Ctr., Univ. of 

Toronto. 

8:00 LLL13 400.5 • Impairments of speech in Parkinson’s 

disease. S. ASH*; R. G. GROSS; B. MORGAN; A. BOLLER; 

A. SIDEROWF; M. GROSSMAN. Univ. Pennsylvania Sch. 

Med., Univ. of Pennsylvania Sch. of Med., Pennsylvania Hosp. 

9:00 LLL14 400.6 Learning to produce non-native speech 

sounds: An fMRI training study. A. J. SIMMONDS*; S. Y. 

DAUD; P. IVERSON; R. J. S. WISE; R. LEECH. Imperial Col. 

London, MRC Clin. Sci. Ctr., Univ. Col. London. 

10:00 LLL15 400.7 Articulation- and phonology-based codes 

in on-line processing of pseudo-words versus words. S. YOO; 

K. LEE*. Seoul Natl. Univ. 

11:00 LLL16 400.8 • Medial frontal activity during verbal 

fluency using multi-channel near-infrared spectroscopy. S. 

OBAYASHI*; S. OGAWA; Y. HARA. Nippon Med. Sch. Chiba- 

Hokusoh Hosp. 

8:00 LLL17 400.9 Electroencephalograpic analysis during 

sentence production in normal subjects. H. J. PELAYO*; V. 

ALCARAZ; D. GRANADOS; F. GARCIA. Univ. Veracruzana. 


Mon. AM

9:00 LLL18 400.10 Dissociation of electrocorticographic high 

gamma activity during word generation and word repetition 

in the ventral prefrontal cortex. K. TANJI*; M. IWASAKI; 

N. NAKASATO; H. FUNIU; K. SAKURADA; K. SUZUKI. 

Yamagata Univ., Tohoku Univ. 

10:00 LLL19 400.11 Broca’s area basal ganglia loops. A. 

A. FORD*; K. MCGREGOR; J. TRINASTIC; L. SEEDS; K. 

WHITE; B. CROSSON. Univ. of Florida, Malcom Randal VA 

Med. Ctr., McKnight Brain Inst. 

11:00 LLL20 400.12 Neurotransmitter receptor distribution and 

functional activations found in Broca’s region. M. BACHA- 

TRAMS; K. ZILLES; K. AMUNTS; A. D. FRIEDERICI*. 

Maxplanck Instit Humna Cog, Res. Ctr. Juelich, Inst. of 

Neurosci. and Med., C&O.Vogt Inst. for Brain Research, 

Heinrich Heine Univ., Univ. Hosp. Aachen. 

8:00 LLL21 400.13 Different views on haemodynamic 

signals in neocortex in response to auditory or visual word 

presentation -a method comparison of fMRI analyses-. M. 

BEU; H. HAUTZEL; C. ANTKE; H. MUELLER*. Univ. Hosp. 

Duesseldorf UKD, Univ. Dusseldorf. 

POSTER 

401. Decision Making: Basal Ganglia, Parietal Cortex, Motor 

Systems, and Learning 



8:00 LLL22 401.1 Alpha band oscillations in human 

substantia nigra. B. LEGA*; K. ZAGHLOUL; M. KAHANA. 


9:00 LLL23 401.2 Impulsive decision making after focal 

basal ganglia stroke in humans. J. WINKEL*; R. B. IVRY; 

S. D. BROWN; R. COOLS; B. U. FORSTMANN. Univ. of 

Amsterdam, Radboud Univ., Univ. of California, Univ. of 

Newcastle. 

10:00 LLL24 401.3 Altruistic punishment in patients with 

Parkinson’s disease with and without impulsive behaviour. A. 

DJAMSHIDIAN*; S. O’SULLIVAN; K. DOHERTY; A. LEES; B. 

AVERBECK. Reta Lila Weston Inst., NIMH/NIH. 

11:00 LLL25 401.4 A graded response of the human ventral 

striatum to painful gambles. A. M. BROOKS*; V. PAMMI; G. S. 

BERNS. Emory Univ., Univ. of Allahabad. 

8:00 LLL26 401.5 When men gamble, striatal oxygen 

consumption is inversely correlated with sensationseeking 

propensity. E. A. PETERSON*; A. MØLLER; P. 

BORGHAMMER; C. J. BAILEY; K. V. HANSEN; J. LINNET; A. 

GJEDDE. Copenhagen Univ., Aarhus Univ. Hosp. 

9:00 LLL27 401.6 The human substantia nigra and ventral 

tegmental area compute experiential and fictive error learning 

signals. K. D’ARDENNE*; R. MONTAGUE. Baylor Coll Med. 

10:00 LLL28 401.7 Genetic variation in striatal dopamine 

predicts D2-dependent effects of bromocriptine on cognitive 

flexibility. R. COOLS*; M. VAN HOLSTEIN; B. FRANKE; M. E. 

VAN DER SCHAAF; M. VAN SCHOUWENBURG; E. AARTS. 

Radboud Univ. Nijmegen, Donders Inst. (RU/DI-BCB). 

11:00 LLL29 401.8 Dopaminergic modulation of saliencedriven 

attentional flexibility. M. R. VAN SCHOUWENBURG*; 

H. E. DEN OUDEN; D. GEURTS; A. F. A. SCHELLEKENS; 

R. J. VERKES; B. FRANKE; J. K. BUITELAAR; R. COOLS. 

Radboud Univ. Nijmegen, Donders Inst., Radboud Univ. 

Nijmegen Med. Ctr. 

8:00 LLL30 401.9 Cortico-basal ganglia network dynamics 

during interference control and response inhibition. 

S. JAHFARI*; L. J. WALDORP; W. M. P. VAN DEN 

WILDENBERG; H. S. SCHOLTE; K. R. RIDDERINKHOF; B. 

U. FORSTMANN. Univ. of Amsterdam. 

9:00 LLL31 401.10 The value computations in vmPFC and 

the striatum are guided by visual attention. S. LIM*; J. P. 

O’DOHERTY; A. RANGEL. Caltech, Trinity Col. 

10:00 LLL32 401.11 A fronto-parietal system for dynamic 

value computations during decision making. S. WU*; J. P. 

O’DOHERTY; S. SHIMOJO; A. RANGEL. Caltech, Natl. Yang- 

Ming Univ., California Insitute of Technol. 

11:00 LLL33 401.12 Dissociating action-linked decisions from 

abstract value-based decisions in intra-parietal cortex. M. 

C. KLEIN-FLÜGGE*; T. E. BEHRENS; K. J. FRISTON; S. 

BESTMANN. Sobell Dept. of Motor Neurosci. and Movement 

Disorders, Oxford Ctr. for Functional MRI of the Brain 

(FMRIB), Wellcome Trust Ctr. for Neuroimaging. 

8:00 LLL34 401.13 A deficit in situational updating: Playing 

“rock-paper-scissors” with parietal patients. B. ANDERSON*; 

J. DANCKERT. Univ. of Waterloo. 

9:00 LLL35 401.14 Neural correlates of the distance effect for 

nonsymbolic and symbolic numerosities. L. SPRUTE*; M. M. 

GULLICK; E. TEMPLE. Dartmouth Col. 

10:00 LLL36 401.15 Tougher decisions make rougher moves: 

The kinematics of reaching to make choices during rewarded 

learning. D. A. PETERSON*; M. MULLANE; S. SAPROO; 

C. TRAN; M. YAZDANI; D. LEE; T. J. SEJNOWSKI; H. 

POIZNER. Inst. for Neural Comput, UCSD, Dept. of Cognitive 

Science, UCSD, Dept. of Psychology, UCSD, Dept. of 

Computer Sci. and Engineering, UCSD, Dept. of Electrical 

and Computer Engineering, UCSD, Howard Hughes Med. 

Institute, Salk Inst. for Biol. Studies, Div. of Biol. Sciences, 

UCSD. 

11:00 LLL37 401.16 The influence of motor cost and reward 

value in a reach foraging task. J. S. DIAMOND*; M. C. 

DORRIS; J. R. FLANAGAN. Queen’s Univ. 

POSTER 

402. Cognitive Development: Down Syndrome 


Mon. 8:00 AM – San Diego Convention Center, Halls B-H 

8:00 LLL38 402.1 A non convulsant α5-selective GABAA 

receptor inverse agonist known as a cognitive enhancer, the 

triazolophthalazine α5IA, can restore learning and memory 

functions in a mouse model of Down syndrome. M. POTIER*; 

J. BRAUDEAU; A. DUCHON; P. LOPEZ-PEREIRA; L. 

DAUPHINOT; R. H. DODD; Y. HÉRAULT; B. DELATOUR. 

CRICM CNRS Umr7225, Salpetriere Hosp., LAMC, IGBMC, 

ICS, ICSN. 

9:00 LLL39 402.2 A complet genetic model for developing 

therapeutic interventions for Down syndrome. Y. E. YU*; T. 

YU; Z. LI; Z. JIA; S. CLAPCOTE; C. LIU; S. LI; S. ASRAR; 

A. PAO; R. CHEN; N. FAN; S. CARATTINI-RIVERA; A. 

BECHARD; S. SPRING; M. HENKELMAN; G. STOICA; S. 

MATSUI; N. NOWAK; J. RODER; C. CHEN; A. BRADLEY. 

Roswell Park Cancer Inst., Univ. of Toronto, Univ. of Leeds, 

Harvard Med. Sch., Louisiana State Univ., Baylor Col. of Med., 

Texas A&M Univ., Wellcome Trust Sanger Inst. 



10:00 LLL40 402.3 The importance of sleep in designing 

clinical trials of cognition-enhancing drugs in Down syndrome. 

J. H. BRESLIN*; J. O. EDGIN; R. R. BOOTZIN; L. NADEL. 

Univ. of Arizona. 

11:00 LLL41 402.4 • APP overexpression is not sufficient to 

induce the formation of enlarged endosomes in Alzheimer 

disease and Down syndrome. J. J. LAVAUR*; J. COSSEC; 

V. DESESTRET; D. BERMAN; A. LAQUERRIERE; M. 

LECOURTOIS; A. HOISCHEN; S. STORA; C. RIPPOLL; C. 

MIRCHER; Y. GRATTEAU; S. ANTONARAKIS; J. VELTMAN; 

J. DELABAR; G. DI PAOLO; C. DUYCKAERTS; M. POTIER. 

CRICM CNRS Umr7225, Salpêtrière Hosp., Taub Inst. for 

Res. on Alzheimer’s Dis., Neuropathologie, Dept. of Human 

Genet., Inst. Jérôme Lejeune, BFA, CNRS EAC 7059. 

8:00 LLL42 402.5 Advances in neurocognitive assessment 

in intellectual disabilities: Lessons from down syndrome. J. O. 

EDGIN*; L. NADEL. Univ. Arizona. 

9:00 LLL43 402.6 PGT improves learning and synaptic 

plasticity markers in Ts65Dn mouse model of Down syndrome. 

J. M. DELABAR*; F. GUEDJ; S. LUILLIER; A. DUCHON; E. 

PALY; J. BIZOT; N. CREAU; Y. HERAULT. Univ. Paris Diderot- 

CNRS, Key-Obs Lab., ICS-IGBMC, Univ. Strasbourg. 

10:00 LLL44 402.7 CA1 neuronal ensembles become 

unstable with repeated training in the Ts65Dn mice a model of 

Down syndrome. C. L. SMITH-HICKS*; P. CAI; R. REEVES; 

P. WORLEY. Johns Hopkins Univ., Sichuan Univ. 

11:00 LLL45 402.8 Executive function in Down syndrome: 

Cognitive and genetic correlates. G. SPANO*; J. EDGIN; G. 

MASON; L. NADEL. The Univ. of Arizona. 

8:00 LLL46 402.9 Genetic contributions to executive function 

and ADHD symptom variation among individuals with Down 

syndrome. G. M. MASON*; J. O. EDGIN; L. NADEL. Univ. of 

Arizona. 

9:00 LLL47 402.10 Development of cognitive control in 

children with chromosome 22q11.2 deletion syndrome. Y. 

TAKARAE*; M. CABARAL; F. TASSONE; J. STODDARD; T. 

SIMON. Univ. of California, Davis. 

10:00 LLL48 402.11 Neural correlates of cognitive control in 

children with autism. T. VAN RAALTEN*; J. VAN BELLE; D. 

BOS; M. LANGEN; S. DURSTON. Rudolf Magnus Inst. of 

Neurosci. 

11:00 LLL49 402.12 Effects of methylphenidate on functional 

network connectivity differ by DAT1 in children with 

ADHD. L. M. PEPE*; E. M. GORDON; J. FOSS-FEIG; M. 

STOLLSTORFF; L. KENEALY; W. D. GAILLARD; M. STEIN; 

E. H. COOK; C. J. VAIDYA. Georgetown Univ., Children’s 

Natl. Med. Ctr., Univ. of Illinois. 

8:00 LLL50 402.13 Differential relations between functional 

and structural thalamocortical connectivity across 

development. D. R. BATHULA*; D. A. FAIR; K. L. MILLS; T. 

G. COSTA DIAS; M. S. BLYTHE; J. T. NIGG; B. J. NAGEL. 

Oregon Hlth. & Sci. Univ. 

9:00 LLL51 402.14 � Atypical thalamocortical connectivity 

in ADHD youth. K. L. MILLS*; T. G. COSTA DIAS; M. S. 

BLYTHE; D. BATHULA; C. IRVINE; B. L. THURLOW; R. 

BRUNO; C. A. STEVENS; J. POSNER; B. J. NAGEL; J. T. 

NIGG; D. A. FAIR. Oregon Hlth. & Sci. Univ., Columbia Col. of 

Physicians and Surgeons, New York State Psychiatric Inst. 

10:00 LLL52 402.15 The impact of immune reconstitution 

on cognitive functions of Nigerians with HIV/AIDS. A. O. 

OGUNRIN*; Y. O. OBIABO. Neurol. Unit, Med. Dept, Univ. of 

Benin, Univ. of Benin Teaching Hosp. 



11:00 LLL53 402.16 Persisting neuropsychological deficits 

in adolescents following a sport-related concussion. A. 

BAILLARGEON*; M. LASSONDE; D. ELLEMBERG. Dépt. 

Psychologie, Univ. Montréal, Ctr. de Recherche de l’Hôpital 

Ste-Justine, Ctr. de Recherche en Neuropsychologie et 

Cognition, Dépt.kinésiologie. 

8:00 LLL54 402.17 The effects of childhood trauma on EEG 

activity during a go-no-go task. F. HOWELLS*; D. STEIN; V. 

RUSSELL. Univ. Cape Town. 

9:00 LLL55 402.18 Outcome in children and adolescents 

with perinatal stroke: Functional independence, adaptive 

behaviors, and problem behaviors. A. O. BALLANTYNE*; A. 

M. SPILKIN; D. A. TRAUNER. UCSD. 

10:00 LLL56 402.19 Correcting cerebellar morphology 

improves spatial learning in Ts65Dn, a mouse model of Down 

Syndrome. I. DAS; R. H. REEVES*. Johns Hopkins Sch. of 

Med. 

POSTER 

403. Social Cognition: Judgment and Attribution 



8:00 LLL57 403.1 Neurodevelopment of moral sensitivity 

- The relative contribution of emotion and cognition. K. J. 

MICHALSKA*; J. DECETY. The Univ. of Chicago. 

9:00 LLL58 403.2 • Serotonin modulates human moral 

judgment and behavior. M. CROCKETT*; L. CLARK; M. 

HAUSER; T. ROBBINS. Dept of Exptl. Psychology, Univ. of 

Cambridge, Harvard Univ. 

10:00 LLL59 403.3 Vasopressin effects on the neural 

correlates of social recognition. C. F. ZINK*; L. KEMPF; S. 

HAKIMI; J. L. STEIN; A. MEYER-LINDENBERG. NIMH NIH, 

CalTech, UCLA, Central Inst. of Mental Hlth. 

11:00 LLL60 403.4 Effects of intranasal oxytocin 

administration on behavioral and neural responses in a multiround 

dictator game. M. J. WISTUBA*; K. MCCURRY; L. 

STRATHEARN; B. KING-CASAS. Baylor Col. Med., Texas 

Children’s Hosp., Michael E. DeBakey Veterans Affairs Med. 

Ctr. 

8:00 LLL61 403.5 A correlation between mu suppression and 

personal distress in males. R. DAUT; C. C. WOODRUFF*. 

Northern Arizona Univ. 

9:00 LLL62 403.6 • Insensitivity to rejection in the ultimatum 

game: evidence from frontotemporal dementia. K. 

RASCOVSKY*; C. T. MCMILLAN; P. MOORE; R. CLARK; B. 

MORGAN; M. GROSSMAN. Univ. of Pennsylvania Med. Ctr. 

10:00 LLL63 403.7 Immune regulation and the role of Von 

Economo neurons and fork cells in human frontoinsular and 

anterior cingulate cortex. N. A. TETREAULT*; A. Y. HAKEEM; 

C. D. STIMPSON; B. JACOBS; C. C. SHERWOOD; J. M. 

ALLMAN. Caltech, The George Washington Univ., The 

Colorado Col. 

11:00 LLL64 403.8 So funny I forgot to laugh: The neural 

correlates of cognitive humour processing. M. G. WALLACE; 

D. W. CAMPBELL*; M. MODIRROUSTA; J. SAREEN; J. O. 

POLIMENI; N. A. MCKEEN; J. P. REISS. Univ. of Manitoba, 

Cancer Care Manitoba, Univ. of Western Ontario. 

8:00 LLL65 403.9 Group foraging task reveals neural 

substrates of social influence. D. TOMLIN*; A. NEDIC; D. A. 

PRENTICE; P. HOLMES; J. D. COHEN. Princeton Univ. 


Mon. AM

9:00 LLL66 403.10 The experimental induction of autoscopic 

phenomenon with virtual reality. K. SUZUKI*; S. WAKISAKA; 

N. FUJII. Labratory For Adaptive Intelligence, RIKEN-BSI, 

Labratory For Dynamics of Emergent Intelligence, RIKEN-BSI. 

10:00 LLL67 403.11 � Affective prosody comprehension in mild 

cognitive impairment. C. L. SWALLOWS; J. JANOWITZ; M. K. 

CRANE; J. H. DOUGHERTY*. Univ. of TN Med. Ctr. 

11:00 LLL68 403.12 Distinguishing intentionality from animacy 

in the posterior superior temporal sulcus. T. GAO; B. J. 

SCHOLL; G. MCCARTHY*. Yale Univ. 

8:00 LLL69 403.13 Synchrotron-based x-ray fluorescence 

imaging of biologically-relevant metals in Williams syndrome. 

A. LAM*; E. L. OHAYON; S. M. WEBB; U. BELLUGI; K. 

SEMENDEFERI. Salk Inst. For Biol. Studies, Univ. of 

California San Diego, Stanford Synchrotron Radiation 

Lightsource. 

9:00 LLL70 403.14 A neurocomputational model relating 

brain density to neural dynamics in social cognition. E. L. 

OHAYON*; A. LAM; K. SEMENDEFERI; T. J. SEJNOWSKI; 

U. BELLUGI. The Salk Institute, CNL, The Salk Institute, LCN, 

UCSD. 

10:00 MMM1 403.15 Neural correlates of preference change 

and cognitive dissonance. K. IZUMA*; M. MATSUMOTO; K. 

MURAYAMA; K. SAMEJIMA; N. SADATO; K. MATSUMOTO. 

Caltech, Tamagawa Univ., Univ. of Munich, Natl. Inst. for 

Physiological Sci. 

POSTER 

404. Learning and Memory Systems: Midbrain and frontal 

Cortex 



8:00 MMM2 404.1 A computational model of the role of 

orbitofrontal cortex and ventral striatum in signalling reward 

expectancy in reinforcement learning. R. C. WILSON; Y. 

K. TAKAHASHI; M. R. ROESCH; T. A. STALNAKER*; G. 

SCHOENBAUM; Y. NIV. Princeton Univ., Univ. of Maryland 

Sch. of Med. 

9:00 MMM3 404.2 Orbitofrontal cortex is required for 

expectancy-related changes in phasic firing of midbrain 

dopamine neurons. Y. K. TAKAHASHI*; M. R. ROESCH; 

R. WILSON; Y. NIV; K. TORESON; P. O’DONNELL; G. 

SCHOENBAUM. Univ. Maryland, Univ. of Maryland Col. Park, 

Princeton Univ., Univ. of Maryland Sch. of Med. 

10:00 MMM4 404.3 Orbitofrontal cortex stimulation inhibits 

dopamine neurons in the ventral tegmental area: Role of 

the rostromedial tegmental nucleus (RMTg) and nucleus 

accumbens. K. L. TORESON*; G. SCHOENBAUM; P. 

SHEPARD; P. O’DONNELL. Univ. of Maryland, Baltimore. 

11:00 MMM5 404.4 Involvement of the muscarinic receptors in 

the dorsal striatum in response learning. J. C. SOARES*; T. L. 

FERREIRA; M. G. M. OLIVEIRA. Univ. Federal de São Paulo, 

Univ. Federal do ABC. 

8:00 MMM6 404.5 Disctinct contribution of the striatum 

and cerebellum to cognitive flexibility. N. EL MASSIOUI*; C. 

BORGA; F. SCHENK. Paris Sud Univ., Inst. de Psychologie. 

9:00 MMM7 404.6 Estradiol enhances amphetamine-induced 

dopamine release in the dorsal striatum in nulliparous female 

rats: A lateralized effect. D. HUSSAIN*; M. COSSETTE; B. 

WOODSIDE; W. BRAKE. Concordia Univ. 

10:00 MMM8 404.7 Dorsolateral striatal lesions impair 

long-term retention of habit memory. K. LEONG*; J. S. 

MCGARVEY; M. G. PACKARD. Texas A&M Univ. 

11:00 MMM9 404.8 Dorsolateral striatal lesions selectively 

impair the acquisition of response learning in a plus maze. J. 

S. MCGARVEY*; K. LEONG; M. G. PACKARD. Texas A & M 

Univ. 

8:00 MMM10 404.9 Competition between hippocampal and 

striatal memory systems in a rat model of normal cognitive 

aging. I. T. PEREIRA*; M. GALLAGHER; P. R. RAPP. Natl. 

Inst. On Aging, NIH, Mount Sinai Sch. of Med., Johns Hopkins 

Univ. 

9:00 MMM11 404.10 Towards a new definition of memory 

systems: Cooperation between hippocampus and dorsomedial 

striatum during spatial navigation. C. FOUQUET*; C. TOBIN; 

B. BABAYAN; B. BONTEMPI; L. RONDI-REIG. Lab. of 

Neurobio. of Adaptative Process CNRS-UPMC, Ctr. de 

Neurosciences Intégrative et Cognitives, UMR5228, CNRS- 

Université de Bordeaux 1 et 2. 

10:00 MMM12 404.11 Effect of dopamine depletion on the 

building of cognitive maps : A pilot radiotelemetric approach 

in the rodent. A. RETAILLEAU*; S. KOULCHITSKY; X. 

LEINEKUGEL; C. DEJEAN; T. BORAUD. CNRS UMR 5228. 

11:00 MMM13 404.12 Estrogen disruption of fear inhibition may 

involve down-regulation of the 5-HT6 receptor in the striatum 

and the bed nucleus of the stria terminalis in female rats. O. 

LIPATOVA*; V. MAY; D. J. TOUFEXIS. Univ. Vermont. 

8:00 MMM14 404.13 Afferent projections to the paraventricular 

nucleus of the dorsal midline thalamus. J. M. MENZIE*; W. B. 

HOOVER; R. P. VERTES. Florida Atlantic Univ. 

9:00 MMM15 404.14 Behavioural and physiological contribution 

of striatum, hippocampus and prefrontal cortex to different 

phases of spatial learning. I. GANTOIS*; A. LAEREMANS; 

V. SABANOV; T. AHMED; E. ISCRU; D. WOOLLEY; S. 

SWINNEN; N. WENDEROTH; D. BALSCHUN; L. ARCKENS; 

R. D’HOOGE. K.U. Leuven, K.U.Leuven. 

10:00 MMM16 404.15 Correlations between nucleus accumbens 

D1 dopamine receptor mRNA quantities and Morris water 

maze working memory and spatial learning in rats. D. J. 

BURDETT*; L. N. SMITH; J. M. FLINN; S. E. BACHUS. 

George Mason Univ., Univ. of Texas Southwestern Med. Ctr. 

11:00 MMM17 404.16 Increased serotonin turnover in the frontal 

cortex by dehydroepiandrosterone is monoamine oxidaseindependent. 

I. PEREZ-NERI*; C. RÍOS. Natl. Inst. Neurol. 

Neurosurg. 

8:00 MMM18 404.17 The contribution of orbitofrontal cortex 

to complex spatial behavior: Beyond reversals. J. S. 

RICEBERG*; M. L. SHAPIRO. Mount Sinai Sch. of Med. 

9:00 MMM19 404.18 Neural activity in orbitofrontal cortex 

reflects a real-time estimate of rats’ expectations for reward. 

R. Z. HANEY; Y. K. TAKAHASHI; F. LUCANTONIO; G. 

SCHOENBAUM*. Univ. of Maryland Sch. of Med., Univ. 

Maryland Schl Med. 

10:00 MMM20 404.19 Neural correlates of observational learning 

in the macaque monkey. A. BELMALIH; D. THURA; F. 

ISBAINE; A. BROVELLI; M. DEMOLLIENS; M. L. MEUNIER*; 

D. BOUSSAOUD. Inst. de Neurosciences Cognitives de la 

Méditerranée (INCM), CNRS & Aix-Marseille Univ., INSERM. 



POSTER 

405. Learning and Memory Systems: Neuronal Mechanisms 



8:00 MMM21 405.1 Place and direction-related neuronal 

activity in the monkey hippocampal formation and 

parahippocampal gyrus in a virtual reality navigation task. C. 

A. VILLAS-BOAS*; Y. FURUYA; E. HORI; J. MATSUMOTO; T. 

ONO; H. NISHIJO. Univ. of Toyama, CREST, JST. 

9:00 MMM22 405.2 Neuronal population encoding of auditory 

recognition memory within the primate temporal polar cortex. 

C. NG*; B. PLAKKE; R. OPHEIM; A. POREMBA. Univ. Iowa. 

10:00 MMM23 405.3 Anterior cingulate cortex neurons reflect 

prior experience. A. P. WEIBLE*; C. MONAGHAN; D. C. 

ROWLAND; C. G. KENTROS. Univ. Oregon. 

11:00 MMM24 405.4 A functional link between the cerebellum 

and the hippocampus relevant to spatial navigation. C. 

ROCHEFORT; A. ARABO; M. ANDRÉ; E. SAVE; L. RONDI- 

REIG*. CNRS-UPMC, CNRS-Université de Provence. 

8:00 MMM25 405.5 Local field potential activity in monkey 

dorsal temporal pole during auditory delayed matching-tosample. 

J. BIGELOW*; C. NG; A. POREMBA. Univ. of Iowa. 

9:00 MMM26 405.6 Task-related neuronal activity in primate 

primary auditory cortex during auditory delayed matchingto-sample 

performance. R. OPHEIM*; B. PLAKKE; A. 

POREMBA. Univ. Iowa. 

10:00 MMM27 405.7 morpho metric description of von-economo 

type neurons in Indian green ring neck parrot (pssitacula 

kremari) and budgerigar (melopsittacus undulates). S. 

SRIVASTAVA*; S. SHRIVASTAVA. Govt. Degree Col., Govt 

Degree Col. 

11:00 MMM28 405.8 Entorhinal cortex stellate neurons support 

computation by interference between synaptic responses. P. 

D. DODSON*; J. T. DUDMAN; M. F. NOLAN. Univ. Edinburgh, 

Howard Hughes Med. Inst. 

8:00 MMM29 405.9 Adult born granular neurons may stop 

responding after they are 1 year old. C. J. SANDOVAL*; P. 

C. BELLO-MEDINA; J. C. MENDEZ-NUNEZ; V. RAMÍREZ- 

AMAYA. UNAM INB, Inst. de Neurobiologia UNAM, Instituo de 

Neurobiologia UNAM. 

9:00 MMM30 405.10 • Expression of Arc and phosphorylation 

of CREB in the same cortical neurons after reactivation of 

a spatial exploration task. E. A. MORALES*; V. RAMIREZ- 

AMAYA. Inst. de Neurobiología, Univ. Nacional Autónoma de 

México. 

10:00 MMM31 405.11 Lateral internal medullary lamina lesions 

disrupt retrograde and anterograde object-recognition memory 

in rats. A. P. ARVANITIDIS*; M. TARDIF; D. BYKADOROVA; 

D. G. MUMBY. Concordia Univ. 

11:00 MMM32 405.12 Characterization of hippocampal 

CA3 place cell properties in the absence of mossy 

fiber transmission. S. RENAUDINEAU*; D. L. BUHL; T. 

NAKASHIBA; T. J. MCHUGH; S. TONEGAWA. The Picower 

Inst. For Learning and Memory, MIT. 

8:00 MMM33 405.13 • An identified circuit in rat postrhinal 

cortex contains some of the essential information for 

performing specific visual shape discriminations. G. ZHANG*; 

H. CAO; L. KONG; J. O’BRIEN; A. BAUGHNS; M. JAN; X. 

WANG; X. LU; R. G. COOK; A. I. GELLER. West Roxbury 

VA Hospital/Harvard Med. Sch., west Roxbury VA Hospital/ 

Harvard Med. Sch., tufts Univ. 



9:00 MMM34 405.14 Mossy fiber input for pattern separation 

and pattern completion. T. NAKASHIBA*; J. CUSHMAN; K. A. 

PELKEY; C. J. MCBAIN; M. S. FANSELOW; S. TONEGAWA. 

The RIKEN-MIT Ctr. For Neural Circuit Genetics, The Picower 

Inst. For Lear, Dept. of Psychology, UCLA, NICHD, NIH. 

10:00 MMM35 405.15 • A possible mechanism of low liability of 

lurasidone for memory impairment in the passive-avoidance 

test in medication naïve rats: Low binding affinity for 

adrenergic alpha1 receptors? H. EMOTO; H. NISHIKAWA; 

T. HORISAWA; S. TOMA; M. GOTO; T. MURAI; K. IKEDA; T. 

ISHIYAMA; M. TAIJI*. Dainipppon Sumitomo Pharma Co., Ltd. 

11:00 MMM36 405.16 Cells of the dentate gyrus polymorphic 

layer have spatial firing with multiple, irregularly distributed 

fields. J. P. NEUNUEBEL; J. L. JOHNSON; J. J. KNIERIM*. 

Johns Hopkins Univ., Univ. of Texas Grad. Sch. of Biomed. 

Sci., Univ. of Texas Med. Sch. at Houston. 

8:00 MMM37 405.17 Evidence that hilar mossy cells of the 

dentate gyrus are novelty detectors. M. J. SCHANER; A. M. 

DUFFY; A. POVEDA; H. E. SCHARFMAN*. Nathan Kline 

Inst., New York Univ. Langone Med. Ctr. 

9:00 MMM38 405.18 Neuroplasticity underlying enhanced 

cognition following paternal experience in Peromyscus 

californicus. C. L. FRANSSEN*; J. E. HAMPTON; M. BARDI; 

E. A. SHEA; J. HUBER; A. P. RHONE; R. A. FRANSSEN; M. 

M. HYER; K. G. LAMBERT. Randolph-Macon Col., Marshall 

Univ., Longwood Univ., Bucknell Univ. 

10:00 MMM39 405.19 Repeated exposure of the developing rat 

brain to MRI did not affect neurogenesis, cell death or memory 

function. C. ZHU*; J. GAO; Q. LI; Z. HUANG; Y. ZHANG; H. 

LI; K. BLOMGREN. Ctr. For Brain Repair & Rehabil., The 

Third Affiliated Hosp. of Zhengzhou Univ. 

11:00 MMM40 405.20 Molecular genetic studies of the role of 

TrkB signaling in hippocampal learning and memory. C. J. 

CREGO*; Y. LEE; A. J. SILVA. UCLA. 

8:00 MMM41 405.21 Experience-dependent changes in cellular 

retinol-binding protein 1 expression in neurogenic regions of 

squirrel monkey brain. A. G. LEE*; D. M. LYONS. Stanford 

Univ. 

9:00 MMM42 405.22 Empathy fear in the mouse involves 

affective pain system and Ca v 1.2 Ca 2+ channels in the anterior 

cingulate cortex. H. SHIN*; D. JEON; S. KIM; M. CHETANA; 

H. RULEY; J. KINET; S. LIN; D. RABAH; D. JO. Korea Inst. 

Sci. & Tech., Vanderbilt Univ. Schl of Med, Nashville, USA, 

Beth Israel Deaconess Med. Ctr. and Harvard Med. Schl, 

ProCell Therapeutics, Inc. 

10:00 MMM43 405.23 Impairment of long-term memory by 

halogenated thymidine analogues in mice. K. ANOKHIN*; O. I. 

IVASHKINA; D. V. BEZRIADNOV. Inst. of Normal Physiol. 

11:00 MMM44 405.24 • NMDA- and AMPA receptor-dependent 

improvement of learning and memory by steviol. M. 

MOHAJERI*; A. WYSS; J. PIUSSI; H. RIEGER; N. SEIFERT; 

R. GORALCZYK; A. A. MECHAN. DSM Nutritional Prod. 

8:00 MMM45 405.25 Possible registration of olfactory events 

during general anesthesia. A. R. SAMUELSSON*; N. R. 

BRANDON; Y. XU. Univ. of Pittsburgh Sch. of Med. 

9:00 MMM46 405.26 • HDAC3 is a critical negative regulator 

of long-term memory formation. S. C. MCQUOWN*; R. M. 

BARRETT; R. J. POST; T. ALENGHAT; S. E. MULLICAN; 

S. JONES; J. RUSCHE; M. A. LAZAR; M. A. WOOD. Univ. 

California-Irvine, Univ. of Pennsylvania, Repligen Corp. 


Mon. AM

10:00 MMM47 405.27 • Heterotypic gap junctions between 

two mushroom body modulatory neurons are necessary for 

Drosophila memory formation. M. M. SHIH*, ESQ; C. WU; J. 

S. LAI; H. YANG; G. TURNER; L. CHEN; A. CHIANG. NTHU, 

Brain Res. Ctr., Mol. Med., Cold Spring Harbor. 

11:00 MMM48 405.28 The 5-HT 6 receptor antagonist, Lu 

AE58054 blocks the effect of 5-HT 6 receptor-stimulated 

modulation of extracellular neurotransmitter levels in the 

medial prefrontal cortex of rats. A. MORK*; J. J. KARLSSON; 

J. ARNT. H. Lundbeck A/S. 

POSTER 

406. Memory Consolidation and Reconsolidation: Molecular 

Mechanisms II 



8:00 MMM49 406.1 • Individual EEG pattern after repetitive 

restraint stress correlates with hippocampal mGluR5 

expression in rats. Y. YEONG SHIN*; G. KIM; C. KIM; D. KIM. 

Yonsei univ. col. of medicine, Brain Korea 21 Project for Med. 

Sci. 

9:00 MMM50 406.2 • Roles of calcineurin in hippocampus and 

amygdala in reconsolidation and extinction of contextual fear 

memory. R. KIM*; K. NADER; S. KIDA. Tokyo Univ. Agr., JST. 

CREST, McGill Univ. 

10:00 MMM51 406.3 Carbon dioxide and acidosis increase fear 

memory consolidation through ASIC1a. A. M. WUNSCH*; J. 

E. ALLEN; K. ZENNER; J. A. WEMMIE. Univ. Iowa. 

11:00 MMM52 406.4 Off-line reactivation of glutamate and 

norepinephrine in the amygdala is involved in aversive 

taste memory consolidation. K. R. GUZMAN-RAMOS*; D. 

OSORIO-GÓMEZ; F. BERMÚDEZ-RATTONI. UNAM IFC. 

8:00 MMM53 406.5 Combining an enzymatic assay and 

a targeted proteomics approach to study the role of the 

ubiquitin proteasome system in learning and memory. A. M. 

BRUNNER*; R. Y. TWEEDIE-CULLEN; E. LACZKO; I. M. 

MANSUY. Brain Res. Inst. ETHZ/UZH, Functional Genomics 

Ctr. Zurich ETHZ/UZH. 

9:00 MMM54 406.6 • CREB regulates memory performance 

though expression regulation of BDNF. H. FUKUSHIMA*; T. 

MUKAWA; A. SUZUKI; E. OKANO; K. ENDO; S. KIDA. Tokyo 

Univ. Agri, JST. CREST. 

10:00 MMM55 406.7 Impairment of memory reconsolidation 

initiates two stages of amnesia: Independent and dependent 

on repeated learning or NMDA glutamate receptor agonist 

application. S. V. SOLNCEVA*; V. P. NIKITIN; A. V. 

SHEVELKIN; V. V. SHERSTNEV. P.K.Anokhin Inst. Norm 

Physiol. 

11:00 MMM56 406.8 The role of Npas4 in hippocampal 

function. K. RAMAMOORTHI*; K. SEKI; R. FRENCH; G. 

BELFORT; Y. LIN. MIT. 

8:00 MMM57 406.9 An mGluR2/3 negative allosteric 

modulator improves recognition memory assessed by natural 

forgetting in the novel object recognition test in the rat. M. 

KALINICHEV*; B. CAMPO; N. LAMBENG; S. CÉLANIRE; M. 

SCHNEIDER; A. BESSIF; I. ROYER-URIOS; B. MINGARD; 

F. PASTOR; D. PARRON; N. MAHIOUS; F. GIRARD; E. LE 

POUL. Addex Pharmaceuticals SAS, Addex Pharma S.A. 

9:00 MMM58 406.10 Chromatin dynamics in motor skill 

learning. P. FERREIRA*; R. M. COSTA. Champalimaud 

Neurosci. Program At Inst. Gulbenkian De Ciência, Oeiras, 

Po. 

10:00 MMM59 406.11 Curcumin improves neurological 

recovery and spatial memory after cerebral ischemia in 

rats. A. JIMENEZ-ANGUIANO*; J. GORDILLO-RUIZ; L. 

LEON-VAZQUEZ; Y. CRUZ-MARTINEZ; J. VELAZQUEZ- 

MOCTEZUMA. Univ. Autónoma Metropolitana. 

11:00 MMM60 406.12 Change of acetylcholine in hippocampus 

in operant conditioning improved by swimming. L. ZHENG*; 

Q. DENG; R. YIMITI; K. LIU*. Capital Inst. of Physical Educ., 

Third Military Med. Univ. 

8:00 MMM61 406.13 Dopamine D1 receptor activation in the 

prelimbic cortex transiently blocks the recall of both rewarding 

and aversive emotional associative memories. N. LAUZON*; 

M. BECHARD; S. R. LAVIOLETTE. Univ. Western Ontario. 

9:00 MMM62 406.14 Histone deacetylase activity in the 

hippocampus modulates long-term memory in a CBPdependent 

manner. J. HAETTIG*; D. P. STEFANKO; M. L. 

MULTANI; D. X. FIGUEROA; M. A. WOOD. Univ. of California, 

Irvine. 

10:00 MMM63 406.15 Arc anti-sense in primary auditory cortex 

blocks perceptual learning. E. CARPENTER-HYLAND*; K. 

BUNTING; D. BLAKE; A. VAZDARJANOVA. Med. Col. of GA, 


11:00 MMM64 406.16 Differences in the effects of dorsal and 

ventral hippocampal nicotine infusion on learning. J. W. 

KENNEY*; J. D. RAYBUCK; T. J. GOULD. Temple Univ., 

Oregon Hlth. Sci. Univ. 

8:00 MMM65 406.17 � The DBA/2J strain of mouse 

demonstrates deficits in foreground and background fear 

conditioning but not transitive inference compared to the 

C57BL/6J strain. K. A. CORDERO*; J. M. ANDRÉ; T. J. 

GOULD. Temple Univ. 

9:00 MMM66 406.18 The effects of nicotine on long-term and 

short-term memory. D. WILKINSON*; J. ANDRE; T. GOULD. 

Temple Univ. 

10:00 MMM67 406.19 Inactivation of the dorsal hippocampus 

leads to deficits in the transitive inference task in C57BL/6 

mice. J. M. ANDRE*; K. A. CORDERO; T. J. GOULD. Temple 

Univ. 

11:00 MMM68 406.20 Cannabinoid effects on object recognition 

memory depend on training-associated emotional arousal. 

P. CAMPOLONGO*; S. SCACCIANOCE; V. TREZZA; P. 

RATANO; D. HAUER; G. SCHELLING; J. MCGAUGH; 

V. CUOMO; B. ROOZENDAAL. Sapienza Univ. of Rome 

Dept. Physiol. and Pharmacol., Univ. “RomaTre”, Ludwig 

Maximilians Univ., Univ. of California Irvine, Univ. Med. Ctr. 

Groningen. 

8:00 MMM69 406.21 Translating synaptic tagging to behavior: 

Weak spatial memory consolidates when paired to protein 

synthesis inducing novelty exploration. R. L. REDONDO*; S. 

WANG; R. G. M. MORRIS. Univ. of Edinburgh. 

9:00 MMM70 406.22 Valence dependent asymmetric release of 

norepinephrine in the basolateral amygdala. E. J. YOUNG*; 

C. L. WILLIAMS. Univ. Virginia. 

10:00 MMM71 406.23 Non-alcoholic fatty liver disease 

potentiates the effects of epinephrine on blood glucose levels. 

A. P. ROSS*; J. N. DARLING; M. B. PARENT. Georgia State 

Univ. 



11:00 MMM72 406.24 • Pro-cognitive effects of Fasudil in 

aged rats. T. DITTGEN*; C. PLAAS; E. HANDWERKER; 

C. PITZER; R. SPOELGEN; F. KIRSCH; O. WAFZIG; K. 

NIKOLICH; A. SCHNEIDER. SYGNIS Biosci. GmbH & Co 

KG, Amnestix Inc. 

POSTER 

407. Memory Consolidation and Reconsolidation: Molecular 

Mechanisms I 



8:00 MMM73 407.1 Loss of the alpha isoform of the A-kinase 

anchoring protein gravin impairs β2 adrenergic receptor 

mediated hippocampal synaptic plasticity and memory. R. 

HAVEKES*; T. HUANG; T. NIE; A. PARK; L. GUERCIO; J. 

HAWK; J. WASSERMAN; B. ACAR; Q. GRIMES; T. ABEL. 


9:00 MMM74 407.2 Assembly sequences support the 

modification of synaptic weight. P. B. KRUSKAL*; J. M. 

KIMMEL; J. N. MACLEAN. Univ. of Chicago. 

10:00 NNN1 407.3 Hippocampal BDNF expression is required 

for the enhancement of memory consolidation induced by 

GABA A receptor blockade. S. PARK*; D. KIM; J. KIM; J. RYU. 

Col. of Pharmacy, Kyung Hee Univ. 

11:00 NNN2 407.4 Post-translational modification 

(PTM) of synaptic proteins regulates long-term memory: 

Bidirectional regulation by protein phosphorylation. B. 

LIN*; N. TABATADZE; A. SCHOOK; A. ROUTTENBERG. 


8:00 NNN3 407.5 Blocking brain eif2 alpha kinase, pkr, 

enhances cortical-dependent memory. E. STERN*; O. DAVID; 

C. ADAIKKAN; N. SONENBERG; K. ROSENBLUM. Univ. of 

Haifa, McGill Univ. 

9:00 NNN4 407.6 DNA methylation and histone acetylation 

regulate reconsolidation of auditory Pavlovian fear memories 

in the lateral amygdala. S. A. MADDOX*; G. E. SCHAFE. Yale 

Univ. 

10:00 NNN5 407.7 Animal model of post-traumatic stress 

disorder (PTSD): Effects of propranolol on exploration in an 

elevated plus maze in rats. G. HANSON GOTTHARD*; J. 

MARINI; S. MANGEL; J. BLOCK; D. TATE; C. HACKMYER. 

Muhlenberg Col. 

11:00 NNN6 407.8 CBP regulates specific hippocampal 

histone modifications and gene expression associated with 

memory formation. R. M. BARRETT*; M. MALVAEZ; A. 

ARRIZON; R. W. GREENE; M. A. WOOD. Univ. California, 

Irvi, Univ. of Texas Southwestern Med. Ctr. and Dallas 

Veterans Admin. Med. Ctr. 

8:00 NNN7 407.9 Differential activation of ERK1/2 and 

Arc/Arg3.1 in the amygdala during novel taste learning 

and conditioned taste aversion. J. CHAVEZ*; J. MORIN; F. 

BERMÚDEZ-RATTONI. Univ. Nacional Autonoma De Mexico. 

9:00 NNN8 407.10 Molecular mechanisms involved in the 

effect of IL-1β on memory consolidation. P. V. GONZALEZ; L. 

CARNIGLIA; I. N. MACHADO; A. VILCAES; M. I. LASAGA; 

T. N. SCIMONELLI*. Fac.Cs.Quimicas IFEC CONICET 

UNC, Ctr. de Investigaciones en Reproduccion. Facultad 

de Medicina UBA, Fac. Cs. Quimicas. CIQUIBIC CONICET 

UNC. 



10:00 NNN9 407.11 • The role of hippocampal astrocytic 

glycogen in working memory in rats. L. A. NEWMAN*; P. E. 

GOLD. Univ. of Illinois Urbana-Champaign. 

11:00 NNN10 407.12 Alpha2-autoreceptors modulate 

norepinephrine release in the basolateral amygdala : A 

mechanism involved in inhibitory avoidance consolidation 

in the rat? B. FERRY*; M. CHAUSSABEL; C. LAZARUS; 

S. PARROT; J. CASSEL. UMR 5020, CNRS / UCB Lyon 1, 

CNRS / ULP, INSERM U512. 

8:00 NNN11 407.13 Arc protein expression in the anterior 

cingulate cortex is modulated by the basolateral complex of 

the amygdala. C. M. HOLLOWAY*; I. A. VILLALOBOS; A. E. 

MONTANA; C. K. MCINTYRE. Univ. Texas, Dallas. 

9:00 NNN12 407.14 Retrieval-induced modulation of contextual 

fear by AMPA receptor plasticity. P. RAO*; D. C. ROTARU; 

R. VAN DER LOO; H. D. MANSVELDER; O. STIEDL; A. B. 

SMIT; S. SPIJKER. Ctr. For Neurogenomics and Cognitive 

Research,NCA, VU Univ. 

10:00 NNN13 407.15 A critical role for insulin-like growth factor 

II in memory consolidation and enhancement. D. Y. CHEN*; 

S. A. STERN; G. POLLONINI; D. BAMBAH-MUKKU; C. M. 

ALBERINI. Mount Sinai Sch. Med. 

11:00 NNN14 407.16 • Physical and cognitive activity induce 

changes in brain and liver glycogen levels in young adult 

male Sprague-Dawley rats. P. E. GOLD*; D. KOROL; C. 

SCAVUZZO. Univ. of Illinois. 

8:00 NNN15 407.17 Effects of intra-hippocampal administration 

of mRNA and protein synthesis inhibitors on performance 

in long-term spatial memory tasks in rats. T. OZAWA*; K. 

YAMADA; Y. ICHITANI. Univ. of Tsukuba. 

9:00 NNN16 407.18 The astrocyte-neuron lactate shuttle is 

essential for hippocampal long-term memory formation. A. 

SUZUKI*; S. A. STERN; O. BOZDAGI; G. W. HUNTLEY; 

P. J. MAGISTRETTI; C. M. ALBERINI. Mount Sinai Sch. of 

Med., Ecole Polytechnique Fédérale de Lausanne, Lausanne 

(EPFL). 

10:00 NNN17 407.19 Posttraining blockade of basolateral 

amygdala norepinephrine attenuates corticosterone-induced 

Arc protein expression in prefrontal cortical synaptic enriched 

fractions. J. R. MCREYNOLDS*; C. M. HOLLOWAY; T. U. 

PARMAR; C. K. MCINTYRE. Univ. of Texas at Dallas. 

11:00 NNN18 407.20 IGF-II and insulin act as memory 

enhancers. S. A. STERN*; D. Y. CHEN; C. M. ALBERINI. Mt. 

Sinai Sch. of Med. 

8:00 NNN19 407.21 Memory reconsolidation mediates memory 

strengthening in a temporally limited fashion. C. INDA*; E. 

MURAVIEVA; G. POLLONINI; C. M. ALBERINI. Mount Sinai 

Sch. of Med. 

9:00 NNN20 407.22 Mechanisms of epinephrine- and glucosemediated 

memory enhancement in young and old Fischer-344 

rats. K. A. MORRIS*; P. E. GOLD. Univ. of Illinois at Urbana- 

Champaign. 

10:00 NNN21 407.23 Molecular convergence between the 

glucocorticoid receptor and bdnf dependent pathways during 

long term memory consolidation. D. BAMBAH-MUKKU*; D. Y. 

CHEN; G. POLLONINI; C. M. ALBERINI. Mount Sinai Sch. of 

Med. 


Mon. AM

11:00 NNN22 407.24 Amygdalar mTOR inhibition impairs 

fear and recognition memory in rats. G. REOLON*; P. 

JOBIM; N. MAURMANN; T. PEDROSO; A. WERENICZ; 

N. MARCONDES; L. PAIM; R. ROESLER. Lab. of Mol. 

Neuropharmacology, Dept. of Pharmacology, Inst., Lab. of 

Mol. Neuropharmacology, Dept. of Pharmacology, Inst. for 

Basic Hlth. Sciences, Federal Univ. of Rio Grande do Sul, 

Porto Alegre, RS, Brazil, Natl. Inst. for Translational Med. 

(INCT-TM), Porto Alegre, RS, Brazil. 

8:00 NNN23 407.25 Posttraining infusions of lidocaine into 

the basolateral complex of the amygdala impair novel 

object recognition memory and decrease Arc protein 

expression in the dorsal hippocampus. K. M. PREWIT*; J. R. 

MCREYNOLDS; N. VUU; C. K. MCINTYRE. Univ. of Texas at 

Dallas. 

9:00 NNN24 407.26 Temporal dynamics of the requirement 

for bdnf and protein synthesis during long term memory 

consolidation. D. BAMBAH-MUKKU; D. Y. CHEN; G. 

POLLONINI; C. M. ALBERINI*. Mount Sinai Sch. Med. 

POSTER 

408. Invertebrate Learning and Memory: Arthropod and 

Nematode 



8:00 NNN25 408.1 Trace conditioning in Drosophila. Y. 

SHUAI*; Y. HU; Y. ZHONG. Cold Spring Harbor Lab., 

Tsinghua Univ. 

9:00 NNN26 408.2 The gene EIF-5C exerts pleiotropic effect 

in aversive and appetitive learning and memory in Drosophila. 

B. LU*; W. GUO; X. ZHAO; Y. SHUAI; Y. ZHONG. Tsinghua 

Univ., Cold Spring Harbor. 

10:00 NNN27 408.3 The role of dopamine in operant learning 

during conditioned courtship suppression using drosophila 

melanogaster. J. L. JOHNSON*; J. LIM; K. HAN. Univ. of 

Texas At El Paso. 

11:00 NNN28 408.4 Mutant serotonin receptor 5-HT7R alters 

Drosophila olfactory larval learning and central synaptic 

modulation. D. LEE*; A. GANGULY; M. DOLAN. Ohio Univ. 

8:00 NNN29 408.5 Time-memory expression in honey bees: 

Dance floor correlates. A. E. WAGNER*; B. N. VAN NEST; C. 

HOBBS; D. MOORE. East Tennessee State Univ. 

9:00 NNN30 408.6 Time-memory expression in honey bees: 

Influence of foraging experience. B. N. VAN NEST*; A. E. 

WAGNER; C. HOBBS; D. MOORE. East Tennessee State 

Univ. 

10:00 NNN31 408.7 Spatial behavior and learning in the 

crayfish Orconectes rusticus. A. J. TIERNEY*; J. LEE; A. N. 

BYRNE. Colgate Univ. 

11:00 NNN32 408.8 High throughput behavioral 

characterization of habituation in wild-type C. elegans and a 

mutant library of nervous-system-biased strains. A. C. GILES; 

N. SWIERCZEK; R. A. KERR; C. H. RANKIN*. Univ. British 

Columbia, Janelia Farm Resaerch Campus, HHMI. 

8:00 NNN33 408.9 Associative learning and long-term 

memory in C. elegans. S. NISHIJIMA; H. AMANO; I. 

MARUYAMA*. Okinawa Inst. of Sci. & Technol. 

9:00 NNN34 408.10 Pre-exposure effects on drug preference 

in Caenorhabditis elegans. H. N. MUSSELMAN*; K. 

RALSTON; C. A. GUEST-WILLIAMS; B. S. NEAL-BELIVEAU; 

E. A. ENGLEMAN. Indiana Sch. of Med., IUPUI. 

10:00 NNN35 408.11 Conditioned place preference in 

Caenorhabditis elegans. C. A. GUEST-WILLIAMS; H. N. 

MUSSELMAN; E. A. ENGLEMAN; B. S. NEAL-BELIVEAU*. 

IUPUI, Indiana Univ. Sch. of Med. 

11:00 NNN36 408.12 Long-lasting olfactory memory in C. 

elegans: A role for protein kinase C (PKC) in forgetting? 

A. PANJWANI; M. CZECH; S. KOH; J. GRUBER; B. 

HALLIWELL; T. B. PENNEY*; A. ROUTTENBERG. 

Northwestern Univ., Natl. Univ. of Singapore. 

POSTER 

409. Invertebrate Learning and Memory: Mollusc 



8:00 NNN37 409.1 • Direct single cell methylome profiling 

in memory circuits: Rapid and massive DNA demethylation 

induced by neurotransmitters. L. L. MOROZ; M. CITARELLA; 

M. LYONS; E. LEVANDOWSKY; C. LEE; K. MCKERNAN; 

A. B. KOHN*. Univ. of Florida, Whitney Lab., Dept. of 

Neuroscience, Univ. of Florida, Life Technologies, Universtiy 

of Florida Whitney Lab. 

9:00 NNN38 409.2 • Neuromediators effect on neural genome 

activity is Ca2+-dependent in in vivo model of learning: 

Imaging using DNA-selective probe SYTO16AM. A. V. 

SHEVELKIN*; A. K. TIMOSHENKO. P.K.Anokhin Inst. Norm 

Physiol, Res. Inst. for Problems of Ecology and Mineral 

Wealth Use of Tatarstan Acad. of Sci. 

10:00 NNN39 409.3 Spontaneous transmitter release from 

the presynaptic neuron initiates a cascade of pre- and 

postsynaptic mechanisms for intermediate- and long-term 

facilitation and synaptic growth in Aplysia. I. JIN*; H. UDO; S. 

PUTHANVEETIL; J. B. RAYMAN; H. D. VISHWASRAO; E. R. 

KANDEL; R. D. HAWKINS. Columbia Univ., Kyushu Univ. 

11:00 NNN40 409.4 Circadian modulation of intermediate-term 

memory in aplysia via protein phosphatases. M. MICHEL*; C. 

L. GREEN; J. GARDNER; L. C. LYONS. Florida State Univ. 

8:00 NNN41 409.5 Rapid and persistent suppression of 

feeding behavior induced by one-trial sensitization training in 

aplysia. R. MOZZACHIODI*; A. ACHEAMPONG; K. KELLY; 

J. HAJOVSKY; M. SHIELDS-JOHNSON; M. WAINWRIGHT. 

Texas A&M University-Corpus Christi, Houston Community 

Col. Syst., Endicott Col. 

9:00 NNN42 409.6 Inhibiting PKM reverses a molecular 

mechanism of long-term sensitization in Aplysia. S. CHEN*; 

K. C. PEARCE; D. CAI; D. L. GLANZMAN. Univ. of California 

Los Angeles. 

10:00 NNN43 409.7 • � Behavioral, physiological, and genetic 

analysis of habituation of the Aplysia tail-elicited siphon 

withdrawal reflex. K. BONNICK; B. MCBRIDE; L. SALAZAR; 

R. KROES; J. MOSKAL; R. CALIN-JAGEMAN*; I. CALIN- 

JAGEMAN. Dominican Univ., Falk Ctr. for Mol. Therapeut. 

11:00 NNN44 409.8 Long-term but not short-term savings 

memory in the tail-elicited siphon withdrawal reflex of Aplysia 

requires protein synthesis. G. T. PHILIPS*; S. A. MENGES; A. 

A. PILIKYAN; T. J. CAREW. Univ. of California, Irvine. 

8:00 NNN45 409.9 Tyrosine kinase activity is required during 

activity-dependent analogue training for the persistent transcompartmental 

activation of MAPK activation in aplysia. S. 

STOUGH*; A. ZOMORRODI; T. J. CAREW. Univ. California, 

Irvine. 



9:00 NNN46 409.10 Delayed up-regulation of Aplysia p75NTRlike 

molecule (ApP75L) mRNA following repeated tail nerve 

shocks. L. PU*; J. L. SHOBE; H. D. BOYLE; T. J. CAREW. UC 

Irvine. 

10:00 NNN47 409.11 Possible contributions of Ca-inhibited 

adenylyl cyclase and calmodulin-activated phosphodiesterase 

in associative, cAMP-dependent plasticity in Aplysia sensory 

neurons. S. LU; A. H. LIN; T. W. ABRAMS*; P. SHRESTHA. 

Univ. of Maryland Med. Sch. 

11:00 NNN48 409.12 Expression of synapsin is necessary for 

long-term synaptic facilitation in Aplysia. A. K. NETEK*; L. J. 

CLEARY; J. H. BYRNE. Univ. Texas Med. Sch, Houston. 

8:00 NNN49 409.13 PKC-dependent vesicle mobilization can 

account for the 5-HT-induced facilitation of both depressed 

and non-depressed SN-MN synapse in Aplysia. L. ZHOU*; D. 

A. BAXTER; J. H. BYRNE. Univ. of Texas Med. at Houston, 

Univ. of Texas Med. Sch. at Houston. 

9:00 NNN50 409.14 Characterization of Aplysia adenylyl 

cyclase B: A cyclase implicated in operant conditioning. H. 

CHEN*; D. BAXTER; J. BYRNE. The Univ. of Texas Med. 

Sch. At Houston. 

10:00 OOO1 409.15 Time window for requirement of CREB1 

feedback loop in the consolidation of long-term facilitation of 

the sensorimotor synapse of Aplysia. R. LIU*; L. J. CLEARY; 

J. H. BYRNE. Univ. Texas Med. Sch. Houston. 

11:00 OOO2 409.16 De novo protein synthesis of syntaxin-1 

and dynamin-1 in long-term memory formation requires 

CREB1 gene transcription in Lymnaea stagnalis. K. LI*; C. 

GUO; A. SENZEL. Univ. of Toronto. 

8:00 OOO3 409.17 Nitric oxide is necessary for both 

erasure and consolidation of memory during learning. P. M. 

BALABAN*; M. V. ROSCHIN; T. KORSHUNOVA. Inst. Higher 

Nervous Activity & Neurophysiol. 

9:00 OOO4 409.18 GABA-B receptor participation in 

the release of 12(S)-HPETE in Hermissenda Type B 

photoreceptors via PLA2. T. L. WALKER*; J. J. JOHNSON; J. 

FARLEY. Indiana Univ. 

10:00 OOO5 409.19 Large-scale optical recording reveals rapid 

network expansion during sensitization of the Tritonia escape 

swim motor program. E. S. HILL*; J. WANG; S. VASIREDDI; 

W. N. FROST. The Chicago Med. School, Rosalind Franklin 

Univ. 

POSTER 

410. Motivation and Emotion: Emotional Information 

Processing 



8:00 OOO6 410.1 Discrimination of emotion: Application to 

English language learning. J. LEE; I. M. WHITE*. Korea Natl. 

Univ. of Educ., Morehead State Univ. 

9:00 OOO7 410.2 The influence of cognitive regulation on 

the anticipation of monetary losses. L. N. MARTIN*; M. R. 

DELGADO. Rutgers, The State Univ. of New Jersey. 

10:00 OOO8 410.3 Moderate intensity exercise enhances 

positive emotional bias and reduces negative emotional bias. 

Q. TIAN*; J. C. SMITH. Univ. of Wisconsin-Milwaukee. 

11:00 OOO9 410.4 � Memory and emotion. Separated or 

related processes? E. ROSAS*; Y. G. SANCHEZ. Natl. 

Autonomous Univ. of Mexico. 



8:00 OOO10 410.5 Emotion regulation in depersonalization 

disorder: An erp study. K. MONDE*; D. SIMEON; T. A. 

DENNIS. Hunter Col., Grad. Ctr. of the City Univ. of New York, 

Beth Israel Med. Ctr. 

9:00 OOO11 410.6 Biological brain aging accounts for a 

reduction in the negativity bias in older adults. K. DOLGE*; 

U. M. STAUDINGER; C. VOELCKER-REHAGE; B. GODDE. 

Jacobs Univ. 

10:00 OOO12 410.7 Neural basis of positive emotion revealed 

through inter-subject synchronization. Z. A. ENGLANDER*; J. 

HAIDT; J. P. MORRIS. Univ. of Virginia. 

11:00 OOO13 410.8 • Smoking abstinence results in 

dysregulated emotional information processing. B. 

FROELIGER*; L. MODLIN; R. KOZINK; L. WANG; F. J. 

MCCLERNON. Duke Univ. Med. Ctr. 

8:00 OOO14 410.9 Move happy and be happy: Effects of 

dynamic body expressions of emotions on brain activation 

and affective state. T. SHAFIR*; S. F. TAYLOR; S. A. 

LANGENECKER; J. K. ZUBIETA. Univ. Michigan. 

9:00 OOO15 410.10 Correlation between sound-induced 

aversiveness and autonomic response. Y. OOISHI*; M. 

KASHINO. NTT, Tokyo Inst. of Technol. 

POSTER 

411. Neuroethology: Vocal Communication-Motor Mechanisms 

and Production 



8:00 OOO16 411.1 Respiratory patterning and forebrain 

involvement in early song development. L. VEIT*; D. 

ARONOV; M. S. FEE. MIT. 

9:00 OOO17 411.2 Two distinct forms of forebrain dynamics 

underlie the production of an early motor behavior. D. 

ARONOV*; L. VEIT; J. H. GOLDBERG; M. S. FEE. MIT. 

10:00 OOO18 411.3 Does HVC control the timing of respiratory 

events during singing? A. S. ANDALMAN*; J. N. FOERSTER; 

M. S. FEE. MIT. 

11:00 OOO19 411.4 What syntactic operations do zebra 

finches make during imitation? Evidence from experimental 

manipulation of song development. D. LIPKIND; O. FEHER; 

P. RAVBAR; G. MARCUS; O. TCHERNICHOVSKI*. CCNY, 

RIKEN Brain Sci. Inst., New York Univ. 

8:00 OOO20 411.5 Vocal exploration changes dynamically at 

the sub-syllabic level during song learning. P. RAVBAR*; L. C. 

PARRA; O. TCHERNICHOVSKI. CCNY, CUNY. 

9:00 OOO21 411.6 • Syringeal lateralization of song production 

in the Bengalese finch. K. R. SECORA; J. R. PETERSON; B. 

CHUNG; B. G. COOPER*. Texas Christian Univ. 

10:00 OOO22 411.7 Evidence that a vocal impediment is 

caused by impaired interhemispheric coordination of brain 

activity. E. T. VU*; M. BEHBAHANINIA; I. HSU. Barrow Neurol 

Inst., Arizona State Univ. 

11:00 OOO23 411.8 Sound production in the isolated mouse 

larynx. S. W. BERQUIST; J. P. HO; W. METZNER*. UCLA. 

8:00 OOO24 411.9 Characterizing birdsong through spectral 

density functions. J. MARKOWITZ*; T. GARDNER. Boston 

Univ. 


Mon. AM

9:00 OOO25 411.10 Altered auditory feedback by 

selective syllable muting in a songbird. A. AMADOR*; D. 

MARGOLIASH. Univ. of Chicago. 

10:00 OOO26 411.11 Repeated evolution of activity-dependent 

motor-driven dusp1 expression in song nuclei of vocal 

learning birds. H. HORITA*; M. KOBAYASHI; K. OKA; E. D. 

JARVIS; K. WADA. Howard Hughes Med. Institute, Duke 

Univ. Med. Ctr., Sch. of Fundamental Sci. and Technology, 

Keio Univ., Sch. of Life Science, Hokkaido Univ., Fac. of 

Science, Hokkaido Univ. 

11:00 OOO27 411.12 Vocalizations induce persistent ultrafast 

gamma oscillations in a premotor nucleus. B. C. 

LEWANDOWSKI*; M. F. SCHMIDT. Univ. of Pennsylvania. 

8:00 OOO28 411.13 Intrinsic properties and morphology 

of vocal motoneurons are well adapted for synchronous 

oscillatory firing in the high gamma range. B. P. CHAGNAUD*; 

M. C. ZEE; R. BAKER; A. H. BASS. Cornell Univ., 

Northeastern Univ., NYU. 

POSTER 

412. Optogenetics II 

Theme G: Novel Methods and Technology Development 


8:00 OOO29 412.1 Cholinergic interneurons of the nucleus 

accumbens control local circuit activity and reward behavior. 

I. B. WITTEN*; S. LIN; M. BRODSKY; P. ANIKEEVA; I. 

DIESTER; C. RAMAKRISHNAN; K. DEISSEROTH. Stanford 

Univ. 

9:00 OOO30 412.2 Optogenetic stimulation of cholinergic 

fibers elicits distinct physiological effects onto hippocampal 

interneuron subtypes. V. C. SATPUTE; A. D. JOHNSTON; 

B. A. BENNETT; B. B. HOLLOWAY; J. T. VAN LEUVAN; 

E. STONE; K. DEISSEROTH; J. J. LAWRENCE*. Univ. of 

Montana, Stanford Univ. 

10:00 OOO31 412.3 • Optogenetic inhibition of dorsal CA1 

enables reversible interruption of memory acquisition 

and recall. I. GOSHEN*; M. BRODSKY; V. GRADINARU; 

C. RAMAKRISHNAN; K. DEISSEROTH. Dept. of 

Bioengineering, Stanford Univ., Dept. of Psychiatry, Stanford 

Univ. 

11:00 OOO32 412.4 Noninvasive and fiberoptic-free 

optogenetics in freely moving mammals: Novel opsin-based 

approaches applied to modulation of prefrontal circuitry. 

L. E. FENNO*; O. YIZHAR; M. PRIGGE; V. SOHAL; I. 

GOSHEN; C. RAMAKRISHNAN; S. PAK; P. HEGEMANN; K. 

DEISSEROTH. Stanford Univ., Humboldt-University. 

8:00 OOO33 412.5 Increasing the fidelity of optogenetic 

control with an expanded panel of channelrhodopsin kinetic 

variants. L. A. GUNAYDIN*; O. YIZHAR; A. BERNDT; V. S. 

SOHAL; J. MATTIS; L. FENNO; C. RAMAKRISHNAN; P. 

HEGEMANN; K. DEISSEROTH. Stanford Univ., Humboldt 

Univ. 

9:00 OOO34 412.6 Testing AAV viral vectors for optogenetic 

gene delivery in macaque cortex. M. C. DADARLAT; S. 

REDMOND; P. N. SABES*. UCSF-UC Berkeley, Dept. of 

Physiol. and the Keck Ctr. for Integrative Neuroscience, 

UCSF. 

10:00 OOO35 412.7 Endogenous anxiolytic mechanisms 

identified by projection-specific optogenetic control of 

amygdala microcircuitry. K. M. TYE*; L. E. FENNO; S. KIM; R. 

PRAKASH; H. ZARABI; K. THOMPSON; L. M. GROSENICK; 

V. GRADINARU; C. RAMAKRISHNAN; K. DEISSEROTH. 


11:00 OOO36 412.8 Cell-type specific optogenetic mice for 

dissecting neural circuitry function. S. ZHAO; L. QIU; J. TING; 

J. TAN; B. GLOSS; K. DEISSEROTH; M. LUO; G. FENG*. 

Duke Univ. Med. Ctr., Natl. Inst. of Biol. Sci., Stanford Univ. 

8:00 OOO37 412.9 An optogenetic toolbox designed 

for primates. I. DIESTER*; W. GOO; M. KAUFMAN; R. 

PASHAIE; M. MOGRI; O. YIZHAR; C. RAMAKRISHNAN; 

K. DEISSEROTH; K. V. SHENOY. Stanford Univ., Univ. of 

Wisconsin-Milwaukee. 

9:00 OOO38 412.10 Optogenetic fMRI: Local and global fMRI 

signals driven by neurons with specified type and wiring. J. 

LEE*; R. DURAND; V. GRADINARU; F. ZHANG; I. GOSHEN; 

D. KIM; L. FENNO; C. RAMAKRISHNAN; K. DEISSEROTH. 

UCLA, Stanford Univ., Korea Advanced Institue of Sci. and 

Technol. 

10:00 OOO39 412.11 Optetrodes: Combined optogenetic 

control and tetrode-based electrophysiological recording in 

freely moving mice. P. ANIKEEVA; I. WITTEN; M. WARDEN; 

I. GOSHEN; L. FRANK; K. DEISSEROTH*. Stanford Univ., 

Univ. of California, San Francisco. 

11:00 OOO40 412.12 Expanding the toolbox for targeting 

genetically- and topologically-defined components of neural 

circuits. J. H. MATTIS*; C. RAMAKRISHNAN; I. DIESTER; 

R. SQUIRE; F. ZHANG; K. DEISSEROTH. Stanford Univ., 

Harvard Univ. 

8:00 OOO41 412.13 Optogenetic control of cerebellar 

interneurons. X. ZHANG*; B. ASRICAN; C. CUNHA; B. 

GLOSS; Y. YOSHIMURA; Y. KOMATSU; G. FENG; G. J. 

AUGUSTINE. Duke Univ. Med. Ctr., NYU, Marine Biol. Lab., 

Nagoya Univ., Duke-NUS Grad. Med. Sch. 

9:00 OOO42 412.14 Optogenetic mapping of local inhibitory 

circuitry in cerebellum reveals spatial coordination of 

interneurons via electrical synapses. J. KIM*; S. TSUDA; 

S. LEE; M. KEE; C. CUNHA; G. FENG; G. J. AUGUSTINE. 

Duke-Nus Grad. Med. Sch. Singapore, Marine Biol. Lab., New 

York Univ., Duke Univ. 

POSTER 

413. Novel Methods: Electrophysiology I 



8:00 OOO43 413.1 Transcranial direct current stimulation 

(TDCS) produces localized and specific increases in 

glutamate/glutamine and NAA. V. P. CLARK*; B. A. 

COFFMAN; M. C. TRUMBO; C. GASPAROVIC. Univ. of New 

Mexico, Mind Res. Network, Univ. of New Mexico and Mind 

Res. Network. 

9:00 OOO44 413.2 Dual mechanism of auditory suppression 

during speech production: Evidence from direct cortical 

recordings. A. SHESTYUK*; A. FLINKER; E. CHANG; N. M. 

BARBARO; J. PARVIZI; N. E. CRONE; R. T. KNIGHT. Univ. of 

California, Stanford Univ., Johns Hopkins Univ. Sch. of Med. 

10:00 OOO45 413.3 EEGLAB: A software environment 

for advanced EEG signal processing. A. DELORME*; S. 

MAKEIG. SCCN, INC, UCSD, Paul Sabatier Univ. 



11:00 OOO46 413.4 Assessing the transience assumption for 

high-frequency repetitive transcranial magnetic stimulation 

during a cognitive task. J. S. JOHNSON*; M. HAMIDI; E. 

FEREDOES; B. R. POSTLE. Univ. of Wisconsin-Madison, 

Univ. Col. London. 

8:00 OOO47 413.5 252-site subdural LFP recordings 

in monkeys unveil dynamical inteareal communication 

modulated by selective attention. C. BOSMAN*; T. 

WOMELSDORF; R. OOSTENVELD; B. RUBEHN; P. DE 

WEERD; T. STIEGLITZ; P. FRIES. Radboud Univ., Univ. of 

Western Ontario, Ernst Strüngmann Inst., Univ. of Freiburg, 

Maastricht Univ. 

9:00 OOO48 413.6 A neural signature of mental time travel. 

J. R. MANNING*; S. M. POLYN; M. J. KAHANA. Univ. 

Pennsylvania, Vanderbilt Univ. 

10:00 OOO49 413.7 The neural basis of cortical-stimulationinduced 

memory retrieval in humans. J. JACOBS*; B. LEGA; 

C. T. ANDERSON. Univ. Pennsylvania, Hosp. of the Univ. of 

Pennsylvania. 

11:00 OOO50 413.8 • Individual differences in neural activity 

predict the transcranial magnetic stimulation-evoked 

response. B. KUNDU*; J. S. JOHNSON; B. R. POSTLE. Univ. 

of Wisconsin, Madison. 

8:00 OOO51 413.9 Effect of non-selective dopamine D1 and 

D2 receptor agonist, apomorphine, on firing rate of neurons 

in the ventral pallidum. A. HAGHPARAST*; D. FARZIN; M. 

ORDIKHANI-SEYEDLAR. Shahid Beheshti Univ. of Med. Sci., 

Mazandaran Univ. of Med. Sci. 

9:00 OOO52 413.10 Combining diffusion tensor imaging (DTI) 

and multiple-electrode recordings to study neural networks: 

An example focusing on thalamocortical interactions. Y. B. 

SAALMANN*; M. A. PINSK; X. LI; S. KASTNER. Princeton 

Univ. 

10:00 OOO53 413.11 Interareal directed interactions and their 

modulation by selective attention assessed with high density 

electrocorticography in monkey. A. BASTOS*; C. A. BOSMAN; 

J. SCHOFFELEN; R. OOSTENVELD; P. FRIES. UC Davis, 

Radboud Univ. Nijmegen, 3. Ernst Strüngmann Inst. in 

Cooperation with Max Planck Society. 

11:00 OOO54 413.12 Measures of cortical inhibition by pairedpulse 

transcranial magnetic stimulation in anesthetized rats. A. 

VAHABZADEH-HAGH*; P. MULLER; A. PASCUAL-LEONE; 

F. JENSEN; A. ROTENBERG. Harvard Med. Sch., Children’s 

Hosp., Beth Israel Deaconess Med. Ctr., Univ. Autónoma. 

8:00 OOO55 413.13 Support for a synaptic chain model of 

sequence generation from intracellular recordings in the 

singing bird. M. A. LONG*; M. S. FEE. NYU Sch. of Med., MIT. 

9:00 OOO56 413.14 • Segmental innervation of the Göttingen 

minipig hind limb. K. MEIER*; K. S. ETTRUP; E. QERAMA; A. 

K. O. ALSTRUP; J. C. H. SØRENSEN. Aarhus Univ. Hosp. 

10:00 OOO57 413.15 • 12-segment cuff is superior to ring cuff 

for sensing and stimulation of cardiac fibers in the vagal trunk. 

S. C. ORDELMAN*; L. KORNET; R. CORNELUSSEN; H. P. J. 

BUSCHMAN; P. H. VELTINK. Univ. of Twente, Medtronic. 

11:00 OOO58 413.16 • QPatch HTX: Biophysical and 

pharmacological characterization of ligand-gated ion 

channels in multi-hole mode. M. JENSEN; R. SCHRØDER; 

H. L. OLSEN; R. B. JACOBSEN; J. WEBBER; S. FRIIS; 

D. NIELSEN; M. T. CHRISTENSEN; M. SUNESEN; C. 

MATHES*. Sophion Biosci. A/S, Sophion Bioscience, Inc. 



8:00 OOO59 413.17 Intra-cranial electrophysiology (ICE) of 

language: Chronicling spatiotemporal stages and connectivity 

from visual input to motor output. N. T. SAHIN*; S. PINKER; 

T. THESEN; S. S. CASH; O. DEVINSKY; R. KUZNIECKY; 

W. DOYLE; E. HALGREN. Univ. of California At San Diego, 

Harvard Univ., New York Univ., Massachusetts Gen. Hosp., 

Univ. of California at San Diego. 

9:00 OOO60 413.18 Interaction between prefrontal cortex and 

medial temporal lobe in human memory: An ECOG study. M. 

DING*; K. ANDERSON; R. RAJAGOVINDAN; G. GHACIBEH; 

K. MEADOR. Univ. Florida, Northeast Regional Epilepsy 

Group, Emory Univ. 

10:00 OOO61 413.19 Synchronization in spontaneous activity 

of bilateral somatosensory cortices of rat measured by 

laminar electrodes. K. BAEK*; J. JEONG; W. SHIM; H. 

RADHAKRISHNAN; D. BOAS; M. FRANCESCHINI; B. 

ROSEN; Y. R. KIM. MGH/HST Martinos Ctr. For Biomed. 

Imaging, KAIST. 

11:00 OOO62 413.20 In-cell recording and stimulation by an 

array of extracellular microelectrodes. A. HAI*; J. SHAPPIR; 

M. SPIRA. Dept. of Neurobiology, Inst. of Life Sciences, 

Hebrew Univ. of Jerusalem, Sch. of Engineering, Hebrew 

Univ. of Jerusalem. 

8:00 OOO63 413.21 A stretchable electrode array 

for non-invasive, skin-mounted measurement of 

electroencephalography (eeg). R. MA*; D. KIM; M. 

MCCORMICK; T. COLEMAN; J. ROGERS. Univ. of Illinois At 

Urbana-Champaign, Univ. of Illinois at Urbana-Champaign. 

9:00 OOO64 413.22 Epicortical recordings with flexible, allpolymer 

electrode arrays (polyMEAs). A. BLAU*; P. MEDINI; 

G. IURILLI; F. DIFATO; F. BENFENATI. The Italian Inst. of 

Technol. (IIT). 

10:00 OOO65 413.23 Using intracranial oscillatory patterns to 

bridge cognitive and neural theories of memory search. S. M. 

POLYN*; N. W. MORTON; M. J. KAHANA. Vanderbilt Univ., 


11:00 OOO66 413.24 Fabrication of 3d multisensing electrodes 

for in vivo neuronal unit recordings. J. C. WOLFE*; M. 

GHEEWALA; W. SHIH; J. A. DANI. Univ. of Houston, Baylor 

Col. of Med. 

8:00 OOO67 413.25 Holistic processing of faces in the 

human brain revealed through intracranial EEG recordings. 

I. DAVIDESCO; S. BICKEL; E. ZION-GOLUMBIC; M. 

HAREL; G. GOELMAN; C. E. SCHROEDER; A. D. MEHTA; 

R. MALACH*. Hebrew Univ., Long Island Jewish Med. Ctr., 

Columbia Univ. Col. of Physicians and Surgeons, Nathan 

Kline Inst., Weizmann Inst., Hadassah Hebrew Univ. Med. Ctr. 

9:00 OOO68 413.26 Characterizing distinct modes of neuronal 

processing for rhythmic vs. non-rhythmic auditory stimuli. E. 

M. ZION GOLUMBIC*; S. BICKEL; P. LAKATOS; A. MEHTA; 

J. ISLER; C. SCHEVON; R. EMERSON; C. E. SCHROEDER. 

Columbia Univ., Nathan Kline Inst. for Psychiatric Res., Long 

Island Jewish Hosp. 

10:00 OOO69 413.27 Electrical stimulation of in vitro cultured 

neurons and organotypic brain slices with a novel type of 

microelectrode arrays. D. BRAEKEN*; S. CHONG; R. HUYS; 

G. CALLEWAERT; W. EBERLE. IMEC, K. U. Leuven. 

11:00 OOO70 413.28 An electrophysiological information flow 

toolbox for EEGLAB. T. MULLEN*; S. MAKEIG. UCSD, 

SCCN, Inst. for Neural Computation. 


Mon. AM

8:00 OOO71 413.29 Synchonization within an attentional 

network of the human neocortex. J. R. ISLER; J. BESLE; C. 

A. SCHEVON; A. D. MEHTA; P. LAKATOS; R. R. GOODMAN; 

G. M. MCKHANN; R. G. EMERSON; C. E. SCHROEDER*. 

Columbia Univ., Long Island Jewish Med. Ctr., Nathan Kline 

Inst. Psychiat Res. 

9:00 OOO72 413.30 Topography of history-dependent cortical 

processing mapped using iEEG. C. J. HONEY*; T. THESEN; 

T. H. DONNER; L. J. SILBERT; C. CARLSON; W. K. DOYLE; 

O. DEVINSKY; N. RUBIN; D. J. HEEGER; U. HASSON. 

Princeton Univ., New York Univ. Sch. of Med., Univ. of 

Amsterdam. 

POSTER 

414. Neural Network Structure and function: Theory 



8:00 OOO73 414.1 Rethinking approximations of channel 

noise in stochastic Hodgkin-Huxley models. J. H. 

GOLDWYN*; M. FAMULARE; N. S. IMENNOV; A. FAIRHALL; 

J. T. RUBINSTEIN; E. SHEA-BROWN. Univ. Washington. 

9:00 OOO74 414.2 The role of H-current on sub-threshold 

activity: A simulation study. F. ARENCIBIA-ALBITE*; C. A. 

JIMÉNEZ-RIVERA. Univ. of Puerto Rico. 

10:00 PPP1 414.3 The role of calcium-dependent K+ channel 

in subthreshold resonance oscillation. T. KITAJIMA*; Z. FENG; 

S. KUBOTA. Yamagata Univ. 

11:00 PPP2 414.4 Optimal control methods and energy 

minimization in neuron models. M. ELLINGER*; M. E. 

KOELLING; D. A. MILLER; J. STAHL; F. L. SEVERANCE. 

Western Michigan Univ. 

8:00 PPP3 414.5 Coincidence detection in neurons with in 

vivo-like synaptic activity. C. ROSSANT; R. BRETTE*. Ecole 

Normale Supérieure. 

9:00 PPP4 414.6 The geometry of phase resetting and 

its relationship with the underlying ionic mechanisms. S. 

OPRISAN*; A. J. SMITH; R. A. RAIDT. Col. of Charleston. 

10:00 PPP5 414.7 Phase reduction of neuronal oscillators 

perturbed by Ito process. T. YAMANOBE*. Hokkaido 

University, Sch. of Med., PRESTO, Japan Sci. and Technol. 

Agency (JST). 

11:00 PPP6 414.8 Learning Bayesian priors in a recurrent 

network with STDP. A. LAZAR*; G. PIPA; J. TRIESCH. Max- 

Planck Inst. For Brain Res., Frankfurt Inst. for Advanced 

Studies. 

8:00 PPP7 414.9 Biologically plausible homeostasis and 

STDP: Stability and learning patterned inputs in spiking 

neural networks. M. RICHERT*; J. MOORKANIKARA 

NAGESWARAN; N. DUTT; J. KRICHMAR. UCI. 

9:00 PPP8 414.10 Emergent local topology (motifs) in a selforganizing 

network of model neurons. D. B. STONE*; C. D. 

TESCHE. Univ. New Mexico. 

10:00 PPP9 414.11 Pair-wise correlation is not sufficient to 

model neuronal avalanches. S. YU*; H. YANG; D. PLENZ. 

Section On Critical Brain Dynamics, Natl. Inst. of Mental Hlth., 

Univ. of Maryland. 

11:00 PPP10 414.12 • From fractal, lego, ascii to neural 

network. A. CHOU*. Mobil Res. and Develop. Corp. 

8:00 PPP11 414.13 • Neural networks with Hierarchical 

temporal memory using Izhikevich type neurons. S. PARK; J. 

LEE; D. LEE; T. KO; D. KIM*. KAIST, NIMS. 

9:00 PPP12 414.14 A simple framework for complex networks. 

D. Q. NYKAMP*; L. ZHAO; T. NETOFF. Univ. Minnesota. 

10:00 PPP13 414.15 Perception as Modeling: A neural network 

that extracts and models predictable elements of its input. D. 

S. SUSSILLO*; L. F. ABBOTT. Columbia Univ. 

11:00 PPP14 414.16 Reducing spiking networks to firing rate 

models with spiking dynamics. E. S. SCHAFFER*; L. F. 

ABBOTT. Columbia Univ. 

8:00 PPP15 414.17 Dynamic gating in multi-modular neural 

networks using random connections. O. BARAK*; M. 

RIGOTTI; S. FUSI. Columbia Univ. 

9:00 PPP16 414.18 Dynamical response and 

spike correlations in threshold neuron models. T. 

TCHUMATCHENKO*; A. MALYSHEV; T. GEISEL; M. 

VOLGUSHEV; F. WOLF. Dynamics and Self-Organization, 

Bernstein Ctr. for Computat. Neurosci., Göttingen Grad. Sch. 

for Neurosciences and Mol. Biosci., Inst. of Higher Nervous 

Activity and Neurophysiol., Univ. of Connecticut, Ruhr- 

University Bochum. 

POSTER 

415. fMRI Methods 



8:00 PPP17 415.1 Pre-surgical language mapping using 

resting-state fMRI. Y. TIE*; W. WU; L. RIGOLO; S. SHRIVER; 

A. GOLBY. Brigham and Women’s Hosp, Harvard Med. Sch., 

West China Hospital, Sichuan Univ. 

9:00 PPP18 415.2 Method for assessing selection bias in 

fMRI resting-state functional connectivity. R. T. KUPLICKI; 

W. COBERLY; J. BODURKA; W. K. SIMMONS; P. S. 

BELLGOWAN*. Univ. of Tulsa, Laureate Inst. For Brain Res. 

10:00 PPP19 415.3 Resting state interhemispheric functional 

connectivity reflects anatomical connectivity in the split brain. 

H. PARK*; J. KIM; B. PARK; J. LEE; H. KIM. Yonsei Univ. Col. 

Med., Brain Korea 21 Project for Med. Science, Yonsei Univ. 

Col. of Med. 

11:00 PPP20 415.4 Memetic optimization of informative brain 

regions for multivoxel pattern recognition. M. B. ABERG*; J. 

WESSBERG. Malin Björnsdotter (aberg), Univ. of Gothenburg. 

8:00 PPP21 415.5 A comparison of methods for the use of 

pattern classification on rapid event-related fMRI data. B. O. 

TURNER*. Univ. of California, Santa Barbara. 

9:00 PPP22 415.6 Tract alignment errors decrease detection 

power in group analyses of diffusion data with TBSS. J. M. 

TSANG*; R. F. DOUGHERTY; B. A. WANDELL. Stanford 

Univ. 

10:00 PPP23 415.7 Region-specific characteristics of defaultmode 

networks from fMRI data analysis. J. LEE*; D. KIM; J. 

KIM; Y. KIM; M. SA. Korea Univ. 

11:00 PPP24 415.8 Automated artefact removal in fMRI 

time series. N. KOVACEVIC*; M. TASSOPOULOS; A. R. 

MCINTOSH. Baycrest Ctr. for Geriatric Care. 

8:00 PPP25 415.9 A FSL-based pipeline for fMRI data 

preprocessing. L. HUANG*; E. L. PARKS; M. N. BALIKI; 

J. A. HASHMI; B. PETRA; A. T. BARIA; A. V. APKARIAN. 




9:00 PPP26 415.10 Effective connectivity analysis of fMRI 

and MEG data collected under identical paradigms. S. M. 

PLIS*; E. DAMARAJU; C. L. WOOTTON; L. M. BULLARD; 

V. P. CLARK; B. A. COFFMAN; E. B. KIMBALL; A. J. VAN 

DER MERWE; K. PAULSON; A. VAKHTIN; D. PUFFER; R. 

BARROW; C. GARCIA; M. P. WEISEND. The Mind Res. 

Network, Univ. of New Mexico. 

10:00 PPP27 415.11 DTI-based analysis of thalamic anatomy 

in stroke patients. A. DJAMANAKOVA; A. V. FARIA; X. LI; H. 

JIANG; K. OISHI; A. HILLIS; M. I. MILLER; S. MORI*. Johns 

Hopkins Univ. 

11:00 PPP28 415.12 Assessing functional connectivity 

through phase coherence in narrowband fMRI BOLD 

signal: Attention networks in event-related and naturalistic 

settings. E. GLEREAN*; J. SALMI; J. LAHNAKOSKI; I. P. 

JÄÄSKELÄINEN; J. LAMPINEN; M. SAMS; K. ALHO. Aalto 

Univ. Sch. of Sci. and Technol., Univ. of Helsinki. 

8:00 PPP29 415.13 Decoding temporal response patterns of 

the ocular dominance neurons from spatiotemporal pattern of 

the BOLD signal. M. MISAKI*; W. LUH; P. A. BANDETTINI. 

NIMH. 




Mon. AM


416. Molecular and Cellular Mechanisms of Memory Allocation 

in Neuronal Circuits CME 

Mon. 1:30 PM - 4:00 PM — Room 6F 

Chair: A. J. SILVA 

Co-Chair: S. A. JOSSELYN 

This symposium will review recent studies on the molecular 

and cellular mechanisms that determine how specific neurons 

and synapses within a circuit are recruited during learning 

(memory allocation). Using approaches that allow tagging, 

imaging, activation and inactivation of specific neurons in 

behaving animals, recent findings demonstrated that memory 

allocation is not random, but rather specific mechanisms 

regulate where information is stored within a neural circuit. 

Organized storage saves space, minimizes search times and 

reduces errors during retrieval. 


1:35 416.2 Neuronal competition and selection during memory 

formation. S. A. JOSSELYN. Hosp Sick Children. 

2:10 416.3 Dynamics of synaptic allocation of motor memory. Y. 

ZUO. Univ. of California Santa Cruz. 

2:45 416.4 Molecular and cellular mechanisms of emotional 

memory allocation in the lateral amygdala. A. J. SILVA. UCLA 

Med. Ctr. 

3:20 416.5 • A role for adult neurogenesis in learning and 

memory. F. H. GAGE. Salk Inst. 



417. Visceral Nociception: Bidirectional Interaction between 

the Viscera and Brain CME 

Mon. 1:30 PM - 4:00 PM — Room 6B 

Chair: M. O. FRASER 

This session will describe normal nociceptive processing 

from pelvic viscera to the spinal cord, brain stem and the 

brain and how changes along this pathway may result in 

functional pain syndromes. For most, integration of input and 

modulatory signals occurs within and between each level, 

resulting in awareness of injury until healed. In functional pain 

syndromes, anomalous interoceptive influences at one or 

more levels may cause chronic hyperalgesia even without a 

noxious stimulus. 


1:35 417.2 Nociceptive processing in the periphery. L. A. 

BIRDER. Univ. Pittsburgh Sch. Med. 

2:10 417.3 • Nociceptive processing in the spinal cord. F. 

CERVERO. McGill Univ. 

2:45 417.4 Nociceptive processing in the brain. E. A. MAYER. 

UCLA. 

3:20 417.5 Levels/mechanisms of bidirectionality. M. O. 

FRASER. Duke Univ. 



Monday PM 


418. functional Interactions Between Stress and the 

Endocannabinoid System: from Synaptic Signaling 

to Behavioral Output CME 

Mon. 1:30 PM - 4:00 PM — Room 6E 

Chair: M. N. HILL 

Co-Chair: J. S. BAINS 

Endocannabinoid signaling is an important regulator of 

transmitter release and synaptic signaling. Recent research 

has demonstrated a potentially important role for this 

system in the regulation of physiological, neuroendocrine 

and behavioural response to stress. The current 

minisynposium provides an overview of the mechanisms by 

which endocannabinoid signaling integrates into both the 

hypothalamic-pituitary-adrenal axis and the limbic structures 

subserving regulation of this neuroendocrine axis. 


1:35 418.2 Functional crosstalk between stress, glucocorticoids 

and cortico-limbic endocannabinoid signaling. M. N. HILL. The 

Rockefeller Univ. 

1:55 418.3 Glucocorticoid negative feedback and 

endocannabinoids. J. G. TASKER. Tulane Univ. 

2:15 418.4 Endocannabinoid regulation of synaptic 

transmission in the PVN. J. S. BAINS. Univ. of Calgary. 

2:35 418.5 Stress modulation of endocannabinoid signaling in 

the basolateral amygdala. S. PATEL. Vanderbilt Univ. 

2:55 418.6 Neuronal populations involved in the ability 

of endocannabinoids to modulate neuroendocrine and 

behavioral responses and adaptation to stress. C. T. 

WOTJAK. Max Planck Inst. of Psychiatry. 

3:15 418.7 Role of endocannabinoids in mediating 

glucocorticoid effects on memory consolidation. P. 

CAMPOLONGO. Univ. of Rome “La Sapienza”. 



419. Molecular Pathways Controlling Development of 

Thalamus and hypothalamus: from Neural Specification 

to Circuit formation CME 

Mon. 1:30 PM - 4:00 PM — Room 29D 

Chair: S. BLACKSHAW 

Co-Chair: T. SHIMOGORI 

The embryonic diencephalon gives rise to both the vertebrate 

thalamus and hypothalamus. Recent work has begun 

to shed light on the molecular pathways that guide the 

development of these structures. We will highlight advances 

in understanding control of early regional patterning, neuronal 

cell fate specification, and the formation and environmental 

modification of neural circuitry in both thalamus and 

hypothalamus. 


1:35 419.2 Genetic analysis of molecular pathways regulating 

early thalamic development. S. SCHOLPP. Karlsruhe Inst. of 

Technol. 

1:55 419.3 Wiring and patterning the thalamus and the cortex. 

T. SHIMOGORI. RIKEN. 



2:15 419.4 Genomic analysis of mouse hypothalamic 

development. S. BLACKSHAW. Johns Hopkins Univ, Sch. 

Med. 

2:35 419.5 Molecular mechanisms of hypothalamic patterning. 

M. PLACZEK. Univ. of Sheffield. 

2:55 419.6 Leptin-dependent control of axonal targeting in 

developing hypothalamus. R. B. SIMERLY. Childrens Hosp 

Los Angeles/USC. 

3:15 419.7 Development of neural connectivity of the 

ventromedial hypothalamic nucleus. H. A. INGRAHAM. UC 

San Francisco. 



420. The Role of Acetylcholine in Cortical Processing and 

Plasticity CME 

Mon. 1:30 PM - 4:00 PM — Room 30E 

Chair: M. A. SILVER 

Acetylcholine was the first neurotransmitter to be discovered, 

and its biochemical and cognitive effects have been intensely 

studied for several decades. This minisymposium highlights 

recent anatomical, electrophysiological, pharmacological, 

behavioral, and brain imaging studies of the functions of 

acetylcholine in the cerebral cortex. The results of these 

studies shed light on the neural mechanisms underlying 

cholinergic modulation of attention, learning, and encoding of 

sensory stimuli. 


1:35 420.2 Laminar and cell-type specific expression of 

acetylcholine receptors in macaque V1 and their impact 

on gain modulation. A. A. DISNEY. The Salk Inst. for Biol. 

Studies. 

1:55 420.3 A synaptic memory trace for cortical receptive field 

plasticity. R. C. FROEMKE. Skirball Institute, New York Univ. 

Sch. of Med. 

2:15 420.4 • Attentional functions of cortical cholinergic 

inputs: implications for the modeling and treatment of 

neuropsychiatric disorders. R. KOZAK. Pfizer. 

2:35 420.5 Interactions between acetylcholine and attention in 

visual cortex. A. THIELE. Univ. of Newcastle. 

2:55 420.6 • Nicotine-induced changes in neural networks 

supporting inhibitory control. C. M. THIEL. Univ. of Oldenburg. 

3:15 420.7 Effects of acetylcholine on visual cortex, attention, 

and learning. M. A. SILVER. Univ. of California, Berkeley. 




ALBERT AND ELLEN GRASS LECTURE 


421. Dendrites, from form to function CME 

Mon. 3:15 PM - 4:25 PM — Ballroom 20 

Speaker: L. JAN, Y.N. JAN, Univ. of California, San Francisco. 

Support contributed by The Grass Foundation 

Different types of neurons display dendrites with distinct 

branching patterns – a hallmark feature that enables neurons 

to receive and process information properly. This lecture 

will summarize what we have learned as to how dendrites 

form and organize among themselves, and how dendritic 

ion channels are regulated by synaptic activities and in turn 

modulate neuronal activity and synaptic plasticity. Implications 

to the etiology of neurological diseases and mental disorders 

will be discussed. 

PRESIDENTIAL SPECIAL LECTURE 


422. Learning to See Late in Life CME 

Mon. 5:15 PM - 6:25 PM — Ballroom 20 

Speaker: P. SINHA, Massachusetts Inst. of Technol. 

Support contributed by Pfizer, Inc. 

We open our eyes and see a world that makes sense, easily 

parsing the visual array into meaningful objects. To study 

this process, we have recently launched Project Prakash - a 

synergistic humanitarian and scientific initiative that helps 

provide sight to congenitally blind children, and characterizes 

their subsequent visual development. The effort has provided 

insights into the early stages of learning to see, while 

improving the lives of children who were otherwise doomed to 

a life of blindness. 

NANOSYMPOSIUM 

423. Postnatal Neurogenesis III 


Mon. 1:00 PM — San Diego Convention Center, Room 25A 

1:00 423.1 The hypothalamic proliferative zone: The 

identification of a novel neurogenic niche in the postnatal 

mammalian hypothalamus. D. A. LEE*; T. PAK; V. 

CHARUBHUMI; A. MIRANDA-ANGULO; H. WANG; F. 

BALORDI; G. FISHELL; S. BLACKSHAW. Johns Hopkins 

Sch. of Med., New York Univ. Sch. of Med. 

1:15 423.2 Neuronal TGF-β signaling regulates survival and 

maturation of newborn neurons in the adult dentate gyrus. 

Y. HE*; H. ZHANG; P. A. JAEGER; O. OLAYIWOLA; N. 

FAINBERG; T. WYSS-CORAY. Stanford Univ. Sch. of Med. 

1:30 423.3 Prox1 is required for granule cell maturation 

and intermediate progenitor maintenance during brain 

neurogenesis. A. J. LAVADO*; O. LAGUTIN; G. OLIVER. St 

Jude Children Resch Hosp. 

1:45 423.4 Spines of newborn granule cells are regulated by 

NMDA receptors. C. ZHAO*; Y. MU; F. H. GAGE. Salk Inst., 

Salk Inst. for Biol. Studies. 

2:00 423.5 EphB signaling controls lineage plasticity of adult 

neural stem cell niche cells. T. NOMURA*; C. GORITZ; J. 

FRISEN. Karolinska Inst. 

Neuroscience 2010 | Monday PM | 81 

Mon. PM 

NANOSYMPOSIUM

NANOSYMPOSIUM 

2:15 423.6 Zfp423 is a master transcription factor that regulates 

the proliferation and differentiation of adult neural stem cells. 

L. FLORES-GARCIA; J. RAY; W. A. ALCARAZ; C. HONG; F. 

H. GAGE; B. A. HAMILTON*. UCSD Sch. Med., Salk Inst. for 

Biol. Studies. 

2:30 423.7 An orphan nuclear receptor controls adult neural 

stem cell positioning and activation. C. ZHANG*; W. NIU; Y. 

ZOU. UT Southwestern Med. Ctr. 

2:45 423.8 Fezf2 regulates the self-renewal and differentiation 

of neural stem cells in the adult zebrafish telencephalon. M. 

A. BERBEROGLU; Z. DONG; T. MUELLER; S. GUO*. Univ. 

California - San Francisco. 

3:00 423.9 Adult hippocampal neurogenesis and behaviour 

are altered by diet in mice. What is the role of Klotho? D. 

STANGL*; B. MORISSE; S. AHMET; L. J. AIMONE; J. B. 

AIMONE; F. H. GAGE; S. THURET. King’s Col. London, Salk 

Inst. for Biol. Studies. 

3:15 423.10 Role of SoxC transcription factors in adult 

hippocampal neurogenesis. L. BERTI; M. COVIC; L. MU; 

A. HASLINGER; V. LEFEBVRE; M. WEGNER; E. SOCK*; 

D. C. LIE. Helmholtz Ctr. Munich, Lerner Res. Inst., Univ. of 

Erlangen. 

3:30 423.11 Subpopulations of radial-glia like cells may 

differentially contribute to adult neurogenesis in the 

hippocampus in vivo. N. A. DECAROLIS*; M. MECHANIC; D. 

PETRIK; S. MALHOTRA; J. L. ABLES; D. C. LAGACE; A. J. 

EISCH. UT-Southwestern Med., Univ. of Ottowa. 

3:45 423.12 Maintenance of neural stem cells requires dynamin. 

J. J. BREUNIG*; J. I. ARELLANO; K. ANIGHORO; S. 

FERGUSON; P. DE CAMILLI; P. RAKIC. Yale Univ. Sch. Med. 

4:00 423.13 Specific labeling and noninvasive imaging of adult 

endogenous neural stem cells using conditional viral vectors. 

V. REUMERS*; R. GIJSBERS; A. IBRAHIMI; S. AELVOET; S. 

DE SWAEF; I. THIRY; C. VAN DEN HAUTE; Z. DEBYSER; V. 

BAEKELANDT. Katholieke Univ. Leuven. 

NANOSYMPOSIUM 

424. Dementia Molecular Genetics and Proteome 


Mon. 1:00 PM — San Diego Convention Center, Room 32B 

1:00 424.1 Role of specific microRNAs in regulating neuronal 

genes implicated in Alzheimer’s disease. J. M. LONG*; D. K. 

LAHIRI. Indiana Univ. Sch. of Med. 

1:15 424.2 Solution NMR studies of transmembrane domain of 

APP. C. WANG*; W. CHEN; Y. LI; E. GAMACHE. Rensselaer 

Polytech Inst., MSKCC. 

1:30 424.3 • Gene expression profiling of choroid plexus in 

Alzheimer’s disease reveals important implications of 

csf dynamics. E. G. STOPA*; E. V. NIKONOVA; A. A. 

PODTELEZHNIKOV; K. Q. TANIS; E. M. FINNEY; D. J. 

STONE; L. M. CAMARGO; L. PARKER; A. VERMA; A. 

BAIRD; M. C. MILLER; J. E. DONAHUE; A. GONZALEZ; 

B. ELICEIRI; G. D. SILVERBERG; P. M. KLINGE; C. E. 

JOHANSON. Brown Univ., Merck & Co, Inc., Univ. of 

California San Diego Med. Ctr., Univ. of Birmingham. 

1:45 424.4 • The proteostasis network in age-associated 

neurodegenerative diseases. H. GE*; L. WANG; Y. ZHU; K. 

BAILEY; F. USECHE; W. BALCH; A. DILLIN; R. MORIMOTO; 

W. NEWMAN; P. REINHART. Proteostasis Therapeut. Inc, 

The Scripps Res. Inst., The Salk Inst. for Biol. Studies, 



2:00 424.5 • Role of the amyloid β-peptide as a transcription 

factor and Its implication in Alzheimer’s disease. D. K. 

LAHIRI*; B. MALONEY; Y. GE; J. A. BAILEY. Indiana Univ. 

Sch. of Med. 

NANOSYMPOSIUM 

425. huntington’s Disease: Animal Models I 


Mon. 1:00 PM — San Diego Convention Center, Room 10 

1:00 425.1 • Dominant negative tumor necrosis factor 

gene delivery in the yac128 transgenic mouse model of 

Huntington’s disease. M. G. TANSEY*; L. A. TAYLOR; X. 

CHEN; I. TREVINO; K. RUHN. Emory Univ. Sch. of Med., UT 

Southwestern. 

1:15 425.2 Huntingtin expression prevents the development 

of epilepsy in FVB/N mice by reducing seizure-induced 

neurodegeneration. B. LEAVITT*; J. M. VAN RAAMSDONK; 

L. WAGNER; T. W. BREDY; J. PEARSON; C. SCHWAB; 

Z. MURPHY; R. S. DEVON; G. LU; M. S. KOBOR; M. R. 

HAYDEN. Ctr. For Mol. Med. & Therapeut., Queensland Brain 

Institute, Univ. of Queensland, Univ. of Edinburgh Mol. Med. 

Ctr. 

1:30 425.3 Neuroprotective effects of mycophenol in an 

inducible cell model and the N171-82Q mouse model of 

Huntington’s disease. N. ARBEZ*; Q. PENG; Y. CHENG; 

Q. LI; J. FU; S. BHAT; J. LIU; T. ELLIS; M. JOYNER; R. H. 

CICHEWICZ; W. DUAN; C. A. ROSS. Johns Hopkins Univ., 

Univ. of Oklahoma. 

1:45 425.4 Transgenic HD mouse model expressing the 

putative caspase 6 derived huntingin fragment. E. A. 

WALDRON*; T. RATOVITSKI; E. CHIGHLADZE; A. T. 

TEBBENKAMP; R. K. GRAHAM; M. R. HAYDEN; D. R. 

BORCHELT; C. A. ROSS. Johns Hopkins Univ., McKnight 

Brain Inst., Univ. of British Columbia. 

2:00 425.5 Increased epigenetic histone acetylation in postmortem 

Huntington’s disease brain. P. J. NARAYAN*; C. A. 

MCLEAN; A. SHEPPARD; R. L. M. FAULL; M. DRAGUNOW. 

Univ. of Auckland, Liggins Inst. 

2:15 425.6 The search for Huntington’s disease modifier genes 

using random mutagenesis in mice. S. CORROCHANO*; A. 

ACEVEDO-AROCENA; S. CARTER; D. C. RUBINSZTEIN; S. 

D. M. BROWN. Med. Res. Council, Addenbrooke’s Hosp. 

2:30 425.7 Nicotinamide improves motor deficits and 

upregulates PGC-1α and BDNF gene expression in a mouse 

model of Huntington’s disease. T. HATHORN; A. SNYDER- 

KELLER; A. MESSER*. Albany Med. Col., New York State 

Dept Hlth., Univ. at Albany. 

2:45 425.8 Longitudinal brain volumetric changes measured by 

structural MRI in preclinical studies of Huntington’s disease 

mouse models. Y. CHENG; Z. HOU; Q. PENG; J. ZHANG; S. 

MORI; C. A. ROSS; W. DUAN*. Johns Hopkins Univ. 



NANOSYMPOSIUM 

426. Genetic Epilepsies 



1:00 426.1 Identification of epilepsy susceptibility loci by 

convergence of genome wide association and copy number 

variation data sets. R. J. BUONO*; I. HELBIG; H. ZHANG; 

K. WANG; F. LOHOFF; W. BERRETTINI; T. FERRARO; H. 

HAKONARSON. DVA, Christian-Albrechts Univ. of Kiel and 

Univ. Med. Ctr. Schleswig-Holstein,, The Children’s Hosp. of 

Philadelphia, Univ. of Pennsylvania. 

1:15 426.2 Loss-of-function scn1a mutations associated with 

gefs+ and sudep. Y. LIAO*; H. KERTI; L. SÁEZ-HERNÁNDEZ; 

E. GUTIÉRREZ-DELICADO; N. PÉREZ-CASTELLANO; 

M. GARCÍA-TORRENT; J. VILLACAST; J. MACARRÓN2; 

R. SANZ; R. GUERRERO; B. GIRALDEZ; H. LERCHE; J. 

SERRATOSA. Dept. of Neurol. and Epileptology Hertie Inst. 

of Clin. Brain Research,, Neurol. Service, Fundacion Jimenez 

Diaz and Ctr. for Biomed. Res. in Rare Dis. (CIBERER). 

1:30 426.3 • The role of Lis1 and Ndel1 in dynein-mediated 

retrograde transport in mature neurons. J. P. PANDEY*; M. T. 

MESNGON; S. HEBBAR; D. S. SMITH. Univ. South Carolina, 

United States Army. 

1:45 426.4 BC1 RNA and FMRP counterbalance the mGluR- 

MAPK translation pathway in brain. J. ZHONG*; S. CHUANG; 

R. BIANCHI; W. ZHAO; G. PAUL; P. THAKKAR; A. A. 

FENTON; R. K. S. WONG; H. TIEDGE. State Univ. of New 

York Hlth. Sci. Ctr. At Brooklyn, State Univ. of New York Hlth. 

Sci. Ctr. at Brooklyn, New York Univ. 

2:00 426.5 Epigenetic regulation of the NR2B gene in an 

experimental epilepsy model. R. R. PARRISH; F. D. LUBIN*. 

Univ. Alabama Birmingham. 

2:15 426.6 Diffusion tensor imaging in absence epilepsy. A. 

M. MISHRA*; D. COMAN; N. DANIELSON; C. BASHYAL; 

M. COQUILLETTE; M. NEGISHI; M. VESTAL; B. KILLORY; 

T. VAN RIJN; P. M. EDELBROEK; R. T. CONSTABLE; F. 

HYDER; G. E. J. M. VAN LUIJTELAAR; H. BLUMENFELD. 

Yale Univ. Sch. Med., Yale Univ. Sch. Med, NEW HAVEN, 

CT, United States, Donders Inst. for Brain, Cognition and 

Behaviour, Stichting Epilepsie Instellingen Nederland. 

2:30 426.7 Cluster analysis of fMRI data in typical childhood 

absence seizures. X. BAI*; B. KILLORY; J. GUO; M. VESTAL; 

R. BERMAN; M. NEGISHI; E. NOVOTNY; R. CONSTABLE; 

H. BLUMENFELD. Yale Sch. of Med. 

2:45 426.8 Variability in attention performance and fMRI 

signal changes during typical childhood absence seizures. 

J. N. GUO*; N. B. DANIELSON; B. D. KILLORY; X. BAI; M. 

NEGISHI; M. VESTAL; R. BERMAN; C. VEGA; M. SPANN; 

E. J. NOVOTNY; R. T. CONSTABLE; H. BLUMENFELD. Yale 

Univ. 

3:00 426.9 Impaired attention and network connectivity in 

childhood absence epilepsy. B. D. KILLORY; X. BAI; M. 

NEGISHI; C. VEGA; M. SPANN; M. VESTAL; R. BERMAN; 

N. DANIELSON; J. GUO; S. FOOTE; C. MCAULIFFE; E. 

J. NOVOTNY, Jr.; R. T. CONSTABLE; H. BLUMENFELD*. 

Barrow Neurolog. Institute, St. Joseph’s Hosp., Yale Univ. 

Sch. Med. 

3:15 426.10 Effects of a mutation in the GABAA receptor β3 

subunit associated with childhood absence epilepsy. K. 

N. GURBA*; C. C. HERNANDEZ; N. HU; W. LO; R. L. 

MACDONALD. Vanderbilt Univ. 



3:30 426.11 The nonsense mutation GABRG2(Q40X) 

decreased mRNA and altered GABA A receptor assembly 

and trafficking and was rescued by gentamicin-induced stopcodon 

readthrough. X. HUANG*; J. TOPLON; N. HU; R. 

MACDONALD; M. TIAN. Vanderbilt Univ. 

3:45 426.12 The intronic mutation, ivs6+2t->g, associated with 

cae altered gabrg2 mrna intron splicing and generated stable 

mutant gabaa receptor Γ2 subunits that altered assembly 

and trafficking and induced cellular stress. M. TIAN*; R. 

MACDONALD. Vanderbilt Univ. Med. Ctr. 

NANOSYMPOSIUM 

427. Neuroinflammation and CNS Injury 


Mon. 1:00 PM — San Diego Convention Center, Room 31C 

1:00 427.1 Involvement of the IL-1 system in neutrophil 

and proinflammatory monocyte recruitment after SCI. D. 

BASTIEN; N. VALLIÈRES; N. FORTIN; S. LACROIX*. Univ. 

Laval. 

1:15 427.2 CD4+ T cells induce alternatively activated microglia 

in the mSOD1 mouse model of ALS. J. S. HENKEL*; D. 

R. BEERS; B. LIAO; W. ZHAO; S. H. APPEL. Methodist 

Neurolog Inst. 

1:30 427.3 The pro-inflammatory role of eph receptors following 

spinal cord injury. S. J. GLASS*; Z. ZHUANG; M. H. THEUS; 

D. J. LIEBL. Univ. of Miami. 

1:45 427.4 P2X4 receptor regulates inflammasome activation 

following injury to the spinal cord. J. P. DE RIVERO 

VACCARI*; G. YURCISIN; W. DIETRICH; Y. DE KONINCK; D. 

BASTIEN; S. LACROIX; R. KEANE. Univ. Miami Sch. Med., 

Ctr. de Recherche Univ. Laval Robert-Giffard, Univ. Laval,, 

Univ. of Miami. 

2:00 427.5 Activating toll-like receptor 2 promotes macrophagemediated 

regeneration without concurrent neurotoxicity. J. C. 

GENSEL*; K. A. BECKWITH; P. G. POPOVICH. The Ohio 

State Univ. Col. of Medicine, Ctr. For Brain and Spinal Cord, 

The Ohio State Univ. Col. of Med. 

2:15 427.6 Thrombospondin-1 is detrimental to neuronal 

survival in acute CNS injury: The immune link. J. WALSH*; J. 

KIPNIS. Univ. of Virginia. 

2:30 427.7 Elucidating the role of microglia in secondary 

degeneration following spinal cord injury in real-time using 

two-photon microscopy. D. P. STIRLING*; K. A. CUMMINS; P. 

K. STYS. Hotchkiss Brain Institute/ Univ. of Calgary. 

2:45 427.8 Role of inflammatory mediators in stimulating optic 

nerve regeneration. L. I. BENOWITZ*; T. KURIMOTO; S. 

NAKAO; G. HABBOUB; H. GILBERT; K. OMURA; Y. YIN; A. 

HAFEZI-MOGHADAM. Children’s Hosp/Harvard Med. Sc, 

Massachusetts Eye and Ear Infirmary, Harvard Med, Sch. 

3:00 427.9 CCL21 is neither sufficient nor necessary for 

lymphocytic influx into the CNS, but does direct T cell 

localization during early Toxoplasma gondii infection of the 

CNS. S. NOOR; D. D. LO; E. H. WILSON; M. J. CARSON*. 

Univ. of California Riverside. 

3:15 427.10 The role of regulatory T lymphocytes in neuronal 

survival after CNS injury. J. KIPNIS*; J. T. WALSH. Univ. 

Virginia, Univ. of Virginia. 

3:30 427.11 Oligodendrocyte-sequestered antigens lead to T cell 

recruitment to the CNS. M. G. HARRIS*; B. CLARKSON; C. 

LING; J. KARMAN; M. SANDOR; Z. FABRY. Univ. Wisconsin. 


Mon. PM 

NANOSYMPOSIUM

NANOSYMPOSIUM 

3:45 427.12 The effects of CD4 + CD25 + regulatory T cells on 

microglia in a mouse model of inherited ALS. W. ZHAO; D. 

BEERS; J. HENKEL; B. LIAO; S. H. APPEL*. Methodist 

Neurol Inst. 

4:00 427.13 Oncomodulin links intraocular inflammation to optic 

nerve regeneration. Y. YIN*; H. GILBERT; T. KURIMOTO; L. I. 

BENOWITZ. F.M. Kirby Neurobio. Center, Children’s Hospital, 


NANOSYMPOSIUM 

428. Neurotoxicity and Neurodegeneration IV 



1:00 428.1 • Metal chelators coupled with nanoparticles as 

potential therapeutic agents for Alzheimer’s disease. M. A. 

SMITH; G. LIU; P. MEN; X. ZHU; R. J. CASTELLANI; G. 

PERRY*. Case Western Reserve Univ., Univ. of Utah, Univ. of 

Maryland, The Univ. of Texas At San Antonio. 

1:15 428.2 Engineered nanoparticles from metals induce 

upregulation of nitric oxide and exacerbate pathophysiology 

of spinal cord injury in the rat. L. FENG*; A. SHARMA; H. S. 

SHARMA. Bethune Intl. Peace Hosp., Univ. Hopital, Uppsala 

Univ. 

1:30 428.3 Cerebrolysin treatment reduces oxidative 

stress and pathophysiology of brain injury caused by 

engineered nanoparticles following heat stress in the 

rat. D. F. MURESANU*; R. PATNAIK; A. SHARMA; H. 

SHARMA. ROMANIAN SOCIETY FOR THE STUDY OF 

NEUROPROTECTION AND NEUROPLASTICITY, Sch. 

of Biomed. Engineering, Inst. of technology, Univ. Hopital, 

Uppsala Univ. 

1:45 428.4 Peptide-engineered polylactide-co-glycolide (PLGA) 

nanoparticles for brain delivery of drugs: In vivo experiments 

and proof of concept. G. TOSI*; R. A. FANO; L. BADIALI; L. 

BONDIOLI; B. RUOZI; A. VERGONI; F. RIVASI; R. BENASSI; 

M. VANDELLI; F. FORNI. Te.far.t.i., Dept. of Pharmaceut. 

Sciences, Univ. of Modena and Reg, Univ. of Modena and 

Reggio Emilia. 

2:00 428.5 Age-dependent upregulation of neuronal nitric 

oxide synthase, heat shock protein 72 kD responses 

and neurotoxicity following acute methamphetamine 

administration. J. V. LAFUENTE*; R. PATNAIK; A. SHARMA; 

H. S. SHARMA. Univ. of Basque Country, Uppsala Univ., Sch. 

of Biomed. Engineering, Banaras Hindu Univ. 

2:15 428.6 Diabetes aggravates brain pathology caused by 

SiO2 nanoparticles exposure. H. S. SHARMA*; R. PATNAIK; 

A. SHARMA. Uppsala Univ., Inst. of Technology, Banaras 

Hindu Univ., Univ. Hopital, Uppsala Univ. 

2:30 428.7 Iron overload and melanin systems in the retina - a 

new mechanism for retinal degeneration? A. E. MILWARD*; 

S. HOLLINS; R. GRAHAM; M. VAN BALEN; D. TRINDER; 

M. CAIRNS; D. JOHNSTONE. Univ. of Newcastle, Univ. of 

Western Australia. 

2:45 428.8 Inhalation of diesel engine exhaust and 

neuroinflammation. A. G. CAMPBELL*; F. CASSEE; M. 

GERLOFS-NIJLAND. Western Univ. Hlth. Sci., Natl. Inst. for 

Publ. Hlth. and the Envrn. 


NANOSYMPOSIUM 

429. Visual Cognition: Attentional Modulation of Neuronal and 

Network Activity 



1:00 429.1 Top-down modulation of bottom-up stimulus 

competition in the owl optic tectum. S. P. MYSORE*; E. I. 

KNUDSEN. Stanford Univ. 

1:15 429.2 Attention-gated spatial coding in the human pulvinar 

is tied to functional connectivity in visual cortex. J. FISCHER*; 

D. WHITNEY. UC Berkeley. 

1:30 429.3 Automatic spread of attentional response 

modulation according to Gestalt criteria in primary visual 

cortex. P. R. ROELFSEMA*; L. STANISOR; A. WANNIG. 

Netherlands Inst. for Neurosci., Ctr. for Neurogenomics and 

Cognitive Research, VU Univ. Amsterdam. 

1:45 429.4 Unmasking the contribution of low-level features 

to the guidance of attention. J. P. OSSANDON*; S. ONAT; 

D. CAZZOLI; T. NYFFELER; R. MÜRI; P. KÖNIG. Inst. Für 

Kognitionswissenschaft, Univ. Osnabrück, Perception and 

Eye Movement Laboratory, Dept. of Neurology, Dept. of Clin. 

Research, Bern Univ. Hosp. Inselspital, and Univ. of Bern. 

2:00 429.5 Cortical attentional field maps for individual visual 

areas from V1 to V7. A. M. PUCKETT*; E. A. DEYOE; J. R. 

MATHIS. Med. Col. Wisconsin, Med. Col. of Wisconsin. 

2:15 429.6 Eye-position dependent functional connection 

from somatosensory to visual cortex involved in visuospatial 

attention. D. BALSLEV*; F. Å. NIELSEN; T. KASSUBA. 

Copenhagen Univ. Hosp., Tech. Univ. of Denmark. 

2:30 429.7 Cholinergic influence on attentional modulation 

in extrastriate cortex of the rhesus monkey. M. A. 

GIESELMANN*; A. THIELE. Newcastle Univ. 

2:45 429.8 Spatial attention affects perceived stimulus position. 

P. BINDA*; C. MORRONE; S. O. MURRAY; G. M. BOYNTON. 

Universita’ Vita-Salute San Raffaele, IIT, Univ. di Pisa, 

Scientific Inst. Stella Maris, Calambrone, Univ. of Washington. 

3:00 429.9 Anticipatory climbing activity present in the local 

field potential but not in spike rates in macaque area LIP. P. 

JANSSEN*; W. VANDUFFEL; E. PREMEREUR. KU Leuven. 

3:15 429.10 Frontal eye field microstimulation modulates local 

field potential power in macaque area LIP. E. PREMEREUR*; 

W. VANDUFFEL; P. R. ROELFSEMA; P. JANSSEN. 

K.U.Leuven, Massachusetts Gen. Hosp., Harvard Med. Sch., 

Netherlands Inst. for Neurosci. 

3:30 429.11 A network model of multiplicative attention 

modulation. S. MIHALAS*; E. NIEBUR. Johns Hopkins Univ. 

NANOSYMPOSIUM 

430. TRP Channels and Pain Transduction 


Mon. 1:00 PM — San Diego Convention Center, Room 33C 

1:00 430.1 TRPA1 is required for Chloroquine-evoked itch. S. 

WILSON*; D. M. BAUTISTA; A. BIFOLCK-FISHER; X. DONG; 

Q. LIU. Univ. of California, Berkeley, Johns Hopkins. 

1:15 430.2 • TRPA1-associated proteins and their role in 

nociception. M. SCHMIDT*; E. C. PETERS; A. E. DUBIN; T. 

J. EARLEY; M. J. PETRUS; A. PATAPOUTIAN. The Scripps 

Res. Inst., Genomics Inst. of the Novartis Res. Fndn. 



1:30 430.3 • TRPA1 is a key contributor to cold hypersensitivity. 

M. M. MORAN*; S. MURPHY; M. HEIRY; L. BARRETT; 

T. J. EARLEY; C. A. COOK; M. J. PETRUS; M. ZHAO; M. 

D’AMOURS; N. DEERING; G. J. BRENNER; M. COSTIGAN; 

J. A. CHONG; N. J. HAYWARD; C. M. FANGER; A. ARDEM 

PATAPOUTIAN; C. J. WOOLF; D. DEL CAMINO. Hydra 

Biosci., Children’s Hosp. Boston, The Scripps Res. Inst., 

Genomics Inst. of the Novartis Res. Fndn., Massachusetts 

Gen. Hosp. 

1:45 430.4 TRPM8, but not TRPA1, is required for neural and 

behavioral responses to acute noxious cold temperatures 

and cold-mimetics in vivo. W. M. KNOWLTON*; A. FISHER; 

D. M. BAUTISTA; D. D. MCKEMY. USC, Univ. of California, 

Berkeley. 

2:00 430.5 Pore turret is part of the temperature-sensing 

structure of thermoTRP channels. F. YANG; Y. CUI; X. CAO; 

K. WANG; J. ZHENG*. Univ. of California at Davis, Peking 

Univ. Hlth. Sci. Ctr. 

2:15 430.6 Ciliary neurotrophic factor regulates 

thermoreceptors of the transient receptor potential family and 

modulates thermoception and nociception. M. LETELLIER*; 

J. WALCZAK; S. CRABÉ; M. GINGRAS; A. J. TORMO; F. 

BERTHOD; G. ELSON; P. BEAULIEU; J. GAUCHAT. Univ. De 

Montréal, LOEX, Univ. Laval, NovImmune. 

2:30 430.7 The role of phosphoinositides in the desensitization 

of TRPM8 currents. T. ROHACS*; Y. YUDIN; E. ZAKHARIAN; 

V. LUKACS. UMDNJ, New Jersey Med. Sch. 

NANOSYMPOSIUM 

431. Receptors: Cellular and Molecular Mechanisms of 

Transduction 



1:00 431.1 Using in vivo structure-function analysis to reveal 

how force activates the MEC-4 channel responsible for 

touch sensation in C. elegans. A. L. EASTWOOD; M. B. 

GOODMAN*. MCP/Stanford Univ. 

1:15 431.2 Ion channel contributions to auditory 

mechanosensation in Drosophila melanogaster. J. C. 

CALDWELL*; J. JACOBS; E. SIVAN-LOUKIANOVA; D. F. 

EBERL; W. D. TRACEY, Jr. Duke Univ. Med. Ctr., Univ. of 

Iowa. 

1:30 431.3 TRPA1 mediates mechanical currents in the plasma 

membrane of mouse sensory neurons. D. VILCEANU*; C. L. 

STUCKY. Med. Col. of Wisconsin. 

1:45 431.4 The star-nose mole as a model system for 

studying molecular mechanisms of mechanotransduction. K. 

GERHOLD*; T. MORITA; D. B. LEITCH; K. CATANIA; D. M. 

BAUTISTA. Univ. of California, Berkeley, Vanderbilt Univ. 

2:00 431.5 Tingling alkylamides target distinct subsets of 

mechanosensitive somatosensory neurons. M. TSUNOZAKI*; 

R. C. LENNERTZ; C. L. STUCKY; D. M. BAUTISTA. UC 

Berkeley, Med. Col. of Wisconsin. 

2:15 431.6 Generation of Cav3.2 reporter mice to characterize 

ultrasensitive skin mechanoreceptors. Y. ANDREA-BERNAL- 

SIERRA; A. KOZLENKOV; G. R. LEWIN*. Max-delbruck- 

Center For Mol. Med. 

2:30 431.7 Touché: A recessive zebrafish mutation 

which abolishes generator potentials in cutaneous 

mechanoreceptors. S. E. LOW; J. RYAN; M. LACHANCE; L. 

SAINT-AMANT*. Univ. De Montréal. 



2:45 431.8 Structural determinants of tip-link-cadherin function 

in hearing and deafness. M. SOTOMAYOR; W. WEIHOFEN; 

R. GAUDET; D. P. COREY*. Harvard Med. Sch., Harvard 

Univ. 

3:00 431.9 • DEG/ENaC and TRP channels have distinct roles 

in C. elegans mechanonociception. S. L. GEFFENEY*; 

J. G. CUEVA; D. A. GLAUSER; J. C. DOLL; T. H. LEE; 

M. MONTOYA; S. KARANIA; A. NAIM; A. GARAKANI; B. 

PRUITT; M. B. GOODMAN. Stanford Univ. Sch. Med., Reify 

Corp. 

NANOSYMPOSIUM 

432. Mechanisms and Physiological factors that Regulate 

Sleep 



1:00 432.1 Neural pathways are responsible for relaying the 

direct effects of light to the sleep and alertness system. 

J. HUBBARD; E. RUPPERT; J. TSAI; J. HANNIBAL; G. 

HAGIWARA; D. COLAS; B. F. O’HARA*; H. C. HELLER; P. 

FRANKEN; P. BOURGIN. Univ. of Strasbourg, Stanford Univ., 

Rigshopitalet, Univ. Kentucky, Univ. of Lausanne. 

1:15 432.2 Role of melanopsin in sleep regulation: The direct 

effects of light interact with the circadian and homeostatic 

drive. P. BOURGIN; J. TSAI; E. RUPPERT; J. HUBBARD; J. 

HANNIBAL; G. HAGIWARA; D. COLAS; N. F. RUBY*; H. C. 

HELLER; P. FRANKEN. Univ. of Strasbourg, Stanford Univ., 

Rigshopitalet, Univ. of Lausanne. 

1:30 432.3 Slow wave sleep is preferentially regulated during 

sleep fragmentation in mice. R. VIJAY*; N. KAUSHAL; D. 

GOZAL. Univ. of Chicago. 

1:45 432.4 Protein levels of the GABA A receptor β1 subunit and 

GABA precursor, GAD, are increased in the perifornical region 

of the posterior hypothalamus following sleep deprivation. D. 

V. VOLGIN; G. M. STETTNER; R. J. ROSS*; L. KUBIN. Univ. 

of Pennsylvania, Univ. Pennsylvania Sch. Med., Philadelphia 

VA Med. Ctr. 

2:00 432.5 Increased pain perception and attenuated opioid 

anti-nociception is associated with a reduced tyrosine 

hydroxylase staining in periaqueductal grey matter in 

paradoxical sleep deprived rats. G. O. SKINNER*; F. 

DAMASCENO; O. M. M. S. ALMEIDA. Univ. Do Estado Do 

Rio De Janeiro - UERJ/Centro Biomédico. 

2:15 432.6 Nicotinamide adenine dinucleotide phosphate 

diaphorase (NADPH-d) activity in dorsolateral periaqueductal 

gray matter of hyperalgesic paradoxical sleep deprived rats. F. 

DAMASCENO*; G. D. SKINNER; P. C. ARAÚJO; O. M. M. S. 

ALMEIDA. UERJ - IBRAG/Centro Biomédico. 

2:30 432.7 Identification and validation of NTSR1 as a 

candidate gene for affect and sleep. K. MRAZEK*; M. HOTZ 

VITATERNA; C. OLKER; J. MILLSTEIN; A. L. GOTTER; C. J. 

WINROW; J. J. RENGER; F. W. TUREK. Northwestern Univ., 

Sage Bionetworks, Merck Res. Labs. 

2:45 432.8 Identification of genes regulating the Sleep-Feeding 

conflict in Drosophila. A. C. KEENE*; E. R. DUBOUE; D. M. 

MCDONALD; J. BLAU. New York Univ. 

3:00 432.9 The role of casein kinase 1 epsilon (CK1ε) in mouse 

sleep. L. ZHOU*; M. VITATERNA; A. LOUDON; F. TUREK. 

Northwestern Univ., Univ. of Manchester. 


Mon. PM 

NANOSYMPOSIUM

NANOSYMPOSIUM 

3:15 432.10 App imbalance causes sleep disturbances in a 

genetic model of Down syndrome. D. COLAS*; B. CHULUUN; 

G. C. HAGIWARA; C. GARNER; C. HELLER. Stanford Univ. 

3:30 432.11 Spontaneous brain rhythms predict sleep stability in 

the face of noise. T. DANG-VU*; S. MCKINNEY; O. BUXTON; 

J. SOLET; J. ELLENBOGEN. Massachusetts Gen. Hospital, 

Harvard Med. Sch., Brigham and Women’s Hospital, Harvard 

Med. Sch., Cambridge Hlth. Alliance, Harvard Med. Sch. 

3:45 432.12 Reduced cortical thickness with depressive 

symptoms in patients with obstructive sleep apnea. P. M. 

MACEY*; A. S. MOYADI; R. KUMAR; M. A. WOO; R. M. 

HARPER. UCLA Sch. of Nursing. 

4:00 432.13 Two-dimensional mapping of EEG states for higher 

resolution sleep scoring. B. LOPOUR*; S. TASOGLU; H. E. 

KIRSCH; J. W. SLEIGH; A. J. SZERI. Univ. of California - Los 

Angeles, Univ. of California - Berkeley, Univ. of California - 

San Francisco, Waikato Clin. Sch. 

NANOSYMPOSIUM 

433. Reward and Ultrasonic Vocalization 


Mon. 1:00 PM — San Diego Convention Center, Room 2 

1:00 433.1 A subtype analysis of amphetamine-induced 

50-kHz ultrasonic vocalizations in adult rats: Effects of 

dopaminergic and noradrenergic drugs. J. WRIGHT*; M. R. S. 

DOBOSIEWICZ; P. B. S. CLARKE. McGill Univ. 

1:15 433.2 Rat 50-kHz calls in anticipation of food reward. R. 

K. SCHWARTING*; J. C. BRENES. Philipps-University of 

Marburg. 

1:30 433.3 Drug-free weekends enhance cocaine and cueassociated 

ultrasonic vocalizations. C. L. DUVAUCHELLE*; 

M. I. ABDALLA; N. H. THAKORE; T. SCHALLERT; E. Y. 

MAIER. Univ. Texas at Austin. 

1:45 433.4 Ultrasonic communication in rats: Effects of 

nucleus accumbens ibotenic acid lesion on the production of 

ultrasonic vocalizations and social approach behavior? M. C. 

CARVALHO; M. L. BRANDÃO; R. K. W. SCHWARTING; M. 

WÖHR*. Philipps-University of Marburg, Univ. of São Paulo. 

2:00 433.5 50-kHz ultrasonic vocalization in response to firsttime 

amphetamine exposure predicts the development of predrug 

anticipatory vocalization. A. AHRENS*; C. NOBILE; C. L. 

DUVAUCHELLE; T. SCHALLERT. Univ. of Texas. 

2:15 433.6 Ultrasonic vocalizations as a measure of affective 

state during cocaine and sucrose self-administration in rats. J. 

R. BROWNING; D. A. BROWNING; A. MAXWELL; Y. DONG; 

H. T. JANSEN; J. PANKSEPP; B. A. SORG*. Washington 

State Univ. 

2:30 433.7 Ultrasonic vocalizations reveal changes in emotional 

impact of cocaine and experience. E. Y. MAIER*; M. I. 

ABDALLA; T. J. SCHALLERT; C. L. DUVAUCHELLE. The 

Univ. of Texas. 

2:45 433.8 Drug evoked ultrasonic vocalizations are dependent 

on social context in the monogamous prairie vole. S. T. MA*; 

S. L. HARKEY; A. BALEN; A. ZALZALA; B. ARAGONA. Univ. 

of Michigan. 


NANOSYMPOSIUM 

434. Optical Approaches to Explore the Nervous System 



1:00 434.1 Light-activated neuronal silencing with a 

photolysable unnatural amino acid-incorporated inward 

rectifying potassium channel Kir2.1. J. KANG*; L. WANG. Salk 

Inst. 

1:15 434.2 Novel tools to expand optogenetic avenues. S. 

KLEINLOGEL*; P. WOOD; R. DEMPSKI; U. TERPITZ; K. 

FELDBAUER; C. BAMANN; E. BAMBERG. Max-Planck- 

Institute of Biophysics, Worcester Polytechnic Inst. 

1:30 434.3 Shedding light on brain mitochondrial function 

in vivo under systemic or local oxygen deficiency. A. 

MAYEVSKY*; E. BARBIRO-MICHAELY; M. MANDELBAUM- 

LIVNAT; A. LIVNAT. Bar-Ilan Univ. 

1:45 434.4 Real-time in vivo monitoring of PKA activity in deep 

brain regions using fibered fluorescence microscopy with dual 

emission detection. M. BARBOSA-BRITO; L. CAVELLINI; J. 

ZHANG; D. PAUPARDIN-TRITSCH; P. VINCENT*. CNRS 

UPMC, UMR 7102, Johns Hopkins Sch. of Med. 

2:00 434.5 Connecting brain and skin - Light tissue interaction 

in the near infrared spectrum studied with principal component 

analysis. J. KAINERSTORFER*; J. D. RILEY; F. AMYOT; 

L. NAJAFIZADEH; A. MEDVEDEV; E. WASSERMANN; J. 

GRAFMAN; A. H. GANDJBAKHCHE. NIH, Henry M. Jackson 

Fndn., Georgetown Univ. 

2:15 434.6 • Automated image capture and analysis of brdu 

labeled cells in rat brain sections. L. S. BLEICHER*; C. 

BARLOW; T. A. CARTER; A. R. DEARIE; K. EUM; B. T. 

FRANCHINI; E. K. HOFER; D. H. LEE; K. I. LORRAIN; J. C. 

PIRES; J. J. RODRIGUEZ; M. D. SAXE; B. S. STOVEKEN; P. 

C. WEDEL. BrainCells Inc. 

2:30 434.7 Spike engineering with ChR2. N. GROSSMAN*; 

R. BERLINGUER PALMINI; K. NIKOLIC; M. GRUBB; J. 

BURRONE; P. DEGENAAR. Imperial Col., King’s Col. 

POSTER 

435. Proliferation III 


Mon. 1:00 PM — San Diego Convention Center, Halls B-H 

1:00 A1 435.1 • Cortical neural precursors inhibit their 

own differentiation via N-cadherin maintenance of betacatenin 

signaling. J. ZHANG*; J. R. ADKINS; A. CHENN. 

Northwestern University. 

2:00 A2 435.2 Postnatal maternal fluoxetine effects on 

hippocampal neurogenesis and depressive-like behavior in 

prenatally stressed adolescent offspring. I. RAYEN*; D. L. 

VAN DEN HOVE; J. PRICKAERTS; H. W. M. STEINBUSCH; 

J. L. PAWLUSKI. Maastricht Univ. 

3:00 A3 435.3 Environmental enrichment influences 

the cell cycle rate and number of neuronal stem cells in the 

crayfish brain. N. AYUB; J. L. BENTON; Y. ZHANG; B. S. 

BELTZ*. Wellesley Col. 

4:00 A4 435.4 Prenatal cocaine exposure affects GABA 

neuron development in the cingulate cortex. D. M. MC 

CARTHY*; P. G. BHIDE. Mass Gen. Hosp. 



1:00 A5 435.5 Phosphorylation by Cdk1 regulates the 

function of Nde1 in neural progenitor cell cycle progression. C. 

J. EMERY*; Y. FENG. Northwestern Univ. 

2:00 A6 435.6 TRPC channel mediated neurogenesis. J. 

BROWN*; P. LEITER; N. GERGES. Med. Col, Wisconsin. 

3:00 A7 435.7 Area-specific dynamics of proliferation and 

migration during primate corticogenesis: Role of the modular 

protein p27 kip1 . E. GAUTIER*; S. PFISTER; V. CORTAY; M. 

BÉTIZEAU; N. DOERFLINGER; D. PATTI; R. DOUGLAS; 

H. KENNEDY; C. DEHAY. Stem Cell and Brain Res. 

Institute, INSERM U846, Univ. de Lyon, Univ. Lyon I, Inst. of 

Neuroinformatics, Swiss Federal Inst. of Technol. (University 

ETH). 

4:00 A8 435.8 Alteration of gene expression profiles in 

the fetal cerebrum after injection of leukemia inhibitory factor 

into dams. T. HATTA*; H. SHIMADA; E. SIMAMURA; Y. 

ISHIGAKI; N. HIGASHI; T. TATSUNO; F. TAKANO. Kanazawa 

Med. Univ., Kanazawa Univ. 

1:00 A9 435.9 Proliferation, migration and differentiation 

of new born cells in the adult brain of a cichlid fish. M. 

TELES*; G. K. H. ZUPANC; R. F. OLIVEIRA. Inst. Superior de 

Psicologia Aplicada, Inst. Gulbenkian de Ciência, Jacobs Univ. 

2:00 A10 435.10 IGFBP-3 inhibits the proliferation of neural 

progenitor cells. H. S. KALLURI*; R. J. DEMPSEY. Univ. 

Wisconsin. 

3:00 B1 435.11 Reversal of lactation-induced reduction of 

hippocampal neurogenesis by chronic stress. K. HILLERER; 

K. WÜNSCHE; M. KANDASAMY; I. D. NEUMANN; L. 

AIGNER; D. A. SLATTERY*. Univ. Regensburg, PMU 

Salzburg. 

4:00 B2 435.12 Characterization of the novel MRT-10 

family of Smoothened antagonists on brain progenitors. H. 

ROUDAUT; F. MANETTI; H. FAURE; T. GOROJANKINA; E. 

TRAIFFORT; A. SCHOENFELDER; A. MANN; A. SOLINAS; 

M. TADDEI; M. RUAT*. CNRS, Univ. of Siena, CNRS UMR 

7200. 

1:00 B3 435.13 Dendritically synthesized brain-derived 

neurotrophic factor (BDNF) promotes adult hippocampal 

neurogenesis by facilitating inhibitory transmission. E. G. 

WATERHOUSE*; B. XU. Georgetown Univ. 

2:00 B4 435.14 Hormonal modulation of neurogenesis in 

the hippocampus of the testicular feminized male (Tfm) rat in 

early postnatal development. J. WADDELL*; J. M. BOWERS; 

N. S. EDWARDS; M. M. MCCARTHY. Univ. of Maryland, 

Baltimore. 

3:00 B5 435.15 Newborn neurons contribute to the 

restoration of vagal viscerosensory innervation following 

capsaicin-induced neuronal damage in the adult rat. V. RYU*; 

Z. R. GALLAHER; K. CZAJA. Washington State Univ. 

4:00 B6 435.16 Rapid effects of glucocorticoid receptor 

activation on gap junction regulation and cell proliferation in 

neural progenitor cells. R. A. SAMARASINGHE*; M. LEWIS; 

D. B. DEFRANCO. Univ. of Pittsburgh. 

1:00 B7 435.17 Ethanol inhibition of neurogenesis through 

induction of IL-1beta and inflammasome proteins. J. Y. ZOU*; 

F. T. CREWS. Univ. North Carolina, Chapel Hill. 

2:00 B8 435.18 Impaired recruitment of seizure-generated 

neurons into functional memory networks following long-term 

amygdala kindling. E. Y. STERNER*; N. M. FOURNIER; J. 

J. BOTTERILL; W. N. MARKS; A. J. GUSKJOLEN; L. E. 

KALYNCHUK. Univ. of Saskatchewan, Yale Univ. 



3:00 B9 435.19 Methylmercury exposure decreases cell 

proliferation in the zebrafish (Danio rerio) embryonic neural 

tube. E. A. MOUSSA; S. A. HASSAN; L. C. ABBOTT*. Suez 

Canal Univ., Texas A&M Univ. 

4:00 B10 435.20 Survival of newborn cells in the rostral 

migratory stream and olfactory bulb following restricted supply 

of dopamine to the subventricular zone. Y. SUI; M. K. HORNE; 

D. STANIC*. Howard Florey Inst., Univ. of Melbourne. 

1:00 B11 435.21 Potent effects of resveratrol on the neural 

progenitor cells and hippocampal neurogenesis. H. PARK*; 

E. GONG; M. KIM; Y. JANG; S. OH; S. CHOI; J. LEE. Pusan 

Natl. Univ. 

2:00 B12 435.22 Spatiotemporal post-transcriptional 

regulation of Cyclin D2 mRNA induces an asymmetrical 

cell fate in neuroepithelial cells and self-organization of 

corticogenesis. Y. TSUNEKAWA*; M. TAKAHASHI; N. OSUMI. 

Tohoku Univ. Sch. of Medicine/Division of Developmental 

Neurosci. Cent. 

POSTER 

436. Cell Migration II 



1:00 B13 436.1 Involvement of leak potassium channels 

in migration of cortical neurons. Y. BANDO*; T. HIRANO; Y. 

TAGAWA. Dept. of Biophysics, Grad. Sch. of Science, Kyoto 

Univ. 

2:00 B14 436.2 Nav2 hypomorphic mutant mice are 

ataxic and exhibit abnormalities in cerebellar development. 

M. CLAGETT-DAME*; E. M. MCNEILL; M. KLOCKNER- 

BORMANN; E. ROESLER; L. E. TALTON; D. MOECHARS. 

Univ. of Wisconsin-Madison, Univ. of California, Johnson & 

Johnson. 

3:00 B15 436.3 Involvement of ARX (Aristaless related 

homeobox gene) in the normal and pathological development 

of cerebral cortex. S. BEGUIN*; H. BECQ-CLOT FAYBESSE; 

B. PELOSI; M. PASQUALETTI; C. CARDOSO; A. REPRESA. 

INMED-INSERM U901, Mediterranean Univ., Unit of cell 

biology and development. 

4:00 B16 436.4 Guiding neurons: Finding signals involved 

with interneuron migration during neocortical development. 

M. J. DAVIS*; S. POLUCH; G. MUELLER; S. L. JULIANO. 

Uniformed Services, Univ. Hlth. Sci. 

1:00 B17 436.5 Prenatal ethanol exposure: Effects on 

postmitotic neuronal migration in the fetal cerebral cortex. 

M. P. ARONNE; T. GUADAGNOLI; S. G. EVRARD; H. A. 

BRUSCO*. IBCN (UBA-CONICET). 

2:00 B18 436.6 Cdk5 regulation of oligodendrocyte 

precursor cell migration. Y. MIYAMOTO*; T. TORII; A. 

TANOUE; J. YAMAUCHI. Natl. Inst. Child Hlth. Dev, Tokyo 

Inst. of Technol., The Japan Hlth. Sci. Fndn. 

3:00 B19 436.7 A new mouse model of ‘double-cortex’ - 

The role of RhoA in cortical development. S. CAPPELLO*; C. 

BÖHRINGER; C. BRAKEBUSCH; M. GÖTZ. Inst. of Stem 

Cell Research, Helmholtz Ctr. Munich, Biomed. Institute, 

BRIC, Univ. of Copenhagen, Inst. of Physiology, Univ. of 

Munich. 

4:00 B20 436.8 Cerebellar granule cells exhibit two distinct 

rhythms (short-term and circadian rhythms) of migration in 

vivo. H. KOMURO*; Y. LI; Y. KOMURO. Lerner Res. Inst. 

Cleveland Clin. Fndtn. 


Mon. PM

1:00 B21 436.9 α2-chimaerin regulates laminar positioning 

in the cerebral cortex. J. IP; L. SHI; Y. ITOH; W. FU; Y. 

GOTOH; A. FU; N. Y. IP*. The Hong Kong Univ. of Sci. & 

Technol., The Univ. of Tokyo. 

2:00 B22 436.10 Somatic mtDNA mutations during 

brain development can lead to stochastic migration 

disturbances. J. M. ROSS*; M. TERZIOGLU; K. PERNOLD; 

K. LUNDSTRÖMER; S. BRENÉ; A. TRIFUNOVIC; N. 

LARSSON; B. J. HOFFER; L. OLSON. NIH, Karolinska 

Institutet, Max Planck Inst. for Biol. of Ageing, Univ. of 

Cologne. 

3:00 B23 436.11 p27Kip1 promotes tangential migration 

of cortical interneurons by regulating nucleokinesis and 

branching. L. NGUYEN*; N. THOMAS; S. LAGUESSE; L. 

MALINOUSKAYA; P. CLOSE; O. MALAISE; A. PURNELLE; 

O. RAINETEAU; K. CAMPBELL; M. FERO; B. MALGRANGE; 

C. METIN; A. CHARIOT; A. BESSON; G. MOONEN. Univ. of 

Liège / GIGA-Neurosciences, Univ. of Liège / GIGA-Signal 

Transduction, Univ. of Zürich/ETH, Children’s Hosp. Res. 

Fndn., Fred Hutchinson Cancer Res. Ctr., Univ. Paris 6, Univ. 

Paul Sabatier. 

4:00 B24 436.12 A novel role for neuritin (cpg15): 

The regulation of neuronal migration. M. GALBIATI*; G. 

CAPPELLETTI; D. CARTELLI; A. CARIBONI; A. ZITO; A. 

POLETTI. Univ. of Milan. 

1:00 B25 436.13 • Long-term neural progenitor migration 

after cortical ischemia. A. OSMAN; H. KUHN*. Univ. 

Gothenburg, Univ. of Khartoum. 

2:00 B26 436.14 Astrocyte-secreted factors modulate PSA 

expression and migration of dentate granule cells. M. SAJO*; 

N. MATSUKI; R. KOYAMA. the university of tokyo. 

3:00 B27 436.15 New evidence that the heterotrimeric G 

protein Goα may directly interact with an Amyloid Precursor 

Protein ortholog (APPL) in migrating neurons. J. M. 

RAMAKER*; T. L. SWANSON; P. F. COPENHAVER. Oregon 

Hlth. & Sci. Univ. 

4:00 B28 436.16 The effects of neurotrophins on schwann 

cell migration. M. DE BELLARD*; J. M. WALKER; M. B. 

CORNEJO; M. SOMMERVILLE; D. NAMBI. Calif State Univ, 

Northridge, California State University, Northridge. 

1:00 C1 436.17 Migratory behavior and placement of 

cortical interneurons in a mouse model of DiGeorge/22q11 

deletion syndrome. D. W. MEECHAN; E. S. TUCKER; T. M. 

MAYNARD; A. LA MANTIA*. The George Washington Univ. 

Sch. of Med., West Virginia Univ. Sch. of Med., UNC Chapel 

Hill. 

POSTER 

437. Neuronal Differentiation II 



1:00 C2 437.1 Nitric oxide signaling pathway and RGS4 

are transcriptionally co-regulated during testosterone-induced 

neuronal addition to adult canary HVC. Z. CHEN*; F. J. SIM; 

C. LILLIEHOOK; R. YE; C. DELOUGHERY; S. NATESAN; 

R. PINAUD; S. A. GOLDMAN. Univ. Rochester, Xijing Hosp., 

Sanofi_Aventis. 


2:00 C3 437.2 Wnt-mediated regulation of Prox1 is 

critical for adult hippocampal neurogenesis. O. KARALAY*; 

K. DOBERAUER; M. KNOBLOCH; K. C. VADODARIA; 

L. BERTI; A. MIQUELAJAUREGUI; R. JAGASIA; M. M. 

TAKETO; V. TARABYKIN; D. C. LIE; S. JESSBERGER. 

Inst. of Cell Biology, Swiss Federal Inst. of Technol. (ETH), 

HelmholtzZentrum München, German Res. Ctr. for Envrn. 

Hlth., Max Planck Inst. for Exptl. Med., Inst. of Cell Biol. & 

Neurobiology, Neurocure Cluster of Excellence, Charité- 

Universitätsmedizin Berlin, Dept. of Pharmacology, Kyoto 

Univ. 

3:00 C4 437.3 Maintenance of phenotype in adult 

neurons. K. T. EADE*; D. W. ALLAN. Univ. of British Columbia. 

4:00 C5 437.4 Hippocampal neurogenesis affected by 

dysfunctional mastication and stress. H. AOKI*; K. KIMOTO; 

N. HORI; A. OHNO; M. KAWAHATA; T. YAMAMOTO; M. 

ONOZUKA. Kanagawa Dent. Col. 

1:00 C6 437.5 Genetic fate-mapping of adult-generated 

hippocampal dentate granule cells in the epileptic mouse 

brain. M. S. HESTER; B. L. MURPHY; H. YIN; S. C. 

DANZER*. Univ. of Cincinnati, Cincinnati Children’s Hsptl 

Med. Cntr. 

2:00 C7 437.6 Morphometric analyses of neural cell 

differentiation in adult hippocampal progenitor cultures. J. 

L. FUCHS*; J. D. DAU; E. LIGHTFOOT; M. MONTICINO; 

J. HSIEH; H. D. SCHWARK. Univ. of North Texas, Univ. of 

Texas, Univ. of Texas Southwestern Med. Ctr. 

3:00 C8 437.7 Targeting novel integrative nuclear 

FGFR1 signaling (INFS) reconstitutes active neurogenesis in 

adult brain. S. T. NARLA*; J. M. ALETTA; M. BENCHERIF; 

M. STACHOWIAK; E. STACHOWIAK. Univ. of Buffalo, 

CH3Biosystems, Targacept Inc. 

4:00 C9 437.8 Single cell analysis of L1 retrotransposition 

during neurogenesis. M. J. MCCONNELL*; A. MAHENDRAN; 

F. H. GAGE. Salk Inst. For Biol. Studies, Salk Inst. for Biol. 

Studies. 

1:00 C10 437.9 Analysis of the stage specific 

transcriptome in adult hippocampal neurogenesis. E. J. 

ENGLBERGER; M. COVIC; R. JAGASIA; K. MERZ; A. 

BENET-PAGES; T. STROM; A. BENDER; S. COUILLARD- 

DESPRES*; C. LIE. Helmholtz Zentrum München, Inst. of 

Developmental Genet., Roche, Helmholtz Zentrum München, 

Inst. of Human Genet., LMU München, Dept. of Neurol., 

Paracelsus Med. Univ. - Inst. For Mol. Regenerative Med. 

2:00 C11 437.10 Cell-autonomous role of small Rho 

gtpases Rac1 and Cdc42 in adult neurogenesis. K. 

VADODARIA*; R. BAUMANN; U. SUTER; C. BRAKEBUSCH; 

S. JESSBERGER. Inst. of Cell Biology, Swiss Federal Inst. of 

Technol. (ETH), Biomed. Institute, Univ. of Copenhagen. 

3:00 C12 437.11 Kinin-B2 receptors modulate neurogenesis 

and gliogenesis of neural stem cells. C. A. TRUJILLO*; T. T. 

SCHWINDT; C. LAMEU; H. ULRICH. Univ. de São Paulo, Ctr. 

for Applied Toxinology CAT/CEPID, Inst. Butantan. 

4:00 C13 437.12 Floor plate-specific expression of Nato3 is 

regulated by a novel evolutionarily-conserved Foxa2-binding 

promoter. N. BEN-ARIE*, IV; A. MANSOUR; E. NISSIM- 

ELIRAZ; S. ZISMAN; T. GOLAN-LEV; O. SCHATZ; A. KLAR. 

Hebrew Univ. Jerusalem. 

1:00 C14 437.13 Intrinsically regulated differences in the 

morphological and electrophysiological development of 

neurons from different brain regions. J. HUNG; T. CHOMIAK; 

M. NGUYEN; B. HU*. Univ. of Calgary. 



2:00 C15 437.14 The first neurons of the human cerebral 

cortex belong to a population of unusual, precocious cells 

also seen in the basal diencephalon and in placodal regions 

outside the brain. I. BYSTRON*; P. RAKIC; C. BLAKEMORE. 

Univ. of Oxford, Yale Univ. Med. Sch. 

3:00 C16 437.15 Cannabinoid type 1 receptor-mediated 

modulation of murine subventricular zone neurogenesis. 

S. XAPELLI*; R. A. DE MELO REIS; C. S. SCHITINE; L. 

CORTES; A. HEIMANN; E. S. FERRO; F. AGASSE; L. 

BERNARDINO; J. O. MALVA. Ctr. For Neurosci. and Cell 

Biol., Inst. de Biofísica Carlos Chagas Filho, Proteimax, 

Laboratório de Biologia Celular e do Desenvolvimento, Inst. 

de Ciências Biomédicas. 

4:00 C17 437.16 Comprehensive expression profiling of 

novel neurotrophic factors in the developing mouse brain. P. 

HORN*; J. R. JØRGENSEN; C. HANSEN; T. N. PETERSEN; 

S. BRUNAK; L. U. WAHLBERG; T. E. JOHANSEN. NsGene 

A/S, Wilhelm Johansens Ctr., Ctr. for Biol. Sequence Analysis. 

1:00 C18 437.17 Characterization of mechanisms involving 

in decrease of P2X 7 receptor expression in retinoic aciddifferentiated 

N2a cells. W. SHIH; Y. LIN; P. WU; J. YU; S. H. 

SUN*. Inst. of Neuroscience, Natl. Yang Ming Univ., Dept. of 

Life Science, Natl. Yang Ming Univ. 

2:00 C19 437.18 Effects of paraoxon during cellular 

differentiation of neuronal progenitor cells. A. H. MARTINS*; 

V. ORTIZ-BERRIOS; N. M. BOUKLI; T. T. SCHWINDT; C. A. 

TRUJILLO; P. D. NEGRAES; H. ULRICH; P. A. FERCHMIN; 

V. A. ETEROVIC. Univ. Central Del Caribe, Univ. Central del 

Caribe, Univ. of Sao Paulo. 

3:00 C20 437.19 P2X purinergic receptors expression 

is altered by directed differentiation of neural progenitors 

into neurons. P. D. NEGRAES*; T. T. SCHWINDT; C. A. 

TRUJILLO; C. LAMEU; H. ULRICH. Univ. de São Paulo, Ctr. 

for Applied Toxinology - CAT/CEPID, Inst. Butantan. 

4:00 C21 437.20 Neogenin regulation of mouse subgranular 

zone neurogenesis. D. LEE*; X. ZHU; L. MEI; W. XIONG. 


1:00 C22 437.21 • Endooligopeptidase activity of Ndel1 

(nuclear-distribution gene E homolog like-1) is critical for 

neurite outgrowth. M. A. HAYASHI*; J. R. GUERREIRO; E. 

CHARYCH; A. KAMIYA; R. L. BARBOSA; M. F. MACHADO; 

V. OLIVEIRA; A. SAWA; A. C. M. CAMARGO; N. J. 

BRANDON. Unifesp, Inst. Butantan, Pfizer Global R&D, Johns 

Hopkins Univ. Sch. of Med. 

2:00 C23 437.22 Assessment of differentiated and surviving 

cells in the hippocampal dentate gyrus of CAV2.1 calcium 

ion channel mutant mice. F. NIGUSSIE*; P. HUANG; L. C. 

ABBOTT. Texas A&M Univ. 

3:00 C24 437.23 Influence of the delta opioid receptors 

in differentiation and protection of dopaminergic neurons. F. 

MACHO; P. LAW; R. E. RODRIGUEZ*. Inst. of Neurosci., 

Univ. of Minnesota, Inst. of Neuroscienc. 

4:00 C25 437.24 Fgf signaling controls surface area 

expansion of the embryonic cerebral cortex. B. G. RASH*; F. 

M. VACCARINO. Yale Univ. 

1:00 C26 437.25 The role of Hmx1 in trigeminal ganglion 

development. L. A. QUINA*; Y. A. HSU; T. COX; C. BAKER; 

E. E. TURNER. Seattle Children’s Res. Inst., Univ. of 

Washington, Univ. of Cambridge. 

2:00 C27 437.26 Protein phosphatase 2A methylation 

plays a critical role in neurite outgrowth. J. SONTAG; V. 

NUNBHAKDI-CRAIG; E. SONTAG*. Univ. of Newcastle, UT 




3:00 C28 437.27 • Essential function of Sbno1 in mouse 

neurogenesis. A. TAKANO*; H. IMAI; T. TERASHIMA; Y. 

KATSUYAMA. Kobe uciversity. 

4:00 C29 437.28 miRNA-132 regulates the differentiation 

and synaptic integration of postnatally generated neurons 

from the SVZ. M. S. PATHANIA*; L. YAN; V. GORDON; J. 

PLATEL; A. WILLIAMSON; Z. TENG; X. ZHAO; A. BORDEY. 

Yale Univ. Sch. of Med., Univ. of Saarland Sch. of Med., Univ. 

of New Mexico Sch. of Med. 

1:00 C30 437.29 Identification of a neuronal signature that 

defines mature neurons. H. FELFLY; A. MUOTRI; J. XUE; D. 

ZHOU*; G. G. HADDAD. Sch. of Med, UCSD. 

POSTER 

438. Glial Differentiation 



1:00 C31 438.1 Hyaluronidase activity prevents 

remyelination and inhibits oligodendrocyte progenitor 

differentiation. M. A. PRESTON*; F. BANINE; W. SU; R. 

XING; J. STRUVE; S. FOSTER; C. WINKLER; S. BACK; L. 

SHERMAN. OHSU/ONPRC. 

2:00 C32 438.2 A thyroid hormone beta receptor selective 

ligand, GC-1, enhances oligodendrogenesis. E. G. POTTER*; 

A. N. BARANOWSKI; J. CARMEN; J. D. ROTHSTEIN; P. A. 

CALABRESI. Johns Hopkins Univ. 

3:00 C33 438.3 Both direct and indirect effect of 

thyroid hormone in oligodendrocyte lineage. F. PICOU*; 

T. FAUQUIER; F. CHATONNET; F. FLAMANT. Inst. De 

Génomique Fonctionnelle De Lyon Umr5242 CNRS/INRA/ 

UCBL/ENSL. 

4:00 C34 438.4 NG2+ progenitor response and 

differentiation potential in white matter stroke. E. G. 

SOZMEN*; D. K. CRAWFORD; S. TIWARI-WOODRUFF; S. 

T. CARMICHAEL. Geffen Sch. of Med. at UCLA. 

1:00 C35 438.5 Characterization of plp-GFP mice 

to visualize the myelin status upon focal demyelination. 

J. FERENT; M. LEFEBVRE-ROQUE; M. RUAT; E. 

TRAIFFORT*. CNRS (UPR 3294). 

2:00 C36 438.6 Uncoupling between proliferation and dedifferentiation 

in adult Schwann cells: Role of cAMP and JNK 

in the maintenance of the differentiated state. J. SOTO*; K. 

BACALLAO; P. MONJE. Univ. of Miami. 

3:00 C37 438.7 Small molecule screen to identify 

compounds that promote astrogliogenesis from glial 

progenitor cells. J. S. CARMEN*; Y. LI; E. POTTER; P. 

CALABRESI; J. ROTHSTEIN. Johns Hopkins SOM. 

4:00 C38 438.8 Meningeal cells express astrocyteinducing 

cytokines in the developing mouse brain. T. 

SANOSAKA*; M. NAMIHIRA; T. TAKIZAWA; K. NAKASHIMA. 

Nara Inst. of Sci. and Technol. 

1:00 D1 438.9 β1 integrins regulate the ability of 

oligodendrocytes to myelinate axons in the cerebral cortex. 

T. NGUYEN*; C. BARROS; U. MULLER; H. COLOGNATO. 

SUNY Stony Brook, The Scripps Res. Inst. 

2:00 D2 438.10 KLF9 is required for the normal timing of 

T3-promoted oligodendrocyte differentiation and myelination. 

J. C. DUGAS*; A. IBRAHIM; B. A. BARRES. Stanford Univ. 


Mon. PM

3:00 D3 438.11 A developmental profile of microglial 

morphology in males and females across multiple brain 

regions. P. W. SHOLAR*; J. M. SCHWARZ; S. D. BILBO. 

Duke Univ. 

4:00 D4 438.12 Changes in white matter astrocyte function 

and gliogenesis in a mouse model of hypoxia-induced 

premature brain injury. M. RAYMOND*; V. GALLO. Children’s 

Natl. Med. Ctr., The George Washington Univ. 

1:00 D5 438.13 A role for a BRG1-NFkB complex during 

peripheral nerve myelination. A. S. LIMPERT*; Y. CHEN; Q. R. 

LU; B. D. CARTER. Vanderbilt Univ. Med. Ctr., Univ. of Texas 


2:00 D6 438.14 Loss of uPAR in mice increases the 

number of postnatal cells in the somatosensory cortex. M. 

SHAHROKH; M. H. BAE; E. M. POWELL*. Univ. Maryland, 

Baltimore. 

3:00 D7 438.15 Overexpression of EGFR in 

oligodendrocytes prevents sensori-motor deficits in a 

murine model of premature brain injury. J. SCAFIDI*; B. 

JABLONSKA; A. AGUIRRE; V. GALLO. Children’s Natl. Med. 

Ctr., Stony Brook Univ. 

4:00 D8 438.16 Effects of neurotrophin 3 and brain derived 

neurotrophic factor on myelination in the mouse cerebrum 

in the lactation period. R. HASHIMOTO*; A. MATSUMOTO; 

A. ONO; S. NISHIMOTO; J. UDAGAWA; H. OTANI. Dept. of 

Developmental Biology, Fac. of Medicine, Shumane Univ. 

1:00 D9 438.17 p38α signaling in oligodendrocyte 

development and myelination. V. SELVARAJ*; M. HORIUCHI; 

C. A. GUADAGNA; N. S. PHUONG; T. ITOH; K. OTSU; W. 

DENG. Univ. of California, Shriners Hosp. for Children, Osaka 

Univ. 

2:00 D10 438.18 Planar cell polarity in ependymal 

ciliogenesis. F. TISSIR*; Y. QU; A. GOFFINET. Univ. 

Catholique De Louvain. 

3:00 D11 438.19 • Analysis of novel mTOR targets during 

oligodendrocyte differentiation. S. E. CIFELLI*; W. A. TYLER; 

M. R. JAIN; H. LI; T. L. WOOD. Univ. of Med. and Dent. of NJ. 

4:00 D12 438.20 TGF-beta1 promotes regionally radial 

glia-astrocyte transformation in cerebral cortex in vivo. J. S. 

SILVA*; D. F. FRANCO; C. A. MORAES; E. S. ANTON; F. C. 

A. GOMES. Univ. Federal Do Rio De Janeiro, Univ. Federal 

do Rio de Janeiro, Univ. of North Carolina at Chapel Hill. 

1:00 D13 438.21 Expression of glycoprotein non-metastatic 

melanoma B in the rat central nervous system. J. HUANG; W. 

MA; H. HIGASHIDA; S. YOKOYAMA*. Kanazawa Univ. Grad. 

Sch. of Med. 

2:00 D14 438.22 Overexpression of the Fucosyltransferases 

4 and 9 leads to activation of STAT 1 and STAT 2 in primary 

astrocytes. B. SCHWARZ-HERZKE*; A. KREMER; J. K. MAI. 

Heinrich-heine-Universität Düsseldorf, Erasmus Med. Ctr., 

Inst. of Anat. 

3:00 D15 438.23 Quantifying neural cell birth in the neonatal 

mouse spinal cord. Y. QU*; D. BECKER; J. W. MCDONALD. 

Kennedy Krieger Inst. 

4:00 D16 438.24 The ’double settlement’ of the perivascular 

glia - Changes during the radial glia/astrocytes replacement. 

An immunohistochemical study in rats. K. MIHALY*; I. 

ADORJAN; K. POCSAI; Z. BAGYURA. Semmelweis Univ. 

Med., Vascular and Heart Surgery. 


1:00 D17 438.25 Neurofibromatosis-1 regulates neural stem 

cell proliferation and glial differentiation in a region-specific 

manner. D. LEE*; T. YEH; R. J. EMNETT; C. R. WHITE; D. H. 

GUTMANN. Washington Univ. Sch. Med., Chang Gung Mem. 

Hosp. and Univ. 

2:00 D18 438.26 Enlarged lateral ventricles, aberrant 

behavior and retinal defects resulting from over-expression of 

PDGF in neural stem and progenitor cells. T. BERGSTRÖM; 

M. NIKLASSON; P. EDQVIST; X. ZHANG; F. HALLBÖÖK; 

M. FORSBERG; K. FORSBERG-NILSSON*. Uppsala Univ., 

Karolinska Institutet. 

POSTER 

439. Synaptic Adhesion Molecules 



1:00 D19 439.1 NMDA receptor activity regulates SAP102 

mobility in spines. C. ZHENG*; R. S. PETRALIA; Y. WANG; B. 

KACHAR; R. J. WENTHOLD. NIDCD/NIH. 

2:00 D20 439.2 Activity-dependent excitatory synapse 

validation by two neurexin-ligands, neuroligins and LRRTMs. 

J. KO*; M. V. FUCCILLO; G. J. SOLER-LLAVINA; R. C. 

MALENKA; T. C. SUDHOF. Stanford Univ., Howard Hughes 

Med. Inst. 

3:00 D21 439.3 Modulation of synaptic adhesion by 

specific N-glycosylation at the SynCAM immunoglobulin 

interface. T. BIEDERER*; A. I. FOGEL; Y. LI; Q. WANG; J. 

GIZA; T. T. LAM; Y. MODIS. Yale Univ., Natl. Inst. of Neurolog. 

Disorders and Stroke, Columbia Univ. 

4:00 D22 439.4 Muscle β-catenin regulates motor nerve 

terminal formation and function. H. WU*; A. BARIK; W. 

XIONG; L. MEI. Med. Col. of Georgia. 

1:00 D23 439.5 Elucidating the role of protein 

palmitoylation in the regulation of synaptic adhesion 

molecules. S. BRIGIDI*; A. SHAN; S. X. BAMJI. Univ. of 


2:00 D24 439.6 Trans-synaptic interaction of glutamate 

receptor δ2 and neurexin through Cbln1 mediates cerebellar 

synapse formation. T. UEMURA*; S. LEE; M. YASUMURA; 

T. TAKEUCHI; T. YOSHIDA; M. RA; R. TAGUCHI; K. 

SAKIMURA; M. MISHINA. Grad. Sch. of Med., Univ. of Tokyo, 

Brain Res. Inst., Niigata Univ. 

3:00 D25 439.7 Calcium channels link synapse organizer 

laminin β2 with active zone proteins to organize motor nerve 

terminals. J. CHEN*; H. NISHIMUNE. Univ. of Kansas Med. 

Ctr. 

4:00 D26 439.8 Distinct roles of protocadherin gamma 

isoforms: Type C genes are essential for survival of spinal 

interneurons and development of specific synapses on 

motoneurons. W. V. CHEN; F. J. ALVAREZ*; E. J. GEIMAN; T. 

MANIATIS. Columbia Univ., Wright State Univ. 

1:00 D27 439.9 Selected SALM (synaptic adhesion-like 

molecule) family proteins regulate synapse formation. W. 

MAH*; J. KO; J. NAM; W. CHUNG; E. KIM. Korea Advanced 

Inst. of Sci. and Technol. (KAIST), Neurosci. Inst. 

2:00 D28 439.10 LRRTM2 interacts with Neurexin1 and 

regulates excitatory synapse formation. J. DE WIT*; E. 

SYLWESTRAK; M. L. O’SULLIVAN; S. OTTO; K. TIGLIO; J. 

N. SAVAS; J. R. YATES, III; D. COMOLETTI; P. TAYLOR; A. 

GHOSH. Univ. California SD, The Scripps Res. Inst. 



3:00 D29 439.11 Neural cell adhesion molecule 

(NCAM)-mediated Fyn activation promotes GABAergic 

synapse maturation in adolescent mouse cortex. B. 

CHATTOPADHYAYA; E. BAHO; M. SCHACHNER; G. DI 

CRISTO*. CHU Ste. Justine-Université De Montréal, Zentrum 

für Molekulare Neurobiologie, Univ. Hamburg, CHU Ste. 

Justine-Université De Montréal. 

4:00 D30 439.12 SynCAM 1 adhesion dynamically 

regulates synapse number and impacts plasticity and learning. 

E. M. ROBBINS*; A. J. KRUPP; A. K. GHOSH; A. I. FOGEL; 

A. A. BOUCARD; T. C. SÜDHOF; V. STEIN; T. BIEDERER. 

Yale Univ., Max Planck Inst. of Neurobio., Cornell Univ., 

NINDS, Stanford Univ. 

1:00 D31 439.13 β-catenin stabilization regulates the 

form and function of hippocampal synapses. F. MILLS*; 

T. BARTLETT; Y. T. WANG; S. X. BAMJI. Univ. of British 

Columbia. 

2:00 D32 439.14 Extracellular tyrosine residues regulate 

EphB2 surface localization and degradation. S. I. SHEFFLER- 

COLLINS*; G. ZHANG; T. A. NEUBERT; M. B. DALVA. Univ. 

of Pennsylvania, New York Univ. Sch. of Med. 

3:00 D33 439.15 Characterization of the SynDIG1-related 

transmembrane protein SynDIG3 in AMPA receptor synapse 

development. J. H. HSIANG*; J. YU; I. KAUR; E. DIAZ. Univ. 

of California, Davis. 

4:00 D34 439.16 Specificity of intercellular interactions 

regulated by the combinatorial cell-surface expression of the 

clustered protocadherins. J. A. WEINER*; A. KEELER; M. 

OMAR; D. SCHREINER. The Univ. of Iowa. 

1:00 D35 439.17 Cadherin-9 regulates input-specific 

synapse formation in the developing hippocampus. M. E. 

WILLIAMS*; S. A. WILKE; E. DAVIS; A. DAGGETT; B. 

RIPLEY; G. KLEIN; A. GHOSH. UCSD, Univ. Med. Clin. 

2:00 D36 439.18 Intracellular binding motifs mediate 

SALM1 trafficking in hippocampal neurons. G. K. SEABOLD*; 

P. Y. WANG; R. S. PETRALIA; K. CHANG; A. ZHOU; Y. 

WANG; R. J. WENTHOLD. NIDCD/NIH. 

3:00 D37 439.19 Investigating the roles of neuronalcadherin 

and nectins in synapse formation using in 

vivo approaches. W. BELKAID; O. DE FARIA, Jr; A. 

DHAUNCHAK; D. R. COLMAN*. Montreal Neurolog. Inst., 

Montreal Neurol Inst. 

4:00 D38 439.20 PGRN deficiency linked to FTD 

decreases neural connectivity but enhances the efficacy 

of individual synapses. E. PETOUKHOV*; L. TAPIA; A. 

GUO; E. YOSHIDA; F. MILLS; N. YANG; C. VASUTA; 

A. MILNERWOOD; I. MACKENZIE; L. RAYMOND; M. 

CYNADER; W. JIA; S. BAMJI. Univ. of British Columbia. 

1:00 D39 439.21 Generation and characterization of a 

β-catenin dopamine neuron specific conditional knock-out 

mice. O. DIAZ-RUIZ; Y. ZHANG; L. SHAN; S. SARABI; N. 

MALIK; A. F. HOFFMAN; E. FRANCOIS; C. M. BACKMAN*. 

NIDA/NIH. 

2:00 D40 439.22 Neuroligin overexpression drives synapse 

formation during adult hippocampal neurogenesis. E. 

SCHNELL*; A. L. BENSEN; E. WASHBURN; B. W. LUIKART; 

G. L. WESTBROOK. OHSU Vollum Inst., Portland VA Med. 

Ctr. 

3:00 D41 439.23 Characterization of SynDIG1 knockout 

mice with in vivo studies of excitatory synapse development 

and function. S. A. MCMAHON*; D. SPECA; E. DIAZ. Univ. of 

California Davis. 



4:00 D42 439.24 MHCI and MEF2 interact to regulate the 

initial establishment of cortical connections. B. ELMER*; 

S. FLAVELL; M. GREENBERG; K. MCALLISTER. Univ. 

California Davis, Harvard Med. Sch., Univ. of California. 

1:00 E1 439.25 Functional analysis of neuroligin 2 in the 

developing zebrafish spinal cord. J. FIERRO*, JR; C. DAVEY; 

A. TALLAFUSS; P. WASHBOURNE. Univ. of Oregon. 

POSTER 

440. Development: Activity-Dependent Modulation of 

Connectivity I 



1:00 E2 440.1 Epibatidine disruption of retinal waves 

“freezes” overlap of retinogeniculate axons serving the two 

eyes during the initial period of eye-specific segregation, and 

causes desegregation of axons during the period of ON/OFF 

segregation. B. J. DERIEG; D. A. SLUTSKY; B. CHAPMAN*. 

Univ. California-Davis. 

2:00 E3 440.2 Chronic in vivo imaging of thalamocortical 

axon structure in mouse primary visual cortex. J. E. 

COLEMAN*; L. A. KHIBNIK; M. F. BEAR. HHMI/MIT. 

3:00 E4 440.3 CaMKIIα local translation in the adult 

mouse olfactory bulb. M. NEANT-FERY*; A. TREMBLEAU; I. 

CAILLÉ. UPMC- UMR7102. 

4:00 E5 440.4 Delayed maturation of the visual 

optomotor response by sensory deprivation. E. KANG; S. 

DURAND; M. FAGIOLINI; C. CHEN*. Children’s Hosp, 


1:00 E6 440.5 Neural plasticity has signatures of early 

adversity. D. SAMPATH*; S. CHATTARJI; B. M. KUTTY; T. R. 

LAXMI. NIMHANS (National Inst. of Mental Hlth. and Neuro 

Sci., NATIONAL CENTER FOR BIOLOGICAL SCIENCES. 

2:00 E7 440.6 Barrel formation in the somatosensory 

cortex by thalamocortical innervation. K. YUGE*; A. C. 

YOSHIDA; S. KIKUCHI; M. OGAWA; T. SHIMOGORI. RIKEN 

BSI. 

3:00 E8 440.7 Relative contribution of feed-forward and 

inhibitory connections to expression of ocular dominance 

plasticity in layer 4 of visual cortex. L. A. KHIBNIK*; K. K. A. 

CHO; M. F. BEAR. MIT. 

4:00 E9 440.8 Ca 2+ -spike-driven specification of 

neurotransmitters in embryonic development is non-cellautonomous. 

L. XU*; N. C. SPITZER. UCSD, Kavli Inst. for 

Brain and Mind. 

1:00 E10 440.9 Changing propagation patterns and 

transmitter participation of spontaneous waves of activity 

in the developing mouse neocortex. C. R. EASTON*; J. 

CONHAIM; M. I. BECKER; L. F. MATHER; J. G. MOORE; R. 

F. HEVNER; W. J. MOODY. Univ. of Washington. 

2:00 E11 440.10 Olfactory circuit activation induces 

neurotransmitter respecification affecting behavior. D. 

DULCIS*; S. ENRIGHT; M. L. LAU; N. C. SPITZER. UCSD, 

Kavli Inst. for Brain and Mind. 


Mon. PM

3:00 E12 440.11 Development of myelinated axon length 

density and myelin-associated glycoprotein expression in 

the neocortex of chimpanzees compared to humans. D. J. 

MILLER*; T. DUKA; C. D. STIMPSON; S. J. SCHAPIRO; W. 

B. BAZE; M. J. MCARTHUR; A. J. FOBBS; D. E. WILDMAN; 

J. M. ERWIN; P. R. HOF; C. C. SHERWOOD. George 

Washington Univ., The Univ. of Texas M.D. Anderson Cancer 

Ctr., Walter Reed Army Med. Ctr., Ctr. for Mol. Med. and 

Genet., Mount Sinai Sch. of Med. 

4:00 E13 440.12 A competition-based mechanism mediates 

developmental refinement of tectal neuron receptive fields. W. 

DONG*; C. D. AIZENMAN. Brown Univ. 

1:00 E14 440.13 Coordinated network plasticity in Xenopus 

optic tectum. K. PODGORSKI*; K. HAAS. Univ. of British 

Columbia. 

2:00 E15 440.14 Acute modulation of embryonic mouse 

hindbrain spontaneous activity by SSRI application. H. 

WATARI*; K. MUIR; M. M. BOSMA. Univ. of Washington. 

3:00 E16 440.15 � Disruption of mouse 5HT neuron 

development by maternal SSRI administration. M. R. SHI; B. 

SNIDER; M. M. BOSMA*. Univ. Washington. 

4:00 E17 440.16 � GABAergic activity during a sensitive 

window of embryonic development is critical for development 

of coordinated swimming behavior. A. H. BANACH*; K. L. 

TODD; J. A. MURPHY; K. A. FRENCH; W. B. KRISTAN, Jr. 

Univ. of California San Diego. 

1:00 E18 440.17 Effects of chlorpyrifos exposure on 

the development of the cholinergic nervous system of the 

zebrafish and C. elegans. F. RADONIQI; G. ORONA; O. MAC; 

S. HAN; D. BOURGAIZE; E. A. FRADINGER*. Whittier Col. 

2:00 E19 440.18 � Differences in the spontaneous neuronal 

activity in PMBSF in rats enucleated at birth. D. PEREZ- 

TORRES; G. GUTIERREZ-OSPINA; J. GUTIERREZ-RUIZ; 

M. VELAZQUEZ-PANIAGUA; B. PRIETO-GOMEZ*. Univ. 

Nacional Autonoma Mexico. 

3:00 E20 440.19 Activity-dependent transcriptional 

regulation of the TARP gamma-4 in developing cortical 

networks. L. YANG; S. GURWARA; A. CHUNG; B. J. HALL*. 

Tulane Univ. 

4:00 E21 440.20 Regulation of cortical synapse maturation 

and homeostatic synaptic plasticity by NR2B-containing 

NMDA receptors. C. WANG*; J. L. HOHENSTEIN; B. 

NAKASHIMA; B. J. HALL. Tulane Univ. 

1:00 E22 440.21 NMDA and mGLUR5 receptor activation is 

required for the developmental and activity-dependent switch 

in the NR2 subunit composition. J. A. MATTA*; J. T. ISAAC. 

NIH. 

2:00 E23 440.22 Sensitivity of adolescent and adult male 

rats to the dysphoric effects of the selective NMDA NR2B 

antagonist ifenprodil. R. L. RAMIREZ*; L. P. SPEAR. SUNY 

Binghamton. 

3:00 E24 440.23 Differential role for synchronous electrical 

activity in the maturation of hippocampal CA3 and CA1 

synaptic circuitries. J. HUUPPONEN*; S. MOLCHANOVA; S. 

LAURI; T. TAIRA. Univ. of Helsinki. 

4:00 E25 440.24 Kappa opioid receptor regulation of 

spontaneous calcium oscillations in embryonic spinal cord 

neurons. L. KELAMANGALATH*; S. DRAVID; J. ALDRICH; T. 

F. MURRAY. Creighton Univ., The Univ. of Kansas. 


1:00 E26 440.25 Repetitive activation of the corticospinal 

tract by means of rTMS may reduce the efficiency of 

corticomotoneuronal synapses. W. TAUBE*; C. LEUKEL; M. 

SCHUBERT; J. B. NIELSEN; J. LUNDBYE-JENSEN. Univ. of 

Freiburg, Univ. of Zurich, Univ. of Copenhagen. 

POSTER 

441. Evolution and Development 



1:00 E27 441.1 Transcriptional regulation of hypothalamic 

development in amphibians. J. L. MICHAUD*; K. 

BOUYAKDAN. Hôpital Sainte-Justine. 

2:00 E28 441.2 The role of the medial prefrontal cortex 

in emotion regulation of infants, juveniles, and adolescents. 

T. CHAN*; K. KYERE; J. MADRID; C. SCHUBMEHL; A. 

CHEMIAKINE; P. KABITZKE; C. WIEDENMAYER. New York 

State Psychiatric Inst., Columbia Univ. 

3:00 E29 441.3 Mg2+ effect on rat neural activity in vitro. 

K. TORIMITSU*; Y. FURUKAWA. NTT Basic Res. Labs. 

4:00 E30 441.4 � Vascular development and sex 

differences in the region of the paraventricular nucleus of the 

hypothalamus. M. J. SCHOW; J. G. KNOLL; K. A. FRAHM; Q. 

ZHANG; S. A. TOBET*. Colorado State Univ. 

1:00 E31 441.5 • � Neuronal birthdates of posterior 

thalamic compartments in embryonic chicks. D. A. 

SCHNEIDER; A. M. LYNN; D. H. NICHOLS; L. L. BRUCE*. 

Creighton Univ. Sch. Med. 

2:00 E32 441.6 Species differences in early patterning of 

the avian brain. L. D. MCGOWAN*; A. MARTIN; E. KUO; E. S. 

MONUKI; G. F. STRIEDTER. UC Irvine. 

3:00 E33 441.7 Within-litter variance in maternal and 

neonate behavior predicts adult sibling variance in anxietyrelated 

behavior and SERT mRNA expression in rats. S. 

A. CAVIGELLI; C. M. RAGAN; E. LOKEN; B. C. JONES*. 

Pennsylvania State Univ. 

4:00 E34 441.8 • Patterns of npy, vip and nse during the 

development of the ovary of chicken and hen. M. GONZALEZ- 

DEL-PLIEGO OLIVARES*; E. AGUIRRE-BENITEZ; A. 

VELÁZQUEZ-CARRANZA; D. MARTÍN; C. SOLANO- 

AGAMA; M. MENDOZA. Univ. Nacional Autonoma De 

Mexico, CINVESTAV. 

1:00 E35 441.9 Relatives across the ventricle border: 

Insight into songbird telencephalic organization revealed 

through molecular profiling of embryonic development. C. 

CHEN*; C. HITCHCOCK; E. D. JARVIS. Duke Univ. 

2:00 E36 441.10 Evolutionary diversity of hindbrain motor 

innervation compared with branchial, occipital and pectoral 

patterning in jawed vertebrates. E. H. GILLAND*; L. MA; A. 

BASS; R. BAKER. Howard Univ., NYU Langone Med. Ctr., 

Cornell Univ. 

3:00 E37 441.11 A conserved enhancer in Zfp503/ Nolz- 

1 locus direct the LacZ expression in developing caudal 

CNS. Y. LIU; T. HUANG; F. LIU; L. CHANG*. Grad. Inst. 

of Mol. Systems Biomedicine, China Med. Univ., Inst. of 

Neuroscience, Natl. Yang-Ming Univ. 

4:00 E38 441.12 Effects of 30% globally reduced maternal 

nutrition (RMN) on multi-drug resistance protein 1 (MDR 1) 

in the baboon fetal frontal cortex (FC) and paraventricular 

nucleus (PVN) at 0.9 gestation. J. CHOI; T. J. MCDONALD*; 

P. W. NATHANIELSZ; C. LI. UT Hlth. Sci. Ctr. 



1:00 E39 441.13 Telomere length dynamics in brain and 

blood of mice. F. PIBIRI*; K. GRENNAN; L. CHENG; L. 

ZENG; E. GERSHON; C. LIU. Univ. of Chicago. 

2:00 E40 441.14 Hedgehog-dependent regulation of the 

VDUP1 tumor suppressor in Drosophila brain and mammalian 

tumor cells. R. E. DEARBORN*, Jr.; K. WRIGHT; M. 

CAMUSO; J. M. VOIGT. Albany Col. of Pharm. & Hlth. Sci. 

3:00 E41 441.15 Determinants of the timing of weaning in 

humans and other mammals. E. PSOUNI*; M. GARWICZ. 

Dept. of Psychology, Lund Univ., Kristianstad Univ. 

4:00 E42 441.16 Cyclic alternating pattern in infants with 

hypothyroidims and apnea central. R. SANTANA MIRANDA*; 

E. ESQUEDA LEON; Y. ARANA LECHUGA; G. TERAN; 

O. SANCHEZ ESCANDON; C. CASTILLO MONTOYA; 

C. MURATA; A. JIMENEZ; A. ROSA; J. VELAZQUEZ 

MOCTEZUMA. Sleep Disorder Clin. Univ. Autònoma 

Metropolitana, Sleep disorder clinic. Univ. Autonoma 

Metropolitana, Natl. Inst. Pediatrics, ILaseeb-ISR-IST. 

1:00 E43 441.17 Ih and GIRK modulation of kainate 

receptors induces abnormal GABA neuronal firing rates in 

schizophrenia(SZ). B. GISABELLA*; V. Y. BOLSHAKOV; F. M. 

BENES. Mclean Hosp., Harvard Med. Sch. 

2:00 E44 441.18 Network structure contingent on initial 

axon outgrowth in the developing rodent cortex: Empirical 

measurement and models. D. J. CAHALANE; B. CLANCY; 

M. A. KINGSBURY; E. GRAF; O. SPORNS; B. L. FINLAY*. 

Cornell Univ., Univ. of Central Arkansas, Indiana Univ., 

Washington Univ. 

3:00 E45 441.19 Multiple contributions of the 

Na+K+ATPase to brain ventricle formation. J. CHANG*; L. 

LOWERY; H. SIVE. Whitehead Institute/Mit. 

4:00 E46 441.20 MicroRNA processing is altered by the 

cold-stress inducible RNA-binding motif 3 protein, RBM3. J. 

PILOTTE*; L. LIAO; P. W. VANDERKLISH. The Scripps Res. 

Inst. 

1:00 E47 441.21 piRNA-directed DNA methylation in 

advanced paternal age and offspring psychiatric disorders. D. 

LIN*; M. MILEKIC; J. EDWARDS; J. GINGRICH. Columbia 

Med. Center/New York State Psychiatric Inst., Washingtion 


2:00 E48 441.22 Transgenerational epigenetic regulation 

of growth is regulated by maternal diet. G. A. DUNN*; T. L. 

BALE. Univ. Pennsylvania. 

3:00 E49 441.23 Epigenetic changes induced by 

developmental exposure of guinea pigs to chlorpyrifos. 

E. F. R. PEREIRA; M. AKKERMAN; Y. ARACAVA; W. R. 

RANDALL*; E. X. ALBUQUERQUE. Univ. Maryland Sch. 

Med. 

4:00 E50 441.24 Activity of evolutionary distinct classes of 

microRNAs in neuronal development. S. A. MANAKOV*; A. J. 

ENRIGHT; S. G. N. GRANT. The Wellcome Trust Sanger Inst., 

EMBL-EBI. 



POSTER 

442. Acetylcholine 


Mechanisms 


1:00 E51 442.1 Acetylcholinesterase: A dispensable 

enzyme in the brain. V. FARAR; J. CENDELIN; A. 

HRABOVSKA; J. MYSLIVECEK; E. KREJCI*. université Paris 

Descartes, Fac. of Med., Fac. of Pharm. of Comenius Univ., 

Charles Univ., Cesem, UMR 8194 CNRS. 

2:00 E52 442.2 Timing- and activity-dependent cholinergic 

modulation of hippocampal synaptic plasticity. Z. GU*; J. L. 

YAKEL. NIEHS/NIH. 

3:00 F1 442.3 Nicotinic and muscarinic agonists and 

anti-acetylcholinesterase drugs enhance NMDA responses in 

hippocampal CA1 pyramidal cells in vivo. K. SUMIKAWA*; M. 

ISHIBASHI; Y. YAMAZAKI. Univ. California Irvine. 

4:00 F2 442.4 Projections from hypothalamic arousal/ 

sleep centers to cholinergic, mesopontine tegmental complex 

in the rat. H. S. LEE*; E. Y. HONG. Konkuk Univ. 

1:00 F3 442.5 Cholinergic modulation of recurrent 

cortical network activity. M. WOELFEL*; D. A. MCCORMICK. 


2:00 F4 442.6 Electrophysiological and morphological 

characterization of cholinergic neurons in the nucleus basalis 

of adult mice. T. HEDRICK*; J. WATERS. Northwestern Univ. 

3:00 F5 442.7 Synapse- and subtype-specific modulation 

of synaptic transmission by nicotinic acetylcholine receptors 

in the ventrobasal thalamus of juvenile mice. Y. NAGUMO*; 

Y. TAKEUCHI; K. IMOTO; M. MIYATA. Tokyo Women’s Med. 

Univ., Natl. Inst. for Physiological Sci. 

4:00 F6 442.8 Electrophysiological characterization 

of basal forebrain cholinergic neurons in transgenic mice 

expressing green fluorescent protein under the promoter 

of choline acetyltransferase. C. T. UNAL; T. KOOS; L. 

ZABORSZKY*. Rutgers Univ. 

1:00 F7 442.9 Diet-induced folate deficiency has a 

greater effect on choline and neurotransmitter metabolism 

in adult than in young Sprague Dawley rats in the brain and 

peripheral tissues. N. A. CRIVELLO*; J. K. BLUSZTAJN; J. 

JOSEPH; B. SHUKITT-HALE; D. SMITH; A. GURAV. Tufts 

Univ., Boston Univ. Sch. of Med. 

2:00 F8 442.10 Cell-type specific cholinergic modulation of 

the mouse visual cortex. N. CHEN; G. PEREA; M. SUR*. MIT. 

POSTER 

443. GABA Receptors: Physiology II 


Mechanisms 


1:00 F9 443.1 Repeated exposure to volatile anesthetic 

causes insertion of barbiturate insensitive GABAA receptors 

on brainstem and cortical neurons in rats. K. B. HENGEN*; N. 

R. NELSON; S. M. JOHNSON; M. BEHAN. UW, Madison. 

2:00 F10 443.2 Bile salts synchronize hypothalamic 

network activity by blocking GABAA receptors. O. A. 

SERGEEVA*; S. R. SCHUBRING. Heinrich-Heine-Univ. 


Mon. PM

3:00 F11 443.3 α4βδ GABA A receptor expression in the 

amygdala of pre-pubertal and pubertal brains of female 

rodents. C. J. AOKI*; N. SABALIAUSKAS; S. S. SMITH. New 

York Univ., Sackler Inst. for Biomed. Sciences, NYU Langone 

Med. Ctr., SUNY Downstate Med. Ctr. 

4:00 F12 443.4 Regulation of cell surface expression of 

α4β2δ GABA A receptors. A. KUVER*; Q. GONG; S. S. SMITH. 

SUNY Downstate Hlth. Sci. Ctr. 

1:00 F13 443.5 Estrous cycle-related changes in CNS 

plasticity: Role of GABA A receptors. N. SABALIAUSKAS*; 

J. MOLLA; C. AOKI; S. S. SMITH. New York Univ., SUNY 

Downstate Med. Ctr. 

2:00 F14 443.6 Pubertal deficits in long term potentiation: 

A comparison of wild-type and α4 knock-out mice. H. SHEN; 

N. SABALIAUSKAS; G. HOMANICS; A. STELZER; C. J. 

AOKI; S. S. SMITH*. SUNY Downstate Med. Ctr., New York 

Univ., Univ. of Pittsburgh. 

3:00 F15 443.7 GABA A receptor β3 subunits are essential 

in striatal MSN tonic current. M. J. JANSSEN*; S. VICINI. 

Georgetown Univ. Med. Ctr. 

4:00 F16 443.8 Properties of the M3-M4 intracellular 

loop of the GABA(A) receptor revealed through site-directed 

mutagenesis. K. K. O’TOOLE*; A. JENKINS. Emory Univ. 

1:00 F17 443.9 • GABA-A receptor sensitivity to 

contaminants which leach from plastics. J. L. KOZUSKA*; I. 

M. PAULSEN; E. V. DANG; D. WEHRHAHN; A. HOLT; S. M. 

J. DUNN. Univ. of Alberta, Eppendorf AG. 

2:00 F18 443.10 Binge ethanol exposure during 

adolescence produces long-lasting changes in hippocampal 

tonic inhibition. R. L. FLEMING*; W. A. WILSON; S. D. 

MOORE; H. S. SWARTZWELDER. VA Med. Ctr., Duke Univ. 

Med. Ctr. 

3:00 F19 443.11 Effects of ethylenediamine - A putative 

GABA-releasing agent - In rat hippocampal slices and 

neocortical activity in vivo. J. I. ADDAE*; T. W. STONE. Univ. 

of the West Indies, Univ. of Glasgow. 

4:00 F20 443.12 Metabotropic glutamate receptors regulate 

the GABA equilibrium potential in neonatal and juvenile rat 

hippocampal CA1 neurons. B. YANG; P. S. RAJPUT; U. 

KUMAR; B. SASTRY*. Dept. of Anesthesiology, Pharmacol. & 

Therapeut., UBC, Univ. British Columbia Fac Med. 

1:00 F21 443.13 Na-K-2Cl cotransporter 1 (NKCC1) 

knockdown in postnatal subventricular zone progenitors in 

vivo decreases cell production. S. YOUNG*; M. TAYLOR; O. 

HENSCHEL; A. BORDEY. Yale Univ., Yale Univ. Sch. of Med. 

2:00 F22 443.14 Intracellular chloride concentration 

influences the expression of α1 and α3 subunits of GABA A 

receptor. F. SUCCOL*; E. PETRINI; A. BARBERIS. Italian 

Inst. of Technol. 

3:00 F23 443.15 Implications of a novel regulatory 

mechanism for egr3-mediated transcription in the brain. J. 

H. KIM*; S. BANDYOPADHYAY; A. R. BROOKS-KAYAL; S. 

J. RUSSEK. Boston Univ. Sch. of Med., Univ. of Colorado, 

Denver. 

4:00 F24 443.16 Engrailed: A nexus point between brain 

development and GABAR expression. M. COGSWELL*; Z. 

XIE; S. J. RUSSEK. Boston Univ. 

1:00 F25 443.17 Loss of GABA-A receptor α4 subunit 

expression in the pons alters the respiratory pattern and motor 

function of mutant mice. R. E. SIEGEL*; A. M. STEVENS; 

J. LORIA; E. CRUMMY; G. CASADESUS; T. E. DICK. Case 

Western Reserve Univ. Sch. Med. 


2:00 F26 443.18 Spontaneous neocortical and hippocampal 

early network oscillations in newborn rat brain slices depend 

critically on extracellular Ca 2+ /K + antagonism. C. KANTOR; J. 

KURIBAYASHI; B. PANAITESCU; A. RUANGKITTISAKUL; K. 

BALLANYI*. Univ. Alberta. 

POSTER 

444. Adenosine and ATP: Basic and Translational Research 


Mechanisms 


1:00 F27 444.1 Anti-depressive effects of sleep 

deprivation require the astrocyte-dependent sleep-homeostat. 

D. J. HINES*; L. I. SCHMITT; R. M. HINES; P. G. HAYDON. 

Tufts Univ. Sch. of Med. 

2:00 F28 444.2 The basic mechanism of a ketogenic diet: 

A purinergic autocrine regulation of CA3 pyramidal neurons? 

M. KAWAMURA*; D. N. RUSKIN; S. A. MASINO. Jikei Univ. 

Sch. Med., Trinity Col. 

3:00 F29 444.3 Neuromuscular transmission and ageing: 

The role of adenosine. P. A. POUSINHA*; A. M. CORREIA; 

A. M. SEBASTIÃO; J. A. RIBEIRO. IMM, Fac. Medicine, UL, 

Museu Nacional de História Natural, Univ. de Lisboa. 

4:00 F30 444.4 • Altered thermoregulation via sensitization 

of A1 adenosine receptors in dietary-restricted rats. T. R. 

JINKA*; Z. A. CARLSON; J. T. MOORE; K. L. DREW. Univ. 

Alaska, Fairbanks, Univ. of LAaska Fairbanks. 

1:00 F31 444.5 In vivo modulation of adenosine A1 

receptor expression in the chick embryo retina. K. C. 

CALAZA*; R. S. BRITO; M. R. PEREIRA; R. PAES-DE- 

CARVALHO. UFF. 

2:00 F32 444.6 The pattern of ATP release from nerve 

terminals triggers a feed-forward facilitatory loop operated by 

adenosine A2A receptor activation to assist implementation of 

frequency-dependent plastic changes. R. A. CUNHA*; R. J. 

RODRIGUES; E. AUGUSTO; J. P. OSES; T. ALMEIDA; H. B. 

SILVA; A. R. TOME; P. M. AGOSTINHO. Inst. Biochem, Fac 

Med, Univ. Coimbra. 

3:00 F33 444.7 • Enabling structure-based drug discovery 

using thermostabilised adenosine A 2A receptors (StaRs). C. J. 

LANGMEAD*; A. BAIG; E. HURRELL; A. ZHUKOV; A. DORE; 

N. ROBERTSON; J. ERREY; B. TEHAN; M. CONGREVE; F. 

MARSHALL. Heptares Therapeut. 

4:00 F34 444.8 Coordinated down-regulation of 

lipopolysarccharides-induced microglial activation by the 

adenosine A 1 and A 2A receptors in mouse striatum. J. 

CHEN*; L. YU; J. COELHO; M. A. SCHWARZSCHILD; B. B. 

FREDHOLM. Boston Univ. Sch. Med., Boston Univ. Sch. of 

Med., Massachusetts Gen. Hosp., Karolinska Inst. 

1:00 F35 444.9 Effect of potassium supplementation 

on adenosine dynamics with re-oxygenation in a culture of 

astrocytes. T. B. KULIK*; E. GREENBERG; H. R. WINN. Univ. 

of Rochester Med. Ctr., Mount Sinai Sch. of Med., Mount Sinai 

Med. Ctr. 

2:00 F36 444.10 Role of K+ channels on the expression 

of dependence from receptor A1-stimulation in guinea pig 

ileum (GPI). A. MANDUCA; E. MHILLAJ; V. TREZZA*; M. 

PALMERY; P. VALERI. Univ. Sapienza, Univ. RomaTre. 

3:00 F37 444.11 Mechanisms underlying upregulation of 

microglial P2Y6 receptors. S. KOIZUMI*; K. FUJISHITA; A. 

NAKAO. Univ. Yamanashi. 



4:00 F38 444.12 The rat A 2A adenosine receptor gene: A 

dual-coding gene. C. LEE*; C. CHIEN; Y. LEE; Y. CHERN. 

Academia Sinica, Natl. Yang-Ming Univ., Natl. Def. Med. Ctr., 

Natl. Cheng Kung Univ. 

POSTER 

445. Sodium Channel Physiology II 


Mechanisms 


1:00 F39 445.1 Serotoninergic modulation of action 

potential backpropagation. W. HU*; C. TIAN; Y. SHU. 

INSTITUTE OF NEUROSCIENCE, CHINESE ACADMEY OF 

SCIENCE. 

2:00 F40 445.2 Sodium channel auxiliary subunit β-4 

(Navβ4) is enriched at axon initial segments and at nodes of 

Ranvier. S. A. BUFFINGTON*; M. N. RASBAND. Baylor Col. 

of Med. 

3:00 F41 445.3 CCL2 modulates Nav1.8 sodium channel 

activity in dorsal root ganglia neurons. M. BELKOUCH*; V. 

BEGIN-LAVALLEE; N. BEAUDET; A. CHRAIBI; S. MELIK- 

PARSADANIANTZ; P. SARRET. Univ. De Sherbrooke, Ctr. de 

recherche de l’Institut Cerveau Moelle (Cr ICM) UMR S 975 

INSERM- UMR 7225 CNRS- UPMC Faculté de Médecine 

Pitié Salpêtrière. 

4:00 F42 445.4 Nav1.7 mutations associated with 

paroxysmal extreme pain disorder produce resurgent sodium 

currents in human embryonic kidney cells. J. W. THEILE*; B. 

W. JARECKI; T. R. CUMMINS. Indiana Univ. Sch. of Med. 

1:00 F43 445.5 Nav1.9 regulates axon growth in cultured 

embryonic motoneurons. N. SUBRAMANIAN*; B. DOMBERT; 

S. JABLONKA; R. BLUM; M. SENDTNER. Inst. of Clin. 

Neurobio., Julius-Maximilians-University. 

2:00 F44 445.6 Structural conservation of toxin-binding 

motif in sodium channel domain-II and domain-IV detected 

with HWTX-IV. Y. XIAO; S. LIANG; T. R. CUMMINS*. Indiana 

Univ. Sch. Med., Hunan Normal Univ. 

3:00 F45 445.7 Altered voltage-gated sodium channel 

properties following contusive spinal cord injury. A. PIEKARZ*; 

N. LIU; J. O. JACKSON, Jr.; X. XU; G. D. NICOL; T. R. 

CUMMINS. Indiana Univ. Sch. Med. 

4:00 F46 445.8 Isoform-specific regulation of sodium 

channel Nav1.6 by p38 MAP kinase requires two Nedd4 

binding sites. A. GASSER*; X. CHENG; E. S. GILMORE; L. C. 

TYRRELL; S. G. WAXMAN; S. D. DIB-HAJJ. Yale Univ. Sch. 

of Med., Veterans Admin. Connecticut Healthcare Syst. 

1:00 F47 445.9 Mechanisms for nerve conduction block 

produced by α 2 adrenoceptor agonist dexmedetomidine 

in frog sciatic nerves. K. MIZUTA; T. KOSUGI; T. FUJITA; 

H. YUE; L. PIAO; Y. UEMURA; M. INOUE; T. YASAKA; S. 

MASUKO*; E. KUMAMOTO. Dept. Physiol., Fac. Med., Saga 

Univ., Dept. Palliative Care, Saga Prefect. Hosp. Koseikan, 

Dept. Anesthesiol., Fac. Med., Saga Univ., Saga Med. Sch. 



2:00 F48 445.10 Linalool blocks excitability in peripheral 

nerves and voltage-dependent Na+ current in dissociated 

dorsal root ganglia neurons. K. S. SILVA-ALVES; F. W. 

FERREIRA-DA-SILVA; T. SANTOS-NASCIMENTO; H. C. 

JOCA; F. H. P. MACEDO; E. D. LINHARES-SIQUEIRA; 

M. LEMOS-DOS-SANTOS; M. B. OQUENDO; P. M. 

ALBUQUERQUE-NETO; P. J. C. MAGALHÃES; V. M. 

CECCATTO; S. LAHLOU; J. S. CRUZ; R. BARBOSA*; J. 

H. LEAL-CARDOSO. State Univ. of Ceará, Federal Univ. 

of Ceará, Federal Univ. of Minas Gerais, Inst. Superior de 

Ciências Biomédicas. 

3:00 F49 445.11 Biosynthesis of GPI-anchored proteins is 

necessary for proper sodium channel expression in zebrafish 

Rohon-Beard neurons to respond to mechanosensory 

stimulation. H. HIRATA*. Nagoya Univ. 

4:00 F50 445.12 • Cell type-specific expression of acidsensing 

ion channels in hippocampal interneurons. C. LIEN*; 

J. WENG. Natl. Yang-Ming Univ. 

1:00 F51 445.13 Calcium-permeable acid-sensing ion 

channels in NG2 glia of rat hippocampus. Y. LIN*; Y. LIU; C. 

LIEN. Natl. Yang-Ming Univ. 

2:00 F52 445.14 Antinociceptive effect of Thalassia 

testudium extract (BM-21) is mediated by inhibition of the 

ASIC current by phenolic compound thalassiolin-B. E. SOTO*; 

E. SALCEDA; R. MENÉNDEZ; E. REGALADO; O. LOPEZ; 

T. GARCÍA; R. A. MORALES; A. LAGUNA; O. P. THOMAS; 

A. GARATEIX. Univ. Autonoma De Puebla, Univ. Autonoma 

de Puebla, Ctr. de Bioproductos Marinos, Agencia de Medio 

Ambiente, Univ. de Nice-Sophia Antipolis. 

3:00 F53 445.15 Voltage-gate proton channel, HV1, 

contributes to production of reactive oxygen species in mouse 

hippocampal microglia. L. WU*; G. WU; E. P. FEENER; D. E. 

CLAPHAM. Harvard Med. Sch., Havard Med. Sch. 

4:00 F54 445.16 UNC-79 and UNC-80 are required for 

NCA-1 function. P. CHEN*; G. ERNSTROM; S. WATANABE; 

E. JORGENSEN. Dept. of Biology, Univ. of Utah, Howard 

Hughes Med. Inst. 

POSTER 

446. Potassium Channel Physiology II 


Mechanisms 


1:00 F55 446.1 Potassium currents in wild-type and dunce 

drosophila neurons. W. B. ALSHUAIB*; M. Y. HASAN; M. A. 

FAHIM. Kuwait Univ., UAE Univ. 

2:00 F56 446.2 Enhanced Kv1 channel function may 

contribute to reduced sIPSC frequency following chronic 

inhibition of NR2B-containing NMDAR with Ro25,6981. S. B. 

BAUSCH*; S. HE. Uniformed Services Univ. 

3:00 F57 446.3 Kv1 channels control spike threshold 

dynamics in cortical pyramidal neurons. M. H. HIGGS*; 

W. J. SPAIN. VA Puget Sound Hlth. Care Syst., Univ. of 

Washington. 

4:00 F58 446.4 Circadian deficits exhibited by mice 

lacking both the Kv3.1 and Kv3.2 potassium channels. T. 

KUDO; D. H. LOH; C. S. COLWELL*. UCLA. 


Mon. PM

1:00 G1 446.5 Kv3 subunits contribute substantially to 

the delayed rectifier K + current (I K ) in small mouse dorsal 

root ganglion (DRG) neurons. E. BOCKSTEINS*; G. VAN 

DE VIJVER; P. VAN BOGAERT; D. J. SNYDERS. Univ. of 

Antwerp. 

2:00 G2 446.6 The Cav3-Kv4 signaling complex functions 

as a calcium sensor to control cerebellar stellate cell gain. D. 

M. ANDERSON*; J. D. T. ENGBERS; W. H. MEHAFFEY; G. 

W. ZAMPONI; R. W. TURNER. Univ. of Calgary, Keck Ctr. for 

Integrative Neurosci. 

3:00 G3 446.7 Different roles for DPP6 N-terminal 

variants in regulating the electrophysiological properties of 

cerebellar granule cells. P. J. PFAFFINGER*; B. M. NADIN; H. 

H. JERNG. Baylor Col. of Med. 

4:00 G4 446.8 A-type K + channels encoded by Kv4.2, 

Kv4.3, and Kv1.4 differentially regulate intrinsic excitability in 

layer 5 cortical pyramidal neurons. Y. CARRASQUILLO*; J. 

M. NERBONNE. Washington Univ. Sch. of Med., Washington 


1:00 G5 446.9 Oliodendroglial differentiation is regulated 

by the resting membrane potential generated by KIR4.1 

inward rectifier channels. D. H. FELDMAN*; M. HORIUCHI; 

T. ITOH; D. PLEASURE. Shriners Hosp. for Children, Univ. of 

California, Davis, Sch. of Med. 

2:00 G6 446.10 Kv2.2 currents decline rapidly after 

deprivation of afferent activity. C. KOPP-SCHEINPFLUG; 

H. TONG*; J. R. STEINERT; S. M. YOUNG, Jr; S. W. 

ROBINSON; I. D. FORSYTHE. Univ. of Leicester, Max Planck 

Florida Inst. 

3:00 G7 446.11 Modulation of Kv2.1 channels by transient 

chemical ischemia. R. C. FOEHRING*; D. GUAN. Univ. 

Tennessee Hlth. Sci., Univ. of Tennessee HSC. 

4:00 G8 446.12 Molecular dissection of Kv2.1 channel 

function and localization. K. M. O’CONNELL*. Univ. 

Tennessee Hlth. Sci. Ctr. 

1:00 G9 446.13 The role of cyclin dependent kinases 

(CDKs) in phosphorylating neuronal Kv2.1 channels. O. A. 

CERDA*; J. AGUADO; J. S. TRIMMER. Univ. of California 

Davis. 

2:00 G10 446.14 Distinct expression of KCNH1 in regions 

related to motor- and behavior control and KCNH5 in regions 

involved in olfaction. G. KUSCHER; R. UFARTES; A. 

NITYANANDAM*; L. A. PARDO; W. STUEHMER; F. ALVES. 

MPI Exptl. Med. 

3:00 G11 446.15 A conserved Threonine in the S1-S2 

loop of Kv7.2/7.3 is important for voltage-dependent channel 

activation. Y. FÜLL; H. LERCHE*; S. MALJEVIC. Univ. Hosp. 

Tuebingen. 

4:00 G12 446.16 Characterization of the axon initial 

segment (AIS) of motoneurons and identification of a 

para- and a juxtapara-AIS. A. DUFLOCQ*; B. LE BRAS; E. 

BULLIER; F. COURAUD; M. DAVENNE. Univ. Pierre Et Marie 

Curie - Paris 6, INSERM Umrs952, CNRS Umr7224. 

1:00 G13 446.17 Are sodium-activated potassium channels 

“gatekeepers” of synaptic information? T. A. HAGE; L. B. 

SALKOFF*. Washington Univ. Sch. Med. 

2:00 G14 446.18 An unrecognized role for substance P in 

muscle afferent DRG neurons. C. J. LIN*; Y. LIN; C. CHEN. 

Academia Sinica, Natl. Yang-Ming Univ., Col. of Chinese 

Med. 


4:00 G15 446.19 The role of the acid-sensing ion channels- 

1α in the regulation of neuronal excitability in the rat 

amygdala. V. PIDOPLICHKO; F. QASHU*; V. ARONIADOU- 

ANDERJASKA; M. F. M. BRAGA. Uniformed Services Univ. 

3:00 G16 446.20 Kv4 is essential for maintaining excitability 

during repetitive firing of Drosophila neurons, and normal 

locomotion. Y. PING; G. WARO; A. LICURSI; D. VO-BA; S. L. 

TSUNODA*. Colorado State Univ. 

1:00 G17 446.21 � Voltage activated currents in zebrafish 

hair cells. P. BRAVO; B. ESCOBAR; J. MAGANA; M. 

MALINAO; J. NGO; O. SANCHEZ; A. TUCKER; M. VALDIVIA; 

S. YAGHTIN; V. ZERON; B. E. YAZEJIAN*. Mount St. Mary’s 

Col. 

2:00 G18 446.22 The phosphoserine binding protein 14-3- 

3β is required for PKC-mediated trafficking of the potassium 

leak channel KCNK3 (TASK-1). L. R. GABRIEL*; A. LVOV; W. 

R. KOBERTZ; H. E. MELIKIAN. UMass Med. Sch. 

POSTER 

447. Neurotransmitter Release: Calcium-Dependence 


Mechanisms 


1:00 G19 447.1 5-HT1B receptors target the SNARE 

complex at the CA1-subiculum synapse to filter synaptic 

transmission. E. Y. HAMID*; S. ALFORD. Univ. Illinois, 

Chicago. 

2:00 G20 447.2 Vertebrate-specific presynaptic protein 

Mover controls release probability at the calyx of Held. C. 

KÖRBER*; D. SCHWENGER; T. KREMER; T. DRESBACH; T. 

KUNER. Univ. of Heidelberg. 

3:00 G21 447.3 Hemiplegic migraine gene mutation 

links spontaneous neurotransmission to stochastic opening 

of presynaptic voltage-gated calcium channels. F. G. 

ALDER; R. SURGES; I. PAVLOV; A. M. J. M. VAN DEN 

MAAGDENBERG; D. M. KULLMANN; K. E. VOLYNSKI*. 

UCL, Leiden Univ. Med. Ctr. 

4:00 G22 447.4 Calcium triggering of neuronal somatic 

exocytosis of serotonin. C. LEON PINZON*; P. L. NOGUEZ; 

M. G. CERCÓS; C. TRUETA; F. F. DE MIGUEL. Inst. de 

Fisiología Celular-Neurociencias, UNAM, Inst. Nacional de 

Psiquiatría Ramón de la Fuente. 

1:00 G23 447.5 α1-adrenergic neuromodulation of 

spontaneous transmitter release in layer ii/iii of rat barrel 

cortex. J. CHOY*; L. LI; C. STRICKER. The John Curtin Sch. 

of Med. Res., Sch. of Medicine, Xi’an Jiaotong Univ., The 

Australian Natl. Univ. 

2:00 G24 447.6 Reliability in mammalian neuromuscular 

transmission maintained by distributed excess release sites 

and presynaptic nicotinic acetylcholine receptors. T. TARR*; S. 

KENNON; F. ALIYU; S. MERINEY. Univ. of Pittsburgh. 

3:00 G25 447.7 Regulation of synaptic vesicle exocytosis 

and calcium influx by Erk1/2. J. SUBRAMANIAN*; A. 

MOROZOV. NIH. 

4:00 G26 447.8 Contribution of intracellular calcium 

stores to serotonin release from different vesicular pools. 

M. GUERRERO*; C. LEÓN-PINZÓN; F. F. DE-MIGUEL; C. 

TRUETA. Inst. Nacional de Psiquiatría Ramón de la Fuente, 

Inst. de Fisiología Celular-Neurociencias, UNAM. 



1:00 G27 447.9 Altered electroresponsiveness of striatal 

fast-spiking interneurons from parvalbumin knock-out mice. D. 

ORDUZ*; P. BISCHOP; B. SCHWALLER; S. SCHIFFMANN; 

D. GALL. Univ. Libre de Bruxelles, Fribourg Univ. 

2:00 G28 447.10 Characterization of Ca 2+ signaling 

pathways in mouse adrenal medullary chromaffin cells. 

P. WU*; M. FANN; L. KAO. Dept. of Life Sci. and Inst. of 

Genome Sciences, Natl. Yang-Ming Uni, Mol. Med. Program, 

Natl. Yang-Ming Uni., Inst. of Neuroscience, Natl. Yang-Ming 

Uni. 

3:00 G29 447.11 Leu 27 IGF-II, an IGF-II analog, attenuates 

depolarization-evoked GABA release from adult rat 

hippocampal and cortical slices. S. KAR*; A. AMRITRAJ; G. 

RAUW; G. BAKER. Univ. Alberta. 

4:00 G30 447.12 Imaging Ca2+ dynamics in posterior 

pituitary nerve terminals using two photon fluorescence 

microscopy. S. MCMAHON*; M. JACKSON. Univ. of 

Wisconsin - Madison. 

POSTER 

448. Synaptic Transmission: Presynaptic Structure and 

function 


Mechanisms 


1:00 G31 448.1 Neurochemical signature for the different 

extrinsic afferents innervating the supragranular layer of the 

rat dentate gyrus. R. SOUSSI*; E. BASSOT; M. ESCLAPEZ. 

INSERM U751, Aix-Marseille Univ. 

2:00 G32 448.2 Piccolo regulates the dynamic assembly 

of presynaptic F-actin. C. WAITES*; S. A. LEAL-ORTIZ; T. F. 

M. ANDLAUER; S. SIGRIST; C. C. GARNER. Stanford Univ. 

Sch. of Med., Univ. of Wurzburg, Free Univ. Berlin. 

3:00 G33 448.3 Functional properties of presynaptic 

voltage-gated Ca 2+ channels expressed at the endbulb of 

Held synapse. K. LIN*; I. CHEN; H. TASCHENBERGER. Max 

Planck Inst. for Biophysical Chem. 

4:00 G34 448.4 Properties of fusion-competent mobile 

synaptic vesicles in hippocampal neurons. K. STARAS*; A. 

RATNAYAKA; V. MARRA; T. BRANCO; D. BUSH. Univ. of 

Sussex, Univ. Col. London. 

1:00 G35 448.5 Stochastic modeling of vesicular release 

at hippocampal synapses. S. NADKARNI*; T. M. BARTOL, Jr; 

T. J. SEJNOWSKI; H. LEVINE. UC San Diego, Salk Inst. for 

Biol. Studies. 

2:00 G36 448.6 Serotonergic axon terminals with 

glutamatergic phenotype make synapses on both 

dopaminergic and nondopaminergic neurons in the ventral 

tegmental area. S. ZHANG*; M. MORALES. Natl. Inst. of 

Health, Natl. Inst. on Drug Abuse, IRP. 

3:00 G37 448.7 Nerve terminal nAChRs initiate quantal 

GABA release by activating axonal T-type (Cav3.x) Ca 2+ 

channels and Ca 2+ release from stores. A. TANG*; M. A. 

KARSON; J. M. MCINTOSH; B. E. ALGER. Univ. of Maryland 

Sch. of Med., Univ. of Utah. 

4:00 G38 448.8 • Physical exercise in adolescence 

changes CB1 cannabinoid receptor expression in the rat 

brain. S. GOMES DA SILVA*; B. H. S. ARAUJO; A. C. 

COSSA; F. A. SCORZA; E. A. CAVALHEIRO; M. NAFFAH- 

MAZZACORATTI; R. M. ARIDA. Dept. of Physiology. Univ. 

Federal de São Paulo. 



1:00 G39 448.9 DOPAC regulation in dopaminergic axon 

terminals: A computational analysis. L. J. WALLACE*; J. S. 

TRAEGER. Ohio State Univ. 

2:00 G40 448.10 • Functional interaction of synapsin II and 

Rab3a at hippocampal synapses. M. B. KOZHEMYAKIN*; M. 

BYKHOVSKAIA. Univ. Central Del Caribe. 

3:00 G41 448.11 Computational study of active zone 

structure and function at the mammalian neuromuscular 

junction. J. MA; M. DITTRICH*; T. TARR; S. D. MERINEY; J. 

R. STILES. Carnegie Mellon Univ., Univ. of Pittsburgh. 

4:00 G42 448.12 Determination of GABAergic functioning 

in prefrontal cortex of early postnatal PCP rats. C. J. K. 

HANSEN; B. V. BROBERG; U. KRISTIANSEN*; N. DALBY. 

Univ. Copenhagen, FARMA, H. Lundbeck A/S, Univ. 

Copenhagen, SUND. 

1:00 G43 448.13 Ultrastructural organization of presynaptic 

vesicles. B. WALTERS; J. CRUM; M. E. MARTONE; M. H. 

ELLISMAN; R. J. WEINBERG; M. NIETHAMMER; A. C. 

BURETTE*. Univ. of North Carolina, Univ. of California. 

2:00 G44 448.14 Impaired presynaptic structure and 

function in area CA1 of symptomatic Mecp2 null mice may not 

account for hippocampal hyperexcitability. G. D. CALFA*; M. 

D. AMARAL; J. HABLITZ; L. POZZO-MILLER. UAB. 

3:00 G45 448.15 BK-Cav complexes and submicron 

synaptic organization compartmentalize signaling within a 

retinal feedback microcircuit. W. N. GRIMES; J. ZHANG; H. 

TIAN; J. S. DIAMOND*. NIH/NINDS/SPS, NIH/NINDS/SPU. 

4:00 G46 448.16 Presynaptic synthesis of anandamide 

underlies chronic suppression of inhibition at CCK-positive 

interneuron to CA1 pyramidal cell synapses. C. FALCONER*; 

A. BOLSHAKOV; C. HOLMGREN; A. ROZOV. Inst. Für 

Psychologie Univ. Bern, Univ. of Dundee. 

1:00 G47 448.17 • Quantitative ultrastructural analysis 

of commissural/associational CA3 synapses. T. A. 

SCHIKORSKI*; L. QU. Univ. Central Del Caribe, Vanderbilt 

Univ. 

2:00 G48 448.18 Differential GAD65 and GAD67 expression 

in somatostatin-positive axon terminals. B. R. ROCCO; K. 

FISH*. Univ. Pittsburgh. 

3:00 G49 448.19 Bassoon speeds vesicle reloading at 

a central excitatory synapse. S. J. HALLERMANN*; A. 

FEJTOVA; H. SCHMIDT; A. WEYHERSMÜLLER; R. A. 

SILVER; E. GUNDELFINGER; J. EILERS. Carl-ludwig- 

Institute of Physiol., Leibniz Inst. for Neurobio., Univ. Col. 

London. 

4:00 G50 448.20 Synapsin isoforms regulate short-term 

plasticity at the calyx of Held. M. VASILEVA*; R. RENDEN; D. 

GITLER; T. KUNER. Univ. of Heidelberg, Ben Gurion Univ. of 

the Negev. 

1:00 G51 448.21 Differential synaptic transmission between 

hippocampal mossy fiber boutons and different types of 

postsynaptic target cells. S. BOUDKKAZI; P. JONAS*. 

Physiological Inst., Inst. of Sci. and Technol. (IST). 

2:00 G52 448.22 Different correlations among functional 

and morphological properties at single glutamatergic synapse 

in the hippocampus and the cerebellum. H. MIYAWAKI*; T. 

HIRANO. Grad. Sch. of Science, Kyoto Univ. 

3:00 G53 448.23 Inter- and intracolumnar desynchronization 

by presynaptic GABA B inhibition in the rat barrel cortex. M. 

SAITO*; H. SATO; H. TOYODA; M. KOBAYASHI; D. ALTHOF; 

A. KULIK; R. SHIGEMOTO; Y. KANG. Osaka Univ. Grad. Sch. 

Dent., Univ. Freiburg, Nat. Inst. Physiol. Scis. 


Mon. PM

4:00 G54 448.24 Molecular basis of the regulation of 

neuronal and non-neuronal focal adhesion kinase (FAK). 

K. BRAMI-CHERRIER*; S. AROLD; M. BOUTTERIN; G. 

KADARE; L. GASMI; J. GIRAULT. Inst. Du Fer À Moulin/ 

Umrs 839, Inst. Natl. de la Santé et de la Recherche Médicale 

(INSERM),, Univ. Pierre et Marie Curie-Paris 6, CNRS, UT M. 

D. Anderson Cancer Ctr. 

POSTER 

449. Synaptic Transmission: Postsynaptic Structure and 

function 


Mechanisms 


1:00 G55 449.1 In vivo observation of neuromuscular 

synapse transition using transgenic zebrafish lines. J. PARK*; 

T. IKENAGA; F. ONO. NIH/NIAAA. 

2:00 G56 449.2 Unexpected increase in “inhibitory” 

Neuroligin 2 association with excitatory scaffolding protein 

PSD95 in neuropathic rats. T. DOLIQUE; A. FAVEREAUX; 

V. ROQUES; C. LEGER; M. LANDRY; F. NAGY*. INSERM 

U862, Bordeaux Univ. 

3:00 G57 449.3 Identification of neurochondrin/norbin as 

a palmitoylated synaptic protein. S. OKU*; J. NORITAKE; 

T. IWANAGA; Y. FUKATA; M. FUKATA. Natl. Inst. For 

Physiological Sci., The Grad. Univ. for Advanced Studies 

(SOKENDAI), PRESTO, Japan Sci. and Technol. Agency. 

4:00 G58 449.4 Characterization of Slitrk4 in the central 

nervous system. M. A. SAHAWNEH*; S. V. SHMELKOV; I. 

DINCHEVA; D. JING; F. S. LEE. Weill Cornell Med. Col. 

1:00 H1 449.5 Development of dentate granule cells in 

organotypic slice cultures: A comparison with granule cells in 

acute slices. C. J. GILBRIDE; X. WANG; F. A. EDWARDS*. 

Univ. Col. London, Univ. of Reading. 

2:00 H2 449.6 Differential response of alpha7- and 

alpha3-containing nicotinic receptors to spillover of 

acetylcholine. D. STANCHEV; P. B. SARGENT*. UC San 

Francisco. 

3:00 H3 449.7 Neurobeachin: An AKAP involved in the 

regulation of glutamatergic receptors. J. LAUKS*; R. NAIR; N. 

E. COOKE; J. RHEE; M. VERHAGE. CNCR, VU Univ., Max 

Planck Inst. for Exptl. Med., Univ. of Pennsylvania. 

4:00 H4 449.8 Cdc42 cooperates with collybistin to 

regulate gephyrin trafficking and clustering at GABAergic 

synapses. H. H. GHOSH*; S. K. TYAGARAJAN; K. HARVEY; 

J. FRITSCHY. Pharmacol. and Toxicology Institute, Univ. of 

Zurich, Univ. of London. 

1:00 H5 449.9 Association of membrane rafts and 

postsynaptic density: Proteomics, biochemical, and 

ultrastructural analyses. T. SUZUKI*; J. ZHANG; S. 

MIYAZAWA; Q. LIU; M. R. FARZAN; W. YAO. Shinshu Univ. 

Grad. Sch. Med., Harvard Med. Sch. & New England Primate 

Res. Ctr. 

2:00 H6 449.10 NMDA receptor-dependent regulation of 

dendritic spine morphology by SAP102 splice variants. B. 

CHEN*; E. V. THOMAS; K. W. ROCHE. Med. Col. of Georgia, 

Yale Univ., NINDS. 

3:00 H7 449.11 Regulation of neuronal structure and 

function by Neuroligin-1. H. KWON*; N. SINDHI; B. L. 

SABATINI. Harvard Med. Sch. 


4:00 H8 449.12 Morphological analysis of neurons 

in cortactin deficient mice. S. TANAKA*; A. HARADA; S. 

OKABE. Dept. of Cell. Neurobiology, Univ. Tokyo, Dept. of Cell 

Biology, Osaka Univ. 

1:00 H9 449.13 Photochemical inactivation of postsynaptic 

AMPA receptors in hippocampal slices. H. KAMIYA*. Hokkaido 

Univ. Grad. Sch. of Med. 

2:00 H10 449.14 Differential vesicular sorting of AMPA and 

GABAA receptors during exocytosis. Y. GU*; D. LIN; R. L. 

HUGANIR. Johns Hopkins Med. Sch., The Jackson Lab. 

3:00 H11 449.15 Generation of PSD95-EGFP reporter 

knockin mice by gene targeting strategy: A powerful tool for 

synaptic biology. F. ZHU*; N. H. KOMIYAMA; S. G. N. GRANT. 

Genome Res. Limited. 

4:00 H12 449.16 Three-dimensional analysis of the spine 

apparatus in the molecular layer of rat hippocampal dentate 

gyrus. M. KUWAJIMA*; A. E. POHODICH; J. B. BOWDEN; P. 

H. PARKER; W. C. ABRAHAM; K. M. HARRIS. Univ. Texas, 

Austin, Univ. Otago. 

1:00 H13 449.17 The K-Cl cotransporter KCC2 

constrains spine volume and postsynaptic receptor content 

in hippocampal neurons. G. GAUVAIN; I. CHAMMA; T. 

EIRINOPOULOU; C. CABEZAS; S. LÉVI; J. PONCER*. 

INSERM, Univ. Pierre & Marie Curie. 

2:00 H14 449.18 NMDA-mediated translocation of SPIN90 

regulates long-term depression in cultured hippocampal 

neurons. I. CHO; S. KIM; K. CHOI; M. LEE; J. BAE; W. 

SONG*. Gwangju Inst. of Sci. and Technol. (GIST), Emory 

university, Natl. Inst. of Neurolog. Disoreders and Stroke. 

3:00 H15 449.19 Histone modifications are involved in 

chronic intermittent ethanol treatment-induced regulation 

of the NMDA receptor 2B gene. M. QIANG*; M. LIEU; A. 

DENNY; J. LI. Univ. Texas. 

4:00 H16 449.20 Activity-dependent regulation of the K/ 

Cl transporter KCC2 membrane dynamics in hippocampal 

neurons. I. CHAMMA; C. EMMANUELLI; M. CARNAUD; J. 

PONCER; S. LÉVI*. INSERM, Univ. Pierre & Marie Curie. 

1:00 H17 449.21 • NMDA receptor NR2 

subfunctionalisation: Implications for synaptic plasticity and 

the evolution of behaviour. T. J. RYAN*; N. H. KOMIYAMA; 

M. V. KOPANITSA; T. INDERSMITTEN; B. JANSSEN; N. 

AFINOWI; J. NITHIANANTHARAJAH; L. E. STANFORD; E. 

J. TUCK; J. MORRISON; T. J. BUSSEY; L. M. SAKSIDA; T. J. 

O’DELL; S. G. N. GRANT. Wellcome Trust Sanger Inst., Dept. 

of Neurology, U.C.L.A., Mount Sinai Sch. of Med., Univ. of 

Cambridge, David Geffen Sch. of Medicine, U.C.L.A. 

2:00 H18 449.22 Agrin induces a subsynaptic microtubule 

network that is involved in AChR clustering. N. P. HARDEL*; 

S. GATTI; S. SLADECEK; N. GALJART; H. R. BRENNER. 

Dept. of Biomedicine/Physiology, Dept. of Cell Biol. and 

Genet. 

3:00 H19 449.23 Synapse-specific inhibitory control of 

hippocampal feedback inhibitory circuit. S. CHAMBERLAND*; 

C. SALESSE; D. TOPOLNIK; T. POKIDCHENKO; L. 

TOPOLNIK. CRULRG, Univ. Laval. 

4:00 H20 449.24 Novel interaction of spinophilin and 

calcium/calmodulin-dependent protein kinase II is regulated 

during aging. A. J. BAUCUM II*; R. J. COLBRAN. Vanderbilt 

Univ. 

1:00 H21 449.25 BRAG1/IQSEC2, a guanine nucleotide 

exchange factor implicated in non-syndromic mental 

impairment, regulates dendritic spine morphology. J. A. 

MURPHY; C. LIM; R. S. WALIKONIS*. Univ. of Connecticut. 



2:00 H22 449.26 Light-induced structural changes in 

rod photoreceptor ribbon synapses. G. A. ZAMPIGHI*; C. 

SCHIETROMA; L. ZAMPIGHI; N. BRECHA. UCLA Sch. Med. 

POSTER 

450. Synaptic Transmission: Synaptic Integration 


Mechanisms 


1:00 H23 450.1 Neuronal dendritic changes and dendritic 

spines alterations after treatment with the pneumococcal 

neurotoxin pneumolysin. C. A. WIPPEL*; A. I. ILIEV; T. J. 

MITCHELL. Univ. of Wuerzburg, Univ. of Glasgow. 

2:00 H24 450.2 General rules for autapse and 

heterosynapse formation and function in mini neuronal 

circuits. C. CHANG*; C. ROSENMUND. Baylor Col. of Med., 

Neurocure NWFZ, Charite Universitaetsmedizin. 

3:00 H25 450.3 Somatic membrane potential and 4-AP 

sensitive K+ currents control action potential duration in axon 

collaterals and presynaptic boutons of cortical pyramidal 

neurons. A. J. FOUST*; M. POPOVIC; D. ZECEVIC; D. A. 

MCCORMICK. Yale Univ. 

4:00 H26 450.4 Spatial profile of lesion-induced changes 

in GABAergic function and neuronal excitability in rat visual 

cortex. B. IMBROSCI; T. MITTMANN*; U. T. EYSEL. Ruhr- 

University Bochum. 

1:00 H27 450.5 Cholinergic basal forebrain axons produce 

fast and slow nicotinic receptor-mediated responses in cortical 

interneurons. S. E. ARROYO; S. P. BROWN; D. AZIZ; S. 

HESTRIN*. Stanford Sch. of Med., Univ. of Arizona. 

2:00 H28 450.6 Highly compartmentalized excitatory 

synaptic integration in distal tuft dendrites of cortical layer 5 

neurons. M. T. HARNETT*; S. R. WILLIAMS; J. C. MAGEE. 

Janelia Farm Res. Campus, Howard Hughes Med. Inst., Univ. 

of Queensland. 

3:00 H29 450.7 A novel mechanism mediated by Group 

II mGluRs that contributes to the inhibition of hippocampal 

mossy fiber transmission. J. STER; C. CORTI; M. CORSI; 

U. GERBER*. Univ. Zurich, Addiction & Sleep DPU, 

GlaxoSmithKline S.p.A. 

4:00 H30 450.8 Dendritic dimensions and signal 

conduction properties of cortical nonpyramidal cells. Y. 

KUBOTA*; F. KARUBE; M. NOMURA; A. T. GULLEDGE; K. 

HASHIMOTO; A. MOCHIZUKI; Y. KAWAGUCHI. Natl. Inst. 

Physiol Sci. (NIPS), JST, CREST, SOKENDAI, Kyoto Univ., 

Dartmouth Med. Sch., RIKEN. 

1:00 H31 450.9 Distance-dependent postsynaptic 

regulation of short-term plasticity along thin dendrites of 

aspiny interneurons. T. ABRAHAMSSON*; L. CATHALA; D. 

DIGREGORIO. Inst. Pasteur, Univ. Paris Descartes. 

2:00 H32 450.10 Dendritic spikes and their effect on 

neuronal output in vivo. L. M. PALMER*; M. E. LARKUM. 

Univ. of Bern, Dept Physiol. 

3:00 H33 450.11 Cooperative action of excitatory synapses 

in thalamocortical cells. F. LAJEUNESSE*; H. KRÖGER; I. 

TIMOFEEV. Laval Univ. 

4:00 H34 450.12 Stochastic resonance improves weak 

signal detection in the pyramidal neurons of mouse visual 

cortex. M. UUSISAARI*; B. TORBEN-NIELSEN; B. GUTKIN; 

K. M. STIEFEL. Okinawa Inst. of Sci. and Technol., Ecole 

Normale Superieure. 



1:00 H35 450.13 Intraterminal human tau injection 

induces transmission failure at the squid giant synapse. H. 

W. MORENO; W. BERK; J. BRUSCO; J. E. MOREIRA; K. 

HIRATA; J. AVILA; M. SUGIMORI*; R. R. LLINAS. SUNY 

Downstate Med. Ctr., New York Univ, Sch. Med., Univ. of 

Riberao Preto, CIBERNED (CSIC-UAM). 

2:00 H36 450.14 Cooling activates developing hippocampal 

networks. E. DE LA PENA; A. MALKIA; C. BELMONTE; 

F. VIANA*. Univ. Miguel Hernandez UMH-CSIC, Inst. De 

Neurociencias UMH-CSIC. 

3:00 H37 450.15 Inhibition of dendritic activity in vivo. S. C. 

MURPHY; L. M. PALMER; M. MURAYAMA; M. E. LARKUM*. 

Univ. of Bern, Riken. 

4:00 H38 450.16 Scaled subtraction as a mechanism 

for gain control of Purkinje cell output. S. PARK*; K. 

KHODAKHAH. Albert Einstein. 

1:00 H39 450.17 • Cortical microcircuits and synaptic 

integration investigated with Digital Light Processing (DLP) 

photostimulation. J. P. JEROME*; D. HECK; R. FOEHRING; 

W. SPAIN. Univ. of Tennessee Hlth. Sci. Ctr., Univ. of 

Washington, VA Puget Sound Hlth. Care Syst. 

2:00 H40 450.18 • Different corticostriatal integration in 

spiny projection neurons from the direct and indirect pathways 

are modified by dopamine depletion. B. J. VIZCARRA- 

CHACÓN; E. FLORES-BARRERA; J. BARGAS; D. TAPIA; 

E. GALARRAGA*. Inst. de Fisiologia Celular-UNAM, Inst. 

Fisiologia Celular. 

3:00 H41 450.19 Uncaging glutamate near single dendritic 

spines elicits intracellular calcium waves and modifications 

in F-actin. P. A. GUSEV; H. W. JOHNSON; M. J. SCHELL*. 

Uniformed Services Univ. 

4:00 H42 450.20 Dendritic synaptic integration in mouse 

visual cortex in vivo. S. L. SMITH*; M. HAUSSER. Univ. Col. 

London. 

1:00 H43 450.21 Probing the role of inhibition in visual 

processing in vivo using optogenetic manipulation of 

interneuron activity. J. C. COTTAM*; S. L. SMITH; M. 

HAUSSER. Univ. Col. London. 

2:00 H44 450.22 Identification of candidate transsynaptically 

transported proteins. L. M. SCHIAPPARELLI*; J. 

LI; L. LIAO; D. B. MCCLATCHY; J. R. YATES, III; H. T. CLINE. 

The Scripps Res. Inst. 

POSTER 

451. Synaptic Plasticity: Short-Term Plasticity 


Mechanisms 


1:00 H45 451.1 The role of different calcium channel 

subtypes in synaptic dynamics and GABAB receptor-mediated 

presynaptic inhibition. U. M. RICOY*; M. FRERKING. OHSU. 

2:00 H46 451.2 Pregnenolone sulfate modulation 

of hippocampal frequency filtering. C. S. SCULLIN; L. 

PARTRIDGE*. Univ. New Mexico. 

3:00 H47 451.3 Reliability and maintenance of broadband 

transmission at central vestibular nerve synapses. L. E. 

MCELVAIN*; M. FAULSTICH; R. JACOBS; S. DU LAC. The 

Salk Inst., UC San Diego, Howard Hughes Med. Inst. 


Mon. PM

4:00 H48 451.4 Astrocyte-mediated short-term synaptic 

depression in the rat hippocampal CA1 area: Two modes 

of decreasing release probability. M. S. ANDERSSON*; E. 

HANSE. Gothenburg Univ. 

1:00 H49 451.5 The ubiquitin proteasome pathway 

modulates presynaptic architecture and controls short term 

synaptic plasticity. B. J. WALTERS; S. M. WILSON; L. E. 

DOBRUNZ*. Univ. of Alabama at Birmingham, Univ. Alabama 

@ Birmingham. 

2:00 H50 451.6 Calcium-dependent enhancement of 

release by subthreshold depolarization. J. M. CHRISTIE*; D. 

N. CHIU; C. E. JAHR. Max Planck Florida Inst., Oregon Hlth. 

and Sci. Univ. 

3:00 H51 451.7 Loss of Eag1 increases facilitation 

and spontaneous activity in cerebellar Purkinje cells. L. S. 

MORTENSEN; R. UFARTES; T. SAKABA; J. RHEE*; W. 

STÜHMER; L. A. PARDO. Max-Planck-Institute of Exptl. Med., 

Max-Planck-Institute of Biophysical Chem., Max-Plank Inst. for 

Exp Med. 

4:00 H52 451.8 Effects of weak direct current 

stimulation on synaptic plasticity in rat motor cortex in vitro; 

electrophysiological and molecular analysis of mechanisms. 

D. REATO*; A. RAHMAN; T. RADMAN; M. GLEICHMANN; 

M. BIKSON. City Col. of New York, Cognitive Neurosci. and 

Schizophrenia Program, Nathan Kline Inst. for Psychiatric 

Res., Lab. of Neurosciences, Natl. Inst. on Aging. 

1:00 H53 451.9 Short-term potentiation of inhibitory 

postsynaptic currents in magnocellular neurons of the 

supraoptic nucleus in the rat hypothalamus. L. A. MORTON*; 

I. R. POPESCU; J. G. TASKER. Tulane Univ. 

2:00 H54 451.10 A mechanism-based model for synaptic 

dynamics at Schaffer collateral synapses. A. H. TOLAND; M. 

E. FRERKING*. OHSU, PSU. 

3:00 H55 451.11 Multivesicular release differentiates the 

reliability of synaptic transmission between the visual cortex 

and the somatosensory cortex. C. HUANG*; T. SAKABA. MPI 

For Biophysical Chem. 

4:00 H56 451.12 Development of short-term synaptic 

plasticity in organotypic slices. W. CHEN*; D. V. 

BUONOMANO. UCLA. 

1:00 H57 451.13 Gene targeting of Nrxn2 reveals a role 

for β-neurexins in synaptic plasticity mediated by NMDA 

receptors. G. BORN*; L. MEDRIHAN; H. LANGHORST; 

K. NIESMANN; I. DUDANOVA; W. ZHANG; M. MISSLER. 

Wilhelms Univ. Münster, Inst. Italiano di Tecnologia, Max 

Planck Inst. of Neurobio. 

2:00 H58 451.14 Electrophysiological distinction of the 

medial and lateral perforant path inputs to the hippocampal 

dentate gyrus. T. S. KANNANGARA*; R. P. PETERSEN; J. D. 

SHIN; B. D. EADIE; B. R. CHRISTIE. Univ. Victoria, Univ. of 

British Columbia, Univ. of Victoria. 

3:00 H59 451.15 Influences of treadmill exercise on 

neuroblast differentiation at the acute and chronic stages 

in type 2 diabetes. S. NAM*; D. YOO; S. YI; W. SONG; J. 

CHOI; I. HWANG; M. WON; J. SEONG; Y. YOON. SEOUL 

NATIONAL UNIVERSITY, Marquette Univ., HALLYM 

UNIVERSITY. 


POSTER 

452. Synaptic Plasticity: LTP Kinases and Signaling 


Mechanisms 


1:00 H60 452.1 The role of STriatal-Enriched tyrosine 

Phosphatase (STEP) in aging mice. S. M. FERNANDEZ*; P. 

J. LOMBROSO. Yale Univ. 

2:00 H61 452.2 Repeated trial intermediate-term synaptic 

facilitation is attenuated by activity-dependent stimulation in 

Aplysia. S. J. FISCHBACH*; T. J. CAREW. Univ. of California - 

Irvine. 

3:00 H62 452.3 TNiK assembles postsynaptic signalling 

mechanisms involved in schizophrenia. M. P. COBA*; N. H. 

KOMIYAMA; M. V. KOPANITSA; J. NITHIANANTHARAJAH; 

L. STANFORD; T. INDERSMITTEN; L. SAKSIDA; T. BUSSEY; 

T. J. O’DELL; S. G. N. GRANT. Wellcome Trust Sanger Inst., 

UCLA, Univ. of Cambridge, David Geffen Sch. of Med. at 

UCLA. 

4:00 H63 452.4 Loss of striatal-enriched protein tyrosine 

phosphatase (STEP) reverses deficits in a fragile x syndrome 

mouse model. S. M. GOEBEL-GOODY*; E. D. WALLIS; L. LI; 

D. V. HALL; S. ROYSTON; M. BAUM; J. R. NAEGELE; P. J. 

LOMBROSO. Yale Univ., Wesleyan Univ. 

1:00 H64 452.5 The interaction between CaMKII and 

GluN2B is critical for contextual memory consolidation. I. S. 

STEIN*; A. R. HALT; R. F. DALLAPIAZZA; N. BROSE; J. W. 

HELL. UC Davis, Univ. of Iowa, Max Planck Inst. 

2:00 H65 452.6 Long-lasting potentiation of GluN 

receptors is required for the maintenance of a nondecrementing 

component of LTP at CA3-CA1 synapses. H. 

LI*; M. JACKSON; K. YANG; C. TREPANIER; B. ORSER; J. 

MACDONALD. Univ. of Western Ontario, Dept. of Anesthesia, 


3:00 H66 452.7 Genetic inhibition of dorsal striatal CaMKII 

generates “silent” synapses on medium spiny neurons and 

deficits in striatal-based learning. J. R. KLUG*; T. L. KASH; C. 

M. OLSEN; A. J. ROBISON; E. E. WATT; E. J. EPSTEIN; M. 

E. ANDERSON; R. J. COLBRAN; D. G. WINDER. Vanderbilt 

Univ., Univ. of North Carolina, Mount Sinai Sch. of Med., Univ. 

of Iowa. 

4:00 H67 452.8 Differential regulation of GluA1 

phosphorylation and potential metaplastic consequences. E. 

E. GRAY*; T. J. O’DELL. UCLA. 

1:00 H68 452.9 Analysis of PKMzeta motility and turnover 

using photoactivatable fluorescent Dendra2-PKMzeta 

fusion protein. P. S. VAN DE NES*; T. C. SACKTOR; A. 

TCHEREPANOV. SUNY Downstate Med. Ctr. 

2:00 H69 452.10 Persistent increases of PKMζ in the 

hippocampal CA1 region during spatial memory storage. 

C. HSIEH*; P. TSOKAS; P. A. SERRANO; T. C. SACKTOR. 

SUNY Downstate Med. Ctr., CUNY Hunter Col. 

3:00 H70 452.11 � Up-regulation of the catalytic subunit of 

PKA during the induction of long-lasting synaptic facilitation in 

Aplysia. A. MARINA*; X. YE; T. J. CAREW. Univ. of California, 

Irvine. 

4:00 I1 452.12 Role of α-actinin in modulating CaMKIIdependent 

regulation of NMDA receptors. N. JALAN- 

SAKRIKAR*; R. COLBRAN. Vanderbilt Univ. 



1:00 I2 452.13 • Inhibition of pyk2 signaling by striatalenriched 

tyrosine phosphatase (STEP). J. XU*; P. KURUP; J. 

A. BARTOS; J. W. HELL; P. J. LOMBROSO. Yale Univ. Sch. 

Med., Univ. of California, Davis. 

2:00 I3 452.14 Stochastic simulations of spatial specificity 

in synaptic plasticity. B. KIM*; K. T. BLACKWELL. Krasnow 

Inst. For Advanced Study. 

3:00 I4 452.15 Effects of chronic caffeine treatment 

on sleep deprivation-impaired late-ltp in area ca1. I. A. 

ALHAIDER*; T. TRAN; K. ALKADHI. Univ. Houston. 

4:00 I5 452.16 Probing the mechanisms regulating 

glutamate receptor trafficking with single quantum dot 

tracking. S. LABRECQUE*; P. OPAZO; D. CHOQUET; P. DE 

KONINCK. Ctr. De Recherche Univ. Laval Robert-Giffard, 

CNRS-UMR 5091 Univ. Bordeaux 2. 

1:00 I6 452.17 PKA location and striatal synaptic 

plasticity. R. C. EVANS*; K. T. BLACKWELL. George Mason 

Univ. 

2:00 I7 452.18 Targeting of neuronal CaMKII isoforms 

by densin requires a central CaMKII-binding domain with 

similarity to the CaMKII inhibitor protein, CaMKIIN. Y. JIAO; 

N. JALAN-SAKRIKAR; A. J. ROBISON; A. J. BAUCUM; R. J. 

COLBRAN*, Ph.D. Vanderbilt Univ. Sch. Med., Mount Sinai 

Sch. of Med. 

3:00 I8 452.19 Local crosstalk between PKA and MAPK 

signaling cascades at the SN-MN synapse during induction 

of intermediate-term synaptic facilitation in Aplysia. X. YE*; A. 

MARINA; T. J. CAREW. Univ. of California, Irvine. 

4:00 I9 452.20 Modeling classical conditioning with 

network motifs. J. KEIFER*; J. C. HOUK. Neurosci Grp, Univ. 

South Dakota Sch. Med., Northwestern Univ. Med. Sch. 

1:00 I10 452.21 Striatal enriched protein tyrosine 

phosphatase (STEP) mediates the beneficial effects of 

antipsychotic drugs. N. C. CARTY*; P. KURUP; J. XU; D. 

R. AUSTIN; G. CHEN; P. J. LOMBROSO. Yale Univ. Sch. 

of Med., Natl. Inst. of Mental Hlth. Div. of Intramural Res. 

Programs. 

2:00 I11 452.22 The role of an mRNA binding protein 

Translin (TBRBP) in hippocampal synaptic plasticity. A. J. 

PARK*; T. HUANG; T. ABEL. Univ. of Pennsylvania. 

3:00 I12 452.23 Phorbol ester enhances long-term 

potentiation of neurogranin knockout mice. F. L. HUANG; K. 

HUANG*. NICHD, NIH. 

4:00 I13 452.24 Synapse-to-nucleus signaling of the 

transcriptional coactivator TORC1 in hippocampal neurons. T. 

CH’NG*; P. LIN; B. UZGIL; K. C. MARTIN. UCLA. 

1:00 I14 452.25 Mutual regulation of Src family kinases 

and the neurotrophin receptor, TrkB. Y. Z. HUANG; J. O. 

MCNAMARA*. Duke Univ. Med. Ctr. 

2:00 I15 452.26 PKMzeta maintains object identity memory 

in perirhinal cortex. O. M. HARDT*; A. BOZZO; K. AUGERAU; 

P. V. MIGUES; K. NADER. McGill Univ. - Psychology. 

3:00 I16 452.27 Functional role of type VI adenylyl cyclase 

(AC6) in neuronal plasticity. C. CHANG*; J. LIN; C. WU; Y. 

CHERN. Academia Sinica. 



POSTER 

453. Synaptic Plasticity: Presynaptic Mechanisms 


Mechanisms 


1:00 I17 453.1 Bcl-XL determines the metabolic efficiency 

of synaptic transmission through interaction with mitochondrial 

ATP synthase. K. N. ALAVIAN*; H. LI; L. COLLIS; S. 

SACCHETTI; L. BONANNI; M. GRAHAM; C. RAHNER; M. A. 

MARIGGIO; E. MCNAY; P. SMITH; M. MARIE HARDWICK; E. 

A. JONAS. Yale Univ., Marine Biol. Lab., Univ. G.D’Annunzio 

of Chieti-Pescara, SUNY, Johns Hopkins Univ. 

2:00 I18 453.2 Attenuation of forskolin-induced mossy 

fiber long-term potentiation by zinc and its significance. M. 

ANDO*; A. TAKEDA; N. OKU. Univ. of Shizuoka. 

3:00 I19 453.3 Activation of presynaptic NPY type 5 

receptors triggers a sustained increase in GABA release from 

cerebellar stellate cells. C. J. DUBOIS; P. RAMAMOORTHY; 

M. D. WHIM; J. LIU*. LSU Hlth. Sci. Ctr., Penn State Univ. 

4:00 I20 453.4 VTA α7-nicotinic acetylcholine receptors 

mediate nicotinic modulation of glutamatergic synaptic 

plasticity in dopamine neurons. J. WU*; M. GAO; Y. JIN; K. 

YANG; R. J. LUKAS. Barrow Neurolog Inst., Barrow Neurolog. 

Inst. 

1:00 I21 453.5 LTP and LTD in rat auditory cortex induced 

by intracellular tetanization. C. M. LEE*; M. VOLGUSHEV. 

Univ. of Connecticut. 

2:00 I22 453.6 BCL-xL alters the kinetics of vesicle 

recycling at hippocampal synapses. H. LI*; P. ZHANG; K. 

ALAVIAN; C. RAHNER; J. HARDWICK; E. JONAS. Yale 

Univ., Johns Hopkins. 

3:00 I23 453.7 Modeling how the high frequency 

tetanus often used to induce long-term potentiation in CA1 

hippocampal pyramidal cells works. W. R. HOLMES*; L. M. 

GROVER. Ohio Univ., Marshall Univ. Sch. of Med. 

POSTER 

454. Oscillations and Synchrony: Modulation by Receptors 


Mechanisms 


1:00 I24 454.1 • GABAB modulation of emergent cortical 

rhythms: An experimental and computational study. M. V. 

SANCHEZ-VIVES; M. PEREZ-ZABALZA; J. MANRIQUE; R. 

REIG; M. WINOGRAD; N. PARGA*. ICREA-IDIBAPS, Univ. 

Autonoma Madrid. 

2:00 I25 454.2 The modulatory effect of dopamine 

receptor activation on hippocampal gamma oscillations and 

their underlying cellular mechanisms in rat hippocampal 

slices. R. H. ANDERSSON*; A. JOHNSTON; A. FISAHN. 

Karolinska Institute, Dept. of Neurosci. 

3:00 I26 454.3 Dopaminergic modulation of the inhibitory 

network oscillation in the rat basolateral amygdala. H. 

OHSHIRO*; T. MURAKOSHI. Grad. Sch. of Arts & Sciences, 

The Univ. of Tokyo, Saitama Med. Univ. 

4:00 I27 454.4 Midazolam alters the theta phase profile 

in the CA1 region of the hippocampus at ED50 for amnesia 

by modulating receptors containing alpha5 GABAR subunits. 

S. BALAKRISHNAN*; M. G. PERKINS; R. A. PEARCE. Univ. 

Wisconsin, Madison. 


Mon. PM

1:00 I28 454.5 The role of GABAergic inhibition in 

dynamics of theta oscillation in rat neocortex slices. Y. 

XIAO*; J. WU; S. V. WERT; X. HUANG; B. GLUCKMAN; S. 

J. SCHIFF*. Penn State Univ., Georgetown Univ. Med. Ctr., 

Duke Univ. Med. Ctr. 

2:00 I29 454.6 • Effects of chronic nicotine exposure 

on synaptic plasticity and neural network function in rat 

hippocampal slices. R. KIMURA*; K. ELLSWORTH; R. 

LUKAS; J. WU. Univ. of Alberta, Barrow Neurolog. Inst. 

3:00 I30 454.7 • Cholinergic modulation of pyramidal and 

fast spiking cell activity: Implications for gamma oscillations. 

D. E. PAFUNDO*; D. A. LEWIS; G. GONZALEZ-BURGOS. 


4:00 I31 454.8 Synthetic amyloid β-peptide increases 

spontaneous firing in glutamatergic neurons of the medial 

septum/diagonal band of Broca. R. N. LEÃO; L. BORGIUS; L. 

V. COLOM; O. KIEHN; A. FISAHN*. Karolinska Inst., Univ. of 

Texas. 

1:00 I32 454.9 Pharmacological modulation of bursting 

dynamics in cultured hippocampal networks. R. DZAKPASU*; 

M. NIEDRINGHAUS. Georgetown Univ. 

2:00 I33 454.10 NMDA receptor antagonist and 

developmental modulation of in vitro gamma oscillations in the 

mouse prelimbic cortex. J. M. MCNALLY*; Y. YANAGAWA; 

R. W. MCCARLEY; R. E. BROWN. VABHS, Harvard Med. 

Sch., Gunma Univ. Grad. Sch. of Med., Harvard Med. School, 

VABHS. 

3:00 I34 454.11 NMDA-dependent fast network oscillations 

in the prefrontal cortex in vitro. C. L. GILLOUGLEY*; V. 

GLYKOS; M. O. CUNNINGHAM; M. A. WHITTINGTON; F. E. 

N. LEBEAU. Inst. of Neurosci. 

4:00 I35 454.12 Entorhinal cortex-specific disruption 

of gamma frequency oscillations by NMDA receptor autoantibodies. 

A. LAWLEY; K. D. BERA; G. RENTESI; M. 

L. PIERCE*; M. A. WHITTINGTON; A. VINCENT; M. O. 

CUNNINGHAM. Newcastle Univ., Oxford Univ. 

1:00 I36 454.13 Spatio-temporal aspects of human 

temporal neocortical gamma oscillations in vitro. M. L. 

PIERCE; M. KRAMER; G. J. CLOWRY; A. B. TORT; 

J. CROSSMAN; A. JENKINS; C. NICHOLSON; I. S. 

SCHOFIELD; R. D. TRAUB; M. A. WHITTINGTON; M. O. 

CUNNINGHAM*. Newcastle Univ., Boston Univ., Edmond and 

Lily Safra Inst. of Neurosci., Newcastle Gen. Hosp., IBM T.J. 

Res. Ctr. 

2:00 I37 454.14 Entorhinal cortex-specific disruption of 

gamma frequency oscillations in cross-fostered rodents. S. 

HALL*; H. RANGEL-ESPER; N. GARCIA-CAIRASCO; C. 

RACCA; M. WHITTINGTON. ION, Ribeirao Preto Sch. of 

Med. 

3:00 I38 454.15 GluR5-containing kainate receptors drive 

persistent gamma frequency oscillations in the rat basolateral 

amygdala in vitro. F. E. RANDALL*; M. A. WHITTINGTON; G. 

W. ARBUTHNOTT; M. O. CUNNINGHAM. Okinawa Inst. of 

Sci. and Technol., Newcastle Univ. 


POSTER 

455. Alzheimer’s Disease: Abeta and Inflammation 



1:00 I39 455.1 Oligomer amyloid-β stimulates tyrosinekinase 

dependent microgliosis in Alzheimer’s disease. G. 

DHAWAN*; A. FLODEN; C. COMBS. Univ. North Dakota. 

2:00 I40 455.2 β-amyloid aggregates differentially affect 

neuronal viability and microglial function. D. FERRERA; C. 

CANALE; F. BENFENATI; L. GASPARINI*. Italian Inst. of 

Technol. 

3:00 J1 455.3 The natural history of astrocytic and 

microglial reactions in Alzheimer disease. A. SERRANO- 

POZO*; M. L. MIELKE; C. M. WILLIAM; J. H. GROWDON; T. 

GÓMEZ-ISLA; M. P. FROSCH; B. T. HYMAN. Massachusetts 

Gen. Hospital. MassGeneral Inst. For Neurodegenerative 

Dise. 

4:00 J2 455.4 The Alzheimer’s disease-associated 

β-amyloid (Aβ) protein is an antimicrobial peptide that 

employs a redox mechanism of action against pathogens. 

S. J. SOSCIA*; K. J. WASHICOSKY; S. M. TUCKER; D. R. 

MARENDA; A. J. SAUNDERS; R. E. TANZI; R. D. MOIR. 

Mass Gen. Hosp., Boston Univ. Sch. of Med., Drexel Univ., 


1:00 J3 455.5 Novel antimicroibal mechanism for Aβ, 

amylin, and other metal-binding amyloidogenic peptides. K. J. 

WASHICOSKY; S. J. SOCIA; S. M. TUCKER; R. E. TANZI; R. 

D. MOIR*. Massachusetts Gen. Hosp., Boston Univ. Sch. of 

Med., Harvard Med. Sch. 

2:00 J4 455.6 The prostaglandin EP2 receptor 

regulates the macrophage oxidative stress response. J. U. 

JOHANSSON*; S. PRADHAN; Q. WANG; K. ANDREASSON. 


3:00 J5 455.7 Differential effect of amyloid beta on 

epoxygenase activity in brain tissue ex vivo. P. SARKAR*; J. 

NARAYANAN; D. R. HARDER. Med. Col. of Wisconsin. 

4:00 J6 455.8 TNF-α mediates the neurotoxicity effects 

of Aβ 25-35 in the rat hippocampus. A. G. LOPEZ*; R. C. 

CUEVAS-MARTINEZ; G. VAZQUEZ-VICTORO. Lab. de 

Histopatología, ENP, UNAM., Inst. de Fisiología Celular, 

UNAM. 

1:00 J7 455.9 Monocytes and microglia are activated 

by different stages of amyloid-beta fibril formation. G. 

PARANJAPE*; D. AJIT; M. L. D. UDAN; M. R. NICHOLS. 

Univ. of Missouri-St Louis. 

2:00 J8 455.10 Role of Abeta oligomers and fibrils on 

cell adhesion and migration. Y. LIM*; J. WOO; S. KIM; D. E. 

KANG. Seoul Natl. Univ., Univ. of California. 

3:00 J9 455.11 Enhanced susceptibility or resistance to 

neurodegeneration / autoimmune disease in mice infected 

with coxsackievirus shortly after birth. S. M. ROBINSON*; F. 

LIU; C. RULLER; A. GOPAL; R. LACHARITE; S. CROCKER; 

E. MASLIAH; I. VERMA; J. WHITTON; R. FEUER. San Diego 

State Univ., Salk Inst., Univ. of Connecticut, Univ. of California 

at San Diego, The Scripps Res. Inst. 

4:00 J10 455.12 Time-dependant recovery from 

a neuroinflammation-induced spatial memory deficit 

corresponds with increased SNAP25 expression in the 

hippocampus. H. M. BROTHERS*; R. M. KAERCHER; M. R. 

MITCHEM; S. M. TURNER; Y. MARCHALANT; G. L. WENK. 

The Ohio State Univesity, NIH, Univ. de la Mediterranée. 



1:00 J11 455.13 In vitro and ex vivo comparative model 

of Aβ phagocytosis and degradation by MMP-9-mediated 

mechanism in microglia and peripheral macrophages. P. A. 

ARROYO ZÚÑIGA*; R. E. VON BERNHARDI. Pontificia Univ. 

Catolica De Chile. 

2:00 J12 455.14 Scavenger receptor class A as modulates 

of the inflammatory response of astrocytes. P. MURGAS*; B. 

GODOY; D. SOTO; R. E. VON BERNHARDI. Pontificia Univ. 

Católica De Chile. 

3:00 J13 455.15 Neuroprotective effect of astrocytes 

depends on the modulation of Aβ-induced microglial cell 

cytotoxicity are mediated by Interleukin 1β. B. M. SOLER*; G. 

RAMÍREZ; R. E. VON BERNHARDI. Pontificia Univ. Católica 

De Chile. 

4:00 J14 455.16 Complement receptors differentially affect 

Alzheimer’s disease amyloid pathology in mice. E. CZIRR*; T. 

FUKUHARA; R. NARASIMHAN; M. BRITSCHGI; T. WYSS- 

CORAY. Stanford Univ. 

POSTER 

456. APP Processing 



1:00 J15 456.1 • Trafficking and processing of APP in 

neurons. S. R. DEBOER*; S. S. SISODIA. Univ. of Chicago. 

2:00 J16 456.2 Intracellular cholesterol redistribution 

influences amyloid precursor protein processing in N2a cells. 

M. MAULIK*; S. KAR. Univ. of Alberta. 

3:00 J17 456.3 Study of the amyloid precursor protein 

processing in familial Alzheimer disease brains. M. PERA*; 

C. GUARDIA-LAGUARTA; N. SETÓ; M. RODRÍGUEZ; N. 

BADIOLA; M. SUÁREZ-CALVET; A. LLADÓ; I. FERRER; 

J. CLARIMON; A. LLEÓ. Inst. Investigacions Biomediques 

Sant Pau-Hospital De Sant Pau, Ctr. de Investigación 

Biomédica en Red sobre Enfermedades Neurodegenerativas, 

Alzheimer’s Dis. and Other Cognitive Disorders Unit, Dept. 

of Neurology, Hosp. Clínic, Neuropatologia, Servei Anatomia 

Patológica, IDIBELL-Hospital Universitario de Bellvitge, Univ. 

de Barcelona (UB). 

4:00 J18 456.4 Studies on the cellular trafficking and 

processing of amyloid precursor protein with a novel double 

fluorescently labeled APP. K. A. COOLEY*; X. HE; C. 

CHUNG; J. TANG. Oklahoma Med. Res. Fndn., Univ. of 

Oklahoma Hlth. Sci. Ctr. 

1:00 J19 456.5 Retromer disruption promotes 

amyloidogenic APP processing. C. P. SULLIVAN; A. JAY; J. M. 

WELLS*; P. J. MORIN. ENRM VA Hosp. 

2:00 J20 456.6 Homeodomain interacting protein kinase 

2 as a target of beta amyloid leads to altered p53 folding and 

functions. M. RACCHI*; L. NARDINOCCHI; R. PUCA; G. 

D’ORAZI; D. UBERTI; M. MEMO; S. STANGA; S. GOVONI; 

C. LANNI. Univ. Pavia, Dept of Exptl. and Applied Pharmacol., 

Natl. Cancer Inst. - Roma and Dept of Oncology and 

Neurosci. Univ. of Chieti, Univ. of Brescia. 

3:00 K1 456.7 Statins strongly increase APPneo, 

the intracellular caspase cleavage of APP in vitro. O. 

DESCAMPS; V. JOHN; D. E. BREDESEN*. Buck Inst. for Age 

Res. 

4:00 K2 456.8 Exogenous Aβ modulates APP processing 

through Tau kinase mediated pathways. T. REVETT*; D. 

WESTAWAY; S. KAR. Univ. of Alberta. 



1:00 K3 456.9 Rapamycin promotes beta-amyloid 

production by inhibition of ADAM-10 activation. S. ZHANG; 

B. GIUNTA; D. OBREGON; Y. ZHU; T. MORI; J. TAN*. Univ. 

of South Florida, Neuroimmunology Laboratory, Silver Child 

Develop. Center,, Saitama Med. Center/University, James A. 

Haley Veterans’ Hosp. 

2:00 K4 456.10 • Tienma modulates the proteolytic 

processing of the amyloid precursor protein - A perspective to 

treat Alzheimer’s disease. K. HEESE*; M. MISHRA. Nanyang 

Technological Univ. 

3:00 K5 456.11 Investigating the role of protein 

phosphatases in regulating APP metabolism. S. UTREJA*; A. 

SAUNDERS. Drexel Univ. (dept of Biology). 

4:00 K6 456.12 Modulation of hippocampal muscarinic 

receptors influences APP processing - An in vivo microdialysis 

study. T. WELT; J. MCAFOOSE; L. KULIC; S. HOEY; C. 

HOCK*; A. FISHER; R. N. NITSCH. Univ. Zuerich, Israel Inst. 

for Biol. Res. 

1:00 K7 456.13 Ubiquilin-1 is a potent regulator of APP 

trafficking, processing and degradation; role of ubiquitination. 

A. EL AYADI*; E. S. STIEREN; J. M. BARRAL; D. 

BOEHNING. Neurosci. and Cell Biol., Univ. of Texas Med. Br. 

2:00 K8 456.14 Stimulation of amyloid-β production by 

altering amyloid precursor protein trafficking. C. H. CHUNG*; 

K. COOLEY; X. HE; J. TANG. Oklahoma Med. Res. Fndn., 

The Univ. of Oklahoma Hlth. Sci. Ctr. 

3:00 K9 456.15 Does VEGF play a role in processing of 

amyloid precursor protein in the neuro-glia-vascular unit? 

R. SCHLIEBS*; S. BÜRGER; K. GÜNTER; M. BIGL; L. 

KIRAZOV; E. KIRAZOV; E. KOUZNETSOVA; Y. YAFAI. Paul 

Flechsig Inst. Brain Res., Inst. of Biochemistry, Univ. Leipzig, 

Inst. Exp. Morphology and Anthropology, Bulgarian Acad., 

Dept Eye Clinics, Univ. Hospital, Univ. Leipzig. 

4:00 K10 456.16 Beta-secretase cleavage site mutant 

amyloid precursor protein alters axonal transport and 

morphology. E. M. RODRIGUES*; L. S. B. GOLDSTEIN. 

UCSD. 

1:00 K11 456.17 • Reduction of hippocampal amyloid beta 

1-40 and 1-42 following administration of an M1-selective 

muscarinic agonist in a mouse model of Alzheimer’s disease. 

M. L. HENDRICKSON*; M. L. VERDONE; J. G. FARNHAM; 

R. R. COPP; T. M. TWOSE. Mithridion, Inc. 

2:00 K12 456.18 Genetic dissection of the amyloid 

precursor protein in developmental functions and amyloid 

pathogenesis. H. LI*; B. WANG; Z. WANG; Q. GUO; K. 

TABUCHI; R. E. HAMMER; T. C. SUDHOF; H. ZHENG*. 

Baylor Col. of Med., UT Southwestern Med. Ctr., Natl. Inst. for 

Physiological Sci., Stanford Univ. 

POSTER 

457. Alzheimer’s Disease: APP, APP/PS1 Animal Models 



1:00 K13 457.1 Impaired spatial learning and increased 

locomotor activity in TgCRND8 mice, a murine model of 

Alzheimer’s disease. J. M. WALKER; S. L. WADE; A. K. 

RAMSEY; D. K. MILLER; G. Y. SUN; A. SIMONYI*; T. R. 

SCHACHTMAN. Univ. Missouri. 


Mon. PM

2:00 K14 457.2 Low beta-amyloid pathology in apoptosis 

factor-deficient mice. L. KULIC*; S. CATTEPOEL; T. WELT; M. 

WOLLMER; C. HOCK; R. M. NITSCH. Univ. of Zurich, Div. of 

Psychiatry Res., Psychiatric Univ. Clin. Basel. 

3:00 K15 457.3 Aggression in males in transgenic APP 

mouse models of Alzheimer’s disease. C. G. JANUS*; A. 

OLIVEROS; J. HOWARD; L. YOUNKIN; D. BORCHELT; S. 

YOUNKIN. Univ. of Florida, Mayo Clin. 

4:00 K16 457.4 Lithium improves hippocampal 

neurogenesis, neuropathology and cognitive functions in APP 

mutant mice. M. C. ROSI; A. FIORENTINI; C. GROSSI; F. 

CASAMENTI*. Univ., Univ. Florence. 

1:00 K17 457.5 Studies on the NGF metabolism in a new 

transgenic rat model of Alzheimer’s disease-like amyloid 

pathology and in Down’s syndrome cortical neurons. M. 

F. IULITA*; W. C. LEON; T. MELIS; J. BUSCIGLIO; A. C. 

CUELLO. McGill Univ., Univ. of California. 

2:00 K18 457.6 CX3CR1 deficiency alters microglial 

activation and reduces beta-amyloid deposition in two 

Alzheimer’s disease mouse models. S. LEE*; N. H. VARVEL; 

M. E. KONERTH; A. E. CARDONA; R. M. RANSOHOFF; B. T. 

LAMB. Lerner Res. Inst. 

3:00 K19 457.7 Energetic dyshomeostasis in APP- 

Transgenic TgCRND8 mice. B. M. FRANCIS*; V. LASKOVA; 

J. YANG; C. SONG; R. P. BAZINET; S. GUPTA; M. MAJ; B. 

H. ROBINSON; H. T. J. MOUNT. Univ. Toronto, Ctr. for Res. 

in Neurodegenerative Dis., Univ. Toronto, Hosp. for Sick 

Children. 

4:00 K20 457.8 • IntelliCage behavior and relationship with 

brain pathology in the Tg2576 mouse model. A. CODITA; 

S. SOLE DOMENECH; E. BENEDIKZ; B. WINBLAD; A. H. 

MOHAMMED*. Karolinska Institutet. 

1:00 L1 457.9 Failed paired-pulse inhibition of multiple 

population spikes in hippocampal slices of APP/PS1 

transgenic mice. K. GUREVICIUS*; I. GUREVICIENE; H. 

TANILA. A. I. Virtanen Institute, Univ. of Eastern Finland. 

2:00 L2 457.10 The effect of age on metal deposition in 

amyloid beta plaques in Tg2576 mice, a murine model of 

Alzheimer’s disease. E. S. GIDEONS*; C. M. GROEBER; 

R. SMITH; K. M. CONKO; J. M. FLINN; A. RAILEY. George 

Mason Univ., Brookhaven Natl. Lab., United States Geological 

Survey. 

3:00 L3 457.11 Prenatal maternal stress sex-dependently 

alters memory and affect in the APPswe/PS1dE9 mouse 

model of Alzheimer’s disease. A. S. R. SIERKSMA*; J. 

PRICKAERTS; L. DELBROEK; L. CHOULIARAS; K. 

RUTTEN; H. W. M. STEINBUSCH; D. L. A. VAN DEN HOVE. 

Maastricht Univ. 

4:00 L4 457.12 • The effect of amyloid beta plaques on 

visual ability, learning and memory in the APPswe/PS1dE9 

mouse model of Alzheimer’s disease. K. STOVER*; R. E. 

BROWN. Dalhousie Univ. 

1:00 L5 457.13 A novel transgenic mouse model studying 

the effects of corticotropin-releasing factor on cognitive 

function and amyloid pathogenesis. K. M. MURPHY; L. 

MENG; B. J. KOLBER; L. J. MUGLIA; J. G. CSERNANSKY*; 

H. DONG. Northwestern Univ., Washington Univ., Vanderbilt 


2:00 L6 457.14 Corticotropin-releasing factor receptor 

antagonists regulate amyloid-β levels in Tg2576 mice. L. 

MENG; K. M. MURPHY; J. G. CSERNANSKY; H. DONG*. 

Northwestern Univ. Feinberg Sch. of Med. 


3:00 L7 457.15 Elucidating the source of calcium 

dyshomeostasis in Alzheimer’s disease. J. R. BOIVIN*; 

M. ARBEL-ORNATH; A. M. BELCHER; B. J. BACSKAI. 


4:00 L8 457.16 Impairment of angiogenesis in the brains 

of transgenic mouse models of Alzheimer’s disease. N. 

GANEY*; V. LAPORTE; C. BACHMEIER; D. BEAULIEU- 

ABDELAHAD; M. BANASIAK; S. MURPHY; S. BREM; N. 

PATEL; V. MATHURA; M. MULLAN; D. PARIS. Roskamp 

Inst., Moffitt Cancer Ctr. 

1:00 L9 457.17 Morphometric analysis of inner retinal 

layer in a mouse model of Alzheimer’s disease. K. CHIU*; I. 

Y. P. LEUNG; J. C. H. LUI; C. K. M. LOK; Y. S. HO; L. BAUM; 

K. F. SO; R. C. C. CHANG. The Univ. of Hong Kong, Univ. of 

Calgary, The Chinese Univ. of Hong Kong. 

2:00 L10 457.18 The overexpression of CPG15 attenuates 

the deficits in cognitive functions in Alzheimer’s disease 

animal models. J. RYU*; Y. CHOI; M. KIM; H. CHO; Y. SUH; J. 

KIM; H. KIM. Col. of Medicine, Seoul Natl. Univ., POSTECH, 

Seoul Natl. Univ. Bundang Hospital, Seoul Natl. Univ. Col. of 

Med. 

3:00 L11 457.19 Stress axis perturbations and decreased 

cognitive performance precede amyloid plaque deposition 

in an Alzheimer’s Disease knock-in mouse model. N. J. 

JUSTICE*; Q. GUO; H. ZHENG. Baylor Col. of Med. 

4:00 L12 457.20 The effects of MyD88 deficiency and 

APPswe/PS1dE9 overexpression on exploratory activity, 

anxiety, motor coordination and spatial learning in mice. J. 

LIM*; J. KOU; J. JIN; A. PATTANAYAK; R. LALONDE; K. 

FUKUCHI. Univ. of IL Coll of Med. At Peoria, Univ. de Rouen. 

1:00 M1 457.21 Nicotine prevents and stress intensifies 

impairment of late phase LTP in beta-amyloid rat model of 

Alzheimer’s disease. A. DAO*; M. SRIVAREERAT; T. T. TRAN; 

K. H. ALZOUBI; K. A. ALKADHI. Univ. of Houston, Jordan 

Univ. of Sci. and Technol. 

2:00 M2 457.22 Impaired cerebrovascular functions in the 

arcAbeta mouse model of Alzheimer’s disease. M. MERLINI; 

E. P. MEYER; A. ULMANN-SCHULER; M. WYSS; B. 

WEBER; R. M. NITSCH*. Univ. Zurich, Univ. Hosp. Zurich. 

3:00 M3 457.23 Insulin deficiency promotes Alzheimer’s 

disease. A. KNEYNSBERG; A. KUMAR; G. PERRY; I. 

KADISHA; T. VAN GROEN; R. JOPE; E. ROBERSON; M. J. 

LESORT*. Univ. of Alabama, Birmingham. 

4:00 M4 457.24 The Role of iNOS on induced inflammation 

and Alzheimer’s disease pathology. S. K. SCHROEDER*; 

D. E. WILLIAMS, III; D. C. LEE; M. N. GORDON; D. G. 

MORGAN. Univ. of South Florida, Tampa. 

1:00 M5 457.25 Alzheimer genes change the generation 

of SVZ neurons in AD model mice. T. VAN GROEN*; J. 

ECHOLS; P. MIETTINEN; I. KADISH. Univ. Alabama- 

Birmingham, Univ. of Alabama at Birmingham, Univ. of 

Kuopio. 

2:00 M6 457.26 Comprehensive behavioral assays for 

assessing cognitive deficits in Thy1-APPLond/swe transgenic 

mouse model of Alzheimer’s disease. N. L. SAW*; M. FAIZI; 

T. NGUYEN; S. BERAKI; T. WYSS-CORAY; F. LONGO; M. 

SHAMLOO. SINTN, Stanford Univ. Sch. of Med. 

3:00 M7 457.27 Traumatic brain injury induces neuronal 

cell cycle abnormalities in a mouse model of Alzheimer’s 

disease. O. KOKIKO-COCHRAN*; Y. LEE; B. LAMB. Lerner 

Res. Inst. Cleveland Clin. 



4:00 M8 457.28 Early pathology in entorhinal cortex and 

dentate gyrus accompanied by a behavioral impairment 

in a mouse model of Alzheimer’s disease pathology. N. S. 

BURGHARDT*; K. BERMUDEZ-HERNANDEZ; A. POVEDA; 

M. SCHANER; A. DUFFY; P. MATHEWS; J. LAFRANCOIS; 

S. KARANTZOULIS; S. DE SANTI; C. MYERS; S. FERRIS; 

H. SCHARFMAN. Columbia Univ., New York Univ. Langone 

Med. Ctr., The Nathan Kline Inst., Veterans Affairs Med. Ctr. 

1:00 M9 457.29 Learning deficits and neurogenesis in 

transgenic mice that overproduce A-beta. J. FRACKOWIAK*; 

B. RANASINGHE; G. LAFAUCI; R. RUBENSTEIN; A. 

LYSENKO; R. KOLECKI; W. KACZMARSKI; B. MAZUR- 

KOLECKA,. NYS Inst. For Basic Res. In Developmental 

Disabilities, Col. of Staten Island, NYS Inst. for Basic Res. 

in Developmental Disabilities, SUNY Downstate Med. Ctr., 

Wagner Col., Lehigh Univ. 

2:00 M10 457.30 • Pyroglutamate-modified amyloid beta 

peptide in APPSwe/PS1 (P264L) mouse and Alzheimer’s 

brain. G. WU; R. MILLER; J. MARCUS; P. SZCZERBA; L. 

GOLD; J. RENGER; M. J. SAVAGE*. Merck & Co. 

POSTER 

458. Metabolism and Toxicity of Alpha-Synuclein III 



1:00 M11 458.1 • PD1711-mediated suppression of 

a-Synuclein toxicity in a model for Parkinson’s Disease. Y. T. 

CHEN*; T. TULLY. Dart Neurosci., SUNY Stony Brook, Dart 

Neurosciecne LLC. 

2:00 M12 458.2 � Axonal transport and presynaptic 

targeting deficits of α-synuclein in pathologic states. Y. TANG; 

D. SCOTT; S. ROY*. Univ. of California, San Diego. 

3:00 M13 458.3 Synergistic effects of tau and alphasynuclein 

in dopaminergic neurons. B. ROY; S. S. 

AMBEGAOKAR; G. R. JACKSON*. Univ. Texas Med. Br. 

4:00 M14 458.4 Dietary Docosahexaenoic acid, an 

omega-3 fatty acid, controls the levels of α-Synuclein 

pathology in brains of mice transgenic for the A53T mutant 

form. R. SHARON*; E. YAKUNIN; V. LOEB; H. KISOS. 

Hebrew Univ-Hadassah Sch. 

1:00 M15 458.5 Overexpression of alpha-synuclein 

in midbrain dopaminergic neurons cause alterations in 

dopamine neurotransmission in vivo preceding behavioral 

deficits and cell death. M. LUNDBLAD*; M. DECRESSAC; 

B. MATTSSON; M. CARTA; A. BJÖRKLUND. Exptl. Med. 

Science, Neurobiology, Lund Univ. 

2:00 M16 458.6 Okadaic acid stimulates the formation 

of α-synuclein aggregates through calcium- and 

transglutaminase-associated signaling pathway. Y. OH; E. IM; 

H. RHIM; Y. KIM; K. C. CHUNG*. Yonsei Univ., KIST, FCB- 

Pharmicell. 

3:00 M17 458.7 • Evaluation of the role of Polo-like kinases 

in α-synuclein phosphorylation in vivo. M. BERGERON*; R. 

MOTTER; F. SAN PABLO; P. TANAKA; D. KHOLODENKO; 

D. FAUSS; E. GOLDBACH; H. ZHANG; H. L. SHAM; J. P. 

ANDERSON. Elan Pharmaceuticals. 

4:00 M18 458.8 In vivo modulation of the autophagylysosomal 

pathway influences aggregation and toxicity of 

alpha-synuclein. J. KLUCKEN*; A. PÖHLER; P. J. MCLEAN; 

B. T. HYMAN; E. MASLIAH; J. WINKLER. Univ. Hosp. 

Erlangen, MGH, UCSD. 



1:00 N1 458.9 Synuclein accumulation after axotomy 

is a risk factor for neuronal cell death. D. J. BUSCH*; J. R. 

MORGAN. Univ. of Texas at Austin, Inst. for Cell. and Mol. 

Biol., Inst. for Neurosci. 

2:00 N2 458.10 • Molecular tweezers are broad-spectrum 

protein aggregation inhibitors showing promise for Parkinson’s 

disease therapy. G. BITAN*; S. SINHA; D. H. LOPES; A. 

ATTAR; K. MCDANIEL; R. BAKSHI; S. PRABHUDESAI; J. 

BRONSTEIN; F. RICHTER; C. ZHU; M. CHESSELET; T. 

SCHRADER; F. KLÄRNER. UCLA, Univ. of Duisburg-Essen. 

3:00 N3 458.11 Intrastriatal fetal dopaminergic grafts 

uptake and retrogradely transport virally expressed alpha 

synuclein from the host. H. B. DODIYA*; T. J. COLLIER; J. H. 

KORDOWER. Rush Univ. Med. Ctr., Univ. of Cincinnati. 

4:00 N4 458.12 Characterization of zebrafish synucleins. 

C. MILANESE*; Q. BAI; E. A. BURTON. Univ. of Pittsburgh, 

Fondazione RiMED. 

1:00 N5 458.13 Characterization of synuclein-directed 

proinflammatory events. D. A. JOSEPH*; T. R. MHYRE; 

A. MITTEREDER; B. A. BLOOM; K. M. NEITZKE; K. A. 

MAGUIRE-ZEISS. Georgetown Univ., Univ. of Virginia. 

2:00 N6 458.14 C-terminal truncated alpha-synuclein 

enhances the full-length alpha synuclein pathology in the rat 

nigrostriatal projection neurons. A. ULUSOY*; F. FEBBRARO; 

P. JENSEN; D. KIRIK; M. ROMERO-RAMOS. Lund Univ., 

Univ. of Aarhus. 

3:00 N7 458.15 Identification of cellular signaling 

pathways involved in α-synuclein-dependent cytotoxicity. C. L. 

KRAGH*; L. VESTERAGER; C. RICHTER-LANDSBERG; M. 

MANIECKI; P. H. JENSEN. Univ. Aarhus, Lundbeck A/S, Dept. 

of Biol., Dept. of Clin. Biochem. 

4:00 N8 458.16 Glycolipid-α-synuclein interactions 

contribute to vulnerability of striatal dopaminergic terminals. 

V. P. CHOU; M. Z. ISLA; J. LANGSTON; R. J. REIMER; A. B. 

MANNING-BOG*. SRI Intl., The Parkinson’s Inst., Stanford 

Univ. 

1:00 N9 458.17 Studies on the mechanism of rotenoneinduced 

activation of phagocytes NADPH oxidase. H. ZHOU*; 

H. GAO; Q. WANG; F. ZHANG; S. CHEN; D. ZHANG; J. 

HONG. NIEHS. 

2:00 N10 458.18 Characterization of inhibitory effect 

of naloxone on NADPH oxidase activity: Evidence for a 

direct interaction of naloxone with the gp91-p22 membrane 

component. Q. WANG*; B. LIU; H. ZHOU; J. HONG. NIEHS. 

3:00 N11 458.19 Alpha-synuclein dysfunction and 

neuroinflammation potentiates each other driving chronic 

progression of Parkinson’s disease. H. GAO*; F. ZHANG; H. 

ZHOU; B. C. WILSON; J. HONG. NIEHS/NIH. 

4:00 N12 458.20 • Reduced inflammation via PP2A 

modulation in alpha-synuclein transgenic mice. K. LEE; J. 

R. FERNANDEZ*; W. CHEN; X. FENG; E. JUNN; J. IM; 

E. MASLIAH; M. VORONKOV; S. P. BRAITHWAITE; J. B. 

STOCK; M. M. MOURADIAN. UMDNJ-Robert Wood Johnson 

Med. Sch., Signum Biosciences, Inc., Princeton Univ., Univ. of 

california - San Diego. 

1:00 N13 458.21 • SIG1012 ameliorates pathology in a 

model of Parkinson’s disease by modulating PP2A activity. 

M. M. MOURADIAN*; K. LEE; W. CHEN; E. JUNN; P. K. 

SONSALLA; H. GROSSO; X. FENG; J. R. FERNANDEZ; M. 

VORONKOV; S. P. BRAITHWAITE; J. B. STOCK. UMDNJ- 

Robert Wood Johnson Med. Sch., Princeton Univ., Signum 

Biosci. 


Mon. PM

2:00 N14 458.22 • Isolation of a component of coffee that 

modulates PP2A activity. M. VORONKOV*; Y. CHAO; X. 

FENG; J. R. FERNANDEZ; M. STOCK; J. B. STOCK; S. P. 

BRAITHWAITE. Signum Biosciences, Inc. 

POSTER 

459. Deep Brain Stimulation 



1:00 N15 459.1 Resveratrol reduces cell injury caused by 

surgery mimicking deep brain stimulation. G. TORRES*; B. H. 

HALLAS; J. R. LEHESTE; J. BECKER; K. CASTILLO; G. S. 

FRALEY. NYCOM/NYIT, Hope Col. 

2:00 N16 459.2 Multi-parametric analysis assists in STN 

localization in Parkinson’s disease. A. W. PRZYBYSZEWSKI; 

J. PILITSIS; L. D. MARGOLIN*; A. BARBORICA; P. RAVIN; P. 

NOVAK. Univ. of Massachusetts Med. Ctr., FHC, Inc. 

3:00 N17 459.3 Algorithm sensitivity in analysis of 

experimental data and network models of deep brain 

stimulation. P. J. HAHN*; C. C. MCINTYRE. Cleveland Clin. 

Lerner Resch Inst. 

4:00 N18 459.4 Deep brain stimulation reduces regional 

cerebral blood flow. Y. KUTTNER*; M. WEINBERGER; S. 

HASSIN-BAER; O. S. COHEN; T. S. ZWAS; E. GOSHEN; R. 

SPIEGELMANN; A. BIEGON. Sheba Med. Ctr., Bar-Ilan Univ., 

Tel Aviv Univ., Brookhaven Natl. Lab. 

1:00 O1 459.5 Abnormal posture in patients with 

Parkinson’s disease and deep brain stimulation. F. 

YOKOCHI*; M. TANIGUCHI. Tokyo Metro Neurolog Hosp. 

2:00 O2 459.6 • NMDA receptor-mediated plasticity in the 

alleviating after-effect of subthalamic stimulation on akinetic 

motor deficit in rat models of Parkinson’s disease. H. AKITA*; 

Y. HONDA; M. OGATA; K. NODA; M. SAJI. Dept Physiol Sch. 

Allied Helth Sci, Kitasato Univ., Div. of Brain Sciences, Grad. 

Sch. of Med. Sciences, Kitasato Univ. 

3:00 O3 459.7 A model of the closed loop basal gangliathalamocortical 

network for Parkinson’s disease and deep 

brain stimulation. G. KANG*; M. M. LOWERY. Univ. Col. 

Dublin. 

4:00 O4 459.8 Neurophysiological changes in the motor 

thalamus are related to severity of the parkinsonian state in 

the non-human primate model of parkinsonism. J. L. VITEK*; 

A. L. JENSEN; K. B. BAKER. Univ. of Minnesota. 

1:00 O5 459.9 Inhibition-excitation competition 

underlies beneficial effects of subthalamic nucleus deep 

brain stimulation. B. DEGOS; C. BOSCH; J. DENIAU; L. 

VENANCE*. INSERM U-667, Col. de France. 

2:00 O6 459.10 Subthalamic nucleus stimulation of 

healthy rats with patterns derived from neural recordings of 

parkinsonian rats. G. C. MCCONNELL*; J. D. HILLIARD; R. Y. 

QI; J. CHANG; W. M. GRILL. Duke Univ., Neurosci. Res. Inst. 

of North Carolina. 

3:00 O7 459.11 Subthalamic responses to motor cortex 

stimulation: Selective targeting of the subthalamic motor area. 

M. JANSSEN*; D. ZWARTJES; Y. TEMEL; V. VAN KRANEN- 

MASTENBROEK; P. MAGILL; P. VELTINK; T. HEIDA; V. 

VISSER-VANDEWALLE. Maastricht Univ., Maastricht Univ. 

Med. Ctr., Maastricht Inst. for Neuromodulative Develop. 

(MIND), European Grad. Sch. of Neurosci. (EURON), Twente 

Univ., Univ. of Oxford. 


4:00 O8 459.12 Encoding of sensorimotor information 

during deep brain stimulation. M. D. JOHNSON*; W. XU; J. 

ZHANG; J. L. VITEK. Univ. of Minnesota, Cleveland Clin. 

1:00 O9 459.13 • Evidence-based medicine in 

neuromodulation. C. R. BUTSON*; S. W. HUNG; J. A. 

BOBHOLZ; K. BLINDAUER; B. C. HINER; B. H. KOPELL; S. 

JAIN; C. J. SHERIDAN; V. CONTE; K. DRIESSLEIN. Med. 

Col. of Wisconsin. 

2:00 O10 459.14 Synchronized beta oscillations across 

pallidal nuclei strengthen in the moderately parkinsonian nonhuman 

primate. A. L. JENSEN*; K. B. BAKER; J. L. VITEK. 

Univ. of Minnesota. 

3:00 O11 459.15 Effects of STN DBS contact location 

on verbal fluency. P. LINTZENICH; M. C. CAMPBELL; H. 

LUGAR; S. D. TABBAL; M. KARIMI; T. O. VIDEEN; J. S. 

PERLMUTTER; T. G. HERSHEY*. Washington Univ. Sch. 

Med. 

4:00 O12 459.16 Computational model of local field 

potential recordings in the subthalamic nucleus. S. F. 

LEMPKA*; C. C. MCINTYRE. Cleveland Clin. 

1:00 O13 459.17 Dual role of inhibition in unleashing and 

quenching oscillatory activity in the dopamine-depleted 

basal ganglia. A. KUMAR*; A. AERTSEN; S. ROTTER; S. 

CARDANOBILE. Albert-Ludwig Univ. Freiburg, Bernstein Ctr. 

Freiburg. 

2:00 O14 459.18 High-frequency stimulation of the 

subthalamic nucleus inhibits the firing of juxtacellular labelled 

5-HT-containing neurons and decreases 5-HT release in 

vivo. S. TAN*; H. HARTUNG; V. VISSER-VANDEWALLE; 

H. STEINBUSCH; Y. TEMEL; T. SHARP. Maastricht Univ., 

Maastricht Univ. Med. Ctr., European Grad. Sch. of Neurosci. 

(EURON), Maastricht Inst. for Neuromodulative Develop. 

(MIND), Univ. of Oxford. 

3:00 O15 459.19 Human wireless fast-scan cyclic 

voltammetry during deep brain stimulation neurosurgery ii: 

Resolving neurotransmitters by the detrending algorithm 

and principle component regression analysis. D. JANG*; S. 

CHANG; R. SHAH; K. BENNET; S. GOERSS; C. J. KIMBLE; 

J. VAN GOMPEL; I. KIM; M. P. MARSH; P. A. GARRIS; Z. 

CHO; C. BLAHA; K. H. LEE. Mayo Clin., Neurosci. Reserach 

Inst., Illinois State Univ., Univ. of Memphis. 

4:00 O16 459.20 Effects of DBS contact location on acute 

mood response to STN DBS in Parkinson disease. M. C. 

CAMPBELL*; P. LINTZENICH; H. LUGAR; T. O. VIDEEN; K. 

J. BLACK; T. HERSHEY; J. S. PERLMUTTER. Washington 

Univ. 

1:00 O17 459.21 Time course of “lingering” stn dbs effects. 

S. E. COOPER*; A. M. NOECKER; J. L. VITEK; C. C. 

MCINTYRE. Cleveland Clin. Fndn. 

2:00 O18 459.22 Human wireless fast-scan cyclic 

voltammetry during deep brain stimulation neurosurgery I: 

Safety and feasibility study. S. CHANG*; K. BENNET; S. J. 

GOERSS; C. J. KIMBLE; J. VAN GOMPEL; I. KIM; M. P. 

MICHAEL; D. M. JOHNSON; K. KRESSIN; S. WHITLOCK; 

A. HORNE; P. MOHSENI; C. D. BLAHA; P. A. GARRIS; K. 

H. LEE. Mayo Clin., Case Western Reserve Univ., Univ. of 

Memphis, Illinois State Univ. 

3:00 P1 459.23 Upper extremity motor function 

assessment for non-human primates, a novel modification 

of the Klüver board task and computer-assisted analysis of 

movement kinematics. A. K. THOTA*; W. XU; J. R. HIRSCH; 

Z. I. WANG; J. ZHANG; J. L. VITEK; J. L. ALBERTS. Case 

Western Reserve Univ., Cleveland Clin., L Stokes Cleveland 

VA Med. Ctr. 



4:00 P2 459.24 • Improving postural stability in advanced 

Parkinson’s disease patients using a computational modeling 

approach to deep brain stimulation programming. A. M. M. 

FRANKEMOLLE; S. RICHARDSON; A. M. NOECKER; G. 

VARGA; C. C. MCINTYRE; J. L. ALBERTS*. Cleveland Clin., 

L. Stokes Cleveland VA Med. Ctr. 

1:00 P3 459.25 Neurotransplantation and deep brain 

stimulation for Parkinson’s disease: Long-term efficacy. S. 

YAKOV*; N. FEDOROVA; V. SHABALOV; V. SHTOK. Russian 

Med. Acad. of Postgraduate Educ., Russian Acad. of Med. 

Sciences, the Burdenko N.N. Neurosurg. Res. Inst. 

2:00 P4 459.26 Output assessment of medtronic external 

neurostimulator (ens) for intra-operative testing of therapeutic 

efficacy and adverse events during deep brain stimulation 

(dbs). E. L. HARGREAVES*; S. WONG; D. N. PETROV; C. 

PAVLIDES; S. F. DANISH. Robert Wood Johnson Med. Sch., 


POSTER 

460. Parkinson’s Disease: Neuroprotective Strategies 



1:00 P5 460.1 The effects of exercise on the brain 

transcriptome. A. C. MITCHELL*; R. LEAK; K. GARBETT; 

W. T. GREENOUGH; M. ZIGMOND; J. L. CAMERON; K. 

MIRNICS. Vanderbilt, Univ. of Pittsburgh, Vanderbilt Univ., 

Univ. of Illinois, Urbana-Champaign. 

2:00 P6 460.2 Over expression of vmat-2 and DTdiaphorase 

protec susbtantia nigra-derived cells against 

aminochrome neurotoxicity. P. MUÑOZ*; J. LOZANO; P. 

CAVIEDES; J. SEGURA-AGUILAR. Univ. of Chile, Fac. of 

Med. 

3:00 P7 460.3 Peroxisome proliferator-activated receptorgamma 

agonist pioglitazone modulated the neuroprotective 

properties of astrocytoma (astrocyes-like) cell in vitro. Y. 

WONG; A. R. JAISWAL; V. V. DUKHANDE; A. BHUSHAN; S. 

W. LEUNG; J. C. LAI*. Idaho State Univ., Univ. of Kentucky. 

4:00 P8 460.4 • � The intramuscular administration of 

the C-terminal fragment of tetanus toxin improves the fine 

motor skills and protects dopaminergic neurons from death 

in hemi-Parkinsonian rats. B. VENEGAS MENESES*; L. 

MENDIETA; I. MARTÍNEZ; J. MORÁN; M. HERRANDO; 

J. AGUILERA; E. GARCÍA; I. LIMÓN. Benemerita Univ. 

Autónoma De Puebla, Sci. Inst. BUAP, Univ. Autonoma de 

Barcelona, Inst. Nacional de Neurología y Neurocirugía 

“Manuel Velasco Suarez”. 

1:00 P9 460.5 The selective metabotropic glutamate 

receptor 5 antagonist MTEP prevents the loss of 

noradrenergic neurons in MPTP-treated monkeys. G. M. 

JEYARAJ*; D. ALAGILLE; S. JENKINS; G. TAMAGNAN; T. 

WICHMANN; Y. SMITH. Emory Univ., Mol. NeuroImaging, 

L.L.C. 

2:00 P10 460.6 Chronic antidepressant treatment and the 

nigrostriatal system: The impact of antidepressant-mediated 

neuroplasticity. K. L. PAUMIER*; A. J. SIDEROWF; C. E. 

SORTWELL; B. T. TERPSTRA; P. AUINGER; D. OAKES; 

L. MADHAVAN; N. D. LEVINE; K. STEECE-COLLIER; A. 

J. ESPAY; F. J. REVILLA; A. SAHAY; T. J. COLLIER. Univ. 

Cincinnati, Univ. of Pennsylvania, Michigan State Univ., Univ. 

of Rochester Rochester, New York, The Neurosci. Inst. 



3:00 P11 460.7 The tetanus toxin H C fragment promotes 

neuroprotection of striatum via activation of tyrosine kinase 

receptor signaling pathway in rat with 6-hydroxydopamine. 

L. MARTINEZ MENDIETA*; V. PALAFOX; A. SANCHEZ; I. 

MARTÍNEZ; M. HERRANDO; J. AGUILERA; R. MARTÍNEZ; 

I. D. LIMÓN. Benemérita Univ. Autónoma De Puebla, 

Benemérita Univ. Autónoma de Puebla, Univ. Autónoma de 

Barcelona. 

4:00 P12 460.8 Beneficial effects of cystamine following 

MPTP-induced parkinsonism in rodents. C. GIBRAT*; M. 

SAINT-PIERRE; C. ROUILLARD; F. CICCHETTI. Ctr. De 

Recherche Du CHUL (CHUQ), Univ. Laval. 

1:00 P13 460.9 Selective activation of the mGlu4 but not 

mGlu7 group III metabotropic glutamate receptor provides 

functional neuroprotection in the rat 6-OHDA model of 

Parkinson’s disease. M. BETTS*; M. O’NEILL; S. MITCHELL; 

S. DUTY. King’s Col. London, Eli Lilly. 

2:00 P14 460.10 TrkB agonist 7,8-dihydroxyflavone 

prevents 6-hydroxydopamine-induced neurotoxicity on rats. H. 

ZHANG; Y. SHI; Y. SUN; K. YE; J. WANG; Q. YAN*. Sundia 

MediTech Company, Ltd., UCLA, Emory Univ. Sch. of Med., 

Nanjing Univ. 

3:00 Q1 460.11 Physical activity protects the striatum 

against MPTP damage in nonhuman primates. A. M. 

DETTMER*; B. J. LOPRESTI; R. K. LEAK; N. ROCKCASTLE; 

M. J. ZIGMOND; C. A. MATHIS; Z. ZHANG; J. L. CAMERON. 

Univ. Pittsburgh, Univ. of Pittsburgh, Duquesne Univ., Univ. of 

Kentucky. 

4:00 Q2 460.12 Disease modifying treatment with PPARgamma 

agonist rosiglitazone in a progressive mouse model 

of Parkinson’s disease. A. R. CARTA; S. FENU; L. FRAU; M. 

IBBA; J. WARDAS; P. CABONI; E. CARBONI*. Univ. Cagliari, 

Inst. of Pharmacology, Polish Acad. of Sci. 

1:00 Q3 460.13 Treatment of autophagy dysregulation in 

the dj-1 and pink1 deficient dopamine neurons. J. HAN*; K. 

KIM; J. SHIM; J. HA; J. H. SON. Ewha Womans Univ. 

2:00 Q4 460.14 Impact of transduction site and vector 

infusion volume on pleiotrophin-mediated neuroprotection 

in the 6-hydroxydopamine rat model of Parkinson’s disease. 

S. E. GOMBASH*; T. J. COLLIER; B. T. TERPSTRA; B. F. 

DALEY; K. STEECE-COLLIER; S. L. WOHLGENANT; N. 

D. LEVINE; R. J. MANDEL; F. P. MANFRESSON; C. E. 

SORTWELL. Univ. Cincinnati, Michigan State Univ., Univ. of 

Florida. 

3:00 Q5 460.15 Amantadine protects dopamine neurons 

by inducing release of growth factors from astroglial cells. B. 

OSSOLA*; N. SCHENDZIELORZ; S. CHEN; P. MÄNNISTÖ; 

J. HONG. NIEHS, Univ. of Helsinki. 

4:00 Q6 460.16 The neuroprotective mitochondrial effects 

of dopamine neuron stimulating peptide-11. J. TURCHAN- 

CHOLEWO*; K. A. KELPS; D. M. GASH; G. A. GERHARDT; 

L. H. BRADLEY. Univ. of Kentucky. 

1:00 Q7 460.17 • Antiparkinsonism actions of dopamine 

neuron stimulating peptide-11. L. H. BRADLEY*; J. FUQUA; 

A. RICHARDSON; J. TURCHAN-CHOLEWO; Y. AI; K. A. 

KELPS; J. D. GLASS; X. HE; Z. ZHANG; R. GRONDIN; O. M. 

LITTRELL; P. HUETTL; F. POMERLEAU; D. M. GASH; G. A. 

GERHARDT. Univ. of Kentucky, Retired. 


Mon. PM

2:00 Q8 460.18 Suberoylanilide hydroxamic acid (SAHA), 

a histone deacetylase inhibitor, protects dopaminergic 

neurons from neurotoxin-induced damage. S. CHEN*; H. WU; 

B. OSSOLA; N. SCHENDZIELORZ; D. ZHANG; L. QIAN; 

J. HONG; R. LU. Natl. Inst. of Envrn. Hlth. Sciences, Inst. of 

Behavioral Med., Col. of Med. & Hospital, Natl. Cheng-Kung 

Univ., Dept. of Neurology, Changhua Christian Hosp., Div. of 

Pharmacol & Toxicol, Univ. of Helsinki. 

3:00 Q9 460.19 Neuroprotective effects of BDNF 

expressed in reactive astrocytes against 6-OHDA toxicity 

in vitro. Y. TSANG*; K. YUNG. Dept. of Biology, Hong Kong 

Baptist Univ. 

4:00 Q10 460.20 Endogenous expression of brain-derived 

neurotrophic factor and glial cell-line derived neurotrophic 

factor in reactive astrocytes in 6-hydroxydopamine-lesioned 

rats. C. LUI*; L. CHEN; K. YUNG. Hong Kong Baptist Univ., 

Inst. of Neurosciences, The Forth Military Med. Univ. 

1:00 Q11 460.21 Tyrosine hydroxylase-GFP transgenic 

zebra fish: a model for study of neurological disorders. M. 

SUEN*; W. CHAN; W. HUNG; K. YUNG. Dept. of Biology, 

Hong Kong Baptist Univ. 

2:00 Q12 460.22 Unable to Attend - The effect of 

Osteopontin on GDNF and BDNF and protection against 

MPP+-induced tyrosine hydroxylase cell loss in primary 

ventral mesencephalic culture. L. BROOM*; S. ROSE; P. 

JENNER. Kings Col. London. 

3:00 Q13 460.23 Expression of GDNF by specific adult 

striatal neurons and during brain development. M. HIDALGO- 

FIGUEROA*; S. BONILLA; F. GUTIERREZ; J. DIAZ-MARTIN; 

J. LOPEZ-BARNEO; A. PASCUAL*. Inst. De Biomedicina De 

Sevilla (ibis). 

POSTER 

461. Genetic Parkinson’s Disease 



1:00 Q14 461.1 Accumulation of AIMP2, a pathogenic 

substrate of parkin, induces PARP-1 overactivation and 

neuronal death in in vitro and in vivo PD models. Y. LEE*; 

H. KO; J. SHIN; S. KARUPPAGOUNDER; D. SWING; L. 

TESSAROLLO; V. L. DAWSON; T. M. DAWSON. Johns 

Hopkins Med., Natl. Cancer Inst. 

2:00 Q15 461.2 LRRK2 S1647T variant increases the risk 

for Parkinson’s disease in southern China. Z. PEI*; Y. ZHENG; 

Y. LIU; Q. WU; J. CHEN; W. XIAN; J. LI; Z. LIU; L. CHEN. The 

First Affiliated Hospital, Sun Yat-Sen Univ., The First Affiliated 

Hospital, Sun Yat-sen University,. 

3:00 Q16 461.3 • Identification and characterization 

of a Leucine-Rich Repeat Kinase 2 (LRRK2) consensus 

phosphorylation motif. P. P. PUNGALIYA*; Y. BAI; K. 

LIPINSKI; V. ANAND; S. SEN; E. BROWN; B. BATES; P. 

REINHART; A. WEST; W. HIRST; S. BRAITHWAITE. Pfizer, 

Inc, Univ. of Alabama at Birmingham. 

4:00 Q17 461.4 In search of new Parkinson disease 

genes: from human post mortal gene expression profiling to 

functional validation in vitro and in vivo model development. 

J. A. KORECKA*; E. BLAAS; R. EGGERS; R. E. VAN 

KESTEREN; A. B. SMIT; D. F. SWAAB; K. BOSSERS; 

J. VERHAAGEN. Ned. Inst. for Neurosci., Ctr. for 

Neurogenomics and Cognitive Res. 


1:00 Q18 461.5 Human DJ-1-specific transcriptional 

activation of the tyrosine hydroxylase gene. S. ISHIKAWA*; 

T. TAIRA; K. TAKAHASHI-NIKI; T. NIKI; H. ARIGA; S. M. M. 

IGUCHI-ARIGA. Hokkaido Univ., Yamanashi univ. 

2:00 R1 461.6 A novel E3 ligase, RING finger protein 166 

promotes apoptosis in the neurotoxin-induced dopaminergic 

neuronal cell death. C. OH*; B. PARK; I. CHUNG; Y. OH. 

Younsei Univ. 

3:00 R2 461.7 Interaction of hLRRK2 with APC proteins 

in dopaminergic neurons. S. LIU*; D. WANG; A. ILIUK; W. 

TAO; Z. ZHANG. Sanford|Burnham Med. Res. Inst., Purdue 

Univ. 

4:00 R3 461.8 Proteasome inhibition promotes parkin- 

Ubc13 interaction and lysine 63-linked ubiquitination. G. G. 

LIM; K. C. CHEW; X. NG; R. W. SIM; H. TAN; J. M. TAN; K. 

LIM*. NUS Physiol., Natl. Neurosci. Inst., Duke-NUS Grad. 

Med. Sch. 

1:00 R4 461.9 LRRK2 associates with RNA stress 

granules and regulates protein translation. D. CHAN*; G. C. 

SHEN; J. MEI; B. WOLOZIN. Boston Univ. Sch. of Med., Yale 

Univ. 

2:00 R5 461.10 Mutant LRRK2 enhances sensitivity to 

cell stressors in primary neuron cell culture from transgenic 

mouse brain. Y. LIANG; Y. HUANG*; F. C. NUCIFORA; Z. 

PEI; N. ARBEZ; W. W. SMITH; X. WANG; L. TESSAROLO; 

N. G. COPELAND; N. A. JENKINS; D. R. BORCHELT; C. A. 

ROSS. Johns Hopkins Univ. Sch. of Med., The First Affiliated 

Hospital, Sun Yat-Sen Univ., Natl. Cancer Institute, NIH,, Inst. 

for Mol. and Cell Biol., Univ. of Florida. 

3:00 R6 461.11 Pink1 is selectively stabilized on impaired 

mitochondria to activate Parkin. S. JIN*; D. P. NARENDRA; M. 

LAZAROU; C. WANG; A. TANAKA; R. J. YOULE. NINDS/NIH. 

4:00 R7 461.12 Understanding the function of the 

Parkinson’s disease related gene LRRK2 in Caenorhabditis 

elegans: A systems biology guided approach. M. D. 

GUILLILY*; H. LI; N. PYENSON; J. C. LATOURELLE; L. 

RICHTER; R. H. MYERS; J. COLLINS; B. WOLOZIN. Boston 

Univ., Howard Hughes Med. Inst. 

1:00 R8 461.13 Dementia in Parkinson disease: Genetic 

factors influencing its appearance. L. NAVARRO-SÁNCHEZ; 

M. C. RODRÍGUEZ-OROZ; P. MARTÍNEZ-LAGE; J. A. 

OBESO; J. KULISEVSKY; J. PAGONABARRAGA; A. LÓPEZ 

DE MUNAIN; J. MARTÍ-MASSÓ; J. RUIZ-MARTÍNEZ; A. 

GOROSTIDI; A. ESTANGA; J. M. PEREZ-TUR*. Inst. de 

Biomedicina de València, CiberNed, Univ. Clin. and Med. Sch. 

of Navarra, CIMA, Hosp. Donostia, Hosp. Sant Pau. 

2:00 R9 461.14 Genetic variations of transcription 

factor NRF2 might influence age of onset in Parkinson’s 

disease. C. T. RAN*; M. WESTERLUND; A. ANVRET; C. 

LIND; T. WILLOWS; O. SYDOW; D. GALTER; L. OLSON; 

A. CARMINE BELIN. Dept. of Neuroscience, Karolinska 

Institutet, Dept. of Neurology, Karolinska Univ. Hosp. 

3:00 R10 461.15 Genetic analysis and neuropathology in a 

kindred with dementia/parkinsonism and multiple sclerosis. A. 

BOWDER; D. W. DICKSON; B. A. CHASE*; M. L. FILLIPI; Z. 

K. WSZOLEK; K. MARKOPOULOU. Univ. Nebraska-Omaha, 

Mayo Clin., Univ. of Nebraska Med. Ctr., Univ. of Thessaly 

Med. Sch. 

4:00 R11 461.16 Multiple Parkinson disease mutations 

cause LRRK2 to interact closely with microtubules. G. 

M. GAIETTA; C. HO; Y. PENG; N. JORGENSEN; H. 

RIDEOUT; Y. JONES; J. HU; M. TERADA; D. BOASSA; M. 

H. ELLISMAN*; W. T. DAUER. UCSD Sch. Med., Dept. of 

Pathology, Columbia Univ., Univ. of Michigan. 



1:00 R12 461.17 Generation of anti-LRRK2 mouse 

monoclonal antibodies. M. I. ROBERTS*; M. CHOUDHURY; 

C. SMALES; B. SHAH; T. PATEL; L. DUNN; P. LEWIS; J. 

STADDON. Eisai Limited, Inst. of Neurol. 

2:00 R13 461.18 The neurotoxic product of inflammation 

prostaglandin J2 disrupts the PINK1/Parkin pathway in an 

in vitro model of Parkinson’s disease. H. WANG*; M. E. 

FIGUEIREDO-PEREIRA. Hunter Col., Hunter College, City 

Univ. of New York. 

3:00 R14 461.19 • Study on the role of LRRK2 in synaptic 

vesicle trafficking. W. J. MANDEMAKERS*; S. MATTA; V. A. 

MORAIS; A. SNELLINX; M. J. O’NEILL; B. DE STROOPER. 

Dept. Mol. and Developmental Genet., KULeuven - VIB, Eli 

Lilly & Co. Ltd. 

4:00 R15 461.20 High content imaging of parkin 

relocalization to depolarized mitochondria. M. K. MCCOY*; E. 

S. GIDEONS; A. KAGANOVICH; M. R. COOKSON. NIH. 

1:00 R16 461.21 The expression and regulation of leucinerich 

pepeat kinase 2 by microrna in Parkinson disease. H. 

CHO*; H. CAI. NIA/NIH, Neurogenetics/NIA. 

2:00 R17 461.22 Effects of infection on nigral dopaminergic 

neuron death in parkin-null mice. T. A. TRAN*; C. J. BARNUM; 

K. A. HAGAN; S. B. ORTEGA; B. CASEY; J. D. FARRAR; N. 

J. KARANDIKAR; M. S. GOLDBERG; M. G. TANSEY. Emory 

Univ., UT Southwestern Med. Ctr. 

3:00 R18 461.23 A new substrate unravels novel roles of 

the multifaceted E3 ubiquitin ligase Parkin at the mitochondrial 

surface. O. CORTI*; G. BERTOLIN; S. TRAVER; R. 

FERRANDO-MIGUEL; H. ARDILA-OSORIO; A. LOMBÈS; A. 

BRICE. INSERM U 975 - NEB. 

4:00 S1 461.24 • Autophagy in relation to LRRK2 

pathologies in familial and sporadic Parkinson’s disease. Y. 

HUANG*; W. P. GAI; G. HALLIDAY. Prince of Wales Med. 

Res. Inst. & Univ. of New South Wales, Human Physiology, 

Flinders Univ. Sch. of Med. 

1:00 S2 461.25 Generation of autosomal recessive familial 

Parkinson’s disease cell models using the chicken DT40 B 

cell line. E. MINAKAWA*; S. HORIMOTO; K. HIROTA; S. 

TAKEDA; R. TAKAHASHI. Kyoto Univ. Grad. Sch. of Med., 

Kyoto Univ. Grad. Sch. of Sci. 

2:00 S3 461.26 Parkin mediates mitophagy through 

interaction with Ambra1. C. VAN HUMBEECK; H. HOFKENS; 

W. MANDEMAKERS; K. GEVAERT; B. DE STROOPER; W. 

P. VANDENBERGHE*. Univ. Leuven, VIB, Ghent Univ. 

3:00 S4 461.27 Dopamine synthesis and rCBF in 

glucocerebroside-associated parkinsonism. J. C. MASDEU*; 

O. GOKER-ALPAN; A. IANNI; P. KOHN; M. CHALFIN; D. 

EISENBERG; G. LOPEZ; E. SIDRANSKY; K. BERMAN. NIH. 

4:00 S5 461.28 Characterization of the role of PINK1 

in mitochondrial metabolism. C. VAN DEN HAUTE*; B. 

HEEMAN; S. AELVOET; W. KOOPMAN; P. WILLEMS; 

Z. DEBYSER; V. BAEKELANDT. Katholic Univ. Leuven, 

Radboud Univ. 

1:00 S6 461.29 The pink1/parkin-mediated mitophagy is 

compromised by PD-associated mutations. S. GEISLER; A. 

TREIS; K. M. HOLMSTRÖM; D. SKUJAT; F. C. FIESEL; P. J. 

KAHLE*; W. SPRINGER. Hertie Inst. for Clin. Brain Research, 

Univ. of Tübingen, and German Ctr. for Neurodegenerative 

Dis., Univ. Clinics Tübingen. 



2:00 S7 461.30 PINK1 protects against mutant LRRK2induced 

neuronal degeneration by regulating phosphorylation 

of an autophagy protein. S. J. CHERRA*, III; S. M. KULICH; 

G. UECHI; M. BALASUBRAMANI; B. W. DAY; C. T. CHU. 

Univ. Pittsburgh Sch. Med., Veterans Affairs Pittsburgh 


POSTER 

462. Motor Neuron Disease Pathology 



1:00 S8 462.1 Gamma-synuclein transgenic 

mice recapitulate pathological features of amyotrophic 

lateral sclerosis. O. PETERS; S. MILLERSHIP; T. 

SHELKOVNIKOVA; A. HANN; H. VAN DER PUTTEN; 

V. L. BUCHMAN; N. N. NINKINA*. Cardiff Univ., Inst. of 

Physiologically Active Compounds RAS, Novartis Inst. for 

Biomed. Res. 

2:00 S9 462.2 Analysis of differential gene profiles 

in FUS/TLS knock-down motor neurons. S. ISHIGAKI*; Y. 

FUJIOKA; L. J. ZHU; F. URANO; G. SOBUE. Nagoya Univ. 

Grad. Sch. of Med., Univ. of Massachusetts Med. Sch. 

3:00 S10 462.3 Delayed intracerebroventricular VEGF 

administration protects spinal motor neurons against 

excitotoxic death. L. B. TOVAR Y ROMO*; R. TAPIA. Univ. 

Nacional Autónoma De México, Inst. de Geriatría. 

4:00 S11 462.4 Microglial upregulation of progranulin as 

marker of motor neuron degeneration. L. DE MUYNCK; T. 

PHILIPS; H. NGUYEN; B. WEYNANTS; P. VANACKER; J. 

DHONDT; K. SLEEGERS; H. J. SCHELHAAS; M. VERBEEK; 

R. VANDENBERGHE; R. SCIOT; C. VAN BROECKHOVEN; 

D. LAMBRECHTS; F. VAN LEUVEN; L. VAN DEN BOSCH; 

W. ROBBERECHT; P. VAN DAMME*. VIB, K.U.Leuven, KU 

Leuven, Inst. Born-Bunge and Univ. of Antwerp, Radboud 

Univ. Nijmegen Med. Center, Donders Inst. for Brain, 

Cognition and Behaviour, Dept. of Pathology. 

1:00 S12 462.5 Mutant HFE H63D protein is associated 

with prolonged ER stress and decreased neuronal viability in 

ALS. Y. LIU*; S. LEE; E. NEELY; W. NANDAR; Z. SIMMONS; 

J. CONNOR. Penn State Univ. Hershey Med. 

2:00 T1 462.6 Continuous non-invasive infrared 

motion sensing as a measure of neurological disease 

progression in the SOD1-G93A transgenic mouse model of 

ALS. H. DHILLON*; W. REED; K. THOMPSON; J. KIDD; B. 

ALNAKHALA; F. VIEIRA; A. GILL. ALS Therapy Develop. 

Inst., Express Imaging Systems, LLC. 

3:00 T2 462.7 Electrophysiological properties of motor 

neurons in a model of severe SMA: Development in vitro is 

different from development in vivo. M. A. HARRINGTON*; H. 

ZHANG; N. ROBINSON; C. WU; W. WANG. Delaware State 

Univ., Alfred I duPont Children’s Hosp. 

4:00 T3 462.8 Effects of the dynein heavy chain mutation 

(Loa) on neuronal morphology and survival in cranial nerve 

nuclei of the heterozygote Loa mouse. L. M. WIGGINS; 

J. C. STEVENS; A. KUTA; E. M. C. FISHER; C. S. VON 

BARTHELD*. Univ. Nevada Sch. Med., Univ. Col. London. 

1:00 T4 462.9 Role of JNK kinases in SBMA. T. 

SARMA*; S. T. BRADY. Univ. Illinois Chicago. 


Mon. PM

2:00 T5 462.10 Role of RNA processing in the 

pathogenesis of amyotrophic lateral sclerosis. C. LAGIER- 

TOURENNE; M. POLYMENIDOU; K. HUTT; T. Y. LIANG; J. 

MORAN; S. HUELGA; S. LING; C. MAZUR; E. WANCEWICZ; 

Y. SEDAGHAT; C. F. BENNETT; G. W. YEO; D. W. 

CLEVELAND*. Ludwig Inst/UCSD, Isis Pharmaceuticals. 

3:00 T6 462.11 Derlin-1 overexpression ameliorates 

mutant SOD1-mediated endoplasmic reticulum stress by 

reduction of accumulation of mutant SOD1. A. MORI*; 

S. YAMASHITA; K. UCHINO; T. SUGA; T. IKEDA; K. 

TAKAMATSU; M. ISHIZAKI; T. KOIDE; E. KIMURA; S. MITA; 

Y. MAEDA; T. HIRANO; M. UCHINO. Kumamoto University, 

Dept. of Neurol., Nishi-Kumamoto Hospital, Dept. of Neurol. 

4:00 T7 462.12 ALS-associated mutations in TDP-43 

increase its stability and promote TDP-43 complexes with 

FUS/TLS. S. LING*; C. ALBUQUERQUE; J. HAN; H. ZHOU; 

D. W. CLEVELAND. UCSD, Ludwig Inst. for Cancer Res. 

1:00 T8 462.13 DJ-1 forms complexes with mutant SOD1 

and ameliorates its toxicity. S. YAMASHITA*; A. MORI; E. 

KIMURA; S. MITA; Y. MAEDA; T. HIRANO; M. UCHINO. 

Kumamoto Univ., Nishi-Kumamoto Hosp. 

2:00 T9 462.14 The small heat shock protein b8 

promotes autophagic removal of misfolded proteins involved 

in amyotrophic lateral sclerosis. A. POLETTI*; V. CRIPPA; 

P. RUSMINI; D. SAU; E. BOLZONI; E. ONESTO; A. 

BONCORAGLIO; M. GALBIATI; S. CARRA; E. FONTANA; M. 

MARINO; C. BENDOTTI; S. DE BIASI. Universita’ degli Studi 

di Milano, Univ. Med. Ctr. Groningen, Inst. Mario Negri. 

3:00 T10 462.15 Axonal transport is impaired in a mouse 

model of SPG10. K. N. KARLE*; D. MOECKEL; L. SCHOELS. 

Hertie Inst. For Clin. Brain Res. 

4:00 T11 462.16 The unfolded protein response in familial 

amyotrophic lateral sclerosis. L. WANG*; B. POPKO; R. P. 

ROOS. Univ. Chicago. 

1:00 T12 462.17 Gene expression profiles of lymphocytes 

from amyotrophic lateral sclerosis patients show deregulation 

of the ubiquitin/proteasome pathway. J. MOUGEOT*; A. E. 

PRICE; E. J. ARMSTRONG; B. R. BROOKS. Carolinas Med. 

Ctr. - Carolinas Neuromuscular/ALS-MDA Ctr. 

2:00 T13 462.18 Paradoxical effect of serine racemase 

knockout in the G93A mSOD1 mouse model of amyotrophic 

lateral sclerosis (ALS). M. THOMPSON*; R. REED; P. 

BENNETT; S. BARGER; J. CROW. The Univ. of Arkansas For 

Med. Sci. 

3:00 T14 462.19 Potential role of s-nitrosylation of protein 

disulfide isomerase in the aggregation of mutant cu,znsuperoxide 

dismutase in amyotrophic lateral sclerosis. 

J. SUNG*; T. NAKAMURA; J. LEE; J. LIM; K. LEE; S. A. 

LIPTON. Seoul Nat’l Univ. Hosp., Sanford-Burnham Med. 

Res. Inst. 

4:00 T15 462.20 Rna targets of tdp-43 identified by uvclip 

are deregulated in amyotrophic lateral sclerosis. J. 

ROBERTSON*; T. SANELLI; L. ZINMAN; S. XIAO. Univ. of 

Toronto. 

1:00 T16 462.21 Genetic deletion of galectin-3 exacerbates 

neuroinflammation and accelerates disease progression and 

demise in a SOD1 G93A mouse model of ALS. B. J. LERMAN; 

E. P. HOFFMAN; M. L. SUTHERLAND; D. K. HSU; F. LIU; S. 

M. KNOBLACH*. George Washington Univ. Sch. of Med. and 

Hlth. Sci., Children’s Natl. Med. Cr, NIH, Univ. of California, 

Davis. 


2:00 T17 462.22 Motor behavior tests to detect the early 

symptoms in a mouse ALS model. A. E. VERCELLI*; M. 

BOIDO; G. SPIGOLON; A. PIRAS; V. VALSECCHI. Neurosci. 

Inst. of Turin. 

3:00 T18 462.23 Rapid onset dystonia-parkinsonism: 

Symptoms in a mouse deficient in Na,K-ATPase alpha3. K. 

J. SWEADNER*; A. SACINO; T. M. YANG; J. B. LINGREL; A. 

BRASHEAR. Massachusetts Gen Hosp, Univ. of Cincinnati, 

Wake Forest Univ. 

4:00 U1 462.24 Voltage-dependent anion channel (VDAC) 

content varies in brain, spinal cord and muscle mitochondria 

between wild-type and human mutant G93A superoxide 

dismutase (SOD1) familial amyotrophic lateral sclerosis (fALS) 

transgenic Taconic Sprague Dawley rats. N. KUBALIK; A. V. 

PANOV; R. A. HEMENDINGER*; B. R. BROOKS. Carolinas 

Med. Ctr. 

1:00 U2 462.25 Regulation of spinal motor neuron 

differentiation and degeneration in spinal muscular atrophy. H. 

WANG; N. MILLER; Y. MA*. Northwestern Univ. Feinberg Sch. 

of Med., Northwestern University, CMRC. 

POSTER 

463. Autism: Genetic and Animal Models III 



1:00 U3 463.1 Abnormal social behavior and altered 

expression of MeCP2: Importance of maternal diet. 

T. M. REYES*; E. HOLLENBECK; Z. VUCETIC. Univ. 

Pennsylvania. 

2:00 U4 463.2 Haploinsufficiency of Shank3 causes 

impairments in synaptic transmission and plasticity in the 

hippocampus. O. BOZDAGI*; T. SAKURAI; S. PATIL; D. 

PAPAPETROU; D. L. DICKSTEIN; N. TAKAHASHI; L. KRUG; 

X. WANG; G. W. HUNTLEY; Q. ZHOU; P. R. HOF; J. D. 

BUXBAUM. Mt Sinai Sch. Med. 

3:00 U5 463.3 Altered cortical connectivity in monoamine 

oxidase A knockout mice. Y. LU*; J. L. ZHANG; R. D. 

DARLING; L. ALZGHOUL; K. L. SIMPSON; K. CHEN; J. C. 

SHIH; R. C. S. LIN. Tougaloo Col., Univ. of Mississippi Med. 

Ctr., USC. 

4:00 U6 463.4 Perinatal exposure to specific serotonin 

reuptake inhibitor alters the cardiovascular function and 

medullary serotonergic circuitry in adult rats. C. HSU; C. LEE; 

M. TSAI; R. LIN; R. CHEN*. Natl. Taiwan Univ., Natl. Ilan 

Univ., Mississippi Med. Ctr. 

1:00 U7 463.5 Deficient metabotropic glutamate receptor 

dependent long-term depression in the mouse model of 

tuberous sclerosis. B. D. AUERBACH*; E. OSTERWEIL; M. F. 

BEAR. HHMI/MIT. 

2:00 U8 463.6 Selective deficits in social interactions 

in Shank3 mutant mice. M. YANG*; M. SCATTONI; M. J. 

HARRIS; A. M. KATZ; R. SAXENA; S. M. TURNER; L. M. 

WOLDEYOHANNES; F. I. ROULLET; J. L. SILVERMAN; O. 

BOZDAGI; T. SAKURAI; J. D. BUXBAUM; J. N. CRAWLEY. 

NIH, Natl. Inst. of Mental Hlth., Inst. Superiore di Sanità, 

Mount Sinai Sch. of Med. 

3:00 U9 463.7 Epac2 mutation in autism alter the 

probability of glutamate release at mossy fiber synapses. K. 

QIAN*; A. HUI; Y. LU. LSU. 



4:00 U10 463.8 Early life exposure of rats to a 5HT1B 

receptor (5HT1BR) agonist, like exposure to a selective 

serotonin reuptake inhibitor (SSRI), induces persistent 

sensory dysfunction, neophobia and disruption of social 

behaviors. N. KHATRI*; F. RODRIGUEZ-PORCEL; E. 

NICHOLS; R. C. S. LIN; I. A. PAUL. Univ. Of Mississippi Med. 

Ctr. 

1:00 U11 463.9 Genome wide expression profiling and 

CNV analysis of LCLs from autism patients. R. LUO*; I. 

VOINEAGU; M. REBECCA; J. OU; D. GESCHWIND. UCLA. 

2:00 U12 463.10 VLDLR-overexpressing transgenic rats: 

Evaluation as an animal model of autism. K. IWATA*; H. 

MATSUZAKI; N. IZUMO; Y. ICHITANI; N. TAKEI; N. MORI. 

Hamamatsu Univ., Yokohama Col. of Pharm., Univ. of 

Tsukuba, Hamamatsu Univ. Sch. of Med. 

3:00 U13 463.11 Altered expression of noradrenergic 

tyrosine hydroxylase immunoreactivity of locus coeruleus 

circuitry following perinatal manipulations in the rodent. J. 

ZHANG*; R. D. DARLING; L. ALZGHOUL; K. L. SIMPSON; K. 

CHEN; J. C. SHIH; R. C. LIN. Univ. of Mississippi Med. Ctr., 

USC. 

4:00 U14 463.12 Dysregulation of serotonin during early 

development altered callosal connectivity in the rodent. L. 

ALZGHOUL*; J. ZHANG; R. D. DARLING; I. A. PAUL; K. 

L. SIMPSON; K. CHEN; J. C. SHIH; R. C. S. LIN. Univ. of 

Mississippi Med. Ctr., USC. 

1:00 U15 463.13 Potential interaction between immune 

activation and the DISC1 mutation in the BTBR T+tf/J mouse 

model of autism. R. H. BENNO*; M. CILIBRASI; N. SCHANZ; 

B. SMITH; T. RENDON. William Paterson Univ. New Jersey. 

2:00 U16 463.14 Neonatal exposure of rats to selective 

serotonin reuptake inhibitors (SSRIs) disrupts maternal 

behavior in female rats. D. L. GREEN*, JR; F. RODRIGUEZ- 

PORCEL; R. C. S. LIN; I. A. PAUL. Univ. of Mississippi Med. 

Ctr. 

3:00 U17 463.15 Characterization of Pten knockdown on 

synaptic phenotypes in primary mouse cortical neurons. A. V. 

SHRIKHANDE*; A. W. PROBERT; E. R. GUILMETTE; J. E. 

FINLEY; M. BEYNA; D. T. STEPHENSON; R. H. RING. Pfizer 

Global Res. & Dev. 

4:00 U18 463.16 Oxytocin reverses the social deficit of 

rats with neonatal amygdala lesions. A. G. GITTIS*; A. M. 

ALFIERI. Westminster Col. 

1:00 V1 463.17 Neonatal exposure to citalopram 

functionally alters the norepinephrine system in male rats. R. 

D. DARLING*; L. ALZGHOUL; J. ZHANG; J. W. DUNCAN; N. 

KHATRI; I. A. PAUL; K. L. SIMPSON; R. C. S. LIN. Univ. of 

Mississippi Med. Ctr. 

2:00 V2 463.18 Comprehensive behavioral phenotyping 

of neuroligin-2 mutant mice. S. M. TURNER*; M. J. HARRIS; 

R. SAXENA; J. L. SILVERMAN; J. N. CRAWLEY. Natl. Inst. of 

Mental Hlth. 

3:00 V3 463.19 • Reduced BDNF gene expression and 

impaired neurogenesis in the hippocampus of the inbred 

mouse strain BTBR. E. ARNOLD*; S. M. O’NEILL; H. 

SAMAROO; D. HANNAH; S. SHETTY; A. TIWARI; V. VAIDYA; 

B. CAMPBELL; R. H. RING; D. T. STEPHENSON. Neurosci. 

Res. Unit, Pfizer Global Res. and Develop., Tata Inst. of 

Fundamental Res. 



4:00 V4 463.20 Autistic-like phenotypes in sAPP-a 

overexpressing transgenic mice. A. R. BAILEY*; H. HOU; D. 

OBREGON; J. TIAN; J. WINDERBAUM FERNANDEZ; M. 

BENGSTON; T. MURPHY; Y. ZHAO; J. TAN. Rashid Lab. 

For Developmental Neurobio. Silver Child Develop. Ctr., 

Neuroimmunology Laboratory, Col. of Medicine, Univ. of South 

Florida, Rothman Ctr. for Neuropsychiatry, Col. of Medicine, 

Univ. of South Florida, All Children’s Hosp., Sch. of Medicine, 


1:00 V5 463.21 Partial rescue of social deficits in the 

BTBR T+tf/J mouse model of autism by AMPA receptor 

modulator CX546. J. L. SILVERMAN*; S. M. TURNER; J. N. 

CRAWLEY. NIH, Natl. Inst. of Mental Hlth. 

2:00 V6 463.22 Metabotropic glutamate receptordependent 

long-term depression in ΔRG mouse model of 

tuberous sclerosis. I. CHEVERE*; J. M. MAKI; H. KAPHZAN; 

E. KLANN. New York Univ. 

3:00 V7 463.23 Neonatal and juvenile behavioral 

phenotypes in mice carrying a deletion of the neuroligin-4 

gene. A. M. KATZ*; L. WOLDEYOHANNES; M. YANG; J. L. 

SILVERMAN; J. N. CRAWLEY. Natl. Inst. of Health, Natl. Inst. 

of Mental Hlth. 

4:00 V8 463.24 Sept5 in the amygdala is a determinant for 

social behavior in mice. K. M. HARPER*; T. HIRAMOTO; G. 

SUZUKI; K. TANIGAKI; G. KANG; W. S. TRIMBLE; N. HIROI. 

Albert Einstein Col. of Med., Shiga Med. Ctr., The Hosp. for 

Sick Children. 

1:00 V9 463.25 Fluorescent based measures of 

altered glutamatergic activity following MeCP2 and Mef2A 

gene knockdowns. A. W. PROBERT JR*; C. LIU; E. R. 

GUILMETTE; A. V. SHRIKHANDE; N. I. POZDNYAKOV; J. 

E. FINLEY; C. J. SOMPS; D. T. STEPHENSON; R. H. RING. 

Pfizer Inc. 

2:00 V10 463.26 BTBR T+tf/J mice show deficits in 

seminatural visible burrow systems. D. BLANCHARD*; R. 

L. H. POBBE; E. B. DEFENSOR; B. L. PEARSON; V. J. 

BOLIVAR; R. J. BLANCHARD. Univ. Hawaii, Wadsworth 

Center, New York State Dept. of Hlth. 

3:00 V11 463.27 Expression of repetitive and stereotyped 

behaviors of C57BL/6J versus BTBR inbred mouse strains. R. 

L. POBBE*; B. L. PEARSON; E. B. DEFENSOR; L. OASAY; 

D. BLANCHARD; R. J. BLANCHARD. Univ. of Hawaii, John A 

Burns Sch. of Med., Dept Psychology. 

4:00 V12 463.28 C57Bl/6J mice fail to display social 

novelty preference in a modified three-chamber task. B. 

L. PEARSON*; E. B. DEFENSOR; R. L. H. POBBE; D. 

C. BLANCHARD; R. J. BLANCHARD. Psychology, Univ. 

of Hawaii, Pacific Biosci. Res. Ctr., John A Burns Sch. of 

Medicine, Univ. of Hawaii. 

1:00 V13 463.29 Postnatal and peripubertal risperidone 

treatment alters behavior in young adult rats. M. S. 

GRIFFITH*; J. FRANKS; K. COLEMIRE; M. E. BARDGETT. 

Northern Kentucky Univ. 

2:00 V14 463.30 The autism spectrum disorder (ASD) 

risk genes MET and PLAUR differentially impact cortical 

development. K. L. EAGLESON*; D. B. CAMPBELL; B. L. 

THOMPSON; M. BERGMAN; P. LEVITT. Keck Sch. of Med. 

At USC, Vanderbilt Univ. 


Mon. PM

POSTER 

464. Epilepsy: Epileptogenesis II 



1:00 V15 464.1 Epilepsy-induced pathologic plasticity 

and NMDA alterations in the malformed brain of human 

FCD patients and MAM-pilocarpine rat model. A. FINARDI; 

F. COLCIAGHI; P. NOBILI; A. FRASCA; D. LOCATELLI; 

P. D’ERRICO; S. CAPRA; L. CASTANA; G. LORUSSO; A. 

VEZZANI*; G. BATTAGLIA. Neurolog. Inst. “C. Besta”, Inst. 

Mario Negri, Niguarda Gen. Hosp. 

2:00 V16 464.2 Impact of neuronal subtypes in 

epileptogeneis of human gelastic seizures with hypothalamic 

hamartoma. G. LI*; Q. LIU; K. YANG; M. GAO; Y. JIN; Y. 

CHANG; J. KERRIGAN; J. WU. Barrow Neurol Inst. 

3:00 V17 464.3 • In vivo studies of the effects of kindling 

on tonic and phasic glutamate release in subregions of 

the rat hippocampus in an animal model of epilepsy. V. A. 

DAVIS*; M. E. DEEL; M. L. STEPHENS; R. M. ALCALA; J. E. 

QUINTERO; F. POMERLEAU; P. HUETTL; J. T. SLEVIN; G. 

A. GERHARDT. Univ. of Kentucky - Cenmet. 

4:00 V18 464.4 Pilocarpine-induced status epilepticus 

causes hyper-excitatory propagation and interneuron loss 

in rat agranular insular cortex. S. N. FUJITA*; S. CHEN; N. 

MIZOGUCHI; N. KOSHIKAWA; M. KOBAYASHI. Nihon Univ. 

Sch. of Dent. 

1:00 W1 464.5 Synaptic alterations in a rat model 

of epileptogenesis induced by atypical febrile seizure. P. 

N. AWAD; B. CHATTOPADHYAYA*; G. DI CRISTO; L. 

CARMANT. CHU Ste. Justine, Ctr. Du Recherche. 

2:00 W2 464.6 Neocortical dysfunction is associated 

with subcortical network changes in limbic seizures: 

Investigations in a rodent model with high field BOLD fMRI. 

J. E. MOTELOW*; A. M. MISHRA; D. J. ENGLOT; B. G. 

SANGANAHALLI; F. HYDER; H. BLUMENFELD. Yale Sch. of 

Med. 

3:00 W3 464.7 • Thiol oxidation and NR2B-containing 

NMDA receptor over expression: An early phenomenon in 

pilocarpine-treated hippocampal neurons. R. DI MAIO*; P. 

MASTROBERADINO; X. HU; J. GREENAMYRE. Univ. of 

Pittsburgh. 

4:00 W4 464.8 NMDAR-mediated synaptic current 

property alteration following neonatal hypoxic seizures in 

immature rats. C. ZHOU*; P. M. KLEIN; F. E. JENSEN. 

Children’s Hosp. Boston. 

1:00 W5 464.9 Hypoxia induced early life seizures lead 

to increased hippocampal mossy fiber sprouting with no 

associated cell death. P. KLEIN*; C. HILARIO-GOMEZ; B. 

KOSARAS; S. N. RAKHADE; F. E. JENSEN. Children’s Hosp. 

Boston, Children’s Hosp. Boston/Harvard Med. Sch. 

2:00 W6 464.10 • Molecular players of early-life seizureinduced 

preconditioning. L. K. FRIEDMAN*; J. MANCUSO; 

A. SAGYHAN; D. A. IACOBAS; S. IACOBAS; D. SPRAY. 

NYCOM/NYIT, New York Col. of Osteo. Med., Albert Einstein 

Col. of Med. 

3:00 W7 464.11 Microglia (MG) and astroglia (AG) short 

term and long term response in two epilepsy models: The 

pentylenetetrazole (PTZ) model of repeated seizures and the 

L-methionine sulfoximine (MSO) model. H. J. BIDMON*; N. 

PALOMERO-GALLAGHER; E. J. SPECKMANN; K. ZILLES. 

Univ. of Duesseldorf, Res. Ctr. Juelich, Univ. of Muenster, 

Res. Ctr. Juelich. 


4:00 W8 464.12 Behavioral effects of RDX on adult 

zebrafish. K. WONG*; L. R. WILLIAMS; A. STEWART; J. 

GOODSPEED; C. SUCIU; J. CACHAT; A. V. KALUEFF. 

Tulane Univ. Sch. of Med., US Army Publ. Hlth. Command. 

1:00 W9 464.13 Oxidative/nitrosative stress and 

permanently impaired mitochondrial redox status during 

epileptogenesis. K. RYAN; S. WALDBAUM; L. LIANG; C. 

RIVARD; M. N. PATEL*. Univ. Colorado, Denver. 

2:00 W10 464.14 Decreased respiratory capacity and 

glycolytic rates in a rat model of temporal lobe epilepsy 

revealed by metabolic flux analysis of hippocampal 

synaptosomes. S. ROWLEY*; M. PATEL. Univ. of Colorado 

Denver. 

3:00 W11 464.15 • Piriform cortex kindling enhances 

thalamic MD evoked potential amplitude by RTN or LO. D. X. 

ZHANG*; E. H. BERTRAM. Univ. Virginia. 

4:00 W12 464.16 Extracellular hippocampal amino acid 

characterization of phenytoin-resistant hippocampal-kindled 

rats. H. L. MUNGUÌA*; L. ROCHA. CINVESTAV. 

1:00 W13 464.17 Somatic translocation: A novel mechanism 

of granule cell dendritic dysmorphogenesis and dispersion. 

B. L. MURPHY*; S. C. DANZER. Cincinnati Children’s Hosp. 

Med. Ctr., Univ. of Cincinnati. 

2:00 W14 464.18 Early gene transcription after traumatic 

brain injury by lateral fluid percussion in the rat. Y. WANG*; P. 

A. MULLER; A. IGLESIAS; S. RAKHADE; F. E. JENSEN; A. 

ROTENBERG. CHILDREN HOSPITAL BOSTON, HARVARD 

MEDICAL SCHOOL. 

3:00 X1 464.19 Fine mapping of a seizure-induced 

cell death locus on mouse chromosome 15. P. E. 

SCHAUWECKER*. USC. 

4:00 X2 464.20 Neuronal death and phenytoin resistance 

in post-traumatic epileptogenesis. Y. BERDICHEVSKY*; V. 

DZHALA; K. STALEY. Massachusetts Gen. Hosp., Harvard 

Med. Sch. 

1:00 X3 464.21 Short duration seizures produce 

hippocampal cell loss: Seizure frequency predicts the amount 

of loss in an animal model of Temporal Lobe Epilepsy. S. 

J. GREENWOOD*; A. BEZSONOVA; A. CASABIANCA; B. 

ANDERSON. SUNY Stony Brook. 

2:00 X4 464.22 No visible immunohistochemical 

abnormality of migrating neurons in Efhc1-deficient mouse. 

T. SUZUKI*; I. INOUE; K. YAMAKAWA. RIKEN, BSI, Lab. for 

Neurogenetics. 

3:00 X5 464.23 MRI volumetry in the pilocarpine and 

kainic acid rodent models of epilepsy. R. S. POLLI*; J. M. 

MALHEIROS; A. TANNÚS; L. COVOLAN. Univ. Federal De 

São Paulo, Physics Institute, Univ. of São Paulo. 

4:00 X6 464.24 • Effects of peripheral inflammation on 

hippocampal synaptic plasticity. K. RIAZI*; A. Y. REID; M. A. 

GALIC; J. B. KUZMISKI; K. A. SHARKEY; Q. J. PITTMAN. 

Univ. of Calgary. 



POSTER 

465. Ischemia: Cellular and Molecular Mechanisms II 



1:00 X7 465.1 Proteomic analysis of primary cerebral 

cortical neurons in chemical ischemia. J. SEO*. Biomed. Sci. 

Inst. 

2:00 X8 465.2 Zinc promotes hypoxic astrocytic 

cell death by augmenting hypoxia-induced HIF-1 alpha 

stabilization. R. PAN*; W. LIU; K. J. LIU. Univ. of New Mexico, 

Hlth. Sci. Center, Univ. of New Mexico. 

3:00 X9 465.3 Expression and activity of Na-K ATPase in 

ischemic injury of cultured astrocyte. M. KIM*. Colleage Med. 

4:00 X10 465.4 • The −511 C→T polymorphisms in the 

IL-1 beta gen promoter enhance the NOS2A -2600(CCTTT)n 

pentanucleotide microsatellite risk to development of cerebral 

palsy in patient with antecedent of hypoxia-ischemia perinatal. 

J. A. GONZALEZ-BARRIOS*; K. M. GIL-BECERRIL, 2006; 

M. R. THOMPSON-BONILLA, 2009; J. L. MERINO-GARCÍA, 

2001; H. N. MORENO-SANDOVAL, 2009; B. A. LEÓN- 

CHÁVEZ, 2004; D. MARTÍNEZ-FONG, 1985. Hosp Regional 

Octubre, ISSSTE, Benémerita Univ. Autónoma de Puebla, Ctr. 

de Investigación y Estudios Avanzados. 

1:00 X11 465.5 Reperfusion rather than ischemia drives 

the formation of ubiquitin aggregates in the mouse neocortex 

after middle cerebral artery occlusion. K. HOCHRAINER*; 

K. JACKMAN; L. GARCIA-BONILLA; J. ANRATHER; C. 

IADECOLA. Weill Cornell Med. Col. 

2:00 X12 465.6 Assessment of hippocampal cannabinoid 

CB1 receptor function in female rats subjected to focal brain 

ischemia. C. J. FOWLER*; M. ROJO; I. SÖDERSTRÖM; T. 

OLSSON. Umea Univ. 

3:00 X13 465.7 Hypoxia-induced alterations in the 

embryonic cerebral cortex are mediated by lysophosphatidic 

acid (LPA) signaling. S. T. TEO*; M. LIN; J. CHUN. Mol. 

Biology, The Scripps Res. Inst. 

4:00 X14 465.8 KLF6 and HSP47 are colabled in reactive 

astrocytes of the mouse hippocampus following transient 

global forebrain ischemia. L. KYUNG-EON*; K. CHO; S. KIM. 

The Catholic Univ. of Korea. 

1:00 X15 465.9 Expressions of BMPs and noggin during 

subacute and chronic stages following experimental ischemic 

stroke. E. PARK*; M. LEE; J. A. SHIN; T. KIM; J. H. CHOI. 

Deparment of Pharmacol. Med. Sch. of Ewha Womans Univ., 

Dept. of Brain & Cognitive Sciences, Brain Dis. Res. Inst. 

2:00 X16 465.10 Recurrent hypoglycemia increases oxygen 

- Glucose deprivation induced damage in hippocampal 

organotypic slices. K. DAVE*; A. PILEGGI; M. A. PEREZ- 

PINZON; A. P. RAVAL. Univ. Miami Sch. Med. 

3:00 X17 465.11 Magnocellular neuroendocrine cells 

dramatically resist stroke-like injury in live brain slices 

compared to neocortical pyramidal neurons. D. C. BRISSON*; 

R. D. ANDREW. Queen’s Univ. 

4:00 X18 465.12 Cell-specific expression of phospho-S6 

ribosomal protein in PLP-EGFP transgenic mice following 

cerebral hypoxic-ischemic injury. L. L. JANTZIE*; J. YU; D. M. 

TALOS; M. HU; M. C. JACKSON; F. E. JENSEN. Children’s 

Hosp. Boston. 

1:00 Y1 465.13 Ischemic postconditioning by prolyl 

hydroxylase inhibition requires HIF-1alpha and NF-kB p50. M. 

E. OGLE*; X. GU; S. YU; L. WEI. Emory Univ. 



2:00 Y2 465.14 Molecular genetic dissection of the 

neurovascular niche after stroke: Cellular signaling systems 

in post-stroke neurogenesis. A. J. BRUMM*; M. MACHNICKI; 

G. COPPOLA; D. GESCHWIND; S. T. CARMICHAEL. Univ. of 

California Los Angeles. 

3:00 Y3 465.15 Role of protein ISGylation following stroke. 

V. NAKKA; B. LANG; D. LENSCHOW; R. J. DEMPSEY*; R. 

VEMUGANTI. UNiv Wisconsin, Washington Univ. 

4:00 Y4 465.16 Attenuated post-stroke angiogenic 

responses in genetic variant of BDNF (Met/Met) mice are 

rescued by CD36 deficiency. L. QIN*; E. KIM; R. RATAN; 

F. S. LEE; S. CHO. Burke Med. Res., Dept. of Neurol. and 

Neuroscience, Weill Med. Col. of Cornell Univ., Dept. of 

Psychiatry, Dept. of Pharmacology, Weill Med. Col. of Cornell 

Univ. 

1:00 Y5 465.17 Caveolin-1 mediates tissue plasminogen 

activator-induced MMP-9 secretion in cultured brain 

microvascular endothelial cells. C. CHEN*; J. LIU; W. LIU; K. 

J. LIU. Univ. of New Mexico Hlth. Sci. Ctr. 

2:00 Y6 465.18 p90 RSK activation contributes to cerebral 

ischemic damage via phosphorylation of Na + /H + exchanger 

isoform 1. N. MANHAS; Y. SHI; J. TAUNTON; D. SUN*. Univ. 

Wisconsin Med. Sch., Univ. of Wisconsin-Madison, Univ. of 

California. 

3:00 Y7 465.19 • Regulation of the L-arginine 

metabolome during ischemic stroke: A role for 17β-estradiol. 

C. M. BROWN*; N. C. FILIPEK; J. O. BECKER; A. N. 

HOOFNAGLE; P. M. WISE. Univ. of Washington. 

POSTER 

466. Ischemia: Neuroprotection II 


Mon. 1:00 PM – San Diego Convention Center, Halls B-H 

1:00 Y8 466.1 Cortical neuron rescue from glutamate 

toxicity by Activin A requires activin receptor I kinase activity. 

A. K. HALL*; J. L. RHODES. Case Western Res. Univ. Sch. 

Med. 

2:00 Y9 466.2 Vagus nerve stimulation in focal cerebral 

ischemia. I. AY*; H. AY; A. G. SORENSEN. Mass Gen. Hosp. 

3:00 Y10 466.3 Regulation of RyR-2 expression in hypoxic 

injury to spinal cord dorsal column in vitro. S. K. AGRAWAL*; 

V. KESHERWANI. Univ. Nebraska Med. Ctr. 

4:00 Y11 466.4 Salvianolic acid B protect the blood-brain 

barrier in rats after cerebral ischemia by inhibiting MAPK 

pathway. Q. LI; W. FENG; M. TANG*. Beijing Univ. of Chinese 

Med., Univerisity of Pittsburgh. 

1:00 Y12 466.5 Functional recovery by low dose of 

erythropoietin in a PVL model of P3 rats. K. MIZUNO; R. 

NISHIGAKI; S. MISUMI; M. FUJITA*; H. TOGARI; H. HIDA. 

Nagoya City Univ. Grad Sch. Med. Sci. 

2:00 Y13 466.6 Niaspan treatment induces 

neuroprotection after stroke. A. SHEHADAH*; J. CHEN; A. 

ZACHAREK; Y. CUI; M. ION; C. ROBERTS; A. KAPKE; M. 

CHOPP. Henry Ford Hosp., Oakland Univ. 

3:00 Y14 466.7 Photochemically induced thrombosis 

in the rats’ brain cortex and treatment with plaferon-LB. M. 

NEBIERIDZE*; N. MITAGVARIA; I. ERKOMAISHVILI; N. 

PIPIA. Beritashvili Inst. of Physiol. 


Mon. PM

4:00 Y15 466.8 Hippocampal cell damage in mice with 

cholinergic hypofunction is gender-dependent and genotypeindependent. 

D. F. GONÇALVES*; P. GUIDINE; H. LEITE; V. 

PRADO; M. PRADO; G. PEREIRA; A. MASSENSINI. Federal 

Univ. of Minas Gerais, Robarts Res. Inst. and Univ. of Western 

Ontario. 

1:00 Y16 466.9 Mechanisms of estrogens’ dosedependant 

neuroprotective and neurodamaging effects in 

experimental models of cerebral ischemia. J. O. STROM*; E. 

THEODORSSON; A. THEODORSSON. Clin. & Exper Med. 

2:00 Y17 466.10 AICAR preconditioning in cultured murine 

cortical neurons: Effects on mitochondrial bioenergetics and 

neuronal Ca2 + homeostasis. U. ANIL KUMAR*; P. WEISOVÁ; 

C. G. CONCANNON; J. H. M. PREHN. Royal Col. of 

Surgeons In Ireland. 

3:00 Y18 466.11 SDF-1 and GABA influence new synaptic 

inputs to developing neurons in the borderzones of cerebral 

infarcts. B. BHATTACHARYYA*; A. ARDELT; D. REN; R. J. 

MILLER. Northwestern Univ., Univ. of Chicago. 

4:00 Z1 466.12 Effects of hyperoxia on brain tissue 

oxygen tension in non-sedated, non-anesthetized Arctic 

ground squirrels. Y. MA*; S. WU; L. DUFFY. Univ. Alaska, 

Univ. of Alaska Fairbanks. 

1:00 Z2 466.13 Neuroprotection by 

N-linoleoylethanolamine in vitro and in vivo. S. KAJA*; R. 

DUNCAN; P. GARG; S. L. BURROUGHS; P. KOULEN. Univ. 

of Missouri - Kansas City, Univ. of Texas Southwestern Med. 

Ctr. at Dallas. 

2:00 Z3 466.14 Improved neuroprotection induced by prior 

administration of microdose citicoline via brain extracellular 

space in experimental ischemia. F. XU*; H. HAN; J. YAN; Q. 

HE; H. CHEN; C. HOU; W. XU; X. XU. Peking Univ. Third 

Hosp., Peking Univ. Hlth. Sci. Ctr. 

3:00 Z4 466.15 Ibudilast, a phosphodiesterase inhibitor, 

protects against ischemic brain injury in rats. Y. KO*; E. CHO; 

J. S. KIM; J. LEE. Univ. of Ulsan Col. of Med. 

4:00 Z5 466.16 Adenosine kinase is a therapeutic target 

for antisense strategies for stroke prevention. H. SHEN*; T. A. 

LUSARDI; J. LAN; D. J. POULSEN; D. BOISON. R.S. Dow 

Neurobio. Labs, Univ. of Montana. 

1:00 Z6 466.17 Valproic acid promotes angiogenesis in a 

rat model of transient focal cerebral ischemia. Z. WANG*; L. 

TSAI; P. LEEDS; D. CHUANG. Mol. Neurobiol. Section, NIH/ 

NIMH. 

2:00 Z7 466.18 A dietary polyphenol resveratrol protects 

against endothelial and neuronal injury in models of stroke. 

D. L. CLARK; R. THOMPSON; A. INSTITORIS; L. WANG; 

A. KULYNYCH; S. SUN; D. BUSIJA; U. I. TUOR*. Univ. of 

Calgary, Wake Forest Univ., Inst. Biodiagnostics (West) NRC. 

3:00 Z8 466.19 Neuroprotection from ischemia with 

vagal nerve stimulation may be model dependent. Z. SUN; 

T. HIRAKI; W. BAKER; J. H. GREENBERG*. Gen. Hosp. of 

Chinese PLA, Univ. of Pennsylvania, Univ. Pennsylvania. 

4:00 Z9 466.20 • Vitamin D hormone enhances the 

neuroprotective efficacy of progesterone in different models of 

stroke. F. ATIF*; I. SAYEED; T. ISHRAT; F. HUA; J. WANG; D. 

G. STEIN. Emory Univ. 


1:00 Z10 466.21 Aberrant Cdk5 causes ischemic injury 

in stroke. C. CASTRO*; D. MEYER; Z. TAN; J. W. KANSY; 

A. TOZZI; M. DI FILIPPO; V. DI NAPOLI; S. BENKOVIC; D. 

B. MILLER; P. CALABRESI; C. L. ROSEN; J. A. BIBB. UT 

Southwestern Med. Ctr., The Univ. of Texas Southwestern 

Med. Ctr., West Virginia Univ. Sch. of Med., Clinica 

Neurologica, Universitá di Perugia, The Rockefeller Univ., 

Centers for Dis. Control and Prevention, CDC-NIOSH. 

2:00 Z11 466.22 ERK1/2 and Akt are regulated by aged 

garlic extract in cerebral Ischemia. K. I. ITURRALDE*; M. 

ESPINOZA-ROJO; E. LÓPEZ-BAYGHEN; A. ORTIZ-PLATA; 

P. AGUILERA. PERSONAL, Univ. Autonoma de Guerrero, 

Lab. de Biologia Mol. y Genomica, Univ. Autonoma de 

Guerrero, Ctr. de Investigación y Estudios Avanzados del 

IPN, Lab. de Neuropatologia Experiental, Inst. Nacional 

de Neurologia y Neurocirugia, Lab. de Patologia Vascular 

Cerebral, Inst. Nacional de Neurologia y Neurocirugia. 

3:00 Z12 466.23 S-allylcisteine regulates the N-methyl- 

D-aspartate receptor expression in a cerebral ischemia 

model. J. A. RIVERA RODRÍGUEZ*; P. AGUILERA; M. E. 

CHÁNEZ-CÁRDENAS; E. LÓPEZ-BAYGHEN; A. ORTIZ- 

PLATA; M. ESPINOZA-ROJO. Inst. Nacional de Neurología y 

Neurocirugía, Ctr. de Investigación y Estudios Avanzados del 

IPN, Univ. Autónoma de Guerrero. 

4:00 Z13 466.24 Dose response of recombinant tissue-type 

plasminogen activator (rt-PA) by carotid artery administration 

compared to external jugular vein administration in a 

mechanical model of ischemic stroke in the rat. R. C. 

CRUMRINE*; G. M. TAYLOR; J. C. LAMANNA; C. P. 

TSIPIS; V. J. MARDER; P. SCUDERI; V. ARORA. Talecris 

Biotherapeutics, Inc., Case Western Reserve Univ., David 

Geffen Sch. of Med. at UCLA. 

1:00 Z14 466.25 Triacsin C limits neurologic damage in 

the permanent and transient middle cerebral artery occlusion 

(MCAO) stroke models. A. MDZINARISHVILI*; U. BICKEL; X. 

CHEN; M. WEIS. Northeastern Ohio Univ., Texas Tech. Univ. 

POSTER 

467. Traumatic Brain Injury: Animal Models 



1:00 AA1 467.1 Rat model of brain injury caused by blastinduced 

hyper-acceleration. J. L. HAZELTON; G. FISKUM*; 

W. FOURNEY. Univ. Maryland Sch. Med., Univ. of Maryland 

Col. Park. 

2:00 AA2 467.2 A rodent model of blast-induced mild 

traumatic brain injury. K. L. BAALMAN*; R. J. COTTON; M. N. 

RASBAND. Baylor Col. of Med. 

3:00 AA3 467.3 Evaluation of sensorimotor behavioral 

tests for assessment of recovery after juvenile traumatic brain 

injury in a rodent model. K. L. RUSSELL*; N. E. J. BERMAN; 

B. LEVANT. Univ. of Kansas Med. Ctr. 

4:00 AA4 467.4 Craniotomy: True sham for traumatic 

brain injury or a sham of a sham. J. T. COLE*; A. YARNELL; 

W. S. KEAN; E. GOLD; B. LEWIS; M. REN; D. MCMULLEN; 

D. JACOBOWITZ; H. B. POLLARD; J. T. O’NEILL; N. 

GRUNBERG; C. L. DALGARD; J. A. FRANK; W. D. 

WATSON. Uniformed Services Univ., NIH. 



1:00 AA5 467.5 Repetitive concussive traumatic brain 

injury in mice causes multifocal axonal injury and persistent 

microglial reactivity. Y. SHITAKA*; H. T. TRAN; L. SANCHEZ; 

K. DIKRANIAN; D. L. BRODY. Astellas Pharma Inc, 

Washington Univ. 

2:00 AA6 467.6 Mechanical properties of the traumatically 

injured rodent brain determined with magnetic resonance 

elastography. M. L. KELSO*; E. T. CURTIS; S. F. OTHMAN. 

Univ. of Nebraska Med. Ctr., Univ. of Nebraska-Lincoln. 

3:00 AA7 467.7 Neurochemical profiles of blast 

induced traumatic brain injury in rat hippocampus and 

nucleus accumbens. S. V. SAJJA; F. GHODDOUSSI; P. 

VANDEVORD; M. P. GALLOWAY*. Wayne State Univ., 

Wayne State Univ. Sch. Med. 

4:00 AA8 467.8 A rat model of recurrent mild traumatic 

brain injury in opposite hemispheres. V. M. DONOVAN; J. 

S. COATS; A. OBENAUS; L. HUANG*. Univ. of California 

Riverside, Loma Linda Univ. 

1:00 AA9 467.9 Alterations in striatal dopamine synthesis 

and release at 1 day and 1 week after traumatic brain injury in 

rats. S. S. SHIN*; E. R. BRAY; C. Q. ZHANG; C. E. DIXON. 


2:00 AA10 467.10 Synaptic excitability in juvenile rat 

hippocampus after traumatic brain injury. A. ADAMI*; E. 

RUDOBECK; R. VLKOLINSKY; L. HUANG; A. OBENAUS. 

UC Riverside, Loma Linda Univ. 

3:00 AA11 467.11 Long-term motor dysfunctions and late 

emergence of cognitive deficits after traumatic brain injury 

in juvenile rats. D. O. AJAO*; J. E. KAMPER; V. POP; R. 

HARTMAN; A. OBENAUS; S. ASHWAL; J. BADAUT. Loma 

Linda Univ. 

4:00 AA12 467.12 Noninvasive topical agent loading for 

visual memri. S. SUN*; C. LUNDERVILLE; H. LIANG. Loma 

Linda Univ., Washington Univ. 

1:00 AA13 467.13 Connexin 43 and aquaporin 4: Partners 

in edema formation after juvenile traumatic brain injury. A. 

OBENAUS*; A. ADAMI; S. ASHWAL; J. BADAUT. Loma Linda 

Univ. 

2:00 AA14 467.14 Proteomic-based identification of injuryspecific 

patterns of biomarkers following different types of TBI. 

E. ROSTAMI*; A. GYORGY; J. DAVIDSSON; J. WALKER; 

D. WINGO; B. BELLANDER; D. AGOSTON; M. RISLING. 

Karolinska Inst., USU, Chalmers Univ. of Technol., Karolinska 

Univerisity Hospital, Solna. 

3:00 AA15 467.15 Serial MR imaging of recurrent mild 

traumatic brain injury in the rat. J. S. COATS*; K. J. 

NEGLERIO; A. MOHD-YUSOF; V. M. DONOVAN; Y. YIN; L. 

HUANG; A. OBENAUS. Loma Linda Univ., Univ. of California 

Riverside, California State University--San Bernadino. 

4:00 AA16 467.16 Differential acute gene expression 

changes after 5 types of traumatic injury in spinal cord and 

the brain. M. G. RISLING*; S. PLANTMAN; M. SKOLD; 

E. ROSTAMI; J. DAVIDSSON; B. BELLANDER; M. 

KIRKEGAARD; T. CARLSTEDT. Karolinska Inst., Chalmers 

technical university, Karolinska Hosp., Karolinska Institutet. 

1:00 AA17 467.17 Neuronal loss within the limbic system in a 

rat model of closed mild traumatic brain injury. D. L. MEYER*; 

D. DAVIES; J. L. BARR; P. MANZERRA; G. L. FORSTER. 

Univ. of South Dakota. 

2:00 AA18 467.18 Existing high blood glucose does not 

worsen outcome for moderately brain injured rodents. J. L. 

HILL*; J. ZHAO; P. DASH. Univ. of Texas, Houston. 



3:00 BB1 467.19 Traumatic brain injury impairs vagallymediated 

gastric motility. E. QUALLS-CREEKMORE; M. 

TONG; G. M. HOLMES*. Pennington Biomed Res. Ctr. 

4:00 BB2 467.20 Traumatic brain injury increases the 

number of migrating neuroblasts in the immature piglet. S. 

TAYLOR*; S. MISSIOS; M. K. SIMONI; T. A. RADWAN; B. A. 

COSTINE; C. P. DODGE; S. C. HILLIER; B. T. HARRIS; A. 

DUHAIME. Dartmouth Med. Sch., Dartmouth-Hitchcock Med. 

Ctr. 

1:00 BB3 467.21 Differential alterations of hippocampal 

GABA A receptor subunits following traumatic brain injury 

and posttraumatic epilepsy. E. A. KHARLAMOV*; E. 

LEPSVERIDZE; R. O. SOLOMONIA; E. R. MILLER; B. LU; T. 

M. HENTOSZ; K. M. KELLY; Z. MTCHEDLISHVILI. Allegheny- 

Singer Res. Institute, Allegheny Gen. Hosp., Drexel Univ. Col. 

of Med., Ilia Chavchavadze State Univ. 

2:00 BB4 467.22 LPS upregulates AQP4 in mouse cortical 

astrocytes via TLR4. D. KIMBLER*; C. ALLEYNE, Jr; K. 

DHANDAPANI. Med. Col. of GA. 

3:00 BB5 467.23 Traumatic brain injuries caused by 

mistreatment of dogs in the Roman Age. M. ZEDDA*; V. 

PETRUZZI; S. GADAU; G. LEPORE; E. MURA; F. BALZANO; 

A. MURA; V. FARINA. Univ. of Sassari, Dept. of Animal Biol., 

Univ. of Sassari, Vet. Pathology and Clin., Univ. of Padua, 

Dept. of Exptl. Vet. Sci. 

4:00 BB6 467.24 The effects of prior acute ethanol 

administration on functional sensorimotor recovery after 

traumatic brain injury. I. C. VAAGENES*; S. TSAI; V. A. 

HUSAK; C. M. PAPADOPOULOS; E. J. KOVACS; G. L. 

KARTJE. Loyola Univ. Chicago, Hines VA Hosp. 

1:00 BB7 467.25 GABA A -mediated [Ca 2+ ] i increase 

upregulates p75 NTR to trigger BDNF dependency in 

axotomized mature central neurons. A. SHULGA; A. 

MAGALHÃES; H. AUTIO; A. DI LIETO; A. NYKJÆR; U. 

ARUMÄE; E. CASTRÉN; C. RIVERA*. Univ. of Helsinki, 

Aarhus Univ. 

2:00 BB8 467.26 Blood-brain barrier disruption in 

collagenase-induced intracerebral hemorrhage in mice. T. 

WU*. Johns Hopkins Univ. 

3:00 BB9 467.27 An animal model of traumatic brain 

injury-induced anxiety: a possible role of neuroinflammation. 

K. M. RODGERS*; D. L. MCCALLUM; Y. K. DEMING; L. R. 

WATKINS; D. S. BARTH. Univ. Colorado. 

4:00 BB10 467.28 Blood brain barrier integrity and neuroimmune 

sequale after mild non-impact blast brain injury 

utilizing a new high-intensity focused ultrasound model. C. 

MORATZ; E. BURTON; G. WOODARD; J. DANQ; H. CHEN; 

J. LIU; C. BUDINICH; R. EGAN; Y. LIU; M. MYERS; J. T. 

MCCABE*. Dept of Medicine, Uniformed Servicies Univ. of the 

Hlth. Sci., Dept. of Medicine, Uniformed Services Univ., Dept. 

of Anatomy, Physiol. & Genetics, Uniformed Services Univ., 

FDA. 

1:00 BB11 467.29 • Xenopus as a model system for 

traumatic brain injury. C. R. MCKEOWN*; W. SHEN; H. T. 

CLINE. The Scripps Res. Inst. 

2:00 BB12 467.30 Repetitive mild closed head injury in the 

11-day-old rat: A model of inflicted brain trauma in infants. J. 

W. HUH*; R. PRASAD; D. FOX; R. RAGHUPATHI. Children’s 

Hosp. of Philadelphia, Drexel Univ. Col. of Med. 


Mon. PM

POSTER 

468. Spinal Cord Injury: human Studies and Animal Models 



1:00 BB13 468.1 • Fas/FasL mediated apoptosis and 

inflammation are key features of human and murine spinal 

cord injury: implications for translational, clinical application. 

W. YU*; M. G. FEHLINGS. Toronto Western Rsch institute, 

Toronto Western Res. Inst. and Krembil Neurosci. Centre,. 

2:00 BB14 468.2 Metabolic and endocrine changes 

following high- and low-thoracic spinal cord injury: 

Ramifications for reduced lifespan. W. T. PLUNET*; J. A. 

INSKIP; L. M. RAMER; W. TETZLAFF; A. V. KRASSIOUKOV; 

M. S. RAMER. Univ. of British Columbia. 

3:00 BB15 468.3 Limitations in correlating diffusion tensor 

imaging derived- and magnetization transfer derived-metrics 

with neurological function in subjects with spinal cord injury. 

V. BELEGU*; S. A. SMITH; A. GIFFORD; P. VAN ZIJL; J. W. 

MCDONALD. Hugo W. Moser Res. Inst. At Kennedy Krieger, 

Inc., Vanderbilt Univ. 

4:00 BB16 468.4 Brain motor control assessment sensitive 

measure for neurological classification of spinal cord injury. M. 

YAROSSI; E. GARBARINI; C. ANGELI; S. HARKEMA; G. F. 

FORREST*. Kessler Fndn. Res. Ctr., Univ. of Louisville, Univ. 

of Medcine and Dent. 

1:00 BB17 468.5 Cellular analysis of cerebrospinal fluid 

following acute human spinal cord injury. A. STAMMERS*; 

L. BELANGER; A. BERNARDO; D. CHAN; B. BRISSON; 

J. STREET; C. FISHER; M. BOYD; S. PAQUETTE; M. 

DVORAK; L. WEAVER; G. DEKABAN; B. KWON. Univ. 

British Columbia, Vancouver Spine Program, Univ. of British 

Columbia, Univ. of Western Ontario. 

2:00 BB18 468.6 Temporal changes in angiogenic proteins 

in cerebrospinal fluid after acute human spinal cord injury. 

M. T. L. NG*; A. T. STAMMERS; B. K. KWON. ICORD, Univ. 

of British Columbia, Dept. of Orthopaedics, Univ. of British 

Columbia. 

3:00 CC1 468.7 Axonal injury after partial spinal lesion 

in cats detected in vivo using diffusion tensor imaging. J. 

COHEN-ADAD*; H. LEBLOND; H. DELIVET-MONGRAIN; M. 

MARTINEZ; J. PROVENCHER; C. HURST; H. BENALI; S. 

ROSSIGNOL. MGH - Harvard Med. Sch., GRSNC, Univ. de 

Montreal, Unite de Neuroimagerie Fonctionnelle, CRIUGM, 

Univ. de Montreal, Lab. d’Imagerie Fonctionnelle, INSERM 

U678. 

4:00 CC2 468.8 Closed-loop isometric force control of the 

feline gastrocnemius muscle using interleaved intrafascicular 

multi-electrode stimulation. M. A. FRANKEL*; V. J. 

MATHEWS; S. G. MEEK; B. R. DOWDEN; G. A. CLARK; R. 

A. NORMANN. Univ. of Utah. 

1:00 CC3 468.9 Stimulation through Utah Slanted 

Electrode Arrays in monkey arm nerves recruits coordinated 

hand grasps. N. M. LEDBETTER*; C. ETHIER; E. R. OBY; 

A. M. WILDER; J. H. KO; S. AGNEW; L. E. MILLER; G. A. 

CLARK. Univ. of Utah, Northwestern Univ. 


2:00 CC4 468.10 Non-human primates show extensive 

functional recovery compared to rats after partial spinal cord 

injuries. L. F. FRIEDLI*; E. S. ROSENZWEIG; D. JINDRICH; 

S. C. STRAND; A. R. FERGUSON; P. MUSIENKO; R. R. 

ROY; H. ZHONG; M. S. BEATTIE; J. C. BRESNAHAN; M. 

H. TUSZYNSKI; V. R. EDGERTON; G. COURTINE. Dept. 

of Neurology, Univ. of Zurich, Dept. of Neurosciences, Univ. 

of California, Sch. of Life Sciences, Arizona State Univ., 

California Natl. Primate Res. Center, Univ. of California, Dept. 

of Neurosurgery, Univ. of California, Depts. of Physiological 

Sci. and Neurology, Univ. of California, VAMC. 

3:00 CC5 468.11 Assessment of conduction through motor 

pathways in the non human primate using clinically relevant 

methods: Normative data. D. F. TOVAR*; F. BENAVIDES; J. 

D. GUEST. Univ. Miami, Univ. of Miami. 

4:00 CC6 468.12 Role of motor pool recruitment and 

coordination in food-grasping and spring-pull tasks by Rhesus 

monkeys after a spinal hemisection. D. C. DUNBAR*; E. 

REJC; S. ZDUNOWSKI; A. SOTOLONGO; D. JINDRICH; 

R. R. ROY; H. ZHONG; G. COURTINE; J. LIU; T. BERNOT; 

R. MOSEANKO; M. TUSZYNSKI; V. R. EDGERTON. Univ. 

Puerto Rico Sch. Med., Univ. Udine, UCLA, Arizona State 

Univ., Univ. Zurich, UCD, UCSD. 

1:00 CC7 468.13 Myelin map after graded spinal cord injury 

in adult common marmosets. T. KONOMI*; K. FUJIYOSHI; 

K. HIKISHIMA; F. TOYODA; Y. TAKAHASHI; A. YASUDA; S. 

NORI; O. TSUJI; Y. TOYAMA; M. NAKAMURA; H. OKANO. 

Dept. of Orthopaedic Surgery, Keio University, Sch. of Med., 

Dept. of Physiology, Keio University, Sch. of Med., Central 

Inst. for Exptl. Animals. 

2:00 CC8 468.14 Histologic and behavioral outcomes in a 

porcine model of acute spinal cord injury. U. BURSTYN; E. B. 

OKON*; C. F. JONES; A. T. STAMMERS; P. S. KOONER; T. 

O. WONG; J. H. T. LEE; T. S. GODBEY; B. CHUA; G. GRAY; 

B. K. KWON. Univ. British Columbia, Univ. of British Columbia, 

Univ. of British columbia. 

3:00 CC9 468.15 Bladder voiding recovery time following 

mid-thoracic SCI in male rats is affected by the severity of 

damage to the lateral funiculus and proximity to the caudal 

thoracic spinal cord. S. L. FERRERO*; T. D. BRADY; V. 

P. DUGAN; C. H. HUBSCHER; R. D. JOHNSON. Univ. of 

Florida, Univ. of Louisville. 

4:00 CC10 468.16 Characterization of angiogenesis after 

spinal cord injury in mice. J. C. HSU*; J. LO; T. KO. Natl. 

Cheng-Kung Univ. Col. of Med., Taipei Med. Univ. 

1:00 CC11 468.17 A data-intensive, bioinformatic 

framework for translational spinal cord injury research. A. R. 

FERGUSON*; K. IRVINE; J. C. GENSEL; J. LY; A. LIN; J. C. 

BRESNAHAN; M. S. BEATTIE. UCSF Brain & Spinal Injury 

Cnt, The Ohio State Univ. 

2:00 CC12 468.18 Irvine, Beatties and Bresnahan (IBB) 

forelimb scale: A new method for assessing proximal 

and distal forelimb functional recovery following cervical 

spinal cord injury (SCI). K. A. IRVINE*; A. R. FERGUSON; 

S. B. BEATTIE; K. D. MITCHELL; M. S. BEATTIE; J. C. 

BRESNAHAN. Univ. of California, San Francisco. 

3:00 CC13 468.19 Visceral pain responses to bladder filling 

after a lumbosacral ventral root avulsion injury in the rat. L. A. 

HAVTON*; J. WU. UCLA. 

4:00 CC14 468.20 Characterization of experimental spinal 

cord injury caused by graded bilateral spine distraction. J. E. 

STEARNS*; B. B. ELMER; J. L. SEIFERT; D. SUCATO; M. 

I. ROMERO. Univ. of Texas At Arlington, Texas Scottish Rite 

Hosp. for Children. 



1:00 DD1 468.21 Protein expression and spontaneous 

recovery after incomplete spinal cord injury in the rat. J. 

V. LYNSKEY*; A. IARKOV; J. BURTON; Y. HATHOUT; S. 

KNOBLACH; C. AXMAN; C. KLATASKE; R. JUNG. A.T. Still 

Univ., Arizona State Univ., Children’s Natl. Med. Ctr. 

2:00 DD2 468.22 Novel anterograde transynaptic tracing 

identifies ascending sensory pathways after unilateral cervical 

spinal cord injury. M. R. DETLOFF*; R. E. WADE, Jr.; J. D. 

HOULÉ. Drexel Univ. Col. of Med. 

3:00 DD3 468.23 A novel contusive model of unilateral 

cervical spinal cord injury using the Infinite Horizon impactor. 

J. H. T. LEE; S. TIGCHELAAR; E. B. OKON; M. MALOON; J. 

LIU; A. M. T. STAMMERS; F. STREIJGER; W. TETZLAFF; B. 

K. KWON*. Univ. British Columbia. 

4:00 DD4 468.24 Chronic in vivo imaging of multiple 

constituents of the mouse spinal cord including a novel 

strategy for imaging myelin. M. J. FARRAR*; J. R. FETCHO; 

F. W. WISE; C. B. SCHAFFER. Cornell Univ. 

1:00 DD5 468.25 Vertebral landmarks for the identification 

of spinal cord segments in the mouse. G. SENGUL*; M. 

HARRISON; A. O’BRIEN; L. ADAMS; G. COWIN; M. 

RUITENBERG; C. WATSON. Ege Univ. Fac Med., The 

Univ. of Western Australia, The Univ. of Queensland, Ctr. for 

Advanced Imaging, The Univ. of Queensland, Sch. of Biomed. 

Sci., Prince of Wales Med. Res. Inst., Fac. of Hlth. Sciences, 

Curtin Univ. 

2:00 DD6 468.26 Expressed urine volumes during the acute 

phase following spinal cord injury predicts chronic functional 

outcome. P. J. WARD*; C. H. HUBSCHER. Dept. Anatom. Sci. 

and Neurobio., Univ. Louisville. 

3:00 DD7 468.27 Neurons in young rats respond differently 

to injury and therapeutic interventions from those in adults. 

M. MURRAY*; J. HOULE; K. OGATA; G. BARR. Drexel Univ. 

Col. Med., Drexel Univ. Col. of Med., Children’s Hosp. of 

Philadelphia. 

POSTER 

469. Spinal Cord Injury: Transplantation: Stem Cells and 

Embryonic Tissue 



1:00 DD8 469.1 Transplantation of human neural stem 

cells-derived oligodendrocyte precursor cells into contusive 

spinal cord injury in adult rats. K. HWANG*. Bk21 Project For 

Med. Sciences, Yonsei Univ. Col. of Med. 

2:00 DD9 469.2 Therapeutic potential of appropriately 

evaluated ‘safe’ induced pluripotent stem cells for spinal cord 

injury. O. TSUJI*; K. MIURA; Y. OKADA; K. FUJIYOSHI; M. 

MATSUMOTO; K. CHIBA; S. YAMANAKA; Y. TOYAMA; M. 

NAKAMURA; H. OKANO. Keio Univ., Kyoto Univ. 

3:00 DD10 469.3 Significance of re-myelination in the 

functional recovery after transplantation of NS/PCs into 

injured spinal cord. A. YASUDA*; O. TSUJI; K. FUJIYOSHI; 

S. SHIBATA; Y. KOBAYASHI; Y. TAKAHASHI; S. NORI; Y. 

TOYAMA; M. NAKAMURA; H. OKANO. Dept of Orthopaedics, 

Keio Univ, Sch. Med., Dept of Physiology, Keio Univ, Sch. 

Med. 



4:00 DD11 469.4 Epigenetic regulation of transplanted 

neural stem cells reconstructed injured spinal cord. M. 

ABEMATSU*; K. TSUJIMURA; M. YAMANO; M. SAITO; 

K. KOHNO; J. KOHYAMA; M. NAMIHIRA; S. KOMIYA; K. 

NAKASHIMA. Nara Inst. of Sci. and Technol., Grad. Sch. of 

Med. and Dent. Sciences, Kagoshima Univ., Osaka Prefecture 

Univ. 

1:00 DD12 469.5 Transplantation of human iPS cellderived 

neurospheres for the treatment of spinal cord injury 

in NOD-scid mice. S. NORI*; Y. OKADA; O. TSUJI; Y. 

TAKAHASHI; K. FUJIYOSHI; A. YASUDA; Y. KOBAYASHI; Y. 

TOYAMA; S. YAMANAKA; M. NAKAMURA; H. OKANO. Dept 

Orthopaedics, Keio Univ. Sch. Med., Dept Physiology, Keio 

Univ. Sch. Med., Kanrinmaru Project, Keio Univ. Sch. Med., 

Ctr. for iPS Cell Res. and Application(CiRA), Kyoto Univ. 

2:00 DD13 469.6 Transplantation of human embryonic 

stem cell derived-neural stem/progenitor cells for spinal cord 

injury in adult NOD/Scid mice. Y. TAKAHASHI*; Y. OKADA; 

G. KUMAGAI; O. TSUJI; S. NORI; A. YASUDA; Y. TOYAMA; 

H. OKANO; M. NAKAMURA. Keio Univ. Sch. Med., Hirosaki 


3:00 DD14 469.7 Transplantation of human neonatal cord 

blood stem cells into the injured spinal cord: Characterization 

of cell migration, axon regeneration, neurotrophic support 

and functional improvement. J. SCHIRA*; M. GASIS; V. 

ESTRADA; M. HENDRICKS; C. SCHMITZ; T. TRAPP; K. 

STUEHLER; G. KOEGLER; P. WERNET; H. W. MUELLER. 

Mol. Neurobio. Laboratory, Heinrich Heine Univ., Inst. for 

Transplantation Diagnostics and Cell Therapeutics, Heinrich 

Heine Univ., Med. Proteome Ctr. 

4:00 EE1 469.8 Respiratory changes following 

transplantation of post-natal neural precursors into high 

cervical hemilesions of the adult rat. M. S. SANDHU*; 

H. H. ROSS; B. J. DOUGHERTY; E. D. LAYWELL; B. K. 

ORMEROD; P. J. REIER; D. D. FULLER. Univ. Florida. 

1:00 EE2 469.9 Anatomical integration of transplanted 

neural tissue following cervical spinal cord injury and its effect 

on respiration in adult rat. M. A. LANE*; L. M. MERCIER; J. W. 

MEYER; F. L. HUNSAKER; D. E. SANCHEZ; D. F. RYCZEK; 

C. LOPEZ; B. E. O’STEEN; D. D. FULLER; P. J. REIER. Univ. 

Florida. 

2:00 EE3 469.10 Characterization of a rat upper cervical 

spinal cord injury model using chronic diaphragm EMG 

recordings: Potential for therapeutic cell transplantation 

strategies. M. P. HEFFERAN*; D. GOLDBERG; R. NAVARRO; 

M. MARSALA. Univ. California San Diego. 

3:00 EE4 469.11 Interaction between treadmill training 

exercise and transplanted neural stem cells following spinal 

cord injury. D. HWANG*; B. G. KIM; B. RYU. Ajou Univ., Ajou 

Univ. Sch. of Med., Chung-ang Univ. 

4:00 EE5 469.12 The use of human neural stem cells in 

spinal cord injury repair. P. JENDELOVA*; T. AMEMORI; N. 

KOZUBENKO; K. TURNOVCOVA; V. HERYNEK; J. PRICE; 

E. SYKOVA. Charles University, 2nd Med. Fac., Inst. of Exptl. 

Med. ASCR, Inst. for Clin. and Exptl. Med., Inst. of Psychiatry, 

Kings Col. 

1:00 EE6 469.13 Direct isolation and genome wide analysis 

of engrafted neural stem/precursor cells in injured spinal cord. 

H. KUMAMARU*; Y. OHKAWA; H. SAIWAI; K. KUBOTA; Y. 

IWAMOTO; S. OKADA. Dept. of Res. SSP Stem Cell Unit, 

Kyushu Univ., Dept. of Orthopaedics, Kyushu Univ. 


Mon. PM

2:00 EE7 469.14 Probing of molecular roles of human 

mesenchymal stromal stem cells in ameliorating the pathology 

of spinal cord injury. D. K. THAKOR*; D. BENEDICT; J. 

WANG; D. YU; Y. D. TENG. VA Boston Healthcare Syst., 


3:00 EE8 469.15 Proteolipid protein (PLP) and the 

pathophysiology of experimental spinal cord injury. J. WANG*; 

F. N. C. SANTOS; D. E. BENEDICT; D. YU; D. K. THAKOR; Y. 

D. TENG. Harvard Med. School/Brigham & Women’s Hospital, 

and Spaulding rehabilitaiton Hosp., VA Boston Healthcare 

Syst. 

4:00 EE9 469.16 Human neural stem cells restore 

function in the injured rat spinal cord via activation of local 

neurocircuitry. D. YU*; R. LANGER; Y. D. TENG. Harvard 

Med. Schl/BWH, VA Boston Healthcare Syst., Massachussetts 

Inst. of Technol., Harvard-MIT. 

1:00 EE10 469.17 Stem cell differentiation and SCI repair: 

The role of interneurons. Y. D. TENG*; D. YU; A. ROPPER; U. 

WILHELMSSON; M. PEKNY; R. ZAFONTE. Children’s Hosp/ 

Harvard Med. Sch., VA Boston Healthcare Syst., Spaulding 

Rehabil. Hosp., Brigham and Women’s Hosp., Univ. of 

Gothenburg. 

2:00 EE11 469.18 Stem cell therapy in conjunction with 

curcumin synergistically enhances recovery from spinal cord 

injury. D. R. ORMOND; K. DAS; R. ZEMAN; R. MURALI; M. 

JHANWAR-UNIYAL*. New York Med. Col., New York Med. 

Coll. 

POSTER 

470. Cell Death and Neurprotective Mechanisms: 

Apotosis and Caspases 



1:00 EE12 470.1 Neuroprotective kinase CK2 inhibits 

apoptosis via IP6K2 degradation. J. K. WERNER*, Jr.; A. 

CHAKRABORTY; M. A. KOLDOBSKIY; S. H. SNYDER. Johns 

Hopkins Univ. Sch. Med., Johns Hopkins Univ. Sch. of Med. 

2:00 EE13 470.2 Antiapoptotic effect of the dopamine 

D3 receptor agonist in malignant peripheral nerve sheath 

tumor cells. S. GIUNTA; A. CASTORINA; M. CARNAZZA; F. 

DRAGO; V. D’AGATA*. Univ. of Catania. 

3:00 EE14 470.3 Staurosporine and Trichostatine A induce 

apoptosis at the concentrations recommended to differentiate 

the RGC-5 cell line. S. O. SCHNICHELS*; M. SCHULTHEISS; 

K. MITEVA; K. WARSTAT; J. HOFMANN; P. SZURMAN; 

M. SPITZER; K. U. BARTZ-SCHMIDT; S. VAN LINTHOUT. 

Ctr. of Ophthalmology, Univ. Eye Hosp. Tuebingen, Berlin- 

Brandenburg Ctr. for Regenerative Therapies, Campus 

Virchow, Charité, University-Medicine Berlin, Berlin- 

Brandenburg Ctr. for Regenerative Therapies, Campus 

Virchow / Dept. of Cardiol. & Pneumology, Campus Benjamin 

Franklin, Charité, University-Medicine Berlin. 

4:00 EE15 470.4 Transcriptional cascades in cerebellar 

granule neurons following induction of apoptosis and rescue 

by different growth factors. S. PARATORE; M. CIOTTI; P. 

CALISSANO; S. CAVALLARO*. Italian Natl. Res. Council. 

1:00 EE16 470.5 Mevinphos induces cardiovascular 

responses and apoptosis by an action on amygdala. J. C. 

WU*; S. CHAN; A. CHANG. Ctr. For Translational Res. In 

Biomed. Sci., Natl. Sun Yat-sen Univ. 


2:00 EE17 470.6 Reduced neuronal degeneration 

after NFkB blockage in a model of sleep apnea by 

intermittent hypoxia. M. ANGELO; R. X. AVILES REYES; 

A. VILLARREAL; N. UNSAIN; P. A. BARKER; A. RAMOS*. 

IBCN, Facultad De Medicina, Univ. De Buenos Aires, Montreal 

Neurolog. Inst. 

3:00 EE18 470.7 Why are platin compounds effective 

anticancer drugs and (neuro-) toxins? A review on possible 

mechanisms of action. D. BUSSELBERG*; A. FLOREA. Weill 

Cornell Med. Col. In Qatar, Heinrich-Heine Univ. 

4:00 FF1 470.8 4,4’-diisothiocyanatostilbene-2,2’disulphonic 

acid (DIDS) is cytotoxic to neurons and 

astrocytes and does not protect against ischemic insult. M. 

E. PAMENTER; J. RYU; X. GU*; J. E. TJONG; G. PERKINS; 

J. E. MEERLOO; M. ELLISMAN; G. G. HADDAD. Univ. of 

California San Diego, The Rady Children’s Hosp. 

1:00 FF2 470.9 Differential apoptosis radiosensitivity of 

neural progenitors after ionizing radiation. Y. LI; F. G. LU*; C. 

WONG. Sunnybrook Hlth. Sci. Cen. 

2:00 FF3 470.10 Necrosis in rostral ventrolateral medulla 

mediates methamphetamine-induced fatal cardiovascular 

responses. F. C. LI*; S. H. H. CHAN; J. YEN; A. Y. W. 

CHANG. Dept. of Pharmacology, Natl. Yang-Ming Univ., Ctr. 

for Translational Res. in Biomed. Sciences, Chang Gung 

Mem. Hospital-Kaohsiung Med. Ctr. 

3:00 FF4 470.11 Epigallocatechin-3-gallate ameliorates 

alcohol-induced cognitive dysfunctions and apoptotic 

neurodegeneration in the developing rat brain. V. TIWARI*; A. 

KUHAD; K. CHOPRA. Panjab Univ. 

4:00 FF5 470.12 Nerve growth factor decreases ER stressinduced 

apoptosis through down-regulation of PUMA and 

Bim expression in PC12 cells. K. SHIMOKE*; S. KISHI; Y. 

NAKATANI; H. IRIFUNE; K. SUGIHARA; M. NOBUHARA; H. 

SASAYA; T. IKEUCHI. Kanasai Univ., Natl. Ctr. of Neurol. and 

Psychiatry (NCNP). 

1:00 FF6 470.13 The neuroprotective signaling 

mechanisms of telomerase via the induction by brain-derived 

neurotrophic factor in rat spinal cord motor neurons. C. NIU*; 

H. K. YIP. Dept. of Anatomy, The Univ. of Hong Kong. 

2:00 FF7 470.14 Neuroprotective effect of B23/NPM 

through regulation of Siah1 under DNA damage and oxidative 

stress condition. S. LEE*; J. AHN. Sungkyunkwan Univ. Sch. 

of Med. 

3:00 FF8 470.15 Dexmedetomidine protects against 

glucocorticoid induced neural progenitor cell apoptosis. K. K. 

NOGUCHI*; B. S. SWINEY; N. B. FARBER. Wahington Univ. 

St. Louis. 

4:00 FF9 470.16 Neuroprotective effect of black bean 

anthocyanins on β-amyloid (1-42) peptide- induced 

Alzheimer’s disease and aging model. M. KIM*; H. Y. LEE; I. 

ULLAH; M. S. PARK; M. O. KIM. Biology, Gyeongsang Univ. 

1:00 FF10 470.17 Sigma-2 receptor-mediated apoptosis and 

calcium signaling: Are they bifurcating pathways? D. GARCIA; 

W. D. BOWEN*. Brown Univ. 

2:00 FF11 470.18 FoxG1 promotes survival of postmitotic 

neurons. S. GHOSH DASTIDAR*; P. M. Z. LANDRIEU; S. R. 

D’MELLO. The Univ. of Texas At Dallas. 

3:00 FF12 470.19 Neuroprotection by complex formation of 

GAPDH/B23, inhibiting GAPDH/Siah1 induced apoptosis. J. 

PARK*; J. AHN. Dept. of Mol. Cell Biol., Ctr. for Mol. Medicine, 

Samsung Biomed. Res. Inst. 



4:00 FF13 470.20 Role of cathepsin D in U18666A-induced 

cell death in mouse primary hippocampal cultured neurons. 

A. AMRITRAJ*; D. VERGOTE; T. REVETT; M. SONG; D. 

WESTAWAY; S. KAR. Univ. of Alberta. 

1:00 FF14 470.21 Mediation by ERK and p38 of HSP70 

induction in preconditioning neuroprotection against apoptotic 

neuronal death. J. LEE; Y. KIM*; Y. KIM. Sejong Univ. 

2:00 FF15 470.22 Chronic swimming training affects 

glutamate release and caspase-3 expression in hippocampal 

slices submitted to oxygen and glucose deprivation. F. 

A. MOURÃO*; H. R. LEITTE; L. E. DRUMOND; D. C. 

MEDEIROS; I. L. L. ANDRADE; G. S. PEREIRA; M. F. D. 

MORAES; A. R. MASSENSINI. Univ. Federal De Minas 

Gerais, Ctr. Universitário de Belo Horizonte UNI-BH. 

3:00 FF16 470.23 Neuroprotective effect of anthocyanins link 

via GABA B receptor on β-amyloid (25-35)-mediated neuronal 

apoptosis in vitro system. L. HAE YOUNG*; J. S. HWANG; J. 

M. LEE; S. E. KIM; M. O. KIM. Gyeongsang Natl. Univ. 

4:00 FF17 470.24 Protein S protects neurons against tissue 

plasminogen activator/N-methyl D-aspartate toxicity. T. M. 

BARRETT*; H. GUO; B. V. ZLOKOVIC. Univ. of Rochester. 

POSTER 

471. Genetic Models with Schizophrenia Risk Genes 



1:00 FF18 471.1 Mice heterozygous for the netrin-1 

receptor DCC exhibit alterations in mesocortical dopamine 

synaptic connectivity. C. MANITT*; A. MIMEE; C. ENG; C. 

FLORES. Douglas Mental Hlth. Univ. Institute, McGill Univ. 

2:00 FF19 471.2 Mutant DISC1 attenuates 

methamphetamine-induced behavioral neuroplasticity in a 

sex-dependent manner. V. M. POGORELOV*; A. KAMIYA; I. 

KRASNOVA; G. I. ELMER; J. L. CADET; M. V. PLETNIKOV. 

Johns Hopkins Univ. Sch. of Med., Natl. Inst. of Health, NIDA, 

MPRC Sch. of Med. 

3:00 FF20 471.3 In vivo and in vitro analysis of a 

schizophrenia candidate gene Rapgef6. R. J. LEVY*; M. 

KVAJO; M. KARAYIORGOU; J. A. GOGOS. Columbia Univ., 

New York State Psychiatric Inst. 

4:00 GG1 471.4 • NMDAR1 heterozygous knockdown 

mice exhibit features of psychiatric disorders. J. H. KOGAN*; 

R. SHIN; N. M. WALTON; C. L. HEUSNER; Q. CHEN; K. 

TAJINDA; J. N. MASTERS; K. TAMURA; M. MATSUMOTO. 

Astellas Res. Inst. of America LLC. 

1:00 GG2 471.5 Differentiation of oligodendrocytes and 

neuregulin signaling are affected in mutant human DISC1 

mice. P. L. KATSEL*; W. TAN; B. ABAZYAN; K. DAVIS; C. 

ROSS; M. PLETNIKOV; V. HAROUTUNIAN. Mount Sinai 

Med. Ctr., Johns Hopkins Univ. 

2:00 GG3 471.6 Intramembranous valine linked to 

schizophrenia is required for Type III neuregulin 1 signaling 

in cortex. Y. CHEN*; M. L. HANCOCK; L. W. ROLE; D. A. 

TALMAGE. SUNY At Stony Brook, Harvard Med. Sch., SUNY 

at Stony Brook. 

3:00 GG4 471.7 Generation of humanized comt met/val 

mouse lines. X. ZHOU*; V. RISBROUGH. UCSD. 



4:00 GG5 471.8 • Adult neurogenesis deficits in the dentate 

gyrus of SREB2/GPR85 transgenic mice are associated with 

features of psychiatric disorders. Q. CHEN*; J. H. KOGAN; 

N. M. WALTON; R. SHIN; C. L. HEUSNER; K. TAJINDA; J. 

N. MASTERS; K. TAMURA; M. MATSUMOTO. CNS, Astellas 

Res. Inst. of America LLC. 

1:00 GG6 471.9 Behavioral phenotype comparison 

of NMDAR1 homozygous and heterozygous knockdown 

mice. K. HARADA; M. SHOBO; M. MORITA; T. MIHARA; 

H. YAMADA; Y. KONDO; M. AOTA; K. NI; N. MATSUOKA*. 

Astellas Pharma Inc. 

2:00 GG7 471.10 Distinct presynaptic effects of disruptedin-schizophrenia 

(DISC1) and a c-terminal deletion mutant 

(DISC1ΔC) on neocortical synapses. B. J. MAHER*; J. J. 

LOTURCO. Univ. Connecticut, Univ. of Connecticut. 

3:00 GG8 471.11 Deletion of CB 2 cannabinoid receptor 

induces schizophrenia-related behaviours in mice. A. 

ORTEGA-ALVARO*; A. ARACIL-FERNÁNDEZ; M. GARCÍA- 

GUTIÉRREZ; F. NAVARRETE; J. MANZANARES. Unidad 

De Neuropsicofarmacologia. CHUA., Inst. de Neurociencias. 

Univ. Miguel Hernández-CSIC. 

4:00 GG9 471.12 Aberrant assembly and function 

of a hippocampal circuit in a genetic mouse model of 

schizophrenia. H. MCKELLAR*; M. KVAJO; L. J. DREW; 

A. LEPAGNOL-BESTEL; L. XIAO; P. ARGUELLO; C. O. 

LACEFIELD; M. SIMONNEAU; J. M. O’DONNELL; A. 

B. MACDERMOTT; M. KARAYIORGOU; J. A. GOGOS. 

Columbia Univ., Faculté de Médecine Xavier Bichat, West 

Virginia Univ. Hlth. Sci. Ctr., New York State Psychiatric Inst. 

1:00 GG10 471.13 Enhanced perseverative behaviors in 

mice lacking the eIF2α kinase PERK: links to schizophrenia. 

M. A. TRINH*; H. KAPHZAN; S. VAN DRIESCHE; K. 

COWANSAGE; D. R. CAVENER; J. C. DARNELL; E. KLANN. 

New York Univ., Rockefeller Univ., Penn State Univ. 

2:00 GG11 471.14 Cortical synaptic GABA deficits in 

mice with insufficient expression of full-length disc1. S. 

M. HOLLEY*; S. SINGH; E. WANG; C. CEPEDA; J. D. 

JENTSCH; M. S. LEVINE. UCLA. 

3:00 GG12 471.15 Histological and behavioral analysis of 

telencephalon-spesific Dab1-deficient mouse. I. HIDEAKI*; 

A. TAKANO; N. RYOYAMA; K. SAKIMURA; K. SUGIOKA; 

T. TERASHIMA; Y. KATSUYAMA. Kobe Univ. Grad. Sch. of 

Med., Niigata University, Brain Res. Inst., Himeji Dokkyo Univ. 

4:00 GG13 471.16 Analysis of DISC1 using knockout mice 

and new antibodies. K. KURODA; D. MORI; T. NAMBA; 

D. TSUBOI; H. YANO; D. IBI; M. TANAKA; M. ISOTANI; A. 

ENOMOTO; K. YAMADA; M. SOKABE; M. TAKAHASHI; K. 

KAIBUCHI*. Nagoya Univ. Glad. Sch. Med., JST, CREST. 

1:00 GG14 471.17 Zic2 hypomorphic mutant mice exhibit 

cognitive impairment and social behavior abnormalities with 

an altered distribution of basal forebrain cholinergic neurons. 

J. ARUGA*; M. HATAYAMA; N. TAKASHIMA; K. SAKOORI; Y. 

NOZAKI; Y. S. ODAKA; K. YAMADA; A. ISHIGURO. RIKEN 

BSI. 

2:00 GG15 471.18 Densin-180 knockout mice display 

schizophrenia-like behaviors and have reduced levels of 

metabotropic glutamate receptors in the postsynaptic density. 

H. J. CARLISLE*; T. LUONG; A. MEDINA-MARINO; K. 

M. GUNAPALA; A. D. STEELE; P. H. PATTERSON; M. B. 

KENNEDY. Caltech. 

3:00 GG16 471.19 Disruption of Neuregulin-1 gene affects 

working memory ability in adult rats. A. R. TAYLOR*; S. B. 

TAYLOR; J. I. KOENIG. Maryland Psychiatric Res. Ctr. Univ. 

of Maryland, Baltimore. 


Mon. PM

4:00 HH1 471.20 Abnormal behavioral phenotypes during 

development in Grin1 mutant mice. S. S. MOY*; R. J. 

NONNEMAN; G. O. SCHAFER; L. K. BAKER; J. M. NUNEZ; 

V. D. NIKOLOVA; B. H. KOLLER; G. E. DUNCAN. Univ. NC 

Sch. Med. 

1:00 HH2 471.21 • Disruption of disrupted-inschizophrenia-1 

function both in adult newborn neurons and 

adult inducible transgenic mice results in schizophreniarelated 

phenotypes . W. LI*; M. ZHOU; X. TIAN; J. KIM; T. 

CANNON; G. MING; H. SONG; A. J. SILVA. Shanghai Jiao 

Tong Univ., UCLA, Johns Hopkins Univ. Sch. of Med. 

2:00 HH3 471.22 Behavioral characterization of 14-3-3 

functional knock-out mice. M. M. FOOTE*; K. GRAHAM; H. LI; 

Y. WU; Y. ZHOU. Florida State Univ. 

3:00 HH4 471.23 ErbB4 in parvalbumin-positive 

interneurons is critical for neuregulin 1 regulation of long-term 

potentiation and contextual fear conditioning. Y. CHEN*; M. 

ZHANG; D. YIN; L. WEN; C. LAI; A. TING; P. WANG; Y. LU; 

X. ZHU; S. LI; C. WU; X. WANG; W. XIONG; L. MEI; T. GAO. 

IMMAG, Southern Med. University,, Gill Ctr. for Biomolecular 

Sci. 

4:00 HH5 471.24 Generation of neuronal progenitor cell 

models from transgenic mice with regulated human mutant 

DISC1 expression. S. S. AKIMOV; E. CHIGHLADZE; B. 

ABAZYAN; M. V. PLETNIKOV; C. A. ROSS*. Johns Hopkins 

Med. Sch. 

1:00 HH6 471.25 ErbB4 in amygdala is critical for cued fear 

conditioning. Y. LU*; D. YIN; Y. CHEN; L. WEN; W. XIONG; L. 

MEI. Med. Col. of Georgia. 

2:00 HH7 471.26 Shudderer, a dominant mutation in 

Drosophila causing lithium-responsive neurological defects, 

is allelic to the voltage-gated sodium channel gene paralytic. 

G. A. KAAS*; R. JEWELL; J. KASUYA; T. KITAMOTO. Univ. 

Iowa, Univ. of Iowa. 

3:00 HH8 471.27 Cellular mechanisms underlying 

decreases in glutamate release in dysbindin deficient mice. W. 

B. GLEN; A. L. GRIGG; A. LAVIN*. Med. Univ. South Carolina. 

4:00 HH9 471.28 Effects of Nrg/ErbB4 signaling on 

glutamatergic transmission onto inhibitory interneurons. D. 

VULLHORST*; C. M. GONZALEZ; C. COLINA; J. NEDDENS; 

A. BUONANNO. NICHD, NIH. 

1:00 HH10 471.29 Interaction between prenatal stress and 

genetic factors modulates schizophrenic endophenotypes in 

the Snap-25 mouse mutant blind-drunk. P. L. OLIVER*; K. E. 

DAVIES. MRC Functional Genomics Unit. 

2:00 HH11 471.30 Downregulation of D1 modulation of cell 

excitability in prefrontal pyramidal neurons in slices from val/ 

val COMT mice. F. HUPPE-GOURGUES*; F. PAPALEO; 

C. JINGSHAN; D. WEINBERGER; P. O’DONNELL. Univ. 

Maryland Sch. of Med., NIMH. 

POSTER 

472. Novel Pharmacologic Approaches in Psychotic 

Diagnoses 



1:00 HH12 472.1 • Gamma oscillations, delayed auditory 

evoked responses: Translational biomarkers of autism. M. 

J. GANDAL*; M. MEHTA; J. C. EDGAR; T. P. ROBERTS; 

S. J. SIEGEL. Univ. of Pennsylvania, Childrens Hosp. of 

Philadelphia. 


2:00 HH13 472.2 Adjuvant activity of the novel sodium 

channel blocker NW-3509 in combination therapy with 

antipsychotics. E. IZZO*, Dr; A. IERACI; S. MELI; P. SALVATI; 

M. BORTOLATO; R. FRAU; V. BINI; R. ANAND. Newron 

Pharmaceuticals SpA, Univ. of Cagliari, APC, AG. 

3:00 HH14 472.3 NMDA antagonist disruptions of gamma 

synchrony as a translational model for novel therapeutics. 

J. SAUNDERS*; M. J. GANDAL; S. J. SIEGEL. Univ. of 

Pennsylvania. 

4:00 HH15 472.4 In vivo characterization of a potent, 

selective KATII inhibitor as a regulator of kynureninic acid 

production in rat brain: A microdialysis study in freely moving 

rats. W. HORNER; R. R. GORCZYCA*; Z. HUGHES; B. 

CAMPBELL; K. FONSECA; P. VERHOEST. Pfizer Global 

Res. & Dev. 

1:00 HH16 472.5 • Central receptor occupancy and 

pharmacodynamic action of PF-04455242, a high affinity, 

selective kappa opioid receptor antagonist, in humans. L. K. 

JACOBSEN*; A. BANERJEE; W. BYON; H. Y. HUANG; R. 

E. CARSON; G. TOMASI; D. WEINZIMMER; W. WILLIAMS; 

S. LIN; J. ROPCHAN; T. J. MCCARTHY; S. GRIMWOOD; L. 

BADURA. Pfizer Global Res. and Develop., Yale PET Ctr. 

2:00 HH17 472.6 Cognitive impairment and catalepsy in 

the absence of positive symptoms with chronic amphetamine 

administration in mice. R. LIN*; Y. LIANG; J. SUH; S. J. 

SIEGEL. Univ. of Pennsylvania, Johns Hopkins Univ. 

3:00 HH18 472.7 • Identification and characterization 

of a potent, selective KATII inhibitor. C. A. STRICK*; B. 

CAMPBELL; J. S. CULP; K. R. FONSECA; S. J. HAWRYLIK; 

M. M. HAYWARD; W. E. HORNER; L. C. JAMES; P. 

LOULAKIS; D. MCGINNIS; M. A. SALAFIA; P. A. SEYMOUR; 

B. SNEED; N. C. STRATMAN; K. J. STUTZMAN-ENGWALL; 

J. J. VALENTINE; P. R. VERHOEST; H. WANG; L. E. 

ZAWADZKE; H. ZHAO. Neurosci. Res. Unit, Pfizer Inc. 

4:00 HH19 472.8 PD149163, a neurotensin-1 receptor 

agonist, infusion into the ventral pallidum attenuates prepulse 

inhibition deficits in Brown Norway rats. P. D. SHILLING*; G. 

MELENDEZ; D. FEIFEL. UCSD. 

1:00 HH20 472.9 • Comparative anatomical distribution of 

kappa opioid receptors in human, guinea pig, and rodent 

brains. F. BIAN*; D. HANNAH; B. CAMPBELL. Pfizer 

PharmaTherapeutics. 

2:00 II1 472.10 • Neurochemical characterization of the 

pharmacological inhibition of kynurenine aminotransferases 

in the rat medial prefrontal cortex. R. M. HINCHLIFFE; R. 

PACHMERHIWALA; A. Y. KORNILOVA; H. A. RAJAPAKSE; 

M. W. EMBREY; S. RITTLE; J. A. MCCAULEY; I. J. 

REYNOLDS; W. J. RAY; S. M. SMITH*. Merck & Co., Inc. 

3:00 II2 472.11 NMDA Receptor-1 hypomorphic 

affect on GABAergic interneurons subpopulations. V. M. 

TATARD LEITMAN*; M. J. GANDAL; S. J. SIEGEL. Univ. of 

Pennsylvania. 

4:00 II3 472.12 Pharmacokinetic characterization of 

EVX001650, a potent and selective PDE10A inhibitor. H. 

E. HODGDON*; Z. YANG; D. COSTA; D. SPAULDING; S. 

NOLAN; M. WEN; A. RIPKA; G. SHAPIRO; R. CHESWORTH; 

L. LEVENTHAL; K. ROGERS. Envivo Pharmaceuticals. 

1:00 II4 472.13 ZM 241385, a selective antagonist of 

adenosine-2A receptors, potentiates the effect of haloperidol 

on dopamine neurotransmission in vivo. E. DREMENCOV*; 

J. H. A. FOLGERING; G. FLIK; T. I. F. H. CREMERS; B. H. C. 

WESTERINK. Brains On-Line BV, Brains On-Line US LLC, 

Univ. of Groningen. 



2:00 II5 472.14 PAK1 inhibitors rescue DISC1 deficitmediated 

dendritic spine deterioration: Implications for a 

novel therapeutic strategy for schizophrenia? A. HAYASHI*; Y. 

ARAKI; B. VOLLRATH; S. DURON; Z. YAN; R. L. HUGANIR; 

D. CAMPBELL; A. SAWA. Johns Hopkins Univ., Afraxis, Inc, 

Univ. at Buffalo, SUNY. 

3:00 II6 472.15 • Comparing structurally diverse PDE10 

inhibitors in condition avoidance, catalepsy and enzyme in 

vivo binding in rats. B. STEINIGER BRACH*; L. TØTTRUP 

BRENNUM. H Lundbeck A/S. 

4:00 II7 472.16 • The impact of a KATII inhibitor on 

performance in the rat sustained attentional task (SAT) and 

conditioned avoidance responding (CAR). D. S. CHAPIN*; 

B. CAMPBELL; C. STRICK; R. KOZAK. Pfizer Global Res. & 

Dev, Pfizer Inc. 

1:00 II8 472.17 The effects of the phosphodiesterase 10A 

inhibitor, TP-10, on antipsychotic efficacy in preclinical models 

of antipsychotic activity. V. GUANOWSKY*; D. S. CHAPIN; C. 

J. SCHMIDT; F. S. MENNITI; P. A. SEYMOUR. Pfizer Global 

Res. & Dev. 

2:00 II9 472.18 • Inhibition of kynurenine aminotransferase 

ii (kat ii) protects against ketamine-induced cognitive 

impairment and improves spatial working memory. A. 

ABBOTT; B. M. ROBERTS; L. TURNER; D. W. CAMPBELL; 

C. L. SCHAFFER; B. M. CAMPBELL*; P. A. SEYMOUR; C. J. 

SCHMIDT; G. V. WILLIAMS; S. A. CASTNER. Yale Univ. Sch. 

of Med., VA Connecticut Healthcare Syst., Pfizer Corp. 

3:00 II10 472.19 • The effects of a selective 

phosphodiesterase 10A inhibitor on prepulse inhibition in rats. 

V. B. RISBROUGH; C. J. SCHMIDT; P. A. SEYMOUR*; J. E. 

GRESACK. UCSD, Veterans Affairs Ctr. of Excellence for 

Stress and Mental Hlth., Pfizer Global Res. & Dev. 

4:00 II11 472.20 • Pharmacological characterization of PF- 

04455242, a high affinity, selective antagonist for kappa opioid 

receptors. A. W. SCHMIDT*; M. A. VANASE-FRAWLEY; 

M. COLLINS; S. MCLEAN; J. FREEMAN; S. WONG; J. 

MCLAUGHLIN; P. VERHOEST; S. GRIMWOOD. Pfizer Global 

Res. & Dev, Pfizer Inc, Northeastern Univ. 

1:00 II12 472.21 Pharmacological characterization of 

EVX001650, a potent and selective PDE10A inhibitor for 

treatment of schizophrenia. S. C. HOPP*; M. MILLER; 

Z. YANG; G. SHAPIRO; R. CHESWORTH; A. RIPKA; K. 

ROGERS; L. LEVENTHAL. Envivo Pharmaceuticals. 

2:00 II13 472.22 Effects of ketamine in rodent 

tests for antidepressant efficacy and cognition. R. E. 

FEATHERSTONE*; I. LUCKI; S. J. SIEGEL. Univ. of 

Pennsylvania. 

3:00 II14 472.23 Preclinical receptor occupancy and 

spiradoline-induced plasma prolactin as potential translatable 

biomarkers for the kappa opioid receptor antagonist PF- 

04455242. S. GRIMWOOD*; S. WONG; S. MCLEAN; Y. LU. 

Pfizer Inc. 

4:00 II15 472.24 • Common cellular networks affected by 

DAAO, GlyT1 and KATII inhibitors as revealed by expression 

profiling. P. ZAGOURAS*; S. G. DES ETAGES; L. S. HAYES; 

B. CAMPBELL; L. C. JAMES; C. A. STRICK. Pfizer. 



1:00 II16 472.25 • Receptor occupancy data in healthy 

volunteers for ITI-007, an investigational new drug for 

the treatment of schizophrenia, insomnia, and other 

neuropsychiatric disorders. D. F. WONG*; Y. ZHOU; M. 

GUEVARA; J. BRASIC; W. YE; V. RAYMONT; W. WILLIS; G. 

SNYDER; J. HENDRICK; A. FIENBERG; L. WENNOGLE; S. 

MATES; R. DAVIS; K. VANOVER. Johns Hopkins Med. Insts., 

Intracellular Therapies, Inc., 3-D Pharmaceut. Consultants, 

Inc. 

POSTER 

473. Alcohol: Neural Mechanisms 



1:00 II17 473.1 Acute and chronic effects of ethanol on 

complex spike synchrony patterns. A. SALAH*; E. J. LANG. 

NYU Sch. of Med. 

2:00 II18 473.2 cAMP-dependent long-lasting ethanol 

potentiation of GABAergic synaptic transmission modulated 

by 5-HT 3 receptors in mechanically isolated hippocampal CA1 

neurons. S. JUN*; S. IKEDA; D. M. LOVINGER. NIH/NIAAA. 

3:00 II19 473.3 Binge alcohol exposure transiently 

increases the number of rat brain α7 and non-α7 neuronal 

nicotinic receptors. K. LUKING; K. NIXON; D. HOPKINS; J. R. 

PAULY*. Univ. of Kentucky. 

4:00 II20 473.4 Ethanol exposure enhances the sodium/ 

calcium exchanger currents in inferior colliculus neurons. 

P. N’GOUEMO*; D. M. LOVINGER. Georgetown Med. Ctr., 

NIAAA. 

1:00 JJ1 473.5 The role of microRNAs in ethanol 

responses: a systems genetics analysis of the processing 

gene Drosha. L. LU; J. YUE; Y. CUI; R. W. WILLIAMS; K. M. 

HAMRE*. Univ. Tennessee Hlth. Sci. Ctr. 

2:00 JJ2 473.6 Ethanol-sensitive ENT1 regulates striatal 

glutamate signaling through the PKCΓ-neurogranin-CaMKII 

pathway. H. NAM*; M. R. LEE; Y. ZHU; J. WU; D. J. HINTON; 

S. CHOI; T. KIM; J. C. P. YIN; D. CHOI. Mayo Clin. Col. of 

Med., Univ. of Wisconsin. 

3:00 JJ3 473.7 Ethanol impairs NMDA receptor function in 

cerebellar Purkinje cells. Q. HE*; C. PIOCHON; C. HANSEL. 

Univ. of Chicago, Univ. of chicago. 

4:00 JJ4 473.8 � Neonatal exposure to alcohol alters 

spinal cord innervation. E. ROBINSON; G. GURAM; A. D. 

MCKELVY; S. M. SWEITZER*. Univ. South Carolina Sch. 

Med. 

1:00 JJ5 473.9 Morphological analysis of dendrites 

and dendritic spines of medium spiny neurons in a mouse 

model of binge-like ethanol drinking. G. M. SPROW*; N. A. 

SHERAZEE; P. F. KRAMER; T. E. THIELE; V. A. ALVAREZ. 

Univ. North Carolina, NIH. 

2:00 JJ6 473.10 Striatal enriched protein tyrosine 

phosphatase and p38 mitogen-activated protein kinase 

regulate NMDA receptor responses to acute ethanol 

in hippocampal brain slices. W. R. PROCTOR*; S. J. 

COULTRAP; M. D. BROWNING; P. H. WU. VA ECHCS & 

Univ. Colo Denver, Univ. of Colorado Denver. 

3:00 JJ7 473.11 Proteomic analysis of the mouse 

amygdala following voluntary alcohol consumption. M. C. 

SALLING*; S. P. FACCIDOMO; C. HODGE. UNC Sch. of 

Med. 


Mon. PM

4:00 JJ8 473.12 Effects of acute and chronic intermittent 

ethanol exposure on neuron excitability in the orbitofrontal 

cortexv. K. A. BADANICH*; H. C. BECKER; J. J. 

WOODWARD. Med. Univ. of South Carolina. 

1:00 JJ9 473.13 Gene expression profiling analysis 

involved in alcohol and naltrexone responses in murine 

hippocampus and prefrontal cortex. K. JUNG; D. HALDER; 

N. DAS; M. BAEK; J. PARK; H. LEE; M. CHOI; K. PARK; Y. 

CHAI*. Hanyang Univ. 

2:00 JJ10 473.14 Presynaptic munc 13.1, a molecular target 

of alcohol? S. PANY*; J. DAS. Univ. of Hosuton, Univ. of 

Houston. 

3:00 JJ11 473.15 Arf6 defines an inebriation pathway in 

the adult drosophila central nervous system. R. L. PERU*; A. 

RODAN; A. ROTHENFLUH. Univ. of Texas at Southwestern 

Med. Ctr. at Dallas. 

4:00 JJ12 473.16 Discrete excitation and inhibition of VTA 

neurons by ethanol in freely moving rats. W. M. DOYON*; W. 

LI; J. A. DANI. Baylor Col. Med. 

1:00 JJ13 473.17 Phasic firing patterns of dorsal striatal 

neurons at cue presentations during variable and fixed 

operant schedules of alcohol reinforcement. R. M. REESE; 

R. R. FANELLI; D. L. ZITZMAN; D. L. ROBINSON*. Univ. of 

North Carolina, Chapel Hill. 

2:00 JJ14 473.18 Ethanol administration alters AMPAR 

activity in dopamine D1 receptor-expressing medium spiny 

neurons of the dorsal striatum. J. WANG*; D. RON. Gallo Res. 

Ctr., Univ. of California San Francisco. 

3:00 JJ15 473.19 • Long-term depression of GABAergic 

synapses on GABA neurons after a single ethanol exposure. 

R. S. WILCOX; B. R. LARSEN; S. S. SANDOVAL; D. W. 

ALLISON; S. C. STEFFENSEN*. Brigham Young Univ. 

4:00 JJ16 473.20 Effect of ethanol on the expression of 

brain-derived neurotrophic factor in the rat brain. N. RAIVIO*; 

E. TIRABOSCHI; S. T. SAARIKOSKI; E. CASTRÉN; K. 

KIIANMAA. Natl. Inst. for Hlth. and Welfare, Univ. of Helsinki, 

Neurosci. Ctr., Univ. of Helsinki, Inst. of Biomedicine. 

1:00 KK1 473.21 • The role of connexin-36 gap junctions 

between GABA neurons in the ventral tegmental area in 

alcohol intoxication and reward. D. HANSEN*; B. S. HOYT; R. 

S. WILCOX; J. D. WILCOX; C. B. MERRILL; D. W. ALLISON; 

J. G. EDWARDS; S. C. STEFFENSEN. Brigham Young Univ. 

2:00 KK2 473.22 Impact of short-term ethanol exposure in 

the proliferation of ganglionic eminence progenitors. R. A. S. 

CRUZ; J. M. LIMA; E. N. YAMASAKI; D. UZIEL*. Univ. Fed Do 

Rio de Janeiro, Univ. of Nicosia. 

3:00 KK3 473.23 Glucocorticoid receptors play an important 

role in yohimbine-induced reinstatement of ethanol-seeking. J. 

A. SIMMS*; C. L. HAASS-KOFFLER; J. K. RICHARDS; I. C. 

KANHOLM; J. Y. HOLGATE; S. E. BARTLETT. Ernest Gallo 

Clin., Univ. of California San Francisco. 

4:00 KK4 473.24 Neurotensin receptor type 2 regulates 

hypnotic ethanol sensitivity and ethanol consumption in mice. 

M. R. LEE*; D. J. HINTON; S. S. UNAL; E. RICHELSON; D. 

CHOI. Mayo Clin. Col. Med. 

1:00 KK5 473.25 Ras suppressor-1 implicates the integrin 

signaling pathway in regulating alcohol induced behaviors. 

S. A. OJELADE*; A. ROTHENFLUH. Univ. of Texas- 

Southwestern. 


2:00 KK6 473.26 Alcohol-heightened aggression in mice: 

Opposing effects of CRF1 vs. CRF2 receptors in the dorsal 

raphé and interactions with serotonin. I. M. QUADROS*; L. 

HWA; T. M. MIGUEL; A. SHIMAMOTO; J. F. DEBOLD; K. A. 

MICZEK. Tufts Univ. 

3:00 KK7 473.27 Pharmacokinetics of nicotine and its 

metabolite cotinine in the brain of alcohol-preferring (P) rats 

following subcutaneous administration as measured by in 

vivo microdialysis coupled with HPLC-UV detection. S. N. 

KATNER*; J. E. TOALSTON; J. A. MCCLAREN; C. D. BARD; 

E. A. ENGLEMAN; Z. A. RODD; W. J. MCBRIDE. Indiana 


POSTER 

474. Alcohol: Developmental Adolescence 



1:00 KK8 474.1 Adolescent binge-drinking alters the 

central circuits known to regulate the stress response. C. D. 

ALLEN*; S. Y. LEE; G. F. KOOB; C. L. RIVIER. The Salk Inst. 

For Biol. Studies, The Scripps Res. Inst. 

2:00 KK9 474.2 Reward processing in adolescents at high 

risk for alcoholism. A. CSERVENKA*; B. J. NAGEL. Oregon 

Hlth. & Sci. Univ. 

3:00 KK10 474.3 Long-term effects of adolescent 

alcohol exposure on five-choice serial reaction time task, 

operant alcohol self-administration, and radial arm maze 

performance in Wistar rats. J. A. WOUDA; T. PATTIJ; A. N. 

M. SCHOFFELMEER; A. B. SMIT; T. J. DE VRIES*. NCA 

Vu&Vumc. 

4:00 KK11 474.4 Epigenetic modulation by acute ethanol 

exposure in mPFC of adolescent rats. N. N. NEW*; K. J. 

HERRICK; P. J. MULHOLLAND; L. J. CHANDLER. MUSC. 

1:00 KK12 474.5 Differential effect of alcohol on 

phosphorylated histone H3 in adolescent dentate gyrus. J. A. 

MCCLAIN*; S. A. MORRIS; K. NIXON. Univ. of Kentucky. 

2:00 KK13 474.6 Effects of early life stress and chronic 

ethanol self-administration on hippocampal serotonin 

transporter density in rhesus macaques. E. J. BURNETT*; A. 

T. DAVENPORT; V. M. MAXEY; A. J. BENNETT; S. J. SUOMI; 

K. A. GRANT; D. P. FRIEDMAN. Wake Forest Univ. Sch. 

Med., Natl. Inst. of Child Hlth. and Human Develop., Oregon 

Hlth. Sci. Univ. 

3:00 KK14 474.7 Src activation in the brain following 

repeated ethanol exposure in adolescent rat. N. SEN; K. 

REDDY; R. SIRCAR*. THE FEINSTEIN INSTITUTE FOR 

MEDICAL RESEARCH, Albert Einstein Coll Med/FIMR. 

4:00 KK15 474.8 Nicotine and ethanol co-administration 

leads to higher alcohol intake in adolescent rats, and lower 

nicotine intake in adults. A. LARRAGA*; M. S. MENCHACA; 

M. D. NGUYEN; J. D. BELLUZZI; F. M. LESLIE. Univ. Calif, 

Irvine. 

1:00 KK16 474.9 Changes in the concentration of 

glutamate in the prefrontal cortex induced by alcohol in 

rats with maternal care deprivation. A. ROMANO*, SR; O. 

PROSPERO; M. MENDEZ. Univ. Nacional Autonoma De 

Mexico. 



2:00 KK17 474.10 � Social interaction with an alcohol 

intoxicated or cocaine-injected peer: Social behaviors and 

voluntary alcohol consumption in male and female adolescent 

rats. S. M. SANTOS*; A. M. MALDONADO-DEVINCCI; M. K. 

HENNESSEY; C. L. KIRSTEIN. Univ. of South Florida, Univ. 

of West Florida. 

3:00 KK18 474.11 Effects of binge-like ethanol administration 

during adolescence on the adult prefrontal cortex in male 

and female rats. R. N. SADOWSKI*; W. A. KOSS; L. K. 

SHERRILL; J. M. GULLEY; J. M. JURASKA. Univ. of Illinois at 

Urbana-Champaign. 

4:00 LL1 474.12 Adolescent male and female rats are 

predisposed to greater alcohol intake in adulthood following 

chronic alcohol treatment during adolescence. A. M. 

MALDONADO-DEVINCCI*; E. DONALDSON; N. H. PATEL; 

N. C. MARTINEZ; J. K. MATHEW; S. LOPEZ; L. A. MICHAEL; 

R. RAUDALES, Jr; S. M. SANTOS; Y. A. PATEL; R. A. 

AMANTE; C. L. KIRSTEIN. Univ. South Florida, Univ. of South 

Florida, Columbia Univ. 

1:00 LL2 474.13 In vivo comparison of effects, chronic 

alcohol exposure on glial populations in mice. S. A. 

DOUGHERTY*. California State Univ. 

2:00 LL3 474.14 Prolonged ethanol exposure during 

adolescence relative to exposure during adulthood: ethanol 

pharmacokinetics in male and female rats. S. LOPEZ*; A. M. 

MALDONADO-DEVINCCI; E. DONALDSON; C. L. KIRSTEIN. 

Univ. of South Florida. 

POSTER 

475. Nicotine: Molecular Mechanisms of Addiction 



1:00 LL4 475.1 Use of retrograde lentiviruses to dissect 

neuronal circuits. S. PONS; S. TOLU; M. SOUDANT; U. 

MASKOS*. Inst. Pasteur. 

2:00 LL5 475.2 Mice null for the metabotropic glutamate 

receptor 5 (mGluR5) show attenuated brain reward deficits 

during cocaine and nicotine withdrawal. A. K. STOKER*; B. 

OLIVIER; A. MARKOU. UCSD, Utrecht Univ., Yale Univ. 

3:00 LL6 475.3 cGMP-dependent protein kinase type II 

is required for maintenance of nicotine cue reactivity in mice. 

D. SCOTT*; T. HIRAMOTO; M. LEE; J. SCHLOSSMANN; 

F. HOFMANN; K. TANIGAKI; N. HIROI. Albert Einstein Coll. 

Med., Albert Einstein Col. of Med., Technische Univ. München, 

Shiga Med. Ctr. 

4:00 LL7 475.4 Differential role for beta3-containing 

nicotinic acetylcholine receptors in nicotine and cocaine 

reward. L. M. TUESTA; P. M. JOHNSON; C. D. FOWLER; P. 

J. KENNY*. The Scripps Res. Inst. 

1:00 LL8 475.5 • The role of α3β4* nachrs in nicotine 

dependence. S. S. SANJAKDAR*; K. J. JACKSON; M. J. 

MCINTOSH; M. I. DAMAJ. Virginia Commonwealth Univ., 

Univ. of Utah. 

2:00 LL9 475.6 The involvement of alpha7- and beta4containing 

nicotinic acetylcholine receptors in nicotine 

withdrawal: Studies in knockout mice. A. K. STOKER; B. 

OLIVIER; A. MARKOU*. Univ. of California San Diego, Utrecht 

Univ., Yale Univ. 



3:00 LL10 475.7 Dopaminergic alpha4 containing nicotinic 

receptors are involved in anxiolytic effects of nicotine. T. 

MCGRANAHAN*; T. K. BOOKER; S. F. HEINEMANN. UCSD, 

Salk Inst. for Biol. Studies. 

4:00 LL11 475.8 Selection for high alcohol preference 

results in a greater sensitivity to nicotine in the posterior 

ventral tegmental area as indicated by increased dopamine 

release in the the nucleus accumbens shell. G. A. DEEHAN*; 

S. R. HAUSER; Z. M. DING; E. A. ENGLEMAN; S. N. 

KATNER; W. J. MCBRIDE; Z. A. RODD. Indiana Univ. 

1:00 LL12 475.9 Epigenetic regulation of the BDNF gene 

following behavioral sensitization to nicotine in a rat model 

of novelty-seeking: implications on anxiety-like behavior and 

mossy fibre plasticity. C. AYDIN*; O. OZTAN; C. ISGOR. 

Florida Atlantic Univ. 

2:00 MM1 475.10 • A c-Fos immunoreactivity study of the 

nicotine state as a stimulus in an appetitive conditioning task. 

S. CHARNTIKOV*; M. E. TRACY; R. A. BEVINS. Univ. of 

Nebraska-Lincoln. 

3:00 MM2 475.11 Modulation of nicotine-induced dopamine 

elevations in the nucleus accumbens shell by the PPAR-alpha 

agonist Clofibrate in rats. P. MASCIA; L. V. PANLILIO; Z. 

JUSTINOVA; G. TANDA; S. R. GOLDBERG*. NIDA, IRP, NIH, 

DHHS, Univ. of Maryland Sch. of Med. 

4:00 MM3 475.12 • Investigation of allelic imbalance from 

CHRNA5 and CHRNA3 genes in post-mortem human 

brain regions. G. A. DOYLE*; M. WANG; A. D. CHOU; S. 

E. ARNOLD; R. J. BUONO; W. H. BERRETTINI. Univ. 

Pennsylvania, Veterans Affairs Med. Ctr. - Coatesville. 

1:00 MM4 475.13 Characterization of ANKK1 and its genetic 

variants. W. HUANG*. Univ. of Virginia. 

2:00 MM5 475.14 FAAH deletion confers enhanced 

sensitivity to nicotine-induced increases in nucleus 

accumbens dopamine. F. J. PAVON; N. SIDHPURA*; B. F. 

CRAVATT; L. H. PARSONS. The Scripps Res. Inst. 

3:00 MM6 475.15 L-DOPA and 5-hydroxytryptophan 

attenuate some nicotine rat withdrawal signs. E. F. DOMINO*; 

Y. OHMURA; E. JUTKIEWICZ. Univ. Of Michigan, Univ. of 

Michigan. 

4:00 MM7 475.16 Effects of the NMDA competitive 

receptor antagonist CGP 39551 on nicotine-dependence. M. 

HEFFERNAN; W. HUANG; N. ZHANG; J. A. KING*. Univ. 

Massachusetts Med. Ctr. 

1:00 MM8 475.17 Environmental enrichment decreases the 

locomotor effects of repeated nicotine and the DARPP-32 

activity in the nucleus accumbens. A. M. GOMEZ; N. M. 

MIDDE; J. ZHU*. Univ. of South Carolina. 

POSTER 

476. Nicotine: Neural Mechanisms of Addiction 



1:00 MM9 476.1 Intrinsic plasticity of subicular bursting 

neurons induced by chronic intravenous nicotine. J. CAO*; K. 

RASMUS; N. ORTIZ; J. VARELA; M. MARKS; D. COOPER. 

IBG-CU. 

2:00 MM10 476.2 A model of dopaminergic neuronal 

dynamics within the VTA: Nicotinic effects on burst firing. 

A. M. OSTER*; P. FAURE; B. S. GUTKIN. Ecole Normale 

Superieure, U. Paris VI. 


Mon. PM

3:00 MM11 476.3 Modulation of the nicotine response. H. 

SCHNEIDER*; S. C. EKKER. Depauw Univ., Mayo Clin. 

4:00 MM12 476.4 Rapid electrophysiological effects of 

intravenous nicotine at small doses: Central or peripheral 

triggering? M. LENOIR*; J. TANG; E. KIYATKIN. NIH, NIDA 

(National Inst. On Drug Abuse). 

1:00 MM13 476.5 Nicotine mediated activation of 

dopaminergic neurons in distinct regions of the ventral 

tegmental area. R. ZHAO-SHEA*; L. LIU; M. IMPROGO; 

S. GRADY; P. D. GARDNER; A. R. TAPPER. Univ. of 

Massachusetts Med. Sch., Univ. of Colorado, Boulder. 

2:00 MM14 476.6 Tonic but not phasic dopaminergic 

signaling mediates the aversive motivational response to 

nicotine withdrawal. T. E. GRIEDER*; O. GEORGE; S. R. 

LAVIOLETTE; H. TAN; B. LE FOLL; D. VAN DER KOOY. Univ. 

Toronto, The Scripps Res. Inst., Univ. of Western Ontario. 

3:00 NN1 476.7 • Acute and chronic effects of nicotine on 

GABA neurons in the ventral tegmental area. D. H. TAYLOR; 

P. N. BURMAN; R. S. WILCOX; K. RINGER; C. B. MERRILL; 

S. N. SUDWEEKS*; J. G. EDWARDS; H. R. ARIAS; S. C. 

STEFFENSEN. Brigham Young Univ., Midwestern Univ. 

4:00 NN2 476.8 Angiotensin AT1 and AT2 receptors 

modulate the effect of nicotine to evoke neurotransmitter 

release. S. SEN*; V. NARAYANASWAMI; D. B. HORTON; L. 

A. CASSIS; L. P. DWOSKIN. Univ. of Kentucky. 

1:00 NN3 476.9 Identification of neuronal structures 

involved in the Cannabinoid type1 receptors modulation of 

the reinforcing properties of Nicotine. A. SIMONNET*; M. 

CADOR; S. CAILLE. Cnrs Umr5227. 

2:00 NN4 476.10 • Blockade of α1-adrenergic receptors 

prevents the deficit in brain reward function associated 

with nicotine withdrawal in rats. A. W. BRUIJNZEEL*; K. F. 

M. KEIJZERS; I. A. VAN TUIJL; E. SMALL; T. PASEK; K. 

YAVAROVICH; J. FORD; J. C. ALEXANDER. Univ. Florida. 

3:00 NN5 476.11 Iptakalim, a potentially new compound 

for smoking cessation. D. R. LECAVALIER*; E. SCHMIDT; C. 

WU; J. WU. Barrow Neurolog. Inst. 

4:00 NN6 476.12 • Effects of nicotine and varenicline at α6 

containing nAChRs: relevance for nicotine dependence. S. 

VALERA; S. BERTRAND; H. ROLLEMA*; R. S. HURST; D. 

BERTRAND. HiQScreen Sàrl, Pfizer Global Res. & Dev. 

1:00 NN7 476.13 Conditioned stimulus effects of nicotine 

and varenicline substitution in female rats. R. J. POLEWAN*; 

M. E. TRACY; L. HOFFMAN; R. A. BEVINS. Univ. of 

Nebraska-Lincoln. 

2:00 NN8 476.14 Effects of acute and chronic varenicline 

administration in mice. N. C. ORTIZ; S. R. GRADY*; M. J. 

MARKS. Univ. Colorado. 

3:00 NN9 476.15 The nicotinic receptor partial agonist 

cytisine: Characterization of behavioral effects in comparison 

to nicotine. O. A. DRAVOLINA*; E. V. RADCHENKO; A. Y. 

BESPALOV. Pavlov State Med. Univ., Abbott. 

4:00 NN10 476.16 Rats will self-administer nicotine directly 

into the hippocampal formation. M. J. FARQUHAR*; P. WINN. 

Univ. of Strathclyde. 

1:00 NN11 476.17 The insula and the orbitofrontal cortex 

separately mediate distinct forms of cue reactivity in nicotine 

addiction. N. HIROI*; D. SCOTT. Albert Einstein Col. Med., 

Albert Einstein Col. of Med. 


2:00 NN12 476.18 The involvement of infralimbic cortical 

nicotinic acetylcholine receptors in impulsive action: 

differential roles of endogenous acetylcholine and exogenous 

nicotine. I. TSUTSUI-KIMURA; T. IZUMI*; Y. OHMURA; T. 

YAMAGUCHI; T. YOSHIDA; M. YOSHIOKA. Hokkaido Univ. 

Grad. Sch. of Med., Hokkaido Univ. Sch. Med. 

3:00 NN13 476.19 Gestational ethanol exposure enhances 

adolescent cue-induced nicotine seeking by disinhibiting the 

dorsal medial prefrontal cortex. S. G. MATTA*; H. CHEN; J. D. 

STEKETEE; B. M. SHARP. Univ. Tennessee Hlth. Sci. Cnt. 

4:00 NN14 476.20 Acute restraint stress prevents 

nicotine-induced mesolimbic dopaminergic activation via 

a corticosterone-mediated mechanism. A microdialysis 

study in the rat. P. ENRICO*, Dr.; D. SIRCA; M. MEREU; 

G. MUGGIRONI; A. T. PEANA; M. DIANA. Univ. of Sassari, 

NIDA. 

1:00 OO1 476.21 Social interaction permits nicotine selfadministration 

with contingent olfactogustatory cues in 

adolescent rats. H. CHEN*; B. M. SHARP; S. G. MATTA; Q. 

WU; X. WU. Univ. Tennessee Hlth. Sci. Ctr. 

2:00 OO2 476.22 Anxiety-like behavior predicts the 

motivation for nicotine after abstinence in rats with extended 

access to nicotine self-administration. O. GEORGE*; G. 

KOOB. Scripps Resch Inst., The Scripps research Inst. 

3:00 OO3 476.23 Behavioral, biochemical, and molecular 

indices of nicotine withdrawal: Differential impact of sex on 

stress-related markers. O. V. TORRES*; L. A. NATIVIDAD; E. 

M. WALKER; A. K. MUÑIZ; D. M. BYERS; L. E. O’DELL. Univ. 

of Texas At El Paso. 

4:00 OO4 476.24 Evaluating working memory performance 

in heavy cigarette smokers using fMRI: Indvidual differences 

in working memory capacity and effects of distraction. 

R. MACLEAN; S. J. WILSON*; M. SAYETTE; J. FIEZ. 

Pennsylvania State Univ., Univ. of Pittsburgh. 

1:00 OO5 476.25 Brain responses associated with selective 

attention to smoking-related visual cues in smokers: An fMRI 

study. O. KANG*; S. KIM; G. JAHNG; H. KIM; H. LEE; H. 

PARK; Y. CHAE. Kyung Hee Univ., East-West Neo Med. 

Center, Sch. of Medicine, Kyung Hee Univ., Korea Univ. 

2:00 OO6 476.26 Effect of nicotine administration on cueinduced 

neural response. W. HUANG; G. DIGIROLAMO; N. 

ZHANG*; J. DIFRANZA; J. KING. Ctr. For Comparative Neuro 

Imaging, Col. of the Holy Cross, Univ. of Massachusetts Med. 

Sch. 

3:00 OO7 476.27 Effect of bupropion HCl treatment on 

brain activation induced by cigarette cues in smokers. C. 

CULBERTSON*; M. COHEN; E. LONDON; J. BRAMEN; A. 

BRODY. UCLA. 

4:00 OO8 476.28 • GRONS: Genetic resources of nicotine 

and smoking. J. WANG*; M. LI. Univ. Virginia. 

POSTER 

477. Amphetamines: Toxicity I 



1:00 OO9 477.1 Caffeine potentiates 

3,4-methylenedioxymethamphetamine (MDMA, ecstasy)induced-glial 

activation: role of age and adenosine A 1 and A 2A 

receptors. M. MORELLI*; L. FRAU; A. KHAIRNAR; S. FENU. 

Univ. Cagliari. 



2:00 OO10 477.2 Involvement of two distinct mechanisms 

for MDMA-evoked increases in extracellular 5-HT in the 

prefrontal cortex of rat brain. R. TAO*; Z. MA. Florida Atlantic 

Univ. 

3:00 OO11 477.3 Role of metabolism in 

3,4-(±)-methylenedioxymethamphetamine-induced 

neurotoxicity: Contribution of cytochrome p450 2d6 and 

catechol-o-methyl transferase. J. M. HERNDON; A. B. 

CHOLANIANS; G. V. ERIVES; S. S. LAU; G. W. MILLER*; T. 

J. MONKS. Univ. of Arizona, Whitehead Biomed Res. Bldg. 

4:00 OO12 477.4 � Microglial response to 

3,4-(±)-methylenedioxymethamphetamine in sprague-dawly 

rats. A. B. CHOLANIANS; J. M. HERNDON; X. LI; F. BAI; 

S. S. LAU; J. Y. LAI*; T. J. MONKS. Univ. of Arizona Col. of 

Pharm., Univ. Arizona Col. Med. 

1:00 OO13 477.5 Genetic and environmental 

factors are involved in the susceptibility to tau protein 

phosphorylation in mouse brains after treatment with 

3,4-methylendioxymethamphetamine (“ecstasy”). F. 

BIAGIONI; C. L. BUSCETI; B. RIOZZI; G. BATTAGLIA; V. 

BRUNO; F. FORNAI; F. NICOLETTI*. I.N.M. Neuromed, Univ. 

Rome, Dept. of Human Morphology and Applied Biol. Univ. of 

Pisa. 

2:00 OO14 477.6 • MDMA-induced activation of the HPA 

axis involves 5-HT1 A receptors and the PVN, but not 5-HT1 A 

receptors in the PVN. D. V. ZARETSKY*; M. V. ZARETSKAIA; 

J. A. DIMICCO; D. E. RUSYNIAK. Indiana Univ. Sch. of Med. 

3:00 OO15 477.7 Paroxetine pretreatment blunts 

3,4-methylenedioxymethamphetamine preconditioning in a rat 

model of intermittent adolescent exposure. J. S. MEYER*; E. 

Y. SHEN; K. E. JANKO. Univ. Massachusetts. 

4:00 OO16 477.8 Effects of repeated 

administration of delta9-tetrahydrocannabinol and 

3,4-methylenedioxymethamphetamine to adolescent rats 

on regional serotonin and dopamine transporter binding. E. 

Y. SHEN*; C. L. PINHAL; A. F. CHAUDHRY; J. S. MEYER. 

UMass, Univ. Massachusetts. 

1:00 OO17 477.9 Investigating the role of serotonin in 

methamphetamine neurotoxicity. D. M. THOMAS*; M. 

M. SHAH; M. ANGOA-PEREZ; D. M. FRANCESCUTTI- 

VERBEEM; C. E. SYKES; D. M. KUHN. Wayne State Univ., 

John D. Dingell VAMC. 

2:00 OO18 477.10 Cortical serotonin depletion following 

neonatal administration of MDMA and methamphetamine in 

rat. J. M. DAVIS; R. D. MOONEY; B. K. YAMAMOTO; R. D. 

LANE; N. L. CHIAIA*. Univ. of Toledo Hlth. Sci. Campus. 

3:00 PP1 477.11 Methyllycaconitine protects against 

methamphetamine-induced damage to dopamine terminals in 

the rat striatum. N. A. FAZO*; L. P. SMITH; B. K. YAMAMOTO; 

D. J. EYERMAN. Boston Univ. Sch. of Med., Univ. of Toledo. 

4:00 PP2 477.12 Methamphetamine (MA) and 

3,4-methylenedioxymethamphetamine (MDMA) produce a 

subregional decrease in serotonin neurons within the dorsal 

raphe nucleus. R. NATARAJAN*; B. K. YAMAMOTO. Univ. of 

Toledo. 

1:00 PP3 477.13 Effects of methamphetamine on longterm 

changes in permeability and proteins associated with 

the blood brain barrier. L. E. HALPIN*; N. A. FAZO; B. K. 

YAMAMOTO. Univ. of Toledo, Boston Univ. Sch. of Med. 

2:00 PP4 477.14 Cortical NMDA and AMPA glutamate 

receptors mediate methamphetamine-induced striatal 

neurotoxicity. N. B. GROSS*; P. C. DUNCKER; J. F. 

MARSHALL. Univ. California,Irvine. 



3:00 PP5 477.15 Repeated methamphetamine 

administrations during development attenuates the response 

to a subsequent challenge methamphetamine administration. 

A. J. HOONAKKER; P. L. VIEIRA-BROCK; K. A. STOUT; J. 

D. ELLIS; S. C. ALLEN; E. T. WALTERS; J. W. MCDOUGALL; 

S. M. NIELSEN; L. M. MCFADDEN; M. E. ALBURGES; 

D. G. WILKINS; J. W. GIBB*; G. R. HANSON; A. E. 

FLECKENSTEIN. Univ. Utah. 

4:00 PP6 477.16 Methamphetamine self-administration 

leads to persistent dopaminergic deficits. L. M. MCFADDEN*; 

G. R. HANSON; A. E. FLECKENSTEIN. Univ. of Utah. 

1:00 PP7 477.17 Methamphetamine self-administration 

leads to acute changes to dopaminergic markers. L. M. 

MCFADDEN; G. R. HANSON; A. E. FLECKENSTEIN*. Univ. 

Utah. 

2:00 PP8 477.18 Age-dependent multiple high-dose 

methamphetamine-induced alterations in monoaminergic 

systems and the effect of escalating, low-dose 

methamphetamine pretreatment. S. M. NIELSEN; K. L. 

JOHNSON-DAVIS; J. W. GIBB; G. R. HANSON; A. E. 

FLECKENSTEIN; D. G. WILKINS*. Univ. of Utah. 

3:00 PP9 477.19 Nicotine pretreatment attenuates 

methamphetamine-induced striatal dopaminergic deficits. P. L. 

VIEIRA-BROCK*; K. A. STOUT; A. J. HOONAKKER; P. CHU; 

E. T. WALTERS; J. MCDOUGALL; L. M. MCFADDEN; D. G. 

WILKINS; G. R. HANSON; A. E. FLECKENSTEIN. Univ. of 

Utah. 

4:00 PP10 477.20 Increase in CD4:CD8 lymphocyte 

ratio and plasma corticosterone in peripheral blood of rats 

after repeated intravenous cocaine. M. JANKOWSKI*; B. 

IGNATOWSKA-JANKOWSKA; W. GLAC; A. H. SWIERGIEL. 

Univ. of Gdansk, Dept. of Animal Physiol. 

POSTER 

478. Addiction: Genetics 



1:00 PP11 478.1 • Morphine induced locomotion and 

ultrasonic vocalizations in M5 KO mice rescued by viral 

transfection of M5 muscarinic receptors in ventral tegmentum. 

D. WASSERMAN*; E. LEE; H. WANG; S. JOSSELYN; A. 

RASHID; J. YEOMANS. Yeomans Lab., Univ. of Toronto, The 

Hosp. for Sick Children Res. Inst. 

2:00 PP12 478.2 Fine-scale mapping of a 3 cM 

genetic locus on mouse chromosome 11 influencing 

methamphetamine sensitivity. C. D. BRYANT*; A. HART; H. 

DE WIT; A. A. PALMER. Univ. Chicago. 

3:00 PP13 478.3 Differential gene expression of 

phenotypically specific neurons in two inbred strains of rats 

with different drug-taking behavior. B. M. SHARP*; H. CHEN; 

S. GONG; X. WU; Z. LIU; W. L. TAYLOR; S. G. MATTA. Univ. 

Tennessee Memphis. 

4:00 PP14 478.4 Transcriptome sequencing of nucleus 

accumbens neurons projecting to ventral pallidum in 

adolescent rats. Z. LIU; H. CHEN; X. WU*; S. GONG; W. 

L. TAYLOR; R. W. WILLIAMS; S. G. MATTA; B. M. SHARP. 

Universisty of Tennessee Hlth. Sci. Ctr., Univ. of Tennessee 

Hlth. Sci. Ctr. 

1:00 PP15 478.5 Gene knockout of the orphan receptor 

GPR88 in mice. J. A. J. BECKER; T. ARBOGAST; M. 

BIRLING; A. MATIFAS; B. L. KIEFFER*. IGBMC - CERBM. 


Mon. PM

2:00 PP16 478.6 Long-term chromatin modification and 

behavioural disorders associated with maternal separation in 

rats. A. KALDA*; K. MALINOVSKAJA; K. ANIER; K. PRUUS; 

A. ZHARKOVSKY. Univ. Tartu. 

3:00 PP17 478.7 • Navigating a sea of genes: Using 

convergent data to find common and unique substrates for 

predisposing behavior, drug abuse and alcoholism with the 

Ontological Discovery Environment. J. J. JAY; V. M. PHILIP; 

M. A. LANGSTON; E. J. BAKER; E. J. CHESLER*. The 

Jackson Lab., Univ. of Tennessee / Oak Ridge Natl. Lab., 

Baylor Univ. 

4:00 PP18 478.8 Integrating convergent evidence across 

species to find QTL candidate genes using the Ontological 

Discovery Environment. V. M. PHILIP*; J. J. JAY; M. A. 

LANGSTON; E. J. BAKER; E. J. CHESLER. Univ. Tennessee, 

The Jackson Lab., Univ. of Tennessee, Baylor Univ. 

1:00 QQ1 478.9 Novel alternative splicing patterns of 

human gamma-aminobutyric acid type B Receptor subunit 1 

(GABAB1): Studies in alcoholics. C. LEE*; R. D. MAYFIELD; 

R. A. HARRIS. The Univ. of Texas at Austin. 

2:00 QQ2 478.10 Association of the CHRNA5-A3-B4 gene 

cluster with heaviness of smoking. J. J. WARE*; M. VAN DEN 

BREE; M. R. MUNAFÒ. Cardiff Univ., Univ. of Bristol. 

3:00 QQ3 478.11 Variants in the neuregulin 1 gene are 

associated with nicotine dependence. K. J. JACKSON*; J. 

CHEN; K. S. KENDLER; X. CHEN. Virginia Commonwealth 

Univ. 

POSTER 

479. Olfactory Cortex, Anterior Olfactory Nucleus, and 

Olfactory Amygdala 



1:00 QQ4 479.1 Dynamic routing of inhibition by 

complementary interneuron microcircuits in olfactory cortex. 

C. C. A. STOKES; J. S. ISAACSON*. UCSD. 

2:00 QQ5 479.2 The contribution of intracoritcal inputs in 

shaping odor-evoked activity in piriform cortex. C. POO*; J. S. 

ISAACSON. UCSD. 

3:00 QQ6 479.3 Modulatory actions of basolateral 

amygdaloid fibers on local piriform cortex circuits. V. M. 

LUNA*; A. MOROZOV. Natl. Inst. of Mental Hlth. 

4:00 QQ7 479.4 Potential inhibitory mechanisms 

modulating responses to chemosignals in medial amygdala. 

L. M. SILZ; A. R. SIMONTON; M. MEREDITH*. Florida State 

Univ. 

1:00 QQ8 479.5 Interneuron populations in the mouse 

anterior olfactory nucleus. P. C. BRUNJES*; R. KAY. Univ. 

Virginia, Univ. of Virginia. 

2:00 QQ9 479.6 Synaptic mechanisms that coordinate 

the activity of GABAergic interneurons and pyramidal cells in 

the mouse piriform cortex. D. C. SHERIDAN*; F. ERDÉLYI; 

G. SZABÓ; N. E. SCHOPPA. Univ. of Colorado Denver - 

Anschutz Med. Campus, Inst. of Exptl. Med. 

3:00 QQ10 479.7 Feedforward and feedback inhibitory 

microcircuits in the anterior piriform cortex. N. SUZUKI; J. M. 

BEKKERS*. John Curtin Sch. Med. Res. 


4:00 QQ11 479.8 Optogenetic analysis of association 

circuitry in the olfactory cortex. A. HAGIWARA*; T. F. SATO; 

M. WIENISCH; V. N. MURTHY. Harvard Univ. 

1:00 QQ12 479.9 Diverse response selectivity of odorants 

in the anterior piriform cortex of awake, behaving mice. C. 

ZHAN; M. LUO*. Natl. Inst. of Biol. Sci. 

2:00 QQ13 479.10 Odor concentration dependent neuronal 

activities in the anterior piriform cortex. A. SHIMIZU*; J. 

WANG; K. TSUTSUI; T. IIJIMA. Grad. Sch. of Life Sciences, 

Tohoku Univ. 

3:00 QQ14 479.11 Respiration frequencies switch cortical 

responsiveness to mitral cell population activity. A. M. 

OSWALD*; N. N. URBAN. Carnegie Mellon Univ. 

4:00 QQ15 479.12 Odor fear conditioning modifies piriform 

cortical odor processing of learned odors in awake rats in a 

manner which predicts behavioral fear. C. F. CHEN*; D. A. 

WILSON. Nathan Kline Inst., Univ. of Oklahoma, NYU Sch. of 

Med. 

1:00 QQ16 479.13 Odor memory and olfactory system slowwave 

sleep. D. BARNES*; J. CHAPUIS; D. CHAUDHURY; 

D. WILSON. Nathan Kline Inst., City Univ. of New York, New 

York Univ. Sch. of Med. 

2:00 QQ17 479.14 Characterization of centrifugal cells within 

the olfactory cortex. A. N. YOUNG*; Q. SUN. Univ. Wyoming. 

3:00 QQ18 479.15 Enhancement of neural activities in the 

olfactory network induced by repetitive inputs to the olfactory 

nerve as revealed by voltage-sensitive dye imaging. R. 

KAJIWARA*; T. TOMINAGA; I. TAKASHIMA. Natl. Inst. Adv 

Indus Sci. & Tech., Tokushima Bunri Univ. 

POSTER 

480. Auditory Processing: Sound Localization and Binaural 

Interactions 



1:00 QQ19 480.1 • Binaural processing in ei neurons revealed 

with in vivo whole cell recordings. N. LI*; G. POLLAK. Univ. of 

Texas At Austin, Univ. of Texas at Austin. 

2:00 QQ20 480.2 Synaptic mechanisms of binaural 

interactions in rat primary auditory cortex. M. KYWERIGA*; W. 

N. WOLFE; C. C. CAHILL; M. WEHR. Univ. of Oregon. 

3:00 RR1 480.3 The distance-dependence of interaural 

level difference cues to sound location and their encoding by 

neurons in the inferior colliculus. H. G. JONES*; K. KOKA; 

J. THORNTON; D. TOLLIN. Univ. of Colorado Denver Med. 

School, Neurosci. Program, Univ. of Colorado Denver Med. 

Sch. 

4:00 RR2 480.4 Physical modeling of the signal filtering 

properties of asymmetrical ear forms in echolocating bats. 

G. E. PERRIN*; F. W. GRASSO. Brooklyn Col. of The City 

Univ. of New York, The BioMimetic and Cognitive Robotics 

Laboratory, Brooklyn Col. of The City Univ. of New York, The 

Grad. Ctr. of The City Univ. of New York. 

1:00 RR3 480.5 Spatial receptive fields in neurons of the 

central nucleus of the inferior colliculus measured with infant 

and adult acoustical cues. K. KOKA*; J. L. THORNTON; H. 

G. JONES; D. J. TOLLIN. Univ. of Colorado Denver Anschutz 

Med. Campus. 



2:00 RR4 480.6 • Neural mechanisms of binaural masking 

release. H. GILBERT; C. LANTING; R. MASON*; K. 

KRUMBHOLZ. MRC Inst. of Hearing Research, UK, Univ. 

Nottingham Med. Sch. 

3:00 RR5 480.7 A developmental explanation of the 

dependence of binaural best delays on characteristic 

frequency. B. FONTAINE; D. F. GOODMAN*; R. BRETTE. 

Ecole Normale Superieure. 

4:00 RR6 480.8 Bayesian inference predicts soundlocalizing 

behavior and neural representation in the barn owl. 

B. J. FISCHER*; S. DENEVE; J. L. PENA. Ecole Normale 

Superieure, Albert Einstein Col. of Med. 

1:00 RR7 480.9 Neurophysiological validation of a virtualspace 

stimulation technique to study the neural consequences 

of conductive hearing loss. J. L. THORNTON*; K. KOKA; H. 

JONES; D. TOLLIN. Univ. of Colorado Sch. of Med. 

2:00 RR8 480.10 Azimuthal tuning of inferior colliculus 

neurons in the unanesthetized rabbit to virtual auditory 

space stimuli. S. KUWADA*; B. BISHOP; D. O. KIM. Univ. 

Connecticut Hlth. Ctr. 

3:00 RR9 480.11 The structure of spatial receptive fields of 

neurons in the primary auditory cortex of awake marmoset. Y. 

ZHOU*; X. WANG. Johns Hopkins Univ. 

4:00 RR10 480.12 Time course of adaptation to stimulus 

statistics in the perception and neural representation of 

auditory space. J. C. DAHMEN*; P. KEATING; A. J. KING. 

Oxford Univ. 

1:00 RR11 480.13 Neural responses to simulated echoes 

in the auditory cortex of the ferret. S. TOLNAI; N. C. 

RABINOWITZ; B. D. B. WILLMORE; R. Y. LITOVSKY; A. J. 

KING*. Univ. of Oxford, Univ. of Wisconsin. 

2:00 RR12 480.14 Information conveyed by inferior colliculus 

neurons about stimuli with aligned and misaligned sound 

localization cues. S. J. SLEE*; E. D. YOUNG. Johns Hopkins 

Univ. 

3:00 RR13 480.15 • Effects of cochlear delay in the ITD 

processing in NL. I. FUKUI*; H. OHMORI. Dept. of Physiol. 

and Neurology, Fac. of Medicine, Kyoto Univ. 

4:00 RR14 480.16 Effect of motion adaptation on motiononset 

auditory evoked potentials. M. B. HOFFMANN*; M. 

BÖCKMANN-BARTHEL; R. MÜHLER; R. GRZESCHIK. Univ. 

Magdeburg. 

1:00 RR15 480.17 Neurophonic maps of ITD in nucleus 

laminaris of the barn owl. C. E. CARR*; G. ASHIDA; S. SHAH; 

S. BRILL; P. KUOKKANEN; R. KEMPTER; H. WAGNER. 

Univ. Maryland, RWTH Aachen, Humboldt Univ. 

2:00 RR16 480.18 A comparison of binaural interaction 

patterns and binaural cue tuning in human auditory cortex. G. 

STECKER*; S. A. MCLAUGHLIN. Univ. Washington. 

3:00 RR17 480.19 Binaural unmasking of frequency-following 

responses in the rat amygdala. L. KONG; T. MA; Y. DU; H. LI; 

L. LI*; X. WU. Peking Univ. 



POSTER 

481. Auditory Processing: Temporal and Spectral factors I 



1:00 RR18 481.1 Corticofugal influence on temporal 

modulation processing in auditory thalamus of awake 

marmosets. M. JESCHKE*; F. W. OHL; X. WANG. BioFuture 

Res. Group, Leibniz Inst. For Neurobio., Johns Hopkins 

University, Dept. of Biomed. Engin., Inst. for Biology, Otto-von- 

Guericke Univ. Magdeburg. 

2:00 RR19 481.2 Is the cortical code for musical pitch 

invariant to the stimulus frequency composition? G. 

R. HUTCHINSON; J. DE BOER; J. W. PEIRCE*; K. 

KRUMBHOLZ. MRC Inst. of Hearing Res., Nottingham Univ. 

3:00 RR20 481.3 An efficient, invertible contour-based 

representation of natural sounds. Y. S. LIM; B. G. SHINN- 

CUNNINGHAM; T. J. GARDNER*. Boston Univ. 

4:00 SS1 481.4 Comparing components of auditory nerve 

signal in each ear of acoustic schwannoma patients using 

magnatoencephalography. D. LEE*; J. CHANG. Yonsei Univ. 

Coll. of Med., Brain Korea 21 Project for Med. Science, Yonsei 

Univ. 

1:00 SS2 481.5 Detection of amplitude modulation as 

a function of modulation frequency and stimulus duration: 

Comparisons between macaques and humans. K. N. 

O’CONNOR*; J. S. JOHNSON; M. NIWA; N. C. NORIEGA; E. 

A. MARSHALL; M. L. SUTTER. UC Davis. 

2:00 SS3 481.6 Repetition suppression for a pitch 

stimulus. S. KUMAR*; C. POIRIER; S. BAUMANN; T. 

GRIFFITHS. Newcastle Univ. 

3:00 SS4 481.7 Investigating differences in the N1 

modulation for self-initiated and external sounds in patients 

with cerebellar or basal ganglia lesions. F. GRIMM*; E. 

SCHREOGER; P. BAESS; S. A. KOTZ. Max Planck Inst. For 

Human Cognitive and Brain Sci., Leipzig Univ. 

4:00 SS5 481.8 Cortical responses to cochlear implant 

stimulation in the awake marmoset. L. A. JOHNSON*; C. 

C. DELLA SANTINA; X. WANG. Dept Biomed Eng, Johns 

Hopkins Univ., Dept of Otolaryngology-Head & Neck Surgery, 

Johns Hopkins Univ. 

1:00 SS6 481.9 Neural discrimination of FM sweep 

direction and duration using pattern classification. I. HSIEH*; 

P. FILLMORE; F. RONG; T. MUFTULER; G. HICKOK; K. 

SABERI. Natl. Central Univ., Univ. of California-Irvine. 

2:00 SS7 481.10 • A network model of frequency sweep 

detection in the auditory cortex. S. W. SKORHEIM*; K. 

RAZAK; M. BAZHENOV. Univ. of California, Riverside. 

3:00 SS8 481.11 The role of interactions between excitatory 

and inhibitory receptive field components in encoding 

harmonic structures in auditory cortex of awake marmosets. L. 

FENG*; X. WANG. Johns Hopkins Univ. 

4:00 SS9 481.12 The caudomedial area of rhesus 

monkey auditory cortex revisited. P. KUSMIEREK*; J. P. 

RAUSCHECKER. Georgetown Unive. 

1:00 SS10 481.13 Sensitivity to bandwidth and modulation 

frequency in the human auditory system. Y. ZHANG*; T. 

OVERATH; D. SANES; D. POEPPEL. New York Univ. 

2:00 SS11 481.14 Age-related changes in the auditory 

evoked response are mitigated by musical training. B. R. 

ZENDEL*; C. ALAIN. Univ. of Toronto. 


Mon. PM

3:00 SS12 481.15 Tone-elicited response patterns recorded 

directly from human auditory cortex on the posterior lateral 

superior temporal gyrus. M. STEINSCHNEIDER*; K. 

NOURSKI; H. KAWASAKI; H. OYA; M. HOWARD. Albert 

Einstein Med. Col., Univ. of Iowa. 

4:00 SS13 481.16 Phase-locked neural oscillation predicts 

human auditory brainstem responses to musical intervals. E. 

W. LARGE*; F. V. ALMONTE. Florida Atlantic Univ. 

1:00 SS14 481.17 Sharp frequency tuning in the auditory 

periphery of old-world monkeys. P. X. JORIS*; M. MC 

LAUGHLIN; P. MICHELET; M. VAN DER HEIJDEN. KU 

Leuven. 

POSTER 

482. Auditory Processing: Cortical Circuits, Synapses, and 

Neurotransmitters 



1:00 SS15 482.1 Anatomical connections of the rostral 

supratemporal plane in rhesus monkeys. B. H. SCOTT*; H. 

VINAL; M. MISHKIN; R. C. SAUNDERS. NIMH. 

2:00 SS16 482.2 Anatomical description of amygdalar 

neurons that project to primary auditory cortex in the rat. D. C. 

PETERSON*. Iowa State Univ. 

3:00 SS17 482.3 Non-overlapping sets of synapses drive 

on-responses and off-responses in auditory cortex. M. S. 

WEHR*. Univ. Oregon. 

4:00 SS18 482.4 Input-dependent switching between cotuned 

and lateral inhibitory configurations in auditory cortex: 

Simulations in vitro. H. SEONG*; A. D. REYES. New York 

Univ. 

1:00 SS19 482.5 Alterations in intrinsic and synaptic 

properties of layer III/IV auditory cortical neurons by 

muscarinic agonists. A. M. CRUZ-TORRES*; C. L. COX. Univ. 

of Illinois at Urbana-Champaign. 

2:00 SS20 482.6 Neurochemical profile of projections 

from the medial geniculate to auditory cortex: Expression 

of parvalbumin and calbindin in the macaque monkey. L. 

A. DE LA MOTHE*; C. R. CAMALIER; T. TAKAHATA; T. A. 

HACKETT. Vanderbilt Univ. 

3:00 TT1 482.7 Probing inhibition in auditory cortex in vitro 

and in vivo with optogenetics. A. REID*; T. HROMADKA; A. M. 

ZADOR. Cold Spring Harbor Lab. 

4:00 TT2 482.8 Convergent integration of driver and 

modulator inputs in the neocortex. C. C. LEE*; S. M. 

SHERMAN. Univ. of Chicago. 

1:00 TT3 482.9 Estrogen-associated networks in the 

mouse primary auditory cortex. R. PINAUD; J. JEONG; V. 

VUONG; L. A. TREMERE*. Univ. Rochester. 

2:00 TT4 482.10 Synaptic input and spike output 

correlations during spontaneous activity evoked in vitro in 

the auditory cortex. M. GRAUPNER*; A. D. REYES. Ctr. For 

Neural Science, NYU. 

3:00 TT5 482.11 Use of complex t-statistics to determine 

the effects of anesthetic agents on spontaneous and stimulusrelated 

network activity in auditory cortex. M. I. BANKS*; B. M. 

KRAUSE. Univ. of Wisconsin. 


4:00 TT6 482.12 Functional input from prefrontal cortex 

to auditory cortex in the mouse. D. E. WINKOWSKI*; S. 

BANDYOPADHYAY; S. A. SHAMMA; P. O. KANOLD. Univ. 

Maryland. 

1:00 TT7 482.13 Developmental sensory experience 

balances cortical excitation and inhibition. K. YUAN*; A. 

L. DORRN; A. J. BARKER; C. E. SCHREINER; R. C. 

FROEMKE. UCSF, Dept. of Neuroscience, Max-Delbrück Ctr. 

for Mol. Med., New York Univ. Sch. of Med. 

2:00 TT8 482.14 Physiological correspondence 

determines long-term potentiation and depression of auditory 

thalamocortical transmission. X. LIU; J. YAN*. Univ. of Calgary 

Fac. of Med. 

3:00 TT9 482.15 Receptive field properties of layer5 

neurons in rat auditory cortex. Y. J. SUN*; Y. ZHOU; H. W. 

TAO; L. I. ZHANG. USC Zilhka Neurogenetic Inst. 

4:00 TT10 482.16 Homeostatic plasticity and tuning 

in the primary auditory cortex after hearing loss. M. 

CHROSTOWSKI*; D. J. STOLZBERG; S. BECKER; I. C. 

BRUCE; R. J. SALVI. McMaster Univ., Univ. at Buffalo. 

POSTER 

483. Striate Cortex: functional Organization 



1:00 TT11 483.1 Neuronal selectivity and microcirculation 

localized at columnar level in primate visual cortex. Z. 

WANG*; A. W. ROE. Vanderbilt Univ. 

2:00 TT12 483.2 Local organization of second-order 

processing in early visual cortex: evidence from spikes and 

local field potentials. G. LI*; C. L. BAKER. McGill Vision Res. 

3:00 TT13 483.3 Complex cells in V1 are more engaged 

in network dynamics than simple cells. D. P. SCHULZ*; 

A. BENUCCI; L. BUSSE; S. KATZNER; M. SAHANI; M. 

CARANDINI. Univ. Col. London, Univ. of Tuebingen. 

4:00 TT14 483.4 Does functional columnar organization 

extend across hemispheric boundaries? Y. ASADA*; S. 

NISHIMOTO; T. M. SANADA; I. OHZAWA. Grad. Sch. of 

Frontier Biosciences, Osaka University., Helen Wills Neurosci. 

Institute, Univ. of California, Univ. of Rochester, Osaka Univ. 

1:00 TT15 483.5 Assessing the spatial precision of 

high-resolution echo-planar functional MRI at 3T and 

7T. D. SCHLUPPECK*; E. P. MERRIAM; R. SANCHEZ- 

PANCHUELO; S. FRANCIS; R. BOWTELL; P. VELASCO; S. 

INATI; D. J. HEEGER. Univ. of Nottingham, New York Univ., 

NIH. 

2:00 TT16 483.6 Relationship between cortical structures of 

ocular dominance and binocular disparity: A model study. M. 

MIYASHITA*; S. TANAKA. Numazu Natl. Col. of Technol., The 

Univ. of Electro-Communications. 

3:00 TT17 483.7 Implicit redundant target effect across the 

vertical meridian, but not horizontal, in a stroke patient with 

an inferior left quadrantanopia. S. ROSSIT*; I. SPERANDIO; 

S. SAVAZZI; J. A. FRASER; M. A. GOODALE. Dept. of 

Psychology, Univ. of Western Ontario, Dept. of Neurolog. and 

Visual Sciences, Univ. of Verona, Dept. of Neurology, Univ. 

Hosp. 

4:00 TT18 483.8 Spatial summation of neurometabolic 

coupling in the visual cortex. B. LI*; R. D. FREEMAN. Univ. of 

CA-Berkeley. 



1:00 TT19 483.9 Multi-feature learning in a SOM-based 

model of the visual cortex. R. JAIN*; B. W. MEL. USC. 

2:00 TT20 483.10 • Segregated ocular dominance domains 

in rat visual cortex: Anatomical and physiological evidence. 

R. LAING*; H. LU; J. TURECEK; J. F. OLAVARRIA. Univ. of 

Washington. 

3:00 UU1 483.11 A model for functional diversity in primary 

visual cortex. A. W. FREEMAN*; N. HESAM SHARIATI. Univ. 

Sydney, Univ. of Sydney. 

4:00 UU2 483.12 Anisotropic orientation selectivity of 

monkey V1 neurons in Cartesian and polar coordinates. E. 

ZHANG*; M. HUANG; X. XIANG; Y. YAN; Y. SHEN; M. CHEN; 

X. XU; W. LI. Beijing Normal Univ. 

1:00 UU3 483.13 Effects of cannabinoid CB1 receptor on 

hemodynamic responses and functional organization of the 

primary visual cortex. R. ABBAS FARISHTA; C. ROBERT; M. 

P. VANNI; K. MINVILLE; J. BOUCHARD*; C. CASANOVA. 

Univ. Montreal. 

2:00 UU4 483.14 Pinwheel neurons show orientation 

variance while domain neurons show more stability to spatial 

and contrast perturbations in cat V1. M. HASHEMI-NEZHAD*; 

D. C. LYON. Univ. of California. 

3:00 UU5 483.15 Orientation tuning of cells in cytochrome 

oxidase patches of macaque striate cortex examined with 

100-microelectrode arrays. J. R. ECONOMIDES*; L. C. 

SINCICH; D. L. ADAMS; J. C. HORTON. UCSF. 

4:00 UU6 483.16 • A statistical connectivity model predicts 

contralateral dominance, species dependence and spatial 

periodicity of orientation maps in V1. Y. MENG*; S. TANAKA; 

C. POON. MIT, The university of Electro-Communications. 

1:00 UU7 483.17 Topographic map of orientation in 

human visual cortex. J. FREEMAN*; G. J. BROUWER; D. J. 

HEEGER; E. P. MERRIAM. New York Univ. 

2:00 UU8 483.18 Estimating cortical maps with Gaussian 

process models. J. H. MACKE; G. SEBASTIAN; L. E. WHITE; 

M. KASCHUBE; M. BETHGE*. Univ. Col. London, Univ. of 

Tübingen, MPI for Biol. Cybernetics, Tübingen, Duke Univ., 

Princeton Univ., MPI Biol Cybernetics. 

3:00 VV1 483.19 Cortical responses to visually presented 

fragmented images recorded from patients implanted with 

sub-dural electrodes. F. LEPORE*; J. BERTRAND; M. 

LASSONDE; M. DOUCET; D. NGUYEN; M. ROBERT; A. 

BOUTHILLIER. Univ. Montreal. 

4:00 VV2 483.20 Functional characterization of neuronal 

populations in striate and extrastriate regions of the mouse 

visual cortex. M. GARRETT*; J. H. MARSHEL; I. NAUHAUS; 

E. M. CALLAWAY. The Salk Inst. For Biol. Studies, UCSD. 

1:00 VV3 483.21 Functional organization of the mouse 

LGN examined with in vivo two-photon calcium imaging. A. 

P. KAYE*; J. H. MARSHEL; I. NAUHAUS; E. M. CALLAWAY. 

Salk Inst. For Biol. Studies, UCSD. 

2:00 VV4 483.22 Mapping collinear subthreshold facilitation 

using sparse apparent motion noise. P. V. CARELLI*; M. 

PANANCEAU; C. MONIER; Y. FREGNAC. UNIC-CNRS. 



POSTER 

484. Striate Cortex: Receptive fields and Response Properties 



1:00 VV5 484.1 • Suggestion of method for objective 

testing of visual function in rats. R. S. IVANOV*; E. E. 

MINAKOVA; I. V. BONDAR. Inst. for Higher Nervous 

Activity&Neurophysiology, RAS. 

2:00 VV6 484.2 Trial linked hemodynamic activity is 

related to performance in a visual discrimination task. J. D. 

ORDINARIO*; S. LEVINE; Y. B. SIROTIN; A. DAS. Columbia 

Univ., Rockefeller Univ. 

3:00 VV7 484.3 Input-output power law in 

electrophysiologically characterized neurons in cat area 17. 

L. G. NOWAK*; M. V. SANCHEZ-VIVES; D. HANSEL; C. 

VAN VREESWIJK; D. A. MCCORMICK. Univ. Paul Sabatier 

- CNRS, Institucio Catalana de Recerca i Estudis Avancat, 

Univ. Paris Descartes - CNRS, Yale Univ. Sch. of Med. 

4:00 VV8 484.4 Visual response properties of a threelayered 

cortex explored in an eye-attached whole-brain 

preparation. M. S. CAUDILL*; M. ARIEL; R. WESSEL. 

Washington Univ. St Louis, St. Louis Univ. Sch. of Med. 

1:00 VV9 484.5 Response features of parvalbuminexpressing 

interneurons suggest precise roles for subtypes 

of inhibition in visual cortex. C. A. RUNYAN*; N. WILSON; J. 

SCHUMMERS; A. VAN WART; S. KUHLMAN; M. CARLEN; K. 

MELETIS; L. TSAI; Z. HUANG; M. SUR. MIT, Picower Inst. of 

Learning and Memory, Cold Spring Harbor Lab. 

2:00 VV10 484.6 Surround suppression in the owl visual 

wulst. A. TURCHETTI-MAIA*; J. BARON. ICB - Univ. Federal 

de Minas Gerais. 

3:00 VV11 484.7 • Stimulus-dependency of local field 

potential in surround interaction of primate V1. K. KIM*; T. 

KIM; C. LEE. Seoul Natl. Univ. 

4:00 VV12 484.8 A new role of surround interaction in V1 

neurons for discrimination of spatiotemporal sequence. T. 

YOON*; T. KIM; C. LEE. Seoul Natl. Univ. 

1:00 VV13 484.9 Temporal dynamics of surround 

suppression in two distinct populations of V1 neurons. F. 

BRIGGS*; W. M. USREY. Univ. California, Davis. 

2:00 VV14 484.10 Tuned mechanisms of contextual 

suppression: Linking physiology and psychophysics. C. A. 

HENRY*; M. J. HAWKEN. New York Univ. 

3:00 VV15 484.11 The arithmetic of spatial integration in 

visual cortex: Subtraction or division? A. AYAZ*; V. BONIN; M. 

CARANDINI. Univ. Col. London, Harvard Med. Sch. 

4:00 VV16 484.12 Development of orientation selectivity in 

the visual cortex. B. D. MOORE*, IV; R. D. FREEMAN. Univ. 


1:00 VV17 484.13 Nonlinear characterizations of simple and 

complex cells in V1. T. LOCHMANN*; T. BLANCHE; D. A. 

BUTTS. Univ. of Maryland, Helen Wills Neurosci. Inst. 

2:00 VV18 484.14 Quantitative relationship between neural 

population responses measured with voltage sensitive dye 

imaging and electrophysiology. E. J. SEIDEMANN*; C. 

PALMER; Y. CHEN. Univ. Texas At Austin, UC at San Diego. 

3:00 VV19 484.15 Getting drowsy? Alert/non-alert transitions 

and response properties in layer 4 of V1. J. ZHUANG*; Y. 

BERESHPOLOVA; C. STOELZEL; J. HUFF; J. ALONSO; 

H. A. SWADLOW. Univ. of Connecticut, SUNY State Col. of 

Optometry. 


Mon. PM

4:00 VV20 484.16 Getting drowsy? Alert/non-alert 

transitions and visual thalamocortical network dynamics. 

Y. I. BERESHPOLOVA*; C. R. STOELZEL; J. ZHUANG; Y. 

AMITAI; J. ALONSO; H. A. SWADLOW. Univ. of Connecticut, 

Ben Gurion Univ., SUNY - Col. of Optometry. 

1:00 WW1 484.17 Non-linearity of two-photon calcium 

imaging revealed using V1 contrast invariance. I. M. 

NAUHAUS*; K. J. NIELSEN; E. M. CALLAWAY. Salk Inst. 

2:00 WW2 484.18 Dynamic trajectories of area 17 neurons 

from different laminae. P. E. ROLAND*; M. A. HARVEY; L. 

FORSBERG. Karolinska Inst. 

3:00 WW3 484.19 Internal structure of receptive fields of 

nonlinear visual neurons revealed by Volterra analysis. M. 

FUKUI*; I. OHZAWA. Grad. Sch. of Frontier Biosciences, 

Osaka Univ., CREST, Japan Sci. and Technol. Agency. 

4:00 WW4 484.20 Complex cell receptive fields: Identifying 

the simple cells within. M. R. IBBOTSON*; J. VAN KLEEF; S. 

L. CLOHERTY. Australian Natl. Univ. 

1:00 WW5 484.21 • Visual stimulation-induced resetting of 

membrane voltage responses of V1 neurons in awake mice. 

G. MINAMISAWA*; N. MATSUKI; Y. IKEGAYA. The Univ. of 

Tokyo, PRESTO, Japan Sci. and Technol. Agency. 

2:00 WW6 484.22 Behavioral evidence for a privileged 

processing of the straight-ahead direction in Humans. J. 

DURAND; Y. TROTTER*; S. CELEBRINI. Cerco, UMR5549. 

3:00 WW7 484.23 Response properties to combination 

of two spectral components in A17,18 and V2 neurons. T. 

NAKAZONO*; M. ITO; K. ASAKAWA; I. OHZAWA. Grad. 

Sch. of Frontier Biosciences, Osaka Univ., Natl. Inst. for 

Physiological Sciences, The Grad. Univ. for Advanced 

Studies, The Jikei Univ. Sch. of Medicine,National Inst. for 

Physiological Sci., CREST, Japan Sci. and Technol. Agency. 

4:00 WW8 484.24 Orientation selectivity of membrane 

potential in mouse visual cortex neurons. A. Y. TAN*; B. D. 

BROWN; D. MOHANTY; N. J. PRIEBE. Univ. of Texas At 

Austin. 

1:00 WW9 484.25 Investigating the neural correlates 

of top-down influence using perceptual hysteresis. M. 

SUBRAMANIYAN*; A. TOLIAS. Baylor Col. of Med. 

POSTER 

485. Visual Cognition: Working and Short-Term Memory 



1:00 WW10 485.1 Monitoring of multiple features-location 

binding changes frontoparietal connectivity. S. TAKAHAMA*; 

I. OHZAWA; Y. YOSHIOKA; J. SAIKI. Osaka Univ., NiCT, 

CREST, Kyoto Univ. 

2:00 WW11 485.2 Oscillatory neuronal synchronization 

between prefrontal and extrastriate visual cortex during visual 

memory. S. LIEBE*; G. HOERZER; N. LOGOTHETIS; G. 

RAINER. MPI Biol. Cybernetics, Graz Univ. of Technol., Univ. 

of Fribourg. 

3:00 WW12 485.3 Dynamic change of neuronal population 

for integration of stimulus-stimulus and reward contingency 

signals in monkey perirhinal cortex. K. OHYAMA*; N. 

MATSUMOTO; M. SHIDARA; Y. SUGASE-MIYAMOTO. Univ. 

of Tsukuba, AIST, JSPS Res. fellow. 


4:00 WW13 485.4 Mental imagery serving action cognition 

includes visual in addition to the motor and kinesthetic 

components. M. KILINTARI*; V. RAOS; H. E. SAVAKI. 

FORTH/IACM, Univ. of Crete, Med. Sch. 

1:00 WW14 485.5 Activity of simultaneously recorded frontal 

eye field and inferotemporal neurons during object-based 

working memory. B. NOUDOOST; K. L. CLARK; T. MOORE*. 

Stanford Univ. Sch. of Med., Howard Hughes Med. Inst. 

2:00 WW15 485.6 Functional dissociation of visual short-term 

memory and multiple object tracking in human intraparietal 

sulcus. S. W. MICHALKA; S. L. SHEREMATA*; K. C. 

BETTENCOURT; M. L. ROSEN; D. C. SOMERS. Boston 

Univ., Massachusetts Gen. Hosp. 

3:00 WW16 485.7 Afterimages, iconic memory, and 

phenomenal visual consciousness. C. WU*. Perception and 

Cognition Resch Inst. 

4:00 WW17 485.8 The retention and disruption of color 

information in visual short term memory. V. A. NEMES*; N. R. 

A. PARRY; D. J. MCKEEFRY. Univ. of Bradford, Manchester 

Royal Eye Hosp. 

1:00 WW18 485.9 Content specificity of fronto-parietal 

coherence during visual working memory. N. M. DOTSON*; R. 

F. SALAZAR; C. M. GRAY. Montana State Univ. 

2:00 WW19 485.10 The role of persistent FEF activity 

in object-based working memory. K. L. CLARK*; B. 

NOUDOOST; T. MOORE. Stanford Univ. 

POSTER 

486. Eye Movements: Clinical and Normal Populations 



1:00 WW20 486.1 Hypoactivation in cortical/striatal areas 

is correlated to saccade impairments in ADHD. R. M. 

HAKVOORT SCHWERDTFEGER*; N. ALAHYANE; D. 

BRIEN; B. COE; P. W. STROMAN; D. P. MUNOZ. Queen’s 

Univ. 

2:00 XX1 486.2 Neural correlates of predictive saccades 

in young healthy adults. S. M. LEE*; D. BRIEN; B. COE; D. P. 

MUNOZ. Queen’s Univ. 

3:00 XX2 486.3 Deficits in orthogonal saccade production 

in parietal damaged patients. A. Z. KHAN*; A. BLANGERO; D. 

P. MUNOZ; L. PISELLA. Queen’s Univ., City Col. of New York, 

INSERM 864. 

4:00 XX3 486.4 Quickness of saccades and the daily 

amount of computer games. U. ILG*; D. MACK. Hertie- 

Institute. 

1:00 XX4 486.5 Predictive saccades can drive adaptation: 

Learning with an impaired cerebellum. A. L. WONG*; M. 

SHELHAMER. Johns Hopkins Univ. Sch. Med. 

2:00 XX5 486.6 Interaction between smooth and saccadic 

eye movements during visual tracking in children. C. EGO*; 

M. NASSOGNE; D. YUKSEL; P. LEFEVRE. Univ. catholique 

de Louvain, Cliniques universitaires Saint-Luc. 

3:00 XX6 486.7 Changing your mind: Cerebellar disorders 

and the double-step saccade task. S. A. D. KING; A. L. CHEN; 

A. C. JOSHI; G. NAASSAN; R. LEIGH*. Va Med. Ctr., Case 

Western Reserve Univ., Case Med. Ctr. 



4:00 XX7 486.8 Investigating cognitive deficits in 

amyotrophic lateral sclerosis using eye movements and 

fMRI. K. L. WITIUK*; R. MCKEE; N. ALAHYANE; B. COE; D. 

BRIEN; M. MELANSON; D. P. MUNOZ. Queen’s Univ. 

1:00 XX8 486.9 Saccade performance in healthy aging 

assessed with structural and functional MRI. A. J. PELTSCH*; 

D. C. BRIEN; N. ALAHYANE; B. C. COE; A. GARCIA; D. P. 

MUNOZ. Queen’s Univ. 

2:00 XX9 486.10 Influence of early Parkinson’s disease and 

aging on anticipatory smooth pursuit. C. DE HEMPTINNE*; 

A. IVANOIU; P. LEFÈVRE; M. MISSAL. Univ. Catholique de 

Louvain. 

3:00 XX10 486.11 Nicotinic effects on motor and learning 

functions as measured by eyetracking and associated brain 

activations. E. HONG*. Maryland Psychiatric Res. Ctr. 

4:00 XX11 486.12 • Handheld cellular phones restrict range 

of spontaneous visual regard. Z. C. THUMSER*; J. S. STAHL. 

Louis Stokes Cleveland Dept Veterans Affairs Med. Ctr., Louis 

Stokes Cleveland VAMC, Case Western Reserve Univ. 

1:00 XX12 486.13 MRI demonstrates the anatomic basis 

of oculomotor deficits in normal aging. C. H. JUNG; T. C. 

LEVEY; A. X. DU; J. L. CUZZOCREO; R. W. BALOH; S. L. 

PERLMAN; J. L. PRINCE; A. W. TOGA; H. S. YING*; S. H. 

YING. Johns Hopkins Univ., UCLA, Johns Hopkins Hosp. 

POSTER 

487. Pain Imaging and Perception 



1:00 XX13 487.1 Associations between serotonin 

transporter gene (SLC6A4) polymorphisms and emotional 

modulation of pain and nociception. S. PALIT*; R. 

HOFFMANN; R. J. SHEAFF; S. MCGLONE; C. R. FRANCE; 

W. POTTER; A. HARKNESS; J. MCNULTY; E. J. BARTLEY; 

J. K. MONDA; J. L. RHUDY. Univ. of Tulsa, Ohio Univ. 

2:00 XX14 487.2 Emotional modulation of pain and 

nociception in fibromyalgia and rheumatoid arthritis: 

Preliminary findings. J. L. DELVENTURA*; E. TERRY; E. J. 

BARTLEY; A. VINCENT; E. OLECH; J. L. RHUDY. The Univ. 

of Tulsa, Univ. of Oklahoma Hlth. Sci. Ctr. 

3:00 XX15 487.3 Is anxiety sensitivity associated with 

temporal summation of pain and nociception? K. L. KERR*; E. 

L. TERRY; E. J. BARTLEY; J. DELVENTURA; A. VINCENT; J. 

L. RHUDY. Univ. of Tulsa. 

4:00 XX16 487.4 Can beliefs about oxytocin’s prosocial 

effects induce a rewarding ”placebo effect” on perceived touch 

hedonics? S. LEKNES*; D. ELLINGSEN; J. LILJENCRANTZ; 

J. WESSBERG; H. OLAUSSON. Univ. Oslo, Univ. 

Gothenburg. 

1:00 XX17 487.5 Interoceptive cortical thickness correlates 

with pain-related personality factors. Q. WU*; M. MOAYEDI; 

U. BLANKSTEIN; K. S. TAYLOR; J. CHEN; I. WEISSMAN- 

FOGEL; M. HODAIE; K. D. DAVIS. Toronto Western Res. 

Inst., Univ. of Toronto, Toronto Western Hosp. 

2:00 XX18 487.6 Dissociated states in fibromyalgia patients 

during sleep: An exploratory study using EEG mapping. T. F. 

OLIVEIRA*; L. FERREIRA; J. M. R. SANCHES; T. PAIVA. 

ISPA - Inst. Universitário, Faculdade de Medicina da Univ. de 

Lisboa, Ctr. de Electroencefalografia e Neurofisiologia Clínica, 

Inst. Superior Técnico, UTL. 



3:00 XX19 487.7 1 H-mrs cortical measurements in chronic 

low back pain. N. K. SHARMA*; K. MCCARSON; L. VAN 

DILLEN; W. BROOKS; T. KHAN; S. WILSON; A. BANI- 

AHMED; C. CIRSTEA. Univ. Kansas Med. Ctr., Washington 

Univ., Univ. of Kansas. 

4:00 XX20 487.8 Nociceptive steady-state laser-evoked 

brain potentials. A. MOURAUX; G. IANNETTI*; L. PLAGHKI. 

Univ. catholique de Louvain, Univ. Col. London. 

1:00 YY1 487.9 Investigating the motor component of pain 

with fMRI. I. PERINI*; S. BERGSTRAND; H. OLAUSSON; I. 

MORRISON. Sahlgrenska Univ. Hosp. 

2:00 YY2 487.10 Differences in gamma oscillatory 

dynamics between visceral and somatic pain found using 

magnetoencephalography. H. ROSSITER*; S. WORTHEN; P. 

FURLONG. Aston Univ. 

3:00 YY3 487.11 Assessing hyperexcitability of spinal 

nociceptive processes in humans: Refining methods for 

temporal summation of the nociceptive flexion reflex. E. L. 

TERRY*; E. J. BARTLEY; J. DELVENTURA; K. KERR; A. 

VINCENT; C. R. FRANCE; J. L. RHUDY. Univ. of Tulsa, Ohio 

Univ. 

4:00 YY4 487.12 • Individual differences in emotional 

modulation of pain are associated with individual differences 

in pain sensitivity: A menstrual cycle study. E. J. BARTLEY*; J. 

L. RHUDY. The Univ. of Tulsa. 

1:00 YY5 487.13 Pain catastrophizing is related to temporal 

summation of pain, but not temporal summation of spinal 

nociceptive processes. S. L. MARTIN*; E. TERRY; E. J. 

BARTLEY; J. L. DELVENTURA; A. VINCENT; K. L. KERR; C. 

R. FRANCE; J. L. RHUDY. The Univ. of Tulsa, Ohio Univ. 

2:00 YY6 487.14 Pediatric pain assessment using near 

infrared spectroscopy. M. IZZETOGLU*; H. ROSEN; M. 

RODRIGUEZ; K. POURREZAEI; A. ROSEN. Drexel Univ., 

Onsite Neonatal Partners Inc. 

3:00 YY7 487.15 Hemodynamic and light scattering 

changes of the spinal cord and primary somatosensory cortex 

in responses to innocuous and noxious stimuli. J. W. HE*; S. 

NARVENKAR; V. SHARMA; H. LIU; Y. B. PENG. Univ. Texas 

-Arlington, Univ. of Texas at Arlington. 

4:00 YY8 487.16 Pain circuits in the infant brain: Mn2+ 

enhanced MRI imaging in the infant rat. G. A. BARR*; N. J. 

TUSTISON; J. C. GEE. Children’s Hosp. of Philadelphia, Univ. 

of Pennsylvania. 

1:00 YY9 487.17 Neural substrates of empathy for pain: 

Simultaneous recordings of high density EEG and autonomic 

reactions. Y. MOTOYAMA*; K. OGATA; S. HOKA; S. 

TOBIMATSU. Grad Sch. Med. Sci, Kyushu Univ. 

2:00 YY10 487.18 In vivo visualization of the trigeminal nerve 

using diffusion-based tractography in secondary trigeminal 

neuralgia: A case report. D. D. DESOUZA*; D. Q. CHEN; 

K. D. DAVIS; M. HODAIE. Toronto Western Hosp., Univ. of 

Toronto, Toronto Western Res. Inst. 

POSTER 

488. Neuropathic Pain: Glia 



1:00 ZZ1 488.1 PPAR and gamma; agonist rosiglitazone 

attenuates the development of neuropathic pain by regulating 

macrophage activation. Y. TAKAHASHI*; M. HASEGAWA; E. 

INADA; T. SAKURAI. Juntendo Univ. 


Mon. PM

2:00 ZZ2 488.2 • Microglial hyperactivation in rat trigeminal 

spinal subnucleus caudalis is involved in extraterritorial 

trigeminal neuropathic pain mechanisms. K. SHIBUTA*; I. 

SUZUKI; Y. TSUBOI; N. SHIMIZU; K. IWATA. Nihon Univ. 

Sch. of Dent. 

3:00 ZZ3 488.3 Morphological analysis of microglia in the 

intact mouse spinal cord using two-photon microscopy. S. A. 

BEGGS*; G. M. PITCHER; J. LEUNG; M. W. SALTER. Hosp. 

for Sick Children, Univ. of Toronto Ctr. for the Study of Pain. 

4:00 ZZ4 488.4 Satellite glial cell division following nerve 

injury. L. JASMIN; M. KERNISANT; A. BHARGAVA; P. T. 

OHARA*. Univ. California San Francisco. 

1:00 ZZ5 488.5 The roles of TNFα and IL-1β in the 

antiretroviral drug-induced sensory neuropathic pain. X. 

ZHENG*; H. OUYANG; S. LIU; M. MATA; D. FINK; S. HAO. 

Univ. of Michigan. 

2:00 ZZ6 488.6 Lidocane attenuates the development of 

diabetes-induced tactile allodynia by inhibiting macrophage 

activation. N. SUZUKI*; M. HASEGAWA-MORIYAMA; Y. 

KAMIKUBO; K. KIMURA; T. SAKURAI; E. INADA. Tokyo 

Metropolitan Cancer and Infectious Dis. Ctr. Komagome 

Hosp., Juntendo Univ. Grad. Sch. of Med., Juntendo Univ. 

Fac. of Med. 

3:00 ZZ7 488.7 • Glial activation and blood brain barrier 

permeability following repeated dural stimulation. M. L. 

OSHINSKY*; C. R. MAXWELL. Thomas Jefferson Univ. 

4:00 ZZ8 488.8 Glial activation in the medullary dorsal 

horn mediates cancer-induced pain in a rat facial cancer 

model. N. HARANO*; K. ONO; K. HIDAKA; O. NAKANISHI; 

K. INENAGA. Kyusyu Dent. Col., Kyushu Dent. Col. 

1:00 ZZ9 488.9 � Persistence of glial activation at 3 months 

post injury in several experimental models of neuropathic 

pain. Y. WU*; S. ECHEVERRY; K. BACHAND; M. PERALTA; 

X. Q. SHI; Y. Q. ZHAO; A. GODIN; Y. DE KONINCK; J. 

ZHANG. The Alan Edwards Ctr. for Res. on Pain, McGill Univ., 

Univ. Laval. 

2:00 ZZ10 488.10 The distinctive response of CNS glial 

cells in oro-facial pain associated with injury, infection and 

inflammation. S. LEE*; Y. ZHAO; A. RIBEIRO-DA-SILVA; J. 

ZHANG. McGill Univ. 

3:00 AAA1 488.11 Uncovering the interaction between 

astrocyte calcium dynamics, dorsal horn synaptic activity, and 

nociception. S. KURTZER-MINTON*; K. D. MCCARTHY. Univ. 

of North Carolina-Chapel Hill. 

4:00 AAA2 488.12 Toll-like receptor 3 contributes to 

neuropathic pain. J. A. STOKES*; M. CORR; T. L. YAKSH. 

UCSD. 

1:00 AAA3 488.13 Expression and phosphorylation of ERM 

family proteins in rat spinal dorsal horn following peripheral 

nerve injury. R. KASHIMOTO; H. YAMANAKA; M. OKUBO; 

K. KOBAYASHI*; O. MIMURA; K. NOGUCHI. Hyogo Col. of 

Med. 

2:00 AAA4 488.14 Increased cytokine signalings in a model 

of HIV coat protein gp120-related peripheral neuropathy. W. 

ZHENG*; H. OUYANG; S. LIU; M. MATA; D. FINK; S. HAO. 


3:00 AAA5 488.15 The oATP interacts with reactive gliosis in 

neuropathic pain rat model. V. PETROSINO; G. CIRILLO; M. 

BIANCO; S. SELLITTI; A. COLANGELO; L. ALBERGHINA; 

M. PAPA*. Anatomia Umana Normale Seconda Universita’ 

Di Napoli, Lab. di Neuroscienze “R. Levi-Montalcini” Dept. 

di Biotecnologie e Bioscienze, Ed. U4-5055 Univ. di Milano- 

Bicocca. 


4:00 AAA6 488.16 Reactive gliosis and calcium dynamics 

in spinal cord. G. CIRILLO*; D. DE LUCA; M. BIANCO; M. 

PAPA. Second Univ. of Naples. 

1:00 AAA7 488.17 Involvement of cathepsin S in painful 

diabetic neuropathy. T. MIXCOATL-ZECUATL*; S. A. 

DALRYMPLE; N. A. CALCUTT. Univ. of California San Diego, 

Virobay, Inc. 

2:00 AAA8 488.18 Lysophosphatidic acid and neuropathic 

pain - Involvement of microglia activation. J. NAGAI*; L. MA; 

H. UEDA. Nagasaki Univ. Grad. Sch. of Biomed. Sci. 

3:00 AAA9 488.19 The effects of conditioned Schwann cell 

media on capsaicin-stimulated release of calcitonin-gene 

related peptide from sensory neurons. R. M. MEADOWS*; C. 

M. HINGTGEN. Indiana Univ. Sch. of Med. 

POSTER 

489. Rhythmic Motor Pattern Cellular Properties: Invertebrate 

and Theory 



1:00 AAA10 489.1 Mechanisms of hypoxia sensing by 

Lymnaea central respiratory neurons. T. JANES; F. XU; N. 

WONG; N. I. SYED*. Univ. Calgary. 

2:00 AAA11 489.2 Variability in an ongoing motor pattern: 

Blood flow in individual leeches. A. WENNING*; A. DOLOC 

MIHU; R. L. CALABRESE. Emory Univ. 

3:00 AAA12 489.3 Do changes in the phasing of a welldefined 

central pattern generator lead to corresponding 

changes in the motor output? B. J. NORRIS*; A. WENNING; 

R. L. CALABRESE. California State Univ., Emory Univ. 

4:00 AAA13 489.4 Contribution of intrinsic properties to 

the input-output relationship of leech heart motor neurons 

evaluated with a multi-compartmental model. D. G. 

LAMB*; T. M. WRIGHT; A. WENNING; B. J. NORRIS; R. L. 

CALABRESE. Emory Univ., California State Univ. 

1:00 AAA14 489.5 The contribution of electrical coupling and 

spatiotemporal patterns to coordinated motor output. T. M. 

WRIGHT*, Jr.; R. L. CALABRESE. Emory Univ. 

2:00 AAA15 489.6 Mechanisms for behavioral choice 

between a whole body and a local behavior in the medicinal 

leech. C. R. PALMER*; W. B. KRISTAN, Jr. UCSD. 

3:00 AAA16 489.7 What we talk about when we talk about 

capacitance measured in voltage clamp. A. L. TAYLOR*; E. 

MARDER. Brandeis Univ. 

4:00 AAA17 489.8 Morphology of a stomatogastric neuron. 

M. GOERITZ*; R. GRASHOW; T. BROOKINGS; E. MARDER. 

Brandeis Univ. 

1:00 AAA18 489.9 Linking neuronal properties, cell identity, 

and network activity. T. BROOKINGS*; R. GRASHOW; E. 

MARDER. Brandeis Univ. 

2:00 AAA19 489.10 The effects of the Ionic currents covariation 

on the rhythmic activity patterns. S. ZHAO*; J. 

GOLOWASCH. NJIT. 

3:00 AAA20 489.11 Probing homeostatic compensation using 

temperature perturbations: From channel transcription to 

network output. L. S. TANG*; M. GOERITZ; E. MARDER. 

Brandeis Univ. 



4:00 AAA21 489.12 The frequency-dependent response of 

synapse in an oscillatory network. H. TSENG*; F. NADIM. 

Rutgers, The State Univ. of New Jersey, NJIT. 

1:00 AAA22 489.13 • GABAergic control of locomotion and 

coordination in Drosophila larvae. S. R. PULVER*; J. FOX; J. 

ZHANG; Y. CHANG; M. BATE; G. E. STILWELL. Cambridge 

Univ., Cambria Biosci., St. Joseph’s Hosp. and Med. Ctr., 


2:00 BBB1 489.14 Multi-neuronal innervation of a muscle 

by four excitatory neurons - Innervation pattern and temporal 

dynamics. C. STAEDELE; W. STEIN*. Ulm Univ., Univ. Ulm. 

3:00 BBB2 489.15 An inter-segmental network model and its 

use in elucidating smooth dynamic gait switches. S. GRUHN*; 

T. I. TOTH. Emmy-Noether Nachwuchsgruppe, Zoologisches 

Institut, Univ. zu Köln. 

POSTER 

490. Rhythmic Pattern Generation Cellular Properties: 

Vertebrate 



1:00 BBB3 490.1 Kinematic strokes and ‘words’ of motor 

primitive sequences: Relating kinematic and motor pattern 

modularity. C. B. HART*; S. F. GISZTER. Drexel Univ. Coll 

Med. 

2:00 BBB4 490.2 Premotor drive pulses as modular 

primitives shared in both spinal reflexes and voluntary frog 

prey strike behavior. T. GULATI*; J. A. MONROY; T. A. 

UYENO; K. C. NISHIKAWA; C. B. HART; S. F. GISZTER. 

Drexel Univ. Col. of Med., Northern Arizona Univ. 

3:00 BBB5 490.3 Activity dependent control of locomotion 

via up-regulation of the Na+/K+ exchange pump. H. ZHANG*; 

K. T. SILLAR. Univ. of St. Andrews. 

4:00 BBB6 490.4 Vocal rhythm generation using efferent 

copy in African clawed frog. A. YAMAGUCHI*; E. ZORNIK; K. 

WILLIAMS. Boston Univ., Univ. of Utah. 

1:00 BBB7 490.5 Synaptic and cellular basis of temporal 

vocal patterns in the frog, Xenopus laevis. E. ZORNIK*; A. W. 

KATZEN; H. J. RHODES; H. J. YU; A. YAMAGUCHI. Boston 

Univ., Denison Univ. 

2:00 BBB8 490.6 The development of a locomotor rheostat 

in Xenopus laevis larvae. K. T. SILLAR*; H. ZHANG. Univ. St 

Andrews. 

3:00 BBB9 490.7 The impact of localized Ca2+ entry in 

lamprey spinal neurons on CPG output. M. H. ALPERT*; S. T. 

ALFORD. Univ. of Illinois, Chicago. 

4:00 BBB10 490.8 Subpopulations of cerebrospinal fluidcontacting 

cells in the lamprey spinal cord have neuronal 

properties and different immunohistochemical and 

morphological characteristics. E. JALALVAND; R. H. HILL*; P. 

WALLÉN; S. GRILLNER. Karolinska Inst. 

1:00 BBB11 490.9 Embryonic nicotine exposure and its effect 

on adult locomotor behavior analyzed in freely swimming 

zebrafish. E. MENELAOU*; K. R. SVOBODA. LSU. 

2:00 BBB12 490.10 Conversion of walking to swimming 

spinal circuitry by motor neuron subtype specification. W. 

A. ALAYNICK*; B. W. GALLARDA; T. O. SHARPEE; S. L. 

PFAFF. The Salk Inst. For Biol. Studies`. 



3:00 BBB13 490.11 Large-scale calcium imaging of rhythmic 

activity in mouse spinal interneurons. A. C. KWAN*; S. B. 

DIETZ; G. ZHONG; R. M. HARRIS-WARRICK; W. W. WEBB. 

Univ. California Berkeley, Cornell Univ. 

4:00 BBB14 490.12 Frequency-dependent activation of V2a 

interneurons during fictive locomotion in the mouse spinal 

cord. G. ZHONG; R. M. HARRIS-WARRICK*. Cornell Univ. 

1:00 BBB15 490.13 Developmental divergence of intrinsic 

firing properties among spinal V1 interneurons. P. M. 

SONNER*; F. J. ALVAREZ. Wright State Univ. 

2:00 BBB16 490.14 Functional characterization of geneticallydefined 

interneurons located in lamina VIII of the mammalian 

spinal cord. J. DYCK; B. PANAITESCU; G. LANUZA; K. 

BALLANYI; S. GOSGNACH*. Univ. Alberta, Fundacion Inst. 

Leloir. 

3:00 BBB17 490.15 Characterization of dI6 neuronal subtypes 

in the spinal cord. L. GARCIA-CAMPMANY*; A. GIRAUDIN; 

T. HENDRICKS; A. VALLSTEDT; L. ZAGORAIOU; K. 

KULLANDER; T. JESSELL. The Salk Inst. For Biol. Studies, 

Uppsala Univ., Howard Hughes Med. Institute, Kavli Inst. of 

Brain Sci. 

4:00 BBB18 490.16 Intrinsic and synaptic properties of 

identified mouse propriospinal neurons. J. R. FLYNN*; R. J. 

CALLISTER; A. M. BRICHTA; M. P. GALEA; B. A. GRAHAM. 

Univ. of Newcastle, Univ. of Melbourne. 

1:00 BBB19 490.17 Effects of blocking the endoplasmic 

reticulum Ca2+ pump on respiratory rhythm in vitro. C. 

MORGADO-VALLE*; M. L. LOPEZ-MERAZ; C. A. PEREZ- 

ESTUDILLO; L. BELTRAN-PARRAZAL. Programa De 

Neurobiologia, Univ. Veracruzana. 

2:00 BBB20 490.18 Neuronal mechanisms generating 

electrical stimulation-evoked rhythmic burst activity in the 

trigeminal nerve of neonatal mice in vitro. K. NAKAYAMA; Y. 

IHARA; T. INOUE*. Showa Univ. Sch. of Dent. 

3:00 BBB21 490.19 Properties of nicotinic acetylcholine 

receptors expressed on developing hypoglossal motoneurons 

following prolonged nicotinic receptor stimulation. J. Q. 

PILARSKI*; H. E. WAKEFIELD; A. J. FUGLEVAND; R. B. 

LEVINE; R. F. FREGOSI. Univ. Arizona. 

4:00 BBB22 490.20 An experimental and modeling study of 

the resonance properties of GABAergic inhibitory brainstem 

interneurons. J. F. VAN BREDERODE*; A. J. BERGER. Univ. 

Washington. 

1:00 CCC1 490.21 • Distribution patterns of cortico-cortical 

and thalamo-cortical inputs to parvalbumin-expressing 

GABAergic neurons in rat frontal cortex. N. SHIGEMATSU*; Y. 

KUBOTA; Y. KAWAGUCHI. NIPS, JST, CREST. 

POSTER 

491. Basal Ganglia: Neurotransmitters 



1:00 CCC2 491.1 Erk1 and Erk2 kinases involved in 

D1-dopamine receptor mediated signaling in the lesioned 

striatum. R. F. PALETZKI*; C. R. GERFEN. NIMH/NIH. 

2:00 CCC3 491.2 • NMDA receptor subunit expression in the 

subthalamic nucleus. H. YUAN*; K. M. VANCE; F. SOTTY; K. 

FOG; Y. SMITH; S. F. TRAYNELIS. Emory Univ. Sch. Med., 

Discovery Pharmacol. Res. 


Mon. PM

3:00 CCC4 491.3 Extracellular amino acid responses to 

motivation and learning, detected by capillary electrophoresiscoupled 

in vivo microdialysis in the medial striatum of 

domestic chicks. G. ZACHAR; T. TABI; Z. WAGNER; E. 

BALINT; E. SZOKO; A. CSILLAG*. Semmelweis Univ. Med. 

4:00 CCC5 491.4 Fos expression in a projection from the 

rostromedial tegmental nucleus (RMTg) to the pars dissipata 

of the pedunculopontine tegmental nucleus (PPTg) following 

administration of methamphetamine in the rat. H. N. LAVEZZI; 

K. P. PARSLEY; M. ARIEL*; D. S. ZAHM. St. Louis Univ. Sch. 

of Med. 

1:00 CCC6 491.5 The effects of tacrine and caffeine on 

c-Fos expression in the basal ganglia. K. KOPPITCH; L. 

MEHR; J. PANDO; J. JOHNSON; N. PATEL; J. T. TREVITT*. 

California State Univ, Fullerton. 

2:00 CCC7 491.6 Presynaptic modulation of bidirectional 

GABAergic plasticity at susbstantia nigra pars reticulata, a 

possible switch between direct and indirect pathways. P. E. 

RUEDA-OROZCO*; J. J. ACEVES; R. HERNANDEZ; E. 

GALARRAGA; J. BARGAS. Inst. de Fisiología Celular, UNAM. 

3:00 CCC8 491.7 Somatostatinergic modulation of lateral 

inhibition is altered in an animal model of Parkinson’s disease. 

V. G. LOPEZ-HUERTA; J. BARGAS*; E. GALARRAGA. Inst. 

Fisiologia Celular. 

4:00 CCC9 491.8 Cannabinoid CB 1 receptor activation is 

not involved in the locomotor activation induced by adenosine 

A 2A receptor antagonists. C. QUIROZ; M. ORRU; C. W. 

SCHINDLER*; Z. JUSTINOVA; S. GOLDBERG; S. FERRÉ. 

DHHS/NIH/NIDA Intramural Res. 

1:00 CCC10 491.9 Receptor heteromerization determines the 

striatal pre- and postsynaptic profile of adenosine A 2A receptor 

antagonists. M. ORRU; J. BAKESOVA; M. BRUGAROLAS; 

C. R. QUIROZ*; V. BEAUMONT; E. CANELA; A. CORTES; R. 

FRANCO; V. CASADO; C. LLUIS; S. FERRE. NIDA, IRP, NIH, 

DHHS, Univ. of Barcelona, CHDI Mgmt. 

2:00 CCC11 491.10 Molecular mechanism of crf action 

in nucleus accumbens neurons. C. M. STERN*; P. G. 

MERMELSTEIN. Univ. of Minnesota. 

3:00 CCC12 491.11 Group II metabotropic glutamate receptor 

activation induces long-term depression of excitatory 

transmission in the substantia nigra pars reticulata. K. A. 

JOHNSON*; D. J. SHEFFLER; C. M. NISWENDER; Z. 

XIANG; P. J. CONN. Vanderbilt Univ. 

4:00 CCC13 491.12 β1-adrenergic receptors activate two 

distinct signaling pathways in striatal neurons. J. MEITZEN*; 

J. I. LUOMA; C. M. STERN; P. G. MERMELSTEIN. Univ. of 

Minnesota. 

1:00 CCC14 491.13 Investigating the effects of lesions of 

the cholinergic mesopontine tegmentum on the locomotor 

response to nicotine. D. A. MACLAREN*; D. I. G. WILSON; 

N. W. SCOTT; P. WINN. Univ. of St Andrews, Univ. of 

Strathclyde. 

2:00 CCC15 491.14 • Immunocytochemical localization 

of enkephalin in the human striatum, a postmortem 

ultrastructural study. L. A. BRYANT*; J. K. ROCHE; R. C. 

ROBERTS. Univ. Alabama, Birmingham. 

3:00 CCC16 491.15 5-HT transporter blockade reduces 

nigrostriatal dopamine signaling through 5-HT2C receptor 

activation to impair basal ganglia function in mice. E. 

MORELLI*; M. S. ANSORGE; J. A. GINGRICH. Columbia 

Univ. 


4:00 CCC17 491.16 Modulation of extracellular dopamine 

levels in the striatum by transcranial direct current stimulation. 

T. TANAKA*; Y. TAKANO; S. TANAKA; K. WATANABE; 

T. HANAKAWA; M. HONDA; N. HIRONAKA. Natl. Inst. of 

Neuroscience, Natl. Ctr. of Neurol. and Psychiatry, JST, 

ERATO, SHIMOJO Implicit Brain Function Project, Tokyo 

Med. and Dent. Univ. Grad. Sch., JST, PRESTO. 

1:00 CCC18 491.17 Functional connections made by dorsal 

striatum medium spiny neurons and their modulation by 

dopamine in conditional channelrhodopsin 2 transgenic mice. 

N. CHUHMA*; K. TANAKA; R. HEN; S. RAYPORT. Columbia 

Univ., NYS Psychiatric Inst., Natl. Inst. of Physiological Sci., 

columbia Univ. 

2:00 CCC19 491.18 Distribution and ultrastructural features 

of the serotonin innervation of subthalamic nucleus in the 

rat and the squirrel monkey. M. PARENT*; M. WALLMAN; L. 

DESCARRIES. Univ. Laval, Univ. de Montréal. 

3:00 CCC20 491.19 Different involvement of cannabinoid 

system depending on stimulus intensity in ethanol-induced 

corticostriatal synaptic depression. H. CHO*; S. JEUN; Q. LI; 

S. CHOI; K. KIM; K. SUNG. Catholic Univ, Korea. 

4:00 CCC21 491.20 GPR88 - A putative G protein-coupled 

receptor highly expressed in the striatum: Cellular localization 

and developmental regulation. V. VAN WAES*; K. Y. TSENG; 

H. STEINER. RFUMS/The Chicago Med. Sch. 

1:00 CCC22 491.21 • Effects of inhibition of phosphodiesterase 

10A on motor behavior and brain metabolic activity in 

monkeys. S. UTHAYATHAS; J. G. MASILAMONI; F. S. 

MENNITI; C. J. SCHMIDT*; Y. SMITH; T. WICHMANN; S. M. 

PAPA. Emory Univ., cyclicM LLC, Pfizer Global Res. & Dev. 

2:00 DDD1 491.22 Collateralization of subiculum projections 

to the lateral septum, accumbens, bed nucleus of stria 

terminalis and central nucleus of the amygdala. M. L. 

BECKER; K. P. PARSLEY*; C. W. GHOBADI; D. S. ZAHM. St. 

Louis Univ. Sch. of Med. 

3:00 DDD2 491.23 Afferents of the retrobrubral field and 

rostral ventrolateral periaqueductal gray in relation to those 

of the ventral tegmental area and substantia nigra in the rat. 

C. GRUBER; S. GEISLER*; K. P. PARSLEY; T. J. LEE; C. W. 

GHOBADI; A. Y. CHENG; R. W. VEH; D. S. ZAHM. Charité 

Universitätsmedizin, St. Louis Univ. Sch. of Med. 

4:00 DDD3 491.24 • Effects on singing behavior of 

dopaminergic drug infusion in the basal ganglia of songbirds. 

A. LEBLOIS*; D. J. PERKEL. CNRS / Univ. René Descartes, 

Univ. of Washington. 

1:00 DDD4 491.25 Retrograde tracing and 

immunohistochemical identification of SP and NF in vagal 

afferent neurons in the mouse. S. BALENTOVA*; M. 

ADAMKOV; A. C. MYERS. Jessenius Fac. of Med. In Martin, 

Comenius Univ., The Johns Hopkins Sch. of Medicine, Johns 

Hopkins Univ. 

2:00 DDD5 491.26 Alterations of behavioral and dopamine 

activities by the high frequency stimulation of the subthalamic 

nucleus in freely moveable hemi-parkinsonian models with 

potable deep brain stimulator. Y. HWANG*; S. PARK; J. OH; Y. 

KIM; Y. PARK; S. KIM; Z. CHO; J. CHANG. Yonsei Univ. Coll. 

of Med., Inst. of Interventional Medicine, M.I.Tech Co., Ltd., 

Gachon Univ., Coll. of Med. and science, Seoul Nat’l Univ. 



POSTER 

492. Voluntary Reaching: Movement Selection and Strategy 



1:00 DDD6 492.1 Investigating control strategies in force 

regulation tasks. M. KOLESNIKOV*; M. CASADIO; K. M. 

LYNCH; F. A. MUSSA-IVALDI. Rehabil. Inst. of Chicago, 


2:00 DDD7 492.2 Measurement of arm impedance during 

robot therapy. D. PIOVESAN*; M. CASADIO; P. MORASSO; 

F. A. MUSSA-IVALDI. Northwestern Univ., Rehabil. Inst. of 

Chicago, Univ. of Genova, Italian Inst. of Technol. 

3:00 DDD8 492.3 Collaboration in virtual environments: 

The role of Fitts’ law in describing complex human-computer 

interaction. P. GRABOWSKI; A. RUTHERFORD; A. H. 

MASON*. Univ. of Wisconsin - Madison. 

4:00 DDD9 492.4 Optimal motor behavior in a nonlinear 

‘cliff-walking’ task. A. A. AHMED*; M. S. BERNIKER. Univ. 

Colorado, Northwestern University, Rehabil. Inst. of Chicago. 

1:00 DDD10 492.5 Reaching and grasping: Predictive control 

in children with DCD. P. VISWANATHAN; F. A. KAGERER*; 

J. WHITALL. Univ. of Maryland Sch. of Med., Michigan State 

Univ. 

2:00 EEE1 492.6 Can sensorimotor behavior be predicted 

by linear quadratic control? J. J. TRAMPER*; B. VAN DEN 

BROEK; W. A. J. J. WIEGERINCK; H. J. KAPPEN; C. C. A. M. 

GIELEN. Radboud Univ. 

3:00 EEE2 492.7 • Motor task difficulty and brain activity: 

Investigation of the wolf motor function test using near-infrared 

spectroscopy. T. KURAYAMA*; T. YAMAGUCHI; Z. KOMIYA; 

Y. OTAKA; K. TAKEDA; R. OSU; T. SHIGEO; K. KONDO; D. 

MATSUZAWA; E. SHIMIZU. Tokyo Bay Rehabil. Hosp., Grad. 

Sch. of Medicine, Chiba Univ., Grad. Sch. of Medicine, Keio 

Univ., Res. Fellowships of the Japan Society for the Promotion 

of Sci., ATR Computat. Neurosci. Labs., Fujita Hlth. Univ. 

4:00 EEE3 492.8 • A simple model of upper extremity 

reaching control, which accounts for lateralization of the 

motor system. T. TOMLINSON*; R. L. SAINBURG. The 

Pennsylvania State Univ. 

1:00 EEE4 492.9 Rapid reaching task ‘points’ toward 

different representations of number. C. S. CHAPMAN*; J. P. 

GALLIVAN; D. K. WOOD; J. L. MILNE; J. C. CULHAM; D. 

ANSARI; M. A. GOODALE. Univ. of Western Ontario. 

2:00 EEE5 492.10 Reaching beyond arm’s length: An EMG 

analysis using support vector machines. E. THOMAS*; A. 

TOLAMBIYA; B. BERRET; T. POZZZO. Univ. De Bourgogne, 

Italian Inst. of Technol. 

3:00 EEE6 492.11 Relevance of stop signal presence on 

preparation and execution of arm reaching movements in DBS 

Parkinson‘s patients. G. B. MIRABELLA*; S. IACONELLI; 

N. MODUGNO; P. ROMANELLI; S. SPADACENTA; M. 

MANFREDI; G. CANTORE. Univ., IRCCS Neuromed. 

4:00 EEE7 492.12 Ipsilateral muscle activity in the upper limb 

revealed by EMG following motor cortical stimulation using 

stimulus trains. L. R. MONTGOMERY*; S. L. MORAN; W. J. 

HERBERT; J. A. BUFORD. The Ohio State Univ. 

1:00 EEE8 492.13 Control of unconstrained arm movement 

during planar stroke production. W. WANG*; N. DOUNSKAIA. 




2:00 EEE9 492.14 The control of multiple movement 

segments in a foot aiming task. J. NO*; Y. SONG; Y. KIM; J. 

PARK. Jin-Hoon Park. 

3:00 EEE10 492.15 Hand preference depends on motor 

performance asymmetries in dynamic efficiency. C. J. 

COELHO*; S. AKPINAR; D. A. ROSENBAUM; R. L. 

SAINBURG. Penn State Univ., Middle East Tech. Univ. 

4:00 FFF1 492.16 On three dimensional reaching 

movements under obstacle conditions. B. CZECH; J. 

LIPINSKI; G. SCHONER*. Ruhr-Univ. Bochum. 

1:00 FFF2 492.17 Infinite horizon optimal control framework 

for goal directed movements. D. HUH*; E. TODOROV; T. 

SEJNOWSKI. Salk Inst., UCSD, Univ. of Washington. 

2:00 FFF3 492.18 • Relative importance of intended 

hand use versus target location for muscle synergies that 

transport the hand during reaching to grasp. S. GEED; M. L. 

MCCURDY; P. L. VAN KAN*. Univ. Wisconsin. 

3:00 FFF4 492.19 Movement precision is the same at the 

shoulder and elbow joints. A. KARDUNA*; R. L. SAINBURG. 

Univ. of Oregon, Pennsylvania State Univ. 

4:00 FFF5 492.20 Large trajectory deviations result from 

uncompensated Coriolis torques related to carried objects: 

A forward dynamics study. P. PIGEON*; P. DIZIO; J. R. 

LACKNER. Brandeis Univ. MS033. 

1:00 FFF6 492.21 Target-specific self-efficacy may predict 

hand selection for reaching movements in hemiparetic stroke. 

S. CHEN*; R. LEWTHWAITE; N. SCHWEIGHOFER; C. 

WINSTEIN. USC, Rancho Los Amigos Natl. Rehabil. Ctr. 

2:00 FFF7 492.22 Lack of spike synchrony between 

movement related neurons in the pontine nuclei of rhesus 

monkeys. K. TZIRIDIS; P. W. DICKE; P. THIER*. Hertie 

Institute, Dept Cognitive Neurol., Univ. of Erlangen- 

Nuremberg. 

3:00 FFF8 492.23 • Flexible motor strategies in an obstacle 

avoidance task. C. P. T. JACKSON*; J. NASHED; S. H. 

SCOTT. Queen’s Univ. 

4:00 FFF9 492.24 • Time available for planning reaching 

movements influences limb selection. S. AKPINAR*; A. 

PRZYBYLA; S. KIRAZCI; R. L. SAINBURG. Middle East 

Tech. Univ., The Penn State Univ. 

1:00 FFF10 492.25 The influence of arm biomechanics on 

decision-making. I. COS-AGUILERA*; P. CISEK. Univ. de 

Montreal. 

2:00 FFF11 492.26 • Energy minimization in arm movements. 

D. A. KISTEMAKER*; J. D. WONG; P. L. GRIBBLE. Univ. 

Western Ontario, Univ. of Western Ontario. 

3:00 FFF12 492.27 • Rapid motor responses to mechanical 

perturbations during reaching are sensitive to obstacles in the 

environment. J. NASHED*; S. H. SCOTT. Queen’s Univ. 

4:00 FFF13 492.28 Age and gender related differences to 

varying velocity and trajectory conditions in a coincidenceanticipation 

timing task. A. ROTHENBERG-CUNNINGHAM*; 

K. M. NEWELL. The Pennsylvania State Univ. 


Mon. PM

POSTER 

493. Voluntary Reaching: Motor Learning 



1:00 FFF14 493.1 Fast reinforcement learning of a motor 

task via adaptive exploration in humans. S. KIM*; D. CALLAN; 

S. SCHAAL; N. SCHWEIGHOFER. USC, ATR. 

2:00 FFF15 493.2 Stimulation of the vagus nerve paired with 

a skilled reaching task induces plasticity in rat motor cortex. N. 

KHODAPARAST*; B. A. PORTER; W. VRANA; H. SHEPARD; 

R. CHEUNG; M. FAYYAZ; C. ROHLOFF; M. P. KILGARD. 

Univ. of Texas At Dallas, Univ. of Texas at Dallas. 

3:00 FFF16 493.3 Taking advantage of a “free lunch” when 

transporting dynamic objects. C. J. HASSON*; T. SHEN; M. 

O. ABE; D. STERNAD. Northeastern Univ. 

4:00 FFF17 493.4 Dance for motor learning in children 

with cerebral palsy. C. LOPEZ-ORTIZ*; D. J. GAEBLER- 

SPIRA; L. DEON; M. SURESH; M. KASMER; M. TROYK; T. 

SHIRATORI. Rehabil. Inst. of Chicago/Northwestern Univ., 

Med. Coll Wisconsin Affil Hosps, Pathways Ctr. 

1:00 FFF18 493.5 Modulation of Fitts’s law for actual and 

imagined arm movements during the day. C. PAPAXANTHIS*; 

N. GUEUGNEAU; C. E. HAN; N. SCHWEIGOFER. Univ. de 

Bourgogne, Seoul Natl. Univ., USC. 

2:00 FFF19 493.6 Anatomical parieto-frontal connectivity 

predicts performance gains in μ rhythm-based brain-computer 

interface (BCI) training in chronic stroke. E. R. BUCH*; A. 

D. FOURKAS; C. WEBER; N. BIRBAUMER; L. G. COHEN. 

NINDS, NIH, Univ. of Oxford, Univ. of Tübingen. 

3:00 FFF20 493.7 The effects of duration and intensity of 

motor skill training on plasticity of the forelimb representation 

in the motor cortex of C57BL/6 mice. K. A. TENNANT*; D. 

L. ADKINS; M. D. SCALCO; N. A. DONLAN; A. L. ASAY; N. 

THOMAS; J. A. KLEIM; T. A. JONES. Univ. Texas Austin, Univ. 

of Florida. 

4:00 FFF21 493.8 Changes in motor cortex excitability with 

motor adaptation to novel force fields in man: Time-, direction- 

and muscle- specific relationships. S. MCMILLAN; X. TANG; 

D. L. TURNER*. Neurorehabilitation Unit. 

1:00 FFF22 493.9 What can functional imaging tell us 

about motor skill learning? L. SHMUELOF*; E. ZARAHN; P. 

MAZZONI; J. KRAKAUER. Columbia Univ. 

2:00 GGG1 493.10 Severe learning to learn impairment in 

patients with basal ganglia degeneration. J. FERNANDEZ- 

RUIZ*; R. DÍAZ; M. ALONSO; M. BOLL. Univ. Nacional 

Autonoma Mexico, INNNMVS-SSA. 

3:00 GGG2 493.11 The movement speed-accuracy relation in 

line-drawing task. T. HSIEH*; Y. LIU; G. MAYER-KRESS; K. 

NEWELL. The Pennsylvania State Univ., Natl. Taiwan Normal 

Univ. 

4:00 GGG3 493.12 Multi-source execution noise predicts 

optimal movement duration in reaching movements without 

visual feedback. Y. XIAO*; C. HAN; J. GORDON; N. 

SCHWEIGHOFER. USC, Seoul Natl. Univ. 

1:00 GGG4 493.13 Sequential effects in motor adaptation: 

The importance of far back trials. M. H. WILDER*; A. A. 

AHMED; M. C. MOZER. Univ. of Colorado at Boulder. 

2:00 GGG5 493.14 Development of prehension movement in 

infancy. M. LEE*; K. NEWELL. The Pennsylvania State Univ. 


3:00 GGG6 493.15 A mouse model of traumatic brain injury 

intended for the investigation of impairments in motor learning. 

S. C. SCHWERIN*; M. SHINDELL; L. G. COHEN; S. L. 

JULIANO. Uniformed Services Univ., NIH. 

4:00 GGG7 493.16 Control of finger and arm movements 

during fast alternate keystrokes by the professional and 

amateur pianists. T. GODA*; S. FURUYA; H. KATAYOSE; H. 

MIWA; N. NAGATA. Kwansei Gakuin Univ. 

1:00 GGG8 493.17 Robot-assisted transfer of handwriting 

skills to the non-dominant hand. A. BASTERIS; L. BRACCO; 

V. SANGUINETI*. Univ. Genoa, Italian Inst. of Technol. 

2:00 GGG9 493.18 Timing deficits following music instructions 

in persons with Down syndrome. S. D. RINGENBACH*; K. 

COFFMAN; C. CHEN; G. M. MULVEY. Arizona State Univ. 

3:00 GGG10 493.19 Optimal schedule for multi-task motor 

learning. J. LEE*; S. KIM; N. SCHWEIGHOFER. USC. 

4:00 GGG11 493.20 Modulation of proprioceptive integration 

in the motor cortex shapes human motor learning. K. 

ROSENKRANZ*; J. ROTHWELL. UCL Inst. of Neurol. 

1:00 GGG12 493.21 Disengagement and protection of motor 

memories. S. PEKNY*; S. E. CRISCIMAGNA-HEMMINGER; 

R. SHADMEHR. Johns Hopkins Univ. 

POSTER 

494. Motor Cortex and Voluntary Movement Control 



1:00 GGG13 494.1 Electrophysiological properties of 

corticospinal and corticostriatal neurons in mouse motor 

cortex. B. A. SUTER*; M. MIGLIORE; G. M. G. SHEPHERD. 

Dept Physiology, Feinberg Sch. Med., Northwestern Univ., 

Natl. Res. Council. 

2:00 GGG14 494.2 Computer network model predicts 

dependence of neocortical laminar activation patterns on form 

of stimulation. W. W. LYTTON*; G. M. G. SHEPHERD. SUNY 

Downstate, Northwestern Univ. 

3:00 GGG15 494.3 Corticocortical connections of the 

motor cortex in rats: Evidence for two motor areas. H. 

MOHAMMED*; M. K. SINGH; N. JAIN. Natl. Brain Res. Ctr. 

4:00 GGG16 494.4 Neuronal correlates of memory formation 

in motor cortex following adaptation to force field. F. I. ARCE*; 

I. NOVICK; Y. MANDELBLAT-CERF; H. BOKIL; E. VAADIA. 

Hebrew Univ., Dept Med. Neurobio. - IMRIC Hadassa Sch. of 

Med., Cold Spring Harbor Lab., Edmond and Lily Safra Ctr. for 

Brain Sci. 

1:00 GGG17 494.5 Network properties in motor cortical areas. 

J. SOHN*; A. J. C. MCMORLAND; G. W. FRASER; A. B. 

SCHWARTZ. Univ. of Pittsburgh. 

2:00 GGG18 494.6 Simultaneous 7-dimensional cortical 

control of an arm and hand robot via direct brain interface. S. 

T. CLANTON*; Z. ZOHNY; M. VELLISTE; A. B. SCHWARTZ. 

Carnegie Mellon Univ., Univ. of Pittsburgh. 

3:00 GGG19 494.7 Robust automated identification of 

neurons over multiple weeks. G. W. FRASER*; A. J. 

C. MCMORLAND; J. SOHN; A. S. WHITFORD; A. B. 

SCHWARTZ. Univ. Pittsburgh. 



4:00 GGG20 494.8 Real-time gating of cortically controlled 

prosthetic arm movement based on a separately derived 

estimate of control intention. Z. S. ZOHNY; M. VELLISTE; 

S. T. CLANTON; S. M. JEFFRIES; R. RASMUSSEN; G. L. 

HAAS*; A. B. SCHWARTZ. Univ. of Pittsburgh, Carnegie 

Mellon Univ., Univ. Pittsburgh Med. Ctr. 

1:00 GGG21 494.9 Novel methods for detection and 

estimation of functional connectivity between cortex and 

muscles. S. PEREL*; V. VENTURA; A. SCHWARTZ; M. 

SCHIEBER. Univ. of Pittsburgh, Carnegie Mellon Univ., Univ. 

of Rochester. 

2:00 GGG22 494.10 Towards better prediction of temporal 

dynamics of M1 firing rates during reaching. A. J. C. 

MCMORLAND*; Z. LIU; S. M. CHASE; M. VELLISTE; R. E. 

KASS; A. B. SCHWARTZ. Univ. Pittsburgh, Carnegie Mellon 

Univ. 

3:00 HHH1 494.11 Rapid responses in primary motor cortex 

neurons reflect an internal model of limb dynamics. J. A. 

PRUSZYNSKI*; S. H. SCOTT. Queen’s Univ. 

4:00 HHH2 494.12 • TMS evidence that primary motor 

cortex contributes to the internal model used by long-latency 

responses. I. KURTZER*; J. NASHED; J. PRUSZYNSKI; B. 

BROUWER; S. H. SCOTT. Queens Univ. 

1:00 HHH3 494.13 • Flexible modulation of perturbation 

evoked activity in primary motor cortex. M. OMRANI*; J. 

PRUSZYNSKI; S. H. SCOTT. Queen’s Univ. 

2:00 HHH4 494.14 • Neuronal correlates of voluntary 

hand movements revealed by corticokinetic coherence. M. 

BOURGUIGNON; X. DE TIÈGE; M. OP DE BEECK; P. VAN 

BOGAERT; S. GOLDMAN*; R. HARI; V. JOUSMÄKI. Unité de 

magnétoencéphalographie, ULB hôpital Erasme, Clin. Univ. 

de Bruxelles, Brain Res. Unit, Aalto Univ. Sch. of Sci. and 

Technol. 

3:00 HHH5 494.15 Encoding of multiple movement 

parameters in monkey primary motor cortex during reaching 

movements and in using a brain-machine interface. H. 

LALAZAR*; E. VAADIA. The Hebrew Univ. 

4:00 HHH6 494.16 � Fast-spiking to regular-spiking 

continuum among primate motor cortex neurons. S. C. LEVY; 

A. J. LAW; A. G. DAVIDSON*; M. H. SCHIEBER. Univ. of 

Rochester, Univ. of Rochester, Univ. Rochester. 

1:00 HHH7 494.17 Difference in modulation of 

corticomuscular coherence by changing exerted force levels 

among several upper and lower limb muscles. J. USHIYAMA*; 

J. USHIBA; A. KIMURA; M. LIU. Keio Univ. Sch. of Med., Keio 

Univ. Tsukigase Rehabil. Ctr. 

2:00 HHH8 494.18 Grasping in primary motor cortex: 

Encoding study using the generalized linear model framework. 

M. SALEH*; K. TAKAHASHI; Y. AMIT; N. G. HATSOPOULOS. 

Univ. Chicago, Univ. of Chicago. 

3:00 HHH9 494.19 Alterations in neural spiking rate and 

spiking associations in the cat motor cortex are related to 

errors in reaching. D. PUTRINO*; Z. CHEN; S. GHOSH; E. N. 

BROWN. MIT, Massachusetts Gen. Hosp., Univ. of Western 

Australia. 

4:00 HHH10 494.20 Motor cortex single neuron and population 

contributions to compensation for multiple dynamic force 

fields. T. ADDOU*; N. KROUCHEV; J. KALASKA. Univ. of 

Montreal. 

1:00 HHH11 494.21 Neural coding of corrective movements in 

motor cortex. A. DICKEY*; Y. AMIT; N. G. HATSOPOULOS. 

Univ. Chicago. 



2:00 HHH12 494.22 Modulation of sensory responses at 

spinal and cortical levels during preparation and execution 

of voluntary movement. K. SEKI*; E. E. FETZ. Natl.inst. 

Neurosci., Dept. Physiol. & Biophys., and Washington Natl. 

Primate Res. Ctr. 

3:00 HHH13 494.23 • Relation of primary motor cortical 

firing and patterns in hand shaping. J. F. KRAYENHAGEN 

PROSISE*; C. M. HENDRIX; T. J. EBNER. St. Ambrose Univ., 

Univ. of Minnesota. 

4:00 HHH14 494.24 Optimal stimulus parameters for mapping 

muscle synergies and associated movements evoked from 

M1 cortex with repetitive ICMS. G. M. VAN ACKER*, III; S. 

L. AMUNDSEN; W. MESSAMORE; H. M. HUDSON; H. Y. 

ZHANG; C. W. LUCHIES; A. L. KOVAC; P. D. CHENEY. Univ. 

Kansas Med. Cntr, Univ. of Kansas. 

1:00 HHH15 494.25 Muscle synergies represented in the 

output of hindlimb M1 in comparison to forelimb M1 of the 

rhesus macaque. H. M. HUDSON*; D. M. GRIFFIN; M. C. 

PARK; A. BELHAJ-SAÏF; P. D. CHENEY. Univ. Kansas Med. 

Ctr., Univ. of Fribourg. 

2:00 HHH16 494.26 Output effects on hindlimb muscles 

assessed with spike triggered averaging of EMG activity 

from individual cortical cells. W. G. MESSAMORE*; H. 

M. HUDSON; G. M. VAN ACKER, III; H. Y. ZHANG; A. L. 

KOVAC; P. D. CHENEY. Univ. Kansas Med. Ctr. 

3:00 HHH17 494.27 Context-related frequency modulations 

of motor cortical LFP beta oscillations. B. E. KILAVIK*; A. 

PONCE-ALVAREZ; J. CONFAIS; A. RIEHLE. INCM, CNRS - 

Univ. Aix-Marseille 2. 

4:00 HHH18 494.28 Complex movements evoked by 

optogenetic stimulation of the mouse motor cortex. T. C. 

HARRISON*; O. G. S. AYLING; T. H. MURPHY. Univ. of 


1:00 HHH19 494.29 Mathematical formulation of feedback 

control by neural populations. T. D. SANGER*. USC. 

2:00 HHH20 494.30 Last-order interneurons innervating 

forelimb motoneurons in the spinal cord of the monkey. J. 

RATHELOT*; P. L. STRICK. Univ. Pittsburgh, Veterans Affairs 

Med. Ctr. 

POSTER 

495. Sexual Behavior: Steroid Mechanisms 



1:00 HHH21 495.1 � “Nice Guys Finish Last”: Mate choice, 

reproductive success, and testosterone in Long-Evans rats. C. 

WINLAND; J. BOLTON; B. FORD; J. TINKER; S. JAMPANA; 

R. J. FROHARDT*; F. A. GUARRACI; M. ZEWAIL-FOOTE. 

Southwestern Univ., St. Edward’s Univ. 

2:00 HHH22 495.2 Androgen receptor protein in the 

copulatory system of male green anole lizards: Modulation by 

testosterone and season. H. KERVER*; J. WADE. Michigan 

State Univ. 

3:00 HHH23 495.3 Sex and seasonal differences in 

androgen-metabolizing enzymes in the green anole lizard 

brain: Co-localization with androgen receptor. R. E. COHEN*; 

J. WADE. Michigan State Univ. 

4:00 HHH24 495.4 Sexual and agonistic behaviors induce 

differential activation of aromatase and vasotocin neurons in 

the chicken brain. J. XIE*; W. J. KUENZEL; A. JURKEVICH. 

Univ. of Arkansas. 


Mon. PM

1:00 HHH25 495.5 Preoptic aromatase neurons express 

GAD67 in male and female quail. C. A. CORNIL*; S. BARDET; 

B. THIMISTER; G. F. BALL; J. BALTHAZART. Univ. Liege, 

Univ. Limoges, Johns Hopkins Univ. 

2:00 HHH26 495.6 Rapid regulation of aromatase activity and 

the role of stress. M. J. DICKENS*; T. D. CHARLIER; C. A. 

CORNIL; G. F. BALL; J. BALTHAZART. Univ. of Liege, Johns 

Hopkins Univ. 

3:00 HHH27 495.7 Steroid receptor coactivator 2 (SRC- 

2) mediates steroid-dependent male sexual behavior and 

neuroplasticity in Japanese quail (Coturnix japonica). N. 

NIESSEN*; J. BALTHAZART; G. F. BALL; T. D. CHARLIER. 

Univ. of Liege, Johns Hopkins Univ. 

4:00 HHH28 495.8 What drives female reproductive behavior 

in fish? Endocrine regulation of female sexual displays 

in a species with sex-role reversal. D. GONÇALVES*; M. 

BARUZZO; S. COSTA; M. TELES; R. OLIVEIRA. Inst. 

Superior De Psicologia Aplicada, Champalimaud Neurosci. 

Programme, Inst. Gulbenkian da Ciência. 

1:00 HHH29 495.9 Repeated estradiol sensitizes sexual 

behaviors of ovariectomized rats: Strain effects. S. JONES*; 

J. GREGGAIN-MOHR; S. FARRELL; J. G. PFAUS. Concordia 

Univ. 

2:00 HHH30 495.10 Redundant mechanisms involved in 

progesterone’s protection against restraint-induced inhibition 

of lordosis behavior. L. L. UPHOUSE*; J. E. HASSELL; C. S. 

J. MIRYALA; C. HIEGEL. Texas Woman’s Univ. 

3:00 HHH31 495.11 Estrogen-induced chromatin remodeling 

and gene transcription in the ventromedial hypothalamus. 

K. GAGNIDZE*; Z. M. WEIL; M. KHATTAK; D. W. PFAFF. 


4:00 HHH32 495.12 Ovarian steroids modulate dopamine 

receptor expression in the medial preoptic area of female rats. 

M. GRAHAM*; M. PARADA; J. G. PFAUS. Concordia Univ. 

POSTER 

496. Early Life Experience: Postnatal/Juvenile/Adolescent 

Stress 



1:00 HHH33 496.1 Infant social behavior dysfunction predicts 

adolescent depressive- and anxiety-like behaviors. M. 

RINCON*; C. RAINEKI; S. MORICEAU; R. M. SULLIVAN. 

The Emotional Brain Institute, Nathan Kline Inst., NYU Sch. of 

Med., Univ. of Oklahoma, Ctr. for Neural Science, NYU. 

2:00 HHH34 496.2 Stress during social interactions 

with mother: Window of vulnerability for dysfunctional 

neurobehavioral development. C. RAINEKI*; S. MORICEAU; 

R. M. SULLIVAN. Nathan S. Kline Inst. / NYU Sch. of Med., 

Univ. of Oklahoma. 

3:00 HHH35 496.3 • CRF2 null mutation increases sensitivity 

to isolation rearing effects on locomotor activity in mice. S. 

B. POWELL*; J. E. GRESACK; M. A. GEYER; M. STENZEL 

POORE; S. COSTE; V. B. RISBROUGH. UCSD, Oregon Hlth. 

and Sci. Univ. 


4:00 HHH36 496.4 A mouse model to understand interactions 

between biological vulnerabilities and adverse early 

experiences on infant attachment behavior. L. SALSTEIN; 

S. MORICEAU*; T. L. ROTH; E. HAMMOCK; P. LEVITT; 

F. OKUTANI; H. KABA; R. SULLIVAN. Nathan Kline Inst., 

NYU Sch. of Med., Univ. of Oklahoma, Univ. of Alabama 

at Birmingham, Univ. of Delaware, Vanderbilt Univ., 

Neurogenetic Inst. at Keck Sch. of Med. of USC, Kochi Med. 

Sch., New York Univ. 

1:00 HHH37 496.5 Amphetamine-induced dopamine release 

in the medial prefrontal cortex and nucleus accumbens of 

adult rats following adolescent social defeat. A. R. BURKE*; 

G. L. FORSTER; A. M. NOVICK; C. L. ROBERTS; M. J. 

WATT. Sanford Sch. Med, Univ. S Dakota. 

2:00 HHH38 496.6 Childhood maltreatment is associated 

with anterior insula response to social cues of fear in women 

with intimate-partner violence PTSD. G. A. FONZO*; T. M. 

FLAGAN; S. G. SULLIVAN; C. B. ALLARD; E. M. GRIMES; A. 

N. SIMMONS; M. P. PAULUS; M. B. STEIN. San Diego State 

University/University of California-San Diego Joint Doctoral 

Pro, Univ. of California-San Diego. 

3:00 HHH39 496.7 Divergent regulation of endocannabinoid 

signaling following acute and repeated stress in adolescent 

and adult rats. T. T. LEE*; M. N. HILL; C. J. HILLARD; B. B. 

GORZALKA. Univ. of British Colombia, Rockefeller Univ., 

Med. Col. of Wisconsin. 

4:00 HHH40 496.8 Early life activation of toll-like receptor 

4 reprograms neural anti-inflammatory pathways. A. 

MOUIHATE*; M. A. GALIC; S. L. ELLIS; S. J. SPENCER; S. 

TSUTSUI; Q. J. PITTMAN. Kuwait Univ., Univ. of Calgary, 

Monash Univ. 

1:00 HHH41 496.9 • Acute and long-lasting effects of early-life 

experiences: Impact of neonatal dexamethasone treatment. 

S. E. F. CLAESSENS; J. K. BELANOFF; M. S. OITZL; D. L. 

CHAMPAGNE; E. DE KLOET*. LACDR/LUMC, Leiden Univ., 

Corcept Therapeut. 

2:00 HHH42 496.10 Developmental effects of oxytocin in 

piglets by intranasal or subcutaneous administration. J. 

RAULT; C. S. CARTER; H. CHENG*; J. P. GARNER; J. N. 

MARCHANT-FORDE; B. T. RICHERT; D. C. LAY, Jr. Purdue 

Univ., Univ. Illinois at Chicago, Purde Univ., USDA-ARS. 

3:00 HHH43 496.11 Anxiety states induced by post-weaning 

social isolation are mediated by CRF receptors in the dorsal 

raphe nucleus. G. L. FORSTER*; A. C. BLEDSOE; K. M. 

OLIVER; J. L. SCHOLL. Univ. South Dakota. 

4:00 HHH44 496.12 The impact of neonatal inflammatory injury 

on stress-related circuits in adult male and female rats. N. C. 

VICTORIA*; A. Z. MURPHY. Georgia State Univ. 

1:00 HHH45 496.13 Early postnatal stress alters extracellular 

signal-regulated kinase signaling in the corticolimbic system 

underlying emotional regulation in adult rats. S. ISHIKAWA; 

Y. YANAGAWA; M. MATSUMOTO; C. JUDO; S. KIMURA; K. 

SHIMAMURA; H. TOGASHI*. Hlth. Sci. Univ. of Hokkaido. 

2:00 HHH46 496.14 Impaired fear extinction by exposure 

to early postnatal stress: Evidence of altered neuronal 

processing in the rat hippocampus and medial prefrontal 

cortex network. Y. SAITO; M. MATSUMOTO*; Y. YANAGAWA; 

C. JUDO; S. HIRAIDE; Y. KUBO; S. ISHIKAWA; H. TOGASHI. 

Hlth. sci. Uni. Hokkaido. 

3:00 HHH47 496.15 Effects of PGE2 and COX1/2 inhibitors 

on cerebellar Purkinje cell morphology are seen during, but 

not before, the second week of development in the rat. J. 

F. KNUTSON*; S. L. DEAN; M. M. MCCARTHY. Univ. of 

Maryland, Sch. of Med. 



4:00 HHH48 496.16 • Exposure to physical stress in early 

life alters rats’ sensitivity to adult depression-like responses 

in a sex specific manner. M. WILKIN*; P. WATERS; C. 

MCCORMICK; J. MENARD. Queens Univ., Brock Univ. 

1:00 III1 496.17 Effects of novelty exposure on plasticity 

of acoustic startle response --- Modulation by maternal stress 

physiology. H. JIANG*; Z. YANG; A. A. CHEN; Y. ZHANG; 

R. D. ROMEO; B. S. MCEWEN; A. C. TANG. Univ. of New 

Mexico, Barnard Col., Rockefeller Univ. 

2:00 III2 496.18 Stress reduces cell proliferation in the 

amygdala of adolescent rats: Implications for mood and 

anxiety disorders. M. SAUL*; K. BECOATS; D. HELMREICH; 

J. L. FUDGE. Univ. of Rochester. 

3:00 III3 496.19 Hemispheric differences in serotonin 

transporter (5HTT) and receptor (5HT1A) binding potential 

in cortico-limbic regions of juvenile female rhesus monkeys: 

Effects of social rank and 5HTT genotype. M. EMBREE*; V. 

MICHOPOULOS; J. VOTAW; M. E. WILSON*; M. SANCHEZ. 

Yerkes Natl. Primate Res. Ctr., Emory Univ., Emory Univ. Sch. 

of Med. 

4:00 III4 496.20 Social subordination stress and serotonin 

transporter (5HTT) genotype affect brain white matter tract 

integrity in juvenile female macaques: A DTI study. B. R. 

HOWELL*; V. MICHOPOULOS; X. ZHANG; X. HU; M. 

WILSON; M. SANCHEZ. Emory Univ. 

1:00 III5 496.21 Protracted effects of juvenile stress, in 

mice. S. JACOBSON-PICK*; H. ANISMAN. Carleton Univ. 

2:00 III6 496.22 Assessment of the effects of stress 

during adolescence on the rewarding and aversive effects of 

morphine in adulthood. A. VERENDEEV; J. A. RINKER; A. L. 

RILEY*. American Univ. 

POSTER 

497. Early Life Experience: Prenatal factors 



1:00 III7 497.1 Prenatal programming of anxious 

behaviour, corticotropin releasing hormone (CRH) mRNA and 

CRH receptor mRNA expression in the amygdala in rats. P. 

J. BRUNTON*; M. V. DONADIO; J. A. RUSSELL. Univ. of 

Edinburgh, Catholic Univ. of Rio Grande do Sul. 

2:00 III8 497.2 Gestational stress: A morphological and 

endocrine overview in male rat progeny. M. E. PALLARÉS; E. 

ADROVER; M. R. KATUNAR; C. J. BAIER; R. S. CALANDRA; 

S. I. GONZÁLEZ CALVAR; M. C. ANTONELLI*. IQUIFIB, Lab. 

de Esteroides-IBYME. 

3:00 III9 497.3 Effects of prenatal glucocorticoid treatment 

on the developing serotonin system and stress-related 

behaviors in adulthood. R. HIROI*; D. L. CARBONE; D. G. 

ZULOAGA; R. J. HANDA. Univ. of Arizona Col. of Med. - 

PHOENIX. 

4:00 III10 497.4 Glucocorticoids induce long-lasting 

effects in neural stem cells resulting in senescence-related 

alterations and increased susceptibility to oxidative stress. 

S. CECCATELLI*; R. BOSE; M. MOORS; A. CASCANTE; 

O. HERMANSON; R. TOFIGHI. Dept. of Neuroscience, 

Karolinska Institutet. 



1:00 III11 497.5 Sex-dependent morphological changes in 

the medial prefrontal cortex and hippocampus after prenatal 

stress in rats. T. SUENAGA*; M. YUKIE; D. NAKAHARA. 

Hamamatsu Univ. Sch. of Med., Intl. Univ. of Hlth. and 

Welfare. 

2:00 III12 497.6 Effects of prenatal stress on familiar odor 

preference in male and female rat pups. A. B. LUCION*; M. A. 

SOUZA; L. A. CENTENARO; R. E. SZAWKA; M. B. ALVES. 

Univ. Federal Do Rio Grande Sul UFRGS, Federal Univ. of 

Rio Grande do Sul, Univ. of Sao Paulo. 

3:00 III13 497.7 Effects of exposure to titanium dioxide 

on activation of corticotrophin-releasing hormone neurons 

in pregnant rats and its offspring. S. YANAGITA*; J. 

KANEMARU; M. UMEZAWA; S. YOKOTA; K. TAKEDA. Tokyo 

Univ. of Sci. 

4:00 III14 497.8 Characterization of striatal monoamine 

systems and related-behavior in a prenatal restraint 

stress rat model. S. MACCARI*, Prof; J. MARROCCO; M. 

DARNAUDERY; T. CASSANO; S. GAETANI; G. VAN CAMP; 

J. MAIRESSE; H. BOUWALERH; S. MORLEY-FLETCHER. 

North Lille Univ. of France/ Umr8576 CNRS, PsyNuGen UMR 

INRA 1286 CNRS 5226 Univ. Bordeaux 2, Dept Biomed. 

Sciences, Med. Sch. Univ. of Foggia, Neuropharmacology, 

Sapienza Univ. 

1:00 III15 497.9 • Prenatal stress and diet increases 

offspring susceptibility to diet-induced obesity and affects 

hypothalamic gene expression and DNA methylation. K. L. 

TAMASHIRO*; R. S. LEE; R. H. PURCELL; J. I. KOENIG; 

J. B. POTASH; T. H. MORAN. Johns Hopkins Univ., Univ. of 

Maryland. 

2:00 III16 497.10 Transgenerational epigenetic 

programming of male offspring stress responsivity. C. P. 

MORGAN*; T. L. BALE. Univ. of Pennsylvania. 

3:00 III17 497.11 Prenatal hormone exposure effects on 

cortisol response over the lifespan in Suffolk sheep. E. M. 

PECKHAM*; E. K. ROBERTS; M. M. MAHONEY; T. M. LEE. 

Univ. Michigan, Univ. of Illinois. 

4:00 III18 497.12 Vulnerability to addiction can be 

modulated by dopamine. A. RODRIGUES; P. LEÃO; M. 

OLIVEIRA; J. PÊGO; A. FRANKY; P. MORGADO; A. 

MESQUITA; D. ARAUJO; O. F. ALMEIDA*; N. SOUSA. Life 

and Hlth. Sci. Res. Inst. (ICVS), Univ. of Minho, Max Planck 

Inst. Psychiatry. 

1:00 III19 497.13 Inappropriate prenatal exposure to 

glucocorticoids profoundly alters neuronal and astrocyte 

populations within the dopaminergic pathways of the midbrain. 

S. MCARTHUR*; S. MAZHAR SIDDIQI; G. E. GILLIES. 

Imperial Col. London. 

2:00 III20 497.14 Effect of prenatal glucocorticoid treatment 

on adrenal phenylethanolamine N-methyltransferase gene 

expression in the adult Wistar-Kyoto rat. P. NGUYEN; H. 

PELTSCH; J. GRANDBOIS; J. CRISPO; G. UBRIACO; D. 

ANSELL; J. EIBL; T. TAI*. Laurentian Univ., Northern Ontario 

Sch. Med. 

3:00 III21 497.15 Tracking hippocampal neuroplasticityrelated 

regulation of emotionality by a proteomic approach 

in a rat model of prenatal restraint stress. S. MORLEY- 

FLETCHER*; A. VERCOUTTER-EDOUART; J. MARROCCO; 

A. ZUENA; A. GIOVINE; J. MICHALSKI; S. MACCARI. 

Neuroplasticity Team UMRCNRS 8576 Univ. of Lille 1, 

Cell Signalling Team UMR CNRS 8576 Univ. of Lille 1, 

Neuropharmacology, Sapienza Univ. 


Mon. PM

4:00 III22 497.16 IUGR alters hippocampal brahma-related 

gene-1 expression and its occupancy on glucocorticoid 

receptor gene promoters. X. KE*; R. MCKNIGHT; C. 

CALLAWAY; X. YU; R. LANE. Univ. Utah Schl Med. 

1:00 III23 497.17 • Hypothalamic and amygdalar gene 

expression changes in the adult brain following stress and/ 

or antidepressant exposure in utero. C. H. BOURKE*; C. 

F. CAPELLO; S. M. ROGERS; D. E. OLSON; K. BOSS- 

WILLIAMS; M. J. OWENS. Emory Univ., Atlanta VAMC, 

Emory Univ. Sch. of Med. 

POSTER 

498. food Intake and Energy Balance: Neuropeptides II 



1:00 III24 498.1 The role of the NOP receptor in 

regulating food intake, meal pattern, and the excitability of 

proopiomelanocortin neurons. E. J. WAGNER*; B. FARHANG; 

L. PIETRUSZEWSKI; K. LUTFY. Western Univ. of Hlth. Sci. 

2:00 III25 498.2 Intact actuate nucleus is required for food 

intake inhibition effect of electroacupuncture on obese rats. 

F. WANG*; D. TIAN; P. TSO; J. HAN. Metabolic Dis. Institute, 

Reading Campus, Univ. of Cincinnati, Dept. of Anatomy, 

Tianjin Med. Univ., Departments of Pathology and Lab. Med. 

and Psychiatry, Univ. of Cincinnati,, Neurosci. Res. Institute, 

Peking University,. 

3:00 III26 498.3 Individual contributions of AGRP and NPY 

to leptin-dependent regulation of energy homeostasis. N. 

LUO*; S. CHUA, Jr. Albert Einstein Col. of Med. 

4:00 III27 498.4 Heterogeneity in type 2 vesicular 

glutamate transporter (VGLUT2) expression in proopiomelanocortin 

cells of the rat arcuate nucleus. G. 

WITTMANN*; R. M. LECHAN. Tufts Med. Ctr., Inst. of Exptl. 

Med., Tufts Univ. Sch. of Med. 

1:00 III28 498.5 Neuropaptide Y, agouti related protein, 

proopiomelanocortin mRNA expression in the arcuate nucleus 

of the hypothalamus and plasma leptin in response to food 

intake are modulated by glucocorticoids. E. T. UCHOA*; L. 

E. C. M. SILVA; J. ANTUNES-RODRIGUES; L. L. K. ELIAS. 

Univ. Sao Paulo (USP). 

2:00 III29 498.6 Leptin-saporin lesion of hypothalamic 

arcuate neurons impairs circadian feeding rhythms. A. LI*; T. 

T. DINH; Q. WANG; M. F. WIATER; S. RITTER. Washington 

State Univ. 

3:00 III30 498.7 Polymorphisms in the AgRP gene are 

associated with an increased risk for the development of 

activity-based anorexia in the female rat. L. NIKONOVA; J. C. 

SANTOLLO; L. A. ECKEL*. Florida State Univ. 

4:00 III31 498.8 Global 30% reduced maternal nutrition 

(RMN) from 0.16 to 0.9 of gestation (G) is accompanied by 

decreases in Cocaine-and Amphetamine-Regulated Transcript 

(CART) protein expression in the fetal baboon hypothalamic 

arcuate (ARC) and paraventricular (PVN) Nuclei. C. LI*; P. W. 

NATHANIELSZ; T. MCDONALD. Univ. Texas Hlth. Sci. Ctr, 

San Antonio. 

1:00 III32 498.9 GnIH inhibits hypothalamic arcuate 

nucleus POMC cells. L. FU; A. N. VAN DEN POL*. Yale Univ., 



2:00 III33 498.10 Auto-inhibition of POMC neurons by betaendorphin 

through mu -opioid receptor in arcuate neurons 

of hypothalamus. M. GHAMARI-LANGROUDI*; R. CONE. 

Vanderbilt Univ. 

3:00 III34 498.11 Glucose stimulation of hypothalamic MCH 

neurons involves KATP channels, is modulated by UCP2, 

and regulates peripheral glucose homeostasis. D. KONG*; L. 

VONG; L. E. PARTON; C. YE; Q. TONG; X. HU; B. CHOI; J. 

C. BRÜNING; B. B. LOWELL. Beth Israel Deaconess Med. 

Ctr. and Harvard Med. Sch., Univ. of Cologne. 

4:00 III35 498.12 � Gastrin-releasing peptide causes 

primary anorexigenic effect in chickens. C. DOUGHERTY*; M. 

A. CLINE. Radford Univ. 

1:00 III36 498.13 Effect of mixed medicinal herbal extract 

on anti-obesity via neuroendocrine control in obese rats 

induced by a high fat diet. S. HWANG; I. SHIN; J. S. HWANG; 

M. KIM*. Daegu Haany Univ., R&D Team for the New Drug 

of Oriental Med. (BK21),Daegu Haany Univ., Kwanmoon 

Oriental Med. Clin. 

2:00 III37 498.14 Brain stimulation of somatostatin 2 

receptors stimulates feeding in mice: analysis of food intake 

pattern. A. STENGEL; M. GOEBEL; L. WANG; J. RIVIER; Y. 

TACHE*. UCLA Dep Med. Div. Digestive Dis, Peptide Biol. 

Laboratories, Salk Inst. 

3:00 III38 498.15 � A role for galanin-like peptide (GALP) 

in the regulation of reproduction and energy homeostasis in 

female rats. E. A. LEATHLEY*; G. S. FRALEY. Hope Col. 

4:00 III39 498.16 Differential regulation of hypothalamic 

neuropeptide Y and agouti-related protein expression during 

psychological stress and insulin-induced hypoglycemia. K. 

J. KOVÁCS*; O. DRODOVSZKY; E. ZELEI; B. PINTÉR; S. 

FERENCZI. Inst. of Exptl. Med. 

1:00 III40 498.17 Decreased plasma levels of brain-derived 

neurotrophic factor and its relationship with obesity-related 

metabolic complication, birth weight and plasma levels of 

adipocytokines in obese children. Y. YAMAMOTO*; S. ARAKI; 

K. DOBASHI; M. GOTOH; K. KUSUHARA. Univ. Occupat & 

Environ Hlth., Dept. of Pediatrics, Sch. of Medicine, Showa 

Univ. 

2:00 III41 498.18 � The orexigenic effect of centrally 

administered kyotorphin is associated with mu, kappa, and 

delta subtypes of opioid receptors. B. A. NEWMYER*; A. 

LONKAR; B. BRUMFIELD; M. A. CLINE. Radford Univ. 

3:00 III42 498.19 • VGF deficiency decreases adrenal 

chromogranin B levels and chromaffin granule size. S. 

FARGALI*; A. GARCIA; A. ELSTE; W. G. JANSSEN; 

M. SADAHIRO; G. W. HUNTLEY; D. L. BENSON; S. R. 

SALTON. Mount Sinai Sch. of Med. 

4:00 III43 498.20 Running wheel activity attenuates central 

mu-opioid receptor induced hyperphagia in rats. N. LIANG*; 

N. T. BELLO; T. H. MORAN. Johns Hopkins Univ. Sch. of 

Med. 

1:00 III44 498.21 • Functional evaluations of MC4R allelic 

variants using STEP luciferase assays. C. S. HO*; C. LI; M. 

KREUZ; A. W. AVERY; M. I. MORANO. Originus Inc. 

2:00 III45 498.22 Lack of the galanin type 1 receptor only 

subtly reduces food intake and body weight gain in mice 

chronically fed a high-fat diet. E. M. FEKETE*; J. B. FRIHAUF; 

S. L. PARYLAK; Y. Y. KIM; F. C. XIA; X. LU; E. P. ZORRILLA. 

The Scripps Res. Inst., Pecs Univ. Med. Sch., Univ. of 

California San Diego. 



3:00 III46 498.23 Chronic unpredictable stress 

altered energy homeostasis and anxiogenic behavior in 

prepronociceptin (ppOFQ/N) deficient mice. E. MALLIMO*; A. 

KUSNECOV. Rutgers Univ. 

4:00 III47 498.24 Manserin, a novel secretogranin ii-derived 

peptide, distributes in the rat endocrine pancreas. K. TANO; A. 

OYABU; Y. TASHIRO; N. KAMADA; N. NARITA; F. NASU; M. 

NARITA*. Mie Univ., Suzuka Univ. of Med. Sci., Mie University, 

Sch. of Med., Bunkyo Univ. 

1:00 III48 498.25 Serum levels of nesfatin-1 in patients with 

sleep apnea syndrome. T. KANBAYASHI*; K. HOSOKAWA; 

T. KIZAWA; J. TOKUNAGA; T. NISHIJIMA; W. ITO; M. SATO; 

Y. TAKAMATSU; S. SAKURAI; A. SUWABE; T. SHIMIZU. 

Akita Univ. Sch. Med., Iwate Med. Univ. Sch. of Med., Lab. of 

Systems Biol. and Med. 

POSTER 

499. Circadian Physiology 



1:00 III49 499.1 Effect of photoperiod of long or short days 

uppon locomotor anctivity and anxiety in Mongolia gerbils 

Meriones unguiculatus. C. R. JUAREZ-TAPIA*; M. MIRANDA- 

ANAYA; A. CARMONA-CASTRO; P. DURAN. Natl. Univ. of 

Mexico (UNAM). 

2:00 III50 499.2 Regulation of feeding activity rhythm 

by food-entrainable oscillator in the Japanese catfish, 

Plototus japonicus. M. KASAI*; T. HIROCHI; S. KIYOHARA. 

Kagoshima Univ. 

3:00 JJJ1 499.3 Mathematical model of suprachiasmatic 

nucleus to describe the asymmetric resynchronization after 

an abrupt shift of the light: dark cycle. T. ASAKAWA*; K. 

MASUMOTO; S. KOINUMA; M. NAGANO; Y. SHIGEYOSHI. 

Sony Corp., Kindai Univ. 

4:00 JJJ2 499.4 Reorganization of the mammalian 

pacemaker under ultra long day lengths. J. A. EVANS*; T. 

L. LEISE; O. CASTANON-CERVANTES; A. J. DAVIDSON. 

Morehouse Sch. of Med., Amherst Col. 

1:00 JJJ3 499.5 Repeated jet lag inhibits adult 

neurogenesis and produces long-term cognitive deficits in 

female hamsters. E. M. GIBSON*; C. WANG; S. TJHO; N. 

KHATTAR; L. J. KRIEGSFELD. UC Berkeley. 

2:00 JJJ4 499.6 Period1 rhythms in the suprachiasmatic 

nucleus are delayed during puberty in the degu (Octodon 

degus). M. H. HAGENAUER*; S. S. WANG; D. B. 

ALTSHULER; T. M. LEE. Univ. of Michigan. 

3:00 JJJ5 499.7 Daily scheduled voluntary exercise 

partially restores SCN function in mice lacking VIP-VPAC 2 

signaling. A. T. L. HUGHES; C. GUILDING; H. PIGGINS*. 

Univ. Manchester. 

4:00 JJJ6 499.8 Serotonergic enhancement of photic 

phase shifts involves altered time courses for some 

immediate-early genes. V. M. SMITH*; R. T. JEFFERS; M. 

C. ANTLE. Dept. of Psychology - Univ. of Calgary, Hotchkiss 

Brain Inst., Physiol. and Pharmacol. 

1:00 JJJ7 499.9 Observations of separable food-entrained 

and drug-entrained oscillators in the rat. H. T. JANSEN*; G. N. 

STARK; A. SERGEEVA; B. A. SORG. Washington State Univ. 



2:00 JJJ8 499.10 Diurnal, age and immune regulation of 

Interleukin-1β and Interleukin-1 type 1 receptor in the mouse 

suprachiasmatic nucleus. A. L. BEYNON*; J. S. DAVIES; A. N. 

COOGAN. Swansea Univ., Natl. Univ. of Ireland, Maynooth. 

3:00 JJJ9 499.11 Rhythms of neural activity in serotonergic 

cells with access to the cerebrospinal fluid in a diurnal brain. 

A. CASTILLO-RUIZ*; A. A. NUNEZ; L. SMALE. Michigan 

State Univ. 

4:00 JJJ10 499.12 The role of ghrelin in food anticipatory 

activity. M. MERKESTEIN*; M. A. D. BRANS; M. C. M. 

LUIJENDIJK; M. A. VAN GESTEL; A. J. VAN ROZEN; R. A. H. 

ADAN. Rudolf Magnus Inst. of Neurosci. 

1:00 JJJ11 499.13 Effects of photoperiod-driven variations 

in life-history on longevity and aging in the Siberian hamster, 

Phodopus sungorus. E. E. RAIEWSKI*; M. R. GORMAN. 

Univ. California San Diego. 

2:00 JJJ12 499.14 Evidence for circadian rhythm and the role 

of serotonin in antipredator behavior in a nocturnal spider. T. 

C. JONES; T. S. AKOURY; C. K. HAUSER; D. J. MOORE*. 

East Tennessee St Univ. 

3:00 JJJ13 499.15 Photic-like resetting of the mammalian 

circadian clock in vitro by a copper chelator. R. A. PROSSER*; 

Y. YAMADA; C. PETERSON. Univ. Tennessee. 

4:00 JJJ14 499.16 Locomotion circadian rhythm affected 

by genetic differences among high- and low- yawning 

Sprague-Dawley rats. A. D. ESCOBAR*; M. C. CORTES; 

J. R. EGUIBAR; R. AGUILAR. Inst. De Fisiología BUAP, 

Benemérita Univ. Autónoma de Puebla, Univ. Nacional 

Autónoma de México. 

1:00 JJJ15 499.17 • Validation of a circadian activity model in 

socially housed cynomolgus macaques. G. J. DEMARCO*; T. 

A. SWANSON. Pfizer Inc. 

2:00 JJJ16 499.18 Continuous alcohol exposure impairs 

circadian adaptation to simulated time zone travel in 

C57BL/6J mice. M. SINNING*; M. R. GORMAN. UCSD, 

UCSD Dept. of Psychology and Ctr. for Chronobiology. 

3:00 JJJ17 499.19 Circadian rhythms in olfactory 

discrimination persist after scn lesions. D. GRANADOS- 

FUENTES*; G. BEN-JOSEF; G. PERRY; A. SULLIVAN- 

WILSON; D. A. WILSON; E. D. HERZOG. Washington Univ., 

Grinnell Col., New York Univ. Sch. of Med. 

4:00 JJJ18 499.20 Methamphetamine-entrainable circadian 

rhythms persist following repeated injections. D. A. WOOD*; 

P. FULLER; C. SAPER. Harvard Med. School/Beth Israel 

Deaconess Med. Ctr., Harvard Med. School/Beth Israel 

Deaconess Med. Center,. 

1:00 JJJ19 499.21 The interrelation of the circadian clock 

and serotonin gene networks. H. E. SIKES RESUEHR*; J. C. 

AXLEY; G. ALLEN; E. DENERIS; D. MCMAHON. Vanderbilt 

Univ., Texas A&M Univ., Case Western Reserve Univ. 

2:00 JJJ20 499.22 Ghrelin modulates circadian 

thermoregulation via hypothalamic mechanisms. K. 

TOKIZAWA*; Y. ONOUE; Y. UCHIDA; H. MORI; M. 

NAKAMURA; K. NAGASHIMA. Waseda Univ. 

3:00 JJJ21 499.23 Daily performance of a sustained attention 

task during light phase desynchronizes circadian oscillators in 

nocturnal rats. J. YAN*; G. PAOLONE; J. BOSTWICK; W. A. 

HOOGERWERF; M. SARTER; T. M. LEE. Univ. of Michigan, 

Ann Arbor. 

4:00 JJJ22 499.24 Genetic ablation of the SCN abolishes 

the circadian rhythms of temperature and locomotor activity 

in mice. R. VETRIVELAN*; P. M. FULLER; C. B. SAPER. 



Mon. PM

1:00 JJJ23 499.25 Meal duration, amount of food and 

motivation, modulate food anticipatory activity and Period1 

protein expression in the dorsomedial hypothalamic nucleus. 

M. VERWEY*; S. AMIR. Concordia Univ. 

2:00 JJJ24 499.26 Food anticipatory behavior in growth 

hormone secretagogue receptor knock-out mice. E. 

WADDINGTON LAMONT*; J. S. BRUTON; A. ABIZAID. Inst. 

of Neuroscience, Carleton Univ. 

3:00 JJJ25 499.27 The effect of photoperiodic history on jet 

lag. E. M. HARRISON*; M. R. GORMAN. UCSD. 

4:00 JJJ26 499.28 Temporal reversal of brain extra-SCN 

oscillators does not prevent the nocturnal rise in melatonin. 

C. A. MARTIN-FAIREY*; C. RAMANATHAN; L. SMALE; A. 

NUNEZ. Michigan State University. 

1:00 JJJ27 499.29 A pineal-specific agouti protein regulates 

teleost background adaptation. C. ZHANG; Y. SONG; A. M. 

VANHOOSE*; D. A. THOMPSON; M. A. MADONNA; G. L. 

MILHAUSER; S. TORO; Z. VARGA; M. WESTERFIELD; J. 

GAMSE; W. CHEN; R. D. CONE. Vanderbilt Univ., Salk Inst. 

for Biol. Sci., Vanderbilt Univ. Med. Sch., UCSC, Univ. of 

Oregon. 

2:00 JJJ28 499.30 Evidence for PER2 mediation of postnatal 

alcohol induced alteration of metabolic sensing in the 

hypothalamus of mice. M. A. AGAPITO*; J. C. BARREIRA; D. 

K. SARKAR. Rutgers University/Umdnj. 

3:00 JJJ29 499.31 MT 1 melatonin receptor mediates the 

entrainment of forced desynchronized circadian activity 

rhythms in the C3H/HeN mice. M. L. DUBOCOVICH*; O. 

RAWASHDEH; I. STEPIEN; R. L. HUDSON. Univ. at Buffalo 

Sch. of Med. and Biomed. Sci. 

POSTER 

500. Sleep Neurochemistry and Molecular Biology I 



1:00 JJJ30 500.1 Dynamic changes in neurotransmitter 

levels in the basal forebrain during and after sleep deprivation. 

J. C. ZANT*; C. H. C. LEENAARS; A. KOSTIN; E. J. VAN 

SOMEREN; T. PORKKA-HEISKANEN. Inst. Biomed, 

Netherlands Inst. for Neurosci. 

2:00 JJJ31 500.2 Time course of changes in adenosine, 

nitric oxide (NO) and inducible NO synthase (iNOS) during 

prolonged sleep deprivation in the basal forebrain and 

cortex. A. V. KALINCHUK*; R. W. MCCARLEY; T. PORKKA- 

HEISKANEN; R. BASHEER. Harvard Med. School-VA Boston 

Healthcare Syst., Inst. of Biomedicine, Univ. of Helsinki. 

3:00 JJJ32 500.3 • The effect of sleep and wakefulness on 

adenosine release in the basal forebrain in vitro. R. E. SIMS*; 

N. DALE. Univ. of Warwick. 

4:00 JJJ33 500.4 Estradiol facilitates REM sleep recovery 

following sleep deprivation in a phase-dependent manner. M. 

D. SCHWARTZ*; J. A. MONG. Univ. of Maryland Sch. of Med. 

1:00 JJJ34 500.5 Administration of 3,3’-5-triiodothyronine 

by microinjection to the median preoptic nucleus or 

intraperitoneal injection alters EEG-defined sleep in euthyroid 

rats. P. F. GIANNOPOULOS; S. MOFFETT; T. D. JAMES; J. 

V. MARTIN*. Rutgers, The State Univ. of New Jersey, Rutgers 

Univ. 

2:00 JJJ35 500.6 Sleep regulation in PPARα knockout mice. 

N. SHIMIZU*; S. CHIKAHISA; K. KITAOKA; H. SEI. Inst. of 

Hlth. Biosciences, The Univ. of Tokushima Grad. Sch. 


3:00 JJJ36 500.7 Duration of sleep episodes in rat varies as 

a function of amino acid concentration in the pontine reticular 

nucleus, oral part (PnO). C. J. WATSON*; R. LYDIC; H. A. 

BAGHDOYAN. Univ. Michigan. 

4:00 JJJ37 500.8 Hypothalamic AMPK contributes to 

homeostatic sleep regulation. S. CHIKAHISA*; K. KITAOKA; 

N. SHIMIZU; H. SEI. Inst. of Hlth. Biosciences, The Univ. of 

Tokushima Grad. Sch. 

1:00 JJJ38 500.9 GABA A receptor subunits located in 

cholinergic terminals in the pontine reticular formation 

implicated in REM sleep control. C. LIANG; G. A. MARKS*. 

Veterans Affairs Med. Ctr., Univ. Texas Southwestern Med. 

Ctr. & Dallas VA. 

2:00 JJJ39 500.10 • Activation of pedunculopontine tegmental 

protein kinase A (PKA): A mechanism for homeostatic 

regulation of rapid eye movement (REM) sleep. S. DATTA*; F. 

DESARNAUD. Boston Univ. Sch. Med. 

3:00 JJJ40 500.11 Almorexant promotes sleep in mice by 

blocking OX1 and OX2 orexin receptors. T. MOCHIZUKI*; 

E. L. CLARK; M. YAMAMOTO; C. ALEXANDRE; T. E. 

SCAMMELL. Beth Israel Deaconess Med. Ctr. 

4:00 JJJ41 500.12 Retinoic acid receptors antagonist LE540 

attenuates EEG delta power during sleep via dopamine D1 

receptor in mice. K. KITAOKA*; M. SHIMIZU; N. SHIMIZU; 

S. CHIKAHISA; K. YOSHIZAKI; H. SEI. Inst. of Hlth. 

Biosciences, The Univ. of Tokushima Grad. Sch. 

1:00 JJJ42 500.13 The role of type 1 equilibrative nucleoside 

transporter (ENT1) in sleep-wake regulation: A lesson from 

ENT1 knockout mice. T. KIM*; R. W. MCCARLEY; R. VIJAY; 

A. KALINCHUK; M. DWORAK; D. CHOI; R. O. MESSING; 

R. BASHEER. Psychiatry Research, VA Boston Healthcasre 

System-Harvard Med. Sch., Univ. of Louisville, Mayo Clin., 

Univ. of California. 

2:00 JJJ43 500.14 � Postnatal stress: Effects on sleep and 

the role of the endocannabinoid system in the adult rat. N. 

M. REYES PRIETO*; M. M. PÉREZ- MORALES; O. PECH 

RUEDA; M. MÉNDEZ DIAZ; O. PROSPÉRO- GARCÍA. Univ. 

Nacional Autonoma De México. 

3:00 JJJ44 500.15 Astrocyte-derived adenosine modulates 

increased sleep pressure during inflammatory response. A. 

NADJAR; S. LAYE; T. BLUTSTEIN*; P. G. HAYDON. INRA 

1286 - CNRS 5226 - Univ. of Bordeaux2, Tufts Univ. Sch. of 

Med. 

4:00 JJJ45 500.16 Effects of the administration of 2-AG into 

the lateral hypothalamus on the sleep wake cycle of rats. M. 

PÉREZ-MORALES*; N. REYES PRIETO; I. ALVARADO; R. 

PEDROZA-LLINÁS; Ó. PROSPÉRO-GARCÍA. Facultad De 

Medicina UNAM. 

1:00 JJJ46 500.17 Fatty acid synthase inhibitor, C75, 

suppresses sleep and body temperature in mice. E. 

SZENTIRMAI*; L. KAPAS. Washington State Univ. 

2:00 JJJ47 500.18 Effects on sleep after intrahypothalamic 

administration of the fatty acid amide hydrolase inhibitor 

URB597. E. MURILLO-RODRIGUEZ*; D. MILLÁN-ALDACO; 

M. PALOMERO-RIVERO; R. DRUCKER-COLÍN. Div. 

Ciencias de la Salud., Univ. Anahuac Mayab., Inst. de 

Fisiología Celular. Univ. Nacional Autónoma de México. 

3:00 JJJ48 500.19 Aging and cortical sleep homeostasis: 

BDNF and Homer1 expression. K. RYTKONEN*; T. PORKKA- 

HEISKANEN. Inst. Biomed. 

4:00 JJJ49 500.20 Sleep degrades ubiquitinated proteins. 

R. P. KONADHODE; D. PELLURU; P. J. SHIROMANI*. VA - 




1:00 JJJ50 500.21 Sleep-wake chromosome 1 QTL 

exploration in the mouse. J. R. OWENS*; K. SHIMOMURA; P. 

KOTHARI; C. J. OLKER; J. MILLSTEIN; M. VITATERNA; C. J. 

WINROW; A. KASARSKIS; J. J. RENGER; J. S. TAKAHASHI; 

F. W. TUREK. Northwestern Univ., Sage Bionetworks, Merck 

Res. Labs., HHMI, UT Southwestern Med. Ctr. 

2:00 KKK1 500.22 Effects of glutamatergic and cholinergic 

agonists on gamma band activity in the parafascicular 

nucleus. N. KEZUNOVIC*; C. SIMON; J. HYDE; P. BECK; E. 

GARCIA-RILL. UAMS. 


agonists on gamma band activity in the subcoeruleus nucleus. 

J. R. HYDE*; N. KEZUNOVIC; C. SIMON; K. SMITH; B. 

LUSTER; E. GARCIA-RILL. Univ. of Arkansas For Med. Sci. 


agonists on gamma band activity in the pedunculopontine 

nucleus. C. SIMON*; N. KEZUNOVIC; J. HYDE; C. 

BRAUNFISCH; E. GARCIA-RILL. Univ. of Arkansas For Med. 

Sci. 

1:00 KKK4 500.25 Potentiation of cholinergic receptor 

activation in the pedunculopontine nucleus by modafinil. K. 

SMITH*; N. KEZUNOVIC; J. HYDE; E. GARCIA-RILL. UAMS. 

2:00 KKK5 500.26 ER stress sensitivities of orexin neurons 

in rat hypothalamic slice culture. S. MICHINAGA*; A. 

HISATSUNE; Y. ISOHAMA; H. KATSUKI. Kumamoto Univ. 

POSTER 

501. Neural Attentional Network 



1:00 KKK6 501.1 Largely overlapping networks mediating 

attentional control during spatial and object-based 

attention. C. M. STOPPEL*; H. STRUMPF; J. HOPF; M. A. 

SCHOENFELD. Otto-von-Guericke Univ., Leibniz-Institute for 

Neurobio., Kliniken Schmieder. 

2:00 KKK7 501.2 Whole-brain rs-fcMRI networks restructure 

over development, strengthening long-distance relationships 

and decreasing degree assortativity. J. D. POWER*; A. L. 

COHEN; S. M. NELSON; G. S. WIG; K. A. BARNES; J. A. 

CHURCH; F. M. MIEZIN; A. C. VOGEL; B. L. SCHLAGGAR; 

S. E. PETERSEN. Washington Univ. 

3:00 KKK8 501.3 Attentional topographic maps revealed in 

cortical population vectors during randomized covert shifts of 

visual attention. C. KALBERLAH*; Y. CHEN; J. HAYNES. MPI 

CBS, Bernstein Ctr. for Computat. Neurosci. 

4:00 KKK9 501.4 Resting state fMRI connectivity predicts 

behavioral performance in a spatial selective attention task. 

X. WEN*; M. DING. Dept. of Biomed. Engineering, Univ. of 

Florida. 

1:00 KKK10 501.5 Neural correlates of cognitive control at 

the item specific level in the Stroop task. J. GRANDJEAN*; 

K. D’OSTILIO; E. SALMON; A. LUXEN; P. MAQUET; F. 

COLLETTE. Univ. of Liège. 

2:00 KKK11 501.6 Higher-order relays in the thalamus: 

Integration of action and object processing. P. ROTSHTEIN*; 

G. W. HUMPHREYS; S. KUMAR; E. YOON. Univ. of 

Birmingham. 

3:00 KKK12 501.7 Subcortical mechanisms of cognitive 

control in task switching. S. CHO*; P. A. LAURENT; S. 

YANTIS. Johns Hopkins Univ. 



4:00 KKK13 501.8 Separable planning and execution stages 

for spatial shifts of attention. J. J. GREEN*; K. C. ROBERTS; 

M. G. WOLDORFF. Duke Univ. 

1:00 KKK14 501.9 Dissociating ventral and dorsal posterior 

cingulate cortex within the default mode network. D. J. 

SHARP*; S. KAMOURIEH; C. F. BECKMANN; R. LEECH. 

Imperial Col. London. 

2:00 KKK15 501.10 The neural correlates of attentional 

orienting in response to social and nonsocial cues in typical 

development. D. J. GREENE*; N. COLICH; E. ZAIDEL; M. 

IACOBONI; M. DAPRETTO. UCLA. 

3:00 KKK16 501.11 Functional neuroanatomical separation of 

rule preparation and task implementation in adolescents. J. 

A. CHURCH*; R. L. LEPORE; M. P. MCAVOY; F. M. MIEZIN; 

S. E. PETERSEN; S. A. BUNGE; B. L. SCHLAGGAR. 

Washington Univ. Sch. Med., Univ. of California, Berkeley. 

4:00 KKK17 501.12 Performance improving salient distractor 

activates left temporo-parietal junction in visual search. N. 

E. DIQUATTRO*; J. J. GENG. Ctr. for Mind & Brain, Dept. of 

Psychology, Univ. of California Davis. 

1:00 KKK18 501.13 Estimates of surface-based cortical 

networks using intrinsic functional connectivity from 1000 

subjects. B. YEO*; J. SEPULCRE; M. R. SABUNCU; D. 

LASHKARI; J. ROFFMAN; J. W. SMOLLER; B. FISCHL; H. 

LIU; R. BUCKNER. Dept. of Psychology and Ctr. for Brain 

Sci., Harvard Univ., Athinioula A. Martinos Ctr. for Biomed. 

Imaging, Dept. of Radiology, Computer Sci. and Artificial 

Intelligence Laboratory, Massachusetts Inst. of Technol., 

Howard Hughes Med. Inst. at Harvard Univ., Dept. of 

Psychiatry, Massachusetts Gen. Hosp. and Harvard Med. 

Sch., Ctr. for Human Genet. Research, Massachusetts Gen. 

Hosp., Div. of Hlth. Sci. and Technology, Massachusetts Inst. 

of Technol. 

2:00 KKK19 501.14 Anatomical and functional asymmetry in 

the cerebral cortex. R. SHAFEE*; H. LIU; M. SABUNCU; B. 

T. T. YEO; J. SEPULCRE; R. L. BUCKNER. Harvard Univ., 

Athinioula A. Martinos Ctr. for Biomed. Imaging, MIT, Howard 

Hughes Med. Inst. at Harvard Univ., Massachusetts Gen. 

Hosp. 

3:00 KKK20 501.15 Dorsal and ventral attention network 

engagement during memory retrieval processes as measured 

with functional MRI. S. A. MCMAINS*; S. KASTNER. 

Princeton Univ. 

4:00 KKK21 501.16 Estimates of cerebellar, thalamic and 

basal ganglia circuits using intrinsic functional connectivity 

from 1000 subjects. R. L. BUCKNER*; B. YEO; E. CHOI; J. 

SEPULCRE; M. R. SABUNCU; J. ROFFMAN; L. ZOLLEI; B. 

FISCHL; H. LIU; J. SMOLLER. HHMI at Harvard Univ., Dept. 

of Psychology, Harvard Univ., Athinioula A. Martinos Ctr. for 

Biomed. Imaging, Dept. of Radiology, Dept. of Psychiatry, 

Massachusetts Gen. Hosp. and Harvard Med. Sch., Computer 

Sci. and Artificial Intelligence Laboratory, Massachusetts Inst. 

of Technol., Div. of Hlth. Sci. and Technology, Massachusetts 

Inst. of Technol., Ctr. for Human Genet. Research, 


1:00 KKK22 501.17 Frontal and parietal cortex decide where to 

look. K. TARK*; C. E. CURTIS. Psychology, NYU, Psychology 

& CNS, NYU. 

2:00 KKK23 501.18 Gamma band spatiotemporal properties 

of top-down and bottom-up (emotion-based) attention in 

prefrontal, parietal, and anterior cingulate cortices: An MEG 

study. Q. LUO*; T. HOLROYD; H. YU; X. CHENG; J. BLAIR. 

NIH. 


Mon. PM

3:00 KKK24 501.19 Functional dissociation of lateral prefrontal 

cortex and dorsal network in the endogenous control of 

attention. C. L. ASPLUND*; R. MAROIS. Vanderbilt Univ. 

4:00 KKK25 501.20 Do congruency effects in the frontoparietal 

network reflect conflict processing or increased time 

on task? D. H. WEISSMAN*; J. M. CARP. Univ. Michigan. 

1:00 KKK26 501.21 Functional cortical activity and connectivity 

differs for males and females during attentionl control: A 

MEG examination. C. L. DALE; A. KAVEH; F. DARVAS; G. V. 

SIMPSON*; T. L. LUKS. Univ. of California, San Francisco, 

Univ. of Washington, BPI. 

2:00 KKK27 501.22 Distinct brain mechanisms underlying 

variation in attentional strategy. C. M. TIPPER*; S. T. 

GRAFTON. Univ. California, SB, Univ. of California, Santa 

Barbara. 

3:00 KKK28 501.23 State-dependent synchrony networks 

in humans revealed by TMS-EEG recordings. K. KITAJO*; 

Y. NAKAGAWA; Y. UNO; R. MIYOTA; M. SHIMONO; K. 

YAMANAKA; Y. YAMAGUCHI. RIKEN Brain Sci. Inst., 

PRESTO, Japan Sci. and Technol., The Univ. of Tokyo, 

Advanced Industrial Sci. and Technol., Showa Woman’s Univ. 

4:00 KKK29 501.24 A “Humpty-Dumpty” theory for why we 

dream. W. KLEMM*. Texas A&M Univ. Col. Vet Med. 

POSTER 

502. Typical and Disordered Language Development 



1:00 KKK30 502.1 Understanding the association between 

disturbances in prosody and social-relatedness in persons 

with Autism Spectrum Disorder. K. J. HOYTE*; B. S. 

PETERSON. Columbia Univ. 

2:00 KKK31 502.2 Functional connectivity in autistic and 

normal subjects during a language segmentation task. L. C. 

MOORE*; J. A. BROWN; D. SHIRINYAN; A. A. SCOTT-VAN 

ZEELAND; J. RUDIE; M. DAPRETTO; S. BOOKHEIMER. 

UCLA, Scripps Res. Inst. 

3:00 KKK32 502.3 An alternative route for speech production 

in developmental stuttering speakers. C. CAI*; K. MORI; S. 

OKAZAKI; M. OKADA. Natl. Rehabil. Ctr. For Persons With 

Disabilities, Res. Inst., Natl. Inst. for Physiological Sci. 

4:00 KKK33 502.4 Brain responses to cross-linguistic stimuli 

reveal atypical late discriminative processing of speech in 

children with dyslexia. K. LOHVANSUU; E. RUOHONEN; M. 

MAKI; P. H. LEPPANEN*. Univ. Jyvaskyla. 

1:00 KKK34 502.5 Lateralisation in the acallosal brain. A. 

BALL*; C. C. WOLF; S. OCKLENBURG; O. GUNTURKUN. 

Inst. For Cognitive Neurosci. 

2:00 KKK35 502.6 White matter callosal projections from 

superior temporal phonological regions predict reading skills in 

children. A. M. KEVAN*; L. M. PERRY; E. I. RYKHLEVSKAIA; 

M. BEN-SHACHAR; A. J. SHERBONDY; R. F. DOUGHERTY; 

B. A. WANDELL. Stanford Univ., Bar Ilan Univ. 

3:00 KKK36 502.7 Diffusion tensor imaging finds different 

patterns of associations between white matter microstructure, 

age and language skills in preterm and full-term children. E. 

S. LEE; J. D. YEATMAN; R. BAMMER; H. M. FELDMAN*. 



4:00 KKK37 502.8 An fMRI investigation of individual 

differences in auditory sentence comprehension in adolescent 

children born prematurely. L. H. BARDE*; J. D. YEATMAN; E. 

S. LEE; G. H. GLOVER; H. M. FELDMAN. Stanford Univ. Sch. 

of Med. 

1:00 KKK38 502.9 Investigating the neuroplasticity of 

language processing: Recovering from acquired childhood 

aphasia (ACA). M. LAUTERBACH*; R. GIL DA COSTA; G. 

LEAL; I. PAVÃO MARTINS. Fac. of Med., The Salk Inst. for 

Biol. Studies, Hosp. Santa Maria. 

2:00 KKK39 502.10 An fMRI study of language reorganization 

following early neurological disease and neurosurgery. M. E. 

TIVARUS*; S. DAVIS; E. L. NEWPORT; G. BADYULINA; J. T. 

LANGFITT. Univ. of Rochester. 

3:00 KKK40 502.11 Prefrontal development and processing 

of various word orders in child Japanese. T. YAMAMOTO*; 

Y. NISHIMURA; K. SUGISAKI; N. HATTORI; Y. INOKUCHI; 

M. KOMACHI; Y. NISHIMURA; Y. OTSU; M. OGAWA; M. 

OKADA; S. UMEDA; K. TAMARI; E. YOSHIDA; S. AYANO. 

Mie Univ. Grad.Sch.Med., Shizuoka Univ., Suzuka Univ. of 

Med. Sci., Keio Univ. 

4:00 KKK41 502.12 • Neural correlates of syntactic processing 

in monolingual and bilingual children using event-related 

functional near infrared spectroscopy (fnirs) imaging. K. 

JASINSKA; M. MALKOWSKI; L. PETITTO*. Univ. of Toronto. 

1:00 KKK42 502.13 Lexico-semantic processes indexed by the 

infant N400m rely on similar left frontotemporal areas as in 

adults. K. E. TRAVIS*; M. K. LEONARD; T. T. BROWN; D. J. 

HAGLER, Jr.; M. M. CURRAN; A. M. DALE; J. L. ELMAN; E. 

HALGREN. UCSD. 

2:00 KKK43 502.14 Developmental changes in the inferior 

frontal cortex for selecting semantic representations. S. 

LEE*; J. R. BOOTH; S. CHEN; T. CHOU. Psychology 

Department, Natl. Taiwan Univ., Dept. of Communication Sci. 

and Disorders, Northwestern Univ., Dept. of Early Childhood 

Education, Taipei Municipal Univ. of Educ. 

3:00 KKK44 502.15 � Functional connectivity of Broca’s area 

in children and adults. J. K. ORAM*; P. SHIH; E. N. MOORE 

PARKS; E. L. BURNS; R. MUELLER. San Diego State Univ., 

Joint Doctoral Program in Clin. Psychology, San Diego State 

Univ. and Univ. of California San Diego. 

4:00 KKK45 502.16 Neural bases of frequency perception 

in language in children and adults. I. KOVELMAN*; K. K. 

MASCHO; A. L. MASTIC; L. ADATO; S. E. SPATH. Univ. of 

Michigan. 

1:00 KKK46 502.17 Relating neural activity in languagerelevant 

networks to cortical maturation during typical 

development. Y. HAN*; K. MCNEALY; E. KAN; V. SHIH; E. 

SOWELL; M. DAPRETTO. UCLA. 

2:00 KKK47 502.18 Word intelligibility and age predict visual 

cortex activity during word listening. S. E. KUCHINSKY; K. 

VADEN; N. I. KEREN; K. C. HARRIS; J. B. AHLSTROM; J. R. 

DUBNO; M. A. ECKERT*. Med. Univ. South Carolina. 

3:00 KKK48 502.19 Correct or incorrect? Performance-related 

differences in activation during morphosyntactic judgment in 

children. M. L. DIANO*; E. L. BURNS; E. N. MOORE-PARKS; 

R. MUELLER. San Diego State Univ., Brain Develop. Imaging 

Laboratory, San Diego State Univ., Brain Develop. Imaging 

Laboratory, San Diego State University, Joint Doctoral 

Program UCSD/SDSU. 

4:00 KKK49 502.20 Processing of case marking information 

in the developing brain. L. J. KNOLL*; A. D. FRIEDERICI; J. 

BRAUER. Max-Planck Inst. 



1:00 KKK50 502.21 • Mechanisms of brain plasticity. A. 

UTTER; B. KUNDU; T. A. GALLAGHER; J. WOOD; J. 

VOSS; V. A. NAIR; N. L. HTET; S. VYSOTSKI; D. BANIULIS; 

D. HUSS; N. KORNDER; C. MADURA; A. ATASSI; C. 

H. MORITZ; J. S. KUO; A. S. FIELD; B. MEYERAND; V. 

PRABHAKARAN*. Univ. of Wisconsin, Univ. of Wisconsin 

Hosp. and Clinics. 

POSTER 

503. Decision Making: Perception, Cognition, Neural 

Corrrelates 



1:00 KKK51 503.1 • Brain activity and network in economic 

decision-making. B. LAMICHHANE; B. M. ADHIKARI; S. 

BROSNAN; M. DHAMALA*. Georgia State. 

2:00 KKK52 503.2 Decision-making, errors, and confidence 

in the brain. E. T. ROLLS*; F. GRABENHORST; G. DECO. 

Oxford Ctr. For Comp Neurosci., Cambridge Univ., Pompeu 

Fabra Univ. 

3:00 KKK53 503.3 Direct estimation of decision uncertainty 

and its neural correlates in human brain. K. CHOE*; S. LEE. 

Seoul Natl. Univ. 

4:00 KKK54 503.4 Emulation of other’s reward prediction 

error in social value-based decision making. S. SUZUKI; 

N. HARASAWA*; K. UENO; S. KAVERI; J. L. GARDNER; 

N. ICHINOHE; M. HARUNO; K. CHENG; H. NAKAHARA. 

Lab. For Int Theor Neurosci, RIKEN BSI, fMRI Support Unit, 

RIKEN BSI, Dept Comp Intelli & Sys Sci, Tokyo Inst. of Tech., 

Gardner Res. Unit, RIKEN BSI, Dept Neuroanatomy, Hirosaki 

Univ., Brain Sci. Institute, Tamagawa Univ., Lab. for Cognitive 

Brain Mapping, RIKEN BSI. 

1:00 KKK55 503.5 Changes of mind during binary and 

multiple-choice decision-making. L. ALBANTAKIS*; F. 

BRANZI; C. MARTIN; A. COSTA; G. DECO. UPF Barcelona, 

Institució Catalana de Recerca i Estudis Avançats (ICREA). 

2:00 KKK56 503.6 • Dynamical mechanism for multiple-choice 

decision making. D. WANG*; H. YOU. Beijing Normal Univ. 

3:00 KKK57 503.7 An effect of time pressure on perceptual 

decision-making. S. KIRA*; M. N. SHADLEN. Univ. of 

Washington, HHMI, Natl. Primate Res. Center, Univ. of 

Washington. 

4:00 KKK58 503.8 Neural correlates of evidence 

accumulation in perceptual decision making. T. LIU*; T. J. 

PLESKAC. Michigan State Univ. 

1:00 KKK59 503.9 The optimality of sensory encoding during 

speeded perceptual decision making. T. C. HO*; S. BROWN; 

J. T. SERENCES. UCSD, Univ. of Newcastle, Australia. 

2:00 KKK60 503.10 New consumer decision making model 

by “Information effect” and experiments in actual stores by 

national brand product. Y. KOSAKA*. Oracle Co, LTD. 

3:00 KKK61 503.11 Inferences from memory: The biological 

basis of heuristic decision making. P. H. KHADER*; T. 

PACHUR; S. MEIER; S. BIEN; K. JOST; F. RÖSLER. Philipps- 

University, Univ. of Basel, RWTH Aachen Univ. 

4:00 KKK62 503.12 Learning to decide when to decide. M. 

AHMADI*; P. E. LATHAM. UCL, Gatsby Computat. Neurosci. 

Unit. 



1:00 KKK63 503.13 Physiological function and decision 

making in different motor tasks. A. A. BUTLER*; R. 

FITZPATRICK. Prince of Wales Med. Res. Inst. 

2:00 KKK64 503.14 Optimal decision-making and inhibitory 

control in the stop-signal task: Go and stop latencies both 

depend on go stimulus difficulty. P. SHENOY*; J. SCHILZ; A. 

J. YU. UCSD. 

3:00 KKK65 503.15 Messages driving risky behavior modulate 

decision-related activity in the anterior cingulate cortex, insula 

and ventromedial prefrontal cortex. R. FUKUNAGA*; A. 

KRAWITZ; J. W. BROWN. Indiana Univ. 

4:00 KKK66 503.16 Neural correlates of framing effects in 

adolescent decision-making. L. VAN LEIJENHORST*; K. M. 

MCGLENNEN; A. GALVAN. UCLA. 

1:00 KKK67 503.17 Statistical learning across trials and 

reward-driven decision-making within trials in an active 

visual search task: Comparison of human behavioral data to 

Bayes-optimal sensory processing and saccade planning. H. 

HUANG*; A. J. YU. UCSD. 

POSTER 

504. Cognitive Aging: Encoding and Memory 



1:00 KKK68 504.1 Spatial memory impairment in human 

aging: contribution of allocentric and egocentric strategies 

in a virtual environment. N. BETBEDER; J. DALRYMPLE- 

ALFORD; B. BONTEMPI*. CNRS UMR 5228, Univ. of 

Canterbury. 

2:00 KKK69 504.2 Internet training alters working memory 

neural circuitry in older adults. H. GADDIPATI*; T. D. MOODY; 

D. SHIRINYAN; G. W. SMALL; S. Y. BOOKHEIMER. UCLA. 

3:00 KKK70 504.3 � Age-related differences in verbal and 

visual working memory. E. HERNÁNDEZ-RAMOS*; P. 

TREJO; S. CANSINO. Lab. of NeuroCognition, Fac. of 

Psychology, Natl. Autonomous Univ. of Mexico. 

4:00 LLL1 504.4 Frontotemporal connections, ageing and 

episodic memory: A diffusion tensor MRI tractography study. 

C. METZLER-BADDELEY*; A. PALMER; J. P. AGGLETON; S. 

D. VANN; D. K. JONES; M. O’SULLIVAN. Cardiff Univ., Cardiff 

Univ. Brain Res. Imaging Ctr. (CUBRIC). 

1:00 LLL2 504.5 • Age-related differences in inter- and intrahemispheric 

connectivity in prefrontal cortex during rs-fMRI. 

T. B. MEIER*; A. S. DESHPANDE; J. C. MOTZKIN; D. G. 

MCLAREN; J. C. WILDENBERG; D. TUDORASCU; V. A. 

NAIR; V. SINGH; X. ZHU; G. R. KIRK; J. M. OLLINGER; J. B. 

NITSCHKE; A. L. ALEXANDER; R. M. BIRN; B. B. BISWAL; 

M. E. MEYERAND; V. PRABHAKARAN. Univ. of Wisconsin- 

Madison, William S. Middleton Mem. Veteren’s Hosp., Univ. of 

Med. and Dent. of New Jersey. 

2:00 LLL3 504.6 Diastolic blood pressure and 

antihypertensive medication use modulate immediate and 

delayed recall during hyperinsulinemic-euglycemic clamp. L. 

BONNER; G. WATSON*; M. ARBUCKLE; L. D. BAKER; C. L. 

BRYSON; S. CRAFT. VA Puget Sound Healthcare Syst., Univ. 

of Washington. 

3:00 LLL4 504.7 The effects of healthy aging on feedbackbased 

learning and generalization. E. BRAUN*; K. FOERDE; 

N. CLEMENT; K. JOHNSON; D. SHOHAMY. Columbia Univ. 


Mon. PM

4:00 LLL5 504.8 Episodic memory function is associated 

with multiple measures of white matter integrity. S. N. 

LOCKHART*; A. B. V. MAYDA; A. E. ROACH; E. FLETCHER; 

O. CARMICHAEL; C. DECARLI. Univ. of California Davis. 

1:00 LLL6 504.9 Age differences in the neural 

representation of working memory revealed by multi-voxel 

pattern analysis. J. M. CARP*; L. GMEINDL; P. A. REUTER- 

LORENZ. Univ. of Michigan, Johns Hopkins Univ. 

2:00 LLL7 504.10 Processing speed accounts for age 

group differences in working memory-related performance 

and neural activity. I. J. BENNETT*; H. G. RIVERA; M. A. E. 

COLBY; M. KARNIK-HENRY; B. RYPMA. Ctr. For Brainhealth, 

Univ. of Texas at Dallas, Univ. of Texas Southwestern Med. 

Ctr. 

3:00 LLL8 504.11 Reduced deactivation during episodic 

memory encoding is related to resting state functional 

connectivity in aging. E. C. MORMINO*; A. SMILJIC; A. 

HAYENGA; C. M. MADISON; S. L. BAKER; W. J. JAGUST. 

UC Berkeley, HWNI, Lawrence Berkeley Natl. Lab. 

4:00 LLL9 504.12 Neural correlates of encoding activity 

across the lifespan. H. PARK*; K. KENNEDY; K. RODRIGUE; 

A. HEBRANK; B. FLICKER; D. C. PARK. Univ. of Texas- 

Arlington, Univ. of Texas-Dallas. 

1:00 LLL10 504.13 • Analysis of cognitive performance in 

a worldwide sample of over 200,000 people reveals new 

distinctions in age-related cognitive decline. J. HARDY*; M. 

SCANLON. Lumos Labs. 

2:00 LLL11 504.14 The neural correlates underlying agerelated 

differences in effective filtering of distracting visual 

information. H. BURIANOVÁ*; S. EMRICH; L. HASHER; 

C. GRADY; S. FERBER. Macquarie Univ., Univ. of Toronto, 

Rotman Res. Inst. 

3:00 LLL12 504.15 Effects of age on the neural correlates of 

successful source memory encoding. J. T. MATTSON*; T. H. 

WANG; M. D. RUGG. Univ. of California-Irvine. 

POSTER 

505. Timing and Temporal Processing: human Studies 



1:00 LLL13 505.1 Cerebellar contribution to perceptual 

learning generalization. P. R. SERVOS*; P. J. PLANETTA; T. 

BANCROFT; D. V. MEEGAN. Wilfrid Laurier Univ., Univ. of 

Guelph. 

2:00 LLL14 505.2 Duration-numerosity interaction in 

human prefrontal cortex. M. J. HAYASHI*; H. C. TANABE; Y. 

YOSHIDA; N. SADATO. Grad. Univ. Advanced Studies, Natl. 

Inst. for Physiological Sci., Univ. of Fukui. 

3:00 LLL15 505.3 Where is the internal clock within the 

cerebral cortex? R. KOSHIZAWA*; A. MORI; T. OZAWA; M. 

TAKAYOSE; Y. KITA. Grad Sch. of Lit & Soc Sci, Nihon Univ., 

Keisen Univ. Fac Humanities. 

4:00 LLL16 505.4 Quantifying the stimulus-specificity and 

time-locking of spatiotemporal spike patterns. O. F. JURJUT; 

D. NICOLIC; W. SINGER; C. WEBER*; R. C. MURESAN. 

Frankfurt Inst. for Advanced Studies, Max-Planck-Institut für 

Hirnforschung, Univ. Hamburg, Ctr. for Cognitive and Neural 

Systems. 


1:00 LLL17 505.5 • A comparison between the performance 

of normal and ADHD children in a temporal bisection task. 

A. M. BALBOA-VERDUZCO; D. VELÁZQUEZ-LÓPEZ; D. 

VELAZQUEZ-MARTINEZ*. Inst. Politecnico Nacional, Univ. 

Nacional Autónoma de Mexico, UNAM. 

2:00 LLL18 505.6 Neural responses involved in adaptation 

induced blindness. K. AMANO*; T. TAKAHASHI; T. TAKEDA; 

I. MOTOYOSHI. Univ. Tokyo, Keio Univ., NTT Communication 

Sci. Labs. 

3:00 LLL19 505.7 Eye-tracking and subjective time 

perception in images of different body positions reduced to 

lines. F. C. NATHER*; J. BUENO. Univ. of São Paulo. 

4:00 LLL20 505.8 Neural substrates of time perception and 

impulsivity. M. WITTMANN*; A. N. SIMMONS; T. FLAGAN; S. 

D. LANE; J. WACKERMANN; M. P. PAULUS. IGPP, Univ. of 

California San Diego, Univ. of Texas Hlth. Sci. Ctr. 

1:00 LLL21 505.9 The brain activity associated with time 

perception: A comparison between MEG and EEG signals. 

A. Y. CHANG; W. LIANG; C. LIN*; O. J. TZENG; D. H. WU. 

Academia Sinica, Natl. Yang-Ming Univ., Natl. Central Univ., 

Natl. Cheng Kung Univ. 

2:00 LLL22 505.10 Synchronization of movement between 

musicians. G. P. MOORE*; J. CHEN. USC, New York Univ. 

Sch. of Med. 

3:00 LLL23 505.11 A local-circuit cortical model supports 

timing in the hundreds of milliseconds range. D. STANDAGE*; 

M. DORRIS. Queen’s Univ. 

4:00 LLL24 505.12 The same fundamental carrier frequencies 

underlie evoked and intrinsic communication. A. S. 

GHUMAN*; R. N. VAN DEN HONERT; A. MARTIN. NIMH. 

1:00 LLL25 505.13 Rhythmically presented stimuli modulate 

oscillatory alpha activity. K. W. DORON*; M. R. JONES; H. 

HINRICHS; M. S. GAZZANIGA. Univ. of California, Ohio State 

Univ., Univ. of Magdeburg. 

2:00 LLL26 505.14 The cerebellum and premotor cortex 

are differentially implicated in error-feedback and exemplar 

based training respectively on a temporal judgment task. D. 

E. CALLAN*; N. SCHWEIGHOFER; M. KAWATO; M. SATO. 

ATR Neural Information Analysis Labs., Biokinesiology and 

Physical Therapy, Univ. of Southern California, ATR Computat. 

Neurosci. Labs. 

3:00 LLL27 505.15 A role for the executive control network in 

time projection during the resting-state. E. L. DENNIS*; M. E. 

THOMASON; I. H. GOTLIB. UCLA Neurosci. IDP, Stanford 

Univ. 

4:00 LLL28 505.16 Gesture in time - How temporal alignment 

affects gesture-speech integration. C. OBERMEIER*; M. 

GRIGUTSCH; T. C. GUNTER. Max Planck Inst. for Human 

Cognitive and Brain Sci. 

1:00 LLL29 505.17 The anatomical structure of human 

sensory cortices predicts temporal ability. S. GILAIE-DOTAN*; 

R. KANAI; G. REES. UCL. 

2:00 LLL30 505.18 Temporal reproduction in stimulus-based 

and intention-based action. T. HERAI*; K. MOGI. Tokyo Inst. 

Technol., Sony Computer Sci. Labs. 

3:00 LLL31 505.19 A comparison of two neuropsychological 

tests evaluating deficits in processing speed in patients with 

multiple sclerosis. A. J. HUGHES*; D. R. DENNEY; S. G. 

LYNCH. Univ. of Kansas, Univ. of Kansas Med. Ctr. 



4:00 LLL32 505.20 Non-invasive tracing of functional brain 

activation within frontal and temporal lobes using combined 

EEG and NIRS. L. NAJAFIZADEH; A. MEDVEDEV; 

F. AMYOT; J. KAINERSTORFER; J. D. RILEY; E. M. 

WASSERMANN; A. GANDJBAKHCHE*. Henry Jackson 

Fndn., Georgetown Univ., NIH. 

1:00 LLL33 505.21 Deficit in interval timing as an 

endophenotype for attention-deficit hyperactivity disorder. S. 

S. GAU*. Natl. Taiwan Univ. Hosp. & Col. of Med. 

2:00 LLL34 505.22 Offline improvement occurs for temporal 

stability but not accuracy following practice of integer and noninteger 

rhythm production. D. L. WRIGHT*; J. RHEE. Texas 

A&M Univ. 

3:00 LLL35 505.23 Genetically determined differences in time 

perception. M. WIENER*; F. W. LOHOFF; H. B. COSLETT. 

Univ. Pennsylvania. 

4:00 LLL36 505.24 Brain basis of expectancy in musical 

cadence perception. M. H. THAUT*; B. J. SPIERING; C. 

ALPETER; S. I. QURAINI; A. G. SARES; C. SEGER. 

Colorado State Univ. 

1:00 LLL37 505.25 Differential coherence between 

polysensory cortical areas during an audio-visual search and 

track task. T. D. ARD*; D. RUBINSTEIN; T. HOLROYD; F. 

CARVER; R. COPPOLA. NIH. 

2:00 LLL38 505.26 The influence of target eccentricity on 

ipsilateral and contralateral responses. T. Y. KWON; J. M. 

HONDZINSKI*. LSU. 

3:00 LLL39 505.27 • The influence of stimulus novelty and 

experimental context on duration perception. M. CAI*; V. 

PARIYADATH; W. MA; D. M. EAGLEMAN. Baylor Col. of Med. 

4:00 LLL40 505.28 Unconscious detection of change 

indicated by presence of p300 response. R. T. TANOUE*; T. A. 

AVINO; A. T. KARST. Univ. of Nevada, Reno. 

POSTER 

506. Neural Mechanisms and Pharmacology: Underlying 

Attention 



1:00 LLL41 506.1 GABAergic modulation of nicotine-evoked 

cholinergic transients in prefrontal cortex. A. S. BERRY*; H. 

GRITTON; M. M. ST. PETERS; L. DEPOLO; M. SARTER. 


2:00 LLL42 506.2 Effects of prenatal nicotine exposure 

on neurotransmitters and neurobehaviors in offspring of 

C57BL/6J mice. T. ALKAM*; T. MAMIYA; M. HIRAMATSU; N. 

A. DARMANI; T. NABESHIMA. Meijo Univ. Grad Sch. Pharm, 

Western Univ. of Hlth. Sci. 

3:00 LLL43 506.3 Acetylcholine mediates turtle attention. 

A. S. POWERS*; V. M. NAIMOLI. St John’s Univ., Sanofi- 

Aventis. 

4:00 LLL44 506.4 Deficits in prepulse inhibition after 

excitotoxic dorsomedial striatal lesions, but not after 

dorsolateral lesions, in mice. L. C. BALDAN RAMSEY*; M. 

XU; C. PITTENGER. Yale Univ. 

1:00 LLL45 506.5 Centrally administered orexin A attenuates 

visual distracter-related deficits in rats. J. A. BURK*; K. E. 

EASTERLING; J. R. FADEL. Col. of William & Mary, Univ. of 

South Carolina Sch. of Med. 



2:00 LLL46 506.6 Mouse pharmacological models of 

impaired vigilance in schizophrenia. J. W. YOUNG*; S. B. 

POWELL; S. ERHARDT; M. HOLTZE; M. A. GEYER. UCSD, 

Karolinska Inst. 

3:00 LLL47 506.7 Lasting synaptic changes underlie 

attention deficits caused by nicotine exposure during 

adolescence. D. S. COUNOTTE*; N. A. GORIOUNOVA; 

K. W. LI; M. LOOS; R. C. VAN DER SCHORS; A. N. M. 

SCHOFFELMEER; A. B. SMIT; H. D. MANSVELDER; T. 

PATTIJ; S. SPIJKER. Univ. of Maryland Baltimore, VU Univ. 

Amsterdam, VU Univ. medical center. 

4:00 LLL48 506.8 Nicotine restores attentional deficits and 

increases plasticity within the prefrontal cortex of beta 2 

knockout mice. K. GUILLEM*; J. TIMMERMAN; S. SPIJKER; 

H. D. MANSVELDER. VU Univ. Amsterdam, CNCR. 

1:00 LLL49 506.9 Novel object recognition and social 

interaction in rats lacking cortical cholinergic innervation; 

comparing manual and digital video tracking systems. S. T. 

SAVAGE*; L. OLSON; A. MATTSSON. Karolinska Inst. 

2:00 LLL50 506.10 Chronic methylphenidate treatment alters 

PFC neuron baseline activity. N. DAFNY*; P. B. YANG; A. 

CHELARU. Univ. Texas Med. Sch. 

3:00 LLL51 506.11 Medial prefrontal and orbitofrontal regions 

of rat cortex are innervated by distinct populations of locus 

coeruleus neurons. D. J. CHANDLER*; K. L. AGSTER; R. K. 

VASUDEVA; J. A. MCGAUGHY; B. D. WATERHOUSE. Drexel 

Univ. Col. of Med., Univ. of New Hampshire. 

4:00 LLL52 506.12 Mesolimbic-basal forebrain circuitry 

mediating the motivational activation of attention. M. M. ST. 

PETERS*; J. P. BRUNO; M. SARTER. Univ. Michigan, Ohio 

State Univ. 

1:00 LLL53 506.13 P2Y1 nucleotide receptor stimulation in 

the prefrontal cortex impairs working memory. U. KRUGEL*; 

H. FRANKE; H. KOCH. Univ. Leipzig. 

2:00 LLL54 506.14 The effects of long-term ovariectomy 

on latent inhibition and anxiety-like behavior in rats. S. 

HOROVITZ*; A. BIEGON; I. WEINER. The Joseph Sagol 

Neurosci. Ctr., Tel Aviv Univ., Brookhaven Natl. Lab. 

3:00 LLL55 506.15 The metabotropic mGlu5 receptor positive 

allosteric modulator, CDPPB, enhances social discrimination 

in a developmental model of schizophrenia, neonatal 

phencyclidine-treated rats. N. MORISOT; S. GIRARDON; M. 

J. MILLAN*; F. LOISEAU. Inst. Recherche Servier. 

4:00 LLL56 506.16 • Basal forebrain TrkA receptor knockdown 

produces attenuated cortical cholinergic transmission and 

enduring impairments in attentional performance. V. V. 

PARIKH*; W. M. HOWE; R. M. WELCHKO; D. E. D’AMORE; 

D. L. TURNER; M. SARTER. Temple Univ., Univ. of Michigan. 

1:00 LLL57 506.17 • Modulation of cholinergic transients 

mediating cue detection and detection performance. J. D. 

GIETZEN*; W. M. HOWE; M. DECKER; M. SARTER. Univ. of 

Michigan, Abbott Labs. 

2:00 LLL58 506.18 Effect of ethanol on attentional function 

of rhesus macaques. H. P. JEDEMA*; M. CARTER; B. P. 

DUGAN; K. GURNSEY; C. W. BRADBERRY. Univ. Pittsburgh, 

VA Pittsburgh Hlth. Services, Ctr. for Neurosci. 

3:00 LLL59 506.19 Long lasting increases in distractibility in 

rhesus monkeys following chronic cocaine self-administration. 

J. N. PORTER*; H. P. JEDEMA; B. P. DUGAN; G. GOMEZ; K. 

GURNSEY; C. W. BRADBERRY. Univ. of Pittsburgh, Ctr. for 

the Neural Basis of Cognition, VA Pittsburgh Hlth. Services. 


Mon. PM

4:00 LLL60 506.20 � Sleep dysregulation and impaired 

cognition in rhesus monkeys following chronic cocaine self 

administration. G. GOMEZ*; H. P. JEDEMA; K. GURNSEY; 

C. W. BRADBERRY. Univ. of Pittsburgh, VA Pittsburgh Hlth. 

Services. 

1:00 LLL61 506.21 The effects of low dose methylphenidate 

and noradrenergic antagonists on stimulus-driven neuronal 

activity in the rodent lateral geniculate nucleus. K. L. 

AGSTER*; B. D. CLARK; B. D. WATERHOUSE. Drexel Univ. 

- Coll Med. 

2:00 LLL62 506.22 Analysis of the effects of a CB1 agonist 

on visuospatial discrimination in rats: Role of alterations 

in responding between trials. R. L. A. MILLER; J. P. BOW; 

W. N. STEWART; E. E. THOMPSON; G. A. THAKUR; A. 

MAKRIYANNIS; P. J. MCLAUGHLIN*. Edinboro Univ. of 

Pennsylvania, Northeastern Univ. 

3:00 LLL63 506.23 • A unique cognitive enhancing effect of 

lurasidone in object retrieval with detours, a test of executive 

function in non-human primates. K. IKEDA; T. MURAI; T. 

TSUJIMURA; T. FUKUOKA; M. IKEJIRI; K. HOSHINO; T. 

ISHIYAMA*; J. KIMURA; M. TAIJI. Dainippon Sumitomo 

Pharma, Co., Ltd. 

4:00 LLL64 506.24 Effects of non-pharmacological 

manipulations on behavior in the 5-choice serial reaction time 

task. M. S. GALLO; A. T. KNOLL; C. L. NEMETH; T. A. PAINE; 

J. M. MUSCHAMP; B. M. COHEN; W. A. CARLEZON*, Jr. 


1:00 LLL65 506.25 Medial prefrontal modulation of the 

nucleus basalis magnocellularis during attention-dependent 

learning. V. Y. GREENFIELD*; M. S. CARBAJAL; A. CORTEZ; 

L. HORN; B. KINNEY-HURD; S. PODOLAK; J. VALENTINE; 

J. VAN CAMPEN; A. BUTT. CSUSB. 

2:00 LLL66 506.26 Environmental enrichment attenuates 

impairments in attention-dependent learning following early 

or late lesions of the nucleus basalis magnocellularis. A. E. 

BUTT*; S. PODOLAK; B. KINNEY-HURD; V. GREENFIELD; 

J. VALENTINE; J. VAN CAMPEN; M. S. CARBAJAL. 

California State Univ. 

3:00 LLL67 506.27 Spatial attention in chickens. E. I. 

KNUDSEN*; S. DEVARAJAN; A. KAING; P. KNUDSEN. 

Stanford Univ. Sch. Med. 

POSTER 

507. Schizophrenia: Anxiety, Vocalization, Environment 



1:00 LLL68 507.1 The rodent neonatal PCP model 

recapitulates core features of schizophrenia. A. E. EASTON*; 

K. JONES; S. DIGAVALLI; P. CHEN; J. CORRADI; N. 

BARREZUETA; Y. LI; A. CACACE; L. BRISTOW. Bristol 

Myers Squibb. 

2:00 LLL69 507.2 Concussive brain injury in juvenile rats 

results in sustained increases in anxiety behavior. R. A. 

LASKOWSKI*, II; D. P. FOX; R. RAGHUPATHI. Drexel Univ. 

Col. of Med. 

3:00 LLL70 507.3 • Dopamine D1 and D2 family receptor 

agonist effects on mouse working memory capacity. I. S. 

TARANTINO; M. A. GEYER; J. L. EVENDEN*; J. W. YOUNG. 

Dept of Psychiatry, Wiltonlogic. 


4:00 MMM1 507.4 Executive function is altered in the adult 

offspring of rats exposed to a viral mimetic during pregnancy. 

Y. ZHANG*; J. G. HOWLAND. Neural Systems and Plasticity 

Res. Group; Univ. of Saskatchewan. 

1:00 MMM2 507.5 Do outbred ICR mice form attentional 

sets in a bait digging set-shifting procedure? A. LINDEN*; C. 

PROCACCINI; M. TÖRNÄVÄ. Inst. of Biomedicine, Univ. of 

Helsinki. 

2:00 MMM3 507.6 Manipulation of host behavior: Effects of 

chronic Toxoplasma infection. C. M. AFONSO*; R. M. COSTA. 

Inst. Gulbenkian Ciencia. 

3:00 MMM4 507.7 Knock-down of disrupted in schizophrenia 

1 (DISC1) in the rat prefrontal cortex lowers the threshold 

for stress-induced cognitive dysfunction. N. J. GAMO*; C. 

D. PASPALAS; A. KATA; L. BOVEN; C. J. BRYAN; T. LO; 

K. ANIGHORO; L. BERMUDEZ; K. PENG; A. ANNOR; 

S. TAYLOR; K. PATEL; A. DUQUE; A. A. SIMEN; A. F. T. 

ARNSTEN. Yale Univ. 

4:00 MMM5 507.8 Alpha7 nicotinic receptor influences on 

prefrontal cortex (PFC) network physiology. Y. YANG*; N. 

GAMO; A. ARNSTEN; M. WANG. Yale Univ. 

1:00 MMM6 507.9 Changes in dorsolateral prefrontal cortex 

neuronal physiology with advancing age: Decline in persistent 

firing during working memory. M. WANG*; N. J. GAMO; Y. 

YANG; J. MAZER; D. LEE; A. F. T. ARNSTEN. Yale Univ. Sch. 

of Med. 

2:00 MMM7 507.10 Reducing prefrontal cortical GABA 

activity induces cognitive, behavioral and dopaminergic 

abnormalities that resemble those observed in schizophrenia. 

T. ENOMOTO*; M. T. L. TSE; S. B. FLORESCO. Dainippon 

Sumitomo Pharma Co., Ltd., Univ. British Columbia. 

3:00 MMM8 507.11 Repeated amphetamine exposure disrupts 

decision making with conditioned punishment. A. CANTOR*; 

S. B. FLORESCO. Univ. of British Columbia, Univ. British 

Columbia. 

4:00 MMM9 507.12 Involvement of the medial orbitofrontal 

cortex in risk and delay-based decision making. E. B. 

GREEN*; C. M. STOPPER; S. B. FLORESCO. Douglas 

Kenny Building, Univ. British Columbia. 

1:00 MMM10 507.13 Distinct local field potential responses 

in the ventral tegmental area to the appetitive and aversive 

conditioned stimuli. Y. KIM*; B. MOGHADDAM. Univ. 

Pittsburgh. 

2:00 MMM11 507.14 The domestic dog model: Observation of 

human-dog social interactions relevant to neurodevelopmental 

disorders. L. LIT*; A. M. OBERBAUER. Univ. California Davis, 

Univ. of California Davis. 

3:00 MMM12 507.15 What makes a successful song for a 

nightingale? T. C. ROESKE*; P. SPRAU; D. ROTHENBERG; 

G. F. MARCUS; O. TCHERNICHOVSKI; M. NAGUIB. Dept. of 

Biology, MR 701, Netherlands Inst. of Ecology (NIOO-KNAW), 

New Jersey Inst. of Technol., New York Univ., The City Col. of 

New York. 

4:00 MMM13 507.16 Effects of face and motion stimuli on 

auditory processing in the ventrolateral prefrontal cortex. 

J. HWANG*; L. M. ROMANSKI. Univ. Rochester, Univ. of 

Rochester Sch. of Med. 

1:00 MMM14 507.17 Neuronal activity in the primate ventral 

frontal lobe during discrimination tasks of emotional faces and 

vocalizations. M. M. DIEHL*; M. D. DILTZ; L. M. ROMANSKI. 

Univ. Rochester SMD. 



2:00 MMM15 507.18 The effects of variable housing conditions 

on home cage behavior in c57bl/6j mice. P. HECHT*; K. 

JONES; D. BEVERSDORF; M. WILL. Univ. of Missouri- 

Columbia. 

3:00 MMM16 507.19 Dissociable pro-cognitive contributions of 

social interaction and environmental enrichment on cognitive 

flexibility in developing male rats. S. K. SALAND*; J. S. 

RODEFER. Florida State Univ. 

POSTER 

508. Impulse Control Disorders: Attentional Impairments 



1:00 MMM17 508.1 Making “slackers” work and “workers” 

slack: Basolateral amygdala inactivations alter choice 

preferences in a rodent model of cognitive effort. J. 

HOSKING*; P. J. COCKER; C. A. WINSTANLEY. Kenny 

Psychology, Univ. of British Columbia. 

2:00 MMM18 508.2 The reinforcing side of failure: Modeling 

near miss events in a novel rodent slot machine task. P. J. 

COCKER*; C. A. WINSTANLEY. Univ. of British Columbia. 

3:00 MMM19 508.3 Lesions to the basolateral amygdala 

and orbitofrontal cortex differentially affect acquisition and 

performance of a rodent gambling task. F. D. ZEEB*; C. A. 

WINSTANLEY. Univ. of British Columbia. 

4:00 MMM20 508.4 Variation in attributing incentive salience to 

a food cue is associated with action impulsivity. V. LOVIC*; B. 

T. SAUNDERS; L. M. YAGER; A. K. CZUJ; T. E. ROBINSON. 


1:00 MMM21 508.5 The effect of ventral hippocampal lesions 

on discrimination and reversal learning. A. R. ABELA*; C. 

HILL; Y. CHUDASAMA. McGill Univ. 

2:00 MMM22 508.6 Hippocampal-prefrontal cortical 

circuits subserve inhibitory response control in the rat. Y. 

CHUDASAMA*; V. M. DOOBAY; Y. LIU. McGill Univ. 

3:00 MMM23 508.7 Selective lesions of the thalamic reuniens 

in rats increase impulsive responses in the 5-choice 

reaction time task. J. A. PRASAD*; E. M. MACGREGOR; Y. 

CHUDASAMA. McGill Univ. 

4:00 MMM24 508.8 Caffeine regulates corticostriatal dopamine 

transporter density and improves attentional deficits in an 

animal model of attention deficit hyperactivity disorder. P. 

PANDOLFO*; N. MACHADO; A. KOFALVI; R. A. CUNHA; 

R. N. TAKAHASHI. Univ. of Coimbra, Federal Univ. of Santa 

Catarina. 

1:00 MMM25 508.9 Deletion of the alpha-synuclein gene 

decreases motor impulsivity in mice. Y. PENA-OLIVER*; V. L. 

BUCHMAN; T. L. RIPLEY; D. N. STEPHENS. Univ. of Sussex, 

Cardiff Univ. 

2:00 MMM26 508.10 • Beta-adrenoceptor-mediated action of 

atomoxetine during behavioral inhibition on the stop-signal 

task in rats. D. M. EAGLE*; K. R. DAVIES; B. W. TOWSE; 

J. F. KEELER; D. E. THEOBALD; T. W. ROBBINS. Univ. 

Cambridge. 

3:00 MMM27 508.11 In vivo magnetic resonance imaging and 

structural correlates of spontaneously high impulsivity in 

rats. D. CAPRIOLI*; S. J. SAWIAK; D. E. H. THEOBALD; T. 

CARPENTER; J. W. DALLEY. Univ. of Cambridge. 



4:00 MMM28 508.12 • Amphetamine produces opposites 

effects on motor impulsivity in a response inhibition task with 

predictable and unpredictable delays. A. C. MARACLE; S. J. 

HAYTON; M. C. OLMSTEAD*. Queen’s Univ., Queens Univ. 

1:00 MMM29 508.13 • Role of noradrenaline and prefrontal 

cortex in behavioural inhibition in rats. A. BARI*; D. E. 

THEOBALD; S. A. ELANDS; T. LEUNG; K. OGANYA; F. 

BADRULHISHAM; T. W. ROBBINS. Univ. of Cambridge, 

Behavioural and Clin. Neurosci. Inst. 

2:00 MMM30 508.14 A comparison of the attentional abilities 

of adolescent and adult rats in a test of visual, sustained 

attention with and without distractors. M. C. WASSERMAN*; 

L. A. NEWMAN; J. MCGAUGHY. Univ. of New Hampshire. 

3:00 MMM31 508.15 An assessment of the attentional set- and 

affective shifting of adolescent rats. J. A. MCGAUGHY*; 

R. CAIN; M. C. WASSERMAN; L. A. NEWMAN. Univ. New 

Hampshire. 

4:00 MMM32 508.16 Do differences in noradrenergic and 

cholinergic fiber densities in the prefrontal cortices underlie 

attentional impairments of rats exposed to prenatal protein 

malnutrition? J. R. GALLER*; M. C. WASSERMAN; J. 

BARAIOLO; A. T. BATES; J. MCGAUGHY. Judge Baker 

Children’s Ctr., Univ. of New Hampshire, Univ. of New 

England. 

1:00 MMM33 508.17 Selective dopamine reuptake inhibitors 

improve prefrontal-dependent function and elevate 

norepinephrine and dopamine levels within the prefrontal 

cortex: Relevance to ADHD. B. E. SCHMEICHEL*; C. W. 

BERRIDGE. Univ. of WI-Madison. 

2:00 MMM34 508.18 Cue-dependent changes to membrane 

excitability in the medial prefrontal cortex following training in 

operant or response inhibition tasks. S. J. HAYTON*; M. C. 

OLMSTEAD; E. C. DUMONT. Queen’s Univ. 

3:00 MMM35 508.19 Alterations in norepinephrine, dopamine 

and serotonin in the medial prefrontal cortex of adult rats 

exposed to prenatal protein malnutrition. D. J. MOKLER*, 

Ph.D.; D. C. BASS; P. J. MORGANE; J. R. GALLER. Univ. 

New England, Judge Baker Children’s Center, Harvard Med. 

Sch. 

4:00 MMM36 508.20 Regulation of risk-based decision making 

by dopamine D1 and D2 receptors in the nucleus accumbens. 

C. M. STOPPER*; S. KHAYAMBASHI; D. KELLY; S. B. 

FLORESCO. Univ. British Columbia. 

1:00 MMM37 508.21 Testosterone modulates risk-based 

decision making in male rodents. S. R. WAINWRIGHT*; J. 

R. ST. ONGE; S. B. FLORESCO; L. A. M. GALEA. Univ. of 


2:00 MMM38 508.22 Functional disconnection of prefrontalamygdala-striatal 

circuitry alters risk-based decision making. 

J. R. ST.ONGE*; S. B. FLORESCO. Univ. British Columbia. 

3:00 MMM39 508.23 � Dissociable contribution of D1 and D2 

receptors in the medial prefrontal cortex to risk-based decision 

making. H. ABHARI*; J. R. ST. ONGE; S. B. FLORESCO. 

Univ. of British Columbia, Univ. British Columbia. 

4:00 MMM40 508.24 Fundamental contribution of phasic 

dopamine activity to decision making about reward magnitude. 

S. B. FLORESCO*; A. BLAIR; J. R. ST. ONGE. Univ. British 

Columbia. 

1:00 MMM41 508.25 Acute stress perturbs different forms of 

cost-benefit decision making. N. SHAFIEI*; S. B. FLORESCO. 



Mon. PM

POSTER 

509. Learning and Memory Systems: Genetic and 

Pharmacological Manipulation 



1:00 MMM42 509.1 GluN10XX (NR1-a) splice variant of 

the NMDA receptor is more important for spatial reference 

memory than working memory in mice. S. R. DAS*; R. 

KELSAY; K. R. MAGNUSSON. Oregon State Univ. 

2:00 MMM43 509.2 In utero exposure to cigarette smoking 

causes decreased anxiety in a mouse model. R. M. AMOS- 

KROOHS*; A. A. BRAUN; C. L. WEBB; T. S. BIRTLES; R. M. 

GREENE; M. M. PISANO; M. T. WILLIAMS; C. V. VORHEES. 

Cincinnati Children’s Hosp. Med. Ctr., Univ. of Louisville. 

3:00 MMM44 509.3 Anti-Nogo-A immunotherapy improves the 

organization of exploratory behavior following fimbria-fornix 

lesions in adult rats. K. M. PODRAZA*; J. R. KÖPPEN; S. S. 

WINTER; S. TSAI; D. G. WALLACE; G. L. KARTJE. Neurosci. 

Program, Loyola Univ. Chicago, Res. Service, Hines VA 

Hosp., Northern Illinois Univ. 

4:00 MMM45 509.4 Bdnf and escape from social aggression 

in hamsters. D. H. ARENDT*; J. P. SMITH; C. C. BASTIDA; 

M. PRASAD; T. L. RASMUSSEN; K. D. OLIVER; R. 

E. CARPENTER; K. M. EYSTER; T. R. SUMMERS; Y. 

DELVILLE; C. H. SUMMERS. Univ. South Dakota, Univ. of 

Texas, Emerson Col., Stanford Univ. 

1:00 MMM46 509.5 Asymmetrical activation of the immediate 

early gene Arc in the prefrontal cortex in young mice 

and recruitment of the opposite hemisphere in old. K. R. 

MAGNUSSON*; D. ZAMZOW; K. ZITTEL; Y. CAMPBELL; R. 

JENSEN. Oregon State Univ. 

2:00 MMM47 509.6 • The effects of twelve weeks of sucrose 

feeding on spatial learning and memory and brain-derived 

neurotrophic factor in young female rats. N. A. JURDAK*; R. 

B. KANAREK*; K. E. D’ANCI; M. RIOS; G. A. CALDERON. 

Tufts Universtiy, Tufts Univ. 

3:00 MMM48 509.7 Systemic injection of cisplatin impairs 

cognitive functions in rats. H. MENG*; C. GUO; N. GRACIAS; 

N. LIU; X. XU; M. R. KELLEY; M. R. VASKO. Indiana Univ. 

Sch. Med. 

4:00 MMM49 509.8 Learning/memory impairment and 

reduced expression of the HNK-1 carbohydrate in β-1,4- 

Galactosyltransferase-2-deficient mice. T. YOSHIHARA*; 

K. SUGIHARA; Y. KIZUKA; S. OKA; M. ASANO. Kanazawa 

Univ., Kyoto Univ. 

1:00 MMM50 509.9 • Learning and memory impairments in 

interleukin-1 receptor 1 null mutant mice are sex-dependent. 

J. A. JOHNSON*; S. N. RESCH; A. PEREZ; C. NAVAS; F. 

ROTELLA; S. SHARMA; B. SALZMAN; S. D. CROLL. CUNY 

- Queens College/Graduate Ctr., Queens Col., Regeneron 

Pharmaceuticals. 

2:00 MMM51 509.10 Inhibition of MARCKS phosphorylation 

improves working memory. A. N. ALLEN; J. S. TALBOOM; H. 

A. BIMONTE-NELSON; N. S. BROUGHTON; N. J. HACKETT; 

M. R. SCHELDRUP; E. B. ENGLER-CHIURAZZI; K. R. 

VANKEUREN-JENSEN*; M. J. HUENTELMAN. TGen, The 

Arizona Alzheimer’s Consortium, Arizona State Univ. 

3:00 MMM52 509.11 Voluntary consumption of a high calorie 

diet impairs hippocampal-dependent memory in male rats. J. 

DARLING*; A. P. ROSS; T. J. BARTNESS; M. B. PARENT. 

Georgia State Univ. 


4:00 MMM53 509.12 � Genetically inherited aerobic 

capacitance has no significant effect on spatial learning and 

its reversal in the Morris Water maze. M. KUZNIA*; C. M. 

WALSH; S. L. BRITTON; L. G. KOCH; G. R. POE. Univ. of 

Michigan Dept. of Anesthesiol. 

1:00 MMM54 509.13 Altered Morris water maze performance 

and signaled operant responding after single or repeated 

injection of staphylococcal enterotoxin A. R. WOODRUFF*; K. 

M. SCHORPP; A. J. LAWRENCZYK; A. KUSNECOV. Rutgers 

Univ. 

2:00 MMM55 509.14 • Molecular control of decision making 

involving glial cystine-glutamate transporters. E. LANGER*; 

S. SHIPPY; M. RAGOZZINO; T. PARK; D. FEATHERSTONE. 

Univ. of Illinois Chicago. 

3:00 MMM56 509.15 Levothyroxine supplementation 

to attenuate neurobehavioral effects of exposure to 

polybrominated diphenyl ethers in rats. L. L. DRISCOLL*; M. 

FRANCO; A. RHOADS; M. SEAY. Colorado Col. 

4:00 MMM57 509.16 Involvement of dynamin1, a synaptic 

endocytosis modulator , in the ameliorative effect of 

Yokukansan on memory disturbances in an animal model of 

Alzheimer’s disease. Y. SAKATA*; K. IWASAKI; K. TAKASAKI; 

A. NOGAMI; N. UCHIDA; S. TASHIRO; M. TANAKA; T. 

SHINDO; K. KUBOTA; S. KATURABAYASHI; K. MISHIMA; R. 

NISHIMURA; M. FUJIWARA. Fac. of Pharmaceut. Sciences, 

Fukuoka Univ., Sch. of Medicine, Fukuoka Univ. 

1:00 MMM58 509.17 Neuroprotective effect of Krill 

phosphatidylserine on trimethyltin-induced learning and 

memory deficits in the rat. H. PARK*; H. SHIM; K. KIM; M. 

LEE; H. SONG; J. HAN; D. HAHM; H. LEE; I. SHIM*. The 

Catholic Med. Sch., Korea Basic Sci. Inst., Doosan Corp., 

Kyung Hee Univ. 

2:00 MMM59 509.18 Auditory discrimination learning in Arc/ 

Arg3.1 knockout mice. C. MAHLKE*; F. THEDEN; S. MICELI; 

D. KUHL. Universitätsklinikum Hamburg-Eppendorf (UKE). 

3:00 MMM60 509.19 • In vitro and in vivo evaluation of 

quinolone carboxylic acid-derived selective M 1 receptor 

positive allosteric modulators. D. C. BESHORE*; R. M. 

DIPARDO; R. K. CHANG; C. N. DI MARCO; D. R. PITTS; 

W. J. RAY; L. MA; M. WITTMANN; M. A. SEAGER; K. A. 

KOEPLINGER; C. D. THOMPSON; G. D. HARTMAN; M. T. 

BILODEAU; S. D. KUDUK. Merck & Co., Inc. 

4:00 MMM61 509.20 Long-lasting behavioral and molecular 

effects induced by chronic mild stress and by antidepressants 

treatment. L. PINTO*; J. BESSA; A. PINHEIRO; M. MORAIS; 

S. MONTEIRO; N. SOUSA. Life and Hlth. Sci. Res. Inst. - 

Sch. of Hlth. Sci. - UM. 

1:00 MMM62 509.21 Assessment of working memory, anxiety 

and depression in iron deficient rats. P. VIEYRA-REYES; 

R. DRUCKER-COLIN*; G. OTERO-OJEDA; B. PLIEGO- 

RIVERO. Univ. Autonoma del Estado de Mexico, Insituto de 

Fisiologia Celular, UNAM. 

2:00 MMM63 509.22 Role of neuroinflammation in 

methamphetamine induced deficits in learning and memory. 

C. J. WILHELM; M. S. HUCKANS; J. M. LOFTIS*. Oregon 

Hlth. Sci. Univ., Portland Veterans Affairs Med. Ctr. 

3:00 MMM64 509.23 Inhibition of phosphodiesterase-4 reverses 

memory deficits produced by Abeta1-40 and 25-35 peptides 

in rats. C. WANG*; Y. CHENG; Y. LI; Y. HUANG; J. XU; H. 

ZHANG. WVU Hlth. Sci. Ctr., Sch. of Pharmaceut. Sciences, 

Southern Med. Univ. 



4:00 MMM65 509.24 Facilitation in hippocampal neurogenesis 

in young rats fed theanine, an amino acid in tea leaves, 

and its effect on cognitive function. K. T SAKAMOTO*; 

A. TAKEDA; H. TAMANO; N. INUI; S. SUH; S. WON; H. 

YOKOGOSHI. Univ. of Shizuoka, Univ. of California, Dept. of 

Physiol. 

1:00 MMM66 509.25 Effects of 56Fe irradiation and alpha lipoic 

acid on spatial memory retention of apoe2 and apoe4 female 

mice in the water maze. L. E. VILLASANA*; J. RABER. 

Oregon Hlth. & Sci. Univ., Neurol., Div. of Neuroscience, 

ONPRC. 

2:00 MMM67 509.26 Time-dependent effect of systemic LPS 

administration on spatial memory retrieval and reversal 

learning. G. LEWANDOWSKI*; T. MIYASHITA; A. VOGEL- 

CIERNIA; J. GUZOWSKI. Univ. California, Irvine. 

3:00 MMM68 509.27 Cumulative benefits of transcranial direct 

current stimulation of the prefrontal cortex paired with training 

on spatial learning and memory performance in rats. C. 

DOCKERY*; D. LIEBETANZ; M. WESIERSKA. Instit Med. 

Psycholog, Univ. Med. Ctr. Goettingen, Polish Acad. of Sci. 

4:00 MMM69 509.28 Targeted mutation in the Na,K-ATPase 

alpha 2 isoform confers ouabain resistance and results in 

altered learning, acoustic startle, and locomotor behavior 

following a methamphetamine challenge. T. L. SCHAEFER*; 

J. B. LINGREL; A. E. MOSELEY; C. V. VORHEES; M. T. 

WILLIAMS. Children’s Hosp Resch Fndtn, Univ. of Cincinnati 

Col. of Med., Monsanto Co. 

POSTER 

510. Memory Consolidation and Reconsolidation: Behavior 



1:00 MMM70 510.1 The role of the dorsal hippocampus in 

appetitive renewal of magazine approach using physical 

and temporal contexts. V. CAMPESE*; A. R. DELAMATER. 

Brooklyn Coll CUNY. 

2:00 MMM71 510.2 Retrieval of stressful memories in rodents: 

Insight into therapeutic applications of treatment for PTSD. 

M. A. REILLY; D. BISSELL; K. D. LAWLER; C. FRICANO; M. 

RICCIARDI; A. J. BETZ*. Quinnipiac Univ. 

3:00 MMM72 510.3 Effects of predictable vs. un-predictable 

aversive learning early in development on adult fear 

conditioning. D. SEO*; M. H. MONFILS. The Univ. of Texas At 

Austin. 

4:00 MMM73 510.4 Extinction during reconsolidation window 

prevents return of conditioned responses in Pavlovian 

appetitive learning. M. E. THOMPSON; D. J. POWELL; M. H. 

MONFILS; H. J. LEE*. Univ. Texas, Austin. 

1:00 MMM74 510.5 Facilitation of an aversive task by a 

none aversive one: What it depends on? M. SNITCOFSKY*; 

N. C. COLETTIS; C. J. BLANCO; E. KORNISIUK; D. A. 

JERUSALINSKY. IBCN, Med. Sch., Vet. School, UBA. 

2:00 NNN1 510.6 � Retrieval of a consolidated appetitive 

memory allows updating with a novel aversive stimulus. B. 

SONG; M. E. THOMPSON; C. E. JONES; H. J. LEE; M. H. 

MONFILS*. Univ. of Texas At Austin. 

3:00 NNN2 510.7 Temporally-graded retrograde amnesia 

(TGRA) for unreinforced, non-navigational spatial information 

in rats with continuous inactivation of the hippocampus. S. 

GASKIN*; M. TARDIF; D. MUMBY. Concordia Univ. 



4:00 NNN3 510.8 � Effects of chronic low doses of caffeine 

and taurine on fear expression: Insight into the emergence of 

PTSD. K. LAWLER*; M. A. REILLY; D. BISSELL; A. J. BETZ. 

Quinnipiac Univ. 

1:00 NNN4 510.9 Post-training cannabinoid administration 

impairs 24-hour consolidation of rodent spatial memory. F. T. 

CANDELARIA-COOK*; D. A. HAMILTON. Univ. New Mexico. 

2:00 NNN5 510.10 The effects of aging on spatial memory 

reconsolidation in rats. B. J. JONES*; E. BUKOSKI; L. 

NADEL; J. FELLOUS. Univ. Arizona. 

3:00 NNN6 510.11 Working and reference memory across the 

estrous cycle in gonadally intact female rats: Role of estrogen. 

A. POMPILI; C. TOMAZ; B. ARNONE; C. TAVARES; A. 

GASBARRI*. Univ. of L’Aquila, Univ. Brasilia, Univ. L’Aquila. 

4:00 NNN7 510.12 Behavioral interference during 

reconsolidation reduces expression of complex fear 

memories. C. E. JONES*; M. H. MONFILS. The Univ. of 

Texas. 

1:00 NNN8 510.13 Memory consolidation of auditory 

discrimination learning in starlings: Exploring the effects of 

auditory interference across waking and sleep. T. P. BRAWN*; 

H. C. NUSBAUM; D. MARGOLIASH. Univ. of Chicago. 

2:00 NNN9 510.14 Dorsolateral entorhinal cortex damage 

spares performance on two spatial memory tasks. N. 

GERVAIS*; S. GASKIN; C. DI GIANDOMENICO; D. G. 

MUMBY. Concordia Univ. 

3:00 NNN10 510.15 The involvement of extinction and the 

reduction of the strong training constraint on reconsolidation. 

G. E. ARCHBOLD*; K. NADER. McGill Univ. 

4:00 NNN11 510.16 Nothing like the first time? Different 

memory acquisition mechanisms for similar events. P. S. 

FINNIE*; K. NADER. McGill Univ. 

1:00 NNN12 510.17 Cellular and systems consolidation and 

reconsolidation of recent and remote contextual fear memory 

in the anterior cingulate cortex. E. O. EINARSSON*; K. 

NADER. McGill Univ. 

2:00 NNN13 510.18 Impaired long term depression enhances 

latent inhibition. C. LAPISH*; D. M. ASHBY; C. M. DIAS; J. 

G. HOWLAND; Y. T. WANG; A. G. PHILLIPS. Univ. of British 

Columbia, Univ. of Saskatchewan. 

POSTER 

511. Reward: Neurocircuitry 



1:00 NNN14 511.1 Nucleus accumbens shell AMPA receptors 

mediate extinction of reward seeking. Z. MILLAN*; G. P. 

MCNALLY. Univ. of New South Wales. 

2:00 NNN15 511.2 Limbic-pallidal mechanisms for marijuana 

and hunger to make food taste good: Endocannabinoid, 

orexin and neurotensin ‘liking’ hotspots in the posterior ventral 

pallidum. C. HO*; P. HSIEH; K. BERRIDGE. Univ. Michigan. 

3:00 NNN16 511.3 Separate encoding of reward expectation 

and social ranking in the primate caudate nucleus. G. S. 

SANTOS*; Y. NAGASAKA; N. FUJII; H. NAKAHARA. RIKEN 

BSI, Tokyo Inst. of Technol. 

4:00 NNN17 511.4 Influence of internal state on the coding of 

natural rewards in the central amygdala and insular cortex. B. 

F. SADACCA*; D. B. KATZ. Brandeis Univ. 


Mon. PM

1:00 NNN18 511.5 Locally distributed coding of reward value 

in human orbitofrontal cortex. T. KAHNT*; J. HEINZLE; S. 

Q. PARK; J. HAYNES. BCCN Berlin, Freie Univ. Berlin, Max 

Planck Inst. for Human Cognitive and Brain Sci. 

2:00 NNN19 511.6 Activity of neurons in the thalamic 

centromedian nucleus during behavioral tasks with reward 

bias and re-bias. K. YAMANAKA*; Y. HORI; Y. UEDA; T. 

MINAMIMOTO; M. KIMURA. Tamagawa Univ. Brain Sci. Inst., 

Kyoto Prefectural Univ. of Med., Natl. Inst. of Radiological Sci. 

3:00 NNN20 511.7 Singing-related neurons of the anterior 

forebrain pathway are activated in response to food rewards in 

songbirds. Y. SEKI*; K. XIE; N. A. HESSLER; K. OKANOYA. 

RIKEN BSI, Harvard Univ. 

4:00 NNN21 511.8 Basolateral amygdala inactivation reduces 

sexual motivation during a T-maze task with sexual reward 

in male rats. M. HERNANDEZ*; F. ROBLES-AGUIRRE; G. 

QUIRARTE; M. GUEVARA; P. HARO. Univ. de Guadalajara, 

Inst. Nacional de Neurología y Neurocirugía, Inst. de 

Neurobiología UNAM. 

1:00 NNN22 511.9 The dorsal striatum in processing of 

monetary reward in cocaine addiction: An fMRI-VBM study. A. 

B. KONOVA*; M. A. PARVAZ; N. ALIA-KLEIN; T. MALONEY; 

P. A. WOICIK; D. TOMASI; R. WANG; F. TELANG; G. 

WANG; N. D. VOLKOW; R. GOLDSTEIN. Brookhaven Natl. 

Lab., Stony Brook Univ., Natl. Inst. on Alcohol Abuse and 

Alcoholism, Natl. Inst. on Drug Abuse. 

2:00 NNN23 511.10 The representation of a “meal” and “meal 

size” is encoded by nucleus accumbens neurons. L. A. 

TELLEZ*; S. A. SIMON; R. GUTIERREZ. CINVESTAV, Duke 

Univ. 

3:00 NNN24 511.11 Irrational reward contingency in the 

competitive video game suppresses outcome-related 

prefrontal neuronal activity in the monkey. T. HOSOKAWA*; 

M. WATANABE. Tokyo Metropolitan Inst. for Neurosci. 

4:00 NNN25 511.12 • A thalamocortical circuit for learning 

reward-guided actions. C. YU*; D. FAN; H. YIN. Duke Univ. 

1:00 NNN26 511.13 Lack of potentiated accumbal encoding of 

reward following acute endocannabinoid uptake blockade. E. 

B. OLESON*; M. V. BECKERT; D. LEBESGUE; J. F. CHEER. 

Univ. of Maryland Sch. Med., Albert Einstein Col. of Med. 

2:00 NNN27 511.14 Reference-dependent utility is encoded 

in orbitofrontal cortex. B. BUSHONG*; M. RABIN; C. F. 

CAMERER; A. RANGEL. Caltech, Univ. of California - 

Berkeley. 

3:00 NNN28 511.15 Food pleasantness and self-control are 

related to activity in a region of the lateral orbitofrontal cortex 

underlying inferences about food reward. W. K. SIMMONS; 

S. J. KALLMAN; L. A. MILBURY; J. E. INGEHOLM*; N. D. 

KNUTH; K. D. HALL; A. MARTIN. Laureate Inst. for Brain 

Res., NIMH / NIH, NIDDK / NIH. 

4:00 NNN29 511.16 Overlapping but uniquely distributed 

decision values for different goods within the human 

ventromedial prefrontal cortex. D. MCNAMEE*; A. RANGEL; 

J. O’DOHERTY. Trinity Col. Inst. of Neurosci., Caltech. 

1:00 NNN30 511.17 • Lateral habenula nucleus connectivity 

in the primate. J. LEHMAN*; R. MATHESON; S. N. HABER. 

Univ. of Rochester Sch. of Med. and Dent. 

2:00 NNN31 511.18 Positive and negative reward value coding 

in the primate lateral hypothalamus. A. NORITAKE*; K. 

NAKAMURA. Kansai Med. Univ., ATR, PRESTO. 


3:00 NNN32 511.19 The role of the hippocampus-ventral 

tegmental area connection in methamphetamine (meth)- 

induced reinforcement learning. Y. B. KELETA*; A. SIKORSKI; 

J. L. MARTINEZ. Univ. Texas at San Ant, Texas A & M Univ. at 

Texarkana. 

4:00 NNN33 511.20 A role for nucleus accumbens betaendorphin 

in the incubation of cocaine craving. Y. DIKSHTEIN*; 

N. KRONFELD; R. BARNEA; I. GISPAN; G. YADID. The 

Mina&Evarerd Fac. of Life Sciences, Bar-Ilan Univ. 

1:00 NNN34 511.21 Habenula stimulation alters the attribution 

of incentive salience to a reward predictive cue. C. L. DANNA; 

P. D. SHEPARD; G. I. ELMER*. Maryland Psychiatric Res. 

Center, Univ. of Maryland, Maryland Psychiatric Res. Ctr. 

2:00 NNN35 511.22 Identification of lateral habenular neurons 

relaying hypothalamic input to monoaminergic hindbrain 

circuits. W. C. POLLER; R. BERNARD*; V. I. MADAI; T. 

KAHL; G. LAUBE; R. W. VEH. Charite Berlin. 

3:00 NNN36 511.23 Proximity to a goal influences the 

encoding of reward-predictive cues in nucleus accumbens 

neurons. V. B. MCGINTY*; S. LARDEUX; J. DU HOFFMANN; 

S. M. NICOLA. Albert Einstein Col. Med. 

4:00 NNN37 511.24 The role of experience in modulating 

neurochemical and cellular markers of nucleus accumbens 

neuron activity: Food intake and food-reinforced behaviors. 

K. N. SEGOVIA*; M. CORREA; J. SALAMONE. Univ. of 

Connecticut. 

1:00 NNN38 511.25 • Viral-mediated expression of Narp in the 

medial prefrontal cortex rescues morphine conditioned place 

preference in the Narp KO mouse. A. M. BLOUIN*; S. HAN; 

A. M. PEARCE; K. CHENG; A. W. JOHNSON; M. J. DURING; 

P. C. HOLLAND; J. M. BARABAN; I. M. RETI. Johns Hopkins 

Univ., Ohio State Univ. 

2:00 NNN39 511.26 Neural processing of appetitive and 

aversive stimuli in the primate dorsal raphe nucleus. K. 

HAYASHI*; K. NAKAO; K. OKADA; Y. KOBAYASHI; K. 

NAKAMURA. Kansai Med. Univ., Osaka Univ., PRESTO, JST. 

3:00 NNN40 511.27 The motivational control of performance is 

supported by habenula and amygdala synergy within a limbic 

network. J. A. GRIEGO*; L. M. ROWLAND; H. H. HOLCOMB. 

Univ. of Osnabrueck, Univ. Maryland Med. Sch. 

4:00 NNN41 511.28 The primate amygdala reflects competition 

between different outcomes while the basal forebrain encodes 

vigilance. C. J. PECK*; C. D. SALZMAN. Columbia Univ. 

1:00 NNN42 511.29 Role of neurons in the monkey ventral 

pallidum in the detection of unpredictable rewarding stimuli. S. P. 

RAVEL*; P. APICELLA; S. NOUGARET; E. LEGALLET. CNRS. 

2:00 NNN43 511.30 Ultrastructural analysis of the projection 

from the lateral hypothalamic area to the lateral habenula 

in the rat. J. BALCITA-PEDICINO; S. R. SESACK*. Univ. 

Pittsburgh. 

POSTER 

512. Motivation and Emotion: Neuropharmacology of Decision 

Making 



1:00 NNN44 512.1 The roles of nicotinic and muscarinic 

cholinergic receptors in cost-benefit decision making. I. A. 

MENDEZ*; J. DAMBORSKY; J. L. BIZON; U. WINZER- 

SERHAN; B. SETLOW. Texas A&M Univ., Texas A&M Univ. 

Hlth. Sci. Ctr. 



2:00 NNN45 512.2 Acute administration of drugs of abuse 

modulates risky decision making. M. R. MITCHELL*; C. M. 

VOKES; A. L. BLANKENSHIP; N. W. SIMON; B. SETLOW. 

Texas A&M Univ. 

3:00 NNN46 512.3 D2 dopamine receptor expression predicts 

distinct forms of impulsivity in rats. B. SETLOW*; N. W. 

SIMON; B. S. BEAS; K. S. MONTGOMERY; R. J. GILBERT; 

M. R. MITCHELL; R. P. HABERMAN; J. L. BIZON. Texas 

A&M Univ., Univ. of Florida, Univ. of Pittsburgh, Johns Hopkins 

Univ. 

4:00 NNN47 512.4 Dopamine receptor modulation of risky 

decision-making. N. W. SIMON*; K. S. MONTGOMERY; B. 

S. BEAS; C. L. LASARGE; R. P. HABERMAN; J. L. BIZON; 

B. SETLOW. Univ. of Pittsburgh, Texas A&M Univ., Johns 

Hopkins Univ., Univ. of Florida. 

1:00 NNN48 512.5 Genetic influences on decision-making 

under risk in rats: Involvement of monoamine transmitters. J. 

R. ASHENHURST*; J. A. WOODS; J. D. JENTSCH. UCLA. 

2:00 NNN49 512.6 Characterization of approach and 

avoidance components of reversal learning performance 

in rodents using a 3-choice visual discrimination in a 

touchscreen-based apparatus. A. S. JAMES*; E. SEU; J. D. 

JENTSCH. UCLA. 

3:00 NNN50 512.7 Dopamine modulation and activity 

dependent synaptic plasticity in cortico-basal ganglia circuit as 

a neuronal mechanism of decision optimization in a reaction 

time task. P. HSIAO*; C. LO. Natl. Tsing Hua Univ. 

4:00 OOO1 512.8 Dynamic tuning of perceptual decision 

making in a cortical circuit model by top-down excitation and 

inhibition inputs. C. LO*; C. WANG. Natl. Tsing Hua Univ. 

1:00 OOO2 512.9 A neuroscientist and an economist 

walk into a bar⋯. D. BURGHART*; S. C. LAZZARO; P. W. 

GLIMCHER. New York Univ. 

2:00 OOO3 512.10 Effects of serotonin depletion on effortful 

decision making and pavlovian autoshaping in rats. A. 

IZQUIERDO*; A. MCCALL-CRADDOLPH; J. CHEN; S. 

CHEUNG; G. YAGNIK; F. ZHOU. California State Univ, Los 

Angeles. 

3:00 OOO4 512.11 Changes in response control and 

prefrontal dopaminergic system across adolescence. F. 

NANEIX*; A. R. MARCHAND; G. DI SCALA; J. PAPE; 

E. COUTUREAU. CNIC UMR 5228 CNRS/Université de 

Bordeaux. 

4:00 OOO5 512.12 Limbic striatum and amygdala play 

dissociable roles in decision-making about risk in rats. E. 

SEU*; J. D. JENTSCH. UCLA. 

POSTER 

513. Neuroethology: Social Behavior, Aggression, and Arousal 



1:00 OOO6 513.1 Muscarinic activation regulates 

developmental and experience-dependent structural 

plasticity of honey bee Kenyon cells. S. E. DOBRIN*; G. E. 

ROBINSON; S. E. FAHRBACH. Wake Forest Univ. Sch. Med., 

Univ. of Illinois at Urbana-Champaign. 

2:00 OOO7 513.2 Developmental hormone signals regulate 

neuronal morphology in adult worker honey bees. R. A. 

VELARDE; D. E. WILSON; S. E. FAHRBACH*. Wake Forest 

Univ. 



3:00 OOO8 513.3 Differences in brain miRNA expression 

are associated with honey bee behavioral maturation. J. 

GREENBERG; S. THATCHER; S. AMENT; T. NEWMAN; P. 

GREEN; G. ROBINSON; Y. BEN-SHAHAR*. Washington 

Univ., Delaware Biotech. Inst., Univ. of Illinois Urbana- 

Champaign. 

4:00 OOO9 513.4 Arousal states: Investigating the moltsleep 

in insects. D. MACWILLIAM*; M. E. ADAMS. Univ. of 

California, Riverside. 

1:00 OOO10 513.5 Thermal microenvironments within the 

litter huddle during early development are associated with 

individual differences in behavior and physiology in rabbits. V. 

REYES*; L. NICOLAS; M. MARTINEZ-GOMEZ; R. HUDSON; 

A. BAUTISTA. Univ. Veracruzana, Univ. Autonoma de 

Tlaxcala, Univ. Nacional Autonoma de Mexico. 

2:00 OOO11 513.6 Neural adaptations for imitation: 

Diffusion tensor imaging of the mirror system in macaques, 

chimpanzees, and humans. E. E. HECHT*; D. A. GUTMAN; T. 

M. PREUSS; L. A. PARR; J. K. RILLING. Yerkes Natl. Primate 

Res. Ctr., Emory Univ. 

3:00 OOO12 513.7 The lonely worm: Isolated versus group 

housed planarians. M. J. SAARI*; P. DELUCA; J. VAN ROOIJ; 

A. STILLAR. Nipissing Univ. 

4:00 OOO13 513.8 Effects of social experience on place 

preference conditioning to morphine in juvenile mice. B. 

KENNEDY*; J. B. PANKSEPP; G. P. LAHVIS. OHSU. 

1:00 OOO14 513.9 The involvement of CRF receptor 

type 2 in social behavior. Y. SHEMESH*; A. NEUFELD; E. 

SCHNEIDMAN; A. CHEN. Weizmann Inst. of Sci. 

2:00 OOO15 513.10 The effects of arginine vasotocin 

administration on social behavior in the green anole lizard 

(Anolis carolinensis). L. A. DUNHAM*; W. WILCZYNSKI. 

Georgia State University, Neurosci. Inst., Ctr. for Behavioral 

Neurosci. 

3:00 OOO16 513.11 Pheromonal and behavioral cues trigger 

male aggression in Drosophila. M. FERNANDEZ*; Y. CHAN; 

J. Y. YEW; J. BILLETER; K. DREISEWERD; J. D. LEVINE; 

E. A. KRAVITZ. Harvard Med. Sch., Temasek Life Sci. Labs., 

Univ. of Toronto, Westfälische Wilhelms-Universität Münster. 

4:00 OOO17 513.12 Familiarity confers transient social 

benefits among groups of crayfish. B. L. ANTONSEN*; L. E. 

MITCHELL. Marshall Univ. 

1:00 OOO18 513.13 Characterization of housing-type social 

buffering in male rats. Y. KODAMA*; Y. KIYOKAWA; Y. 

TAKEUCHI; Y. MORI. Univ. of Tokyo. 

2:00 OOO19 513.14 Motor maturation and social development 

in naked mole-rats. C. M. COMER*; Y. BABA. The Univ. of 

Montana. 

3:00 OOO20 513.15 Social instigation, 5-HT1A receptors, 

aggressive behavior and pre-frontal cortex in male mice. R. 

M. DE ALMEIDA*; D. J. STEIN; A. B. LUCION; K. A. MICZEK. 

UFRGS, Tufts Univ. 


Mon. PM

POSTER 

514. Novel Biochemical Techniques 



1:00 OOO21 514.1 Reconstitution of the dopamine transporter 

homologue, LeuT into nanodiscs for structural studies using 

small angle X-ray scattering (SAXS). N. CHEROUATI; L. 

ARLETH; C. LØLAND; U. GETHER*. Panum Inst. Univ. 

Copenhagen, Univ. of Copenhagen, Fac. of Life Sci. 

2:00 OOO22 514.2 Preparation of cell derived membrane 

vesicles with therapeutic potential. A. KITTEL*; B. GYÖRGY; 

D. BONCZ; K. PÁLÓCZY; P. MISJÁK; E. I. BUZÁS. IEM HAS, 

Semmelweis Med. Sch. 

3:00 OOO23 514.3 • Using stable isotopes, in vivo microdialysis 

and mass spectrometry to monitor large neutral amino acid 

levels in the brain. R. BONGIOVANNI; J. A. GARSED; G. E. 

JASKIW*. Louis Stokes Cleveland VAMC, Cleveland State Univ. 

4:00 OOO24 514.4 Detection of oxidized protein-disulfide 

isomerase with a specific antibody. T. UEHARA*. Okayama Univ. 

1:00 OOO25 514.5 • Development and validation of a panel of 

synaptic protein ELISAs. K. E. MCCORMICK*; T. LANZ; C. 

PILSMAKER; L. H. KIMMEL; R. DURHAM; G. A. KARAM; R. 

J. KLEIMAN. Pfizer, Gyros. 

2:00 OOO26 514.6 Detecting modifications of DNA, lipids, 

and proteins due to oxidative stress using immunochemical 

analysis. N. SRIVASTAVA; F. AHMADI; K. LONG; M. KUNIS; 

W. A. SPECKMANN*. Millipore. 

3:00 OOO27 514.7 Adenosine modulation of the blood brain 

barrier. A. CARMAN*; J. H. MILLS; M. S. BYNOE. Cornell 

University, Col. of Vet. Med., Cornell University, Col. of Vet. Med. 

4:00 OOO28 514.8 • Neuronal signaling analysis by 

reverse-phase protein arrays (RPA). F. G. REVEL*; S. 

OBERMUELLER; P. PIRAINO; J. LAMERZ; T. SCHINDLER; 

H. LANGEN; C. FATTINGER; J. G. WETTSTEIN; M. C. 

HOENER; G. DERNICK; G. WALKER. F. Hoffmann-La 

Roche, Paolo Piraino Statistical Consulting. 

1:00 OOO29 514.9 Further improvement of the SymDAQ 

derivatization method for single-run profiling of monoamines 

and amino acids in various matrices by LC-MS/MS. M. G. DE 

VRIES*; T. KLEIN; C. HOFLAND; G. FLIK; E. DREMENCOV; 

T. I. F. H. CREMERS. Univ. of Groningen, Brains On-Line BV, 

Brains On-Line US LLC. 

2:00 OOO30 514.10 Simultaneous high resolution quantitation 

of behavior and dopamine release transients in freely moving 

rats. G. L. OSTERHAUS*; T. COFFEY; A. N. ORTIZ; P. 

SELLEY; S. C. FOWLER; M. A. JOHNSON. Univ. Kansas. 

3:00 OOO31 514.11 • Secreted APP and amyloid β 

quantification in SH-SY5Y cell media using high sensitivity 

immunoassay. A. ATKINSON; S. ANANI; A. MARCIL; P. 

ROBY; S. PARENT; S. DAHAN; F. LIPARI*. PerkinElmer, 

Perkinelmer Inc. 

4:00 OOO32 514.12 Cell-penetrating peptides target neurons 

with less cell toxicity alone than when conjugated to 

nanoparticles. V. COSTA*; M. K. J. GAGNON; H. ZHANG; Y. 

CHEN; K. W. FERRARA; I. N. PESSAH. UC Davis, UC Davis 

Children’s Ctr. for Envrn. Hlth. and Dis. Prevention, UC Davis 

M.I.N.D. Inst. 

1:00 OOO33 514.13 Simultaneous measurement of subsecond 

dopamine release events and caged compound 

photoactivation in striatal brain slices. M. A. JOHNSON*; 

J. L. FULKS; G. L. OSTERHAUS; K. F. STENSRUD; R. S. 

GIVENS. Univ. Kansas. 


2:00 OOO34 514.14 Validating the role of mGluR4 receptors 

in the physiopathology of anxiety using a selective mGluR4 

positive allosteric modulator. E. LE POUL*; B. CAMPO; 

D. CHARVIN; C. BOLÉA; S. BRUCKNER; M. FONSI; S. 

POLI; M. KALINICHEV; F. GIRARD; S. E. BROWNE; J. 

USLANER; J. F. HESS; K. SMITH; I. J. REYNOLDS. Addex 

Pharmaceuticals, Merck Res. Labs. 

3:00 OOO35 514.15 Peptide-mediated intracellular delivery of 

quantum dots into neurons and glia. K. T. NGUYEN*; S. KIM; 

P. GOYAL; G. A. SILVA. UC San Diego, Mokpo Natl. Univ. 

4:00 OOO36 514.16 Optimization of glutamate-gated 

chloride channels as a tool for neuronal silencing via protein 

engineering. S. J. FRAZIER*; B. N. COHEN; S. KADAMBI; C. 

I. RICHARDS; H. A. LESTER. Caltech. 

1:00 OOO37 514.17 Innovative strategy for maintaining 

activation of the serotonin 2C receptor (5-HT 2C R) 

signalosome. N. C. ANASTASIO; A. G. MCGINNIS; P. 

K. SEITZ*; L. H. L. FINK; C. S. WATSON; F. LAEZZA; A. 

ARGAKOV; A. NATARAJAN; S. R. GILBERTSON; K. A. 

CUNNINGHAM. Univ. Texas Med. Brch, Univ. of Houston, 

Univ. of Nebraska Med. Ctr. 

2:00 OOO38 514.18 Molecular engineering of a photostable, 

monomeric, and photoactivatable fluorescent protein for 

correlative light and electron microscopy. M. PAEZ SEGALA*; 

S. MACKINNEY; S. VISWANATHAN; J. MARVIN; L. L. 

LOOGER. Janelia Farm, HHMI. 

3:00 OOO39 514.19 Biophysics of ligand-gated ion channel 

selectivity: Insights through engineering a cation-selective 

ivermectin sensitive channel for neuronal activation. A. S. 

SADEK*; H. A. LESTER. Caltech. 

POSTER 

515. Advances in Cellular and Molecular Technology I 



1:00 OOO40 515.1 • Antibody-mediated targeted gene transfer 

to nmda nr1 or nr2b subunit-containing neocortical neurons. 

H. CAO; G. ZHANG; A. I. GELLER*. Harvard Med. Sch. 

2:00 OOO41 515.2 Immune reaction to haemagglutinin 

tags expressed by viral vectors. M. L. BROWNLOW*; D. 

MORGAN; M. SELENICA; D. LEE; M. GORDON; K. NASH. 

Univ. of South Florida. 

3:00 OOO42 515.3 • BAC transgenic cell lines for studying 

BDNF gene regulation. K. JAANSON*; M. SEPP; I. KOPPEL; 

T. TIMMUSK. Tallinn Univ. of Technol. 

4:00 OOO43 515.4 Extending the color palette of calcium 

sensing. J. AKERBOOM*; N. CARRERAS; L. TIAN; K. 

SVOBODA; E. R. SCHREITER; L. L. LOOGER. HHMI, Univ. 

of Puerto Rico. 

1:00 OOO44 515.5 Transduction of sub-populations of dorsal 

root ganglion neurons by intrathecal rAAV vectors in rats. 

Q. XU*; B. CHOU; A. MIYANOHARA; C. SANTUCCI; M. P. 

HEFFERAN; M. MARSALA; X. HUA; T. YAKSH. UCSD, Univ. 


2:00 OOO45 515.6 Identification of inhibition-resistant human 

cholinesterase variants through a mammalian functional 

screening system. J. ZHANG; B. WANG; E. RALPH; M. 

MACDONALD; N. BARAKAT; X. ZHENG; J. R. CASHMAN*. 

Human Biomol Res. Inst. 



3:00 OOO46 515.7 Activation of Channelrhodopsin-2 neurons 

using organic LEDs: An in vitro and in vivo validation. L. 

RINCON GONZALEZ*; Y. TUFAIL; S. I. HELMS TILLERY; W. 

J. TYLER. Arizona State Univ. 

4:00 OOO47 515.8 Subcellular analysis of paxillin 

contribution to bradykinin-induced neurite retraction with 

a photoinactivatable paxillin. R. YAMAZAKI*; Y. NIINO; K. 

HOTTA; K. OKA. Keio Univ., RIKEN Brain Sci. Inst. 

1:00 OOO48 515.9 Generation of cortical interneurons 

from mouse embryonic stem cells. Y. J. CHEN*; D. VOGT; 

Y. SASAI; C. NICHOLAS; A. KRIEGSTEIN; A. ALVAREZ- 

BUYLLA; J. RUBENSTEIN. UCSF, RIKEN. 

2:00 OOO49 515.10 CB1 receptor overexpression in distinct 

neuronal subpopulations by virus-mediated gene transfer 

into the hippocampus of adult mice. S. GUGGENHUBER; M. 

KLUGMANN; K. MONORY*; B. LUTZ. Univ. Med. Ctr. of the 

Johannes Gutenberg Univ. 

3:00 OOO50 515.11 Site-directed mutagenesis of calmodulin 

for a quantum dot-FRET sub-cellular calcium sensor. M. C. 

DAVIDSON*; S. J. KIM; G. A. SILVA. Univ. CA, San Diego, 

Mokpo Natl. Univ., UCSD. 

4:00 OOO51 515.12 Axonal differentiation: Using patterned 

substrates to understand neurite determination. D. M. 

YANKER*; J. A. MAURER. Washington Univ. In St. Louis. 

1:00 OOO52 515.13 Highly selective receptor-mediated 

transfection of microglia in vivo. J. M. MALMEVIK*; M. 

ROGERS; M. NILSSON; Y. NAKANISHI; R. A. RUSH; N. R. 

SIMS; H. MUYDERMAN. Flinders Univ., Sahlgrenska Univ. 

Hosp., Kanazawa Univ. 

2:00 OOO53 515.14 Cre driver and responder mice for 

manipulating neuronal activities in a cell-type selective manner. 

L. MADISEN*; T. MAO; S. OH; H. GU; K. SVOBODA; H. ZENG. 

Allen Inst. Brain Sci., HHMI / Janelia Farm Res. Campus. 

3:00 OOO54 515.15 Mannose receptor mediated gene delivery 

into astrocytes. B. HOMKAJORN*; M. ROGERS; R. A. RUSH; 

N. R. SIMS; H. MUYDERMAN. Flinders Univ. 

4:00 OOO55 515.16 • Efficient gene delivery into neural cell 

types. U. LAKSHMIPATHY; R. QUINTANILLA; L. CHASE; C. 

MACARTHUR; Y. LIU; F. BOYCE; D. R. PIPER*; M. RAO. Life 

Technologies, The Scripps Res. Inst., Massachusetts Gen. 

Hosp. 

1:00 OOO56 515.17 Optimizing Gal4/UAS transcriptional 

activation in transgenic zebrafish for habenula-specific genetic 

ablation. C. M. AKITAKE; M. G. GOLL; M. MACURAK; M. E. 

HALPERN*. Carnegie Inst. For Sci. 

2:00 OOO57 515.18 GPCR mediator characterization on 

a label-free platform. E. MASSUDA*; J. KEEFER; S. 

PERSCHKE; H. CHEN. Caliper Life Sci. 

3:00 OOO58 515.19 A chemical-genetic approach for the 

cell type-specific modulation of Gs signaling in vivo. M. S. 

FARRELL*; Y. PEI; J. GUETTIER; J. WESS; B. L. ROTH. 

Univ. of North Carolina Sch. of Med., Natl. Inst. of Diabetes 

and Digestive Kidney Diseases, Natl. Institues of Hlth. 

4:00 OOO59 515.20 • A high expression system for the 

production of recombinant murine protein s. T. ALI*; N. 

CHOW; I. SINGH; B. ZLOKOVIC. Socratech LLC., Univ. of 

Rochester Med. Ctr. 

1:00 OOO60 515.21 Highly efficient retrograde gene transfer 

system by a lentiviral vector pseudotyped with fusion envelope 

glycoprotein for the study of structure and function of neural 

circuit. M. KURAMOCHI*; S. KATO; K. KOBAYASHI; K. 

TAKASUMI; K. KOBAYASHI. Fukushima Med. Univ., Japan 

Sci. and Technol. Cooperation. 



2:00 OOO61 515.22 A new sandwich method for culturing 

dissociated mouse hippocampal neurons. W. CHEN*; C. YUE; 

E. HWANG*. Inst. of Bioinformatics and Systems Biology, 

Natl. Chiao Tung Univ., Dept. of Biol. Sci. and Technology, 

Natl. Chiao Tung Univ. 

3:00 OOO62 515.23 Generation of basal forebrain cholinergic 

neurons from human induced pluripotent stem cells. L. 

DUAN*; C. BISSONNETTE; J. KESSLER. Northwestern Univ. 

4:00 OOO63 515.24 Gene transfer into the brain of the teleost 

fish medaka (Oryzias latipes) using human adenovirus 

and the Cre-loxP system. Y. SUEHIRO*; M. KINOSHITA; 

T. OKUYAMA; A. SHIMADA; K. NARUSE; H. TAKEDA; T. 

KUBO; M. HASHIMOTO; H. TAKEUCHI. Grad. Sch. of Sci. 

Univ. of Tokyo, Kyoto Univ., Natl. Inst. for Basic Biol., Brain 

Sci. Institute, RIKEN. 

1:00 OOO64 515.25 • Comparison of siRNA transfection 

efficiency employing electroporation or lipofection or both in 

rat sympathetic neurons. V. RUIZ-VELASCO; S. MAHMOUD; 

J. K. YUN; G. FEHR; L. A. VOZZA-BROWN*. Penn State Col. 

of Med., Life Technologies. 

2:00 OOO65 515.26 Generation and characterization of 

transplantable induced pluripotent stem cell-derived porcine 

neural precursors. O. KAKINOHANA*; C. CARROMEU; 

J. STRNADEL; D. S. GOLDBERG; R. NAVARRO; C. 

SANTUCCI; J. A. CORLETO; M. P. HEFFERAN; A. J. ACAB; 

A. MUOTRI; M. MARSALA. UCSD, Univ. of California-San 

Diego. 

3:00 OOO66 515.27 Systemic delivery of recombinant adenoassociated 

virus serotypes provides global and stable 

transgene expression in mouse central nervous system. H. 

ZHANG; B. YANG; X. MU; Q. SU; R. HE; S. AHMED; J. XIE; 

M. SENA-ESTEVES; Z. XU*; G. GAO. Univ. Mass Med. Sch. 

4:00 OOO67 515.28 Polyalanine expansion as a pathological 

epitope in oculopharyngeal muscular dystrophy and other 

alanine diseases. S. STOCHMANSKI*; F. BLONDEAU; C. 

GASPAR; P. DION; P. S. MCPHERSON; G. A. ROULEAU. 

Ctr. of Excellence In Neuromics, Univ. De Montréal, Montreal 

Neurolog. Inst. - McGill Univ. 

1:00 OOO68 515.29 Optimization of superovulation and mating 

paradigms for production of transgenic prairie voles (Microtus 

ochrogaster). A. C. KEEBAUGH*; M. E. MOODI; C. E. 

BARRETT; P. P. FERNANDEZ; L. J. YOUNG. Emory Univ. 

2:00 OOO69 515.30 Inducible, subregion and cell-type-specific 

gene knockout in the mouse brain. G. K. DOGBEVIA*; M. 

TREVIÑO; D. ARCOS-DÍAZ; S. FREY; G. KÖHR; P. H. 

SEEBURG; R. SPRENGEL; M. T. HASAN. Max-Planck Inst. 

For Med. Res. 

POSTER 

516. Neuronatomy: Automation, Stereology, and Microscopy 



1:00 OOO70 516.1 Semi-automatic reconstruction of 

retinal ganglion cells using convolutional neural networks. 

U. SÜMBÜL*; S. SONG; K. MCCULLOCH; B. LIN; R. H. 

MASLAND; S. H. SEUNG. MIT, Massachusetts Eye & Ear 

Infirmary, Harvard Med. Sch., The Univ. of Hong Kong. 

2:00 OOO71 516.2 X-ray nanoscope with synapse resolution 

for neuronal circuit reconstruction. H. MIZUTANI*; H. SAGARA; 

T. OHIGASHI; T. TAKAGI. Univ. of Tokyo, Inst. of Med. Science, 

Univ. of Tokyo, Institution:Research Organization of Sci. & 

Engineering, Ritsumeikan Univ., Univ. Tokyo. 


Mon. PM

3:00 OOO72 516.3 • Multiscale imaging, analysis, and 

integration of mouse brain networks. Y. CHOE*; L. C. 

ABBOTT; J. KEYSER; D. E. MILLER; D. HAN; H. YANG; J. R. 

CHUNG; C. SUNG; D. MAYERICH; J. KWON; K. MICHEVA; 

S. J. SMITH. Texas A&M Univ., Univ. of Illinois at Urbana- 

Champaign, Kettering Univ., Stanford Univ. 

4:00 OOO73 516.4 Ultramicroscopy: 3D-reconstruction of 

Drosophila’s inner anatomy. H. DODT*; N. JÄHRLING; C. 

SCHÖNBAUER; F. SCHNORRER; K. BECKER. Tech. Univ. 

Vienna, Med. Univ. Vienna, Univ. Oldenburg, MPI of Biochem. 

1:00 OOO74 516.5 • A comparison of 2d image analysis 

and design-based stereology for evaluating morphological 

changes in the midbrain dopamine system. S. O. AHMAD*; C. 

ALMLI; J. PARK. KUMC: Occup. Therapy Educ., Washington 


2:00 PPP1 516.6 Localisation microscopy using quantum 

dots. O. MANDULA*; C. WILLAMS. Inst. for Adaptive and 

Neural Computation,. 

3:00 PPP2 516.7 Automated cropping and artifact 

removal for Knife-Edge Scanning Microscopy. J. KWON*; D. 

MAYERICH; Y. CHOE. Kettering Univ., Univ. of Illinois, Texas 

A&M Univ. 

4:00 PPP3 516.8 Analysis of three-dimensional structure 

of the zebrafish brain with refraction-enhanced X-ray microtomography. 

T. IKENAGA*; A. NAGATA; T. YAMAMOTO; 

A. TAKEUCHI; K. UESUGI; Y. SUZUKI; K. HATTA. Univ. of 

Hyogo, Japan Synchrotron Radiation Res. Inst. 

1:00 PPP4 516.9 Divide and conquer - Lossless thick 

sectioning of plastic-embedded brain tissue to parallelize 

large volume serial reconstructions. K. J. HAYWORTH*; J. 

C. TAPIA; N. KASTHURI; R. SCHALEK; J. W. LICHTMAN. 

Harvard Univ. 

2:00 PPP5 516.10 Visualization of ultra-small gold particles 

by double-axis tomography after immunogold labeling 

on ultracryo sections of nervous tissue. K. TOHYAMA*; 

K. HANAKI; N. HIRANO; K. ISHIDA; T. HANASAKA; E. 

MATSUURA; K. OGASAWARA; M. MIURA; T. KUBO; T. 

YOTSUJI; T. HASHIMOTO. Iwate Med. Univ., Iwate Univ., 

Hitachi High-Technologies Corp. 

3:00 PPP6 516.11 Quantitative 3-D analysis of dendritic 

spines using geometric models. A. HERZOG*; C. S. 

HERRMANN; U. SEIFFERT; B. MICHAELIS; K. BRAUN. Univ. 

Oldenburg, Fraunhofer IFF, Univ. Magdeburg. 

4:00 PPP7 516.12 The adapted “single-section” Golgi method 

for fish brain. L. M. IDE*; A. BARBOSA JÚNIOR; J. BRUSCO; 

A. HOFFMANN; J. E. MOREIRA. Univ. of São Paulo. 

1:00 PPP8 516.13 Immunocytochemical localization of 

axonally transported WGA-HRP in long term preserved 

neural tissue embedded in Carbowax. C. M. ROSARIO*; P. 

E. MICEVYCH; S. DE LACALLE. Charles Drew Univ. of Med. 

and Sci., UCLA. 

2:00 PPP9 516.14 • Automated analysis of dendritic spine 

density in microscopy images of cortical striatal neurons. 

S. V. ALWORTH*; A. W. DUNAH; J. S. J. LEE. DRVision 

Technologies LLC, Harvard Med. Sch. and Massachusetts 

Gen. Hosp. 

3:00 PPP10 516.15 Development of a laboratory robot for 

automated handling of CNS slice preparations: towards an 

automated high content laser analysis of individual neurons in 

CNS tissue. B. U. KELLER*; E. JABLONSKI; N. GARBOW; 

M. JAISWAL. Univ. Gottingen, Laser Innovation GmbH, Perkin 

Elmer Cell. Technologies GmbH. 


4:00 PPP11 516.16 • A semi-automated, unbiased method 

for neuropathology assessment in full brain images stained 

with fluorojade-b. B. D. ROBERTSON*; F. ROSSETTI; M. 

FURTADO; D. YOURICK. Walter Reed Army Inst. of Res., 

Univ. of North Carolina/North Carolina State Univ. 

1:00 PPP12 516.17 Hapten-based ′virtual pre-embedding 

labeling′: A novel approach for correlative light and electron 

microscopy and for double labeling affinity cytochemistry. V. 

MADAI*; R. BERNARD; W. POLLER; G. LAUBE; R. W. VEH. 

Charité Berlin. 

2:00 PPP13 516.18 • Unbiased cell volume estimations 

in preferentially cut sections with the virtual nucleator. D. 

PERUZZI*; D. HOPPES; P. ANGSTMAN; J. R. GLASER. 

MBF Biosci - MicroBrightField, Inc. 

3:00 PPP14 516.19 • 3D Image acquisition of an entire mouse 

coronal section at high magnification using the Biolucida 

system. S. HENDRICKS*; M. J. FAY; J. O. BLAISDELL; J. H. 

SPRENGER; J. R. GLASER. MBF Biosci. - MicroBrightField 

Inc. 

4:00 PPP15 516.20 3D X-ray computed tomography of 

excised rodent brain at submicrometric resolution using 

metallic intracellular contrast medium. F. HAMZEI-SICHANI*; 

K. SIMONYAN; P. HOF; A. KORETSKY; D. MORRIS. Mount 

Sinai Sch. of Med., Natl. Inst. of Health, NINDS. 

1:00 PPP16 516.21 Whole NANOSYMPOSIUM imaging 

system: A valuable tool for neuroscience research. A. 

KULKARNI; C. STANTON; M. G. HONIG*; C. R. HANDORF; 

R. S. WATERS. Univ. Tennessee Sch. of Med. 

2:00 PPP17 516.22 A high throughput image analysis strategy 

for analysis of in situ hybridization transcript patterns in the 

SOD1_G93A mouse model of ALS. J. LINCECUM*; M. Z. 

WANG; R. PUCHALSKI; R. SANCHEZ; I. CARRION; F. 

VIEIRA; S. PERRIN. ALS Therapy Develop. Inst., Allen Inst. 

for Brain Sci. 

3:00 PPP18 516.23 Tape-transfer assisted cryosectioning for 

the mouse brain architecture project. V. PINSKIY*; J. JONES; 

H. WANG; H. COX; P. MITRA. Cold Spring Harbor Lab., Stony 

Brook Univ. 

4:00 PPP19 516.24 Increased zinc levels in 129S1 inbred 

mouse strain determined by synchrotron X-ray fluorescence 

microscopy. C. M. GROEBER*; R. TAPPERO; J. M. FLINN. 

George Mason Univ., Brookhaven Natl. Lab. 

1:00 PPP20 516.25 Single-synapse analysis with array 

tomography. B. BUSSE; K. D. MICHEVA*; N. WEILER; S. 

SMITH. Stanford Univ. Sch. Med. 

2:00 PPP21 516.26 Analysis of individual glutamatergic and 

gabaergic synapses in human cerebral cortex using array 

tomography. N. A. O’ROURKE*; K. D. MICHEVA; B. L. 

BUSSE; S. J. SMITH. Stanford Univ. 



ABSTRACT 

NUMBER STATEMENT 

Conflict of Interest Statements 

The following presenters, signified by a dot (•) in the program, indicated a real or perceived conflict of interest. 

Presenters listed without a dot in the program had no financial relationships to disclose. 

311.5 C.E. finch , Acumen Pharmaceuticals, co-founder and part 

owner, Ownership Interest. 

312.5 T.L. Bale, AstraZeneca, Research Grant. 

314 E. Boyden, Eos Neuroscience, Ownership Interest. 

314.2 E.S. Boyden, Eos Neuroscience, Ownership Interest. 

315 D.A. Lewis, BMS Foundation, Research Grant; Bristol-Myers 

Squibb, Research Grant; Curridium Ltd, Research Grant; 

Pfizer, Research Grant; AstraZeneca, Consultant/Advisory 

Board; Bioline RX, Consultant/Advisory Board; Bristol- 

Myers Squibb, Consultant/Advisory Board; Hoffman-Roche, 

Consultant/Advisory Board; Lilly, Consultant/Advisory Board; 

Merck, Consultant/Advisory Board; Neurogen, Consultant/ 

Advisory Board; SK Life Science, Consultant/Advisory Board. 

315.3 D.A. Lewis, investigator-initiated research support from the 

BMS Foundation, B; consultant in the areas of target F; 

318.2 S. Rieger, UCLA, Employment; A. Sagasti, UCLA, 

Employment. 

318.3 Z. Wang, Natural Science Foundation of China, Research 

Grant. 

318.5 C. heine, Translational Centre for Regenerative Medicine - 

Leipzig, University of Leipzig, Germany, Research Grant 

320.1 C.G. Glabe, Kinexis, Consultant/Advisory Board. 

320.6 L.N. Nilsson, BioArctic Neuroscience, Consultant/Advisory 

Board; A. Lord, BioArctic Neuroscience, Employment; L. 

Lannfelt, BioArctic Neuroscience, Ownership Interest. 

320.10 C. Tan hehir, General Electric, Employment; T. Tanner, 

General Electric, Employment; Z. Pang, General Electric, 

Employment; N. Barnhardt, General Electric, Employment; J. 

Klimash, General Electric, Employment; T. Murray, General 

Electric, Employment. 

321.13 J. Nussbaum,, Research support from Probiodrug AG, Other 

Research Support; h. Cynis, An employee (Propject Leader) 

of Probiodrug AG, a private German Biotech company, 

active in drug discovery to combat neurodegeneration. He 

possesses stock options in the company., Employment; S. 

Schilling, An employee (Department Head) of Probiodrug AG, 

a private German Biotech company, active in drug discovery 

to combat neurodegeneration. He possesses stock options 

in the company., Employment; h. Demuth, An employee 

(CSO) of Probiodrug AG, a private German Biotech company, 

active in drug discovery to combat neurodegeneration. 

He possesses stock and stock options in the company., 

Employment; G.S. Bloom, Research support from Probiodrug 

AG, Other Research Support. 

323.3 V.J. Strecher, Dr. Strecher is the Chief Visionary Officer, 

Founder, and Shareholder of HealthMedia, a company that 

develops and licenses computer-tailored health promotion, 

disease prevention and managment tools., Employment; 

Dr. Strecher has consulted for pharmaceutical companies 

that market computer-tailored smoking cessation programs., 

Consultant/Advisory Board. 

323.5 S. Kapur, Indian Council of Medical Research, India, 

Research Grant; A. Pal, Senior Research Fellowship from 

Council of Scientific and Industrial Research, India, Other 

Research Support. 

324.1 K. Kornysheva, Institute of Cognitive Neuroscience UCL, 

Employment. 

329.7 L.M. Williams, Australian Research Council, Research Grant; 

National Health & Medical Research Council, Research 

Grant; Consultant, Brain Resource, Consultant/Advisory 

ABSTRACT 


Board; Stockholder, Brain Resource, Other; S.h. Koslow, 

Consultant, Brain Resource, Consultant/Advisory Board; 

J.M. Gatt, Fees, Brain Resource, Other; P.R. Schofield, 

Stock options, Brain Resource, Other; E. Gordon, CEO and 

Chairman, Brain Resource, Employment. 

330.13 M. Choi, University of Cambridge, Employment; Medical 

Research Council, Research Grant; Hereditary Disease 

Foundation, Other Research Support. 

330.15 R. Beckervordersandforth, Miltenyi Biotec GmbH, Germany, 

Speakers Bureau/Honoraria. 

330.23 J.A. Kelleher-Andersson, Neuronascent Inc., Ownership 

Interest; M.S. Wells, Neuronascent Inc., Employment; R.C. 

McGee, Lifeline Cell Technologies, Employment. 

330.24 C.L. Benn, Pfizer, Employment; M. Bictash, Pfizer, 

Employment; h. Boyd, Pfizer, Employment; M.E. Bunnage, 

Pfizer, Employment; D. Carter, Pfizer, Employment; 

P. Choudhary, Pfizer, Employment; A. Cook, Pfizer, 

Employment; P.V. fish, Pfizer, Employment; J.E.J. Mills, 

Pfizer, Employment; A. Pannifer, Pfizer, Employment; 

C. Phillips, Pfizer, Employment; K. Skinner, Pfizer, 

Employment; C. Walden, Pfizer, Employment. 

331.8 J. hyun, R31-2008-000-100069-0, 2009-0093829, Research 

Grant. 

331.13 L. Katsimpardi, GlaxoSmithKline, Other Research Support; 

N. Tsujimoto, GlaxoSmithKline, Other Research Support; 

B. Biscaro, GlaxoSmithKline, Other Research Support; Q. 

Ma, GlaxoSmithKline, Other Research Support; J. Scholz, 

GlaxoSmithKline, Other Research Support; C. Brenneis, 

GlaxoSmithKline, Other Research Support; B. Wainger, 

GlaxoSmithKline, Other Research Support; C.J. Woolf, 

GlaxoSmithKline, Other Research Support; L.L. Rubin, 

GlaxoSmithKline, Other Research Support. 

334.1 C.P. Turner, NIH RO1051632, Research Grant. 

335.1 X. Wei: University of Pittsburgh; Employment, EY016099; 

Research Grant, RPB career development award; Other 


335.14 P. huang, NSC-97-2311-B-002-007-MY3, Research Grant; 

NSC-97-2321-B-002-042, Research Grant; NSC-98- 

2321-B-002-009, Research Grant; Y. Chen, NSC-97-2311- 

B-002-007-MY3, Research Grant; NSC-97-2321-B-002-042, 

Research Grant; NSC-98-2321-B-002-009, Research 

Grant; C. Wang, NSC-97-2311-B-002-007-MY3, Research 

Grant; NSC-97-2321-B-002-042, Research Grant; NSC-98- 

2321-B-002-009, Research Grant. 

336.8 J.E. Sparling: University of Ottawa; Employment, NSERC; 

Research Grant. 

336.11 K. Chen, NIMH, Research Grant; J.C. Shih, NIMH, Research 

Grant. 

337.6 T.A. Lanz, Pfizer, Inc., Employment; C.D. Pilsmaker, 

Pfizer, Inc., Employment; E.M. Drummond, Pfizer, Inc., 

Employment; S.E. Bove, Pfizer, Inc., Employment; W.O. 

Adamowicz, Pfizer, Inc., Employment; S.J. Engle, Pfizer, 

Inc., Employment; J.A. Dumin, Pfizer, Inc., Employment; R.J. 

Kleiman, Pfizer, Inc., Employment. 

337.8 S.E. Bove, Pfizer, Inc., Employment; A. Mariga, Pfizer, Inc., 

Employment; T.A. Lanz, Pfizer, Inc., Employment; G.W. 

Cadelina, Pfizer, Inc., Employment; W.O. Adamowicz, Pfizer, 

Inc., Employment; C.D. Pilsmaker, Pfizer, Inc., Employment; 

J.A. Dumin, Pfizer, Inc., Employment; R.J. Kleiman, Pfizer, 

Inc., Employment. 

337.10 Y. fukuda, Nippon Zoki Pharmaceutical Co. Ltd., 

Neuroscience 2010 | Monday | 157

ABSTRACT 


Employment; MUSC Foundation for Research Development, 

Other Research Support; K. fukuhara, Nippon Zoki 

Pharmaceutical Co. Ltd., Employment. 

338.2 J.R. Pugh, Vollum Institute, Employment; MH074989, 

Research Grant; NS007381, Research Grant. 

338.6 K. Podolski, NeuroProof GmbH, Employment; B.M. Bader, 

NeuroProof GmbH, Employment; O.h.U. Schroeder, 

NeuroProof GmbH, Ownership Interest; A. Gramowski, 

NeuroProof GmbH, Ownership Interest. 

338.16 J.J. harp, NIN/NCMHHD, Research Grant. 

339.15 R.A. Neff, Johnson & Johnson, Employment; A. 

Bhattacharya, Johnson & Johnson Pharmaceutical Research 

and Development LLC, Employment; A.D. Wickenden, 

Johnson & Johnson, Employment; Q. Wang, Johnson 

& Johnson, Employment; N. Wu, Johnson & Johnson, 

Employment; M.P. Maher, Johnson & Johnson, Employment. 

339.17 B.M. Olivera, BMO is a cofounder of Cognetix, Inc., 

Ownership Interest; G. Bulaj, GB is a cofounder of 

NeuroAdjuvants, Inc., Ownership Interest. 

339.22 S. Ding, University of Tennessee Health Science Center, 

Employment; f. Zhou, University of Tennessee Health 

Science Center, Employment; NIH R01DA021194, 

R01NS058850, Research Grant; American Parkinson Disease 

Association; Other. 

340.7 S. Takahashi, Astellas Pharma Inc, Employment; K. Inamura, 

Astellas Pharma Inc, Employment; A. Miyake, Astellas 

Pharma Inc, Employment. 

340.8 J.R. Schwarz, Deutsche Forschungsgemeinschaft, Research 

Grant. 

340.13 V. Gazula, Yale University, Employment. 

340.21 D.M. haluk, NIH grants RO1 MH061933, P50 DA011806, 

and R21 DA029343-01 (KW)., Research Grant; D. Arora, NIH 

grants RO1 MH061933, P50 DA011806, and R21 DA029343- 

01 (KW)., Research Grant; K. Wickman, NIH grants RO1 

MH061933, P50 DA011806, and R21 DA029343-01 (KW)., 


342.4 G.A. Gerhardt: Quanteon; Ownership Interest. 

343.8 h.W. Lee, KRF-2009-006-5721, Research Grant 

343.9 M.T. Bianchi, Clinical Investigator Training Program: 

Harvard/MIT Health Sciences and Technology – Beth Israel 

Deaconess Medical Center, in collaboration with Pfizer, Inc. 

and Merck &Co, Other Research Support. 

343.18 A.W. Przybyszewski, FHC, Employment; NIH, Research 

Grant. 

344.1 V. Kasymov, Wellcome Trust, Research Grant; O. Larina, 

Wellcome Trust, Research Grant; A.V. Gourine, Wellcome 

Trust, Research Grant. 

344.11 Y. Bernardinelli, PBLAB-118155 and PA00A3-121419/1 from 

the Swiss National Science Foundation, Research Grant; K.K. 

Murai, CIHR, Canada Research Chairs Program, Canadian 

Foundation for Innovation, EJLB Foundation, Research Grant. 

344.16 C.J. Lee, Center for Neural Science, KIST, Employment; 

Center for Functional Connectomics, KIST, Employment. 

344.17 U. Lo, R01NS061983, Research Grant. 

344.22 B.A. MacVicar, 1. Canadian Institutes of Health Research 

2. Transatlantic Networks of Excellence Program from the 

Foundation Leducq, Research Grant. 

345.12 f. Richter, IZKF Jena University Hospital, Research Grant; 

A. Lehmenkuhler, IZKF Jena University Hospital, Research 

Grant; h. Schaible, IZKF Jena University Hospital, Research 

Grant. 

345.13 A.D. Sherpa, Departmant of Cell Biology, SUNY Downstate 

Medical Center, Brooklyn, NY, Employment; NIH NINDS 

Grant NS047557, Research Grant; P. Van de Nes, SUNY 


ABSTRACT 


Downstate Medical Center, Brooklyn, NY, Employment; f. 

Xiao, NIH NINDS Grant NS047557, Research Grant; S. 

hrabetova, SUNY Downstate Medical Center, Brooklyn, NY, 

Employment; NIH NINDS Grant NS047557, Research Grant. 

345.14 K. fukui, Shibaura Institute of Technology, Employment; 

Hokkaido University, Employment; The Ministry of Education, 

Culture, Sports, Science, and Technology of Japan, Research 

Grant; The Akiyama Foundation, Research Grant; h. 

Takatsu, Shibaura Institute of Technology, Employment; 

Industrial University of Selangor, Employment; S. Urano, 

Shibaura Institute of Technology, Employment; The Ministry 

of Education, Culture, Sports, Science, and Technology 

of Japan, Research Grant; T. Koike, Hokkaido University, 

Employment; The Ministry of Education, Culture, Sports, 

Science, and Technology of Japan, Research Grant. 

346.9 S.C. Joachim, Deutsche Forschungsgemeinschaft (DFG JO- 

886/1-1), Research Grant. 

346.16 A. Capuano, Merck grant, Research Grant; P. Navarra, 

Merck Grant, Research Grant. 

347.3 J.P. Corradi, Bristol-Myers Squibb Company, Employment; 

L. Yang, Bristol-Myers Squibb Company, Employment; N. 

hoque, Bristol-Myers Squibb Company, Employment; P. 

Poundstone, Bristol-Myers Squibb Company, Employment; 

V. Patel, Bristol-Myers Squibb Company, Employment; L. 

DeCarr, Bristol-Myers Squibb Company, Employment; C. 

Andorfer, Bristol-Myers Squibb Company, Other Research 

Support; A.M. Cacace, Bristol-Myers Squibb Company, 

Employment; D. Barten, Bristol-Myers Squibb Company, 

Employment. 

347.5 A.A. Protter, Medivation, Employment; M. Giorgetti, 

Medivation, Employment; M. Mitrovic, JSW Life Sciences, 

Employment; S. Duller, JSW Life Sciences, Employment; R. 

Rabl, JSW Life Sciences, Employment; B. hutter-Paier, JSW 

Life Sciences, Employment. 

347.6 P.D. Wes, Bristol-Myers Squibb, Employment; A. Easton, 

Bristol-Myers Squibb, Employment; M.A. Seager, Bristol- 

Myers Squibb, Employment; N.X. Barrezueta, Bristol-Myers 

Squibb, Employment; C. Bourin, Bristol-Myers Squibb, 

Employment; J. hogan, Bristol-Myers Squibb, Employment; 

A. Truong, Bristol-Myers Squibb, Employment; A. he, 

Bristol-Myers Squibb, Employment; D. Barton, Bristol-Myers 

Squibb, Employment; A.M. Cacace, Bristol-Myers Squibb, 

Employment. 

347.7 T. Miyasaka, JSPS KAKENHI, Grant-in-Aid for Young 

Scientists (B), Research Grant; Y. Ihara, Core Research 

for Evolutional Science and Technology, Research 

Grant; Scientific Research on Priority Areas-Research on 

Pathomechanisms of Brain Disorders, Research Grant. 

347.18 D.M. Barten, Bristol-Myers Squibb, Employment; L. Yang, 

Bristol-Myers Squibb, Employment; G. Cadelina, Bristol- 

Myers Squibb, Employment; N. hoque, Bristol-Myers 

Squibb, Employment; L. DeCarr, Bristol-Myers Squibb, 

Employment; V. Guss, Bristol-Myers Squibb, Employment; S. 

Sankaranarayanan, Bristol-Myers Squibb, Employment; J. 

Meredith, Bristol-Myers Squibb, Employment; M. Ahlijanian, 

Bristol-Myers Squibb, Employment; C.f. Albright, Bristol- 

Myers Squibb, Employment. 

347.25 G. Cole, NIH NS43946, Research Grant; C. Miller, NIA 

AG18879, Research Grant; K. Gylys, NIH 5AG016570, 


347.27 S.J. Glover, Employees of Eli Lilly and Company Ltd, 

Employment; J. Wolak, Employee of Eli Lilly and Company 

Ltd, Employment; T.K. Murray, Employee of Eli Lilly and 

Company Ltd, Employment; C.V. Cella, Employee of Eli 

Lilly and Company Ltd, Employment; R. Purcell, Employee 

of Eli Lilly and Company Ltd, Employment; N. Buckner, 

Employee of Eli Lilly and Company Ltd, Employment;

ABSTRACT 


M.J. O’Neill, Employee of Eli Lilly and Company Ltd, 

Employment; V. Lakics, Employee of Eli Lilly and Company 

Ltd, Employment; I. Lavenir, MRC, Employment; M. Goedert, 

MRC, Employment; P. Davies, Albert Einstein College of 

Medicine, Employment; M.L. hutton, Employee of Eli Lilly 

and Company Ltd, Employment; P.G. Szekeres, Employee of 

Eli Lilly and Company Ltd, Employment. 

347.28 J.N. Marcus, Merck and Co, Inc, Employment; A. hughes, 

Merck and Co, Inc, Employment; R. Kennan, Merck and 

Co, Inc, Employment; C. Wolffe, Merck and Co, Inc, 

Employment; M. Pearson, Merck and Co, Inc, Employment; 

X. Wang, Merck and Co, Inc, Employment; J. Renger, Merck 

and Co, Inc, Employment; M. Savage, Merck and Co, Inc, 

Employment. 

347.29 R. Bhat, AstraZeneca R&D, Employment 

348.1 D.C. German, University of Texas Southwestern Medical 

Center, Employment; NIH grants AG034285, AG12300, DP 

10DO0066301, Michael J. Fox Foundation for Parkinson’s 

Research, Research Grant. 

348.7 B. Kepplinger, Secretary of Austrian Pain Society, Speakers 

Bureau/Honoraria; Hospital Director NÖ Landesklinikum 

Mauer, Speakers Bureau/Honoraria; NÖ Landesklinikum 

Mauer, Employment; NÖ Landesklinikum Amstetten, 

Employment; Karl Landsteiner Institut Mauer, Employment; 

Österreichische Nationalbank Jubilaeumsfonds Project 

Nr. 12316, Research Grant; h. Baran, Karl Landsteiner 

Institut Mauer, Employment; Österreichische Nationalbank 

Jubilaeumsfonds Project Nr. 12316, Research Grant; 

International Journal of Tryptophan Research, Consultant/ 

Advisory Board. 

348.9 J.N. Shier, NIDCD R01 DC 005935, Research Grant; M.R. 

Ciucci, NIDCD P30 DC 010754, Research Grant; N.P. 

Connor, NIDCD R01 DC 005935, Research Grant. 

348.10 h. Baran, Karl Landsteiner Research Institute Mauer, 

Employment; Austrian National Bank Jubiläumsfonds 

Project: Nr. 12316, Research Grant; International Journal 

of Tryptophan Research, Consultant/Advisory Board; B. 

Kepplinger, NÖ Landesklinikum Mauer, Employment; NÖ 

Landesklinikum Amstetten, Employment. 

348.17 P.D. Coleman, Sun Health Research Institute, Employment; 

N. Berchtold, UC Irvine, Employment; AG 023173, Research 

Grant; D. Cribbs, UC Irvine, Employment; AG 023173, 

Research Grant; P50 AG 16573, Research Grant; A. Grover, 

Sun Health Research Institute, Employment; AG 036400, 

Research Grant; J. Rogers, Sun Health Research Institute, 

Employment; C.W. Cotman, UC Irvine, Employment; R01 AG 

023173, Research Grant; P50 AG 16573, Research Grant; 

R01 AG 00538, Research Grant. 

348.21 C.A. Mathis, GE Healthcare, Other; W.E. Klunk, GE 

Healthcare, Other 

349.3 R.D. King, Alzheimer’s Association, Research Grant; Robert 

Wood Johnson Foundation, Research Grant. 

349.9 D. Sehlin, The Swedish Research Council, Research Grant; 

Stohnes Stiftelse, Research Grant; f. Ekholm Pettersson, 

Stohnes Stiftelse, Research Grant; Åhléns Stiftelse, Research 

Grant; Stiftelsen Gamla Tjänarinnor, Research Grant; h. 

Englund, Alzheimerfonden, Research Grant; Stiftelsen 

Gamla Tjänarinnor, Research Grant; Stohnes stiftelse, 

Research Grant; L. Lannfelt, Hjärnfonden, Research 

Grant; Bertil Hållstens forskningsstiftelse, Research Grant; 

Alzheimerfonden, Research Grant; The Swedish Research 

Council, Research Grant; Founder of BioArctic Neuroscience 

AB, Ownership Interest; S. Paulie, Ownership in Mabtech AB, 

Ownership Interest. 

349.16 C. Cotman, NIH/NIA Grant AG12694, Research Grant. 

349.26 A.M. Dale, General Electric Medical Foundation, Other 

Research Support; CorTechs Labs, Inc., Ownership Interest; 

ABSTRACT 


CorTechs Labs, Inc., Consultant/Advisory Board; J.B. Brewer, 

Janssen Alzheimer Immunotherapy, Research Grant; General 

Electric Medical Foundation, Other Research Support. 

349.27 A.M. Dale, CorTechs Labs, Inc., Ownership Interest; 

CorTechs Labs, Inc., Consultant/Advisory Board 

349.28 J.B. Brewer, General Electric Medical Foundation, Other 

Research Support; Janssen Alzheimer Immunotherapy, Other 


350.1 J. Engel, NIH grants NS 02808 and NS 33310, Research 

Grant; A. Bragin, NIH NS 02808 and NS 33310, Research 

Grant. 

350.7 C. Sandoval Salazar, University of Guadalajara, Other; 

A. Morales-Villagran, Universidad de Guadalajara, Other; 

J. Ortega-Ibarra, Universidad de Guadalajara, Other; V. 

Palomera-Avalos, Universidad de Guadalajara, Other. 

350.27 E. Garrido-Sanabria, NIH grants 5SC1NS063950-04, 

Research Grant; 3SC1NS063950-03S1 (ARRA), Research 

Grant. 

351.9 P. Lyden, ZZ Biotechnology, Consultant/Advisory Board; 

Photothera, Consultant/Advisory Board. 

351.10 K. van Leyen, NIH, Research Grant. 

353.18 J.R. Moyer, Quincy Bioscience, LLC, Other Research 

Support. 

353.25 f.A. Medina, R01 EB002019 (National Institutes of Health), 


354.3 J. Yi, Center for Neuroscience and Regenertive Medicine, 

Uniformed Servies University of the Health Sciences, 

Bethesda, Maryland 20814, Employment. 

354.10 N.A. Terpolilli, FöFoLe Grant 669, University of Munich, 


354.24 B.C. Mouzon, This research was funded by a Department of 

Defense award (W81XWH-07-1-0700) to Dr. Fiona Crawford, 


355.6 L. Li, University of Ilinois at Chicago, Employment; B.S. 

Prabhakar, University of Illinois at Chicago, Employment; 

M.N. Meriggioli, UIC, Employment. 

356.8 R.E. hartman, California Table Grape Commission, Research 

Grant. 

356.9 T. Sutula: Ownership Interest; Neurogenomex, Inc.. 

356.10 A. hånell, The anti-Lingo-1 antibody was kindly provided 

by Novartis AG without any additional financial support, 

Other Research Support; A. Walmsley, Novartis AG, Basel, 

Switzerland, Employment. 

358.12 Z. he, financial interests in a company formed to advance 

therapies for axon regeneration after spinal cord injury, 

Other; O. Steward, financial interests in a company formed 

to advance therapies for axon regeneration after spinal cord 

injury, Other. 

358.15 P.M. Mattsson, Bioarctic, Research Grant; M.A. Svensson, 

Bioarctic, Research Grant; J. Sjödahl, Bioarctic, Employment. 

360.10 S. Rose, King’s College London, Employment; Parkinson’s 

Disease Society, Research Grant; Rosetrees Trust, 

Research Grant; Cure PD, Research Grant; Proximagen 

Neuroscience, Consultant/Advisory Board; P. Jenner, 

King’s College London, Employment; Parkinson’s Disease 

Society, Research Grant; Rosetrees Trust, Research Grant; 

Cure PD, Research Grant; GlaxoSmithKline, Speakers 

Bureau/Honoraria; Novartis, Speakers Bureau/Honoraria; 

Orion, Speakers Bureau/Honoraria; Boehringer Ingelheim, 

Speakers Bureau/Honoraria; Teva, Speakers Bureau/ 

Honoraria; Lundbeck, Speakers Bureau/Honoraria; UCB, 

Speakers Bureau/Honoraria; 3% Proximagen Neuroscience, 

Ownership Interest; FP Pharmaceuticals, Consultant/Advisory 

Board; Boehringer Ingelheim, Consultant/Advisory Board; 

GlaxoSmithKline, Consultant/Advisory Board; Novartis, 

Neuroscience 2010 | Monday Conflict of Interest Statements | 159

ABSTRACT 


Consultant/Advisory Board; Teva, Consultant/Advisory Board; 

Orion, Consultant/Advisory Board. 

362.3 D.A. Lewis, BioLine RX, Consultant/Advisory Board; BMS 

Foundation, Other Research Support; Bristol-Myers Squibb, 

Other Research Support; Curridium Ltd, Other Research 

Support; Pfizer, Other Research Support; AstraZeneca, 

Consultant/Advisory Board; Bristol-Myers Squibb, Consultant/ 

Advisory Board; Hoffman-Roche, Consultant/Advisory Board; 

Lilly, Consultant/Advisory Board; Merck, Consultant/Advisory 

Board; Neurogen, Consultant/Advisory Board; SK Life 

Science, Consultant/Advisory Board. 

362.5 D.A. Lewis, BMS Foundation, Other Research Support; 

Bristol-Myers Squibb, Other Research Support; Curridium 

Ltd., Other Research Support; Pfizer, Other Research 

Support; AstraZeneca, Consultant/Advisory Board; BioLine 

RX, Consultant/Advisory Board; Bristol-Myers Squibb, 

Consultant/Advisory Board; Hoffman-Roche, Consultant/ 

Advisory Board; Lilly, Consultant/Advisory Board; Merck, 

Consultant/Advisory Board; Neurogen, Consultant/Advisory 

Board; SK Life Science, Consultant/Advisory Board. 

362.7 S. Ghose, NIMH, Research Grant; Stanley Medical Research 

Institute, Research Grant. 

362.8 D.A. Lewis, BMS Foundation, Research Grant; Bristol-Myers 

Squibb, Research Grant; Curridium Ltd., Research Grant; 


Board; BioLine RX, Consultant/Advisory Board; Bristol- 




Advisory Board; SK Life Science, Consultant/Advisory 

Boarde. 


















Bristol-Myers Squibb, Other Research Support; Curridium Ltd, 

Other Research Support; Pfizer, Other Research Support; 

AstraZeneca, Consultant/Advisory Board; BioLine RX, 





Science, Consultant/Advisory Board 


Bristol-Myers Squibb, Other Research Support; Curridium Ltd, 

Other Research Support; Pfizer, Other Research Support; 

AstraZeneca, Consultant/Advisory Board; BioLine RX, 





Science, Consultant/Advisory Board. 

363.9 N.M. Richtand, AstraZeneca Pharmaceulticals, Other 

Research Support; Ortho McNeil Janssen Scientific 

Affairs, L.L.C, Research Grant; Merck, Speakers Bureau/ 


ABSTRACT 


Honoraria; Novartis, Speakers Bureau/Honoraria; Bristol- 

Meyers Squibb, Speakers Bureau/Honoraria; Bristol-Meyers 

Squibb, Consultant/Advisory Board; Gerson Lehrman Group, 


363.11 S. Rayport, MatTek Corporation, Consultant/Advisory Board. 

363.13 J.T. Coyle, Bristol-Myers Squibb, Research Grant; Abbott 

(stock), Ownership Interest; Abbott, Consultant/Advisory 

Board; Bristol-Myers Squibb, Consultant/Advisory Board; 

Bioavail, Consultant/Advisory Board; Puretech, Consultant/ 

Advisory Board; patent for the use of D-serine in the treatment 

of serious mental illness, Other. 

363.26 V. Lakics, Employee of Eli Lilly & Co. Ltd., Employment; N. 

Malik, Employee of Eli Lilly & Co. Ltd., Employment; M.D. 

Tricklebank, Employee of Eli Lilly & Co. Ltd., Employment; 

M.J. O’Neill, Employee of Eli Lilly & Co. Ltd., Employment 

364.9 J. Perez, MH05885 Veterans Affairs Center of Excellence for 

Stress and Mental Health, Research Grant; M. Geyer, MAG 

has an equity interest in San Diego Instruments., Ownership 

Interest. 

364.13 J.A. Araujo, CanCog Technologies Inc., Employment; 

CanCog Technologies Inc., Ownership Interest; C. de Rivera, 

CanCog Technologies Inc., Employment; N.W. Milgram, 

billm@cancog.com, Employment; billm@cancog.com, 


365.2 K. Kelson, n/a, Employment; AA07680,AA017991, 

Research Grant; n/a, Other Research Support; alcohol 

dependence, Ownership Interest; RW. Olsen & J. Liang, 

Consultant/Advisory Board; V. Lim, n/a, Employment; 

AA07680,AA017991, Research Grant; n/a, Other Research 

Support; n/a, Speakers Bureau/Honoraria; alcohol 

dependence, Ownership Interest; RW Olsen & J. Liang, 

Consultant/Advisory Board; n/a, Other; S. Bucley, n/a, 

Employment; AA07680, AA017991, Research Grant; n/a, 

Other Research Support; n/a, Speakers Bureau/Honoraria; 

alcohol dependence, Ownership Interest; RW Olsen/J Liang, 

Consultant/Advisory Board; K. Jeong, n/a, Employment; C. 

Tu, n/a, Employment; A. Basa, n/a, Employment; T. Lam, 

n/a, Employment; I. Spigelman, UCLA School of Dentistry, 

Employment; AA016100, Research Grant; professor, 

Speakers Bureau/Honoraria; alcohol dependence, Ownership 

Interest; J. Liang, UCLA School of Dentistry, Employment; 

AA016100, Research Grant; AA07680,AA016100, Other 

Research Support; n/a, Speakers Bureau/Honoraria; alcohol 

dependence, Ownership Interest; n/a, Consultant/Advisory 

Board; n/a, Other; R.W. Olsen, David Geffen School of 

Medicine At UCLA, Employment; AA07680, Research Grant. 

365.7 X. Ju, R01, Research Grant. 

365.8 B.M. Walker, Lundbeck Research USA, Inc., Research Grant. 

365.13 G.f. Koob, 2U01AA013517-06, Research Grant; B.L. Kieffer, 

1U01AA016658-01, Research Grant. 

365.21 S. Ahmadiantehrani, Merck Laboratories Research Fellow 

award (SA), Research Grant. 

366.1 A.J. Lesselyong, Microtransponder, Inc., Consultant/Advisory 

Board; W. Rosellini, Microtransponder, Inc., Ownership 

Interest; T. Schallert, Microtransponder, Inc., Other Research 

Support; M. Kilgard, Microtransponder, Inc., Other Research 

Support. 

366.10 J. Liu, Key Laboratory of Animal Models and Human 

Disease Mechanisms of Chinese Academy of Sciences & 

Yunnan Province, Kunming Institute of Zoology, Kunming, 

Yunnan, 650223, Employment; State Key Laboratory of Drug 

Research, Shanghai Institute of Materia Medica, Chinese 

Academy of Sciences, Shanghai 201203, China, Employment; 

the National Basic Research Program grant from the Ministry 

of Science and Technology of China (2009CB522000), 

Research Grant; National Science Fund for Distinguished 

Young Scholar from the National Natural Science Foundation

ABSTRACT 


of China (30425002), Research Grant; National Science Fund 

of China (30530250), Research Grant; Science Foundation of 

Chinese Academy of Sciences (KSCXI/YW/R/68), Research 

Grant. 

368.16 S. Eitan, Texas A&M University, Employment; Hogg 

Foundation, Research Grant; P.J. Wellman, Texas A&M Univ, 

Employment. 

368.25 M.W. Walker, Lundbeck Research USA, Employment. 

371.1 E.R. Petrus, NIH (R01-EY014882 and R21-NS070645), 


371.4 J. Weiland, J. Weiland, Second Sight Medical Products, 

B. Research Grant (principal investigator, collaborator or 

consultant and pending grants as well as grants already 

received), Research Grant. 

371.5 N.K. Logothetis, Devision of imaging science and biomedical 

engineering, University of Manchester, Employment. 

372.1 C.R. Mullin, OGSST, Research Grant; J.K. Steeves, NSERC, 


372.14 Y. Wang, University of Texas-Houston Medical School, 

Employment; James S. McDonnell Foundation, Pew Scholars 

Program, Research Grant; V. Dragoi, University of Texas- 

Houston Medical school, Employment; James S. McDonnell 

Foundation, Pew Scholars Program, Research Grant. 

372.17 D. Mantini, FWO A 4/5 SDS 15387, Research Grant. 

373.12 A.G. Mahon, NSERC, Research Grant; Trent University, 

Research Grant; L. Brown, NSERC, Research Grant; Trent 

University, Research Grant. 

373.16 L.C. Pelland, Ontario Neurotrauma Foundation, Research 

Grant; S.h. Scott, Canadian Foundation for Innovation, CIHR, 


373.21 M.G. Rosa, FP7-ICT 217077-EYESHOTS, MIUR, Fondazione 

del Monte di Bologna e Ravenna, ARC, Research Grant. 

374.11 M. Demeule, Angiochem, Employment; Angiochem, 

Ownership Interest; A. Régina, Angiochem, Employment; 

Angiochem, Ownership Interest; C. Thiot, Angiochem, 

Employment; Angiochem, Ownership Interest; C. Ché, 

Angiochem, Employment; Angiochem, Ownership Interest; R. 

Béliveau, Angiochem, Ownership Interest; Angiochem, 

Consultant/Advisory Board; J. Castaigne, Angiochem, 

Employment; Angiochem, Ownership Interest. 

374.13 J.V. Mulcahy, SiteOne Therapeutics, Ownership Interest; 

S. Biswal, SiteOne Therapeutics, Ownership Interest; D.C. 

Yeomans, SiteOne Therapeutics, Ownership Interest; G.P. 

Miljanich, SiteOne Therapeutics, Ownership Interest; J. Du 

Bois, SiteOne Therapeutics, Ownership Interest. 

374.15 E. Chung, Korea Research Foundation(KRF) grant (No.2010- 

0017324), Research Grant; h. Bae, This work was supported 

by the Korea Science and Engineering Foundation (KOSEF) 

grant funded by the Korea government (MEST) (No. 2009- 

0063466)., Research Grant. 

374.16 C.M. Peters, This work was supported in part by grant 

GM48085 from the National Institutes of Health, Bethesda 

MD, Research Grant. 

374.17 T. Qu, 1) The Boothroyd Foundation and AHAF grants to 

T. Qu, 2) NIH grant R01 NS052372 to J. Cheng, Research 

Grant. 

375.3 B.J. Kerr, Multiple Sclerosis Society of Canada, Research 

Grant. 

375.15 L. Pook, Algos Preclinical Services, Employment; T.L. healy, 

ALgos Preclinical Services, Employment; S.L. Gottshall, 

Algos Preclinical Services, Employment. 

375.16 T. Mathew, RR-03071, Research Grant; MIDARP DA- 12136, 


376.1 C.C. Toth, Univ. of Calgary, Employment; AHFMR, CIHR, 

ABSTRACT 


JDRF, Research Grant; Pfizer, Valeant, Other Research 

Support; Pfizer, Valeant, Boehringer-Ingelheim, Speakers 

Bureau/Honoraria; W.h. frey, U. of Minnesota, Employment. 

377.2 f. Panetsos, COMPLUTENSE UNIVERSITY OF MADRID, 

Employment. 

378.3 P.E. Garay, Allergan Inc., Employment; Allergan Inc., 

Ownership Interest; J.A. Ross, Allergan Inc., Other 

Research Support; B.P.S. Jacky, Allergan Inc., Employment; 

Allergan Inc., Ownership Interest; D.J. Williams, Allergan 

Inc., Employment; Allergan Inc., Ownership Interest; M.A. 

Gilmore, Allergan Inc., Employment; Allergan Inc., Ownership 

Interest; J.V. Ordas, Allergan Inc., Employment; Allergan Inc., 

Ownership Interest; L.E. Steward, Allergan Inc., Employment; 

Allergan Inc, Ownership Interest; R. Aoki, Allergan Inc., 

Employment; Allergan Inc, Ownership Interest; E. fernandez- 

Salas, Allergan Inc., Employment; Allergan Inc, Ownership 

Interest. 

378.11 T. hodics, K23HD050267 by NIH NICHD, Research Grant. 

379.7 J. Ucran, Acceleron Pharma, Ownership Interest. 

379.9 K.R. Wagner, NIH Grant, Research Grant. 

381.8 G.P. Siegmund, GPS partly owns MEA Forensic Engineers 

& Scientists., Ownership Interest; MEA Forensic Engineers 

& Scientists may obtain consulting work related to this 

knowledge., Consultant/Advisory Board. 

381.17 L. Janssens, Research Foundation – Flanders (1.5.104.03 

and G.0674.09), Research Grant. 

382.11 h. Mao, ECS-0702057, Research Grant. 

384.4 N.L. Garcia Saldivar, UNAM, Employment; M.R.A. 

González-López, UNAM FES Iztacala, Employment; G. 

Castillo-Roberto, FES Iztacala UNAM, Employment; R. 

Domínguez, FES Zaragoza UNAM, Research Grant; S.E. 

Cruz-Morales, UNAM FES Iztacala, Research Grant. 

384.11 S. Nayar, Supported by NIH grant MH083310 to JJ and PC, 


384.12 P.A. Callahan, NIH grant HD 46479-01A1 to JJ and PC, 


384.13 M. Seshadri, NIH grant HD 46479-01A1 to JJ and PC, 

Research Grant; Miami University DUOS grant to MS and KM, 

Other Research Support. 

384.14 M.R. Gonzalez Lopez, FES-Iztacala UNAM, Employment; 

N.L. García-Saldívar, FES-Iztacala-UNAM, Employment; 

G. Castillo-Roberto, FES-Iztacala UNAM, Employment; 

R. Domínguez, UNAM FES-Zaragoza, Research Grant; J. 

Monroy-Moreno, UNAM FES-Zaragoza, Employment; S. 

Cruz-Morales, UNAM FES-Iztacala, Research Grant. 

386.4 M. Bowers, univeristy of Maryland School of Medicine, 

Employment; M.M. McCarthy, University of Maryland, School 

of Medicine, Employment. 

386.21 W. Pratchayasakul, Thailand Research Fund, Research 

Grant; N. Chattipakorn, Thailand Research Fund, Research 

Grant; S. Chattipakorn, Thailand Research Fund, Research 

Grant. 

387.4 S.L. harkey, NSF CAREER 0953106, Research Grant; B.J. 

Aragona, NSF CAREER 0953106, Research Grant. 

387.5 J.B. Price, ETSU Major RDC Grant, Research Grant; NSF 

GK-12 Fellowship, Other Research Support. 

389.16 D.C. Eikenburg, NARSAD Independ. Invest. Award, 


391.2 J. Kennedy, National Institute of Child Health and Human 

Development, Research Grant; A. Dimitropoulos, National 

Institute of Child Health and Human Development, Research 

Grant. 

392.4 A. Klejman, Nencki Institute of Experimental Biology, 

Warsaw, Poland, Employment. 


ABSTRACT 


392.10 K. hasegawa, Grant-in-Aid for Scientific Research, Research 

Grant. 

392.21 E.M. Girault, TIPharma T2-105, Research Grant. 

392.23 T. Sartorius, Deutsche Diabetesgesellschaft, Research 

Grant; A.M. hennige, Deutsche Forschungsgemeinschaft, 


393.5 J. Shi, Patent pending, Ownership Interest; J. Wielaard, 

Patent pending, Ownership Interest; R. Smith, Patent 

pending, Ownership Interest; P. Sajda, Patent pending, 


393.6 W.C. De Souza, University of Brasilia, Research Grant; 

R.L. Leonardo, University of Brasilia, Research Grant; 

f.M. Da Silva, University of Brasilia, Research Grant; J.G. 

Guimaraes, University of Brasilia, Research Grant; R.V.C. 

Magalhaes, University of Brasilia - CNPq, Research Grant. 

393.9 B. Awasthi, Macquarie University Postgraduate Research 

Grant, Other Research Support; J. friedman, Macquarie 

University, Employment; M.A. Williams, Macquarie Centre 

for Cognitive Science,Macquarie University, Employment; 

Australian Research Council Fellowship Schemes 

DP0984919, Research Grant. 

393.11 J.O. Touryan, Science Applications International Corporation, 

Employment. 

393.26 D.S. Schwarzkopf, Wellcome Trust Centre for Neuroimaging, 

University College London, 12 Queen Square, Employment; 

Wellcome Trust, Research Grant; C. Song, University College 

London, Employment; G. Rees, Wellcome Trust Centre for 

Neuroimaging, University College London, 12 Queen Square, 

Employment; Wellcome Trust, Research Grant. 

394.8 Y. Tsushima, JSPS, Employment; JSPS, Research Grant; 

K. Shibata, Boston University, Employment; K. Nakayama, 

Harvard University, Employment; NIH NEI EY013602, 


394.15 D. Burr, ERC, Research Grant. 

395.4 A.L. fenney, PGS-D NSERC, Research Grant; Alzheimer 

Society of Hamilton/Halton, Other Research Support; T.D. 

Lee, NSERC, Research Grant. 

395.9 h. Goh, Singapore Physiotherapy Association, Research 

Grant; North American Socieity for the Psychology of Sport 

and Physical Activity, Research Grant. 

395.14 K. Amemiya, JSPS Research Fellow, Research Grant; S. 

Kojima, Keio GCOE, Research Grant. 

396.3 J.B. Brewer, General Electric Medical Foundation, Research 

Grant; Janssen Alzheimer Immunotherapy, Research Grant. 

396.4 J.B. Brewer, General Electric Medical Foundation, Research 

Grant; Janssen Alzheimer Immunotherapy, Research Grant. 

396.11 J.L. Barredo, Brown University, Employment; NINDS R01 

NS065046, Research Grant; D. Badre, Brown University, 

Employment; NINDS R01 NS065046, Research Grant. 

398.2 D. Kumaran, Wellcome Trust UK, Research Grant. 

399.2 h. Tanaka, Hitachi Co. Ltd., Employment; T. Katura, Hitachi 

Co. Ltd., Employment. 

399.10 E. Clarke, GMU, Employment; A. Andrews, GMU, 

Employment; T. Espeseth, University of Oslo, Employment; 

R. Parasuraman, GMU, Employment; P. Greenwood, GMU, 

Employment. 

400.5 M. Grossman, NIH AG17586, AG15116, NS44266, NS53488, 

Research Grant; Allon Therapeutics, Forest Laboratories, 

Pfizer Pharmaceuticals, Consultant/Advisory Board. 

400.8 S. Obayashi, Grant-in-Aid for Scientific Research (C), 


402.4 J.J. lavaur, Fondation Jérôme Lejeune, Research Grant. 

403.2 T. Robbins, GlaxoSmithKline, Research Grant; E. Lilly 

Inc., Research Grant; Springer Verlag, Speakers Bureau/ 


ABSTRACT 


Honoraria; Cambridge Cognition, Ownership Interest; Pfizer, 

Consultant/Advisory Board; Cambridge Cognition, Consultant/ 

Advisory Board; E. Lilly Inc., Consultant/Advisory Board; 

Lundbeck, Consultant/Advisory Board; Roche, Consultant/ 

Advisory Board; Allon Therapeutics, Consultant/Advisory 

Board; Pangenics, Consultant/Advisory Board. 

403.6 M. Grossman, Forest Labs, Consultant/Advisory Board; 

Allon Therapeutics, Consultant/Advisory Board; Pfizer 

Pharmaceuticals, Consultant/Advisory Board. 

405.10 E.A. Morales: CONACyT 51028, PAPIIT 25651021; Research 

Grant. 

405.13 G. Zhang, NIH, Research Grant; R.G. Cook, NSF, Research 

Grant; A.I. Geller, NIH, Research Grant; equity in Alkermes 

Inc., Ownership Interest. 

405.15 h. Emoto, Dainippon Sumitomo Pharma Co., Ltd., 

Employment; h. Nishikawa, Dainippon Sumitomo Pharma 

Co., Ltd., Employment; T. horisawa, Dainippon Sumitomo 

Pharma Co., Ltd., Employment; S. Toma, Dainippon 

Sumitomo Pharma Co., Ltd., Employment; M. Goto, 

Dainippon Sumitomo Pharma Co., Ltd., Employment; T. 

Murai, Dainippon Sumitomo Pharma Co., Ltd., Employment; 

K. Ikeda, Dainippon Sumitomo Pharma Co., Ltd., 

Employment; T. Ishiyama, Dainippon Sumitomo Pharma Co., 

Ltd., Employment; M. Taiji, Dainippon Sumitomo Pharma Co., 

Ltd., Employment. 

405.24 M. Mohajeri, DSM Nutritional Products Ltd., Employment; A. 

Wyss, DSM Nutritional Products Ltd., Employment; J. Piussi, 

DSM Nutritional Products Ltd., Employment; h. Rieger, DSM 

Nutritional Products Ltd., Employment; N. Seifert, DSM 

Nutritional Products Ltd., Employment; R. Goralczyk, DSM 

Nutritional Products Ltd., Employment; A.A. Mechan, DSM 

Nutritional Products Ltd., Employment. 

405.26 J. Rusche, Repligen Corporation, Employment; S. Jones, 

Repligen Corporation, Employment. 

405.27 A. Chiang, The Excellent Researcher Project from the 

National Science Council in Taiwan, Research Grant. 

406.1 Y. Yeong shin: Brain Korea 21 Project for Medical Sciences; 


406.2 R. Kim, Scientific Research on Priority Areas- Molecular 

Brain Science- (22022039) from MEXT of Japan and CREST, 

JST, Japan., Research Grant; S. Kida, Scientific Research 

on Priority Areas- Molecular Brain Science- (22022039) from 

MEXT of Japan and CREST, JST, Japan., Research Grant. 

406.6 h. fukushima, Scientific Research on Priority Areas- 

Molecular Brain Science- (22022039) from MEXT of Japan 

and CREST, JST, Japan., Research Grant; S. Kida, Scientific 

Research on Priority Areas- Molecular Brain Science- 

(22022039) from MEXT of Japan and CREST, JST, Japan., 


406.24 T. Dittgen, Sygnis Bioscience GmbH & Co. KG, Employment; 

C. Plaas, Sygnis Bioscience GmbH & Co. KG, Employment; 

E. handwerker, Sygnis Bioscience GmbH & Co. KG, 

Employment; C. Pitzer, Sygnis Bioscience GmbH & Co. KG, 

Employment; R. Spoelgen, Sygnis Bioscience GmbH & Co. 

KG, Employment; f. Kirsch, Sygnis Bioscience GmbH & Co. 

KG, Employment; O. Wafzig, Sygnis Bioscience GmbH & 

Co. KG, Employment; K. Nikolich, Amnestix Incorporated, 

Employment; A. Schneider, Sygnis Bioscience GmbH & Co. 

KG, Employment. 

407.11 L.A. Newman, Neuroscience Program, Employment; NIH 

AG07648, Research Grant; NIH DA024129, Research 

Grant; NIH Training Grant HD007333, Research Grant; 

Alzheimer’s Association, Other Research Support; P.E. 

Gold, Neuroscience Program, Employment; Department 

of Psychiatry, Employment; Department of Integrative 

and Molecular Biology, Employment; Department of 

Bioengineering, Employment; Institute for Genomic Biology,

ABSTRACT 


Employment; College of Medicine, Employment; NIH 

AG07648, Research Grant; NIH DA024129, Research Grant; 

Alzheimer’s Association, Other Research Support. 

407.16 P.E. Gold, Alzheimer’s Association, Research Grant; NIH 

AG07648 and DA024129, NSF IOS 08-43175, Research 

Grant. 

409.1 K. McKernan, ABI, Foster City, CA, Employment. 

409.2 A.V. Shevelkin, RFFI grant # 08-04-01730, Research Grant. 

409.7 R. Calin-Jageman, DOE Grant, DE-FG02-08CH11516, 

Research Grant; SOMAS Award, Research Grant; B. 

McBride, SOMAS Award, Other Research Support; I. Calin- 

Jageman, DOE Grant, DE-FG02-08CH11516, Research 

Grant. 

410.8 B. froeliger, Duke University Medical Center, Employment; 

NIDA 1R03DA026536-01, Research Grant. 

411.6 B.G. Cooper, RCAF 60548, Research Grant. 

412.3 K. Deisseroth, McKnight, NIMH, NIDA, NINDS, NIH Pioneer 

Award, Research Grant. 

413.8 B. Kundu, University of Wisconsin, Madison, Employment; 

J.S. Johnson, University of Wisconsin, Madison, 

Employment; NIH NH088115, Research Grant; B.R. Postle, 

University of Wisconsin, Madison, Employment; NIH 

NH064498, Research Grant. 

413.14 K. Meier, St. Jude Medical, Research Grant. 

413.15 L. Kornet, Medtronic, Employment; R. Cornelussen, 

Medtronic, Employment; h.P.J. Buschman, Medtronic, 

Employment. 

413.16 M. Jensen, Sophion Bioscience, Employment; C. Mathes, 

Sophion Bioscience, Employment; R. Schrøder, Sophion 

Bioscience, Employment; h.L. Olsen, Sophion Bioscience, 

Employment; R.B. Jacobsen, Sophion Bioscience, 

Employment; J. Webber, Sophion Bioscience, Employment; 

S. friis, Sophion Bioscience, Employment; D. Nielsen, 

Sophion Bioscience, Employment; M.T. Christensen, 

Sophion Bioscience, Employment; M. Sunesen, Sophion 

Bioscience, Employment. 

414.12 A. Chou, retired, Other. 

414.13 S. Park, NAP of Korea Research Council of Fundamental 

Science & Technology P90015, Research Grant; D. Kim, 

NAP of Korea Research Council of Fundamental Science & 

Technology P90015, Research Grant; J. Lee, NAP of Korea 

Research Council of Fundamental Science & Technology 

P90015, Research Grant; D. Lee, NAP of Korea Research 

Council of Fundamental Science & Technology P90015, 

Research Grant; T. Ko, NAP of Korea Research Council of 

Fundamental Science & Technology P90015, Research Grant. 

416.5 f.h. Gage, sanofi-aventis, Research Grant; Mars, Research 

Grant; IPSEN, Research Grant; Brain Cells Inc, Consultant/ 

Advisory Board; StemCells Inc, Consultant/Advisory Board; 

Ceregene, Consultant/Advisory Board. 

417.3 f. Cervero, Unrestricted research grant from AstraZeneca, 

B. Research Grant (principal investigator, collaborator or 

consultant and pending grants as well as grants already 

received); Receipt of drugs from AstraZeneca, C. Other 

Research Support (receipt of drugs, supplies, equipment 

or other in-kind support); Consultant for AstraZeneca, F. 

Consultant/Advisory Board; Spouse is an employee of 

AstraZeneca Research and Development, Other. 

420.4 R. Kozak, Pfizer, A. Employment (full or part-time). 

420.6 C.M. Thiel, the placebo gum was provided by Pfizer, Other. 

424.3 E.G. Stopa, Merck & Co., Inc., Employment; Merck & Co., 

Inc., Other Research Support; E.V. Nikonova, Merck & Co., 

Inc., Employment; Merck & Co., Inc., Other Research Support; 

A.A. Podtelezhnikov, Merck & Co., Inc., Employment; Merck 

& Co., Inc., Other Research Support; K.Q. Tanis, Merck & 

ABSTRACT 


Co., Inc., Employment; Merck & Co., Inc., Other Research 

Support; E.M. finney, Merck & Co., Inc., Employment; Merck 

& Co., Inc., Other Research Support; D.J. Stone, Merck & 

Co., Inc., Employment; Merck & Co., Inc., Other Research 

Support; L.M. Camargo, Merck & Co., Inc., Employment; 

Merck & Co., Inc., Other Research Support; L. Parker, Merck 

& Co., Inc., Employment; Merck & Co., Inc., Other Research 

Support; A. Verma, Merck & Co., Inc., Employment; Merck & 

Co., Inc., Other Research Support. 

424.4 h. Ge, Proteostasis Therapeutics Inc, Employment; L. 

Wang, Proteostasis Therapeutics Inc, Employment; Y. Zhu, 

Proteostasis Therapeutics Inc, Employment; K. Bailey, 

Proteostasis Therapeutics Inc, Employment; f. Useche, 

Proteostasis Therapeutics Inc, Employment; W. Balch, 

Proteostasis Therapeutics Inc, Consultant/Advisory Board; 

A. Dillin, Proteostasis Therapeutics Inc, Consultant/ 

Advisory Board; R. Morimoto, Proteostasis Therapeutics 

Inc, Consultant/Advisory Board; W. Newman, Proteostasis 

Therapeutics Inc, Consultant/Advisory Board; P. Reinhart, 

Proteostasis Therapeutics Inc, Employment. 

424.5 D.K. Lahiri, NIH, Research Grant. 

425.1 M.G. Tansey, ex-employee of Xencor Inc., Employment. 

426.3 J.P. Pandey, University of South Carolina, Employment; 

1RO1NS056314, Research Grant. 

428.1 M.A. Smith, Medivation, Speakers Bureau/Honoraria; Pfizer, 

Speakers Bureau/Honoraria; Neuropharm, Ownership 

Interest; Neurotez, Ownership Interest; Pancea, Ownership 

Interest; Voyager, Ownership Interest; Anavex, Consultant/ 

Advisory Board; Medivation, Consultant/Advisory Board; 

Neurotez, Consultant/Advisory Board; Aria Neurosciences, 

Consultant/Advisory Board; G. Perry, Neurotez, Ownership 

Interest; Takeda, Consultant/Advisory Board; X. Zhu, 

Medivation, Consultant/Advisory Board. 

430.2 E.C. Peters, Genomics Institute of the Novartis Research 

Foundation, Employment. 

430.3 M.M. Moran, Hydra Biosciences Full-time, Employment; 

J.A. Chong, Hydra Biosciences Full-time, Employment; S. 

Murphy, Hydra Biosciences Full-time, Employment; N.J. 

hayward, Hydra Biosciences Full-time, Employment; N. 

Deering, Hydra Biosciences Full-time, Employment; M. 

D’Amours, Hydra Biosciences Full-time, Employment; C.A. 

Cook, Hydra Biosciences Full-time, Employment; C.M. 

fanger, Hydra Biosciences Full-time, Employment; C.J. 

Woolf, Hydra Biosciences, Consultant/Advisory Board; D. del 

Camino, Hydra Biosciences Full-time, Employment. 

431.9 A. Garakani, Reify Corporation, Ownership Interest. 

434.6 L.S. Bleicher, BrainCells Inc., Employment; C. Barlow, 

BrainCells Inc., Employment; T.A. Carter, BrainCells Inc., 

Employment; A.R. Dearie, BrainCells Inc., Employment; K. 

Eum, BrainCells Inc., Employment; B.T. franchini, BrainCells 

Inc., Employment; E.K. hofer, BrainCells Inc., Employment; 

D.h. Lee, BrainCells Inc., Employment; K.I. Lorrain, 

BrainCells Inc., Employment; J.C. Pires, BrainCells Inc., 

Employment; J.J. Rodriguez, BrainCells Inc., Employment; 

M.D. Saxe, BrainCells Inc., Employment; B.S. Stoveken, 

BrainCells Inc., Employment; P.C. Wedel, BrainCells Inc., 

Employment. 

435.1 J. Zhang, Northwester University, Employment; NINDS RO1 

NS047191, Searle Scholars,Sontag Foundation Distinguished 

Scientist Award, March of Dimes Research Grant, Research 

Grant. 

436.13 h. Kuhn, Vetenskaprådet, Research Grant; 

Strokeriksförbundet, Research Grant; Rune och Ulla Amlövs 

stiftelse, Research Grant. 

437.21 M.A. hayashi, Unifesp, Employment; FAPESP, CNPq, 

Research Grant; J.R. Guerreiro, FAPESP, Employment; E. 

Charych, Pfizer Global R&D, Employment; A. Kamiya, NIH, 


ABSTRACT 


Stanley, NARSAD, CHDI, HighQ, S-R foundation, Research 

Grant; R.L. Barbosa, FAPESP, Employment; FAPESP, 

Research Grant; M.f. Machado, FAPESP, Employment; V. 

Oliveira, Unifesp, Employment; FAPESP, CNPq, Research 

Grant; A. Sawa, Johns Hopkins University School of 

Medicine, Employment; NIH, Stanley, NARSAD, CHDI, 

HighQ, S-R foundation, Research Grant; A.C.M. Camargo, 

FAPESP, Research Grant; N.J. Brandon, Pfizer Global R&D, 

Employment. 

437.27 A. Takano, Japan Society for the Promotion of Science, 


438.19 S.E. Cifelli, NIH NS37560, Research Grant; NMSS 

RG4015A2, Research Grant. 

441.5 D.h. Nichols, COBRE/NIH, Research Grant. 

441.8 M. Gonzalez-Del-Pliego Olivares, Theacher and investigator, 

Employment; Supported by DGAPA IN206007, Research 

Grant. 

443.9 D. Wehrhahn, Eppendorf, Employment. 

444.4 T.R. Jinka, NS041069-06 (National Institute of Neurological 

Disorders and Stroke, National Institute of Mental Health), US 

Army Research Office (W911NF- 05-1-0280), and Institute of 

Arctic Biology, Research Grant; Z.A. Carlson, USAMRMC 

05178001, Flint Hills undergraduate research, Research 

Grant; J.T. Moore, USAMRMC 05178001, Research Grant; 

K.L. Drew, NS041069-06 (National Institute of Neurological 

Disorders and Stroke, National Institute of Mental Health), 

US Army Research Office (W911NF- 05-1-0280), USAMRMC 

05178001, Research Grant. 

444.7 C.J. Langmead, Heptares Therapeutics, Employment. 

445.12 C. Lien, NSC and NHRI, Taiwan, Research Grant; J. Weng, 

NSC and NHRI, Taiwan, Research Grant. 

448.8 S. Gomes Da Silva, CAPES, Research Grant; B.h.S. Araujo, 

FAPESP, Research Grant; A.C. Cossa, CNPq, Research 

Grant; f.A. Scorza, FAPESP, INNT and ClnAPCe, Research 

Grant; E.A. Cavalheiro, FAPESP, INNT and ClnAPCe, 

Research Grant; M. Naffah-Mazzacoratti, FAPESP, INNT 

and ClnAPCe, Research Grant; R.M. Arida, FAPESP, INNT 

and ClnAPCe, Research Grant. 

448.10 M.B. Kozhemyakin, University Central Del Caribe, 

Employment; NIH R01 MH061059, Research Grant; U54 

NS039408, Other Research Support; Maxim Kozhemyakin, 


448.17 T.A. Schikorski, Universidad Central del Caribe, 

Employment; U54 NS039408, NS0263208, Research Grant. 

449.21 T. Indersmitten, NIMH grant # MH609197, Research Grant. 

450.17 W. Spain, VA Puget Sound Health Care System, Employment. 

450.18 E. Galarraga, DGAPA-UNAM IN206010, IN205610 ; 

CONACyT 98004 and IMPULSA-UNAM, Research Grant. 

452.13 P.J. Lombroso, NIH, Research Grant. 

454.1 M.V. Sanchez-Vives, MICINN, Research Grant; N. Parga, 

MICINN, Research Grant. 

454.6 J. Wu, Women’s Board Foundation, Barrow Neurological 

Institute, Other Research Support. 

454.7 D.A. Lewis, Currently receives investigator-initiated research 

support from the BMS Foundation, Bristol-Myers Squibb, 

Curridium Ltd and Pfizer and in 2007-2009 served as a 

consultant to AstraZeneca, BioLine RX, B, Consultant/ 

Advisory Board 

456.1 S.S. Sisodia, Nociris, Inc., Consultant/Advisory Board; Eisai 

Research Labs, Inc., Consultant/Advisory Board. 

456.10 K. heese, This research was supported by the Institute of 

Advanced Studies, Nanyang Technological University, 60 

Nanyang View, Singapore 639673, Research Grant; M. 

Mishra, This research was supported by the Institute of 


ABSTRACT 


Advanced Studies, Nanyang Technological University, 60 

Nanyang View, Singapore 639673, Research Grant. 

456.17 M.L. hendrickson, Mithridion, Inc., Employment; Mithridion, 

Inc., Ownership Interest; M.L. Verdone, Mithridion, Inc., 

Employment; Mithridion, Inc., Ownership Interest; J.G. 

farnham, Mithridion, Inc., Employment; Mithridion, Inc., 

Ownership Interest; R.R. Copp, Mithridion, Inc., Employment; 

Mithridion, Inc., Ownership Interest; T.M. Twose, Mithridion, 

Inc., Employment; Mithridion, Inc., Ownership Interest. 

457.3 G. Wu, Merck and Company, Employment; R. Miller, 

Merck and Company, Employment; J. Marcus, Merck and 

Company, Employment; P. Szczerba, Merck and Company, 

Employment; L. Gold, Merck and Company, Employment; J. 

Renger, Merck and Company, Employment; M.J. Savage, 

Merck and Company, Employment. 

457.8 A.h. Mohammed, EU-FP 6 grant IntelliMaze, Research 

Grant. 

457.12 R.E. Brown, NSERC, Research Grant; Alzheimer’s 

Association, Research Grant. 

458.1 Y.T. Chen, Dart Neuroscience LLC, Employment; T. Tully, 

Dart Neuroscience LLC, Employment. 

458.2 J.R. fernandez, Signum Biosciences, Employment; X. 

feng, Signum Biosciences, Employment; M. Voronkov, 

Signum Biosciences, Employment; S.P. Braithwaite, Signum 

Biosciences, Employment; J.B. Stock, Signum Biosciences, 

Ownership Interest; M.M. Mouradian, Signum Biosciences, 


458.7 M. Bergeron, Elan Pharmaceuticals, Employment; Elan 

Pharmaceuticals, Ownership Interest; R. Motter, Elan 

Pharmaceuticals, Employment; Elan Pharmaceuticals, 

Ownership Interest; f. San Pablo, Elan Pharmaceuticals, 

Employment; Elan Pharmaceuticals, Ownership Interest; 

P. Tanaka, Elan Pharmaceuticals, Employment; Elan 

Pharmaceuticals, Ownership Interest; D. Kholodenko, 

Elan Pharmaceuticals, Employment; Elan Pharmaceuticals, 

Ownership Interest; D. fauss, Elan Pharmaceuticals, 


E. Goldbach, Elan Pharmaceuticals, Employment; Elan 

Pharmaceuticals, Ownership Interest; h. Zhang, Elan 

Pharmaceuticals, Employment; Elan Pharmaceuticals, 

Ownership Interest; h.L. Sham, Elan Pharmaceuticals, 


J.P. Anderson, Elan Pharmaceuticals, Employment; Elan 

Pharmaceuticals, Ownership Interest. 

458.10 G. Bitan, Clear Therapeutics, Inc., Ownership Interest; S. 

Sinha, Co-inventor, Other; M. Chesselet, Clear Therapeutics, 

Inc., Consultant/Advisory Board; T. Schrader, Co-inventor, 

Ownership Interest; f. Klärner, Co-inventor, Ownership 

Interest. 

458.21 M.M. Mouradian, Signum Biosciences, Research Grant; X. 

feng, Signum Biosciences, Employment; J.R. fernandez, 

Signum Biosciences, Employment; M. Voronkov, Signum 

Biosciences, Employment; S.P. Braithwaite, Signum 

Biosciences, Employment; J.B. Stock, Signum Biosciences, 


458.22 M. Voronkov, Signum Biosciences, Employment; Y. Chao, 

Signum Biosciences, Employment; X. feng, Signum 

Biosciences, Employment; J.R. fernandez, Signum 

Biosciences, Employment; M. Stock, Signum Biosciences, 

Employment; J.B. Stock, Signum Biosciences, Ownership 

Interest; S.P. Braithwaite, Signum Biosciences, Employment. 

459.6 M. Saji, Kitasato University School of Allied Health Sciences 

(Grand-in-Aid for Research Project, No.2008-1021), Research 

Grant. 

459.13 C.R. Butson: Intelect Medical; Ownership Interest, Intelect 

Medical; Consultant/Advisory Board.

ABSTRACT 


459.24 A.M. Noecker, IntElect Medical Inc., Ownership Interest; C.C. 

McIntyre, IntElect Medical Inc., Ownership Interest. 

460.4 B. Venegas Meneses, VIEP/BUAP-Hc 2008-2010, 

Laboratory of Neuropharmacology, Other Research Support. 

460.17 L.h. Bradley, 3 Patents Pending, Ownership Interest; J.D. 

Glass, 3 Patents Pending, Ownership Interest; D.M. Gash, 

3 Patents Pending, Ownership Interest; G.A. Gerhardt, 3 

Patents Pending, Ownership Interest. 

461.3 P.P. Pungaliya, Pfizer, Inc., Employment; Michael J Fox 

Foundation, Research Grant; Y. Bai, Pfizer, Inc., Employment; 

K. Lipinski, Pfizer, Inc., Employment; V. Anand, Pfizer, 

Inc., Employment; Michael J Fox Foundation, Research 

Grant; E. Brown, Pfizer, Inc., Employment; B. Bates, Pfizer, 

Inc., Employment; P. Reinhart, Pfizer, Inc., Employment; W. 

hirst, Pfizer, Inc., Employment; S. Braithwaite, Pfizer, Inc., 

Employment. 

461.19 M.J. O’Neill: Lilly UK; Employment. 

461.24 Y. huang, NHMRC project grant 510186, Employment; 

NHMRC project grant 510186, Research Grant; W.P. Gai, 

NHMRC project grant 510186, Research Grant; G. halliday, 

NHMRC project grant 510186, Research Grant. 

463.19 E. Arnold, Pfizer Inc., Employment; S.M. O’Neill, Pfizer 

Inc., Employment; h. Samaroo, Pfizer Inc., Employment; 

D. hannah, Pfizer Inc., Employment; S. Shetty, Pfizer 

Inc., Other Research Support; A. Tiwari, Pfizer Inc., Other 

Research Support; V. Vaidya, Pfizer Inc., Other Research 

Support; B. Campbell, Pfizer Inc., Employment; R.h. Ring, 

Pfizer Inc., Employment; D.T. Stephenson, Pfizer Inc., 

Employment. 

464.3 G.A. Gerhardt, Quanteon, LLC, Ownership Interest. 

464.7 R. Di Maio, RiMED Foundation, Palermo, Italy, Research 

Grant. 

464.10 L.K. friedman, Partnership for Pediatric Epilepsy, 589045 

(to LKF), Research Grant; D. Spray, NIH NS041282 (to DS), 


464.15 D.X. Zhang, NIH Grant:NS25605, Research Grant; E.h. 

Bertram, NIH Grant:NS25605, Research Grant. 

464.24 K. Riazi, AHFMR, Savoy Foundation, Other Research 

Support. 

465.4 J.A. Gonzalez-Barrios, Neuroinmunogenomic Research 

Laboratory, HR 1o de Octubre, ISSSTE, Employment; FOSIS- 

COACYT-2007- 69678, Research Grant. 

465.19 A.N. hoofnagle, Waters, Other Research Support; Thermo 

Fisher, Consultant/Advisory Board. 

466.2 D.G. Stein, DG Stein is entitled to royalties from products of 

BHR Pharmaceuticals Ltd related to the research described in 

this presentation and may receive research funding from BHR 

Pharmaceuticals, which is d, Ownership Interest. 

467.29 h.T. Cline, Dart NeuroScience, LLC, Other Research Support. 

468.1 M.G. fehlings, CHIR, Research Grant. 

471.4 J.h. Kogan, Astellas Pharmaceuticals, Employment; 

R. Shin, Astellas Pharmaceuticals, Employment; N.M. 

Walton, Astellas Pharmaceuticals, Employment; C.L. 

heusner, Astellas Pharmaceuticals, Employment; Q. 

Chen, Astellas Pharmaceuticals, Employment; K. Tajinda, 

Astellas Pharmaceuticals, Employment; J.N. Masters, 

Astellas Pharmaceuticals, Employment; K. Tamura, Astellas 

Pharmaceuticals, Employment; M. Matsumoto, Astellas 

Pharmaceuticals, Employment. 

471.8 Q. Chen, Astellas Research Institute of America LLC, 

Employment; J.h. Kogan, Astellas Research Institute of 

America LLC, Employment; N.M. Walton, Astellas Research 

Institute of America LLC, Employment; R. Shin, Astellas 

Research Institute of America LLC, Employment; C.L. 

heusner, Astellas Research Institute of America LLC, 

ABSTRACT 


Employment; K. Tajinda, Astellas Research Institute of 

America LLC, Employment; J.N. Masters, Astellas Research 

Institute of America LLC, Employment; K. Tamura, Astellas 

Research Institute of America LLC, Employment; M. 

Matsumoto, Astellas Research Institute of America LLC, 

Employment. 

471.21 W. Li, NIMH, Research Grant; 973 Program, Research 

Grant; NARSAD, Other Research Support; A.J. Silva, NIMH, 


472.1 T.P. Roberts, 5R01DC008871-03, Research Grant; 

S.J. Siegel, 5R01DA023210-03, Research Grant; 

2R01MH074672-03A1, Research Grant; NuPathe, 


472.2 A.W. Schmidt, employee of Pfizer Inc, Employment; M.A. 

Vanase-frawley, Pfizer Inc, Employment; J. McLaughlin, 

currently employed by Torrey Pines, Employment; work 

funded by Pfizer Inc, Other Research Support; P. Verhoest, 

Pfizer Inc, Employment; S. Grimwood, Pfizer Inc, 

Employment. 

472.5 L.K. Jacobsen, Pfizer, Employment; A. Banerjee, Pfizer, 

Employment; W. Byon, Pfizer, Employment; T.J. McCarthy, 

Pfizer, Employment; S. Grimwood, Pfizer, Employment; L. 

Badura, Pfizer, Employment. 

472.7 C.A. Strick, Pfizer Inc, Employment; B. Campbell, Pfizer 

Inc, Employment; M.M. hayward, Pfizer Inc, Employment; 

W.E. horner, Pfizer Inc, Employment; L.C. James, Pfizer 

Inc, Employment; D. McGinnis, Pfizer Inc, Employment; 

P.A. Seymour, Pfizer Inc, Employment; K.J. Stutzman- 

Engwall, Pfizer Inc, Employment; P.R. Verhoest, Pfizer 

Inc, Employment; J.S. Culp, Pfizer Inc, Employment; P. 

Loulakis, Pfizer Inc, Employment; S.J. hawrylik, Pfizer 

Inc, Employment; L.E. Zawadzke, Pfizer Inc, Employment; 

M.A. Salafia, Pfizer Inc, Employment; B. Sneed, Pfizer 

Inc, Employment; h. Zhao, Pfizer Inc, Employment; J.J. 

Valentine, Pfizer Inc, Employment; h. Wang, Pfizer Inc, 

Employment; K.R. fonseca, Pfizer Inc, Employment; N.C. 

Stratman, Pfizer Inc, Employment. 

472.9 f. Bian, Pfizer, Inc., Employment; D. hannah, Pfizer, Inc., 

Employment; B. Campbell, Pfizer, Inc., Employment. 

472.10 R.M. hinchliffe, Merck & Co, Inc, Employment; R. 

Pachmerhiwala, Merck & Co, Inc, Employment; A.Y. 

Kornilova, Merck & Co, Inc, Employment; h.A. Rajapakse, 

Merck & Co, Inc, Employment; M.W. Embrey, Merck & Co, 

Inc, Employment; S. Rittle, Merck & Co, Inc, Employment; 

J.A. McCauley, Merck & Co, Inc, Employment; I.J. Reynolds, 

Merck & Co, Inc, Employment; W.J. Ray, Merck & Co, Inc, 

Employment; S.M. Smith, Merck Research Laboratories, 

Employment. 

472.15 B. Steiniger Brach, H. Lundbeck A/S, Employment; L. 

Tøttrup Brennum, H. undbeck A/S, Employment. 

472.16 D.S. Chapin, Pfizer Inc., Employment; B. Campbell, Pfizer 

Inc., Employment; C. Strick, Pfizer Inc., Employment; R. 

Kozak, Pfizer Inc., Employment. 

472.18 A. Abbott, Pfizer Inc, Other Research Support; B.M. 

Roberts, Pfizer Inc, Other Research Support; L. Turner, 

Pfizer Inc, Other Research Support; D.W. Campbell, Pfizer 

Inc, Other Research Support; C.L. Schaffer, Pfizer Inc, 

Employment; B.M. Campbell, Pfizer Inc, Employment; P.A. 

Seymour, Pfizer Inc, Employment; C.J. Schmidt, Pfizer 

Inc, Employment; G.V. Williams, Pfizer Inc, Other Research 

Support; S.A. Castner, Pfizer Inc, Other Research Support. 

472.19 C.J. Schmidt, Employee of Pfizer GRD, Employment; P.A. 

Seymour, Employee of Pfizer GRD, Employment. 

472.24 P. Zagouras, Pfizer Inc., Employment; S.G. Des Etages, 

Pfizer Inc., Employment; L.S. hayes, Pfizer Inc., Employment; 

B. Campbell, Pfizer Inc., Employment; L.C. James, Pfizer 

Inc., Employment; C.A. Strick, Pfizer Inc., Employment. 


ABSTRACT 


472.25 D.f. Wong, Avid, Other Research Support; Lilly, Other 

Research Support; NIH, Research Grant; Lundbeck, Other 

Research Support; Johnson and Johnson, Other Research 

Support; Merck, Other Research Support; Otsuka, Other 

Research Support; GE, Other Research Support; Roche, 

Other Research Support; Intracellular, Other Research 

Support; G. Snyder, Intracellulartherapies, Employment; 

J. hendrick, Intracellulartherapies, Employment; 

A. fienberg, Intracellulartherapies, Employment; L. 

Wennogle, Intracellulartherapies, Employment; S. 

Mates, Intracellulartherapies, Employment; K. Vanover, 

Intracellulartherapies, Employment. 

473.19 S.C. Steffensen, NIH R01, Research Grant. 


475.5 S.S. Sanjakdar, NIDA, Research Grant. 

475.10 S. Charntikov, DA023951, Research Grant; DA018114, 

Research Grant; R.A. Bevins, DA023951, Research Grant; 

DA018114, Research Grant. 

475.12 W.h. Berrettini, NIH R01DA025201, Research Grant. 


476.10 A.W. Bruijnzeel, DA023575, Research Grant; NIDA, 


476.12 S. Valera, HiQScreen Sarl, Employment; S. Bertrand, 

HiQScreen Sarl, Employment; h. Rollema, Pfizer Inc, 

Employment; R.S. hurst, Pfizer Inc, Employment; D. 

Bertrand, HiQScreen Sarl, Employment. 

476.28 J. Wang, University of Virginia, Employment. 

477.6 D.V. Zaretsky, DA020484-05, Research Grant; M.V. 

Zaretskaia, DA020484-05, Research Grant; D.E. Rusyniak, 

DA020484-05, Research Grant. 

478.1 D. Wasserman, CIHR, Research Grant; OMHF, Research 

Grant. 

478.7 E.J. Chesler, U01AA13499, U24AA13513, Research Grant; 

The Jackson Laboratory, Other Research Support. 

480.1 N. Li, University of Texas at Austin, Employment; NIH, 

Research Grant; G. Pollak, University of Texas at Austin, 

Employment; NIH, Research Grant. 

480.6 h. Gilbert, Medical Research Council, UK, Research Grant; 

C. Lanting, Medical Research Council, UK, Research Grant; 

K. Krumbholz, Medical Research Council, UK, Research 

Grant. 

480.15 I. fukui, KAKENHI 22700413, Research Grant. 

481.10 S.W. Skorheim, NIH, Other Research Support. 

482.15 Y.J. Sun, University of Southern California, Employment; 

RO1DC008983, Research Grant; R21DC008588, Research 

Grant; Searle Scholar Program, Research Grant; Packard 

Fellowships for Science and Engineering, Research Grant; 

Klingenstein Foundation, Research Grant. 

483.10 R. Laing, University of Washington, Employment; NIH Grant 

EY016045, Research Grant; 74-0478, Research Grant; h. Lu, 

NIH Grant EY016045, Research Grant; 74-0478, Research 

Grant; J. Turecek, NIH Grant EY016045, Research Grant; 

74-0478, Research Grant; J.f. Olavarria, University of 

Washington, Employment; NIH Grant EY016045, Research 

Grant; 74-0478, Research Grant. 

483.16 Y. Meng, Harvard_MIT Health Science and Technology, 

Employment. 

484.1 R.S. Ivanov, Institution of Russian Academy of Sciences 

Institute for Higher Nervous Activity and Neurophysiology 

RAS, Employment; E.E. Minakova, Institution of Russian 

Academy of Sciences Institute for Higher Nervous Activity and 

Neurophysiology RAS, Employment; I.V. Bondar, Institution 

of Russian Academy of Sciences Institute for Higher Nervous 

Activity and Neurophysiology RAS, Employment. 


ABSTRACT 


484.7 K. Kim, Cognitive Neuroscience Program of the Korea 

Ministry of Education, Science and Technology, Research 

Grant. 

484.21 Y. Ikegaya, the Japan Society for Promotion of Science, Nos. 

22680025 and 22650080, Research Grant. 

486.12 Z.C. Thumser, Dept of Veterans Affairs, Research Grant; J.S. 

Stahl, Dept of Veterans Affairs, Research Grant. 

487.12 J.L. Rhudy, American Pain Society Grant, Research Grant. 

488.2 K. Shibuta, Koichi Iwata, Employment. 

488.7 M.L. Oshinsky, Thomas Jefferson University, Employment; 

Endo, Medtronics, Minster Pharm., Research Grant; Merck, 


489.13 J. fox, Cambria Biosciences, Employment; G.E. Stilwell, 

Cambria Biosciences, Employment. 

490.21 N. Shigematsu, KAKENHI (20700320), Research Grant. 

491.2 f. Sotty, Lundbeck, Employment; K. fog, Lundbeck, 

Employment; S.f. Traynelis, NeurOp Inc, Ownership Interest; 

NeurOp Inc, Consultant/Advisory Board. 

491.14 L.A. Bryant, University of Alabama Birmingham, Employment; 

J.K. Roche, University of Alabama Birmingham, Employment; 

R.C. Roberts, University of Alabama Birmingham, 

Employment; NIH MH 60744, Research Grant. 

491.21 S. Uthayathas, Pfizer, Research Grant; C.J. Schmidt, Pfizer 

Global Research and Development, Employment; S.M. 

Papa, Pfizer, Research Grant; f.S. Menniti, cyclicM LLC, 

Employment. 

491.24 A. Leblois: Research Grant; R03DC009686, R01MH066128. 

D.J. Perkel: R03DC009686, R01MH066128. 

492.7 T. Kurayama, Grants-in-Aid for Scientific Research, Research 

Grant; T. Yamaguchi, Grant-in-Aid for JSPS Fellows, 

Research Grant; R. Osu, Strategic Research Program for 

Brain, Research Grant. 

492.8 T. Tomlinson, NIH/NICHHD R01 HD-39311, Research Grant; 

R.L. Sainburg, NIH/NICHHD R01 HD-39311, Research 

Grant. 

492.18 P.L. Van Kan, NIH NS 043317, Research Grant. 

492.23 S.h. Scott, BKIN Technologies, Ownership Interest. 

492.24 S. Akpinar, NIH Grant R01 HD 39311, Research Grant. 

492.26 D.A. Kistemaker, The University of Western Ontario, 

Employment; The Netherlands Organisation for Scientific 

Research (NWO), Research Grant. 


494.12 S.h. Scott, BKiN Technologies, Ownership Interest. 


494.14 M. Bourguignon, FRS-FNRS research convention 3.4611.08 

Belgium, Research Grant; S. Goldman, Brains Back to 

Brussels grant (Brussels, Belgium), Research Grant; ERC 

Advanced Grant #232946, Research Grant; FRS-FNRS 

research convention 3.4611.08 Belgium, Research Grant; V. 

Jousmäki, Brains Back to Brussels grant (Brussels, Belgium), 


494.23 T.J. Ebner, Medtronic, Inc., Other Research Support. 

496.3 M.A. Geyer, MH052885, Research Grant; MH074697, 

Research Grant; VISN 22 Mental Illness Research, Education, 

and Clinical Center, Other Research Support; San Diego 

Instruments, Ownership Interest; V.B. Risbrough, Veterans 

Affairs Center of Excellence for Stress and Mental Health, 


496.9 J.K. Belanoff, Corcept Therapeutics, Employment; E. de 

Kloet, Corcept Therapeutics, Consultant/Advisory Board. 

496.16 C. McCormick, NSERC, Research Grant; J. Menard, 

NSERC, Research Grant. 

497.9 K.L. Tamashiro, NIH HD055030, Research Grant; T.h.

ABSTRACT 


Moran, NIH DK077623, Research Grant. 

497.17 M.J. Owens, NIH, Research Grant; Eli Lilly, Research Grant; 

Lundbeck A/S, Research Grant; Cyberonics, Research 

Grant; Ortho-McNeil Janssen, Research Grant; AstraZeneca, 

Research Grant; Dainippon Sumitomo Pharma, Research 

Grant; H. Lundbeck A/S, Speakers Bureau/Honoraria; H. 

Lundbeck A/S, Consultant/Advisory Board; Patent (US 

7,148,027 B2), Other. 

498.19 S. fargali, NIH Endocrine Training Grant 5T32DK07645, 

RO1 DK071308, Research Grant; APA DPN Predoctoral 

Fellowship, Other Research Support; the Diabetes Action 

Research and Education Foundation;SRS is a NARSAD van 

Ameringen Investigator, Other. 

498.21 C.S. ho, Originus Inc, Employment; NIH MH083420, 

Research Grant; NIH MH086216, Research Grant; NIH 

MH070995, Research Grant; C. Li, NIH MN070995, Research 

Grant; M. Kreuz, NIH MH070995, Research Grant; A.W. 

Avery, Originus Inc., Employment; NIH MH083420, Research 

Grant; NIH MH086216, Research Grant; M.I. Morano, 

Originus Inc, Employment; NIH MH070995, Research Grant; 

NIH MH083420, Research Grant; NIH MH086216, Research 

Grant. 

499.17 G.J. DeMarco, Pfizer Inc., Employment; T.A. Swanson, 

Pfizer Inc., Employment. 

500.3 N. Dale, Sarissa Biomedical Ltd., Other. 

500.10 f. Desarnaud, MH 59839, NS 34004, Research Grant. 

502.12 L. Petitto, University of Toronto, Employment; NIH 

R01HD04582203, Research Grant; NIH R21HD05055802, 

Research Grant; Canadian Foundation for Innovation, 

Research Grant; Ontario Research Fund, Research Grant. 

502.21 V. Prabhakaran, NIH/UL1RR025011, Research Grant; W.H. 

Coulter Translational Partnership in Biomedical Engineering 

Research Grant Fund, Other Research Support. 

503.1 M. Dhamala, Georgia State, Employment; Georgia State B&B 

Grant, Research Grant. 

503.6 D. Wang, NSFC, Research Grant. 

504.5 B.B. Biswal, RC1MH090912-01 NIH NIMH Challenge Grant, 

Research Grant; M.E. Meyerand, RC1MH090912-01 NIH 

NIMH Challenge Grant, Research Grant. 

504.13 J. hardy, Lumos Labs, Employment; Lumos Labs, Ownership 

Interest; M. Scanlon, Lumos Labs, Employment; Lumos Labs, 


505.5 A.M. Balboa-Verduzco, UNAM-DGAPA IN-303209, Research 

Grant; D. Velázquez-López, UNAM- DGAPA IN-303209, 

Research Grant; D. Velazquez-Martinez, UNAM-DAGAPA 

IN-303209, Research Grant. 

505.27 D.M. Eagleman, NIH RO1 NS053960, Research Grant. 

506.16 D.L. Turner, patent on miR-155, Ownership Interest. 

506.17 M. Decker, Abbott Laboratories, Employment; Abbott 

Laboratories, Ownership Interest; M. Sarter, Abbott 

Laboratories, Research Grant; Abbott Laboratories, Other 

Research Support; Abbott Laboratories, Speakers Bureau/ 

Honoraria. 

506.23 K. Ikeda, Dainippon Sumitomo Pharma, Co., Ltd., 

Employment; T. Murai, Dainippon Sumitomo Pharma, Co., 

Ltd., Employment; T. Tsujimura, Dainippon Sumitomo 

Pharma, Co., Ltd., Employment; T. fukuoka, Dainippon 

Sumitomo Pharma, Co., Ltd., Employment; M. Ikejiri, 

Dainippon Sumitomo Pharma, Co., Ltd, Employment; 

K. hoshino, Dainippon Sumitomo Pharma, Co., Ltd., 

Employment; T. Ishiyama, Dainippon Sumitomo Pharma Co., 

Ltd., Employment; J. Kimura, Dainippon Sumitomo Pharma, 

Co., Ltd., Employment; M. Taiji, Dainippon Sumitomo 

Pharma, Co., Ltd., Employment. 

507.3 J.L. Evenden, WiltonLogic LLC, Ownership Interest 

ABSTRACT 


508.10 T.W. Robbins, Eli Lilly, Consultant/Advisory Board 

508.12 M.C. Olmstead, the Natural Sciences and Engineering 

Research Council of Canada (NSERC)., Research Grant. 

508.13 T.W. Robbins, Wellcome Trust, Research Grant; Medical 

Research Council, Research Grant; Pfizer, Research Grant; 

GlaxoSmithKline, Research Grant; Eli Lilly, Research Grant; 

Cambridge Cognition, Consultant/Advisory Board; Pfizer, 

Consultant/Advisory Board; Eli Lilly, Consultant/Advisory 

Board; Roche, Consultant/Advisory Board; Lundbeck, 


509.6 N.A. Jurdak, CNR, Research Grant; R.B. Kanarek*, CNR, 

Research Grant; K.E. D’anci, CNR, Research Grant. 

509.9 S.D. Croll, Work generated by funding from Regeneron 

Pharmaceuticals, Research Grant; Shareholder in Regeron 

Pharmaceuticals, Ownership Interest; Conultant, Regeneron 

Pharmaceuticals, Consultant/Advisory Board. 

509.14 E. Langer, NRSAD, Research Grant. 

509.19 D.C. Beshore, Merck & Co., Inc., Employment. 

511.12 C. Yu, Duke University, Employment; D. fan, Duke University, 

Employment; h. Yin, Duke University, Employment; National 

Institute on Alcohol Abuse and Alcoholism, Research Grant. 

511.17 S.N. haber, Medtronics, Speakers Bureau/Honoraria; Eli 

Lilley, Speakers Bureau/Honoraria. 

511.25 I.M. Reti, rTMS clinical trials funded by Brainsway and 

Neuronetics Inc., Other Research Support. 

514.3 G.E. Jaskiw, Stanley Medical Research Institute, Other 

Research Support; Merck Inc., Speakers Bureau/Honoraria; 

Gerson Lehrman Group, Consultant/Advisory Board. 

514.5 K.E. McCormick, Pfizer Inc., Employment. 

514.8 f.G. Revel, F. Hoffmann-La Roche, Employment; S. 

Obermueller, F. Hoffmann-La Roche, Employment; P. 

Piraino, Paolo Piraino Statistical Consulting, Employment; 

J. Lamerz, F. Hoffmann-La Roche, Employment; T. 

Schindler, F. Hoffmann-La Roche, Employment; h. 

Langen, F. Hoffmann-La Roche, Employment; C. fattinger, 

F. Hoffmann-La Roche, Employment; J.G. Wettstein, 

F. Hoffmann-La Roche, Employment; M.C. hoener, F. 

Hoffmann-La Roche, Employment; G. Dernick, F. Hoffmann- 

La Roche, Employment; G. Walker, F. Hoffmann-La Roche, 

Employment. 

514.11 A. Atkinson: Employment; PerkinElmer. S. Anani: 

PerkinElmer. A. Marcil: PerkinElmer. P. Roby: PerkinElmer. 

S. Parent: PerkinElmer. S. Dahan: PerkinElmer. f. Lipari: 

PerkinElmer. 

515.1 A.I. Geller, NIH, Research Grant; equity in Alkermes Inc., 

Ownership Interest; G. Zhang, NIH, Research Grant. 

515.2 B. Zlokovic, B.V.Z. is the scientific founder of Socratech 

L.L.C., a startup biotechnology, Other. 

515.3 K. Jaanson, Patent application, Ownership Interest; M. 

Sepp, Patent application, Ownership Interest; I. Koppel, 

Patent application, Ownership Interest; T. Timmusk, Patent 

application, Ownership Interest. 

515.16 U. Lakshmipathy, Life Technologies, Employment; R. 

Quintanilla, Life Technologies, Employment; L. Chase, Life 

Technologies, Employment; C. MacArthur, Life Technologies, 

Employment; D.R. Piper, Life Technologies, Employment; M. 

Rao, Life Technologies, Employment. 

515.25 V. Ruiz-Velasco, Patent Pending, Other; L.A. Vozza-Brown, 

Life Technologies Inc, Employment. 

516.3 D. han, Samsung Electronics, Employment. 

516.5 S.O. Ahmad, Richard and Hubert Hanlon Trust, Research 

Grant; Neuroscience Associates, Research Grant; C. Almli, 

Neuroscience Associates, Research Grant. 

516.14 S.V. Alworth, DRVision Technologies LLC, Employment; 


ABSTRACT 


NIMH6R44MH075498, Research Grant; J.S.J. Lee, DRVision 

Technologies LLC, Employment; NIMH6R44MH075498, 

Research Grant; A.W. Dunah, NIMH6R44MH075498, 


516.16 B.D. Robertson, Walter Reed Army Institute of Research, 

Employment. 

516.18 D. Peruzzi, MBF Bioscience, Employment; D. hoppes, MBF 

Bioscience, Employment; P. Angstman, MBF Bioscience, 

Employment; J.R. Glaser, MBF Bioscience, Employment. 

516.19 S. hendricks, MBF Bioscience, Employment; M.J. fay, MBF 

Bioscience, Employment; J.O. Blaisdell, MBF Bioscience, 

Employment; J.h. Sprenger, MBF Bioscience, Employment; 

J.R. Glaser, MBF Bioscience, Employment. 


ABSTRACT 

NUMBER STATEMENT

Notes 

XII Neuroscience 2010

Convention Center Floor Plans 

San Diego Convention Center Floor Plan, Upper Level 

San Diego Convention Center Floor Plan, Mezzanine Level 

Student and Postdoc 

Hospitality Suite 

Featured and 

Special Lectures

Certificate of Attendance 

Express Badge Pick-up 

Food Court 

Headquarters — Logistics and Programming 

Housing Desk 

Lost and Found 

Membership 

NeuroJobs 

Neuroscience Meeting Planner Viewing Room 

Program and Exhibit Guide Pick-up 

Registration 

Sails Message Center 

SfN Information Booth 

Wireless Support 

Infant 

Care 

KiddieCorp 

Child Care 

Press 

Room 

Press 

Conference 

Room 

Press 

Interview 

Room 

SfN Members’ Business Meeting 

Speaker Ready Room 

SfN Executive Meeting Room

San Diego Convention Center Floor Plan, Exhibit Halls 

A 10 

A 9 

A 8 

A 7 

A 6 

A 5 

A 4 

A 3 

A 

A 2 

A 1 

B 14 B 15 

C 19 C 20 

B 13 B 16 

D21 D22 

C 18 C 21 

B 12 

D20 D23 

B 17 

C 17 C 22 

B 11 

D19 D24 

B 18 

C 16 C 23 

D18 D25 

B 10 B 19 

C 15 C 24 

B 9 

D17 D26 

B 20 

C 14 

C 25 

B 8 

D16 D27 

B 21 C 13 C 26 

B 7 

D15 D28 

B 22 C 12 

C 27 

B 6 

D14 D29 

B 23 

C 11 C 28 

D13 

B 5 

D30 

B 24 

C 10 C 29 

D12 D31 

B 

B 4 B 25 

B 3 B 26 

B 2 B 27 

B 1 B 28 

B 

C 9 C 30 

C 8 C 31 

C 7 C 32 

C 6 C 33 

C 5 

C 34 

C 4 

C 35 

C 3 C 36 

C 2 C 37 

C 1 C 38 

C 

C 

ABSTRACT 

LOCATOR 

D11 D32 

D10 D33 

D9 D34 

D8 D35 

D7 D36 

D6 D37 

D5 D38 

D4 D39 

D3 D40 

D2 D41 

D1 D42 

E20 

E33 

E18 E35 

E15 E38 

E14 E39 

E12 E41 

E10 E43 

E9 E44 

E8 E45 

E7 E46 

E6 E47 

E5 E48 

E4 E49 

E3 

E50 

E2 E51 

E1 E52 

ENTRANCE ENTRANCE ENTRANCE 

Neuroscience 2010 — Exhibits and Poster Sessions 

San Diego Convention Center: Halls B-H 

Meeting Dates: Nov. 13–17 

Exhibit Dates: Nov. 14–17 

D 

D 

E25 E28 

E24 E29 

E23 

E30 

E22 

E31 

E21 

E32 

E19 

E17 

E16 

E13 

E11 

E26 E27 

E 

E 

E34 

E36 

E37 

E40 

E42 

F29 F30 

F28 F31 

F27 F32 

F26 F33 

F25 F34 

F24 F35 

F23 F36 

F22 F37 

F21 F38 

F20 F39 

F19 F40 

F18 

F41 

F17 F42 

F16 F43 

F15 F44 

F14 F45 

F13 F46 

F12 F47 

F11 F48 

F10 F49 

F9 F50 

F8 

F51 

F7 

F52 

F6 

F53 

F5 

F54 

F4 F55 

F3 

F56 

F2 F57 

F1 F58 

F 

F 

G29 G30 

G28 G31 

G27 G32 

G26 G33 

G25 G34 

G24 G35 

G23 G36 

G22 G37 

G21 G38 

G20 G39 

G19 

G40 

G18 

G41 

G17 

G42 

G16 

G43 

G15 

G44 

G14 G45 

G13 G46 

G12 G47 

G11 

G48 

G10 

G49 

G9 

G50 

G8 

G51 

G7 

G52 

G6 

G53 

G5 

G54 

G4 G55 

G3 G56 

G2 G57 

G1 G58 

G 

G 

H35 H36 

H34 H37 

H33 H38 

H32 

H39 

H31 H40 

H30 H41 

H29 H42 

H28 H43 

H27 H44 

H26 H45 

H25 

H46 

H24 

H47 

H23 

H48 

H22 

H49 

H21 

H50 

H20 H51 

H19 

H52 

H18 H53 

H17 H54 

H16 H55 

H15 H56 

H14 

H57 

H13 

H58 

H12 

H59 

H11 H60 

H10 

H61 

H9 

H62 

H8 H63 

H7 H64 

H6 H65 

H5 

H66 

H4 H67 

H3 

H68 

H2 H69 

H1 

H70 

H 

H 

Hall H 

I 32 I 33 

I 31 I 34 

I 30 I 35 

I 29 I 36 

I 28 I 37 

I 27 I 38 

I 26 I 39 

I 25 I 40 

I 24 

I 23 

I 22 

I 21 

I 20 

I 19 

I 18 

I 17 

I 16 

I 15 

I 14 

I 13 

I 12 

I 11 

I 10 

I 9 

I 8 

I 7 

I 6 

I 5 

I 4 

I 3 

I 2 

I 1 

Lobby H 

I 

ABSTRACT 

LOCATOR 

I 

130 

128 

122 

120 

118 

116 

114 

112 

100 

136 

134 

NOTE: Hall entrances open at noon on Saturday, Nov. 13 and at 7 a.m. on Sunday, Nov. 14 to Wednesday, Nov. 17 for poster presenter setup. 

Poster sessions are open for all attendees at 1 p.m. on Saturday, Nov. 13 and 8 a.m. on Sunday, Nov. 14 to Wednesday, Nov. 17. 

J10 J11 

J9 J12 

J8 J13 

J7 J14 

J6 J15 

J5 J16 

J4 J17 

J3 J18 

J2 J19 

J1 J 20 

J 

135 

132 133 

129 

119 

113 

107 

105 

103 

101 

236 

206 

234 

232 

228 

Cambridge 

University 

Press 

100 AISLE 

218 

K 10 K 11 

K 9 K 12 

K 8 K 13 

K 7 

K 14 

K 6 K 15 

K 5 K 16 

K 4 K 17 

K 3 K 18 

K 2 K 19 

K 1 K 20 

K 

216 217 

214 215 

212 213 

200 

200 AISLE 

ENTRANCE 

L6 L7 

L5 L8 

L4 L9 

L3 L10 

L2 L11 

L1 L12 

L 

Rogue 

Research, 

Inc. 

203 

201 

235 

231 

229 

223 

221 

330 331 

328 329 

322 323 

320 321 

314 

312 313 

300 AISLE 

307 

305 

337 

335 

333 

315 

ENTRANCE 

M 9 M 10 

M 8 

M 11 

M 7 

M 12 

M 6 M 13 

M 5 

M 14 

M 4 

M 15 

M 3 M 16 

M 2 M 17 

M 1 M 18 

M 

300 301 400 401 

Sutter Instrument 

Company 

402 

436 437 

434 435 

432 433 

430 

428 

422 423 

420 421 

414 

412 

Coat and 

Luggage 

Check 

400 AISLE 

429 

406 407 

404 405 

N9 

N8 

N7 

N6 

N5 

N4 

N3 

N2 

N1 

N10 

N11 

N12 

N13 

N14 

N15 

N16 

N17 

N18 

N 

Charles 

River 

413 

O9 O10 

O8 O11 

O7 O12 

O6 O13 

O5 O14 

04 O15 

O3 O16 

O2 O17 

O1 O18 

O 

536 537 

534 535 

532 533 

530 531 

528 529 

Hall G 

522 523 

520 521 

500 AISLE 

517 

515 

513 

506 507 

504 505 

502 503 

500 501 

WOMEN MEN 

Lobby G 

P 7 P 8 

P 6 P 9 

P 5 P 10 

P 4 P 11 

P 3 

P 12 

P 2 P 13 

P 1 P 14 

632 633 

622 623 

620 621 

616 

612 

606 

604 

UP TO REGISTRATION 

AND MEETING ROOMS 

634 635 

628 629 

600 AISLE 

602 603 

600 601 

Lobby G 

Message 

Center 

P Q 

605 

730 

702 

700 

728 

704 

732 

720 

Q9 

Q8 

Q7 

Q6 

Q5 

Q4 

Q3 

Q2 

Q1 

Q10 

Q11 

Q12 

Q13 

Q14 

Q15 

Q16 

Q17 

Q18 

723 

721 

707 

705 

701 

737 

735 

733 

729 

Thorlabs, 

Inc. 

700 AISLE 

R9 R10 

R8 R11 

R7 R12 

R6 R13 

R5 R14 

R4 R15 

R3 R16 

R2 R17 

R1 R18 

834 

822 

820 

806 

804 

836 

712 

R 

832 833 

830 831 

828 829 

800 AISLE 

817 

800 801 

835 

821 

813 

S 6 S 7 

S 5 S 8 

S 4 S 9 

S 3 S 10 

S 2 

S 1 S 12 

S 

S11 

ENTRANCE ENTRANCE 

BOX OFFICE G 

932 

922 923 

920 921 

916 917 

914 

912 

902 

928 

900 AISLE 

929 

907 

903 

900 901 

935 

931 

913 

T9 T10 

T8 T11 

T7 T12 

T6 

T13 

T5 T14 

T4 T15 

T3 T16 

T2 T17 

T1 T18 

T 

1028 

U 9 U 

U 8 U 

U 7 U 

U 6 U 

U 5 U 

U 4 

U 

U 3 U 

U 2 U 

U 1 U 

1012 1013 

1003 

1001 

U 

1030 1031 

1022 1023 

1020 1021 

1016 1017 

1014 1015 

1004 1005 

1000 

1000 AISLE 

Neu 

I 

W 

Lo

935 

931 

929 

23 

21 

17 

13 

07 

3 

1 

T9 T10 

T8 T11 

T7 T12 

T6 

T13 

T5 T14 

T4 T15 

T3 T16 

T2 T17 

T1 T18 

CE 

T 

U 9 U 10 

U 8 U 11 

U 7 U 12 

U 6 U 13 

U 5 U 14 

U 4 

U 15 

U 3 U 16 

U 2 U 17 

U 1 U 18 

U 

1030 1031 

1028 

1022 1023 

1020 1021 

1016 1017 

1014 1015 1114 

1003 

1001 1100 

V 9 V 10 

V 8 V 11 

Lobby F 

X9 X10 

W7 

W6 

W5 

W4 

W3 

W2 

W1 

W8 

V 7 V 12 

X8 X11 

V 13 

X7 X12 

V 6 

W9 

X6 X13 

V 5 

V 14 

W10 

X14 

V 4 V 15 

X5 

W11 

X4 

V 3 

V 16 X15 

W12 

V 2 V 17 

X3 X16 

W13 

V 1 V 18 

X2 X17 

W14 

X1 X18 

V 

Hall F 

WOMEN 

W 

1012 1013 1112 1113 1212 1213 

1000 

1000 AISLE 

1004 1005 

Neuralynx, 

Inc. 

1137 

1135 

1120 1121 

1100 AISLE 

1129 

1117 

1115 

1105 

1103 

1101 

Abstract Locators 

Concession Areas 

Publishers Row 

1232 1233 

1228 

1220 1221 

AISLE 

1200 

1200 

MEN 

Key 

X 

1231 1330 

1229 1328 

PerkinElmer 

Inc. 

Kopf 

Instruments, 

Inc. 

Elsevier 

ABSTRACT 

LOCATOR 

1300 AISLE 

Express Badge, 

Program, and 

Exhibit Guide 

Pick-up 

Institutions 

Nonprofits 

Y 9 Y 10 

Y 8 Y 11 

Y 7 Y 12 

Y 6 Y 13 

Y 5 Y 14 

Y 4 Y 15 

Y 3 Y 16 

Y 2 Y 17 

Y 1 Y 18 

Y 

1400 AISLE 

ENTRANCE 

Z8 

Z7 

Z6 Z9 

Z5 Z10 

Z4 Z11 

Z3 

Z12 

Z2 Z13 

Z1 Z14 

1435 

Z 

1536 

1534 

1431 1530 

1415 1514 

1413 1512 

A A9 AA10 

A A8 AA11 

A A7 AA12 

A A6 AA13 

A A5 AA14 

A A4 AA15 

A A3 AA16 

A A2 

AA17 

A A1 AA18 

AA 

1433 1532 1533 1632 

1417 1516 

1630 

1529 1628 

1523 1622 

1520 1521 1620 

1500 AISLE 

Sustaining Associate Members 

1535 

B B9 BB10 

B B8 BB11 

B B7 BB12 

B B6 BB13 

B B5 BB14 

B B4 BB15 

B B3 BB16 

B B2 BB17 

B B1 BB18 

BB 

1636 1637 

1634 1635 

Hall E 

1517 1616 1617 

1513 

1730 

1629 1728 

C C7 C C8 

C C6 C C9 

C C5 CC10 

C C4 CC11 

C C3 CC12 

C C2 CC13 

C C1 CC14 

CC 

ENTRANCE ENTRANCE ENTRANCE 

Shuttle 

Information 

1600 AISLE 

1732 

1621 1720 

1612 1613 1712 

STAR 

BUCKS 

1700 AISLE 

1723 1822 

1721 1820 

A TM 

Eppendorf 

North 

America 

1729 

Lobby E 

Shuttle Office 

DD7 DD8 

DD6 

DD9 

DD5 DD10 

DD4 DD11 

DD3 DD12 

DD2 DD13 

DD1 DD14 

DD 

1800 AISLE 

WOMEN MEN 

1835 

1831 

1829 

BOX OFFICE E 

EE9 EE10 

EE8 EE11 

EE7 EE12 

EE6 

EE13 

EE5 

EE14 

EE4 EE15 

EE3 EE16 

EE2 EE17 

EE1 EE18 

EE 

1936 

1934 

1833 1932 

Bio - Rad 

Laboratories 

1821 

Nikon 

Instruments, 

Inc. 

1812 

1917 

1913 

FF10 FF11 

FF9 

FF12 

FF8 

FF13 

FF7 

FF14 

FF6 

FF15 

FF5 

FF16 

FF4 FF17 

FF3 

FF18 

FF2 FF19 

FF1 FF20 

1915 

FF 

1935 2034 

1928 1929 

1900 AISLE 

1923 2022 

1921 2020 

GG8 GG9 

GG7 GG10 

GG6 GG11 

GG5 GG12 

GG4 GG13 

GG3 GG14 

GG2 GG15 

GG1 GG16 

GG 

2033 

2031 2130 

2013 

HH10 

HH9 

HH8 

HH7 

HH6 

HH5 

HH4 

HH3 

HH2 

HH1 

HH11 

HH12 

HH13 

HH14 

HH15 

HH16 

HH17 

HH18 

HH19 

HH20 

HH 

2036 2137 2236 

2012 

2000 AISLE 

2035 

AISLE 

2100 

Millipore 

Corporation 

2129 

Society 

for 

Neuroscience 

(SfN) 

II10 II11 

I I9 

II12 

I I8 

II13 

I I7 

II14 

I I6 II15 

I I5 II16 

I I4 II17 

I I3 II18 

I I2 II19 

I I1 II20 

II 

2200 AISLE 

2231 

JJ8 

JJ9 

JJ7 JJ10 

JJ6 JJ11 

JJ5 JJ12 

JJ4 JJ13 

JJ3 

JJ14 

JJ2 JJ15 

JJ1 JJ16 

JJ 

K K9 KK10 

K K8 

KK11 

KK12 

K K7 

KK13 

K K6 

KK14 

K K5 

KK15 

K K4 

KK16 

K K3 

K K2 KK17 

K K1 KK18 

KK 

Hall D 

LL6 

LL5 

LL8 

LL4 

LL9 

LL3 LL10 

LL2 LL11 

LL1 LL12 

LL 

2217 2316 2317 2416 2417 2516 

2213 

SfN 


Booth 

Olympus 

America, Inc. 

2314 

2312 

2422 

2221 2320 2321 2420 

2300 AISLE 

2313 

Exhibit 

Management 

2400 AISLE 

2421 

2532 

2412 2413 2512 

Lobby D 

M M7 M M8 

M M6 M M9 

M M5 

MM10 

M M4 

MM11 

M M3 MM12 

M M2 MM13 

M M1 MM14 

MM 

2537 2636 

2535 

2632 

NN7 NN8 

NN6 NN9 

NN5 NN10 

NN4 NN11 

NN3 NN12 

NN2 NN13 

NN1 NN14 

NN 

2429 2528 2529 2628 2629 2728 

Newport 

Corporation 

Exhibitor 

Registration 

2500 AISLE 

2521 2620 

2515 2614 

2600 AISLE 

2635 

2623 

2621 

2617 

2615 

2513 2612 2613 

Exhibitor 

Lounge 

2736 

2633 2732 

2720 

M

AISLE 

LL8 

LL9 

LL10 

LL11 

L12 

M M7 M M8 

M M6 M M9 

M M5 

MM10 

M M4 

MM11 

M M3 MM12 

M M2 MM13 

M M1 MM14 

MM 

2537 2636 

2535 

2615 

2513 2612 2613 

2623 

2621 

2617 

NN7 NN8 

NN6 NN9 

NN5 NN10 

NN4 NN11 

NN3 NN12 

NN2 NN13 

NN1 NN14 

NN 

OO9 OO10 

OO8 OO11 

OO7 OO12 

OO6 OO13 

OO5 OO14 

OO4 OO15 

OO3 OO16 

OO2 OO17 

OO1 

OO18 

OO 

2733 2832 

2830 

2529 2628 2629 2728 2729 2828 

2521 2620 

2515 2614 

2632 

2600 

AISLE 

2635 

2633 2732 

2720 

Express 

Badge 

Pick-up 

2736 

2700 AISLE 

2712 

2721 

2735 2834 

Hamamatsu 

Corporation 

Carl Zeiss 

Microimaging, 

Inc. 

PP 

ENTRANCE 

B A Y S I D E 

P P9 PP10 

P P8 

PP11 

P P7 PP12 

P P6 PP13 

P P5 PP14 

P P4 PP15 

P P3 PP16 

P P2 

PP17 

P P1 PP18 

QQ10 QQ11 

QQ9 QQ12 

QQ8 QQ13 

QQ7 QQ14 

QQ6 QQ15 

QQ5 

QQ16 

QQ4 QQ17 

QQ3 QQ18 

QQ2 QQ19 

QQ1 QQ20 

2800 AISLE 

RR10 RR11 

RR9 RR12 

RR8 RR13 

RR7 RR14 

RR6 RR15 

RR5 

RR16 

RR4 RR17 

FRE IGHT 

E LE VATORS 

TL 

DOWN 

TO PARK ING 

RO LL UP 

DOOR 

S E R V I C E C E N T E R 

SS10 SS11 

S S9 SS12 

S S8 SS13 

S S7 SS14 

S S6 

SS15 

SS16 

S S5 

S S4 SS17 

TT10 TT11 

TT9 TT12 

TT8 TT13 

TT7 TT14 

TT6 

TT15 

TT16 

TT5 

TT4 TT17 

U U4 U U5 

U U3 U U6 

U U2 U U7 

U U1 U U8 

UU 

N ETWORK 

S UPP ORT S HOW 

O FFICE C 

VV10 VV11 

V V9 VV12 

V V8 VV13 

V V7 VV14 

V V6 VV15 

V V5 VV16 

V V4 VV17 

RR3 RR18 

S S3 SS18 TT3 TT18 

V V3 VV18 WW3 WW18 XX3 XX18 

A AA3 A AA 20 B BB3 B BB 20 

CCC3 

CCC20 

RR2 RR19 

S S2 SS19 TT2 TT19 

12 

V V2 VV19 WW2 WW19 XX2 XX19 

11 

A AA2 A AA 21 B BB2 B BB 21 CCC2 CCC21 

10 

RR1 RR20 S S1 SS20 TT1 TT20 V V1 VV20 WW1 WW20 XX1 XX20 


6 

3312 3313 3412 

5 

3712 3713 3812 3813 

4 

3411 

WOMEN TL TL MEN 

S TAR 

B UCKS 

WW10 WW11 

WW9 WW12 

WW8 WW13 

WW7 WW14 

WW6 WW15 

WW5 WW16 

WW4 WW17 

MSI 

E LV T O PARKING 

MEN 

WOMEN 

TL 

RO LL UP 

DOOR 

WS 

TELE COM 

E LV 

BAYSIDE 

LOBBY 

TL TL 

QQ RR SS TT V V WW XX AA 

A BB 

B CCC 

Montreal Neurological Institute 

F 

2831 2930 

2825 2924 

2815 

2811 2910 

2809 

2807 

2926 

2916 

2912 

2904 

2900 AISLE 

2933 

2931 

2929 3028 3029 

2925 

Lecia 

Microsystems 

2907 

2801 2900 2901 3000 

3000 AISLE 

3027 

3019 3118 

3017 3116 

3003 3102 

3001 3100 

3133 

3131 

Hall C 

TL 

RESTAURANTS 

RESERVATIONS 

ENT RAN 

CE 

ENT 

RAN 

CE 

ENT 

RAN 

CE 

ENT 

Lobby C 

XX10 XX11 

XX9 XX12 

XX8 XX13 

XX7 XX14 

XX6 XX15 

XX5 XX16 

XX4 XX17 

3025 3124 3125 3224 3225 3324 3325 3424 3425 3524 

3013 

3007 

3130 

3100 AISLE 

3005 3104 3105 

3228 

TILL 

Photonics 

GmbH 

3117 

3101 3200 

3200 AISLE 

3332 

3231 3330 

3229 3328 3329 3428 

3217 3316 

First Aid Coat and Luggage Check 

3326 3327 3426 

3314 

3308 

3300 AISLE 

3331 

3319 

3432 

3317 3416 

3414 

Sigma 

Life 

Science 

3400 AISLE 

3419 3518 

Y Y5 Y Y6 ZZ5 ZZ6 

Y Y4 

Y Y7 

ZZ4 ZZ7 



Y Y1 YY10 ZZ1 ZZ10 

3516 

YY 

3533 

ZZ 

3304 3305 3405 3504 Molecular 

Devices, 

3203 3302 

3403 

Inc. 

3201 3300 3301 3400 3401 3500 3501 

3531 3630 3631 3730 

ABSTRACT 

LOCATOR 

A AA 11 A AA 12 B BB 11 B BB 12 

CCC11 CCC12 

DDD5 DDD6 

A AA 10 A AA 13 B BB 10 B BB 13 CCC10 CCC13 

DDD4 DDD7 

A AA9 A AA 14 

B BB 14 

B BB9 

CCC9 CCC14 DDD3 DDD8 

A AA8 A AA 15 

B BB8 B BB 15 CCC8 CCC15 

DDD2 DDD9 

A AA7 A AA 16 

B BB 16 

B BB7 

CCC7 CCC16 DDD1 DDD10 


DDD 

A AA5 A AA 18 

B BB 18 

B BB5 

CCC5 CCC18 

A AA4 A AA 19 B BB4 B BB 19 

CCC4 CCC19 

EEE5 EEE6 

EEE4 EEE7 

EEE3 EEE8 

EEE2 EEE9 

EEE1 EEE10 

EEE 

Hall B2 

FFF11 FFF12 

FFF10 FFF13 

FFF14 

FFF9 

FFF8 FFF15 

FFF7 FFF16 

FFF6 FFF17 

FFF5 FFF18 

FFF4 FFF19 

FFF3 FFF20 

FFF2 FFF21 

FFF1 FFF22 

3529 

3728 3729 3828 

3928 3929 

3427 3627 3726 

3826 

3926 3927 

4126 

3500 AISLE 

3525 3624 

3618 3619 

3732 

3625 3724 

3517 3616 3617 3716 

3600 AISLE 

3714 3715 3814 3815 

3708 3709 3808 3809 

3706 3707 3806 3807 

3704 

3601 3700 

Abstract Locators 

Concession Areas 

Publishers Row 

3700 AISLE 

NDP 3932 

4 032 4033 4132 

3731 3830 3831 3930 3931 4030 4031 4130 

3725 3824 

3719 

3717 3816 

3800 AISLE 

3819 3918 3919 4018 4019 

3817 3916 3917 4016 4017 4116 

3804 3805 3904 3905 4004 

3703 3802 3803 3902 3903 4002 

3701 3800 3801 3900 3901 4000 

Key 

ATM 

E LV 

G 

G 

G 

G 

G 

G 

G 

G 

G 

G 

G 

3825 3924 3925 4024 4025 4124 4 

Institutions 

Nonprofits 

3900 AISLE 

4000 AISLE 

Sustaining Associate Members 

4114 

NIH 

National 

Institute 

on Drug 

Abuse 

(NIDA) 

4001 

F 

4 

4 

4112 4 

4110 4 

4100 AISLE 

N 

o 

4 

L

ATM 

E LV 

WS 

ENT 

RAN 

CE 

RO LL UP 

DOOR 

HHH12 HHH13 

FFF11 FFF12 GGG11 


FFF9 

FFF14 GGG9 









GGG12 HHH11 HHH14 


GGG14 HHH9 

HHH16 






GGG20 

HHH3 HHH22 



TL 

Lobby B 

MEN 

WOMEN 

WOMEN 

E LV T O PARKING 

TL TL 

S HO W 

O FFICE B 

P PP 34 

III 25 III 26 

III 24 III 27 

III 23 III 28 

III 22 III 29 

III 21 I II 30 


JJJ 25 JJJ 26 

JJJ 27 

JJJ 24 

JJJ 28 

JJJ 23 

JJJ 29 

JJJ 22 

JJJ 21 JJJ30 

JJJ31 

JJJ 20 

K KK 35 K KK 36 

K KK 34 

K KK 37 

K KK 33 K KK 38 

K KK 32 

K KK 39 

LLL35 LLL36 

LLL34 LLL37 

LLL33 LLL38 

LLL32 LLL39 

MMM37 MMM38 

MMM36 

MMM39 

MMM40 

MMM35 

MMM41 

MMM34 

MMM42 

MMM33 

MMM43 

MMM32 

NNN25 NNN26 

NNN24 NNN27 

NNN23 NNN28 

NNN22 NNN29 

NNN21 NNN30 

NNN20 NNN31 

OOO37 OOO38 

OOO36 

OOO39 

OOO35 OOO40 

OOO41 

OOO34 

OOO33 OOO42 

OOO32 OOO43 

P PP 33 

P PP 32 

P PP 31 

P PP 30 

P PP 29 

III JJJ K KK 31 

K KK 40 

K KK 30 K KK 41 

LLL31 LLL40 

LLL30 LLL41 

MMM44 

MMM31 

MMM45 

MMM30 

OOO31 

OOO30 

OOO44 

OOO45 

P PP 28 

P PP 27 

P PP 26 

9 

K KK 29 K KK 42 

K KK 28 K KK 43 

K KK 27 K KK 44 

K KK 26 K KK 45 

LLL29 LLL42 

LLL28 LLL43 

LLL27 LLL44 

LLL26 LLL45 

MMM46 

MMM29 

MMM47 

MMM28 

MMM48 

MMM27 

MMM26 

MMM49 

8 

OOO29 OOO46 

OOO28 OOO47 

OOO27 

OOO48 

OOO49 

OOO26 

P PP 25 

P PP 24 

P PP 23 

P PP 22 

7 

F G 

HHH 

KK 

K LLL 

MMM 

NNN 

3 4132 

1 4130 

HHH25 

4233 HHH26 

HHH27 

4231 

HHH28 

HHH29 

4126 

4227 

HHH30 

HHH31 

5 4124 4125 4224 4225 

HHH32 

9 

7 4116 

4114 

4112 4113 

4110 4111 4210 

NIH 

ational 

stitute 

Drug 

buse 

IDA) 

01 

4100 AISLE 

National 

Science 

Foundation 

(NSF) 

4129 

4115 

NIH 

National 

Institute 

of Mental 

Health 

(NIMH) 

4101 

4200 AISLE 



III 17 III 34 

III 16 III 35 

III 15 III 36 

III 14 III 37 

III 13 III 38 

III 12 III 39 

III 11 III 40 

JJJ 19 JJJ32 

JJJ 18 JJJ33 

JJJ 17 JJJ 34 

JJJ 16 JJJ 35 

JJJ 15 JJJ 36 

JJJ 14 JJJ 37 

JJJ 13 JJJ 38 

JJJ 12 JJJ 39 

JJJ 11 JJJ 40 

K KK 25 K KK 46 

K KK 24 K KK 47 

K KK 23 K KK 48 

K KK 22 K KK 49 

K KK 21 K KK 50 

K KK 20 K KK 51 

K KK 19 K KK 52 

K KK 18 K KK 53 

K KK 17 K KK 54 

MMM25 MMM50 

LLL25 LLL46 

NNN19 NNN32 

LLL24 LLL47 MMM24 MMM51 

NNN18 NNN33 

LLL23 LLL48 MMM23 MMM52 NNN17 NNN34 

LLL22 LLL49 MMM22 MMM53 

NNN35 

NNN16 

ENT 

RAN 

CE 

Lobby A 

B OX 

O FFICE A 

EXIT 

OOO25 

OOO24 

OOO23 

OOO22 

OO 

O 

OOO50 

OOO51 

OOO52 

OOO53 

LLL21 LLL50 MMM21 MMM54 NNN15 NNN36 OOO21 OOO54 


LLL19 LLL52 MMM19 MMM56 NNN13 NNN38 OOO19 

OOO56 

LLL18 

MMM18 MMM57 

NNN12 NNN39 

OOO57 

LLL53 

OOO18 


Hall B1 

TL TL 

MEN WOMEN MEN 

DOWN 

TO PARK ING 

MEN 

WOMEN 

ABSTRACT 

LOCATOR 

HHH33 III 10 III 41 JJJ 10 JJJ 41 K KK 16 K KK 55 LLL16 LLL55 MMM16 MMM59 NNN10 NNN41 OOO16 OOO59 

HHH34 I II 9 III 42 JJJ 9 JJJ 42 K KK 15 K KK 56 LLL15 LLL56 MMM15 MMM60 NNN9 NNN42 

OOO15 OOO60 

HHH35 I II 8 III 43 JJJ 8 JJJ 43 K KK 14 K KK 57 LLL14 LLL57 

MMM14 MMM61 NNN8 NNN43 

OOO14 OOO61 

HHH36 I II 7 III 44 JJJ 7 JJJ 44 K KK 13 K KK 58 LLL13 LLL58 MMM13 MMM62 NNN7 NNN44 

OOO13 OOO62 

4215 

HHH37 

K KK 12 K KK 59 LLL12 LLL59 MMM12 MMM63 

OOO12 OOO63 

P PP 13 

4209 

HHH38 

HHH39 

HHH40 

HHH41 

HHH42 

3 

K KK 11 K KK 60 

K KK 10 K KK 61 

K KK9 K KK 62 

K KK8 K KK 63 

K KK7 K KK 64 

LLL11 LLL60 

LLL10 LLL61 

LLL9 LLL62 

LLL8 LLL63 

LLL7 LLL64 

MMM11 MMM64 

MMM10 MMM65 

MMM9 MMM66 

MMM8 

MMM67 

MMM7 MMM68 

2 

OOO11 

OOO10 

OOO9 

OOO8 

OOO7 

OOO64 

OOO65 

OOO66 

OOO67 

OOO68 

P PP 12 

P PP 11 

P PP 10 

P PP9 

P PP8 

1 

P PP7 

4207 

HHH43 

HHH44 

I II 6 III 45 

I II 5 III 46 

JJJ 6 

JJJ 5 

JJJ 45 

JJJ 46 

K KK6 K KK 65 

K KK 5 K KK 66 

LLL6 LLL65 

LLL5 LLL66 

MMM6 MMM69 

M MM 5 MMM70 

NNN6 NNN45 

NNN5 NNN46 

OOO6 

OOO5 

OOO69 

OOO70 

P PP6 

P PP 5 

4205 HHH45 

HHH46 

I II 4 III 47 

I II 3 III 48 

JJJ 4 JJJ 47 

JJJ 3 JJJ 48 

K KK4 

K KK3 

K KK 67 

K KK 68 

LLL4 LLL67 

LLL3 LLL68 

MMM4 

MMM71 

MMM3 MMM72 

NNN4 

NNN3 

NNN47 

NNN48 

OOO4 

OOO3 

OOO71 

OOO72 

P PP4 

P PP3 

HHH47 I II 2 I II 49 JJJ 2 JJJ49 K KK2 K KK 69 LLL2 LLL69 MMM2 MMM73 NNN2 NNN49 OOO2 OOO73 

P PP2 

HHH48 

4201 

HHH 

I II 1 I II 50 

III 

JJJ 1 JJJ50 

JJJ 

K KK1 K KK 70 

KKK 

LLL1 LLL70 

LLL 

MMM1 MMM74 

MMM 

NNN1 NNN50 

NNN 

OOO1 OOO74 

000 

P PP1 

PPP 

ABSTRACT 

LOCATOR 

SfN 


Booth 

Lobby A 

Message 

Center 

P PP 21 

P PP 20 

P PP 19 

P PP 18 

P PP 17 

P PP 16 

P PP 15 

P PP 14 

WS 

S TAR 

B UCKS 

RO LL UP 

DOOR 

TL 

S HO W 

O FFICE A 

Lecture Overflow Hall 

Express 

Badge 

Pick-up 

E XIT 

Hall A 

Program and 

Exhibit Guide 

Pick-up 

E XIT 

TIDES 

E XIT 

S ER VICE 

ELEVA TORS

Hotel Floor Plans 

Manchester Grand Hyatt Floor Plan

Marriott Hotel & Marina Floor Plan 

South Tower North Tower 

Level 1 

Lobby Level 

Second Floor

Marriott Hotel & Marina Floor Plan (continued) 

South Tower 

Lobby Level 

Bayside 

Seaview 

1st Floor 

Laguna 

Leucadia 

Oceanside 

Pacific 

Point Loma 

Santa Rosa 

Solana 

Business Center 

3rd Floor 

Balboa 

Board Room 

Cardiff 

Carlsbad 

Del Mar 

Encinitas 

Green Room 

Marina Ballroom D-G 

Mission Hills 

4th Floor 

Coronado Room/Terrace 

Irvine 

Los Angeles 

Newport Beach 

Rancho Las Palmas 

Torrance 

Warner Center 

North Tower 

Lobby Level 

Columbia Rooms 1–3 

Manchester Rooms 1–2 

Torrey Rooms 1–3 

San Diego Ballrooms A–C 

Marriott Hall 

Anaheim 

Atlanta 

Chicago 

Marriott Hall 1–6 

New York 

Orlando 

San Francisco 

Level 3 

Level 4

Hilton San Diego Bayfront 

Colbalt Level � 

Indigo Level �

Hilton San Diego Bayfront (continued) 

Sapphire Level �

See you in 

Washington, DC! 

november 12–16, 2011

november 15, 2010 

San Diego 

SoCiety for neuroSCienCe 

Final program 

Monday 

California 

Scientific Sessions listings 

Sessions 310 – 516

nanosymposium - Society for Neuroscience

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