2022 Annual Report

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Translating impact from lab to clinic VAN ANDEL INSTITUTE–STAND UP TO CANCER EPIGENETICS DREAM TEAM The Institute is home to the VAI–SU2C Epigenetics Dream Team, a multi-institutional, collaborative effort that brings together several of the world’s most respected research and clinical organizations to translate scientific discoveries into improved patient care. The goal is simple — get new, more effective cancer therapies to patients faster. INTERNATIONAL LINKED CLINICAL TRIALS PROGRAM The Cure Parkinson’s–Van Andel Institute International Linked Clinical Trials Program identifies potential new therapies for Parkinson’s from medications developed to treat other diseases that also show potential for impeding Parkinson’s disease progression. By doing so, iLCT aims to significantly cut the amount of time it takes for a potential treatment to move from the lab to clinical trials and, ultimately, to people with Parkinson’s. Combining two cancer medications may increase survival in relapsed myelodysplastic syndrome A pair of cancer medications that act as a one-two punch against malignant cells demonstrated increased survival in patients with relapsed/refractory myelodysplastic syndrome (MDS) by an average of 10 months compared to historical controls, according to results from a phase 1/2 clinical trial published in Clinical Cancer Research. The trial was supported by the Van Andel Institute–Stand Up To Cancer Epigenetics Dream Team, a multi-institutional effort to move potential combination cancer treatments into clinical trials. Around the Institute Promising top-line results demonstrated for diabetes drug in Parkinson’s Top-line results from a clinical trial of the diabetes medication liraglutide in Parkinson’s disease indicate that liraglutide improves aspects of daily living and non-motor symptoms in people with Parkinson’s. The trial was conducted by researchers from Cedars Sinai Hospital, Los Angeles, and co-funded by Van Andel Institute and Cure Parkinson’s through the International Linked Clinical Trials Program. In addition to improving overall average survival from five to 15 months, the trial findings suggest the effectiveness of combining medications that target the immunological and epigenetic drivers of cancers. 1 Funding Acknowledgement 1 Research funding for this work was provided by Van Andel Institute through the Van Andel Institute–Stand Up To Cancer Epigenetics Dream Team. Stand Up To Cancer is a division of the Entertainment Industry Foundation. The clinicialtrials.gov identifier for this trial is: NCT02935361. 16
RESEARCH Research by the numbers VAI–SU2C Epigenetics Dream Team 4 Clinical trials ongoing, enrolling patients 3 Clinical trials in correlative analyses, enrollment closed 7 Clinical trials closed International Linked Clinical Trials 17 Clinical trials ongoing 15 Clinical trials completed over the life of the program * Numbers current as of December <strong>2022</strong> 15 17
Page 1 and 2: 2022 Annual Report
Page 3 and 4: Table of Contents 2 A letter from D
Page 5 and 6: “From all of us at Van Andel Inst
Page 8 and 9: Department of Neurodegenerative Sci
Page 10 and 11: Department of Epigenetics Scientist
Page 12 and 13: Department of Cell Biology Our heal
Page 14 and 15: Department of Structural Biology Sc
Page 16 and 17: Department of Metabolism & Nutritio
Page 20 and 21: Core Technologies & Services Van An
Page 22 and 23: Van Andel Institute Principal Inves
Page 30 and 31: A modern approach to graduate educa
Page 32 and 33: A modern approach to graduate educa
Page 34: Van Andel Institute for Education W
Page 37 and 38: K-12 EDUCATION 35
Page 39 and 40: K-12 EDUCATION 37
Page 42 and 43: Carol Van Andel Angel of Excellence
Page 44 and 45: Design & Discovery Merging the insp
Page 46 and 47: Around the World Hosted by VAI’s
Page 48 and 49: Couture for a Cure Michigan’s pre
Page 50 and 51: Hope on the Hill & The Chocolate Fa
Page 52 and 53: Signature special event sponsors We
Page 54 and 55: A decade of support: Inside Jeffery
Page 56 and 57: Positivity & perseverance: Richard
Page 58 and 59: From Purple Community to JBoard Amb
Page 60 and 61: Running for family & research Nearl
Page 62 and 63: Philanthropy Circle of Hope Anonymo
Page 64 and 65: Van Andel Institute Board Members V
Page 66 and 67: Van Andel Institute Board of Govern
Page 68:
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2022 Annual Report

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