YSM Issue 96.2
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Physiology / Astronomy<br />
NEWS<br />
A NEW APPROACH<br />
TO AN OLD FOE<br />
INNOVATION IN AORTIC<br />
ANEUR<strong>YSM</strong> SURGERY<br />
BY JOHNNY YUE<br />
TAKING A PEEK<br />
AT PANDORA’S<br />
CLUSTER<br />
LOOKING UP AT SPACE WITH<br />
THE JAMES WEBB SPACE<br />
TELESCOPE<br />
BY IGNACIO RUIZ-SANCHEZ<br />
IMAGE COURTESY OF NAIEM NASSIRI<br />
IMAGE COURTESY OF PIXABAY<br />
Thoracoabdominal aneurysms (TAAAs) occur when the<br />
aorta—the artery carrying blood from the heart to the rest of<br />
the body—balloons and weakens, which can lead to internal<br />
bleeding. Up until the past few years, TAAA surgery required<br />
highly invasive procedures with high chances of debilitating side<br />
effects, including paraplegia, or lower body paralysis.<br />
Endovascular Debranched Aortic Repair (EDAR), a new<br />
surgical technique performed at Yale, was first invented by<br />
Patrick Kelly of Sanford Health in South Dakota. Vascular<br />
surgeon Naiem Nassiri learned about the technology under<br />
Kelly’s guidance. “I built six prototypes on my breakfast table, and<br />
some took up to six hours to build,” Nassiri said. Together with<br />
Prashanth Vallabhajosyula, director of Yale’s Aortic Institute, the<br />
medical duo has implemented EDAR to treat the weakened aorta<br />
in a minimally-invasive manner. “TAAA surgery used to involve<br />
patients getting their entire chest, abdomen, and diaphragm split<br />
open, and the procedures were attached to high morbidity and<br />
mortality,” Vallabhajosyula said.<br />
But EDAR simply involves a stent that is inserted into the<br />
body through two small penetrations made in the groin using<br />
a needle. The stent, compressed in a tube, is delivered through<br />
blood vessels to the aorta. “We’ve done about sixteen cases and<br />
haven’t encountered any paraplegia cases (patient paralysis),”<br />
Vallabhajosyula said.<br />
EDAR shows tremendous promise to treat TAAAs. “What is<br />
wonderful about this platform is that at any time, you can decide to<br />
stop the operation and bring the patient back at a later date,” Nassiri<br />
said. “This minimizes the harm for the patient.” With the surgeons’<br />
expertise, TAAA patients now have new hope for better outcomes. ■<br />
The black background of outer space is studded with<br />
white bursts of light—some are sharp lines, while others<br />
are surrounded by a white hazy glow. In the foreground<br />
sits a star from our own galaxy, shining among a giant group<br />
of galaxies located four billion light years away from Earth:<br />
Pandora’s Cluster. After the launch of NASA’s James Webb<br />
Space Telescope, we’ve been fortunate to witness images from<br />
the distant corners of our universe, but these are the first,<br />
detailed images of Pandora itself.<br />
Scientists have been monitoring this galaxy cluster for over<br />
a decade, utilizing the most advanced technology available,<br />
mainly the Hubble Space Telescope, to get a glimpse of<br />
Pandora. However, none have achieved as much as the Webb<br />
Telescope to capture stellar pictures of the cluster, unveiling<br />
never-before-seen details. The new images were a tireless effort<br />
by the Ultradeep NIRSpec and NIRCam ObserVations before<br />
the Epoch of Reionization (UNCOVER) program, whose team<br />
of astronomers included several Yale scientists. The team<br />
captured thirty hours of data using Webb’s Near-Infrared<br />
Camera (NIRcam), with wavelengths capable of detecting the<br />
earliest stars in the process of formation and nearby galaxy<br />
populations. What’s even more exciting is that the telescope<br />
captured Pandora as a megacluster, meaning the combined<br />
mass of the four galaxies creates a powerful gravitational lens<br />
to expose other very large distant galaxies in the early Universe.<br />
While strikingly beautiful, these images are not just potential<br />
dorm-room posters or lock screens—this achievement could<br />
ultimately help us discover other hidden galaxies, further<br />
unraveling the mysteries of our Universe. ■<br />
www.yalescientific.org<br />
May 2023 Yale Scientific Magazine 7