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YSM Issue 96.2

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Physiology / Astronomy<br />

NEWS<br />

A NEW APPROACH<br />

TO AN OLD FOE<br />

INNOVATION IN AORTIC<br />

ANEUR<strong>YSM</strong> SURGERY<br />

BY JOHNNY YUE<br />

TAKING A PEEK<br />

AT PANDORA’S<br />

CLUSTER<br />

LOOKING UP AT SPACE WITH<br />

THE JAMES WEBB SPACE<br />

TELESCOPE<br />

BY IGNACIO RUIZ-SANCHEZ<br />

IMAGE COURTESY OF NAIEM NASSIRI<br />

IMAGE COURTESY OF PIXABAY<br />

Thoracoabdominal aneurysms (TAAAs) occur when the<br />

aorta—the artery carrying blood from the heart to the rest of<br />

the body—balloons and weakens, which can lead to internal<br />

bleeding. Up until the past few years, TAAA surgery required<br />

highly invasive procedures with high chances of debilitating side<br />

effects, including paraplegia, or lower body paralysis.<br />

Endovascular Debranched Aortic Repair (EDAR), a new<br />

surgical technique performed at Yale, was first invented by<br />

Patrick Kelly of Sanford Health in South Dakota. Vascular<br />

surgeon Naiem Nassiri learned about the technology under<br />

Kelly’s guidance. “I built six prototypes on my breakfast table, and<br />

some took up to six hours to build,” Nassiri said. Together with<br />

Prashanth Vallabhajosyula, director of Yale’s Aortic Institute, the<br />

medical duo has implemented EDAR to treat the weakened aorta<br />

in a minimally-invasive manner. “TAAA surgery used to involve<br />

patients getting their entire chest, abdomen, and diaphragm split<br />

open, and the procedures were attached to high morbidity and<br />

mortality,” Vallabhajosyula said.<br />

But EDAR simply involves a stent that is inserted into the<br />

body through two small penetrations made in the groin using<br />

a needle. The stent, compressed in a tube, is delivered through<br />

blood vessels to the aorta. “We’ve done about sixteen cases and<br />

haven’t encountered any paraplegia cases (patient paralysis),”<br />

Vallabhajosyula said.<br />

EDAR shows tremendous promise to treat TAAAs. “What is<br />

wonderful about this platform is that at any time, you can decide to<br />

stop the operation and bring the patient back at a later date,” Nassiri<br />

said. “This minimizes the harm for the patient.” With the surgeons’<br />

expertise, TAAA patients now have new hope for better outcomes. ■<br />

The black background of outer space is studded with<br />

white bursts of light—some are sharp lines, while others<br />

are surrounded by a white hazy glow. In the foreground<br />

sits a star from our own galaxy, shining among a giant group<br />

of galaxies located four billion light years away from Earth:<br />

Pandora’s Cluster. After the launch of NASA’s James Webb<br />

Space Telescope, we’ve been fortunate to witness images from<br />

the distant corners of our universe, but these are the first,<br />

detailed images of Pandora itself.<br />

Scientists have been monitoring this galaxy cluster for over<br />

a decade, utilizing the most advanced technology available,<br />

mainly the Hubble Space Telescope, to get a glimpse of<br />

Pandora. However, none have achieved as much as the Webb<br />

Telescope to capture stellar pictures of the cluster, unveiling<br />

never-before-seen details. The new images were a tireless effort<br />

by the Ultradeep NIRSpec and NIRCam ObserVations before<br />

the Epoch of Reionization (UNCOVER) program, whose team<br />

of astronomers included several Yale scientists. The team<br />

captured thirty hours of data using Webb’s Near-Infrared<br />

Camera (NIRcam), with wavelengths capable of detecting the<br />

earliest stars in the process of formation and nearby galaxy<br />

populations. What’s even more exciting is that the telescope<br />

captured Pandora as a megacluster, meaning the combined<br />

mass of the four galaxies creates a powerful gravitational lens<br />

to expose other very large distant galaxies in the early Universe.<br />

While strikingly beautiful, these images are not just potential<br />

dorm-room posters or lock screens—this achievement could<br />

ultimately help us discover other hidden galaxies, further<br />

unraveling the mysteries of our Universe. ■<br />

www.yalescientific.org<br />

May 2023 Yale Scientific Magazine 7

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